bepridil and verapamil

bepridil has been researched along with verapamil in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-199062 (56.36)18.7374
1990's18 (16.36)18.2507
2000's16 (14.55)29.6817
2010's12 (10.91)24.3611
2020's2 (1.82)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Dubinsky, B; Moore, JB; Press, JB; Sanfilippo, PJ; Urbanski, M1
Topliss, JG; Yoshida, F1
Aszalos, A; Ibrahim, S; Knapton, A; Licht, T; Peggins, J1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Keserü, GM1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA1
Cianchetta, G; Cruciani, G; Fravolini, A; Giesing, D; Singleton, RW; Vaz, RJ; Wildgoose, M; Zhang, M1
Nagashima, R; Nishikawa, T; Tobita, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Jia, L; Sun, H1
Caron, G; Ermondi, G; Visentin, S1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Sen, S; Sinha, N1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Brouillette, WJ; Brown, GB; Zha, C1
Crevat, A; Gallice, P; Kovacic, H1
Baba, A; Matsuda, T; Shimizu, I1
Fabrègues, E; John, GW; Kamal, M; Massingham, R1
Boucher, M; Dubray, C; Duchêne-Marullaz, P1
Abe, T; Maseki, T; Tomita, T1
Haas, M; Punt, NC; van Amsterdam, FT; Zaagsma, J1
Huff, JW; Reinach, PS1
Kojima, M; Sperelakis, N1
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A1
Balwierczak, JL; Johnson, CL; Schwartz, A1
Haynes, DH; Jy, W1
Boddeke, HW; Heynis, JB; van Zwieten, PA; Wilffert, B1
Husted, SE; Krusell, LR; Nielsen, HK; Pluymers, RJ1
Lamar, JC; Leboeuf, J; Massingham, R; Ponsonnaille, J1
Beckeringh, JJ; Hugtenburg, JG; Mathy, MJ; van Zwieten, PA1
Allessie, MA; Bonke, FI; Kirchhof, CJ1
Lamar, JC; Leboeuf, J; Leoty, C; Massingham, R1
Berrios, A; Brink, D; del Castillo, J; Smith, DS1
Guerrant, RL; Ravdin, JI; Sperelakis, N2
Somberg, J1
Brown, NL; Sirugue, O; Worcel, M1
Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H1
Fosset, M; Galizzi, JP; Lazdunski, M2
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M1
Miller, RC; Schoeffter, P1
Hidaka, H; Itoh, H; Kusagawa, M; Shikano, K1
Adam, LP; Henderson, EG1
Borgia, MC; Federici, AR; Galli, V; Greco, V; Matteoli, S; Trappolini, M1
Kaltenbach, M; Khuri, SF; Marston, W; Reifart, N; Taylor, AD; Zierler, MK1
van Amsterdam, FT; Zaagsma, J1
Zannad, F1
Cartheuser, CF1
Da-Luz, PL; Da-Silveira, MC; Murad-Neto, A; Pileggi, F1
Chiba, S; Kobayashi, M; Ogiwara, Y; Shimotori, M1
Watts, JA1
Chollet-Debord, F; Duchene-Marullaz, P; Gachon, P; Moins, N1
Bowditch, J; Dow, JW; Nigdikar, SV1
Alatienne, M; Duchêne-Marullaz, P; Ghyselinck, N; Kantelip, JP; Talmant, JM1
Beaughard, M; Lamar, JC; Michelin, MT; Tisne-Versailles, J1
Dang Tran, L; Gaillard, G; Montastruc, JL; Montastruc, P; Valet, P1
Broxterman, HJ; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; van der Hoeven, JJ1
Hofmann, U; Kunkel, B; Mutschler, M1
Escoubet, B; Griffaton, G; Lechat, P; Samuel, JL1
Somberg, JC2
Feld, G; Nademanee, K; Piontek, M; Schwab, M; Singh, BN1
Balwierczak, J; Lathrop, DA; Matlib, MA; Schwartz, A1
Prystowsky, EN1
Krikler, DM; McKenna, WJ; Rowland, E1
Belhassen, B; Chagnac, A; Laniado, S; Pardo, Y; Pelleg, A; Shargordsky, B1
Martre, H; Singlas, E; Taburet, AM1
Lazdunski, M; Méaux, JP; Renaud, JF; Romey, G; Schmid, A1
Butler, B; Keren, G; Somberg, JC; Tepper, D; Torres, V1
Pang, DC; Sperelakis, N3
Mras, S; Sperelakis, N2
Jakobsen, P; Jespersen, LT; Mikkelsen, EO; Pedersen, OL1
Kerr, LM; Sperelakis, N2
Anno, T; Furuta, T; Itoh, M; Kodama, I; Toyama, J; Yamada, K1
Advenier, C; Cerrina, J; Duroux, P; Floch, A; Renier, A1
Campbell, JK; Marshall, RJ; Winslow, E1
Stoeckel, H; Takeda, K1
Chauvet-Monges, AM; Crevat, A; Salducci, MD; Tabouy, L1
Barbier-Brygoo, H; Guern, J; Thomine, S; Van Duijn, B; Zimmerman, S1
Wijnand, HP1
Abiko, Y; Chen, M; Hashizume, H; Xiao, CY1
Hasegawa, T; Matsushita, M; Nishimura, M; Satoh, E; Shimizu, Y; Taquahashi, Y1
Barhanin, J; Chouabe, C; Drici, MD; Lazdunski, M; Romey, G1
Hamar, J; Perner, F; Szende, B; Toronyi, E1
Dai, DZ; Jiang, JM1
Dong, C; Duffield, R; Ho, AK; Tang, T1
Cascio, WE; Chowdhury, MK; Crouse, JR; Jollis, JG; Massing, MW; Simpson, RJ; Smith, SC1
Fu, LW; Lin, GY; Pan, QC1
Bondioli, KR; Bonk, AJ; Macháty, Z; Prather, RS; Ramsoondar, JJ1
Avery, M; Fermini, B; Fossa, AA; Raunig, DL; Wang, E; Wisialowski, T; Wolfgang, E1
Toronyi, E1
Fossa, AA; Jeyaraj, D; Rosenbaum, DS; Said, TH; Wilson, LD1
Brown, AM; Bruening-Wright, A; Dittrich, HC; Hawryluk, P; Kramer, J; Obejero-Paz, CA; Tatalovic, M1
Hong, JM; Kim, J; Lee, SH; Ok, SH; Park, J; Shin, IW; Sohn, JT; Woo, MS1
Goto, A; Izumi-Nakaseko, H; Kambayashi, R; Kanda, Y; Kawai, S; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A; Takei, Y1
Hosomi, K; Komatsu, Y; Takegami, M; Yodoshi, M; Yokoyama, S1

