berberine and stepholidine

berberine has been researched along with stepholidine in 105 studies

Research

Studies (105)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (15.24)	18.7374
1990's	49 (46.67)	18.2507
2000's	24 (22.86)	29.6817
2010's	15 (14.29)	24.3611
2020's	1 (0.95)	2.80

Authors

Authors	Studies
Brochmann-Hanssen, E; Richter, WJ	1
Jin, GZ; Sun, BC	2
Chen, LJ; Guo, X; Jin, GZ; Wang, QM	1
Buda, M; Chen, LJ; Guo, X; Jin, GZ	1
Huang, KX; Jin, GZ; Sun, BC	2
Hu, G; Hu, Y; Jin, GZ	2
Huang, KX; Jin, GZ	1
Li, DX; Wang, W; Xuan, B	1
He, YF; Jin, GZ; Lu, YQ; Shen, DL; Sun, Z; Yang, ZC; Zhang, ZD	1
Jiang, MH; Jin, GZ; Lin, C; Miao, YS; Zhang, AZ	1
Wei, D	1
Gonon, FG; Huang, KX; Jin, GZ; Sun, BC	1
Jin, GZ; Yang, L; Zhang, X; Zhang, ZD; Zhou, CM	1
Chen, BD; Jin, GZ; Sun, Z; Xia, XP	1
Gu, TH; Zhang, ZY; Zhou, KR	1
Cao, XD; Jiang, JW; Wu, G; Wu, GC	1
Chen, Y; Han, YR; Jin, GZ; Xu, SX; Yu, LP	1
Le, W	1
Chen, Y; Jin, GZ; Sun, Z; Xiong, ZL	1
Jin, GZ; Shi, WX; Wang, XL	1
Jin, GZ	2
Chen, LF; Gao, JZ; Wang, FC; Yang, CR	1
Chen, LF; Gao, JZ; Wang, FC	1
Bian, CF; Chen, Y; Duan, SM; Jin, GZ; Qin, W; Xing, SH; Yu, YM	1
Bian, CF; Chen, Y; Ding, YL; Jiang, FY; Jin, GZ; Sun, Z; Xu, SX; Yu, LP; Zhang, YR; Zhang, ZD	1
Cai, N	1
Chen, Y; Jin, GZ; Lin, GD; Xuan, JC	1
Jin, GZ; Xiao, XS; Yang, FZ; Zhu, XM	1
Le, WD; Wang, WJ; Zhou, XD	1
Liu, GQ; Xie, L; Yuan, HN	1
Chen, Y; Jin, GZ; Shi, WX	1
Hu, G; Jin, GZ	1
Han, Q; Jiang, MH; Jin, GZ; Miao, YS; Yang, S	1
Li, DX; Xuan, B; Zhou, J	1
Li, XT; Wang, JX; Wang, YL; Yang, SJ	1
He, YF; Huang, KX; Jin, GZ	1
Dong, ZJ; Huang, HY; Jin, GZ	1
Chen, KX; Ji, RY; Jiang, HL; Jin, GZ; Tang, Y	1
Jin, GZ; Zhang, XX	1
Jin, GZ; Sun, BC; Zhang, XX	1
Jin, GZ; Wu, JH	1
Chen, LJ; Dong, ZJ; Guo, X; Han, YF; Jin, GZ	1
Chen, LJ; Creese, I; Dong, ZJ; Jin, GZ	1
Jin, GZ; Liu, J; Zou, LL	1
Ding, YM; Guo, X; Hu, JY; Jin, GZ	1
Jin, GZ; Zhang, XX; Zhu, ZT	1
Shi, L; Wang, YX; Xue, AQ	1
Chen, Y; Jin, GZ; Song, YY; Zou, LL	1
Chen, LJ; Han, ZF; Jin, GZ; Qu, YS; Wang, YM; You, CL	1
Cai, ST; Jin, GZ; Zou, LL	1
Han, QD; Jin, GZ; Lu, ZZ; Wei, X	1
Lei, S; Mulvany, MJ; Orensanz, LM; Simonsen, U	1
Hu, G; Jin, GZ; Wu, YM	1
Guo, X; Jin, GZ; Jin, J; Liu, J; Wang, BC; Zou, LL	1
Hu, JY; Jin, GZ	1
Lin, D; Wang, J; Zhao, L	1
Fu, Y; Hu, GY; Jin, GZ; Zhu, ZT	2
Chen, YT; Ding, YM; Jin, GZ; Sun, YF; Tang, FM; Wang, R; Zhang, GY	1
Fu, Y; Hu, GY; Jin, GZ; Liu, J; Zhang, XX	1
Chen, LJ; Jin, GZ; Jin, XL; Shao, Y; Wang, MJ	1
Fu, Y; Jin, GZ; Wu, WR; Zhu, ZT	1
Ding, YM; Fu, Y; Jin, GZ; Tang, FM; Yu, LP; Zhang, GY	1
Fu, Y; Jin, GZ; Zhu, ZT	1
Guo, X; Jin, GZ; Liu, J; Wang, BC	1
Duan, G; Guo, J; Huang, J	1
Guo, W; Jin, G; Zhang, W; Zhao, R; Zhi, J	1
Guo, H; Jin, GZ; Xing, L; Yu, Y; Zhou, J	1
Li, XY; Liu, J; Zhu, XZ	1
Chen, YT; Jin, GZ; Jin, XL; Mo, YQ; Shi, WX	1
Xiang, G; Zhang, L; Zhou, R	1
Ellenbroek, BA; Jin, GZ; Zhang, XX	1
Dai, Z; Jin, G; Kang, L; Ma, L; Pan, L; Sun, J; Wang, W; Yu, R; Zhou, Y	1
Baker, GB; Kapur, S; MacKenzie, EM; Mamo, D; Natesan, S; Odontiadis, J	1
Gao, M; Jin, GZ; Liu, CL; Yang, S; Zhen, XC	1
Briggs, JM; Chen, K; Cheng, J; Fu, W; Jiang, H; Jin, G; Luo, X; Shen, J; Yu, K; Zhu, W	1
Gu, WH; Jin, GZ; Shi, WX; Yang, S; Zhen, XC	1
Chu, H; Friedman, E; Jin, G; Zhen, X	1
Guo, Y; Jin, GZ; Mo, J; Shen, JS; Yang, YS; Zhen, X	1
Baker, GB; Barlow, KB; George, SR; Kapur, S; Mamo, D; Natesan, S; Nobrega, JN; Odontiadis, J; Reckless, GE	1
Jin, GZ; Mo, J; Sun, PH; Yu, LP; Zhang, H; Zhen, X	1
Chen, JJ; Jiang, ZY; Ma, YB; Wang, EJ; Zhang, XM	1
Huang, ZL; Qiu, MH; Qu, WM; Urade, Y; Xu, XH; Yan, MM	1
Cai, W; Chen, X; Cheng, J; Guo, Y; Jin, G; Yang, Y; Zhang, H; Zhen, X	1
Dai, J; Du, F; Hu, Z; Jin, G; Li, C; Liu, F; Niu, W; Sun, Y; Wang, F	1
Cheng, JJ; Yang, YS	1
Chu, HY; Gao, M; Jin, GZ; Wu, J; Zhang, ZJ; Zhen, XC	1
Du, P; Fu, W; Li, B; Li, W; Yu, KQ	1
Chen, K; Gao, B; Guo, L; Jiang, H; Li, Z; Liu, H; Qian, W; Sun, H; Yang, H; Zhen, X; Zhou, S; Zhou, Y; Zhu, L	1
Chen, L; Gan, Y; Jin, G; Li, C; Ma, B; Ru, Q; Tian, X; Wang, D; Yue, K	2
Chun, LS; Conroy, JL; Doyle, TB; Free, RB; Meade, JA; Miller, NR; Moritz, AE; Sibley, DR; Watts, VJ	1
Gao, C; Hao, JR; Hu, R; Lei, L; Li, XY; Shi, XD; Sun, K; Sun, N; Yao, B; Zhang, X	1
Chen, J; Du, P; Fu, W; Li, W; Xu, L; Yuan, C; Zhang, L; Zhen, X	1
Alberts, IL; Gadhiya, S; Harding, WW; Kurtzman, T; Madapa, S; Ramsey, S; Reith, M	1
Guo, F; Jin, GZ; Li, Y; Lin, R; Liu, ZQ; Ma, Y; Shen, FY; Song, Y; Zhang, B	1
Caro, Y; Hicks, C; Huang, P; Lee, DY; Liu-Chen, LY; Nayak, SU; Ramos, L; Rawls, SM; Reitz, AB; Smith, GR	1
Gadhiya, S; Harding, W; Manuszak, M; Ranaldi, R	1
Chen, L; Gong, X; Li, C; Ru, Q; Si, Y; Xiao, H; Xiong, Q; Zhou, M	1
Cordone, P; Gadhiya, S; Gallicchio, E; Harding, WW; Kurtzman, T; Pal, RK; Ramsey, S; Wickstrom, L	1
Barrera, E; Bennett, A; Harding, W; Namballa, H; Ranaldi, R	1

Reviews

5 review(s) available for berberine and stepholidine

Article	Year
