berberine has been researched along with simvastatin in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Sashidhara, KV; Singh, SP | 1 |
| Jiang, JD; Kong, WJ; Pan, HN; Song, DQ; Wang, YM; Wei, J; You, XF; Zhao, LX; Zuo, ZY | 1 |
| Akhmedov, A; Holy, EW; Lüscher, TF; Tanner, FC | 1 |
| Jiang, W; Kou, J; Sun, L; Yu, B; Yuan, S | 1 |
| Gou, J; Li, A; Liu, J; Rao, G; Shi, J; Sun, J; Wang, S; Yang, J | 1 |
| Li, G; Liu, M; Su, X; Zhao, G; Zhao, L | 1 |
| Azike, CG; Baranowski, DC; Buchanan, B; Gabriele, J; Meng, Q; Poulin, MM; Zuccolo, J | 1 |
| Fang, L; Fang, Q; Feng, P; Guo, F; Li, B; Liang, Z; Xu, X; Zhan, G; Zhang, B; Zhao, L | 1 |
| Li, G; Qiu, F; Sun, Y; Zhao, L; Zhao, M | 1 |
| Feng, R; Ji, ZC; Jin, XY; Li, XM; Yang, FW; Zhang, BL; Zhang, JH; Zhang, LS; Zhang, MY; Zhao, MY | 1 |
| Ariga, K; Dall'Acqua, S; Ferrarese, I; Ferri, N; Giovanna Lupo, M; Hill, JP; Kumar Shrestha, L; Lal Swagat Shrestha, R; Maharjan, B; Panighel, G; Payne, DT; Rossi, I; Sharan Shrestha, S; Sut, S | 1 |
| Huang, G; Jiang, Y; Jing, W; Li, H; Li, X; Liang, B; Meng, Y; Tang, Q; Yang, H; Yang, X; Zhang, J; Zhang, L; Zhao, J; Zhou, F | 1 |
2 review(s) available for berberine and simvastatin
| Article | Year |
|---|---|
Lipid lowering agents of natural origin: An account of some promising chemotypes.
Topics: Animals; Biological Products; Dyslipidemias; Humans; Hypolipidemic Agents | 2017 |
Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
Topics: Berberine; Cholesterol; Databases, Bibliographic; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipoproteins, HDL; Lipoproteins, LDL; Phytotherapy; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome; Triglycerides | 2019 |
2 trial(s) available for berberine and simvastatin
| Article | Year |
|---|---|
Combination of simvastatin with berberine improves the lipid-lowering efficacy.
Topics: Animals; Berberine; Cholesterol, LDL; Drug Synergism; Drug Therapy, Combination; Fatty Liver; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Rats; Rats, Wistar; Receptors, LDL; RNA, Messenger; Simvastatin; Triglycerides; Up-Regulation | 2008 |
Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects.
Topics: Adult; Berberine; China; Chromatography, Liquid; Drug Administration Schedule; Drug Interactions; Female; Fenofibrate; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Simvastatin; Tandem Mass Spectrometry; Young Adult | 2019 |
9 other study(ies) available for berberine and simvastatin
| Article | Year |
|---|---|
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells.
Topics: Animals; Aorta; Berberine; Cell Line; Epithelial Cells; Humans; Hypolipidemic Agents; JNK Mitogen-Activated Protein Kinases; Lipoproteins; Male; Mice; Phosphorylation; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA Stability; Simvastatin; Thromboplastin; Tumor Necrosis Factor-alpha | 2009 |
A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity.
Topics: Berberine; Blood Coagulation Factors; Cells, Cultured; Chromogenic Compounds; Curcumin; Drug Evaluation, Preclinical; Endothelial Cells; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Lipoproteins; Simvastatin; Thromboplastin; Tumor Necrosis Factor-alpha | 2011 |
Combining human periodontal ligament cell membrane chromatography with online HPLC/MS for screening osteoplastic active compounds from Coptidis Rhizoma.
Topics: Adolescent; Adult; Alkaline Phosphatase; Analysis of Variance; Berberine; Cell Membrane; Cell Proliferation; Cell Survival; Cells, Cultured; Chromatography, Affinity; Chromatography, High Pressure Liquid; Coptis; Coptis chinensis; Drugs, Chinese Herbal; Extracellular Matrix; Humans; Mass Spectrometry; Periodontal Ligament; Simvastatin | 2012 |
Validated UPLC-MS/MS method for simultaneous determination of simvastatin, simvastatin hydroxy acid and berberine in rat plasma: Application to the drug-drug pharmacokinetic interaction study of simvastatin combined with berberine after oral administratio
Topics: Administration, Oral; Animals; Berberine; Chromatography, High Pressure Liquid; Drug Stability; Female; Limit of Detection; Linear Models; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Simvastatin; Tandem Mass Spectrometry | 2015 |
Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine.
Topics: Administration, Cutaneous; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Berberine; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Half-Life; Kidney; Limit of Detection; Liver; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Tandem Mass Spectrometry | 2018 |
The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins.
Topics: Action Potentials; Animals; Atorvastatin; Berberine; Cytochrome P-450 CYP3A; ERG1 Potassium Channel; Gene Expression; HEK293 Cells; Hep G2 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Long QT Syndrome; Microsomes, Liver; Rats; Simvastatin; Testosterone | 2018 |
Evaluation of the effects of natural isoquinoline alkaloids on low density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) in hepatocytes, as new potential hypocholesterolemic agents.
Topics: Berberine; Cholesterol; Hepatocytes; Isoquinolines; Proprotein Convertase 9; Receptors, LDL; Simvastatin; Subtilisin | 2022 |
Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
Topics: Animals; Berberine; Breast Neoplasms; Caveolin 1; Cholesterol; Extracellular Traps; Female; Histones; Humans; Lung Neoplasms; Membrane Proteins; Mice; Neutrophils; Simvastatin | 2022 |