Reviews

3 review(s) available for bepridil and verapamil

ArticleYear
Antiarrhythmic drug therapy. Recent advances and current status.
    Cardiology, 1985, Volume: 72, Issue:5-6

    Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil

1985
[Clinical pharmacology of calcium inhibitors].
    Archives des maladies du coeur et des vaisseaux, 1985, Volume: 78 Spec No

    Topics: Age Factors; Animals; Bepridil; Biological Availability; Biotransformation; Calcium Channel Blockers; Diltiazem; Dogs; Half-Life; Humans; Intestinal Absorption; Kidney Failure, Chronic; Kinetics; Liver Diseases; Metabolic Clearance Rate; Nifedipine; Perhexiline; Protein Binding; Pyrrolidines; Rats; Tissue Distribution; Verapamil

1985
[Role of apoptosis in the kidney after reperfusion].
    Orvosi hetilap, 2008, Feb-17, Volume: 149, Issue:7

    Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Disease Models, Animal; Fendiline; Humans; Kidney Transplantation; Kidney Tubules; Monoamine Oxidase Inhibitors; Nifedipine; Reperfusion Injury; Selegiline; Vasodilator Agents; Verapamil

2008

Trials

2 trial(s) available for bepridil and verapamil

ArticleYear
Bepridil versus verapamil in stable angina pectoris--a controlled clinical trial.
    International journal of cardiology, 1989, Volume: 23, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Bepridil; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Pyrrolidines; Random Allocation; Verapamil

1989
[Bepridil in stable angina of effort: a double-blind comparison with verapamil].
    Cardiologia (Rome, Italy), 1988, Volume: 33, Issue:4

    Topics: Angina Pectoris; Bepridil; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Humans; Male; Middle Aged; Physical Exertion; Placebos; Pyrrolidines; Random Allocation; Verapamil

1988

Other Studies

105 other study(ies) available for bepridil and verapamil

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:11

    Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Trachea

1988
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Antiemetics; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Calcium Channel Blockers; Daunorubicin; Flow Cytometry; Humans; Mice; Transfection

2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2004
A two-state homology model of the hERG K+ channel: application to ligand binding.
    Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation

2005
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.
    Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Fluoresceins; Fluorescent Dyes; Humans; Models, Molecular; Multivariate Analysis; Permeability; Quantitative Structure-Activity Relationship

2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Nov-27, Volume: 104, Issue:48

    Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers

2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5

    Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
    Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1

    Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels

2014
Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study.
    Biochemical pharmacology, 1992, Oct-20, Volume: 44, Issue:8