[Progress in studies of the pharmacology of l-tetrahydropalmatine and l-stepholidine]. Yao xue xue bao = Acta pharmaceutica Sinica, 1987, Volume: 22, Issue:6 Topics: Alkaloids; Antipsychotic Agents; Berberine; Berberine Alkaloids; Receptors, Dopamine	1987
(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions. Trends in pharmacological sciences, 2002, Volume: 23, Issue:1 Topics: Animals; Antipsychotic Agents; Basal Ganglia; Berberine; Clinical Trials as Topic; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Humans; Neurons; Nucleus Accumbens; Prefrontal Cortex; Receptors, Dopamine D1; Schizophrenia; Synaptic Transmission; Ventral Tegmental Area	2002
Recent pharmacological studies on natural products in China. European journal of pharmacology, 2004, Oct-01, Volume: 500, Issue:1-3 Topics: Alkaloids; Animals; Benzofurans; Berberine; China; Cholinesterase Inhibitors; Diterpenes; Dopamine Agonists; Dopamine Antagonists; Drugs, Chinese Herbal; Epoxy Compounds; Ginkgo biloba; Humans; Immunosuppressive Agents; Lactams; Lignans; Neuroprotective Agents; Phenanthrenes; Rutaceae; Sesquiterpenes	2004
Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction. Cellular and molecular neurobiology, 2008, Volume: 28, Issue:4 Topics: Analgesics; Animals; Berberine; Berberine Alkaloids; Dopamine Antagonists; Humans; Models, Biological; Pain; Receptors, Dopamine; Substance-Related Disorders	2008
Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications. Current medicinal chemistry, 2007, Volume: 14, Issue:28 Topics: Berberine; Berberine Alkaloids; Dopamine; Humans; Mental Disorders; Parkinson Disease; Receptors, Dopamine	2007

Trials

2 trial(s) available for berberine and stepholidine

Article	Year
[Clinical study on the treatment of dyskinesia by L-stepholidine]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1989, Volume: 22, Issue:6 Topics: Aged; Berberine; Berberine Alkaloids; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Movement Disorders; Multicenter Studies as Topic; Tourette Syndrome	1989
[A controlled study on the treatment of tardive dyskinesia using 1-stepholidine]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1988, Volume: 21, Issue:5 Topics: Adult; Aged; Berberine; Berberine Alkaloids; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Stereoisomerism	1988

Other Studies

98 other study(ies) available for berberine and stepholidine

Article	Year
Opium alkaloids XV: isolation of stepholidine. Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:6 Topics: Berberine; Berberine Alkaloids; Chromatography, Thin Layer; Mass Spectrometry	1975
Effects of (-)-stepholidine on firing activity of dopamine neurons in ventral tegmental area of rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:5 Topics: Animals; Apomorphine; Berberine; Electrophysiology; Haloperidol; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tegmentum Mesencephali	1992
[Feed-back regulation of presynaptic D2 receptors blockaded by l-stepholidine and l-tetrahydropalmatine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:5 Topics: Alkaloids; Animals; Apomorphine; Berberine; Berberine Alkaloids; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Levodopa; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism	1992
Effects of l-stepholidine on tyrosine hydroxylase activity in rat corpus striatum. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Berberine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tyrosine 3-Monooxygenase	1992
Dual actions of (-)-stepholidine on dopamine receptor subtypes after substantia nigra lesion. Neurochemistry international, 1992, Volume: 20 Suppl Topics: Animals; Apomorphine; Berberine; Dopamine Antagonists; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereoisomerism; Stereotyped Behavior; Substantia Nigra; Tetrahydronaphthalenes; Thiophenes	1992
Effects of l-stepholidine on synaptosomal Ca(2+)-ATPase and subcellular calmodulin in rat striatum. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:4 Topics: Animals; Berberine; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Corpus Striatum; Dose-Response Relationship, Drug; Female; Haloperidol; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synaptosomes	1992
The antagonistic effects of tetrahydroprotoberberines on dopamine receptors: electrophysiological studies. Science in China. Series B, Chemistry, life sciences & earth sciences, 1992, Volume: 35, Issue:6 Topics: Alkaloids; Animals; Apomorphine; Berberine; Berberine Alkaloids; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra	1992
Antagonism of l-stepholidine on D2 receptor-mediated inhibition of synaptosomal adenylate cyclase in rat corpus striatum. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:2 Topics: Adenylyl Cyclases; Animals; Berberine; Corpus Striatum; Dopamine Antagonists; Female; GTP Phosphohydrolases; Rats; Rats, Inbred Strains; Receptors, Dopamine; Synaptosomes	1992
