Page last updated: 2024-09-04

beta-lactams and glycidyl nitrate

beta-lactams has been researched along with glycidyl nitrate in 110 studies

Compound Research Comparison

Studies
(beta-lactams)
Trials
(beta-lactams)
Recent Studies (post-2010)
(beta-lactams)
Studies
(glycidyl nitrate)
Trials
(glycidyl nitrate)
Recent Studies (post-2010) (glycidyl nitrate)
7,5791793,3957,74983,379

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-199016 (14.55)18.7374
1990's2 (1.82)18.2507
2000's22 (20.00)29.6817
2010's47 (42.73)24.3611
2020's23 (20.91)2.80

Authors

AuthorsStudies
Kitano, K; Tomasz, A1
Brown, CA; Perkins, HR1
Aoki, H; Hosoda, J; Imanaka, H; Kunugita, K1
Hammes, WP; Seidel, H1
Beauchamp, D; Bergeron, MG; Brochu, A; Clairoux, N; Gourde, P; Malouin, F; Parr, TR; Picard, M; Rousseau, N1
Tsuji, A1
Tomasz, A; Weisholtz, S1
Brocks, V; Christenson, JG; Schaefer, F; Talbot, MK1
Sazykin, IuO1
Collatz, E; Gutmann, L; Williamson, R1
Dougherty, TJ; Garcia-Bustos, JF1
Tipper, DJ1
Edwards, JR; Park, JT; Wise, EM1
Frère, JM; Ghuysen, JM; Leyh-Bouille, M; Perkins, HR1
Rao, VS; Vasudevan, TK1
Charlier, P; Coyette, J; Dideberg, O; Duez, C; Dusart, J; Frère, JM; Ghuysen, JM; Joris, B; Leyh-Bouille, M; Nguyen-Distèche, M1
Blundell, JK; Perkins, HR1
Mirelman, D; Nuchamowitz, Y; Rubinstein, E1
Gutmann, L; van Heijenoort, J1
Diehl, A; Ehlert, K; Hakenbeck, R; Labischinski, H; Reichmann, P; Weber, B1
Levy, SB; McMurry, LM; Wong, RS1
Koch, AL1
Aritaka, N; Cui, L; Hanaki, H; Hiramatsu, K1
Hara, Y; Hu, ZQ; Okubo, S; Shimamura, T; Zhao, WH1
Arthur, M; Blanot, D; Cremniter, J; Fourgeaud, M; Frehel, C; Gutmann, L; Legrand, R; Mainardi, JL; Morel, V; Van Heijenoort, J1
de Lencastre, H; Filipe, SR; Gardete, S; Ludovice, AM; Sobral, RG; Tomasz, A1
Josephine, HR; Kelly, JA; Kuzin, AP; Nagarajan, R; Pratt, RF; Silvaggi, NR1
Arthur, M; Brouard, JP; Dubost, L; Fourgeaud, M; Gutmann, L; Hugonnet, JE; Mainardi, JL; Ouazzani, J; Rice, LB1
Arthur, M; Cremniter, J; Dubost, L; Gutmann, L; Hugonnet, JE; Josseaume, N; Mainardi, JL; Marie, A; Quincampoix, JC; Rice, LB1
Courvalin, P; Périchon, B1
Charlier, P; Davies, C; Josephine, HR; Nicholas, RA; Pratt, RF1
Kuroda, M; Nagasaki, S; Ohta, T1
Ayala, JA; D'Ari, R; Joseleau-Petit, D; Liébart, JC1
Ayala, J; Daniel, RA; Gil, JA; Letek, M; Mateos, LM; Ordóñez, E; Valbuena, N1
Josephine, HR; Kumar, I; Pratt, RF1
Ayala, JA; Charlier, P; Kerff, F; Sauvage, E; Terrak, M1
Arthur, M; Blanot, D; Dubost, L; Fourgeaud, M; Gutmann, L; Lavollay, M; Mainardi, JL; Marie, A; Veziris, N1
Pratt, RF1
Charlier, P; Davies, C; Heilemann, J; Josephine, HR; Powell, AJ; Pratt, RF; Sauvage, E1
Arthur, M; Dubost, L; Fourgeaud, M; Gutmann, L; Lavollay, M; Mainardi, JL; Marie, A; Riegel, P1
Arthur, M; Blanot, D; Cremniter, J; Dubost, L; Hugonnet, JE; Josseaume, N; Mainardi, JL; Marie, A; Patin, D; Rice, LB; Sacco, E1
Avison, MB; Ayala, JA; Baker, JA; Bennett, PM; Niumsup, P; Tayler, AE; Walsh, TR; Westphal, K; Wiedemann, B; Zhang, L1
Hanaki, H; Ikeda, S; Ikeda-Dantsuji, Y; Iwatsuki, M; Matsui, H; Nakae, T; Omura, S; Shiomi, K; Sunakawa, K; Yanagisawa, C1
Brown, S; Campbell, J; Kim, Y; Mylonakis, E; Santa Maria, JP; Singh, AK; Swoboda, JG; Walker, S; Wilkinson, BJ1
Branny, P; Hesek, D; Lee, M; Leyva, E; Maestro, B; Mobashery, S; Novaková, L; Sanz, JM1
Adediran, SA; Kumar, I; Nagarajan, R; Pratt, RF; Sauvage, E1
Bertsche, U; Fedtke, I; Göhring, N; Jorge, AM; Peschel, A; Pinho, MG; Xia, G1
Cheng, H; Jarantow, LW; Lee, SH; Meredith, TC; Roemer, T; Sillaots, S; Thompson, J; Wang, H1
Mark, BL; Oliver, A; Vocadlo, DJ1
Inokoshi, J; Koyama, N; Tomoda, H1
Brock, M; Fazius, F; Zaehle, C1
Burrows, LL; Cavallari, JF; Lamers, RP; Matos, AL; Scheurwater, EM1
Bacik, JP; Gloster, TM; Mark, BL; Perley-Robertson, GE; Stubbs, KA; Vocadlo, DJ; Whitworth, GE1
Arthur, M; Cordillot, M; Dubée, V; Dubost, L; Hugonnet, JE; Mainardi, JL; Marie, A; Triboulet, S1
Abrahams, KA; Breukink, E; Philippe, J; Roper, DI; Signor, L; Vernet, T; Zapun, A1
Berisio, R; Calvanese, L; D'Auria, G; Falcigno, L; Maglione, C; Marasco, D; Ruggiero, A; Squeglia, F1
Figueiredo, TA; Ludovice, AM; Sobral, RG1
Denapaite, D; Hakenbeck, R; Peters, K; Schweizer, I; Stahlmann, C1
Bæk, KT; Frees, D; Gründling, A; Mogensen, RG; Paulander, W; Petersen, A; Thøgersen, L1
Fisher, JF; Mobashery, S1