    Topics: Adenosine Triphosphate; Bepridil; Diltiazem; Erythrocytes; Humans; Kinetics; Nicardipine; Nifedipine; Ouabain; Potassium; Sodium-Potassium-Exchanging ATPase; Verapamil

1992
Na+ influx-induced decrease of (Na+ + K+)-ATPase activity in rat brain slices: role of Ca2+.
    European journal of pharmacology, 1991, Nov-12, Volume: 204, Issue:3

    Topics: Amiloride; Animals; Bepridil; Brain; Calcium; Calcium Channel Blockers; Cell Membrane; Chelating Agents; Diazepam; Egtazic Acid; In Vitro Techniques; Kinetics; Male; Monensin; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Quinacrine; Rats; Rats, Inbred Strains; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil; Veratrine

1991
Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists.
    European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3

    Topics: Animals; Bepridil; Caffeine; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Flunarizine; Kinetics; Lidoflazine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Renal Artery; Verapamil

1991
Effects of bepridil, diltiazem and verapamil on atrial refractoriness and heart rate in the conscious dog: comparison with quinidine.
    General pharmacology, 1991, Volume: 22, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Atrial Function, Right; Bepridil; Blood Pressure; Diltiazem; Dogs; Female; Heart; Heart Rate; Male; Pressoreceptors; Quinidine; Tachycardia; Verapamil

1991
Pharmacological properties of contraction caused by sodium removal in muscle strips isolated from canine coronary artery.
    European journal of pharmacology, 1990, Nov-13, Volume: 190, Issue:3

    Topics: Amiloride; Animals; Arteries; Bepridil; Coronary Vessels; Dogs; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Ouabain; Phentolamine; Potassium; Sodium; Verapamil

1990
Calcium antagonists show two modes of protection in ischemic heart failure.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:1

    Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diastole; Dose-Response Relationship, Drug; Male; Myocardial Contraction; Nifedipine; Rats; Rats, Inbred Strains; Verapamil

1990
Mechanism of inhibition of net ion transport across frog corneal epithelium by calcium channel antagonists.
    The Journal of membrane biology, 1985, Volume: 85, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bepridil; Calcimycin; Calcium Channel Blockers; Cornea; Cyclic AMP; Diltiazem; Electric Conductivity; Epithelium; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Pyrrolidines; Rana catesbeiana; Sodium-Potassium-Exchanging ATPase; Verapamil

1985
Effects of calcium channel blockers on ouabain-induced oscillatory afterpotentials in organ-cultured young embryonic chick hearts.
    European journal of pharmacology, 1986, Mar-11, Volume: 122, Issue:1

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Chick Embryo; Diltiazem; Ion Channels; Nifedipine; Organ Culture Techniques; Ouabain; Pyrrolidines; Verapamil

1986
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
    Journal of cardiovascular pharmacology, 1986, Volume: 8 Suppl 8

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil

1986
The relationship between the binding site of [3H]-d-cis-diltiazem and that of other non-dihydropyridine calcium entry blockers in cardiac sarcolemma.
    Molecular pharmacology, 1987, Volume: 31, Issue:2

    Topics: Allosteric Regulation; Animals; Bepridil; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Diltiazem; Dogs; In Vitro Techniques; Ion Channels; Kinetics; Pyrrolidines; Sarcolemma; Verapamil

1987
Thrombin-induced calcium movements in platelet activation.
    Biochimica et biophysica acta, 1987, Jun-15, Volume: 929, Issue:1

    Topics: Aminoquinolines; Bepridil; Biological Transport; Blood Platelets; Calcimycin; Calcium; Chlortetracycline; Fluorescence; Humans; Indomethacin; Ion Channels; Platelet Aggregation; Pyrrolidines; Thrombin; Verapamil

1987
Investigation of the mechanism of negative inotropic activity of some calcium antagonists.
    Journal of cardiovascular pharmacology, 1988, Volume: 11, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Arrhythmia Agents; Bepridil; Calcimycin; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Female; Flunarizine; Guinea Pigs; In Vitro Techniques; Lidoflazine; Male; Myocardial Contraction; Pyrrolidines; Verapamil

1988
Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem.
    British journal of pharmacology, 1989, Volume: 98, Issue:4

    Topics: Anesthesia; Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Sinoatrial Node; Time Factors; Verapamil

1989
The differential effect of calcium antagonists on the positive inotropic effects induced by calcium and monensin in cardiac preparations of rats and guinea-pigs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:5

    Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Diltiazem; Gallic Acid; Heart Ventricles; Lidoflazine; Male; Monensin; Myocardial Contraction; Nifedipine; Papillary Muscles; Rats; Rats, Inbred Strains; Ryanodine; Stimulation, Chemical; Verapamil

