beta-hydroxyisovaleric acid has been researched along with leucine in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (14.81) | 18.7374 |
| 1990's | 9 (16.67) | 18.2507 |
| 2000's | 4 (7.41) | 29.6817 |
| 2010's | 31 (57.41) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Mock, DM; Mock, NI | 1 |
| Chalmers, RA; Halliday, D; Thompson, GN | 1 |
| Nissen, S; Van Koevering, M | 1 |
| Inoue, Y; Iwasaki, R; Kuhara, T; Matsumoto, I; Morimoto, S; Yu, WM | 1 |
| Nissen, S; Van Koevering, M; Webb, D | 1 |
| Beaudet, AL; Craigen, WJ; Gibson, KM; Johnston, K; Kamali, V; Lee, CF; Powell, BR; Schwartz, R; Tsai, MY; Tuchman, M | 1 |
| Inoue, F; Maltby, DA; Millington, DS; Roe, CR | 1 |
| Cann, HM; Gibson, KM; Greene, CL; Holm, J; Nyhan, WL; Robinson, BH; Sweetman, L | 1 |
| Beemer, FA; Bruinvis, L; Duran, M; Ketting, D; Tibosch, AS; Wadman, SK | 1 |
| Jakobs, C; Nyhan, WL; Packman, S; Sweetman, L | 1 |
| Hine, DG; Tanaka, K | 1 |
| Hokland, B; Spydevold, O | 1 |
| Berry, HK; Denton, MD; Norman, EJ | 1 |
| Inoue, Y; Kameyama, J; Momoi, T; Shigematsu, Y; Sudo, M; Suzuki, Y | 1 |
| Bain, MS; Burns, SP; Chalmers, RA; Holmes, HC; Iles, RA | 1 |
| Abumrad, N; Connelly, AS; Fuller, JC; Nissen, S; Rathmacher, JA; Ray, M; Rice, D; Sharp, R | 1 |
| Kreider, RB | 1 |
| Dreifort, GD; Vukovich, MD | 1 |
| de Almeida, IT; Duran, M; Maya, M; Overmars, H; Selhorst, J; Silva, MF; van Gennip, AH; Wanders, RJ | 1 |
| Carnell, N; Henrich, CL; Mock, DM; Mock, NI | 1 |
| Engelke, UF; Kluijtmans, LA; Kremer, B; Loss, S; Loupatty, FJ; Morava, E; Moskau, D; van den Bergh, E; van der Graaf, M; Wanders, RJ; Wevers, RA | 1 |
| de Siqueira Filho, MA; Felitti, V; Gerlinger-Romero, F; Guimarães-Ferreira, L; Lancha, AH; Lira, FS; Seelaender, M; Zanchi, NE | 1 |
| Holecek, M; Kovarik, M; Muthny, T; Sispera, L | 1 |
| Bogusiewicz, A; Boysen, G; Dawson, AM; Henrich, CL; Horvath, TD; Matthews, NI; Mock, DM; Moran, JH; Owen, SN; Spencer, HJ; Stratton, SL | 1 |
| de Almeida, IT; Diogo, L; Duran, M; Garcia, P; IJlst, L; Luís, PB; Ruiter, JP; Silva, MF; Wanders, RJ | 1 |
| Atherton, PJ; Breen, L; Churchward-Venne, TA; Crossland, H; Etheridge, T; Hill, DS; Hossain, T; Loughna, P; Phillips, BE; Phillips, SM; Rathmacher, JA; Smith, K; Szewczyk, NJ; Wilkinson, DJ; Williams, J | 1 |
| Barillaro, C; Landi, F; Liperoti, R; Martone, AM; Onder, G | 1 |
| Aoki, MS; Artioli, GG; Baptista, IL; Guilherme, JP; Leal, ML; Miyabara, EH; Moriscot, AS; Silva, WJ | 1 |
| Boutry, C; Davis, SR; Davis, TA; El-Kadi, SW; Nguyen, HV; Orellana, RA; Suryawan, A; Wheatley, SM | 1 |
