Page last updated: 2024-08-25

berberrubine and berberine

berberrubine has been researched along with berberine in 50 studies

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.00)	18.2507
2000's	10 (20.00)	29.6817
2010's	26 (52.00)	24.3611
2020's	13 (26.00)	2.80

Authors

Authors	Studies
Czerniecki, NJ; Douglas, KA; Grundt, P; Krivogorsky, B; Pernat, JA	1
Chung, IK; Kim, JH; Kim, SA; Kwon, Y; Muller, MT	1
Hong, SW; Jeun, JA; Kim, JH; Kim, SH; Kim, SU; Lee, SJ	1
Chung, IK; Kang, MR	1
Kim, JH; Kim, SH; Lee, JH; Lee, SJ; Sun, WS	1
Kang, TH; Kim, SH; Kim, SU; Lee, JH; Moon, JS; Park, KD	1
Chi, ZL; Cui, HS; Hayasaka, S; Hayasaka, Y; Zhang, XY; Zheng, LS	1
Akao, T; Hattori, M; Nakamura, N; Zuo, F	1
Barthwal, R; Chauhan, L; Thankachan, PP; Tripathi, AN	1
Ma, L; Yang, XW	1
Apornpisarn, T; Nimgirawath, S; Taechowisan, T; Udomputtimekakul, P; Wanbanjob, A	1
Jha, RN; Pandey, MB; Singh, AK; Singh, S; Singh, VP	1
Deng, HB; Jiang, JD; Kong, WJ; Li, Y; Li, YH; Ren, G; Song, DQ; Wang, YM; Wang, YX; Yang, P; You, XF	1
Dunnick, JK; Kissling, GE; Nyska, A; Peckham, J; Sanders, JM; Singh, B	1
Jiang, JD; Kong, WJ; Li, Y; Li, YH; Li, ZR; Ren, G; Song, DQ; Wang, YM; Wang, YX; Yang, P; Yi, H	1
Chen, JX; Chen, M; Chen, MZ; Chen, WH; Jiang, ZH; Lin, WE; Lin, YL; Zhou, CQ	1
Basu, A; Jaisankar, P; Suresh Kumar, G	1
Chen, SN; Feng, R; Fu, J; He, CY; He, WY; Huang, M; Jiang, JD; Ma, C; Ma, JY; Shou, JW; Tan, XS; Wang, Y; Zhao, ZX	1
Chen, WJ; Feng, R; Fu, J; He, CY; He, WY; Huang, M; Jiang, JD; Ma, C; Ma, JY; Shou, JW; Sun, YP; Tan, XS; Wang, Y	1
Bin, W; Cao, S; Kang, N; Qiu, F; Wang, Y; Xu, P; Yan, J; Zhou, Y	1
Di, DL; Liu, JX; Ma, YX; Zhong, M	1
Calvarese, C; Camborata, C; Colliva, C; Ianni, C; Lisotti, A; Mazzella, G; Neri, F; Roberti, M; Roda, A; Spinozzi, S	1
Hai, L; He, Y; Li, R; Wu, J; Wu, Y	1
Dai, GL; Feng, CT; Ju, WZ; Ma, ST; Miao, CG; Song, Y; Yu, H; Zhang, XL; Zhou, GL	1
Bai, M; Jiang, H; Li, L; Song, F; Sun, S; Weng, Y; Zeng, S; Zhou, H; Zhou, S	1
Chavasiri, W; Pongkittiphan, V; Supabphol, R	1
Deng, M; Fan, M; Gao, Z; Hu, L; Lu, M; Ma, J; Wang, S; Wang, X; Ye, T	1
Fukuda, M; Hosoe, T; Ishikawa, K; Sato, F; Takeda, H; Wakana, D	1
Hosoe, T; Ishikawa, K; Sato, F; Takeda, H; Wakana, D	1
Aa, J; Fei, F; Feng, S; Fu, F; Geng, J; Guo, J; He, J; Liao, X; Sun, R; Wang, G; Wang, H; Wang, J; Xie, Y; Yang, N; Zhao, Y; Zhen, L; Zhu, X	1
Aa, JY; Chen, XL; Fei, F; Feng, SQ; Fu, FH; Ge, C; Geng, JL; Guo, JH; He, J; Sun, RB; Wang, GJ; Wang, HB; Yang, N; Yu, XY; Zhao, YQ; Zhen, L; Zhu, XX	1
Chen, C; Lian, W; Liu, S; Shi, L; Su, R; Wan, D; Wang, Y; Xu, N; Yang, H; Yao, W	1
Chandirasegaran, G; Elanchezhiyan, C; Ghosh, K; Sethupathy, S	1
Cao, S; Chai, L; Ding, L; Feng, X; Qiao, M; Qiu, F; Wang, K	1
Calabria, D; Caliceti, C; Franco, P; Porru, E; Roberti, M; Roda, A; Spinozzi, S	1
Chen, JP; Huang, YF; Li, HL; Qu, C; Su, ZR; Xu, LQ; Xu, YF; Yi, TG; Yu, XT; Zeng, HF; Zhang, XJ; Zheng, L	1
Bhuiya, S; Das, S; Fiorillo, G; Lombardi, P; Saha, U; Suresh Kumar, G; Yasmeen Khan, A	1
Hosoe, T; Sato, F; Takeda, H; Wakana, D; Yoshida, H	1
Choi, Y; Lin, H; Lin, L; Michniak-Kohn, B	1
Ding, L; Gao, Q; Guang, C; Qiu, F; Rao, J; Wang, K; Zhang, J; Zhang, T	1
Aa, J; Cao, B; Fei, F; Feng, D; Feng, S; Ge, C; Guo, GL; Huang, J; Kong, B; Lu, Z; Sun, R; Wang, G; Xie, Y; Yang, CS; Yang, N; Yu, X	1
Chepanova, AA; Gladkova, ED; Ilina, ES; Lavrik, OI; Luzina, OA; Reynisson, J; Salakhutdinov, NF; Volcho, KP; Zakharenko, AL	1
Ihmels, H; Wickhorst, PJ	1
Cheng, JY; Hu, XW; Li, DD; Man, RJ; Zhang, MH	1
Chang, JM; Chao, WY; Chen, SH; Chuang, HH; Kam, KH; Lee, YR; Li, YZ; Wu, JY; Yen, YP; Zhao, PW	1
Hu, XW; Huang, J; Liu, FL; Man, RJ; Yuchi, XX; Zhang, MH	1
Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q	1
Huang, J; Jiang, J; Kong, W; Lei, Y; Li, Y; Wang, C; Xie, J; Yuan, Z	1
Abuduaini, N; Cui, J; Feng, B; He, X; Huang, J; Huang, Y; Lu, W; Ma, H; Tang, L; Wang, W; Wang, Y; Zhang, Y	1
Boonyasuppayakorn, S; Chavasiri, W; Danova, A; Fujiki, R; Hengphasatporn, K; Nguyen, DV; Rungrotmongkol, T; Shigeta, Y; Suroengrit, A	1

Other Studies

50 other study(ies) available for berberrubine and berberine