Gao, H; Jin, M; Jin, S; Ju, L; Mao, Y; Sun, Y; Yin, J1
Aertsen, A; Ayala, JA; Briers, Y; Cambré, A; Cenens, W; Lavigne, R; Loessner, MJ; Michiels, CW; Noben, JP; Sauer, U; Vivijs, B; Zimmermann, M1
Boneca, IG; Burke, TP; Loukitcheva, A; Portnoy, DA; Wheeler, R; Zemansky, J1
Aldridge, C; Gray, J; Halbedel, S; Möller, L; Rismondo, J; Vollmer, W1
Bernhardt, TG; Cho, H; Uehara, T1
Aguilera, C; Ayala, JA; Cabot, G; Moya, B; Oliver, A; Ropy, A; Sánchez-Diener, I1
Becker, T; Bui, NK; Gray, J; Hakenbeck, R; Maurer, P; Rieger, M; Todorova, K; Vollmer, W1
Arthur, M; Bougault, CM; Hugonnet, JE; Laguri, C; Simorre, JP; Triboulet, S1
Crick, DC; Mahapatra, S; Pavelka, MS1
Foster, SJ; Rosado, H; Taylor, PW; Turner, RD1
Aguilera Rossi, CG; Ayala Serrano, JA; Gómez-Puertas, P1
Azadi, P; Chen, J; Edgar, RJ; Forsberg, LS; Jaehrig, B; Kant, S; Korotkov, KV; Korotkova, N; Pancholi, V; Rechkina, E; Rush, JS; Sokurenko, EV; Tchesnokova, V; Zhu, H1
Chen, W; Davies, C; Zhang, YM1
Guignard, B; Majcherczyk, PA; Monachon, C; Moreillon, P; Vouillamoz, J1
Schneider, G; Schnell, R; Steiner, EM1
Clarke, AJ1
Kahne, D; Qiao, Y; Schaefer, K; Srisuknimit, V; Walker, S1
Alexander, JAN; Basuino, L; Chambers, HF; Chatterjee, SS; Jousselin, A; Pinho, MG; Strynadka, NCJ1
Arthur, M; Braud, E; Ehrt, S; Ethève-Quelquejeu, M; Fonvielle, M; Hugonnet, JE; Iannazzo, L; Mengin-Lecreulx, D; Ngadjeua, F; Patin, D; Saidjalolov, S; Schnappinger, D1
Gasper, J; Held, K; Manoil, C; Morgan, S; Siehnel, R; Singh, P1
Errington, J; Kawai, Y; Mickiewicz, K1
Becker, A; Gray, J; Heimerl, T; Kaever, V; Krol, E; Schäper, S; Skotnicka, D; Søgaard-Andersen, L; Vollmer, W; Yau, HCL1
Cai, J; Qiu, J; Xu, C; Yin, J; Yu, Z; Zhang, T1
Arthur, M; Edoo, Z; Hugonnet, JE; Martorana, AM; Pazos, M; Peters, K; Polissi, A; VanNieuwenhze, MS; Vollmer, W1
Errington, J; Kawai, Y; Mercier, R; Mickiewicz, K; Serafini, A; Sório de Carvalho, LP1
Barceló, IM; Jordana-Lluch, E; Juan, C; Oliver, A; Sánchez-Diener, I; Torrens, G; Zamorano, L1
Auer, GK; Jensen, GJ; Lin, TY; Oliver, PM; Rajendram, M; Weibel, DB; Yao, Q1
Apostolos, AJ; Pidgeon, SE; Pires, MM1
Li, D; Li, H; Liu, Z; Ma, X; Tang, H; Tang, Y; Yu, W1
Beatty, KE1
Alharbi, M; Alharbi, O; Biboy, J; Derrick, JP; Gallagher, LA; Grunert, T; Ingmer, H; Liu, H; Mayer, K; McBain, AJ; Mikkelsen, K; Nøhr-Meldgaard, K; O'Gara, JP; Sirisarn, W; Vestergaard, M; Vollmer, W; Xia, G1
Arthur, M; Braud, E; Edoo, Z; Etheve-Quelquejeu, M; Fonvielle, M; Iannazzo, L; Riomet, M; Rusconi, F; Saidjalolov, S; Sallustrau, A; Taran, F1
Qiao, Y; Tan, CT; Wang, Y; Xu, X1
Atkinson, CE; Caveney, NA; Strynadka, NCJ; Workman, SD; Yan, R; Yu, Z1
Batchelder, HR; Galanis, C; Kumar, G; Lamichhane, G; Townsend, CA1
Chen, L; Composto, K; Kreiswirth, BN; Kurepina, N; Nuermberger, EL; Rifat, D1
Ahmad, N; Ahmed, S; Bishai, WR; Chauhan, V; Dugad, S; Kachhap, S; Kumar, P; Lamichhane, G; Sharma, K; Zaidi, R1
Arthur, M; Atze, H; Gutierrez, A; Hugonnet, JE; Liang, Y; Rusconi, F1
Anes, E; Catalão, MJ; Gomes, JP; Macedo, R; Miragaia, M; Nunes, A; Olivença, F; Pires, D; Silveiro, C1
Booth, S; Chen, X; Foster, SJ; Hobbs, JK; Lafage, L; Lewis, RJ; Pazos, M; Rao, VA; Vollmer, W; Wacnik, K1
Choi, U; Lee, CR; Lee, HB; Lee, JW; Park, SH; Ryu, SH1
Hu, X; Liang, Y; Lou, J; Luo, Y; Meng, Q; Yin, J; Yu, Z; Zhu, T; Zhu, Y1
A Faria, N; de Lencastre, H; Gonçalves Sobral, R; Miragaia, M; Mwangi, M; Portela, R; Tomasz, A1
Nie, Y; Qin, X; Wu, XL; Zhang, K1
Couté, Y; da Silva Barreira, D; Guzzo, J; Lapaquette, P; Novion Ducassou, J; Rieu, A1
Martinez-Bond, EA; Soriano, BM; Williams, AH1
Arthur, M; Hugonnet, JE; Kennedy, SP; Sezonov, G; Voedts, H1
Helmann, JD; Patel, Y; Rhee, KY; Soni, V1
Kwan, JMC; Liang, Y; Qiao, Y; Wang, Y; Zhao, Y1
Helmann, JD; Patel, Y; Willdigg, JR1

Reviews

12 review(s) available for beta-lactams and glycidyl nitrate

ArticleYear
Mode of action of beta-lactam antibiotics.
    Pharmacology & therapeutics, 1985, Volume: 27, Issue:1

    Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactams; Carrier Proteins; Cell Wall; Escherichia coli; Gram-Positive Bacteria; Hexosyltransferases; Kinetics; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin Resistance; Penicillin-Binding Proteins; Penicillins; Peptidoglycan; Peptidyl Transferases; Structure-Activity Relationship

