berberine has been researched along with demethyleneberberine in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 7 (35.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dutour, R; Poirier, D | 1 |
| Jiang, SH; Pan, JF; Ren, JY; Yu, C; Zeng, JF; Zhang, H; Zhu, DY | 1 |
| Akao, T; Hattori, M; Nakamura, N; Zuo, F | 1 |
| Jiang, JD; Kong, WJ; Li, Y; Li, YH; Li, ZR; Ren, G; Song, DQ; Wang, YM; Wang, YX; Yang, P; Yi, H | 1 |
| Gao, CL; Ma, BL; Ma, YM; Qiu, FR; Wang, CH; Wang, XH; Wu, JS; Yao, MK; Zhong, J | 1 |
| Cheng, N; Ma, B; Ma, Y; Shi, R; Wang, C; Wang, X; Wu, D; Zhou, H | 1 |
| Liao, X; Liu, YM; Qing, LS; Shi, HL; Xiong, J; Xue, Y | 1 |
| Bin, W; Cao, S; Kang, N; Qiu, F; Wang, Y; Xu, P; Yan, J; Zhou, Y | 1 |
| Chen, H; Li, R; Liu, X; Ma, D; Qiang, X; Zhang, M; Zhang, P; Zhang, Y; Zhao, Z; Zhou, C | 1 |
| Fukuda, M; Hosoe, T; Ishikawa, K; Sato, F; Takeda, H; Wakana, D | 1 |
| Chen, H; Liu, X; Qiang, X; Wang, Y; Xu, L; Zhang, M; Zhang, P; Zhang, Y; Zhao, Z | 1 |
| Chen, H; Li, R; Qiang, X; Wang, Y; Yan, Y; Zhang, Y; Zhao, Z; Zhou, C | 1 |
| Chen, YY; Li, RY; Shi, MJ; Xu, XX; Yan, Y; Zhang, M; Zhang, YB; Zhao, XT; Zhao, YX | 1 |
| Li, Q; Li, R; Zhang, M; Zhang, Y; Zhao, Y; Zhou, C | 1 |
| Chen, J; Chen, YJ; Cui, GZ; Hu, SQ; Ma, M; Sun, KH; Tao, C; Wu, ZZ | 1 |
| Sheng, J; Shi, B; Sun, X; Wang, L; Wang, X; Wang, Z; Xie, Y; Yang, H; Zi, C | 1 |
| Li, R; Liu, D; Qiu, Z; Wen, J; Zhang, Y; Zhu, Q | 1 |
| Abdel-Daim, MM; Almeer, R; Dua, K; Gulati, M; Gupta, S; Gurjeet Singh, T; Khan, A; Kumar Singh, S; Najda, A; Sayed, AA; Vishwas, S | 1 |
| Chen, J; Huang, X; Ji, K; Liu, D; Liu, J; Tao, C; Zhang, R | 1 |
| Grewal, AK; Gupta, S; Khan, H; Saklani, P; Singh, TG | 1 |
2 review(s) available for berberine and demethyleneberberine
| Article | Year |
|---|---|
Inhibitors of cytochrome P450 (CYP) 1B1.
Topics: Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship | 2017 |
Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight.
Topics: Alkaloids; AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Antioxidants; Berberine; Humans; Neurodegenerative Diseases; Neuroprotective Agents; NF-kappa B | 2022 |
1 trial(s) available for berberine and demethyleneberberine
| Article | Year |
|---|---|
Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration.
Topics: Adult; Antidiarrheals; Berberine; Humans; Magnetic Resonance Spectroscopy; Male; Spectrometry, Mass, Electrospray Ionization; Sulfates | 2002 |
17 other study(ies) available for berberine and demethyleneberberine
| Article | Year |
|---|---|
Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry.