Article	Year
Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8 Topics: Antiparasitic Agents; Berberine; Cells, Cultured; Inhibitory Concentration 50; Toxoplasma	2012
Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine. Biochemistry, 1998, Nov-17, Volume: 37, Issue:46 Topics: Berberine; Berberine Alkaloids; Catalysis; DNA Damage; DNA Topoisomerases, Type II; DNA, Superhelical; Enzyme Activation; Etoposide; Humans; Intercalating Agents; Peptide Mapping; Plants, Medicinal; Topoisomerase II Inhibitors	1998
Antimicrobial activity of 9-O-acyl- and 9-O-benzoyl-substituted berberrubines. Planta medica, 2000, Volume: 66, Issue:4 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Berberine; Fungi; Microbial Sensitivity Tests; Molecular Structure; Plants, Medicinal	2000
Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine. Molecular pharmacology, 2002, Volume: 61, Issue:4 Topics: Alkaloids; Antigens, Neoplasm; Antineoplastic Agents; Berberine; Colorectal Neoplasms; DNA Topoisomerases, Type II; DNA-Binding Proteins; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Half-Life; Humans; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured	2002
Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives. Planta medica, 2002, Volume: 68, Issue:3 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Berberine; Berberis; Fungi; Magnetic Resonance Spectroscopy; Plant Extracts; Quantitative Structure-Activity Relationship	2002
Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. Bioorganic & medicinal chemistry letters, 2006, Aug-01, Volume: 16, Issue:15 Topics: Antifungal Agents; Aspergillus; Berberine; Candida; Cryptococcus neoformans; Microbial Sensitivity Tests	2006
Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell line. Life sciences, 2006, Aug-01, Volume: 79, Issue:10 Topics: Berberine; Cell Line; Chemokine CCL2; Gene Expression; Humans; Immunohistochemistry; Interleukin-1; Interleukin-8; Molecular Structure; Pigment Epithelium of Eye; Protein Transport; RNA, Messenger; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2006
Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12 Topics: Animals; Bacteria; Berberine; Bile; Chromatography, Liquid; Germ-Free Life; Intestinal Absorption; Intestine, Small; Liver; Male; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2006
Quantum chemical and nuclear magnetic resonance spectral studies on molecular properties and electronic structure of berberine and berberrubine. Magnetic resonance in chemistry : MRC, 2007, Volume: 45, Issue:8 Topics: Antineoplastic Agents; Berberine; Carbon Isotopes; Computer Simulation; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Motion; Quantum Theory; Structure-Activity Relationship	2007
[Absorption of coptisine chloride and berberrubine across human intestinal epithelial by using human Caco-2 cell monolayers]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007, Volume: 32, Issue:23 Topics: Absorption; Berberine; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Corydalis; Epithelial Cells; Humans; Intestinal Mucosa; Plants, Medicinal	2007
Total syntheses of (+/-)-gusanlung a, (+/-)-gusanlung D and 8-oxyberberrubine and the uncertainty concerning the structures of (-)-gusanlung A, (-)-gusanlung D and 8-oxyberberrubine. Molecules (Basel, Switzerland), 2009, Feb-12, Volume: 14, Issue:2 Topics: Berberine; Candida albicans; Drugs, Chinese Herbal; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Staphylococcus aureus	2009
New alkaloids from Corydalis species. Natural product research, 2009, Volume: 23, Issue:3 Topics: Alkaloids; Berberine; Bicuculline; Corydalis; Heterocyclic Compounds, 4 or More Rings; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts	2009
Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. Bioorganic & medicinal chemistry, 2010, Sep-01, Volume: 18, Issue:17 Topics: Animals; Anticholesteremic Agents; Berberine; Biological Availability; Cholesterol; Hyperlipidemias; Male; Prodrugs; Rats; Rats, Sprague-Dawley	2010
Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle. Toxicologic pathology, 2011, Volume: 39, Issue:2 Topics: Animals; Berberine; Body Weight; Carcinogens; Female; Flavonolignans; Hydrastis; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Plant Preparations; Plant Roots; Rats; Rats, Inbred F344; Silybin; Silybum marianum; Silymarin; Topoisomerase Inhibitors; Toxicity Tests, Chronic	2011
Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. Journal of translational medicine, 2011, May-15, Volume: 9 Topics: AMP-Activated Protein Kinases; Animals; Berberine; Biotransformation; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Isoenzymes; Liver; Male; Metabolic Detoxication, Phase I; Rats; Rats, Wistar; Receptor, Insulin; Receptors, LDL	2011
Synthesis, characterization and potent DNA-cleaving activity of copper(II)-complexed berberine carboxylate. Bioorganic & medicinal chemistry letters, 2012, Dec-01, Volume: 22, Issue:23 Topics: Berberine; Carboxylic Acids; Coordination Complexes; Copper; DNA; DNA Cleavage; Kinetics	2012
Binding of the 9-O-N-aryl/arylalkyl amino carbonyl methyl substituted berberine analogs to tRNA(phe.). PloS one, 2013, Volume: 8, Issue:3 Topics: Berberine; Binding Sites; Biophysical Phenomena; Nucleic Acid Conformation; RNA Stability; RNA, Fungal; RNA, Transfer, Phe; Thermodynamics	2013
Excretion of berberine and its metabolites in oral administration in rats. Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:11 Topics: Administration, Oral; Animals; Berberine; Bile; Chromatography, High Pressure Liquid; Feces; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2013
Tissue distribution of berberine and its metabolites after oral administration in rats. PloS one, 2013, Volume: 8, Issue:10 Topics: Administration, Oral; Animals; Area Under Curve; Berberine; Chromatography, Liquid; Humans; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution	2013
Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells. Fitoterapia, 2014, Volume: 92 Topics: Berberine; Berberine Alkaloids; Berberis; Carcinoma, Hepatocellular; Coptis; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hypolipidemic Agents; Lipid Metabolism; Lipoproteins, LDL; Liver Neoplasms; Plant Extracts; Receptors, LDL; RNA, Messenger; Up-Regulation	2014
A new quaternary protoberberine alkaloid isolated from Dicranostigma leptopodum (Maxim) Fedde. Natural product research, 2014, Volume: 28, Issue:8 Topics: Berberine; Berberine Alkaloids; Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Papaveraceae	2014
Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. Journal of natural products, 2014, Apr-25, Volume: 77, Issue:4 Topics: Administration, Oral; Adult; Alkaloids; Berberine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Female; Humans; Male; Molecular Structure	2014
Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics. Bioorganic & medicinal chemistry letters, 2014, Apr-01, Volume: 24, Issue:7 Topics: 3T3-L1 Cells; Adipocytes; Animals; Berberine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; Insulin Resistance; Mice; Molecular Structure; Muscle Fibers, Skeletal; Rats; Structure-Activity Relationship	2014
In silico target fishing for the potential bioactive components contained in Huanglian Jiedu Tang (HLJDD) and elucidating molecular mechanisms for the treatment of sepsis. Chinese journal of natural medicines, 2015, Volume: 13, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Berberine; Dinoprostone; Drugs, Chinese Herbal; Humans; KB Cells; Platelet Membrane Glycoproteins; Protein Transport; Receptors, G-Protein-Coupled; Receptors, Thromboxane A2, Prostaglandin H2; Sepsis; Tetradecanoylphorbol Acetate	2015
Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3. Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Berberine; Berberine Alkaloids; Cells, Cultured; Chromatography, Liquid; Dogs; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Octamer Transcription Factor-3; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymorphism, Genetic; Tandem Mass Spectrometry	2016