1985
Conformation and activity of beta-lactam antibiotics.
    CRC critical reviews in biochemistry, 1983, Volume: 14, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; beta-Lactams; Binding Sites; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Molecular Conformation; Peptidoglycan; Structure-Activity Relationship; Thermodynamics

1983
Penicillin binding proteins, beta-lactams, and lactamases: offensives, attacks, and defensive countermeasures.
    Critical reviews in microbiology, 2000, Volume: 26, Issue:4

    Topics: Bacteria; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Carrier Proteins; Hexosyltransferases; Hydrolysis; Models, Molecular; Muramoylpentapeptide Carboxypeptidase; Penicillin Resistance; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Structure-Activity Relationship

2000
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.
    FEMS microbiology reviews, 2008, Volume: 32, Issue:2

    Topics: Bacteria; Bacterial Proteins; beta-Lactamases; beta-Lactams; Glycosyltransferases; Multienzyme Complexes; Penicillin-Binding Proteins; Peptide Hydrolases; Peptidoglycan; Peptidoglycan Glycosyltransferase; Peptidyl Transferases; Protein Structure, Tertiary

2008
Substrate specificity of bacterial DD-peptidases (penicillin-binding proteins).
    Cellular and molecular life sciences : CMLS, 2008, Volume: 65, Issue:14

    Topics: Bacteria; beta-Lactams; Carbohydrate Sequence; Models, Molecular; Molecular Weight; Penicillin-Binding Proteins; Peptidoglycan; Protease Inhibitors; Serine-Type D-Ala-D-Ala Carboxypeptidase; Substrate Specificity

2008
Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway.
    Future microbiology, 2011, Volume: 6, Issue:12

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Enterobacteriaceae; Gene Expression; Humans; Mutation; Peptidoglycan; Pseudomonas aeruginosa

2011
Anti-infectious agents against MRSA.
    Molecules (Basel, Switzerland), 2012, Dec-24, Volume: 18, Issue:1

    Topics: Acetylcysteine; Alkyl and Aryl Transferases; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Diterpenes; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mycotoxins; Organothiophosphorus Compounds; Peptidoglycan; Spiro Compounds; Teichoic Acids; Vancomycin; Virulence Factors; Xanthophylls

2012
The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.
    Bioorganic chemistry, 2014, Volume: 56

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Enterobacteriaceae; Microbial Sensitivity Tests; Peptidoglycan; Pseudomonas aeruginosa

2014
Genetics of Peptidoglycan Biosynthesis.
    Microbiology spectrum, 2014, Volume: 2, Issue:4

    Topics: Anti-Bacterial Agents; beta-Lactams; Biosynthetic Pathways; Mycobacterium; Peptidoglycan

2014
[Progress in regulatory mechanism for inducing β-lactamase in Gram-negative bacteria].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2018, Aug-25, Volume: 34, Issue:8

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Gram-Negative Bacteria; Peptidoglycan; Signal Transduction

2018
Fluorescent probes for investigating peptidoglycan biosynthesis in mycobacteria.
    Current opinion in chemical biology, 2020, Volume: 57

    Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Biosynthetic Pathways; Fluorescent Dyes; Humans; Models, Molecular; Mycobacterium tuberculosis; Optical Imaging; Peptides; Peptidoglycan; Peptidyl Transferases; Tuberculosis; Vancomycin

2020
The mechanistic landscape of Lytic transglycosylase as targets for antibacterial therapy.
    Current opinion in structural biology, 2022, Volume: 77

    Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactams; Cell Wall; Glycosyltransferases; Peptidoglycan

2022

Other Studies

98 other study(ies) available for beta-lactams and glycidyl nitrate

ArticleYear
Triggering of autolytic cell wall degradation in Escherichia coli by beta-lactam antibiotics.
    Antimicrobial agents and chemotherapy, 1979, Volume: 16, Issue:6

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Escherichia coli; Hydrolases; Peptidoglycan; RNA, Bacterial; Spheroplasts; Time Factors

1979
In vitro synthesis of peptidoglycan by beta-lactam-sensitive and -resistant strains of Neisseria gonorrhoeae: effects of beta-lactam and other antibiotics.
    Antimicrobial agents and chemotherapy, 1979, Volume: 16, Issue:1

    Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Neisseria gonorrhoeae; Peptidoglycan

1979
Screening of new and novel beta-lactam antibiotics.
    The Japanese journal of antibiotics, 1977, Volume: 30 Suppl

    Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Escherichia coli; Mutation; Peptidoglycan

1977
The LD-carboxypeptidase activity in Gaffkya homari. The target of the action of certain beta-lactam antibiotics on the formation of wall-bound peptidoglycan.
    European journal of biochemistry, 1978, Nov-15, Volume: 91, Issue:2

    Topics: Anti-Bacterial Agents; beta-Lactams; Carboxypeptidases; Cell Wall; Cephalosporins; Kinetics; Muramic Acids; Oligopeptides; Penicillin G; Peptidoglycan; Streptococcaceae; Uridine Diphosphate N-Acetylmuramic Acid

1978
Molecular basis of the non-beta-lactamase-mediated resistance to beta-lactam antibiotics in strains of Haemophilus influenzae isolated in Canada.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:7

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Autoradiography; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactamases; beta-Lactams; Canada; Carrier Proteins; Cells, Cultured; Child, Preschool; Electrophoresis, Polyacrylamide Gel; Haemophilus influenzae; Hexosyltransferases; Humans; Microbial Sensitivity Tests; Middle Aged; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases

1992
[Mechanism of susceptibility and resistance of bacteria to beta-lactam antibiotics].
    Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:10

    Topics: Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carrier Proteins; Cell Membrane Permeability; Cell Wall; Drug Resistance, Microbial; Hexosyltransferases; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Pseudomonas aeruginosa

1991
Response of Legionella pneumophila to beta-lactam antibiotics.
    Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:5

    Topics: Anti-Bacterial Agents; beta-Lactams; Cell Wall; Chromatography, Thin Layer; Glucosamine; Hydrogen-Ion Concentration; Hydrolysis; Legionella; Microbial Sensitivity Tests; Penicillins; Peptidoglycan; RNA, Bacterial

1985
Reactivation of peptidoglycan synthesis in ether-permeabilized Escherichia coli after inhibition by beta-lactam antibiotics.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:12

    Topics: Anti-Bacterial Agents; Bacillus cereus; Bacterial Proteins; beta-Lactams; Biotransformation; Carrier Proteins; Cross-Linking Reagents; Escherichia coli; Ethers; Hexosyltransferases; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Uridine Diphosphate N-Acetylmuramic Acid

1989
[Penicillin and the biochemistry of the microbial cell].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1989, Volume: 34, Issue:7

    Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamases; beta-Lactams; Biological Evolution; Carrier Proteins; Cell Membrane; Chemical Phenomena; Chemistry; Hexosyltransferases; Hydrolases; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Penicillins; Peptidoglycan; Peptidyl Transferases