| Bruckbauer, A; Zemel, MB | 1 |
| Barranco, A; Navalón, A; Ramírez, M; Rueda, R; Santos-Fandila, A; Zafra-Gómez, A | 1 |
| Brett, SJ; Frost, G; Hickson, M; Wandrag, L | 1 |
| Caudill, MA; Gayle, A; Jiang, X; Lucas, LK; Malysheva, O; Perry, CA; West, AA; Yan, J | 1 |
| Beno, DW; Edens, NK; Lee, AJ; Mason, M; Mason-Bright, T; Shapiro, R; Surber, B; Zhang, X | 1 |
| Bueno-Vargas, P; López-Pedrosa, JM; Ramírez, M; Santos-Fandila, A; Zafra-Gómez, A | 1 |
| Phillips, SM | 1 |
| Balakrishnan, G; Pereira, SL; Puthan, JK; Ramesh, S; Reddy, MT; Shreeram, S; Subramanian, R | 1 |
| Jayakumar, J; Kuriyan, R; Kurpad, AV; Lokesh, DP; Philip, MG; Selvam, S; Shreeram, S | 1 |
| Bach, E; Hansen, J; Jensen, E; Jessen, N; Johannsen, M; Jørgensen, JO; Møller, AB; Møller, N; Richelsen, B; Rittig, N; Serena, A; Thomsen, HH | 1 |
| Bacci, ML; Barone, F; Elmi, A; Laghi, L; Romagnoli, N; Ventrella, D | 1 |
| Gerlinger-Romero, F; Guimarães-Ferreira, L; Nunes, MT; Salgueiro, RB; Yonamine, CY | 1 |
| Cruz-Jentoft, AJ | 1 |
| Brown, AD; Close, GL; Sharples, AP; Stewart, CE | 1 |
| Chen, X; Duan, Y; Guo, Q; Li, F; Wang, W; Wen, C; Yin, Y; Zhang, L | 1 |
| Buddington, KK; Buddington, RK; Howard, SC; Lee, HW | 1 |
| Jakubowski, JS; McGlory, C; Morton, RW; Murphy, KT; Noguchi, KS; Nunes, EA; Phillips, SM; Vandeweerd, JK; Wong, EPT | 1 |
| Calvani, R; Landi, F; Marzetti, E; Picca, A | 1 |
| Deng, J; Duan, Y; Li, F; Zeng, L; Zhong, Y | 1 |
| Deng, J; Duan, Y; Kong, X; Li, F; Song, B; Zheng, C; Zhong, Y | 1 |
| Alves, F; Matias, CN; Monteiro, CP; Morton, RW; Phillips, SM; Reis, JF; Sardinha, LB; Teixeira, FJ; Valamatos, MJ | 1 |
| Holeček, M; Vodeničarovová, M | 1 |
| Duan, Y; Kong, X; Li, F; Song, B; Xu, K; Zheng, C; Zhong, Y | 1 |
| Banfield, L; Jakubowski, JS; Morton, RW; Nunes, EA; Phillips, SM; Teixeira, FJ; Vescio, V | 1 |
| Bautmans, I; Beckwée, D; De Breucker, S; Delaere, A; Gielen, E; Vandewoude, M | 1 |
9 review(s) available for beta-hydroxyisovaleric acid and leucine
| Article | Year |
|---|---|
Dietary supplements and the promotion of muscle growth with resistance exercise.
Topics: Anabolic Agents; Boron; Chromium; Creatine; Dehydroepiandrosterone; Dietary Carbohydrates; Dietary Proteins; Dietary Supplements; Glutamine; Humans; Leucine; Muscle Development; Muscle, Skeletal; Nutritional Physiological Phenomena; Protein Biosynthesis; Testosterone; Valerates; Vanadium Compounds; Weight Lifting | 1999 |
HMB supplementation: clinical and athletic performance-related effects and mechanisms of action.