[Protective effects of tetrahydroprotoberberines on experimental myocardial infarction in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:2 Topics: Alkaloids; Animals; Aspartate Aminotransferases; Berberine; Berberine Alkaloids; Creatine Kinase; Female; Hemodynamics; Male; Myocardial Infarction; Rats; Rats, Inbred Strains	1992
(-)-stepholidine: a dopamine receptor antagonist shows agonistic effect on rotational behavior in 6-hydroxydopamine-lesioned rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:1 Topics: Animals; Behavior, Animal; Berberine; Dopamine Antagonists; Dose-Response Relationship, Drug; Hydroxydopamines; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation	1992
[Effect of (-)-stepholidine on blood pressure and alpha-adrenoceptor agonists-, KCl- and CaCl2-evoked contractions of aortic strips]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:6 Topics: Animals; Antihypertensive Agents; Aorta; Berberine; Blood Pressure; Calcium Chloride; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha	1991
[Effects of l-stepholidine on isolated rabbit basilar artery, mesenteric artery, and thoracic aorta]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:3 Topics: Animals; Aorta, Thoracic; Basilar Artery; Berberine; Dose-Response Relationship, Drug; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Stereoisomerism	1991
[Different effects on dopamine receptors D1 and D2 following long-term usage of L-dopa]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1991, Volume: 24, Issue:2 Topics: Animals; Behavior, Animal; Berberine; Corpus Striatum; Levodopa; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Substantia Nigra	1991
[Effects of tetrahydroprotoberberines on dopamine release and 3,4-dihydroxyphenylacetic acid level in corpus striatum measured by in vivo voltammetry]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Animals; Berberine; Berberine Alkaloids; Calcium Channel Blockers; Caudate Nucleus; Corpus Striatum; Dopamine; Male; Microelectrodes; Polarography; Rats; Stereoisomerism	1991
Pharmacokinetics and autoradiography of [3H] or [14C]stepholidine. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:4 Topics: Animals; Autoradiography; Berberine; Carbon Radioisotopes; Female; Male; Mice; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium	1990
[Ocular hypotensive action of l-stepholidine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:2 Topics: Animals; Aqueous Humor; Berberine; Carbonic Anhydrases; Intraocular Pressure; Mice; Pilocarpine; Pupil; Rabbits; Stereoisomerism; Timolol	1990
[Hypotensive action of l-stepholidine in relation of dopamine receptors]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:5 Topics: Animals; Antihypertensive Agents; Berberine; Blood Pressure; Epinephrine; Hypertension, Renovascular; Male; Norepinephrine; Prolactin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Dopamine; Stereoisomerism	1990
[Potentiation of electroacupuncture analgesia by l-tetrahydropalmatine and its analogues in rabbits]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:2 Topics: Acupuncture Analgesia; Alkaloids; Animals; Berberine; Berberine Alkaloids; Electroacupuncture; Female; Male; Pain; Rabbits; Sensory Thresholds	1990
Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1989, Volume: 10, Issue:2 Topics: Adenylyl Cyclases; Alkaloids; Animals; Berberine; Berberine Alkaloids; Brain; Cattle; Corpus Striatum; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereoisomerism	1989
[Influence of l-stepholidine on blood pressure and its relation to alpha-adrenoceptors]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:6 Topics: Animals; Berberine; Berberine Alkaloids; Blood Pressure; Dogs; Rats; Receptors, Adrenergic, alpha; Reserpine; Stereoisomerism; Yohimbine	1987
Tetrahydroprotoberberine--a new chemical type of antagonist of dopamine receptors. Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences, 1986, Volume: 29, Issue:5 Topics: Alkaloids; Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; Corpus Striatum; Haloperidol; Rats; Receptors, Dopamine; Scopolamine; Substantia Nigra	1986
[Analgesic, sedative and antispastic effects of l-stepholidine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1985, Volume: 6, Issue:3 Topics: Analgesics; Animals; Berberine; Berberine Alkaloids; Female; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Parasympatholytics; Rabbits	1985
[Analgesic and antipyretic effects of l-stepholidine without addiction]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Berberine Alkaloids; Male; Mice; Rabbits; Substance-Related Disorders	1986
[Interaction of analgesics and l-stepholidine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:5 Topics: Analgesics; Animals; Berberine; Berberine Alkaloids; Dogs; Drug Synergism; Electroencephalography; Etorphine; Female; Heart Rate; Male; Meperidine; Mice; Pain; Rabbits; Respiration; Sensory Thresholds	1986