1989
Effects of verapamil, diltiazem and disopyramide on sinus function: a comparison with bepridil.
    European journal of pharmacology, 1989, Feb-07, Volume: 160, Issue:3

    Topics: Animals; Bepridil; Diltiazem; Disopyramide; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Pyrrolidines; Rabbits; Sinoatrial Node; Verapamil

1989
Comparative effects of bepridil, its quaternary derivative CERM 11888 and verapamil on caffeine-induced contracture in ferret hearts.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: Animals; Bepridil; Caffeine; Ferrets; In Vitro Techniques; Myocardial Contraction; Verapamil

1989
Some properties of the action potentials conducted in the spines of the sea urchin Diadema antillarum.
    Comparative biochemistry and physiology. A, Comparative physiology, 1985, Volume: 81, Issue:1

    Topics: Action Potentials; Animals; Axons; Barium; Bepridil; Cadmium; Calcium; Calcium Channel Blockers; Cobalt; Electric Conductivity; Electric Stimulation; Lanthanum; Manganese; Pyrrolidines; Sea Urchins; Strontium; Verapamil

1985
Entamoeba histolytica: impedance measurements and cytotoxicity in the presence of bepridil, verapamil, and cytochalasin D.
    Experimental parasitology, 1985, Volume: 60, Issue:1

    Topics: Adhesiveness; Animals; Bepridil; Calcium Channel Blockers; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Cytochalasin D; Cytochalasins; Electric Conductivity; Entamoeba histolytica; Female; Ovary; Pyrrolidines; Temperature; Verapamil

1985
The effects of some slow channel blocking drugs on high affinity serotonin uptake by rat brain synaptosomes.
    European journal of pharmacology, 1986, Apr-09, Volume: 123, Issue:1

    Topics: Animals; Bepridil; Brain; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyrrolidines; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Temperature; Time Factors; Verapamil

1986
A novel high affinity class of Ca2+ channel blockers.
    Molecular pharmacology, 1988, Volume: 33, Issue:4

    Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil

1988
Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (+/-)bepridil and (-)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes.
    Biochemical and biophysical research communications, 1985, Oct-15, Volume: 132, Issue:1

    Topics: Barium; Benzazepines; Bepridil; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Kinetics; Magnesium; Membranes; Microtubules; Muscles; Pyrrolidines; Receptors, Nicotinic; Strontium; Verapamil

1985
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
    The Journal of biological chemistry, 1986, Jan-25, Volume: 261, Issue:3

    Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil

1986
Role of sodium-calcium exchange and effects of calcium entry blockers on endothelial-mediated responses in rat isolated aorta.
    Molecular pharmacology, 1986, Volume: 30, Issue:1

    Topics: Amiloride; Animals; Aorta; Bepridil; Calcium; Calcium Channel Blockers; Choline; Cyclic GMP; Diltiazem; Endothelium; Female; Lithium; Muscle, Smooth, Vascular; Nicergoline; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Reserpine; Sodium; Verapamil

1986
Protective effects of the calmodulin antagonist bepridil on ischaemia induced in the rat myocardium.
    Cardiovascular research, 1986, Volume: 20, Issue:5

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Bepridil; Calmodulin; Coronary Disease; Drug Interactions; Male; Myocardial Contraction; Myocardium; Myosin-Light-Chain Kinase; Pyrrolidines; Rats; Rats, Inbred Strains; Uncoupling Agents; Verapamil

1986
Augmentation of succinylcholine-induced neuromuscular blockade by calcium channel antagonists.
    Neuroscience letters, 1986, Sep-25, Volume: 70, Issue:1

    Topics: Animals; Bepridil; Calcium Channel Blockers; Drug Synergism; In Vitro Techniques; Neuromuscular Junction; Nicardipine; Nifedipine; Pyrrolidines; Rana pipiens; Receptors, Nicotinic; Succinylcholine; Synaptic Transmission; Verapamil

1986
Effects of bepridil on regional myocardial ischemia and comparison with verapamil.
    The American journal of cardiology, 1986, Sep-01, Volume: 58, Issue:6

    Topics: Animals; Bepridil; Calcium Channel Blockers; Carbon Dioxide; Coronary Circulation; Coronary Disease; Dogs; Hydrogen-Ion Concentration; Myocardial Contraction; Myocardium; Pyrrolidines; Verapamil

1986
Stereoisomers of calcium antagonists discriminate between coronary vascular and myocardial sites.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 337, Issue:2

    Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Vessels; Gallopamil; Heart; In Vitro Techniques; Male; Pyrrolidines; Rats; Stereoisomerism; Verapamil

1988
[Pharmacology of calcium antagonists].
    La Revue du praticien, 1988, Nov-17, Volume: 38, Issue:27

