beta-escin has been researched along with gamma-sitosterol* in 1 studies
1 other study(ies) available for beta-escin and gamma-sitosterol
| Article | Year |
|---|---|
Topical hydrogels with escin β-sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity.
The physicochemical properties, stability, in vivo antihyperalgesic activity, and skin irritation potential of the carbomer hydrogels with the new chemical entity escin β-sitosterol (ES) phytosome were characterized and compared with those containing escin. Physicochemical characterization of the hydrogels (performed 48 hr after preparation) included organoleptic examination, pH measurement, light microscopy, differential scanning calorimetry analysis and rheological tests. The obtained results showed that increasing concentration of the active substances within 1-5% affected the appearance (color and transparency) of the hydrogels, their pH, consistency, and rheological behavior. Unlike acidic escin, which was dissolved in the liquid phase of the pseudoplastic hydrogels E1-E5 and reduced their maximal apparent viscosity (η Topics: Administration, Cutaneous; Animals; Chemical Phenomena; Dose-Response Relationship, Drug; Drug Compounding; Drug Stability; Escin; Hydrogels; Male; Pain Measurement; Rats; Sitosterols | 2019 |