Topics: Animals; Bacteria; Berberine; Bile; Chromatography, Liquid; Germ-Free Life; Intestinal Absorption; Intestine, Small; Liver; Male; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2006 |
Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Biotransformation; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Isoenzymes; Liver; Male; Metabolic Detoxication, Phase I; Rats; Rats, Wistar; Receptor, Insulin; Receptors, LDL | 2011 |
Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Biological Availability; Coptis chinensis; Drugs, Chinese Herbal; Female; Glucuronides; Ileum; Inflammation; Intestinal Absorption; Intestinal Mucosa; Lipopolysaccharides; Male; Microsomes, Liver; Random Allocation; Rats; Rats, Sprague-Dawley | 2012 |
CYP450 1A2 and multiple UGT1A isoforms are responsible for jatrorrhizine metabolism in human liver microsomes.
Topics: Berberine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Gastrointestinal Agents; Glucuronides; Glucuronosyltransferase; Humans; Microsomes, Liver; Protein Isoforms; Recombinant Proteins | 2013 |
In vitro metabolic study of Rhizoma coptidis extract using liver microsomes immobilized on magnetic nanoparticles.
Topics: Animals; Berberine; Berberine Alkaloids; Bioreactors; Biotransformation; Chromatography, High Pressure Liquid; Coptis chinensis; Drugs, Chinese Herbal; Equipment Reuse; Kinetics; Magnetite Nanoparticles; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2013 |
Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells.
Topics: Berberine; Berberine Alkaloids; Berberis; Carcinoma, Hepatocellular; Coptis; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hypolipidemic Agents; Lipid Metabolism; Lipoproteins, LDL; Liver Neoplasms; Plant Extracts; Receptors, LDL; RNA, Messenger; Up-Regulation | 2014 |
Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Berberine; Cytochrome P-450 CYP2E1; Disease Models, Animal; Ethanol; Fatty Acids; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Diseases, Alcoholic; Male; Mice; Mitochondria; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Signal Transduction; Sirtuin 1; Transcription Factors | 2015 |
11-Hydroxylation of Protoberberine by the Novel Berberine-Utilizing Aerobic Bacterium Sphingobium sp. Strain BD3100.
Topics: Benzoflavones; Berberine; Berberine Alkaloids; Cytochrome P-450 Enzyme Inhibitors; Hydroxylation; Japan; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Sphingomonadaceae | 2015 |
Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Berberine; Enzyme Activation; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2016 |
Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-κB Signaling.
Topics: Actins; Animals; Apoptosis; Berberine; Cell Line; Collagen; Disease Models, Animal; Hepatic Stellate Cells; Liver Cirrhosis; Male; Matrix Metalloproteinases; Mice; Mice, Inbred ICR; NF-kappa B; Protective Agents; Rats; Signal Transduction; Smad Proteins; Thioacetamide; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta1 | 2016 |
Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Colon; Cytokines; Dextran Sulfate; Female; Homeostasis; Immunoglobulin G; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; NF-kappa B; RAW 264.7 Cells; Reactive Oxygen Species; Signal Transduction; Spleen; T-Lymphocytes, Helper-Inducer | 2017 |
Demethyleneberberine attenuates concanavalin A-induced autoimmune hepatitis in mice through inhibition of NF-κB and MAPK signaling.
Topics: Animals; Berberine; Concanavalin A; Cytokines; Hepatitis, Autoimmune; Liver; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Signal Transduction; Transcription Factor RelA | 2020 |
Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine.
Topics: Berberine; Berberine Alkaloids; Binding Sites; Dose-Response Relationship, Drug; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Plant Extracts | 2020 |
Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116.
Topics: Antineoplastic Agents; Apoptosis; Berberine; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; HCT116 Cells; Humans; Molecular Structure; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Tumor Cells, Cultured | 2021 |
Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice.
Topics: Animals; Berberine; Humans; Inflammasomes; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2021 |
Demethyleneberberine: A possible treatment for Huntington's disease.
Topics: Berberine; Humans; Huntington Disease; Neurodegenerative Diseases; Oxidative Stress | 2021 |
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway.
Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cellular Senescence; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Proto-Oncogene Proteins c-myc; Signal Transduction; Xenograft Model Antitumor Assays | 2021 |