Antioxidant Effect of Berberine and its Phenolic Derivatives Against Human Fibrosarcoma Cells. Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:13 Topics: Antioxidants; Apoptosis; Berberine; Biomarkers; Biphenyl Compounds; Catalase; Cell Proliferation; Cells, Cultured; Fibrosarcoma; Gene Expression Profiling; Humans; Oxidation-Reduction; Phenols; Picrates; Plant Extracts; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase	2015
Pharmacokinetics in rats and tissue distribution in mouse of berberrubine by UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis, 2015, Nov-10, Volume: 115 Topics: Administration, Intravenous; Administration, Oral; Animals; Berberine; Biological Availability; Calibration; Chromatography, Liquid; Drug Stability; Limit of Detection; Linear Models; Male; Mice; Models, Biological; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution	2015
11-Hydroxylation of Protoberberine by the Novel Berberine-Utilizing Aerobic Bacterium Sphingobium sp. Strain BD3100. Journal of natural products, 2015, Dec-24, Volume: 78, Issue:12 Topics: Benzoflavones; Berberine; Berberine Alkaloids; Cytochrome P-450 Enzyme Inhibitors; Hydroxylation; Japan; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Sphingomonadaceae	2015
Isolation and identification of berberine and berberrubine metabolites by berberine-utilizing bacterium Rhodococcus sp. strain BD7100. Bioscience, biotechnology, and biochemistry, 2016, Volume: 80, Issue:5 Topics: Berberine; Berberine Alkaloids; Biotransformation; Culture Media; Phenylacetates; Rhodococcus	2016
High fat diet aggravates the nephrotoxicity of berberrubine by influencing on its pharmacokinetic profile. Environmental toxicology and pharmacology, 2016, Volume: 46 Topics: Animals; Anti-Obesity Agents; Berberine; Cell Line; Cell Survival; Diet, High-Fat; Humans; Kidney; Kidney Function Tests; Lipids; Male; Mice, Inbred C57BL; Renal Insufficiency	2016
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine. Acta pharmacologica Sinica, 2017, Volume: 38, Issue:3 Topics: Animals; Berberine; Glucuronides; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Mice, Inbred C57BL; Rats, Sprague-Dawley	2017
High-throughput screening of triplex DNA binders from complicated samples by 96-well pate format in conjunction with peak area-fading UHPLC-Orbitrap MS. The Analyst, 2017, Feb-14, Volume: 142, Issue:4 Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; DNA; High-Throughput Screening Assays; Mass Spectrometry; Phellodendron; Reproducibility of Results	2017
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95 Topics: Animals; Antioxidants; Apoptosis; Berberine; Blood Glucose; Diabetes Mellitus, Experimental; Inflammation; Male; Oxidative Stress; Pancreas; Rats; Rats, Wistar; Streptozocin	2017
Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Fitoterapia, 2018, Volume: 124 Topics: Administration, Oral; Animals; Berberine; Bile; Chromatography, High Pressure Liquid; Feces; Male; Mass Spectrometry; Metabolome; Plasma; Rats; Rats, Sprague-Dawley	2018
Combined analytical approaches to define biodistribution and biological activity of semi-synthetic berberrubine, the active metabolite of natural berberine. Analytical and bioanalytical chemistry, 2018, Volume: 410, Issue:15 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Berberine; Berberis; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Male; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution; Xanthine Oxidase	2018
Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. PloS one, 2018, Volume: 13, Issue:3 Topics: Animals; Berberine; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Peroxidase; Tight Junction Proteins; Tight Junctions	2018
Targeting human telomeric DNA quadruplex with novel berberrubine derivatives: insights from spectroscopic and docking studies. Journal of biomolecular structure & dynamics, 2019, Volume: 37, Issue:6 Topics: Algorithms; Berberine; Calorimetry; Circular Dichroism; G-Quadruplexes; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Spectrum Analysis; Structure-Activity Relationship; Telomere	2019