    Topics: Bepridil; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Nifedipine; Pyrrolidines; Verapamil

1988
Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat.
    British journal of pharmacology, 1988, Volume: 95, Issue:3

    Topics: Animals; Bencyclane; Bepridil; Brain; Calcium Channel Blockers; Cinnarizine; Diltiazem; Electroencephalography; Fendiline; Flunarizine; Gallopamil; Heart Rate; Hypoxia; Nimodipine; Prenylamine; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration; Verapamil

1988
Effects of calcium blockers on ventricular fibrillation during acute myocardial infarction.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1988, Volume: 21, Issue:4

    Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Dogs; Myocardial Infarction; Myocardial Reperfusion; Pyrrolidines; Ventricular Fibrillation; Verapamil

1988
Effects of calcium channel blockers on sinoatrial conduction in the isolated and blood-perfused dog atrium.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 279, Issue:1

    Topics: Animals; Bepridil; Calcium Channel Blockers; Dilazep; Diltiazem; Dogs; Heart Rate; In Vitro Techniques; Isoindoles; Myocardial Contraction; Phthalimides; Pyrrolidines; Sinoatrial Node; Verapamil

1986
Protection of ischemic hearts by Ca2+ antagonists.
    Journal of molecular and cellular cardiology, 1986, Volume: 18 Suppl 4

    Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Energy Metabolism; Lactates; Lactic Acid; Mitochondria, Heart; Myocardial Contraction; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil

1986
Comparison of verapamil and bepridil, two slow channel inhibitors, in protection against calcium-induced arrhythmias.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Bepridil; Blood Pressure; Calcium; Electrocardiography; Heart Rate; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors; Verapamil

1986
Calcium antagonists and adenine nucleotide metabolism in rat heart.
    Cardiovascular research, 1986, Volume: 20, Issue:8

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Bepridil; Calcium Channel Blockers; Heart; Myocardium; Nifedipine; Nisoldipine; Pyrrolidines; Rats; Verapamil

1986
Comparative electrophysiologic effects of bepridil, verapamil and diltiazem in conscious and anesthetized dogs.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 284, Issue:1

    Topics: Anesthesia, General; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart Conduction System; Hemodynamics; Male; Pentobarbital; Pyrrolidines; Sinoatrial Node; Verapamil

1986
Comparative effects of bepridil, diltiazem, nifedipine and verapamil on haemodynamic parameters and myocardial oxygen consumption in anaesthetized dogs.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 284, Issue:2

    Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Female; Heart; Hemodynamics; Male; Myocardium; Nifedipine; Oxygen Consumption; Pyrrolidines; Vascular Resistance; Verapamil

1986
Effects of calcium entry blockers on blood pressure and heart rate in neurogenic hypertensive dogs.
    Fundamental & clinical pharmacology, 1987, Volume: 1, Issue:2

    Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Denervation; Diltiazem; Dogs; Female; Heart Rate; Hypertension; Male; Nicardipine; Nifedipine; Pyrrolidines; Sinoatrial Node; Verapamil

1987
Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil.
    Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:4

    Topics: Bepridil; Calcium Channel Blockers; Calmodulin; Cell Line; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; Ovarian Neoplasms; Pyrrolidines; Tumor Cells, Cultured; Verapamil

1987
Comparison of verapamil and bepridil in the therapy of familiar cardiomyopathy of the Syrian hamster.
    Zeitschrift fur Kardiologie, 1987, Volume: 76 Suppl 3

    Topics: Animals; Bepridil; Calcium; Cardiomyopathies; Cricetinae; Muscles; Necrosis; Osmolar Concentration; Pyrrolidines; Verapamil

1987
Calcium antagonists stimulate prostaglandin synthesis by cultured rat cardiac myocytes and prevent the effects of hypoxia.
    Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24

    Topics: Animals; Bepridil; Calcium Channel Blockers; Cells, Cultured; Cobalt; Diltiazem; Dinoprostone; Epoprostenol; Fibroblasts; Glycogen; Heart; Hypoxia; Myocardium; Prostaglandins E; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil

1986
Calcium channel blockers that prolong the QT interval.
    American heart journal, 1985, Volume: 109, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Dogs; Electrocardiography; Heart Atria; Heart Ventricles; Humans; Lidoflazine; Pyrrolidines; Quinidine; Systole; Verapamil

1985
Comparative electrophysiologic profiles of calcium antagonists with particular reference to bepridil.
    The American journal of cardiology, 1985, Mar-15, Volume: 55, Issue:7

    Topics: Adult; Aged; Arrhythmias, Cardiac; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Heart Conduction System; Humans; Male; Middle Aged; Pyrrolidines; Sinoatrial Node; Verapamil

