beta-ionone and gallein

beta-ionone has been researched along with gallein* in 1 studies

Other Studies

1 other study(ies) available for beta-ionone and gallein

ArticleYear
Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand.
    BMC research notes, 2017, Oct-30, Volume: 10, Issue:1

    We previously reported that the olfactory receptor OR51E2, overexpressed in LNCaP prostate cancer cells, promotes cell invasiveness upon stimulation of its agonist β-ionone, and this phenomenon increases metastatic spread. Furthermore, we showed that the induced cell invasiveness involves a PI3 kinase dependent signalling pathway. We report here the results of a new investigation to address whether gallein, a small inhibitor of G protein βγ subunit interaction with PI3 kinase, can inhibit β-ionone effects both in vitro and in vivo.. We demonstrate that gallein can inhibit the β-ionone-induced cell invasiveness in vitro, as well as the spread of metastases in vivo. LNCaP cell invasiveness, assessed using spheroid cultures in collagen gels in vitro, was increased by β-ionone and the effect was reversed by co-administration of gallein. LNCaP tumour cells, subcutaneously inoculated to immunodeficient mice, generated more metastases in vivo when β-ionone was applied through the skin. Furthermore, the intraperitoneal injection of gallein inhibited this increased metastasis spread. Our results thus support the role of OR51E2 in the β-ionone observed effects, and suggest that gallein could be a potential new agent in personalized medicine of the tumours expressing OR51E2.

    Topics: Animals; Cell Line, Tumor; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Humans; Male; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Norisoprenoids; Prostatic Neoplasms; Receptors, Odorant; Signal Transduction; Tumor Cells, Cultured; Xanthenes

2017