Identification of a multi-component berberine 11-hydroxylase from Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:6 Topics: Bacterial Proteins; Berberine; Berberine Alkaloids; Burkholderia; Escherichia coli; Ferredoxins; Genome, Bacterial; Hydroxylation; Microorganisms, Genetically-Modified; Mixed Function Oxygenases; Oxidoreductases; Phylogeny; Recombinant Proteins	2020
Development and in-vitro evaluation of co-loaded berberine chloride and evodiamine ethosomes for treatment of melanoma. International journal of pharmaceutics, 2020, May-15, Volume: 581 Topics: Animals; Berberine; Drug Delivery Systems; Drug Development; Female; Humans; Liposomes; Melanoma, Experimental; Mice; Middle Aged; Plant Extracts; Quinazolines; Skin Absorption	2020
Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity. Drug design, development and therapy, 2020, Volume: 14 Topics: Activation, Metabolic; Animals; Berberine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2020
The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis. Drug metabolism and disposition: the biological fate of chemicals, 2021, Volume: 49, Issue:3 Topics: Animals; Berberine; Blood Glucose; Diet, High-Fat; Gluconeogenesis; Hypoglycemic Agents; Ileum; Liver; Male; Mice; Mice, Inbred C57BL; Protein Structure, Secondary; Receptors, Cytoplasmic and Nuclear; Signal Transduction	2021
Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. Molecules (Basel, Switzerland), 2021, Mar-30, Volume: 26, Issue:7 Topics: Antineoplastic Agents; Berberine; Drug Design; HeLa Cells; Humans; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship	2021
Berberrubine Phosphate: A Selective Fluorescent Probe for Quadruplex DNA. Molecules (Basel, Switzerland), 2021, Apr-28, Volume: 26, Issue:9 Topics: Berberine; DNA; Fluorescent Dyes; Fluorometry; G-Quadruplexes; Molecular Structure; Nucleic Acid Denaturation; Phosphates; Spectrum Analysis; Structure-Activity Relationship; Temperature	2021
A berberrubine-derived fluorescent probe for hydrazine and its practical application in water and food samples. Analytica chimica acta, 2021, Aug-08, Volume: 1172 Topics: Berberine; Fluorescent Dyes; Hydrazines; Water	2021
9-O-Terpenyl-Substituted Berberrubine Derivatives Suppress Tumor Migration and Increase Anti-Human Non-Small-Cell Lung Cancer Activity. International journal of molecular sciences, 2021, Sep-13, Volume: 22, Issue:18 Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Berberine; Bromides; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Humans; Terpenes	2021
A fluorescent probe derived from Berberrubine for detecting hydrogen polysulfide in food samples. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2022, Feb-15, Volume: 267, Issue:Pt 1 Topics: Berberine; Fluorescent Dyes; Hydrogen; Sulfides	2022
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. European journal of pharmacology, 2021, Dec-05, Volume: 912 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Cytokines; Disease Models, Animal; Glucose Transport Proteins, Facilitative; Hyperuricemia; Hypoxanthine; Janus Kinase 2; Kidney Diseases; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Protective Agents; Signal Transduction; STAT3 Transcription Factor; Uric Acid; Xanthine Oxidase	2021
Integrated metabolomics and molecular docking reveal berberrubine inhibits thrombosis by regulating the vitamin K catalytic cycle in mice. European journal of pharmacology, 2023, Jan-05, Volume: 938 Topics: Animals; Berberine; Carrageenan; Fibrinolytic Agents; GTPase-Activating Proteins; Mice; Molecular Docking Simulation; Thrombosis; Vitamin K; Vitamin K Epoxide Reductases	2023
Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer. Biochemical pharmacology, 2023, Volume: 218 Topics: Animals; Berberine; Cell Line; Colorectal Neoplasms; Humans; IMP Dehydrogenase; Mice; Protein Isoforms	2023
Structure-yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates. Scientific reports, 2023, 11-01, Volume: 13, Issue:1 Topics: alpha-Glucosidases; Benzoates; Berberine; Glycoside Hydrolase Inhibitors; Kinetics; Molecular Docking Simulation; Molecular Structure; Saccharomyces cerevisiae; Structure-Activity Relationship	2023