1985
Pharmacology of calcium antagonists.
    The American journal of cardiology, 1985, Mar-15, Volume: 55, Issue:7

    Topics: Action Potentials; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Guinea Pigs; Heart; Heart Rate; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pyrrolidines; Rats; Vasodilation; Ventricular Fibrillation; Verapamil

1985
Electrophysiologic and antiarrhythmic properties of bepridil.
    The American journal of cardiology, 1985, Mar-15, Volume: 55, Issue:7

    Topics: Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Electrocardiography; Electrophysiology; Heart Conduction System; Heart Rate; Humans; Pyrrolidines; Tachycardia; Verapamil

1985
Electrophysiologic and antiarrhythmic actions of bepridil. Comparison with verapamil and ajmaline for atrioventricular reentrant tachycardia.
    The American journal of cardiology, 1985, Jun-01, Volume: 55, Issue:13 Pt 1

    Topics: Ajmaline; Anti-Arrhythmia Agents; Atrioventricular Node; Bepridil; Electrophysiology; Humans; Pyrrolidines; Tachycardia; Verapamil

1985
Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart.
    Cardiology, 1985, Volume: 72, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Bepridil; Constriction; Coronary Vessels; Dogs; Female; Heart Rate; Male; Pyrrolidines; Ventricular Fibrillation; Verapamil

1985
Properties of receptors for the Ca2+-channel blocker verapamil in transverse-tubule membranes of skeletal muscle. Stereospecificity, effect of Ca2+ and other inorganic cations, evidence for two categories of sites and effect of nucleoside triphosphates.
    European journal of biochemistry, 1984, Oct-15, Volume: 144, Issue:2

    Topics: Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channels; Cations, Divalent; Cations, Monovalent; Diltiazem; Electrochemistry; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Muscles; Nifedipine; Nitrendipine; Nucleotides; Pyrrolidines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil

1984
New directions in antiarrhythmic drug therapy.
    The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil

1984
Activation of the voltage-dependent Ca2+ channel in rat heart cells by dihydropyridine derivatives.
    Biochemical and biophysical research communications, 1984, Nov-30, Volume: 125, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bepridil; Calcium; Dose-Response Relationship, Drug; Ion Channels; Myocardium; Nifedipine; Pyridines; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors; Verapamil

1984
Effect of ion channel inhibitors on the cytopathogenicity of Entamoeba histolytica.
    The Journal of infectious diseases, 1982, Volume: 146, Issue:3

    Topics: Adhesiveness; Animals; Bepridil; Calcium; Cell Line; Cell Survival; Cricetinae; Entamoeba histolytica; Female; Ion Channels; Ovary; Pyrrolidines; Sodium; Tetrodotoxin; Verapamil

1982
The effect of bepridil, verapamil, and quinidine in the prevention of ventricular tachycardia induced by programmed electrical stimulation in the digitalized dog.
    American heart journal, 1984, Volume: 108, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Male; Pyrrolidines; Quinidine; Tachycardia; Verapamil

1984
Nifedipine, diltiazem, bepridil and verapamil uptakes into cardiac and smooth muscles.
    European journal of pharmacology, 1983, Feb-18, Volume: 87, Issue:2-3

    Topics: Animals; Benzazepines; Bepridil; Calcium Channel Blockers; Cats; Chick Embryo; Diltiazem; Ileum; In Vitro Techniques; Muscle, Smooth; Myocardium; Nifedipine; Papillary Muscles; Pyridines; Pyrrolidines; Rabbits; Time Factors; Verapamil

1983
Depression of contractions of rabbit aorta and guinea pig vena cava by mesudipine and other slow channel blockers.
    Blood vessels, 1983, Volume: 20, Issue:4

    Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium; Pyridines; Pyrrolidines; Rabbits; Vena Cava, Inferior; Verapamil

1983
Drinking water and drug dosage in rat studies.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Bepridil; Blood Pressure; Dose-Response Relationship, Drug; Drinking; Hydralazine; Hypertension; Indapamide; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil

1983
Ca2+-dependent slow action potentials in normal and dystrophic mouse skeletal muscle.
    The American journal of physiology, 1983, Volume: 245, Issue:5 Pt 1

    Topics: Action Potentials; Animals; Bepridil; Calcium; Glycerol; Kinetics; Lanthanum; Manganese; Mice; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal; Pyrrolidines; Uncoupling Agents; Verapamil

1983
Electromechanical effects of bepridil on rabbit isolated hearts.
    British journal of pharmacology, 1984, Volume: 81, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Bepridil; Bundle of His; Electric Stimulation; Electrophysiology; Heart; Heart Rate; In Vitro Techniques; Lidocaine; Pyrrolidines; Rabbits; Verapamil