[Effects of l-stepholidine on the central nervous and cardiovascular systems]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:6 Topics: Analgesics; Animals; Berberine; Berberine Alkaloids; Blood Pressure; Catalepsy; Dogs; Female; Male; Mice; Rats; Receptors, Dopamine; Stereotyped Behavior; Vascular Resistance	1986
[Relevance of stereo and quantum chemistry of four tetrahydroprotoberberines to their effects on dopamine receptors]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:3 Topics: Alkaloids; Animals; Berberine; Berberine Alkaloids; Cattle; Molecular Conformation; Quantum Theory; Rats; Receptors, Dopamine; Stereoisomerism; Structure-Activity Relationship	1988
[Effects of l-stepholidine on open-field behavior and discrimination learning in mice]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:5 Topics: Animals; Apomorphine; Behavior, Animal; Berberine; Berberine Alkaloids; Discrimination Learning; Female; Haloperidol; Male; Mice; Receptors, Dopamine; Stereoisomerism	1987
[1-SPD, a new dopamine receptors blocker, in treating vascular headache]. Zhonghua nei ke za zhi, 1987, Volume: 26, Issue:12 Topics: Adolescent; Adult; Berberine; Berberine Alkaloids; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Stereoisomerism; Vascular Headaches	1987
[Effect of L-stepholidine on monoamine metabolism in the rat brain]. Yao xue xue bao = Acta pharmaceutica Sinica, 1986, Volume: 21, Issue:5 Topics: Animals; Berberine; Berberine Alkaloids; Biogenic Amines; Brain; Corpus Striatum; Female; Limbic System; Male; Rats	1986
[Effect of l-stepholidine on rotational behavior in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1984, Volume: 5, Issue:4 Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Berberine; Berberine Alkaloids; Dopamine Antagonists; Haloperidol; Male; Motor Activity; Rats; Receptors, Dopamine; Rotation	1984
Neuropharmacological effects of (-)-stepholidine and its analogues on brain dopaminergic system. Advances in experimental medicine and biology, 1995, Volume: 363 Topics: Animals; Berberine; Brain; Dopamine Antagonists; Male; Rats	1995
(-)-Stepholidine antagonizes the inhibition by D2 receptor agonists on synaptosomal tyrosine hydroylase in rat corpus striatum. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:4 Topics: Animals; Berberine; Corpus Striatum; Dopamine Antagonists; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Synaptosomes; Tyrosine 3-Monooxygenase	1995
[Relation between cerebral dopaminergic system and pharmacological action of 1-tetrahydroprotoberbines]. Sheng li ke xue jin zhan [Progress in physiology], 1993, Volume: 24, Issue:2 Topics: Animals; Berberine; Berberine Alkaloids; Dopamine Antagonists; Drugs, Chinese Herbal; Stereoisomerism; Structure-Activity Relationship	1993
Effects of (-)-stepholidine and tetrahydroberberine on high potassium-evoked contraction and calcium influx in rat artery. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:3 Topics: Animals; Aorta, Thoracic; Berberine; Calcium Channel Blockers; Calcium-Transporting ATPases; Dopamine Antagonists; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Verapamil	1993
Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Berberine; Berberine Alkaloids; In Vitro Techniques; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Verapamil; Xanthine Oxidase	1993
[Effects of tetrahydroprotoberberines on cytosolic free calcium in cultured rat single myocardial cells]. Yao xue xue bao = Acta pharmaceutica Sinica, 1995, Volume: 30, Issue:8 Topics: Animals; Animals, Newborn; Berberine; Berberine Alkaloids; Biological Transport, Active; Calcium; Calcium Channel Blockers; Cells, Cultured; Myocardium; Rats; Rats, Sprague-Dawley; Verapamil	1995
[Effect of (-) stepholidine on dopamine turnover in various brain regions]. Sheng li xue bao : [Acta physiologica Sinica], 1995, Volume: 47, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Berberine; Brain; Dopamine; Dopamine Antagonists; Hypothalamo-Hypophyseal System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereoisomerism	1995
Augmentation of dopamine release by (-)-stepholidine from rabbit and rat caudate slices. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:6 Topics: Animals; Berberine; Caudate Nucleus; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quinpirole; Rabbits; Rats; Receptors, Dopamine D2	1995
Molecular modeling of interactions between tetrahydroprotoberberines and dopamine receptors. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:1 Topics: Amino Acid Sequence; Bacteriorhodopsins; Berberine; Berberine Alkaloids; Binding Sites; Dopamine Antagonists; Drug Interactions; Models, Chemical; Molecular Sequence Data; Receptors, Dopamine D1; Receptors, Dopamine D2	1996
(-)-stepholidine vs 12-chloroscoulerine enantiomers on firing activity of substantia nigral dopamine neurons. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:1 Topics: Animals; Apomorphine; Berberine; Berberine Alkaloids; Dopamine Antagonists; Electrophysiology; Male; Neurons; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substantia Nigra	1996