Topics: Administration, Oral; Adult; Athletic Performance; Body Composition; Dietary Supplements; Humans; Keto Acids; Leucine; Male; Muscle Strength; Muscle, Skeletal; Resistance Training; Signal Transduction; Valerates | 2011 |
The new metabolic treatments for sarcopenia.
Topics: Animals; Humans; Leucine; Sarcopenia; Valerates; Vitamin D | 2013 |
Impact of supplementation with amino acids or their metabolites on muscle wasting in patients with critical illness or other muscle wasting illness: a systematic review.
Topics: Aged; Amino Acids; Amino Acids, Essential; Body Composition; Creatine; Critical Illness; Diet; Dietary Supplements; Enteral Nutrition; Female; Humans; Intensive Care Units; Leucine; Male; MEDLINE; Muscular Atrophy; Nutritional Status; Valerates | 2015 |
Nutritional supplements in support of resistance exercise to counter age-related sarcopenia.
Topics: Aged; Aging; Creatine; Diet; Dietary Proteins; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Leucine; Male; Muscle Strength; Muscle, Skeletal; Quality of Life; Resistance Training; Sarcopenia; Valerates | 2015 |
Beta-Hydroxy-Beta-Methyl Butyrate (HMB): From Experimental Data to Clinical Evidence in Sarcopenia.
Topics: Aged; Aged, 80 and over; Aging; Apoptosis; Cell Survival; Dietary Supplements; Frailty; Humans; Leucine; Middle Aged; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Sarcopenia; Valerates | 2018 |
Beta-hydroxy-beta-methylbutyrate and sarcopenia: from biological plausibility to clinical evidence.
Topics: Aged; Dietary Supplements; Frail Elderly; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Physical Functional Performance; Sarcopenia; Valerates | 2019 |
Supplementation with the Leucine Metabolite β-hydroxy-β-methylbutyrate (HMB) does not Improve Resistance Exercise-Induced Changes in Body Composition or Strength in Young Subjects: A Systematic Review and Meta-Analysis.
Topics: Adolescent; Adult; Body Composition; Body Mass Index; Databases, Factual; Dietary Supplements; Female; Humans; Leucine; Male; Muscle Strength; Muscle, Skeletal; Randomized Controlled Trials as Topic; Resistance Training; Sensitivity and Specificity; Valerates; Young Adult | 2020 |
Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses.
Topics: Aged; Aged, 80 and over; Amino Acids, Essential; Creatine; Dietary Supplements; Exercise; Humans; Leucine; Muscle Strength; Muscle, Skeletal; Physical Functional Performance; Sarcopenia; Valerates | 2021 |
7 trial(s) available for beta-hydroxyisovaleric acid and leucine
| Article | Year |
|---|---|
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training.
Topics: Adult; Body Composition; Body Weight; Diet; Dietary Fats; Dietary Proteins; Energy Metabolism; Humans; Leucine; Male; Methylhistidines; Muscle Proteins; Muscle, Skeletal; Physical Education and Training; Valerates; Weight Lifting | 1996 |
Effect of beta-hydroxy beta-methylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists.
Topics: Adult; Anaerobic Threshold; Analysis of Variance; Bicycling; Blood Glucose; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Exercise; Hematocrit; Hemoglobins; Humans; Lactates; Leucine; Male; Oxygen Consumption; Physical Education and Training; Physical Endurance; Time Factors; Valerates | 2001 |
Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
Topics: Adult; Biomarkers; Biotin; Carbon-Carbon Ligases; Carnitine; Choline; Chromatography, Liquid; Diet; Dietary Supplements; Female; Humans; Lactation; Leucine; Milk, Human; New York; Patient Compliance; Pregnancy; Tandem Mass Spectrometry; Valerates; Young Adult | 2014 |
Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial.
Topics: Adaptor Proteins, Signal Transducing; Adult; Anabolic Agents; Body Mass Index; Cell Cycle Proteins; Cross-Over Studies; Dietary Carbohydrates; Fasting; Glucagon; Humans; Leucine; Male; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Soybean Proteins; TOR Serine-Threonine Kinases; Valerates; Whey Proteins; Young Adult | 2017 |
Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men.
