bepridil has been researched along with verapamil in 110 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 62 (56.36) | 18.7374 |
1990's | 18 (16.36) | 18.2507 |
2000's | 16 (14.55) | 29.6817 |
2010's | 12 (10.91) | 24.3611 |
2020's | 2 (1.82) | 2.80 |
Authors | Studies |
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Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
Dubinsky, B; Moore, JB; Press, JB; Sanfilippo, PJ; Urbanski, M | 1 |
Topliss, JG; Yoshida, F | 1 |
Aszalos, A; Ibrahim, S; Knapton, A; Licht, T; Peggins, J | 1 |
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
Keserü, GM | 1 |
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
Cianchetta, G; Cruciani, G; Fravolini, A; Giesing, D; Singleton, RW; Vaz, RJ; Wildgoose, M; Zhang, M | 1 |
Nagashima, R; Nishikawa, T; Tobita, M | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
Jia, L; Sun, H | 1 |
Caron, G; Ermondi, G; Visentin, S | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Sen, S; Sinha, N | 1 |
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
Brouillette, WJ; Brown, GB; Zha, C | 1 |
Crevat, A; Gallice, P; Kovacic, H | 1 |
Baba, A; Matsuda, T; Shimizu, I | 1 |
Fabrègues, E; John, GW; Kamal, M; Massingham, R | 1 |
Boucher, M; Dubray, C; Duchêne-Marullaz, P | 1 |
Abe, T; Maseki, T; Tomita, T | 1 |
Haas, M; Punt, NC; van Amsterdam, FT; Zaagsma, J | 1 |
Huff, JW; Reinach, PS | 1 |
Kojima, M; Sperelakis, N | 1 |
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A | 1 |
Balwierczak, JL; Johnson, CL; Schwartz, A | 1 |
Haynes, DH; Jy, W | 1 |
Boddeke, HW; Heynis, JB; van Zwieten, PA; Wilffert, B | 1 |
Husted, SE; Krusell, LR; Nielsen, HK; Pluymers, RJ | 1 |
Lamar, JC; Leboeuf, J; Massingham, R; Ponsonnaille, J | 1 |
Beckeringh, JJ; Hugtenburg, JG; Mathy, MJ; van Zwieten, PA | 1 |
Allessie, MA; Bonke, FI; Kirchhof, CJ | 1 |
Lamar, JC; Leboeuf, J; Leoty, C; Massingham, R | 1 |
Berrios, A; Brink, D; del Castillo, J; Smith, DS | 1 |
Guerrant, RL; Ravdin, JI; Sperelakis, N | 2 |
Somberg, J | 1 |
Brown, NL; Sirugue, O; Worcel, M | 1 |
Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H | 1 |
Fosset, M; Galizzi, JP; Lazdunski, M | 2 |
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M | 1 |
Miller, RC; Schoeffter, P | 1 |
Hidaka, H; Itoh, H; Kusagawa, M; Shikano, K | 1 |
Adam, LP; Henderson, EG | 1 |
Borgia, MC; Federici, AR; Galli, V; Greco, V; Matteoli, S; Trappolini, M | 1 |
Kaltenbach, M; Khuri, SF; Marston, W; Reifart, N; Taylor, AD; Zierler, MK | 1 |
van Amsterdam, FT; Zaagsma, J | 1 |
Zannad, F | 1 |
Cartheuser, CF | 1 |
Da-Luz, PL; Da-Silveira, MC; Murad-Neto, A; Pileggi, F | 1 |
Chiba, S; Kobayashi, M; Ogiwara, Y; Shimotori, M | 1 |
Watts, JA | 1 |
Chollet-Debord, F; Duchene-Marullaz, P; Gachon, P; Moins, N | 1 |
Bowditch, J; Dow, JW; Nigdikar, SV | 1 |
Alatienne, M; Duchêne-Marullaz, P; Ghyselinck, N; Kantelip, JP; Talmant, JM | 1 |
