bepafant has been researched along with 1-hexadecyl-2-acetyl-glycero-3-phosphocholine in 131 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 102 (77.86) | 18.2507 |
| 2000's | 26 (19.85) | 29.6817 |
| 2010's | 3 (2.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ono, S; Voelkel, NF | 2 |
| Ambruso, DR; Silliman, CC; Thurman, GW | 1 |
| Bienvenu, K; Granger, DN; Russell, J | 1 |
| Ono, S; Voelkel, NF; Westcott, JY | 1 |
| Faden, AI; Tzendzalian, PA | 1 |
| Heuer, HO; Muacevic, G | 1 |
| Levine, BA; McCollum, MO; Olson, MS; Zhou, W | 2 |
| Chao, W; Levine, BA; Olson, MS; Zhou, W | 1 |
| Creutzfeldt, W; Fayyazzi, A; Leonhardt, U; Seidensticker, F; Söling, HD; Stöckmann, F | 1 |
| Krantz, S; Lefer, AM; Ma, XL; Weyrich, AS | 1 |
| Faden, AI; Halt, P | 1 |
| Braillon, A; Cailmail, S; Champigneulle, B; Gaudin, C; Kleber, G; Lebrec, D | 1 |
| Amorim, CZ; Cordeiro, RS; Martins, MA; Vargaftig, BB | 1 |
| Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A | 1 |
| Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB | 1 |
| Chao, W; Levine, BA; Olson, MS; Zhou, WG | 1 |
| Anderson, BO; Banerjee, A; Bensard, DD; Harken, AH; Nelson, DW; Pitman, JM; Poggetti, RS; Shanley, PF; Whitman, GJ | 1 |
| Borst, HG; Fieguth, HG; Haverich, A; Hirt, SW; Jurmann, M; Wahlers, T | 1 |
| Gall, DG; MacNaughton, WK | 1 |
| Bureau, M; Dry, J; Lefort, J; Vargaftig, BB; Vincent, D | 1 |
| Heuer, HO | 4 |
| Klee, A; Schmid-Schönbein, GW; Seiffge, D | 1 |
| Becker, K; Förster, W; Lueddeckens, G; Rappold, R | 1 |
| Calne, RY; Collier, DG; DaCosta, M; Friend, PJ; Luddington, R; Metcalfe, SM; Pollard, SG; Watson, CJ | 1 |
| Heuer, HO; Keller, B; Urich, K | 1 |
| Gundel, RH; Letts, LG; Wegner, CD | 1 |
| Neugarten, J; Schlondorff, D; Yoo, J | 1 |
| Conklyn, M; Conyers, G; Cramer, E; Milks, L; Showell, H | 1 |
| Casals-Stenzel, J; Heuer, HO | 1 |
| Casals-Stenzel, J; Heuer, HO; Muacevic, G; Weber, KH | 1 |
| Cordeiro, RS; Fernandes, PD; Henriques, MG; Martins, MA; Silva, PM; Vargaftig, BB; Weg, VB | 1 |
| Calne, RY; Da Costa, M; Metcalfe, S | 1 |
| Exner, B; Leonhardt, U; Nebendahl, K; Ritzel, U; Schrock, E; Stöckmann, F | 1 |
| Bremer, C; Lang, H; Oldhafer, KJ; Pichlmayr, R; Schüttler, W; Spiegel, HU | 1 |
| Battaglia, E; Bussolino, F; Camussi, G; Emanuelli, G; Lupia, E; Montrucchio, G; Passerini, G | 1 |
| Chandel, B; Deshpande, Y; Kaminski, DL; Longo, WE; Niehoff, M; Polities, G; Robinson, S; Vernava, AM | 1 |
| Greenlees, C; Medhurst, AD; Parsons, AA; Smith, SJ | 1 |
| Biancone, L; Camussi, G; Duc, TM; Montrucchio, G; Ruikun, C; Silvestro, L; Sommer, F | 1 |
| Abdo, EE; Bonizzia, A; Coelho, AM; Jancar, S; Kwasniewski, FH; Machado, MC; Sampietre, SN | 1 |
| Aglietta, M; Arese, M; Barra, L; Benelli, R; Bussolino, F; Ghigo, D; Montrucchio, G; Primo, L; Rola-Pleszczynski, MR; Sanavio, F | 1 |
| Qin, X; Yu, P; Yuan, J | 1 |
| Appleyard, CB; Hillier, K | 1 |
| Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J | 1 |
| Hirafuji, M; Shinoda, H | 1 |
| Chandel, B; Deshpande, Y; Kaminski, DL; Kulkarni, A; Longo, WE; Niehoff, M; Polities, G; Vernava, AM | 1 |
| Das, A; Larkin, SW; Nourshargh, S; Williams, TJ | 1 |
| Brecht, HM; Haberstroh, U; Mihatsch, MJ; Oberle, G; Stahl, RA; Thaiss, F | 1 |
| Carter, JD; Chandel, B; Deshpande, Y; Kaminski, DL; Kulkarni, AD; Longo, WE; Niehoff, M; Polites, G; Standeven, J; Vernava, AM | 1 |