Topics: Adult; Biopsy; Body Composition; Creatine Kinase; Dietary Supplements; Double-Blind Method; Human Growth Hormone; Humans; Hydrocortisone; Insulin-Like Growth Factor I; Leucine; Male; Muscle Strength; Muscle, Skeletal; Performance-Enhancing Substances; Resistance Training; Testosterone; Ultrasonography; Valerates; Young Adult | 2019 |
α-Ketoisocaproate and β-hydroxy-β-methyl butyrate regulate fatty acid composition and lipid metabolism in skeletal muscle of growing pigs.
Topics: AMP-Activated Protein Kinases; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet; Fatty Acids; Gene Expression Regulation; Keto Acids; Leucine; Lipid Metabolism; Muscle, Skeletal; Random Allocation; RNA, Messenger; Swine; TOR Serine-Threonine Kinases; Transcription Factors; Valerates | 2019 |
Leucine metabolites do not attenuate training-induced inflammation in young resistance trained men.
Topics: Adult; Biomarkers; Body Composition; C-Reactive Protein; Calcium; Caproates; Dietary Supplements; Double-Blind Method; Humans; Inflammation; Interleukin-6; Leucine; Male; Muscle Strength; Muscle, Skeletal; Resistance Training; Sports Nutritional Physiological Phenomena; Tumor Necrosis Factor-alpha; Valerates; Young Adult | 2019 |
38 other study(ies) available for beta-hydroxyisovaleric acid and leucine
| Article | Year |
|---|---|
Biotin deficiency in rats: disturbances of leucine metabolism are detectable early.
Topics: Animals; Biotin; Gas Chromatography-Mass Spectrometry; Leucine; Male; Rats; Rats, Inbred Strains; Valerates | 1992 |
The contribution of protein catabolism to metabolic decompensation in 3-hydroxy-3-methylglutaric aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Diseases in Twins; Female; Glutarates; Humans; Leucine; Male; Meglutol; Oxo-Acid-Lyases; Phenylalanine; Proteins; Valerates | 1990 |
Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo.
Topics: Animals; Female; Keto Acids; Leucine; Male; Osmolar Concentration; Oxidation-Reduction; Sheep; Swine; Valerates | 1992 |
Increased urinary excretion of beta-hydroxyisovaleric acid in ketotic and non-ketotic type II diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Gas Chromatography-Mass Spectrometry; Glycosuria; Humans; Leucine; Male; Middle Aged; Trimethylsilyl Compounds; Valerates | 1990 |
Analysis of beta-hydroxy-beta-methyl butyrate in plasma by gas chromatography and mass spectrometry.
Topics: Animals; Buffers; Caproates; Gas Chromatography-Mass Spectrometry; Leucine; Reference Standards; Sheep; Valerates | 1990 |
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency as detected by radiochemical assay in cell extracts by thin-layer chromatography, and identification of three new cases.
Topics: Cells, Cultured; Chromatography, Thin Layer; Dicarboxylic Acids; Fibroblasts; Humans; Infant; Infant, Newborn; Leucine; Lymphocytes; Male; Oxidation-Reduction; Oxo-Acid-Lyases; Radiochemistry; Valerates | 1990 |
Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Dietary Proteins; Glycine; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Valerates | 1987 |
3-Hydroxy-3-methylglutaric aciduria.