Beaughard, M; Lamar, JC; Michelin, MT; Tisne-Versailles, J | 1 |
Dang Tran, L; Gaillard, G; Montastruc, JL; Montastruc, P; Valet, P | 1 |
Broxterman, HJ; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; van der Hoeven, JJ | 1 |
Hofmann, U; Kunkel, B; Mutschler, M | 1 |
Escoubet, B; Griffaton, G; Lechat, P; Samuel, JL | 1 |
Somberg, JC | 2 |
Feld, G; Nademanee, K; Piontek, M; Schwab, M; Singh, BN | 1 |
Balwierczak, J; Lathrop, DA; Matlib, MA; Schwartz, A | 1 |
Prystowsky, EN | 1 |
Krikler, DM; McKenna, WJ; Rowland, E | 1 |
Belhassen, B; Chagnac, A; Laniado, S; Pardo, Y; Pelleg, A; Shargordsky, B | 1 |
Martre, H; Singlas, E; Taburet, AM | 1 |
Lazdunski, M; Méaux, JP; Renaud, JF; Romey, G; Schmid, A | 1 |
Butler, B; Keren, G; Somberg, JC; Tepper, D; Torres, V | 1 |
Pang, DC; Sperelakis, N | 3 |
Mras, S; Sperelakis, N | 2 |
Jakobsen, P; Jespersen, LT; Mikkelsen, EO; Pedersen, OL | 1 |
Kerr, LM; Sperelakis, N | 2 |
Anno, T; Furuta, T; Itoh, M; Kodama, I; Toyama, J; Yamada, K | 1 |
Advenier, C; Cerrina, J; Duroux, P; Floch, A; Renier, A | 1 |
Campbell, JK; Marshall, RJ; Winslow, E | 1 |
Stoeckel, H; Takeda, K | 1 |
Chauvet-Monges, AM; Crevat, A; Salducci, MD; Tabouy, L | 1 |
Barbier-Brygoo, H; Guern, J; Thomine, S; Van Duijn, B; Zimmerman, S | 1 |
Wijnand, HP | 1 |
Abiko, Y; Chen, M; Hashizume, H; Xiao, CY | 1 |
Hasegawa, T; Matsushita, M; Nishimura, M; Satoh, E; Shimizu, Y; Taquahashi, Y | 1 |
Barhanin, J; Chouabe, C; Drici, MD; Lazdunski, M; Romey, G | 1 |
Hamar, J; Perner, F; Szende, B; Toronyi, E | 1 |
Dai, DZ; Jiang, JM | 1 |
Dong, C; Duffield, R; Ho, AK; Tang, T | 1 |
Cascio, WE; Chowdhury, MK; Crouse, JR; Jollis, JG; Massing, MW; Simpson, RJ; Smith, SC | 1 |
Fu, LW; Lin, GY; Pan, QC | 1 |
Bondioli, KR; Bonk, AJ; Macháty, Z; Prather, RS; Ramsoondar, JJ | 1 |
Avery, M; Fermini, B; Fossa, AA; Raunig, DL; Wang, E; Wisialowski, T; Wolfgang, E | 1 |
Toronyi, E | 1 |
Fossa, AA; Jeyaraj, D; Rosenbaum, DS; Said, TH; Wilson, LD | 1 |
Brown, AM; Bruening-Wright, A; Dittrich, HC; Hawryluk, P; Kramer, J; Obejero-Paz, CA; Tatalovic, M | 1 |
Hong, JM; Kim, J; Lee, SH; Ok, SH; Park, J; Shin, IW; Sohn, JT; Woo, MS | 1 |
Goto, A; Izumi-Nakaseko, H; Kambayashi, R; Kanda, Y; Kawai, S; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A; Takei, Y | 1 |
Hosomi, K; Komatsu, Y; Takegami, M; Yodoshi, M; Yokoyama, S | 1 |
3 review(s) available for bepridil and verapamil
Article | Year |
---|---|
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
[Clinical pharmacology of calcium inhibitors].
Topics: Age Factors; Animals; Bepridil; Biological Availability; Biotransformation; Calcium Channel Blockers; Diltiazem; Dogs; Half-Life; Humans; Intestinal Absorption; Kidney Failure, Chronic; Kinetics; Liver Diseases; Metabolic Clearance Rate; Nifedipine; Perhexiline; Protein Binding; Pyrrolidines; Rats; Tissue Distribution; Verapamil | 1985 |
[Role of apoptosis in the kidney after reperfusion].
Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Disease Models, Animal; Fendiline; Humans; Kidney Transplantation; Kidney Tubules; Monoamine Oxidase Inhibitors; Nifedipine; Reperfusion Injury; Selegiline; Vasodilator Agents; Verapamil | 2008 |
2 trial(s) available for bepridil and verapamil
Article | Year |
---|---|
Bepridil versus verapamil in stable angina pectoris--a controlled clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Bepridil; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Pyrrolidines; Random Allocation; Verapamil | 1989 |
[Bepridil in stable angina of effort: a double-blind comparison with verapamil].
Topics: Angina Pectoris; Bepridil; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Humans; Male; Middle Aged; Physical Exertion; Placebos; Pyrrolidines; Random Allocation; Verapamil | 1988 |
105 other study(ies) available for bepridil and verapamil
Article | Year |
---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.
Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Trachea | 1988 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Antiemetics; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Calcium Channel Blockers; Daunorubicin; Flow Cytometry; Humans; Mice; Transfection | 2000 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Fluoresceins; Fluorescent Dyes; Humans; Models, Molecular; Multivariate Analysis; Permeability; Quantitative Structure-Activity Relationship | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study.
Topics: Adenosine Triphosphate; Bepridil; Diltiazem; Erythrocytes; Humans; Kinetics; Nicardipine; Nifedipine; Ouabain; Potassium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1992 |
Na+ influx-induced decrease of (Na+ + K+)-ATPase activity in rat brain slices: role of Ca2+.
Topics: Amiloride; Animals; Bepridil; Brain; Calcium; Calcium Channel Blockers; Cell Membrane; Chelating Agents; Diazepam; Egtazic Acid; In Vitro Techniques; Kinetics; Male; Monensin; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Quinacrine; Rats; Rats, Inbred Strains; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil; Veratrine | 1991 |
Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists.
Topics: Animals; Bepridil; Caffeine; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Flunarizine; Kinetics; Lidoflazine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Renal Artery; Verapamil | 1991 |
Effects of bepridil, diltiazem and verapamil on atrial refractoriness and heart rate in the conscious dog: comparison with quinidine.
Topics: Animals; Arrhythmias, Cardiac; Atrial Function, Right; Bepridil; Blood Pressure; Diltiazem; Dogs; Female; Heart; Heart Rate; Male; Pressoreceptors; Quinidine; Tachycardia; Verapamil | 1991 |
Pharmacological properties of contraction caused by sodium removal in muscle strips isolated from canine coronary artery.
Topics: Amiloride; Animals; Arteries; Bepridil; Coronary Vessels; Dogs; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Ouabain; Phentolamine; Potassium; Sodium; Verapamil | 1990 |
Calcium antagonists show two modes of protection in ischemic heart failure.
Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diastole; Dose-Response Relationship, Drug; Male; Myocardial Contraction; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Mechanism of inhibition of net ion transport across frog corneal epithelium by calcium channel antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bepridil; Calcimycin; Calcium Channel Blockers; Cornea; Cyclic AMP; Diltiazem; Electric Conductivity; Epithelium; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Pyrrolidines; Rana catesbeiana; Sodium-Potassium-Exchanging ATPase; Verapamil | 1985 |
Effects of calcium channel blockers on ouabain-induced oscillatory afterpotentials in organ-cultured young embryonic chick hearts.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Chick Embryo; Diltiazem; Ion Channels; Nifedipine; Organ Culture Techniques; Ouabain; Pyrrolidines; Verapamil | 1986 |
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil | 1986 |
The relationship between the binding site of [3H]-d-cis-diltiazem and that of other non-dihydropyridine calcium entry blockers in cardiac sarcolemma.
Topics: Allosteric Regulation; Animals; Bepridil; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Diltiazem; Dogs; In Vitro Techniques; Ion Channels; Kinetics; Pyrrolidines; Sarcolemma; Verapamil | 1987 |
Thrombin-induced calcium movements in platelet activation.