| Berthiaume, N; Bkaily, G; Claing, A; D'Orléans-Juste, P; Rola-Pleszczynski, M; Sirois, P | 1 |
| Cury, Y; Jancar, S; Oga, S; Teixeira, CF | 1 |
| Ashino, Y; Fujimura, S; Hoshikawa, Y; Nishimura, T; Noda, M; Ono, S; Tabata, S; Tanita, T; Ueda, S | 1 |
| Andrews, MJ; Cunningham, FM; Foster, AP; Lees, P | 1 |
| Alloatti, G; Camussi, G; Montrucchio, G | 1 |
| Calne, R; Chávez-Cartaya, RE; Jamieson, NV; Metcalfe, S; Ramirez-Romero, P | 1 |
| Calne, RY; Luddington, R; Metcalfe, SM; St John Collier, DG; Watson, CJ | 1 |
| Häyry, P; Mennander, A; Paavonen, T; Räisänen, A; Ustinov, J | 1 |
| De Brum-Fernandes, AJ; Fraga, CA; Jancar, S; Rocha, FA; Timo-Iaria, C | 1 |
| Abdulnour, E; Bkaily, G; d'Orléans-Juste, P; Naik, R; Pérodin, J; Rola-Pleszczynski, M; Stankova, J | 1 |
| Choy, PC; Hu, W; Man, RY; McNicholl, IK | 1 |
| Parent, JL; Stankova, J | 1 |
| Ambruso, DR; Clay, KL; Johnson, CA; Silliman, CC; Thurman, GW | 1 |
| Jung, TT; Miller, S; Rhee, CK; Weeks, D | 1 |
| Alloatti, G; Camussi, G; Emanuelli, G; Lucchina, PG; Lupia, E; Mariano, F; Montrucchio, G; Musso, E | 1 |
| Becker, K; Förster, W; Grupe, R; Lueddeckens, G | 1 |
| Alloatti, G; Cacace, G; Camussi, G; Comino, A; De Filippi, PG; Emanuelli, G; Mariano, F; Montrucchio, G; Polloni, R | 1 |
| Levine, BA; Olson, MS; Zhou, W | 1 |
| Amorim, CZ; Cordeiro, RS; Vargaftig, BB | 1 |
| Fu, W; Xiao, G; Yu, P | 2 |
| Lekka, M; Obladen, M; Scheid, A; Segerer, H; Wagner, MH | 1 |
| Frostegård, J; Huang, YH; Lorentzen, JC; Owman, H; Rönnelid, J; Schäfer-Elinder, L | 1 |
| Cacace, G; Camussi, G; De Filippi, PG; De Martino, A; Emanuelli, G; Lupia, E; Montrucchio, G; Savu, SR; Silvestro, L | 1 |
| Ferreira, MG; Fonteles, MC | 1 |
| Bussolino, F; Camussi, G; Comoglio, PM; Lupia, E; Montrucchio, G; Soldi, R | 1 |
| Adler, L; Caplan, MS; Hedlund, E; Hsueh, W; Lickerman, M | 1 |
| Frostegård, J; Huang, YH; Rönnelid, J; Schäfer-Elinder, L | 1 |
| Ammit, AJ; O'Neill, C | 1 |
| Arese, M; Battaglia, E; Bussolino, F; Camussi, G; de Martino, A; Lupia, E; Montrucchio, G; Tizzani, A | 1 |
| De Matos, IM; Freire-Maia, L; Leite, R; Rocha, OA | 1 |
| Freudenberg, J; Jocks, T; Stahl, RA; Zahner, G | 1 |
| Borman, RA; Hillier, K; Jewell, R | 1 |
| Baumann, G; Braun, M; Felix, SB; Hunger, T; Pietsch, P; Roediger, A | 1 |
| Hibler, S; Ibe, BO; Raj, JU | 1 |
| Jancar, S; Steil, AA; Tavares de Lima, W | 1 |
| Diefenbeck, M; Hammer, C; Linke, R; Seehofer, D | 1 |
| Biancone, L; Bussolati, B; Cambi, V; Camussi, G; David, S; Foà, R; Mariano, F | 1 |
| Baethmann, A; Pickelmann, S; Schürer, L; Uhl, E | 1 |
| Baethmann, A; Pickelmann, S; Röhrich, F; Schürer, L; Uhl, E | 1 |
| Battaglia, E; Brizzi, MF; Camussi, G; Del Sorbo, L; Dentelli, P; Garbarino, G; Montrucchio, G; Pegoraro, L | 1 |
| Chung, PS; Jeong, PS; Jung, TT; Kim, YH; Rhee, CK | 1 |
| Biancone, L; Bussolati, B; Camussi, G; Conaldi, PG; Del Sorbo, L; DeMartino, A; Toniolo, A | 1 |
| Bocheński, J; Chłopicki, S; Gryglewski, RJ | 1 |
| Alloatti, G; Camussi, G; De Martino, A; Montrucchio, G; Penna, C | 1 |
| Brizzi, MF; Camussi, G; Del Sorbo, L; Dentelli, P; Garbarino, G; Molinar, A; Pegoraro, L; Rosso, A | 1 |
| Flickinger, BD; Mustafa, SB; Olson, MS | 1 |
| Albini, A; Biancone, L; Boccellino, M; Bussolati, B; Camussi, G; Cantaluppi, V; Conaldi, PG; Del Sorbo, L; Toniolo, A | 1 |
| Chłopicki, S; Olszanecki, R | 1 |