(-)-Stepholidine acts as a D1 partial agonist on firing activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine-lesioned rats. Life sciences, 1996, Volume: 59, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Berberine; Dopamine Agonists; Electrophysiology; Haloperidol; Male; Membrane Potentials; Microelectrodes; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Substantia Nigra	1996
[Effects of (-) SPD and (-) THP on the firing of noradrenergic neurons in locus coeruleus]. Sheng li xue bao : [Acta physiologica Sinica], 1995, Volume: 47, Issue:6 Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Berberine; Berberine Alkaloids; Electrophysiology; Locus Coeruleus; Male; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha	1995
Dual actions of (-)-stepholidine on the dopamine receptor-mediated adenylate cyclase activity in rat corpus striatum. Life sciences, 1997, Volume: 61, Issue:4 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Benzazepines; Berberine; Butaclamol; Colforsin; Corpus Striatum; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Synaptosomes	1997
GTP regulation of (-)-stepholidine binding to R(H) of D1 dopamine receptors in calf striatum. Biochemical pharmacology, 1997, Jul-15, Volume: 54, Issue:2 Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Berberine; Binding, Competitive; Cattle; Corpus Striatum; Guanosine Triphosphate; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation; Spiperone	1997
Involvement of receptor reserve in D1 agonistic action of (-)-stepholidine in lesioned rats. Biochemical pharmacology, 1997, Jul-15, Volume: 54, Issue:2 Topics: Adenylyl Cyclases; Animals; Apomorphine; Berberine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Oxidopamine; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation	1997
Involvement of dopamine D1 and D2 receptors in Fos immunoreactivity induced by stepholidine in both intact and denervated striatum of lesioned rats. Life sciences, 1998, Volume: 62, Issue:25 Topics: Animals; Berberine; Corpus Striatum; Denervation; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Horseradish Peroxidase; Immunohistochemistry; Male; Nerve Tissue Proteins; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reference Values	1998
Comparison of (-)-stepholidine and D1 or D2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats. Life sciences, 1998, Volume: 63, Issue:7 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Berberine; Calcium Channel Blockers; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Globus Pallidus; Male; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2	1998
[Relaxing effects of l-stepholidine on rat resistance arteries]. Yao xue xue bao = Acta pharmaceutica Sinica, 1996, Volume: 31, Issue:7 Topics: Animals; Berberine; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Vascular Resistance	1996
Effect of (-)-stepholidine on serum prolactin level of female rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:4 Topics: Animals; Berberine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Pergolide; Prolactin; Rats; Rats, Sprague-Dawley	1996
[Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:4 Topics: Animals; Berberine; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Female; Lactation; Prolactin; Random Allocation; Rats; Rats, Wistar	1996
Chronic treatment with (-)-stepholidine alters density and turnover of D1 and D2 receptors in striatum. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:6 Topics: Animals; Berberine; Corpus Striatum; Dopamine Antagonists; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2	1996
[Antagonistic effect of tetrahydroproberberine homologues on alpha 1-adrenoceptor]. Yao xue xue bao = Acta pharmaceutica Sinica, 1996, Volume: 31, Issue:9 Topics: Adrenergic alpha-Antagonists; Animals; Berberine; Berberine Alkaloids; Binding, Competitive; Male; Rats; Receptors, Adrenergic, alpha-1; Vasoconstriction	1996
Mechanisms involved in the vasorelaxant effect of (-)-stepholidine in rat mesenteric small arteries. European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3 Topics: Animals; Berberine; Berberine Alkaloids; Calcium Channels; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Muscarinic; Serotonin	1999
(-)-Stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:1 Topics: Animals; Berberine; Corpus Striatum; Dopamine Antagonists; Polymyxin B; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase	1997
Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Berberine; Corpus Striatum; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Enzyme Inhibitors; Male; Nerve Tissue Proteins; Oxidopamine; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley	1998
Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:3 Topics: Analgesics, Non-Narcotic; Animals; Berberine; Berberine Alkaloids; Brain; Dopamine Agonists; Dopamine Antagonists; Formaldehyde; Male; Pain; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Spinal Cord; Spiperone	1999