1989
[Mechanisms of action of beta-lactam antibiotics and mechanisms of non-enzymatic resistance].
    Presse medicale (Paris, France : 1983), 1986, Dec-20, Volume: 15, Issue:46

    Topics: Anti-Bacterial Agents; beta-Lactams; Cell Membrane; Cell Membrane Permeability; Drug Resistance, Microbial; Penicillin Resistance; Peptidoglycan

1986
Alterations in peptidoglycan of Neisseria gonorrhoeae induced by sub-MICs of beta-lactam antibiotics.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:2

    Topics: Acyltransferases; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Carrier Proteins; Cell Wall; Chromatography, High Pressure Liquid; Disaccharides; Hexosyltransferases; Multienzyme Complexes; Muramoylpentapeptide Carboxypeptidase; Neisseria gonorrhoeae; Oligopeptides; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases

1987
In vivo studies on the uptake and binding of beta-lactam antibiotics in relation to inhibition of wall synthesis and cell death.
    Annals of the New York Academy of Sciences, 1974, May-10, Volume: 235, Issue:0

    Topics: Acyltransferases; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Binding Sites; Carbon Radioisotopes; Cell Wall; Cephalosporins; Enterococcus faecalis; Glycerol; Microbial Sensitivity Tests; Penicillin G; Penicillins; Peptidoglycan; Staphylococcus; Streptococcus; Tritium

1974
Interaction between beta-lactam antibiotics and exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61.
    European journal of biochemistry, 1974, Dec-16, Volume: 50, Issue:1

    Topics: Acyltransferases; Anti-Bacterial Agents; beta-Lactams; Carbenicillin; Carboxypeptidases; Cephalosporins; Kinetics; Penicillin G; Penicillin V; Peptidoglycan; Protein Binding; Streptomyces

1974
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics.
    Scandinavian journal of infectious diseases. Supplementum, 1984, Volume: 42

    Topics: Amino Acyl-tRNA Synthetases; Anti-Bacterial Agents; Bacteria; beta-Lactams; Cell Wall; Chymotrypsin; Dipeptidases; Models, Biological; Peptidoglycan; Peptidyl Transferases; Structure-Activity Relationship

1984
Effects of beta-lactam antibiotics on peptidoglycan synthesis in growing Neisseria gonorrhoeae, including changes in the degree of O-acetylation.
    Journal of bacteriology, 1981, Volume: 147, Issue:2

    Topics: Acetylation; beta-Lactams; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Muramidase; Neisseria gonorrhoeae; Penicillin G; Peptidoglycan; Thienamycins

1981
Insensitivity of peptidoglycan biosynthetic reactions to beta-lactam antibiotics in a clinical isolate of Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 1981, Volume: 19, Issue:5

    Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cell Wall; Drug Resistance, Microbial; Humans; Peptidoglycan; Protein Binding; Pseudomonas aeruginosa; Pseudomonas Infections; Species Specificity

1981
Correlation between the structure of the bacterial peptidoglycan monomer unit, the specificity of transpeptidation, and susceptibility to beta-lactams.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, May-09, Volume: 97, Issue:10

    Topics: Anti-Bacterial Agents; Bacteria; beta-Lactam Resistance; beta-Lactams; Carbohydrate Sequence; Molecular Sequence Data; Peptidoglycan

2000
The fib locus in Streptococcus pneumoniae is required for peptidoglycan crosslinking and PBP-mediated beta-lactam resistance.
    FEMS microbiology letters, 2000, Jul-01, Volume: 188, Issue:1

    Topics: Amino Acid Sequence; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Carrier Proteins; Chromatography, High Pressure Liquid; Hexosyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Muramoylpentapeptide Carboxypeptidase; Mutagenesis, Insertional; Operon; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Sequence Analysis, DNA; Streptococcus pneumoniae

2000
'Intergenic' blr gene in Escherichia coli encodes a 41-residue membrane protein affecting intrinsic susceptibility to certain inhibitors of peptidoglycan synthesis.
    Molecular microbiology, 2000, Volume: 37, Issue:2

    Topics: Alkaline Phosphatase; Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; beta-Lactams; Blotting, Northern; DNA Transposable Elements; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Insertional; Peptidoglycan

2000
Combination effect of vancomycin and beta-lactams against a Staphylococcus aureus strain, Mu3, with heterogeneous resistance to vancomycin.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:4

    Topics: Anti-Bacterial Agents; beta-Lactams; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Therapy, Combination; Microbial Sensitivity Tests; Peptidoglycan; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2001
Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:6

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; beta-Lactams; Catechin; Cell Wall; Drug Synergism; Methicillin Resistance; Microbial Sensitivity Tests; Peptidoglycan; Staphylococcus aureus

2001
Balance between two transpeptidation mechanisms determines the expression of beta-lactam resistance in Enterococcus faecium.
    The Journal of biological chemistry, 2002, Sep-27, Volume: 277, Issue:39

    Topics: Alanine; Ampicillin; Anti-Bacterial Agents; beta-Lactams; Cell Division; Cell Membrane; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cytoplasm; Dipeptides; Drug Resistance; Enterococcus faecium; Escherichia coli; Lysine; Mass Spectrometry; Microscopy, Electron; Models, Biological; Muramoylpentapeptide Carboxypeptidase; Peptidoglycan; Peptidyl Transferases; Protein Structure, Tertiary; Time Factors

2002
Role of murE in the Expression of beta-lactam antibiotic resistance in Staphylococcus aureus.
    Journal of bacteriology, 2004, Volume: 186, Issue:6

    Topics: Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Cell Wall; Culture Media; Gene Expression Regulation, Bacterial; Isopropyl Thiogalactoside; Methicillin Resistance; Microbial Sensitivity Tests; Mutation; Peptide Synthases; Peptidoglycan; Staphylococcus aureus; Transcription, Genetic

2004
Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin".
    Journal of molecular biology, 2005, Jan-21, Volume: 345, Issue:3

    Topics: beta-Lactams; Crystallography, X-Ray; Models, Molecular; Penicillins; Peptidoglycan; Protein Conformation; Serine-Type D-Ala-D-Ala Carboxypeptidase

2005
A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway.
    The Journal of biological chemistry, 2005, Nov-18, Volume: 280, Issue:46

    Topics: Alanine; Amino Acid Sequence; Ampicillin; Animals; Anti-Bacterial Agents; beta-Lactams; Brain; Catalysis; Cell Wall; Chromatography; Chromatography, Ion Exchange; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Enterococcus faecium; Escherichia coli; Mass Spectrometry; Models, Biological; Models, Chemical; Models, Genetic; Molecular Sequence Data; Peptides; Peptidoglycan; Peptidyl Transferases; Protein Binding; Substrate Specificity

2005
Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium.
    The Journal of biological chemistry, 2006, Oct-27, Volume: 281, Issue:43