| Battaglia, E; Biancone, L; Boccellino, M; Camussi, G; Del Sorbo, L; Emanuelli, G; Lupia, E; Montrucchio, G | 1 |
| Chang, H; De Plaen, IG; Hsueh, W; Remick, DG; Tan, XD; Wang, L | 1 |
| Caplan, M; Chang, H; Gonzalez-Crussi, F; Hsueh, W; Qu, XW; Tan, XD | 1 |
| Howard, KM; Olson, MS | 1 |
| Ahmed, A; Ahmed, Z; Dearn, S; Eggo, MC; Lewis, A; Rahman, M | 1 |
| Palmer, C; Roberts, RL; Viswanath, M | 1 |
| Barreiro, EJ; de Miranda, AL; Fraga, AG; Fraga, CA; Rodrigues, CR | 1 |
| Biancone, L; Bussolati, B; Camussi, G; Cassoni, P; Montrucchio, G; Rola-Pleszczynski, M; Russo, S | 1 |
| Alloatti, G; Camussi, G; Mariano, F; Penna, C | 1 |
| Arese, M; Biancone, L; Bussolino, F; Camussi, G; Del Sorbo, L; Giraudo, E; Tizzani, M | 1 |
| Bianchi, L; Cellai, C; Della Malva, N; Laurenzana, A; Paoletti, F; Vannucchi, AM | 1 |
| Carlson, SL; Hostettler, ME | 1 |
| Carlson, SL; Hostettler, ME; Knapp, PE | 1 |
| Biffl, WL; Carnaggio, R; Gonzalez, RJ; Moore, EE; Offner, PJ; Silliman, CC; West, KE | 1 |
| Bussolati, B; Camussi, G; Deambrosis, I; Mariano, F; Russo, S | 1 |
| Alloatti, G; Altruda, F; Azzolino, O; Barberis, L; Bedendi, I; Bosco, O; Del Sorbo, L; Hirsch, E; Levi, R; Malan, D; Marcantoni, A; Montrucchio, G; Penna, C; Wymann, M | 1 |
| Rhee, CK | 1 |
| Jung, TT; Park, SK; Rhee, CK | 1 |
| Al-Salti, W; Booth, IW; Coney, AM; Ewer, AK; Marshall, JM; Ramani, P | 1 |
| John, EO; Jung, TT; Park, SK; Park, YS; Rhee, CK | 1 |
| Chlopicki, S; Jakubowski, A; Olszanecki, R | 1 |
| Alloatti, G; Berta, G; Cappello, S; Gattullo, D; Losano, G; Mognetti, B; Pagliaro, P; Penna, C | 1 |
| De Plaen, IG; Ghosh, S; Han, XB; Hsueh, W; Liu, X; May, MJ | 1 |
| Calixto, JB; Kassuya, CA; Marotta, DM; Menezes-de-Lima, O; Rehder, VL; Silvestre, A | 1 |
| Jancar, S; Machado, MC; Molan, NA; Shio, MT; Souza, LJ | 1 |
| Abdallah, MF; Ibe, BO; Portugal, AM; Raj, JU | 1 |
| Abdel-Al, M; Ditmyer, M; Howard, KM; Patel, N | 1 |
| Arteaga, A; Bae, R; Ibe, BO; Raj, JU | 1 |
| Demopoulos, CA; Papakyriakou, A; Philippopoulos, AI; Tsoupras, AB | 1 |
2 review(s) available for bepafant and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine
| Article | Year |
|---|---|
The effects of hetrazepine PAF antagonists in preclinical models of asthma.
Topics: Anaphylaxis; Animals; Antigens; Asthma; Azepines; Blood Platelets; Bronchi; Bronchoconstriction; Capillary Permeability; Cell Movement; Eosinophils; Lung; Platelet Activating Factor; Respiratory Hypersensitivity; Triazoles | 1991 |
Involvement of platelet-activating factor (PAF) in septic shock and priming as indicated by the effect of hetrazepinoic PAF antagonists.
Topics: Animals; Azepines; Endotoxins; Humans; Models, Biological; Multiple Organ Failure; Platelet Activating Factor; Shock, Septic; Triazoles | 1991 |
129 other study(ies) available for bepafant and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine
| Article | Year |
|---|---|
PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.
Topics: Animals; Azepines; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Artery; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thymidine; Triazoles | 1992 |
Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor.
Topics: Azepines; Blood Platelets; Enzyme Activation; Erythrocytes; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1992 |
Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules.
Topics: Animals; Antigens, CD; