beta-ionone and 1-2-dioleoyloxy-3-(trimethylammonium)propane

β-ionone (ION) is a cyclic terpenoid compound that demonstrates considerable potential for the prevention and treatment of cancer. However, the water solubility of β-ionone is poor and the compound demonstrates low permeability. Liposomes have been reported as increasing both qualities. In this study, the development of β-ionone liposomes was initiated by adding 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) to produce cationic liposomes as a means of enhancing binding to cancer cells. Liposomes composed of β-ionone, HSPC, cholesterol, and DSPE-mPEG

Topics: Fatty Acids, Monounsaturated; HeLa Cells; Humans; Liposomes; Propane; Quaternary Ammonium Compounds