Topics: Cells, Cultured; Female; Fibroblasts; Follow-Up Studies; Glutarates; Humans; Infant, Newborn; Leucine; Meglutol; Oxo-Acid-Lyases; Skin; Valerates | 1984 |
Inherited 3-methylglutaconic aciduria in two brothers--another defect of leucine metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Glutarates; Humans; Hydro-Lyases; Leucine; Male; Meglutol; Speech Disorders; Valerates | 1982 |
Stable isotope dilution analysis of 3-hydroxyisovaleric acid in amniotic fluid: contribution to the prenatal diagnosis of inherited disorders of leucine catabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Amniocentesis; Amniotic Fluid; Carboxy-Lyases; Female; Humans; Leucine; Pregnancy; Prenatal Diagnosis; Valerates | 1984 |
The identification and the excretion pattern of isovaleryl glucuronide in the urine of patients with isovaleric acidemia.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Glucuronates; Glycine; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Valerates | 1984 |
Release of leucine and isoleucine metabolites by perfused skeletal muscle and liver of rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Female; Hydroxybutyrates; Isoleucine; Keto Acids; Lactates; Lactic Acid; Leucine; Liver; Muscles; Rats; Rats, Inbred Strains; Valerates | 1983 |
Gas-chromatographic/mass spectrometric detection of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in double first cousins.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Gas Chromatography-Mass Spectrometry; Glutarates; Humans; Hydroxy Acids; Infant; Leucine; Male; Meglutol; Oxo-Acid-Lyases; Valerates | 1982 |
Changing plasma and urinary organic acid levels in a patient with isovaleric acidemia during an attack.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Female; Glycine; Hemiterpenes; Humans; Hydroxybutyrates; Leucine; Pentanoic Acids; Valerates | 1982 |
Ketogenic flux from lipids and leucine, assessment in 3-hydroxy-3-methylglutaryl CoA lyase deficiency.
Topics: Carnitine; Child; Humans; Ketone Bodies; Leucine; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Oxo-Acid-Lyases; Valerates | 1995 |
Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carnitine; Female; Humans; Leucine; Male; Middle Aged; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Spectrometry, Mass, Electrospray Ionization; Valerates; Valproic Acid | 2001 |
Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge.
Topics: Adult; Biotin; Diet; Dose-Response Relationship, Drug; Egg White; Female; Humans; Leucine; Male; Time Factors; Valerates | 2002 |
NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Female; Glutarates; Humans; Leucine; Magnetic Resonance Spectroscopy; Meglutol; Middle Aged; Valerates | 2006 |
Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats.
Topics: Animals; Cathepsin B; Cathepsin L; Leucine; Lysosomes; Male; Muscle, Skeletal; Oxygen; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Sepsis; Time Factors; Valerates | 2010 |
Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.
Topics: Adult; Biotin; Carnitine; Cohort Studies; Female; Humans; Leucine; Male; Valerates | 2011 |
Inhibition of 3-methylcrotonyl-CoA carboxylase explains the increased excretion of 3-hydroxyisovaleric acid in valproate-treated patients.
Topics: Biotinidase; Carbon-Carbon Ligases; Case-Control Studies; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Humans; Inhibitory Concentration 50; Kinetics; Leucine; Liver; Metabolomics; Models, Chemical; Valerates; Valproic Acid | 2012 |
Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism.
Topics: Administration, Oral; Humans; Leucine; Male; Muscle, Skeletal; Protein Biosynthesis; Proteolysis; Tissue Distribution; Valerates; Young Adult | 2013 |
Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions.
Topics: Animals; Dietary Supplements; Hindlimb Suspension; Leucine; Male; Muscle, Skeletal; Organ Size; Phosphatidylinositol 3-Kinases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Rats; Sarcopenia; Valerates | 2013 |
Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of β-hydroxy-β-methylbutyrate.
Topics: Animals; Animals, Newborn; Autophagy; Leucine; Muscle Proteins; Muscle, Skeletal; Peptide Initiation Factors; Phosphorylation; Protein Biosynthesis; Signal Transduction; Sus scrofa; TOR Serine-Threonine Kinases; Valerates | 2014 |
Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Caffeic Acids; Chlorogenic Acid; Ellagic Acid; Fatty Acids; Humans; Leucine; Mice; Muscle Cells; NAD; Oxidation-Reduction; Phosphodiesterase Inhibitors; Polyphenols; Protein Kinase Inhibitors; Resveratrol; Sirtuin 1; Stilbenes; Valerates; Xanthines | 2014 |
Quantitative determination of β-hydroxymethylbutyrate and leucine in culture media and microdialysates from rat brain by UHPLC-tandem mass spectrometry.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Cattle; Chromatography, High Pressure Liquid; Culture Media; Leucine; Microdialysis; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Valerates | 2014 |
A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dipeptides; Intestinal Absorption; Keto Acids; Leucine; Male; Mass Spectrometry; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Valerates | 2015 |
Quantification of β-hydroxymethylbutyrate and leucine by ultrahigh performance liquid chromatography tandem mass spectrometry at different situations and stages of a rodent life.