    Topics: Alanine; Amino Acid Substitution; Anti-Bacterial Agents; beta-Lactams; Cross-Linking Reagents; Cytoplasm; Drug Resistance, Bacterial; Enterococcus faecium; Glycopeptides; Hydrolysis; Microbial Sensitivity Tests; Models, Biological; Muramoylpentapeptide Carboxypeptidase; Peptide Fragments; Peptidoglycan; Substrate Specificity

2006
Synergism between beta-lactams and glycopeptides against VanA-type methicillin-resistant Staphylococcus aureus and heterologous expression of the vanA operon.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:11

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Carbon-Oxygen Ligases; Diffusion; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Glycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Operon; Oxacillin; Penicillins; Peptide Hydrolases; Peptidoglycan; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus; Vancomycin Resistance

2006
Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?
    Biochemistry, 2006, Dec-26, Volume: 45, Issue:51

    Topics: Actinomycetales; beta-Lactams; Binding Sites; Cephalosporins; Escherichia coli; Molecular Mimicry; Neisseria gonorrhoeae; Penicillin-Binding Proteins; Penicillins; Peptidoglycan; Serine-Type D-Ala-D-Ala Carboxypeptidase; Streptococcus pneumoniae

2006
Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 59, Issue:3

    Topics: beta-Lactamases; beta-Lactams; Biological Transport; Cell Wall; Farnesol; Methicillin Resistance; Mevalonic Acid; Microbial Sensitivity Tests; Penicillin-Binding Proteins; Peptidoglycan; Polyisoprenyl Phosphates; Staphylococcus aureus; Xanthophylls

2007
Unstable Escherichia coli L forms revisited: growth requires peptidoglycan synthesis.
    Journal of bacteriology, 2007, Volume: 189, Issue:18

    Topics: Anti-Bacterial Agents; beta-Lactams; Cefsulodin; Cell Division; Cell Wall; Culture Media; Escherichia coli; L Forms; Mutation; Peptidoglycan; Piperacillin

2007
Characterization of HMW-PBPs from the rod-shaped actinomycete Corynebacterium glutamicum: peptidoglycan synthesis in cells lacking actin-like cytoskeletal structures.
    Molecular microbiology, 2007, Volume: 66, Issue:3

    Topics: Actins; beta-Lactams; Corynebacterium glutamicum; Cytoskeleton; Microbial Sensitivity Tests; Microscopy, Fluorescence; Molecular Weight; Mutation; Penicillin-Binding Proteins; Peptidoglycan; Protein Binding

2007
Reactions of peptidoglycan-mimetic beta-lactams with penicillin-binding proteins in vivo and in membranes.
    ACS chemical biology, 2007, Sep-21, Volume: 2, Issue:9

    Topics: beta-Lactams; Biomimetics; Escherichia coli; Penicillin-Binding Proteins; Peptides; Peptidoglycan; Streptococcus pneumoniae

2007
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation.
    Journal of bacteriology, 2008, Volume: 190, Issue:12

    Topics: Anti-Bacterial Agents; beta-Lactams; Models, Biological; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Spectrometry, Mass, Electrospray Ionization

2008
Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.
    Journal of molecular biology, 2008, Aug-29, Volume: 381, Issue:2

    Topics: Actinomycetales; Arginine; Bacterial Proteins; beta-Lactams; Binding Sites; Crystallography, X-Ray; Escherichia coli; Models, Biological; Models, Molecular; Molecular Structure; Penicillin-Binding Proteins; Peptidoglycan; Protein Structure, Secondary; Serine-Type D-Ala-D-Ala Carboxypeptidase; Substrate Specificity

2008
The beta-lactam-sensitive D,D-carboxypeptidase activity of Pbp4 controls the L,D and D,D transpeptidation pathways in Corynebacterium jeikeium.
    Molecular microbiology, 2009, Volume: 74, Issue:3

    Topics: Amino Acid Sequence; Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Carboxypeptidases; Catalytic Domain; Cell Wall; Corynebacterium; Escherichia coli; Molecular Sequence Data; Mycobacterium tuberculosis; Oligopeptides; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Proteins; Substrate Specificity; Vancomycin Resistance

2009
Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium.
    Molecular microbiology, 2010, Volume: 75, Issue:4

    Topics: Anti-Bacterial Agents; Base Sequence; beta-Lactams; Cell Wall; Drug Resistance, Bacterial; Enterococcus faecium; Glycopeptides; Molecular Sequence Data; Peptidoglycan; Proteins; Substrate Specificity; Uridine Diphosphate N-Acetylmuramic Acid

2010
Induction of beta-lactamase production in Aeromonas hydrophila is responsive to beta-lactam-mediated changes in peptidoglycan composition.
    Microbiology (Reading, England), 2010, Volume: 156, Issue:Pt 8

    Topics: Aeromonas hydrophila; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Mutagenesis, Insertional; Peptidoglycan; Vancomycin

2010
Identification of the active component that induces vancomycin resistance in MRSA.
    The Journal of antibiotics, 2010, Volume: 63, Issue:9

    Topics: Anti-Bacterial Agents; beta-Lactams; Cell Wall; Chromatography, Liquid; Gene Expression Regulation, Bacterial; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methicillin-Resistant Staphylococcus aureus; Peptidoglycan; Sequence Analysis, Protein; Transcriptional Activation; Vancomycin Resistance

2010
Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus.
    ACS chemical biology, 2011, Jan-21, Volume: 6, Issue:1

    Topics: Anti-Bacterial Agents; beta-Lactams; Cell Wall; Colocasia; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Teichoic Acids; Tunicamycin

2011
Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae.
    FEBS letters, 2011, Jan-21, Volume: 585, Issue:2

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Binding Sites; Cell Wall; Models, Molecular; Peptidoglycan; Protein Binding; Protein Interaction Domains and Motifs; Protein Serine-Threonine Kinases; Spectrum Analysis; Streptococcus pneumoniae

2011
Kinetics of reactions of the Actinomadura R39 DD-peptidase with specific substrates.
    Biochemistry, 2011, Jan-25, Volume: 50, Issue:3

    Topics: Actinomycetales; Acylation; Alanine; beta-Lactams; Kinetics; Models, Chemical; Molecular Mimicry; Peptidoglycan; Serine-Type D-Ala-D-Ala Carboxypeptidase; Substrate Specificity; Sulfhydryl Compounds

2011
New role of the disulfide stress effector YjbH in β-lactam susceptibility of Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:12

    Topics: Bacillus subtilis; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Disulfides; Humans; Penicillin-Binding Proteins; Peptidoglycan; Respiratory Burst; Sequence Deletion; Staphylococcus aureus; Thioredoxins

2011
Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics.
    Chemistry & biology, 2011, Nov-23, Volume: 18, Issue:11

