Compounds > beta-lactams
Page last updated: 2024-09-04

beta-lactams and avibactam

beta-lactams has been researched along with avibactam in 21 studies

Compound Research Comparison

Studies
(beta-lactams)		Trials
(beta-lactams)		Recent Studies (post-2010)
(beta-lactams)		Studies
(avibactam)		Trials
(avibactam)		Recent Studies (post-2010) (avibactam)
7,5791793,39536016352

Protein Interaction Comparison

ProteinTaxonomybeta-lactams (IC50)avibactam (IC50)
Beta-lactamaseEnterobacter cloacae0.1
Beta-lactamasePseudomonas aeruginosa PAO10.128
Beta-lactamase TEMEscherichia coli0.0019

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's16 (76.19)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Black, MT; Claudon, M; Girard, AM; Levasseur, P; Miossec, C; Péchereau, MC; Stachyra, T1
Bonomo, RA; Choudhary, Y; Endimiani, A1
DeCorby, M; Hoban, DJ; Karlowsky, JA; Lagacé-Wiens, PR; Simner, P; Tailor, F; Walkty, A; Zhanel, GG1
Abuzenadah, AM; Alam, Q; Azhar, EI; Damanhouri, GA; Jabir, NR; Kamal, MA; Shakil, S; Tabrez, S1
Aktaş, Z; Kayacan, C; Oncul, O1
Benvenuti, M; De Luca, F; Docquier, JD; Durand-Reville, T; Lahiri, SD; Mangani, S; Sanyal, G1
Aoki, K; Ishii, Y; Nichols, WW; Tateda, K; Testa, R; Yoshizumi, A1
Bush, K; Estabrook, M; Jacoby, GA; Li, H; Nichols, WW; Testa, RT1
Abdelhamed, AM; Bajaksouzian, S; Bonomo, RA; Foster, AN; Gatta, JA; Jacobs, MR; Nichols, WW; Papp-Wallace, KM; Testa, R; Winkler, ML1
Cantón, R; Giani, T; Morosini, MI; Nichols, WW; Nordmann, P; Rossolini, GM; Seifert, H; Stefanik, D; Testa, R1
Nord, CE; Panagiotidis, G; Rashid, MU; Rosenborg, S; Söderberg-Löfdal, K; Weintraub, A1
Bradford, PA; Eakin, AE; Harris, JJ; Kim, A; McLaughlin, RE; O'Donnell, JP; Patey, S; Singh, R; Tanudra, MA1
Cattoir, V; Derdouri, S; Dupont, H; Emond, JP; Gaillard, N; Gaillot, O; Girard de Courtilles, M; Goetgheluck, AS; Lecuru, M; Lemaire, B; Mammeri, H; Plassart, C1
Arthur, M; Cortes, M; Dorchêne, D; Dubée, V; Lefebvre, AL; Mainardi, JL1
Huband, MD; McLeod, SM; Nichols, WW; Patey, SA1
Fisher, S; Galanis, C; Gupta, C; Kaushik, A; Lamichhane, G; Parrish, N; Story-Roller, E1
Compain, F; Grohs, P; Mathy, V1
Ammerman, NC; Kaushik, A; Nuermberger, EL; Parrish, NM1
Das, CK; Nair, NN1
Baym, M; Glaser, F; Haldimann, A; Kelsic, ED; Kishony, R; Russ, D; Shaer Tamar, E; Yelin, I; Zampaloni, C1
Dartois, V; Dick, T; Negatu, DA; Zimmerman, MD1

Reviews

1 review(s) available for beta-lactams and avibactam

ArticleYear
New Delhi metallo-β-lactamase (NDM-1): an update.
    Journal of chemotherapy (Florence, Italy), 2011, Volume: 23, Issue:5

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Biotransformation; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Enzyme Inhibitors; Global Health; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Molecular Targeted Therapy; Sulbactam

2011

Trials

1 trial(s) available for beta-lactams and avibactam

ArticleYear
Ecological Effect of Ceftaroline-Avibactam on the Normal Human Intestinal Microbiota.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Ceftaroline; Cephalosporins; Feces; Female; Gastrointestinal Microbiome; Healthy Volunteers; Humans; Male; Microbial Sensitivity Tests; Young Adult

2015

Other Studies

19 other study(ies) available for beta-lactams and avibactam

ArticleYear
In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:2

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporins; Enterobacteriaceae; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure

2009
In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; beta-Lactamases; beta-Lactams; Klebsiella pneumoniae; Microbial Sensitivity Tests