[Differentiation-inducing effect of stepholidine and retinoic acid on human head and neck carcinoma]. Zhonghua er bi yan hou ke za zhi, 1997, Volume: 32, Issue:2 Topics: Berberine; Cell Differentiation; Cell Division; Humans; Laryngeal Neoplasms; Nasopharyngeal Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Protein p53	1997
Modulation of medical prefrontal cortical D1 receptors on the excitatory firing activity of nucleus accumbens neurons elicited by (-)-Stepholidine. Life sciences, 2000, Aug-04, Volume: 67, Issue:11 Topics: Animals; Berberine; Dopamine Agonists; Evoked Potentials; Iontophoresis; Male; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2000
Antagonistic effect of l-stepholidine on striatal ischemic injury in rat. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:12 Topics: Animals; Berberine; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Corpus Striatum; Ischemic Attack, Transient; L-Lactate Dehydrogenase; Male; Neurons; Rats; Rats, Sprague-Dawley	1999
Action sites of rotation and unit firing induced by l-stepholidine and DA agonists in basal ganglia of 6-OHDA-lesioned rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:11 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Berberine; Dopamine Agonists; Dopamine Antagonists; Electrophysiology; Male; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra	1999
Tetrahydroprotoberberines inhibit lipid peroxidation and scavenge hydroxyl free radicals. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:5 Topics: Animals; Antioxidants; Berberine; Berberine Alkaloids; Brain; Free Radical Scavengers; Hydroxyl Radical; Lipid Peroxidation; Liver; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley	2000
I-stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:7 Topics: Animals; Berberine; Dopamine; Male; Microinjections; Neurons; Nucleus Accumbens; Oxidopamine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2000
Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:10 Topics: Animals; Berberine; Dopamine Antagonists; Enkephalins; Gene Expression; Genes, fos; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rotation	2000
Electrophysiological study on biphasic firing activity elicited by D(1) agonistic-D(2) antagonistic action of (-)-stepholidine in nucleus accumbens. Sheng li xue bao : [Acta physiologica Sinica], 2000, Volume: 52, Issue:2 Topics: Animals; Berberine; Dopamine D2 Receptor Antagonists; Electrophysiology; Male; Neurons; Nucleus Accumbens; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2000
Increased phosphorylation of DARPP-32 by D1 agonistic action of l-stepholidine in the 6-OHDA-lesioned rat striatum. Sheng li xue bao : [Acta physiologica Sinica], 1999, Volume: 51, Issue:1 Topics: Animals; Berberine; Corpus Striatum; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Male; Nerve Tissue Proteins; Oxidopamine; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction	1999
[Determination of 7 bio-active alkaloids in Stephania plants by RP-HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:7 Topics: Alkaloids; Aporphines; Benzylisoquinolines; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Morphinans; Species Specificity; Stephania	1998
[Effects of l-stepholidine on the peripheral vascular dopamine DA1 and DA2 receptor subtypes]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:10 Topics: Animals; Berberine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Female; Fenoldopam; Male; Rabbits; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereoisomerism; Vasodilation	1998
(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro. Neuroreport, 2002, Nov-15, Volume: 13, Issue:16 Topics: Animals; Berberine; Brain-Derived Neurotrophic Factor; Cell Culture Techniques; Cell Differentiation; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Fibroblast Growth Factor 2; Haloperidol; Immunohistochemistry; Microtubule-Associated Proteins; Mitosis; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Tyrosine 3-Monooxygenase	2002
Effects of l-stepholidine on forebrain Fos expression: comparison with clozapine and haloperidol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:2 Topics: Animals; Antipsychotic Agents; Berberine; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Immunohistochemistry; Neostriatum; Nucleus Accumbens; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Septal Nuclei	2005
Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt. Neuroscience letters, 2005, Aug-05, Volume: 383, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Berberine; Blotting, Western; Cell Count; Cell Death; Cells, Cultured; Chromones; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Haloperidol; Hydrogen Peroxide; Morpholines; Neurons; Neuroprotective Agents; Prefrontal Cortex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Time Factors	2005