    Topics: Anti-Bacterial Agents; beta-Lactams; DNA, Antisense; Drug Resistance, Bacterial; Methicillin-Resistant Staphylococcus aureus; Peptidoglycan

2011
Lysine biosynthesis in microbes: relevance as drug target and prospects for β-lactam antibiotics production.
    Applied microbiology and biotechnology, 2013, Volume: 97, Issue:9

    Topics: Aconitate Hydratase; Anti-Bacterial Agents; beta-Lactams; Diaminopimelic Acid; Hydro-Lyases; Industrial Microbiology; Lysine; Peptidoglycan

2013
Changes to its peptidoglycan-remodeling enzyme repertoire modulate β-lactam resistance in Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Glycosyltransferases; Microbial Sensitivity Tests; Penicillin-Binding Proteins; Peptidoglycan; Pseudomonas aeruginosa

2013
The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams.
    Chembiochem : a European journal of chemical biology, 2013, Oct-11, Volume: 14, Issue:15

    Topics: Anti-Bacterial Agents; beta-Lactams; Drug Discovery; Enzyme Inhibitors; Gram-Negative Bacteria; Hexosaminidases; Humans; Microbial Sensitivity Tests; Models, Molecular; Peptidoglycan; Protein Conformation

2013
In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12

    Topics: Antitubercular Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Cell Wall; Clavulanic Acid; Doripenem; Enzyme Assays; Ertapenem; Escherichia coli; Gene Expression; Imipenem; Kinetics; Meropenem; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Recombinant Proteins; Thienamycins

2013
In vitro reconstitution of peptidoglycan assembly from the Gram-positive pathogen Streptococcus pneumoniae.
    ACS chemical biology, 2013, Dec-20, Volume: 8, Issue:12

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactams; Cell Wall; Genetic Engineering; Glutamic Acid; Glutamine; Homologous Recombination; Penicillin-Binding Proteins; Peptidoglycan; Peptidoglycan Glycosyltransferase; Peptidyl Transferases; Streptococcus pneumoniae; Uridine Diphosphate N-Acetylmuramic Acid

2013
Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.
    Biopolymers, 2014, Volume: 101, Issue:7

    Topics: Bacterial Proteins; beta-Lactams; Calorimetry; Circular Dichroism; Magnetic Resonance Spectroscopy; Models, Molecular; Mycobacterium tuberculosis; Penicillin-Binding Proteins; Peptidoglycan; Protein Binding; Protein Structure, Tertiary; Protein Unfolding; Temperature

2014
Contribution of peptidoglycan amidation to beta-lactam and lysozyme resistance in different genetic lineages of Staphylococcus aureus.
    Microbial drug resistance (Larchmont, N.Y.), 2014, Volume: 20, Issue:3

    Topics: Adaptation, Physiological; Amides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Biological Transport; Cell Wall; Drug Resistance, Bacterial; Gene Expression; Metabolic Networks and Pathways; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Muramidase; Operon; Peptide Synthases; Peptidoglycan

2014
Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.
    Microbial drug resistance (Larchmont, N.Y.), 2014, Volume: 20, Issue:3

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Gene Expression; Green Fluorescent Proteins; Heat-Shock Proteins; Molecular Sequence Data; Mutation; Penicillin-Binding Proteins; Peptidoglycan; Periplasmic Proteins; Protein Interaction Domains and Motifs; Protein Stability; Proteolysis; Recombinant Fusion Proteins; Serine Endopeptidases; Streptococcus pneumoniae

2014
β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Cell Wall; Endopeptidase Clp; Gene Expression Regulation, Bacterial; Isoenzymes; Metabolic Networks and Pathways; Methicillin-Resistant Staphylococcus aureus; Mutation; N-Acetylmuramoyl-L-alanine Amidase; Penicillin-Binding Proteins; Peptidoglycan

2014
Distinct roles of major peptidoglycan recycling enzymes in β-Lactamase production in Shewanella oneidensis.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11

    Topics: Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; beta-N-Acetylhexosaminidases; DNA-Binding Proteins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Gene Knockout Techniques; Gram-Negative Bacterial Infections; Membrane Transport Proteins; Microbial Sensitivity Tests; Penicillin-Binding Proteins; Peptidoglycan; Promoter Regions, Genetic; Pseudomonas aeruginosa; Shewanella

2014
Metabolite profiling and peptidoglycan analysis of transient cell wall-deficient bacteria in a new Escherichia coli model system.
    Environmental microbiology, 2015, Volume: 17, Issue:5

    Topics: beta-Lactam Resistance; beta-Lactams; Cell Wall; Escherichia coli; Escherichia coli Proteins; Gene Library; Membrane Lipids; Models, Biological; Penicillin-Binding Proteins; Peptidoglycan; Serine-Type D-Ala-D-Ala Carboxypeptidase

2015
Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.
    Journal of bacteriology, 2014, Volume: 196, Issue:21

    Topics: Amidohydrolases; Animals; Anti-Bacterial Agents; beta-Lactams; Carboxypeptidases; Cell Wall; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Listeria monocytogenes; Listeriosis; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Muramidase; Mutagenesis, Insertional; Peptidoglycan; Virulence

2014
Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes.
    Molecular microbiology, 2015, Volume: 95, Issue:2

    Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; HeLa Cells; Humans; Listeria monocytogenes; Mice; Microbial Sensitivity Tests; Mutation; Penicillin-Binding Proteins; Peptidoglycan; Virulence

2015
Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery.
    Cell, 2014, Dec-04, Volume: 159, Issue:6

    Topics: Amdinocillin; Anti-Bacterial Agents; beta-Lactams; Cell Wall; Escherichia coli; Glycoside Hydrolases; Penicillin-Binding Proteins; Peptidoglycan

2014
Role of Pseudomonas aeruginosa low-molecular-mass penicillin-binding proteins in AmpC expression, β-lactam resistance, and peptidoglycan structure.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:7

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Boron Compounds; Carboxypeptidases; Cell Membrane; Gene Knockout Techniques; Microbial Sensitivity Tests; Mutation; Penicillin-Binding Proteins; Penicillins; Peptidoglycan; Pseudomonas aeruginosa

2015
Transfer of penicillin resistance from Streptococcus oralis to Streptococcus pneumoniae identifies murE as resistance determinant.
    Molecular microbiology, 2015, Volume: 97, Issue:5

    Topics: Amino Acid Sequence; Bacterial Proteins; beta-Lactams; Drug Resistance, Multiple, Bacterial; Penicillin Resistance; Penicillin-Binding Proteins; Peptide Synthases; Peptidoglycan; Peptidyl Transferases; Piperacillin; Streptococcus oralis; Streptococcus pneumoniae; Transformation, Genetic

2015
Acyl acceptor recognition by Enterococcus faecium L,D-transpeptidase Ldtfm.
    Molecular microbiology, 2015, Volume: 98, Issue:1