Topics: Animals; Animals, Newborn; Brain Chemistry; Chromatography, High Pressure Liquid; Fasting; Female; Lactation; Leucine; Limit of Detection; Male; Milk; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Valerates | 2015 |
Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aging; Animals; Dietary Supplements; Humans; Keto Acids; Leucine; Liver; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Valerates | 2016 |
The relationship of endogenous plasma concentrations of β-Hydroxy β-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans.
Topics: Absorptiometry, Photon; Adolescent; Adult; Age Factors; Aged; Anthropometry; Body Composition; Child; Dietary Supplements; Female; Hand Strength; Humans; India; Leucine; Male; Middle Aged; Muscle, Skeletal; Valerates | 2016 |
Age-Related 1H NMR Characterization of Cerebrospinal Fluid in Newborn and Young Healthy Piglets.
Topics: Adenine; Animals; Animals, Newborn; Blood-Brain Barrier; Cerebrospinal Fluid; Creatinine; Crosses, Genetic; Female; Glutamine; Inositol; Leucine; Magnetic Resonance Spectroscopy; Metabolomics; Methylamines; Pentanoic Acids; Principal Component Analysis; Swine; Tyrosine; Valerates; Valine | 2016 |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on the expression of ubiquitin ligases, protein synthesis pathways and contractile function in extensor digitorum longus (EDL) of fed and fasting rats.
Topics: Animals; Carrier Proteins; Fasting; Leucine; Ligases; Male; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Rats; Rats, Wistar; Ubiquitin; Valerates | 2018 |
Murine myoblast migration: influence of replicative ageing and nutrition.
Topics: Animals; Cell Movement; Cells, Cultured; Cellular Senescence; Leucine; Mice; Muscle, Skeletal; Myoblasts; Nutritional Status; Signal Transduction; Valerates | 2017 |
β-Hydroxy-β-methyl Butyrate Is More Potent Than Leucine in Inhibiting Starvation-Induced Protein Degradation in C2C12 Myotubes.
Topics: Animals; Cell Line; Insulin; Keto Acids; Leucine; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Phosphatidylinositol 3-Kinases; Proteolysis; Proto-Oncogene Proteins c-akt; SKP Cullin F-Box Protein Ligases; TOR Serine-Threonine Kinases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Valerates | 2018 |
Growth Responses of Preterm Pigs Fed Formulas with Different Protein Levels and Supplemented with Leucine or β-Hydroxyl β-Methylbutyrate.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Birth Weight; Diet, High-Protein; Diet, Protein-Restricted; Dietary Proteins; Dietary Supplements; Female; Gestational Age; Leucine; Male; Nutritional Status; Parenteral Nutrition; Premature Birth; Sex Factors; Sus scrofa; Valerates; Weight Gain | 2018 |
β-hydroxy-β-methylbutyrate (HMB) improves mitochondrial function in myocytes through pathways involving PPARβ/δ and CDK4.
Topics: Animals; Cell Culture Techniques; Cyclin-Dependent Kinase 4; Humans; Leucine; Mitochondria; Muscle Cells; PPAR gamma; PPAR-beta; Signal Transduction; Valerates | 2019 |
Effects of beta-hydroxy-beta-methylbutyrate supplementation on skeletal muscle in healthy and cirrhotic rats.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Dietary Supplements; Leucine; Liver; Liver Cirrhosis; Muscle, Skeletal; Rats, Wistar; Valerates | 2019 |
Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.
Topics: Animals; Leucine; Mice; Muscle Fibers, Skeletal; Proteolysis; Valerates | 2019 |