Effects of (-)stepholidine in animal models for schizophrenia. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:9 Topics: Animals; Antipsychotic Agents; Berberine; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Motor Activity; Plants, Medicinal; Rats; Rats, Wistar; Receptors, Dopamine D1; Schizophrenia; Stephania	2006
The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats. Neuropharmacology, 2007, Volume: 52, Issue:2 Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Berberine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Male; Morphine; Morphine Dependence; Motor Activity; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology	2007
Quantification of l-stepholidine in rat brain and plasma by high performance liquid chromatography combined with fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-01, Volume: 850, Issue:1-2 Topics: Animals; Berberine; Brain; Chromatography, High Pressure Liquid; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2007
l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons. Acta pharmacologica Sinica, 2007, Volume: 28, Issue:5 Topics: Animals; Berberine; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Postsynaptic Potentials; Humans; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction	2007
Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. Biophysical journal, 2007, Sep-01, Volume: 93, Issue:5 Topics: Animals; Berberine; Cattle; Computer Simulation; Dopamine; Dopamine D2 Receptor Antagonists; Imaging, Three-Dimensional; Models, Biological; Models, Chemical; Models, Molecular; Molecular Conformation; Plant Extracts; Receptors, Dopamine D1; Receptors, Dopamine D2; Signal Transduction; Software; Stephania	2007
Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine. Acta pharmacologica Sinica, 2007, Volume: 28, Issue:7 Topics: Animals; Antipsychotic Agents; Berberine; Calcium; Cell Line; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Protein Subunits; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate	2007
The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist. Psychopharmacology, 2008, Volume: 199, Issue:2 Topics: Amphetamine; Animals; Antipsychotic Agents; Avoidance Learning; Berberine; Brain Chemistry; Catalepsy; Central Nervous System Stimulants; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Genes, fos; Hallucinogens; Immunohistochemistry; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2	2008
L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. Neurobiology of aging, 2010, Volume: 31, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antiparkinson Agents; Antipsychotic Agents; Benzazepines; Berberine; CHO Cells; Corpus Striatum; Cricetinae; Cricetulus; Disease Models, Animal; Dopamine Agents; Drug Administration Schedule; Drug Interactions; Dyskinesias; Gene Expression Regulation; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; RNA, Messenger; Serotonin Receptor Agonists; Transfection; Tritium	2010
[Five alkaloids from vine stems of Diploclisia affinis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:21 Topics: Alkaloids; Aporphines; Benzylisoquinolines; Berberine; Drugs, Chinese Herbal; Ethanol; Magnetic Resonance Spectroscopy; Mass Spectrometry; Menispermaceae; Plant Stems; Spiro Compounds	2008
D(1)/D(2) receptor-targeting L-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice. Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1 Topics: Animals; Berberine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Electroencephalography; Electromyography; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Polysomnography; Preoptic Area; Proto-Oncogene Proteins c-fos; Reaction Time; Receptors, Dopamine D1; Signal Processing, Computer-Assisted; Sleep Initiation and Maintenance Disorders; Sleep Stages	2009
Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. Schizophrenia research, 2009, Volume: 115, Issue:1 Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Berberine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Inhibition, Psychological; Interpersonal Relations; Locomotion; Male; Phencyclidine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Recognition, Psychology; Reflex, Startle; Schizophrenia	2009
Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D(1) and antagonist at D(2) receptors, in rats. British journal of pharmacology, 2009, Volume: 158, Issue:5 Topics: Administration, Oral; Animals; Berberine; Biological Availability; Biological Transport; Brain; Caco-2 Cells; Cell Membrane Permeability; Cytosol; Dopamine D2 Receptor Antagonists; Female; Humans; In Vitro Techniques; Intestine, Small; Liver; Male; Microdialysis; Microsomes; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Species Specificity; Stereoisomerism; Tissue Extracts	2009
Enantioselective total synthesis of (-)-(S)-stepholidine. The Journal of organic chemistry, 2009, Dec-04, Volume: 74, Issue:23 Topics: Antipsychotic Agents; Berberine; Hydrogenation; Imines; Stereoisomerism	2009