Topics: Aminoquinolines; Bepridil; Biological Transport; Blood Platelets; Calcimycin; Calcium; Chlortetracycline; Fluorescence; Humans; Indomethacin; Ion Channels; Platelet Aggregation; Pyrrolidines; Thrombin; Verapamil | 1987 |
Investigation of the mechanism of negative inotropic activity of some calcium antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Arrhythmia Agents; Bepridil; Calcimycin; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Female; Flunarizine; Guinea Pigs; In Vitro Techniques; Lidoflazine; Male; Myocardial Contraction; Pyrrolidines; Verapamil | 1988 |
Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem.
Topics: Anesthesia; Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Sinoatrial Node; Time Factors; Verapamil | 1989 |
The differential effect of calcium antagonists on the positive inotropic effects induced by calcium and monensin in cardiac preparations of rats and guinea-pigs.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Diltiazem; Gallic Acid; Heart Ventricles; Lidoflazine; Male; Monensin; Myocardial Contraction; Nifedipine; Papillary Muscles; Rats; Rats, Inbred Strains; Ryanodine; Stimulation, Chemical; Verapamil | 1989 |
Effects of verapamil, diltiazem and disopyramide on sinus function: a comparison with bepridil.
Topics: Animals; Bepridil; Diltiazem; Disopyramide; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Pyrrolidines; Rabbits; Sinoatrial Node; Verapamil | 1989 |
Comparative effects of bepridil, its quaternary derivative CERM 11888 and verapamil on caffeine-induced contracture in ferret hearts.
Topics: Animals; Bepridil; Caffeine; Ferrets; In Vitro Techniques; Myocardial Contraction; Verapamil | 1989 |
Some properties of the action potentials conducted in the spines of the sea urchin Diadema antillarum.
Topics: Action Potentials; Animals; Axons; Barium; Bepridil; Cadmium; Calcium; Calcium Channel Blockers; Cobalt; Electric Conductivity; Electric Stimulation; Lanthanum; Manganese; Pyrrolidines; Sea Urchins; Strontium; Verapamil | 1985 |
Entamoeba histolytica: impedance measurements and cytotoxicity in the presence of bepridil, verapamil, and cytochalasin D.
Topics: Adhesiveness; Animals; Bepridil; Calcium Channel Blockers; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Cytochalasin D; Cytochalasins; Electric Conductivity; Entamoeba histolytica; Female; Ovary; Pyrrolidines; Temperature; Verapamil | 1985 |
The effects of some slow channel blocking drugs on high affinity serotonin uptake by rat brain synaptosomes.
Topics: Animals; Bepridil; Brain; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyrrolidines; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Temperature; Time Factors; Verapamil | 1986 |
A novel high affinity class of Ca2+ channel blockers.
Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil | 1988 |
Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (+/-)bepridil and (-)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes.
Topics: Barium; Benzazepines; Bepridil; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Kinetics; Magnesium; Membranes; Microtubules; Muscles; Pyrrolidines; Receptors, Nicotinic; Strontium; Verapamil | 1985 |
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil | 1986 |
Role of sodium-calcium exchange and effects of calcium entry blockers on endothelial-mediated responses in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Bepridil; Calcium; Calcium Channel Blockers; Choline; Cyclic GMP; Diltiazem; Endothelium; Female; Lithium; Muscle, Smooth, Vascular; Nicergoline; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Reserpine; Sodium; Verapamil | 1986 |
Protective effects of the calmodulin antagonist bepridil on ischaemia induced in the rat myocardium.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Bepridil; Calmodulin; Coronary Disease; Drug Interactions; Male; Myocardial Contraction; Myocardium; Myosin-Light-Chain Kinase; Pyrrolidines; Rats; Rats, Inbred Strains; Uncoupling Agents; Verapamil | 1986 |
Augmentation of succinylcholine-induced neuromuscular blockade by calcium channel antagonists.
