beta-hydroxyisovalerylshikonin has been researched along with naphthoquinones in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 10 (66.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Aiuchi, T; Cao, J; Hashimoto, S; Ida, Y; Masuda, Y; Miyakoshi, M; Nakajo, S; Nakaya, K; Xu, M | 1 |
| Nakajo, S; Nakaya, K; Xu, Y | 1 |
| Asaka, M; Hirabayashi, T; Hori, K; Kajimoto, S; Kondo, T; Masuda, Y; Nakajo, S; Nakaya, K; Nishida, A | 1 |
| Aiuchi, T; Hashimoto, S; Masuda, Y; Nakajo, S; Nakaya, K; Shibuya, M; Uehara, Y; Xu, Y; Yamori, T | 1 |
| Miyasaka, T; Nakaya, K | 1 |
| Kajimoto, S; Nakajo, S; Nakaya, K; Xu, Y | 1 |
| Aiuchi, T; Hori, K; Horie, M; Kajimoto, S; Masuda, Y; Nakajo, S; Nakaya, K; Shibayama-Imazu, T; Shima, G | 1 |
| Narahara, H; Nasu, K; Nishida, M; Takai, N; Ueda, T; Yuge, A | 1 |
| Gong, XF; Horie, M; Itabe, H; Kajimoto, S; Manabe, H; Masuda, Y; Nakajo, S; Nakaya, K; Obama, T; Shibayama-Imazu, T | 1 |
| Narahara, H; Nasu, K; Nishida, M; Takai, N; Ueda, T | 1 |
| Itabe, H; Kajimoto, S; Kojima, S; Komi, Y; Masuda, M; Nakajo, S; Nakaya, K; Oettgen, P; Shibuya, M; Shimamura, M; Shimokado, K; Suzuki, Y | 1 |
| Li, SS; Liu, X; Rao, Z; Yi, J; Zhou, W | 1 |
| Choi, YH; Jayasooriya, RG; Jeong, JW; Kim, GY; Lee, HJ; Lee, KT | 1 |
| Chung, SI; Ha, JH; Jang, J; Yoon, Y | 1 |
| Bei, C; Chen, X; Gao, W; Gu, M; Jin, J; Pan, Z; Ren, C; Sun, L; Tian, N; Wang, X; Wu, A; Wu, Y; Zhang, X; Zhou, Y | 1 |
1 review(s) available for beta-hydroxyisovalerylshikonin and naphthoquinones
| Article | Year |
|---|---|
A shikonin derivative, beta-hydroxyisovalerylshikonin, is an ATP-non-competitive inhibitor of protein tyrosine kinases.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzamides; Drug Interactions; Humans; Imatinib Mesylate; K562 Cells; Naphthoquinones; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Structure-Activity Relationship | 2003 |
14 other study(ies) available for beta-hydroxyisovalerylshikonin and naphthoquinones
| Article | Year |
|---|---|
beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide.
Topics: Antineoplastic Agents; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspases; Cell Division; DNA Fragmentation; Drug Screening Assays, Antitumor; Enzyme Activation; Etoposide; fas Receptor; HL-60 Cells; Humans; Naphthoquinones; Nucleic Acid Synthesis Inhibitors; Signal Transduction; Tumor Cells, Cultured | 1999 |
Synergistic inhibitory effects of transplatin and beta-hydroxyisovalerylshikon on carcinoma A431 cells involve epidermal growth factor receptor.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Synergism; ErbB Receptors; Humans; Naphthoquinones; Oncogene Protein pp60(v-src); Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2002 |
Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1).
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzamides; Cell Cycle Proteins; Cell Line; Cysteine Proteinase Inhibitors; DNA, Complementary; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genistein; HL-60 Cells; Humans; Imatinib Mesylate; K562 Cells; Kidney; Leukemia, Myeloid; Naphthoquinones; Neoplasm Proteins; Oligodeoxyribonucleotides, Antisense; Oligonucleotide Array Sequence Analysis; Phosphorylation; Piperazines; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; U937 Cells | 2003 |
Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cell Death; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Kinetics; Mice; Models, Chemical; Naphthoquinones; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 2002 |
Beta-hydroxyisovalerylshikonin and cisplatin act synergistically to inhibit growth and to induce apoptosis of human lung cancer DMS114 cells via a tyrosine kinase-dependent pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cisplatin; Drug Synergism; Humans; In Situ Nick-End Labeling; Lung Neoplasms; Naphthoquinones; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 2004 |
Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Line, Tumor; Coloring Agents; Cytochromes c; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Gene Expression Regulation; Genetic Vectors; HL-60 Cells; HSP90 Heat-Shock Proteins; Humans; K562 Cells; Mitochondria; Naphthoquinones; Oligonucleotide Array Sequence Analysis; Plasmids; Reactive Oxygen Species; RNA, Small Interfering; Subcellular Fractions; Time Factors; Transfection | 2004 |
Beta-hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study.
Topics: Apoptosis; Bromodeoxyuridine; Cell Cycle; Cell Division; Cell Survival; DNA Fragmentation; Endometriosis; Female; G1 Phase; G2 Phase; Humans; In Vitro Techniques; Naphthoquinones; Premenopause; Resting Phase, Cell Cycle; S Phase; Stromal Cells | 2006 |
A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity.
Topics: Amino Acid Sequence; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxyuracil Nucleotides; Enzyme Activation; Fluorouracil; Humans; Lung Neoplasms; Molecular Sequence Data; Naphthoquinones; Phosphoproteins; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrophosphatases; RNA, Small Interfering | 2008 |
Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Endometrial Neoplasms; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Potential, Mitochondrial; Naphthoquinones; Ovarian Neoplasms; Up-Regulation | 2008 |
Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blotting, Western; Carcinoma, Lewis Lung; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Chickens; Chorioallantoic Membrane; Drugs, Chinese Herbal; Electrophoretic Mobility Shift Assay; Female; Immunoenzyme Techniques; Immunoprecipitation; Luciferases; Mice; Mice, Inbred C57BL; Naphthoquinones; Neovascularization, Pathologic; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Synthesis and antitumour activity of β-hydroxyisovalerylshikonin analogues.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Naphthoquinones; Structure-Activity Relationship | 2011 |
Anti-inflammatory effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway.
Topics: Animals; Cell Line; Dinoprostone; Heme Oxygenase-1; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Mice; Microglia; Molecular Structure; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidines; Thiocarbamates | 2014 |
AMPK and SREBP-1c mediate the anti-adipogenic effect of β-hydroxyisovalerylshikonin.
Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Aldehyde Oxidoreductases; AMP-Activated Protein Kinases; Animals; Cell Survival; Mice; Naphthoquinones; Reverse Transcriptase Polymerase Chain Reaction; Stearoyl-CoA Desaturase; Sterol Regulatory Element Binding Protein 1 | 2016 |
β-Hydroxyisovalerylshikonin inhibits IL-1β-induced chondrocyte inflammation
Topics: Animals; Anti-Inflammatory Agents; Chondrocytes; Heme Oxygenase-1; Humans; Interleukin-1beta; Male; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Osteoarthritis | 2020 |