    Topics: Acylation; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Binding Sites; Catalytic Domain; Enterococcus faecium; Ertapenem; Models, Molecular; Molecular Docking Simulation; Mutagenesis, Site-Directed; Peptidoglycan; Peptidyl Transferases; Substrate Specificity

2015
Impact of the β-Lactam Resistance Modifier (-)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus.
    International journal of molecular sciences, 2015, Jul-23, Volume: 16, Issue:8

    Topics: beta-Lactams; Cardiolipins; Catechin; Cell Membrane; Lysine; Membrane Lipids; Methicillin-Resistant Staphylococcus aureus; Microscopy, Atomic Force; Peptidoglycan; Phenotype; Phosphatidylglycerols; Phospholipids

2015
In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa.
    BMC microbiology, 2016, 10-06, Volume: 16, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Carboxypeptidases; Cefoxitin; Cross Infection; DNA, Bacterial; Endopeptidases; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Penicillin-Binding Proteins; Peptidoglycan; Pseudomonas aeruginosa; Recombinant Proteins

2016
SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in
    Frontiers in cellular and infection microbiology, 2016, Volume: 6

    Topics: Anti-Bacterial Agents; Bacterial Adhesion; beta-Lactams; Carrier Proteins; Cell Wall; Drug Resistance, Bacterial; Gene Deletion; Glycosides; Heme; Heme-Binding Proteins; Hemeproteins; N-Acetylmuramoyl-L-alanine Amidase; Peptidoglycan; Protein Binding; Protein Multimerization; Streptococcus pyogenes

2016
Penicillin-Binding Protein 3 Is Essential for Growth of Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Penicillin-Binding Proteins; Peptidoglycan; Pseudomonas aeruginosa

2017
Muropeptide signature of inhibitors of protein synthesis correlates with β-lactam synergism against methicillin-resistant Staphylococcus aureus.
    International journal of antimicrobial agents, 2017, Volume: 49, Issue:1

    Topics: Anti-Bacterial Agents; beta-Lactams; Cell Wall; Chromatography, High Pressure Liquid; Drug Synergism; Mass Spectrometry; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Peptides; Peptidoglycan; Protein Synthesis Inhibitors

2017
Binding and processing of β-lactam antibiotics by the transpeptidase Ldt
    The FEBS journal, 2017, Volume: 284, Issue:5

    Topics: beta-Lactams; Carbapenems; Crystallography, X-Ray; Kinetics; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Protein Conformation; Tuberculosis

2017
Peptidoglycan: Another brick in the wall.
    Nature chemical biology, 2017, 06-20, Volume: 13, Issue:7

    Topics: beta-Lactams; Cell Wall; Peptidoglycan; Peptidyl Transferases; Uridine Diphosphate N-Acetylmuramic Acid

2017
Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections.
    Journal of the American Chemical Society, 2017, 07-26, Volume: 139, Issue:29

    Topics: Anti-Bacterial Agents; beta-Lactams; Cross-Linking Reagents; Methicillin-Resistant Staphylococcus aureus; Molecular Structure; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Staphylococcal Infections

2017
PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance.
    The Journal of antimicrobial chemotherapy, 2018, 05-01, Volume: 73, Issue:5

    Topics: beta-Lactam Resistance; beta-Lactams; Chromatography, Liquid; Gene Expression; Hydrolysis; Mutation, Missense; Penicillin-Binding Proteins; Peptidoglycan; Point Mutation; Serial Passage; Staphylococcus aureus

2018
Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Apr-17, Volume: 24, Issue:22

    Topics: beta-Lactams; Cell Wall; Enterococcus faecium; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Transaminases

2018
Determinants of Extreme β-Lactam Tolerance in the Burkholderia pseudomallei Complex.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:4

    Topics: beta-Lactams; Burkholderia pseudomallei; Meropenem; Peptidoglycan

2018
Lysozyme Counteracts β-Lactam Antibiotics by Promoting the Emergence of L-Form Bacteria.
    Cell, 2018, 02-22, Volume: 172, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Bacillus subtilis; Bacteriolysis; beta-Lactams; Cell Wall; Hydrolases; L Forms; Macrophages; Mice; Microbial Viability; Muramidase; Osmoregulation; Penicillin G; Penicillin-Binding Proteins; Peptidoglycan; Prophages; RAW 264.7 Cells

2018
Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales.
    PLoS genetics, 2018, Volume: 14, Issue:8

    Topics: Alphaproteobacteria; Bacterial Proteins; beta-Lactams; Carrier Proteins; Cell Wall; Cyclic GMP; Gene Expression Regulation, Bacterial; Membrane Proteins; Microscopy, Electron, Transmission; Peptidoglycan; Phosphoric Diester Hydrolases; Receptors, G-Protein-Coupled; Second Messenger Systems; Sinorhizobium meliloti

2018
Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 10-16, Volume: 115, Issue:42

    Topics: Aminoacyltransferases; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactams; Cell Wall; Copper; Enterococcus faecium; Escherichia coli; Microbial Sensitivity Tests; Penicillin-Binding Proteins; Peptidoglycan; Substrate Specificity; Trace Elements

2018
Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics.
    Nature microbiology, 2019, Volume: 4, Issue:10

    Topics: Bacillus subtilis; beta-Lactams; Carbon; Cell Wall; Electron Transport; Enterococcus faecium; Gluconeogenesis; L Forms; Muramidase; Mutation; Penicillin G; Peptidoglycan; Phosphoenolpyruvate Sugar Phosphotransferase System; Reactive Oxygen Species

2019
In Vivo Validation of Peptidoglycan Recycling as a Target to Disable AmpC-Mediated Resistance and Reduce Virulence Enhancing the Cell-Wall-Targeting Immunity.
    The Journal of infectious diseases, 2019, 10-22, Volume: 220, Issue:11

    Topics: Animals; Bacteremia; Bacterial Load; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Ceftazidime; Cell Wall; Disease Models, Animal; Female; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Peptidoglycan; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Tract Infections; Survival Analysis; Treatment Outcome; Virulence

2019
Bacterial Swarming Reduces Proteus mirabilis and Vibrio parahaemolyticus Cell Stiffness and Increases β-Lactam Susceptibility.
    mBio, 2019, 10-08, Volume: 10, Issue:5

    Topics: Anti-Bacterial Agents; beta-Lactams; Chemical Phenomena; Locomotion; Mechanical Phenomena; Microbial Viability; Microfluidics; Osmotic Pressure; Peptidoglycan; Polysaccharides, Bacterial; Proteus mirabilis; Single-Cell Analysis; Vibrio parahaemolyticus

2019
Remodeling of Cross-bridges Controls Peptidoglycan Cross-linking Levels in Bacterial Cell Walls.
    ACS chemical biology, 2020, 05-15, Volume: 15, Issue:5

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Binding Sites; Cell Wall; Cross-Linking Reagents; Diaminopimelic Acid; Drug Design; Enterococcus faecalis; Enterococcus faecium; Peptidoglycan; Peptidoglycan Glycosyltransferase; Peptidyl Transferases; Signal Transduction

2020
Absence of tmRNA Increases the Persistence to Cefotaxime and the Intercellular Accumulation of Metabolite GlcNAc in
    Frontiers in cellular and infection microbiology, 2020, Volume: 10

    Topics: Acetylglucosamine; Aeromonas veronii; Anti-Bacterial Agents; beta-Lactams; Cefotaxime; Drug Resistance, Multiple, Bacterial; Gene Expression Regulation, Bacterial; Microbial Sensitivity Tests; Osmoregulation; Peptidoglycan; Protein Biosynthesis; RNA, Bacterial; Up-Regulation

2020
The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate β-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids.
    International journal of antimicrobial agents, 2021, Volume: 57, Issue:3

    Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Cefoxitin; Cell Wall; DNA, Bacterial; Drug Resistance, Bacterial; Humans; Larva; Lipopolysaccharides; Membrane Proteins; Meropenem; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Animal; Moths; Mutation; Octoxynol; Oxacillin; Penicillin-Binding Proteins; Peptidoglycan; Phenotype; Staphylococcal Infections; Teichoic Acids; Virulence

2021
Click and Release Chemistry for Activity-Based Purification of β-Lactam Targets.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2021, May-17, Volume: 27, Issue:28

    Topics: Anti-Bacterial Agents; beta-Lactams; Carbapenems; Click Chemistry; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases

2021
A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection.
    Nature communications, 2021, 05-07, Volume: 12, Issue:1

    Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Candida albicans; Candidiasis; Cell Wall; Chromatography, Liquid; Female; Gastrointestinal Microbiome; Gram-Negative Bacteria; Humans; Hyphae; Mass Spectrometry; Mice; Mice, Inbred BALB C; Peptidoglycan; Staphylococcal Infections; Staphylococcus aureus

2021
CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution.
    Nature communications, 2021, 05-13, Volume: 12, Issue:1

    Topics: Acetylglucosamine; Aldehydes; Anti-Bacterial Agents; beta-Lactams; Cell Wall; Cryoelectron Microscopy; Escherichia coli; Escherichia coli Proteins; Muramic Acids; Oligosaccharides; Penicillin-Binding Proteins; Peptidoglycan; Peptidoglycan Glycosyltransferase; Protein Conformation; Protein Domains; Serine-Type D-Ala-D-Ala Carboxypeptidase

2021
Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm.
    mSphere, 2022, 02-23, Volume: 7, Issue:1

    Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Penicillin-Binding Proteins; Peptidoglycan

2022
CRISPR Inhibition of Essential Peptidoglycan Biosynthesis Genes in Mycobacterium abscessus and Its Impact on β-Lactam Susceptibility.
    Antimicrobial agents and chemotherapy, 2022, 04-19, Volume: 66, Issue:4

    Topics: Anti-Bacterial Agents; beta-Lactams; Clustered Regularly Interspaced Short Palindromic Repeats; Humans; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Peptidoglycan

2022
Allosteric cooperation in β-lactam binding to a non-classical transpeptidase.
    eLife, 2022, 04-27, Volume: 11

    Topics: Anti-Bacterial Agents; beta-Lactams; Catalytic Domain; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases

2022
Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs.
    eLife, 2022, 06-09, Volume: 11

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Escherichia coli; Isotope Labeling; Mass Spectrometry; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases

2022
Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing.
    Microbiology spectrum, 2022, 08-31, Volume: 10, Issue:4

    Topics: Anti-Bacterial Agents; beta-Lactams; Carbapenems; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Peptidoglycan; Tuberculosis

2022
Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division.
    mBio, 2022, 08-30, Volume: 13, Issue:4

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Division; Cell Wall; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases; Staphylococcal Infections; Staphylococcus aureus

2022
Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance.
    Microbiology spectrum, 2022, 08-31, Volume: 10, Issue:4

    Topics: Alanine; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Carboxypeptidases; Escherichia coli; Peptidoglycan; Vancomycin; Vancomycin Resistance

2022
Development of Whole-Cell Biosensors for Screening of Peptidoglycan-Targeting Antibiotics in a Gram-Negative Bacterium.
    Applied and environmental microbiology, 2022, 09-22, Volume: 88, Issue:18

    Topics: Agar; Ampicillin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Biosensing Techniques; Cell Wall; Cycloserine; Gram-Negative Bacteria; Luciferases, Bacterial; Membrane Transport Proteins; Peptidoglycan; Shewanella; Vancomycin

2022
Analysis of a Cell Wall Mutant Highlights Rho-Dependent Genome Amplification Events in Staphylococcus aureus.
    Microbiology spectrum, 2022, 10-26, Volume: 10, Issue:5

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Gene Amplification; Genome, Bacterial; Microbial Sensitivity Tests; Oxacillin; Peptidoglycan; Staphylococcus aureus

2022
The Roles of the Two-Component System, MtrAB, in Response to Diverse Cell Envelope Stresses in
    Applied and environmental microbiology, 2022, 10-26, Volume: 88, Issue:20

    Topics: Actinobacteria; Actinomycetales; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Ethambutol; Gene Expression Regulation, Bacterial; Isoniazid; Muramidase; Peptidoglycan

2022
Spontaneous Prophage Induction Contributes to the Production of Membrane Vesicles by the Gram-Positive Bacterium
    mBio, 2022, 10-26, Volume: 13, Issue:5

    Topics: Anti-Bacterial Agents; beta-Lactams; Lacticaseibacillus casei; Mitomycins; N-Acetylmuramoyl-L-alanine Amidase; Peptidoglycan; Prophages; Virus Activation

2022
Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of β-lactams.
    Nature communications, 2022, 12-27, Volume: 13, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Escherichia coli; Penicillin-Binding Proteins; Peptidoglycan; Peptidyl Transferases

2022
Mutations in
    mBio, 2023, 04-25, Volume: 14, Issue:2

    Topics: Acetylglucosamine; Antitubercular Agents; Bacterial Proteins; beta-Lactams; Cefuroxime; DNA-Directed RNA Polymerases; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Peptidoglycan; Rifampin; Uridine Diphosphate

2023
Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases.
    The Journal of biological chemistry, 2023, Volume: 299, Issue:4

    Topics: beta-Lactams; Cell Wall; Escherichia coli; Escherichia coli Proteins; Gene Expression; Peptidoglycan; Stress, Physiological

2023
A Decrease in Fatty Acid Synthesis Rescues Cells with Limited Peptidoglycan Synthesis Capacity.
    mBio, 2023, 04-25, Volume: 14, Issue:2

    Topics: Bacterial Proteins; beta-Lactams; Cell Wall; Cerulenin; Penicillin-Binding Proteins; Peptidoglycan

2023