Topics: Animals; Bepridil; Calcium Channel Blockers; Drug Synergism; In Vitro Techniques; Neuromuscular Junction; Nicardipine; Nifedipine; Pyrrolidines; Rana pipiens; Receptors, Nicotinic; Succinylcholine; Synaptic Transmission; Verapamil | 1986 |
Effects of bepridil on regional myocardial ischemia and comparison with verapamil.
Topics: Animals; Bepridil; Calcium Channel Blockers; Carbon Dioxide; Coronary Circulation; Coronary Disease; Dogs; Hydrogen-Ion Concentration; Myocardial Contraction; Myocardium; Pyrrolidines; Verapamil | 1986 |
Stereoisomers of calcium antagonists discriminate between coronary vascular and myocardial sites.
Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Vessels; Gallopamil; Heart; In Vitro Techniques; Male; Pyrrolidines; Rats; Stereoisomerism; Verapamil | 1988 |
[Pharmacology of calcium antagonists].
Topics: Bepridil; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Nifedipine; Pyrrolidines; Verapamil | 1988 |
Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat.
Topics: Animals; Bencyclane; Bepridil; Brain; Calcium Channel Blockers; Cinnarizine; Diltiazem; Electroencephalography; Fendiline; Flunarizine; Gallopamil; Heart Rate; Hypoxia; Nimodipine; Prenylamine; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration; Verapamil | 1988 |
Effects of calcium blockers on ventricular fibrillation during acute myocardial infarction.
Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Dogs; Myocardial Infarction; Myocardial Reperfusion; Pyrrolidines; Ventricular Fibrillation; Verapamil | 1988 |
Effects of calcium channel blockers on sinoatrial conduction in the isolated and blood-perfused dog atrium.
Topics: Animals; Bepridil; Calcium Channel Blockers; Dilazep; Diltiazem; Dogs; Heart Rate; In Vitro Techniques; Isoindoles; Myocardial Contraction; Phthalimides; Pyrrolidines; Sinoatrial Node; Verapamil | 1986 |
Protection of ischemic hearts by Ca2+ antagonists.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Energy Metabolism; Lactates; Lactic Acid; Mitochondria, Heart; Myocardial Contraction; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Comparison of verapamil and bepridil, two slow channel inhibitors, in protection against calcium-induced arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Blood Pressure; Calcium; Electrocardiography; Heart Rate; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1986 |
Calcium antagonists and adenine nucleotide metabolism in rat heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Bepridil; Calcium Channel Blockers; Heart; Myocardium; Nifedipine; Nisoldipine; Pyrrolidines; Rats; Verapamil | 1986 |
Comparative electrophysiologic effects of bepridil, verapamil and diltiazem in conscious and anesthetized dogs.
Topics: Anesthesia, General; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart Conduction System; Hemodynamics; Male; Pentobarbital; Pyrrolidines; Sinoatrial Node; Verapamil | 1986 |
Comparative effects of bepridil, diltiazem, nifedipine and verapamil on haemodynamic parameters and myocardial oxygen consumption in anaesthetized dogs.
Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Female; Heart; Hemodynamics; Male; Myocardium; Nifedipine; Oxygen Consumption; Pyrrolidines; Vascular Resistance; Verapamil | 1986 |
Effects of calcium entry blockers on blood pressure and heart rate in neurogenic hypertensive dogs.
Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Denervation; Diltiazem; Dogs; Female; Heart Rate; Hypertension; Male; Nicardipine; Nifedipine; Pyrrolidines; Sinoatrial Node; Verapamil | 1987 |
Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil.
Topics: Bepridil; Calcium Channel Blockers; Calmodulin; Cell Line; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; Ovarian Neoplasms; Pyrrolidines; Tumor Cells, Cultured; Verapamil | 1987 |
Comparison of verapamil and bepridil in the therapy of familiar cardiomyopathy of the Syrian hamster.
Topics: Animals; Bepridil; Calcium; Cardiomyopathies; Cricetinae; Muscles; Necrosis; Osmolar Concentration; Pyrrolidines; Verapamil | 1987 |
Calcium antagonists stimulate prostaglandin synthesis by cultured rat cardiac myocytes and prevent the effects of hypoxia.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cells, Cultured; Cobalt; Diltiazem; Dinoprostone; Epoprostenol; Fibroblasts; Glycogen; Heart; Hypoxia; Myocardium; Prostaglandins E; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Calcium channel blockers that prolong the QT interval.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Dogs; Electrocardiography; Heart Atria; Heart Ventricles; Humans; Lidoflazine; Pyrrolidines; Quinidine; Systole; Verapamil | 1985 |
Comparative electrophysiologic profiles of calcium antagonists with particular reference to bepridil.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Heart Conduction System; Humans; Male; Middle Aged; Pyrrolidines; Sinoatrial Node; Verapamil | 1985 |
Pharmacology of calcium antagonists.
Topics: Action Potentials; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Guinea Pigs; Heart; Heart Rate; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pyrrolidines; Rats; Vasodilation; Ventricular Fibrillation; Verapamil | 1985 |
Electrophysiologic and antiarrhythmic properties of bepridil.
Topics: Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Electrocardiography; Electrophysiology; Heart Conduction System; Heart Rate; Humans; Pyrrolidines; Tachycardia; Verapamil | 1985 |
Electrophysiologic and antiarrhythmic actions of bepridil. Comparison with verapamil and ajmaline for atrioventricular reentrant tachycardia.
Topics: Ajmaline; Anti-Arrhythmia Agents; Atrioventricular Node; Bepridil; Electrophysiology; Humans; Pyrrolidines; Tachycardia; Verapamil | 1985 |
Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Constriction; Coronary Vessels; Dogs; Female; Heart Rate; Male; Pyrrolidines; Ventricular Fibrillation; Verapamil | 1985 |
Properties of receptors for the Ca2+-channel blocker verapamil in transverse-tubule membranes of skeletal muscle. Stereospecificity, effect of Ca2+ and other inorganic cations, evidence for two categories of sites and effect of nucleoside triphosphates.
Topics: Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channels; Cations, Divalent; Cations, Monovalent; Diltiazem; Electrochemistry; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Muscles; Nifedipine; Nitrendipine; Nucleotides; Pyrrolidines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1984 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
Activation of the voltage-dependent Ca2+ channel in rat heart cells by dihydropyridine derivatives.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bepridil; Calcium; Dose-Response Relationship, Drug; Ion Channels; Myocardium; Nifedipine; Pyridines; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1984 |
Effect of ion channel inhibitors on the cytopathogenicity of Entamoeba histolytica.
Topics: Adhesiveness; Animals; Bepridil; Calcium; Cell Line; Cell Survival; Cricetinae; Entamoeba histolytica; Female; Ion Channels; Ovary; Pyrrolidines; Sodium; Tetrodotoxin; Verapamil | 1982 |
The effect of bepridil, verapamil, and quinidine in the prevention of ventricular tachycardia induced by programmed electrical stimulation in the digitalized dog.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Male; Pyrrolidines; Quinidine; Tachycardia; Verapamil | 1984 |
Nifedipine, diltiazem, bepridil and verapamil uptakes into cardiac and smooth muscles.
Topics: Animals; Benzazepines; Bepridil; Calcium Channel Blockers; Cats; Chick Embryo; Diltiazem; Ileum; In Vitro Techniques; Muscle, Smooth; Myocardium; Nifedipine; Papillary Muscles; Pyridines; Pyrrolidines; Rabbits; Time Factors; Verapamil | 1983 |
Depression of contractions of rabbit aorta and guinea pig vena cava by mesudipine and other slow channel blockers.
Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium; Pyridines; Pyrrolidines; Rabbits; Vena Cava, Inferior; Verapamil | 1983 |
Drinking water and drug dosage in rat studies.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Bepridil; Blood Pressure; Dose-Response Relationship, Drug; Drinking; Hydralazine; Hypertension; Indapamide; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil | 1983 |
Ca2+-dependent slow action potentials in normal and dystrophic mouse skeletal muscle.
Topics: Action Potentials; Animals; Bepridil; Calcium; Glycerol; Kinetics; Lanthanum; Manganese; Mice; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal; Pyrrolidines; Uncoupling Agents; Verapamil | 1983 |
Electromechanical effects of bepridil on rabbit isolated hearts.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Bepridil; Bundle of His; Electric Stimulation; Electrophysiology; Heart; Heart Rate; In Vitro Techniques; Lidocaine; Pyrrolidines; Rabbits; Verapamil | 1984 |
Uptake of calcium antagonistic drugs into muscles as related to their lipid solubilities.
Topics: Animals; Bepridil; Calcium Channel Blockers; Lipid Metabolism; Muscles; Nifedipine; Nitrendipine; Pyrrolidines; Rana pipiens; Rats; Sarcoplasmic Reticulum; Solubility; Verapamil | 1984 |
Effects of five different organic calcium antagonists on guinea-pig isolated trachea.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicardipine; Nifedipine; Pyrrolidines; Trachea; Verapamil | 1984 |
Bepridil (CERM-1978) an verapamil depression of contractions of rabbit aortic rings.
Topics: Animals; Aorta; Bepridil; Calcium; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Pyrrolidines; Rabbits; Verapamil | 1981 |
Effect of the calcium antagonists bepridil (CERM-1978) and verapamil on Ca++-dependent slow action potentials in frog skeletal muscle.
Topics: Action Potentials; Animals; Bepridil; Calcium; Calcium Channel Blockers; Glycerol; In Vitro Techniques; Microtubules; Muscles; Pyrrolidines; Rana pipiens; Verapamil | 1982 |
Differential actions of calcium antagonists on calcium binding to cardiac sarcolemma.
Topics: Animals; Bepridil; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Guinea Pigs; In Vitro Techniques; Myocardium; Nifedipine; Pyrrolidines; Sarcolemma; Verapamil | 1982 |
Comparative effects of bepridil and verapamil on isolated coronary and systemic vascular and cardiac muscle.
Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Chloride; Coronary Vessels; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Papillary Muscles; Potassium Chloride; Pyrrolidines; Rabbits; Swine; Verapamil | 1982 |
Calcium-sensitivity of the plasmalemmal delayed rectifier potassium current suggests that calcium influx in pulvinar protoplasts from Mimosa pudica L. can be revealed by hyperpolarization.
Topics: Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Electric Conductivity; Ionomycin; Ionophores; Nitrendipine; Plant Physiological Phenomena; Potassium Channels; Protoplasts; Pulvinus; Verapamil | 1995 |
Protective effect of some calcium antagonists against mitochondrial calcium injury.
Topics: Adenosine Triphosphate; Amlodipine; Animals; Antihypertensive Agents; Bepridil; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Mitochondria, Liver; Myocardial Ischemia; Nicardipine; Rats; Rats, Wistar; Verapamil | 1994 |
Calcium channel antagonists induce direct inhibition of the outward rectifying potassium channel in tobacco protoplasts.
Topics: Bepridil; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; Membrane Potentials; Nicotiana; Nifedipine; Plants, Toxic; Potassium Channel Blockers; Protoplasts; Verapamil | 1994 |
Bioequivalence revisited: non-parametric analysis of two-period cross-over studies.
Topics: Algorithms; Analysis of Variance; Angina Pectoris; Bepridil; Computer Simulation; Confidence Intervals; Delayed-Action Preparations; Double-Blind Method; Humans; Isosorbide Dinitrate; Male; Mathematical Computing; Reference Values; Software; Theophylline; Therapeutic Equivalency; Verapamil | 1993 |
Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes.
Topics: Animals; Benzofurans; Bepridil; Calcium; Calcium Channel Blockers; Cell Size; Cells, Cultured; Creatine Kinase; Dose-Response Relationship, Drug; Ethers, Cyclic; Flunarizine; Fura-2; Heart; Lysophosphatidylcholines; Male; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channels; Verapamil | 1997 |
Twitch potentiation induced by caffeine in the mouse diaphragm depends on external calcium ions in the absence of potassium ions.
Topics: Animals; Bepridil; Caffeine; Calcium; Calcium Channel Blockers; Diaphragm; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Skeletal; Potassium; Verapamil | 1997 |
HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers.