2009
Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5

    Topics: Azabicyclo Compounds; beta-Lactamases; beta-Lactams; Escherichia coli; Klebsiella pneumoniae

2011
In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae.
    International journal of antimicrobial agents, 2012, Volume: 39, Issue:1

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamases; beta-Lactams; Drug Therapy, Combination; Escherichia coli; Gram-Negative Bacteria; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests

2012
Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-lactamases.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:6

    Topics: Acylation; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Crystallization; Humans; Models, Molecular; Molecular Sequence Data; Pseudomonas aeruginosa; Structure-Activity Relationship; X-Ray Diffraction

2013
In vitro susceptibility of characterized β-lactamase-producing Gram-negative bacteria isolated in Japan to ceftazidime-, ceftaroline-, and aztreonam-avibactam combinations.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2015, Volume: 21, Issue:2

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamases; beta-Lactams; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Japan; Microbial Sensitivity Tests

2015
In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:3

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Drug Therapy, Combination; Gram-Negative Bacteria

2015
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.
    Diagnostic microbiology and infectious disease, 2015, Volume: 82, Issue:1

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Ceftaroline; Ceftazidime; Cephalosporins; Escherichia coli; Humans; Microbial Sensitivity Tests

2015
In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates.
    International journal of antimicrobial agents, 2015, Volume: 45, Issue:6

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Europe; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitals; Humans; Microbial Sensitivity Tests

2015
Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamase Inhibitors; beta-Lactams; Disease Models, Animal; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Mice; Microbial Sensitivity Tests; Models, Biological; Treatment Outcome

2015
Molecular Characterization of Carbapenem-Nonsusceptible Enterobacterial Isolates Collected during a Prospective Interregional Survey in France and Susceptibility to the Novel Ceftazidime-Avibactam and Aztreonam-Avibactam Combinations.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; Bacterial Outer Membrane Proteins; beta-Lactamases; beta-Lactams; Ceftazidime; Dipeptides; Drug Combinations; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Epidemiological Monitoring; Ertapenem; France; Gene Expression; Humans; Microbial Sensitivity Tests; Plasmids; Prevalence; Prospective Studies

2016
Bactericidal and intracellular activity of β-lactams against Mycobacterium abscessus.
    The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:6

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Cells, Cultured; Drug Interactions; Humans; Macrophages; Microbial Viability; Nontuberculous Mycobacteria

2016
Impact of defined cell envelope mutations in Escherichia coli on the in vitro antibacterial activity of avibactam/β-lactam combinations.
    International journal of antimicrobial agents, 2017, Volume: 49, Issue:4

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Cell Membrane; Cell Wall; Escherichia coli; Gene Deletion; Lipopolysaccharides; Microbial Sensitivity Tests; Mutation; Porins

2017
Combinations of avibactam and carbapenems exhibit enhanced potencies against drug-resistant Mycobacterium abscessus.
    Future microbiology, 2017, Volume: 12

    Topics: Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Carbapenems; Drug Resistance, Multiple, Bacterial; Ertapenem; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Thienamycins

2017
In vitro activity of β-lactams in combination with avibactam against multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Achromobacter xylosoxidans isolates from patients with cystic fibrosis.
    Journal of medical microbiology, 2018, Volume: 67, Issue:9

    Topics: Achromobacter denitrificans; Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactams; Cystic Fibrosis; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Stenotrophomonas maltophilia

2018
New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:9

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Cefepime; Cyclooctanes; Microbial Sensitivity Tests; Mycobacterium abscessus; Piperidines

2019
Elucidating the Molecular Basis of Avibactam-Mediated Inhibition of Class A β-Lactamases.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2020, Aug-03, Volume: 26, Issue:43

    Topics: Acylation; Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Catalytic Domain; Gram-Negative Bacteria; Kinetics; Molecular Dynamics Simulation

2020
Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor.
    Nature communications, 2020, 04-24, Volume: 11, Issue:1

    Topics: Amino Acid Substitution; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Drug Resistance, Multiple, Bacterial; Escherichia coli; Evolution, Molecular; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Docking Simulation; Mutation

2020
Strongly Bactericidal All-Oral β-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease.
    Antimicrobial agents and chemotherapy, 2022, 09-20, Volume: 66, Issue:9

    Topics: Amoxicillin; Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Cefuroxime; Humans; Lactams; Lung Diseases; Microbial Sensitivity Tests; Mycobacterium abscessus

2022