l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse (New York, N.Y.), 2011, Volume: 65, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Berberine; Dextroamphetamine; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Neural Inhibition; Neurons; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists; Ventral Tegmental Area	2011
Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. The journal of physical chemistry. B, 2012, Jul-19, Volume: 116, Issue:28 Topics: Amino Acid Sequence; Berberine; Biological Products; Dopamine D2 Receptor Antagonists; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Receptors, Dopamine D1; Receptors, Dopamine D3	2012
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. Bioorganic & medicinal chemistry, 2013, Feb-15, Volume: 21, Issue:4 Topics: Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Microwaves; Motor Activity; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship	2013
L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats. Neuroreport, 2014, Jan-08, Volume: 25, Issue:1 Topics: Animals; Behavior, Animal; Berberine; Conditioning, Operant; Cues; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Extinction, Psychological; Heroin; Male; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reinforcement, Psychology; Self Administration	2014
L-stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement. Neuroscience letters, 2014, Jan-24, Volume: 559 Topics: Animals; Berberine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Extinction, Psychological; Heroin; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reinforcement, Psychology; Self Administration	2014
(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling. Psychopharmacology, 2015, Volume: 232, Issue:5 Topics: Animals; Arrestins; Berberine; beta-Arrestins; Brain; CHO Cells; Cricetulus; Dopamine Antagonists; GTP-Binding Proteins; HEK293 Cells; Humans; Receptors, Dopamine; Receptors, Dopamine D5; Signal Transduction	2015
L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway. Cell death & disease, 2015, Nov-05, Volume: 6 Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Berberine; Cyclic AMP-Dependent Protein Kinases; Dopamine Agonists; Male; Memory Disorders; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction	2015
Functional reversal of (-)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy. Chemical biology & drug design, 2016, Volume: 88, Issue:4 Topics: Benzazepines; Berberine; Binding Sites; Biological Assay; Dopamine D2 Receptor Antagonists; Humans; Models, Molecular; Receptors, Dopamine D1; Receptors, Dopamine D2	2016
Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. European journal of medicinal chemistry, 2017, Jan-05, Volume: 125 Topics: Animals; Berberine; Binding Sites; Cocaine-Related Disorders; Humans; Ligands; Molecular Docking Simulation; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship	2017
Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD. Scientific reports, 2017, 06-19, Volume: 7, Issue:1 Topics: Animals; Antidepressive Agents; Berberine; Cyclic AMP-Dependent Protein Kinases; Depressive Disorder, Major; Dopamine Antagonists; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Signal Transduction; TOR Serine-Threonine Kinases	2017
Dopamine D1-Like Receptor Agonist and D2-Like Receptor Antagonist (-)-Stepholidine Reduces Reinstatement of Drug-Seeking Behavior for 3,4-Methylenedioxypyrovalerone (MDPV) in Rats. ACS chemical neuroscience, 2018, 06-20, Volume: 9, Issue:6 Topics: Animals; Behavior, Animal; Benzodioxoles; Berberine; Cocaine; Dopamine Agonists; Dopamine Antagonists; Drug-Seeking Behavior; Extinction, Psychological; Humans; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Dopamine D1; Synthetic Cathinone	2018
(-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats. Drug and alcohol dependence, 2018, 08-01, Volume: 189 Topics: Animals; Berberine; Cocaine; Cues; Dopamine Agonists; Dopamine Antagonists; Extinction, Psychological; Locomotion; Male; Rats; Reinforcement, Psychology; Reward; Self Administration	2018
The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice. Neurotoxicity research, 2019, Volume: 36, Issue:2 Topics: Animals; Berberine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Locomotion; Male; Memory Disorders; Methamphetamine; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Random Allocation	2019
Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes. PloS one, 2019, Volume: 14, Issue:9 Topics: Amino Acids; Berberine; Binding Sites; Dopamine Antagonists; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Receptors, Dopamine D3; Thermodynamics; Water	2019
(-)-Stepholidine blocks expression, but not development, of cocaine conditioned place preference in rats. Neuroscience letters, 2020, 08-24, Volume: 734 Topics: Animals; Behavior, Animal; Berberine; Cocaine; Conditioning, Classical; Dopamine Antagonists; Dopamine Uptake Inhibitors; Extinction, Psychological; Male; Rats; Rats, Long-Evans	2020