1984
Uptake of calcium antagonistic drugs into muscles as related to their lipid solubilities.
    Biochemical pharmacology, 1984, Mar-01, Volume: 33, Issue:5

    Topics: Animals; Bepridil; Calcium Channel Blockers; Lipid Metabolism; Muscles; Nifedipine; Nitrendipine; Pyrrolidines; Rana pipiens; Rats; Sarcoplasmic Reticulum; Solubility; Verapamil

1984
Effects of five different organic calcium antagonists on guinea-pig isolated trachea.
    British journal of pharmacology, 1984, Volume: 82, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicardipine; Nifedipine; Pyrrolidines; Trachea; Verapamil

1984
Bepridil (CERM-1978) an verapamil depression of contractions of rabbit aortic rings.
    Blood vessels, 1981, Volume: 18, Issue:4-5

    Topics: Animals; Aorta; Bepridil; Calcium; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Pyrrolidines; Rabbits; Verapamil

1981
Effect of the calcium antagonists bepridil (CERM-1978) and verapamil on Ca++-dependent slow action potentials in frog skeletal muscle.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:1

    Topics: Action Potentials; Animals; Bepridil; Calcium; Calcium Channel Blockers; Glycerol; In Vitro Techniques; Microtubules; Muscles; Pyrrolidines; Rana pipiens; Verapamil

1982
Differential actions of calcium antagonists on calcium binding to cardiac sarcolemma.
    European journal of pharmacology, 1982, Jul-16, Volume: 81, Issue:3

    Topics: Animals; Bepridil; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Guinea Pigs; In Vitro Techniques; Myocardium; Nifedipine; Pyrrolidines; Sarcolemma; Verapamil

1982
Comparative effects of bepridil and verapamil on isolated coronary and systemic vascular and cardiac muscle.
    European journal of pharmacology, 1982, Dec-24, Volume: 86, Issue:2

    Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Chloride; Coronary Vessels; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Papillary Muscles; Potassium Chloride; Pyrrolidines; Rabbits; Swine; Verapamil

1982
Calcium-sensitivity of the plasmalemmal delayed rectifier potassium current suggests that calcium influx in pulvinar protoplasts from Mimosa pudica L. can be revealed by hyperpolarization.
    The Journal of membrane biology, 1995, Volume: 146, Issue:2

    Topics: Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Electric Conductivity; Ionomycin; Ionophores; Nitrendipine; Plant Physiological Phenomena; Potassium Channels; Protoplasts; Pulvinus; Verapamil

1995
Protective effect of some calcium antagonists against mitochondrial calcium injury.
    International journal of tissue reactions, 1994, Volume: 16, Issue:5-6

    Topics: Adenosine Triphosphate; Amlodipine; Animals; Antihypertensive Agents; Bepridil; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Mitochondria, Liver; Myocardial Ischemia; Nicardipine; Rats; Rats, Wistar; Verapamil

1994
Calcium channel antagonists induce direct inhibition of the outward rectifying potassium channel in tobacco protoplasts.
    FEBS letters, 1994, Feb-28, Volume: 340, Issue:1-2

    Topics: Bepridil; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; Membrane Potentials; Nicotiana; Nifedipine; Plants, Toxic; Potassium Channel Blockers; Protoplasts; Verapamil

1994
Bioequivalence revisited: non-parametric analysis of two-period cross-over studies.
    Computer methods and programs in biomedicine, 1993, Volume: 40, Issue:4

    Topics: Algorithms; Analysis of Variance; Angina Pectoris; Bepridil; Computer Simulation; Confidence Intervals; Delayed-Action Preparations; Double-Blind Method; Humans; Isosorbide Dinitrate; Male; Mathematical Computing; Reference Values; Software; Theophylline; Therapeutic Equivalency; Verapamil

1993
Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes.
    European journal of pharmacology, 1997, Aug-27, Volume: 333, Issue:2-3

    Topics: Animals; Benzofurans; Bepridil; Calcium; Calcium Channel Blockers; Cell Size; Cells, Cultured; Creatine Kinase; Dose-Response Relationship, Drug; Ethers, Cyclic; Flunarizine; Fura-2; Heart; Lysophosphatidylcholines; Male; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channels; Verapamil

1997
Twitch potentiation induced by caffeine in the mouse diaphragm depends on external calcium ions in the absence of potassium ions.
    General pharmacology, 1997, Volume: 29, Issue:5

    Topics: Animals; Bepridil; Caffeine; Calcium; Calcium Channel Blockers; Diaphragm; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Skeletal; Potassium; Verapamil