Topics: Animals; Benzimidazoles; Bepridil; Calcium Channel Blockers; Cloning, Molecular; COS Cells; Heart; Ion Channel Gating; Long QT Syndrome; Membrane Potentials; Mibefradil; Potassium Channels; Tetrahydronaphthalenes; Transfection; Verapamil | 1998 |
Prevention of apoptosis reperfusion renal injury by calcium channel blockers.
Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Fendiline; Kidney; Kidney Tubules; Male; Nifedipine; Rats; Rats, Wistar; Reperfusion Injury; Severity of Illness Index; Time Factors; Verapamil | 1999 |
p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+.
Topics: Animals; Aorta, Thoracic; Bepridil; Berberine; Biological Transport, Active; Calcium; Calcium Channel Blockers; Female; Hyperthyroidism; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth, Vascular; Nimodipine; Rats; Rats, Sprague-Dawley; Thyroxine; Verapamil | 1998 |
Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia.
Topics: Adenosine Triphosphate; Animals; Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Creatine Kinase; Glyburide; Homeostasis; Hyperkalemia; Myocardium; Pinacidil; Potassium Channels; Potassium Chloride; Sodium-Calcium Exchanger; Verapamil | 1999 |
Calcium channel blockers and mortality in elderly patients with myocardial infarction.
Topics: Aged; Aged, 80 and over; Amlodipine; Bepridil; Calcium Channel Blockers; Diltiazem; Female; Humans; Logistic Models; Male; Myocardial Infarction; Nifedipine; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; United States; Verapamil | 1999 |
[Compared study on Fura-2/AM assay and MTT assay for screening multidrug resistant modulators].
Topics: Bepridil; Breast Neoplasms; Calcium Channel Blockers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fura-2; Humans; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Verapamil | 1997 |
Na(+)/Ca(2+) exchanger in porcine oocytes.
Topics: Amiloride; Animals; Base Sequence; Bepridil; Calcium; Calcium Channel Blockers; Cell Membrane; Cloning, Molecular; Enzyme Inhibitors; Female; Fluorescent Dyes; Fura-2; Immunohistochemistry; Molecular Sequence Data; Oocytes; Ouabain; Pimozide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Swine; Verapamil | 2002 |
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
Topics: Animals; Antipsychotic Agents; Bepridil; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cisapride; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Guinea Pigs; Heart Rate; Histamine H1 Antagonists; Humans; In Vitro Techniques; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Risperidone; Terfenadine; Verapamil | 2004 |
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Ether-A-Go-Go Potassium Channels; Heart Conduction System; Humans; In Vitro Techniques; Long QT Syndrome; Piperidines; Potassium Channel Blockers; Pyridines; Risk Assessment; Risperidone; Time Factors; Torsades de Pointes; Toxicity Tests; Verapamil; Voltage-Sensitive Dye Imaging | 2012 |
Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
Topics: Action Potentials; Animals; Bepridil; CHO Cells; Computer Simulation; Cricetulus; Ether-A-Go-Go Potassium Channels; Heart; HEK293 Cells; Humans; Inhibitory Concentration 50; Ion Channels; Membrane Potentials; Models, Biological; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperazines; Sulfonamides; Verapamil | 2015 |
Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
Topics: Animals; Aorta, Thoracic; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Emulsions; In Vitro Techniques; Male; Nifedipine; Phenylephrine; Phospholipids; Rats; Rats, Sprague-Dawley; Soybean Oil; Vasodilation; Vasodilator Agents; Verapamil | 2018 |
Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
Topics: Animals; Atrioventricular Block; Bepridil; Cisapride; Computer Simulation; Macaca fascicularis; Sotalol; Torsades de Pointes; Verapamil | 2021 |
Association between hemorrhage and direct oral anticoagulants in combination with verapamil: Analysis of Japanese Adverse Drug Event Report database and electronic medical record data.
Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Anticoagulants; Atrial Fibrillation; Bepridil; Cohort Studies; East Asian People; Electronic Health Records; Hemorrhage; Humans; Verapamil | 2023 |