1997
HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers.
    Molecular pharmacology, 1998, Volume: 54, Issue:4

    Topics: Animals; Benzimidazoles; Bepridil; Calcium Channel Blockers; Cloning, Molecular; COS Cells; Heart; Ion Channel Gating; Long QT Syndrome; Membrane Potentials; Mibefradil; Potassium Channels; Tetrahydronaphthalenes; Transfection; Verapamil

1998
Prevention of apoptosis reperfusion renal injury by calcium channel blockers.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1999, Volume: 51, Issue:3

    Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Fendiline; Kidney; Kidney Tubules; Male; Nifedipine; Rats; Rats, Wistar; Reperfusion Injury; Severity of Illness Index; Time Factors; Verapamil

1999
p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:6

    Topics: Animals; Aorta, Thoracic; Bepridil; Berberine; Biological Transport, Active; Calcium; Calcium Channel Blockers; Female; Hyperthyroidism; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth, Vascular; Nimodipine; Rats; Rats, Sprague-Dawley; Thyroxine; Verapamil

1998
Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia.
    European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Creatine Kinase; Glyburide; Homeostasis; Hyperkalemia; Myocardium; Pinacidil; Potassium Channels; Potassium Chloride; Sodium-Calcium Exchanger; Verapamil

1999
Calcium channel blockers and mortality in elderly patients with myocardial infarction.
    Archives of internal medicine, 1999, Oct-25, Volume: 159, Issue:19

    Topics: Aged; Aged, 80 and over; Amlodipine; Bepridil; Calcium Channel Blockers; Diltiazem; Female; Humans; Logistic Models; Male; Myocardial Infarction; Nifedipine; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; United States; Verapamil

1999
[Compared study on Fura-2/AM assay and MTT assay for screening multidrug resistant modulators].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:6

    Topics: Bepridil; Breast Neoplasms; Calcium Channel Blockers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fura-2; Humans; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Verapamil

1997
Na(+)/Ca(2+) exchanger in porcine oocytes.
    Biology of reproduction, 2002, Volume: 67, Issue:4

    Topics: Amiloride; Animals; Base Sequence; Bepridil; Calcium; Calcium Channel Blockers; Cell Membrane; Cloning, Molecular; Enzyme Inhibitors; Female; Fluorescent Dyes; Fura-2; Immunohistochemistry; Molecular Sequence Data; Oocytes; Ouabain; Pimozide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Swine; Verapamil

2002
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
    European journal of pharmacology, 2004, Feb-20, Volume: 486, Issue:2

    Topics: Animals; Antipsychotic Agents; Bepridil; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cisapride; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Guinea Pigs; Heart Rate; Histamine H1 Antagonists; Humans; In Vitro Techniques; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Risperidone; Terfenadine; Verapamil

2004
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
    Journal of cardiovascular pharmacology, 2012, Volume: 60, Issue:2

    Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Ether-A-Go-Go Potassium Channels; Heart Conduction System; Humans; In Vitro Techniques; Long QT Syndrome; Piperidines; Potassium Channel Blockers; Pyridines; Risk Assessment; Risperidone; Time Factors; Torsades de Pointes; Toxicity Tests; Verapamil; Voltage-Sensitive Dye Imaging

2012
Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
    Scientific reports, 2015, Nov-30, Volume: 5

    Topics: Action Potentials; Animals; Bepridil; CHO Cells; Computer Simulation; Cricetulus; Ether-A-Go-Go Potassium Channels; Heart; HEK293 Cells; Humans; Inhibitory Concentration 50; Ion Channels; Membrane Potentials; Models, Biological; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperazines; Sulfonamides; Verapamil

2015
Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
    Human & experimental toxicology, 2018, Volume: 37, Issue:6

    Topics: Animals; Aorta, Thoracic; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Emulsions; In Vitro Techniques; Male; Nifedipine; Phenylephrine; Phospholipids; Rats; Rats, Sprague-Dawley; Soybean Oil; Vasodilation; Vasodilator Agents; Verapamil

2018
Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
    Toxicological sciences : an official journal of the Society of Toxicology, 2021, 04-27, Volume: 181, Issue:1

    Topics: Animals; Atrioventricular Block; Bepridil; Cisapride; Computer Simulation; Macaca fascicularis; Sotalol; Torsades de Pointes; Verapamil

2021
Association between hemorrhage and direct oral anticoagulants in combination with verapamil: Analysis of Japanese Adverse Drug Event Report database and electronic medical record data.
    International journal of clinical pharmacology and therapeutics, 2023, Volume: 61, Issue:4

    Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Anticoagulants; Atrial Fibrillation; Bepridil; Cohort Studies; East Asian People; Electronic Health Records; Hemorrhage; Humans; Verapamil

2023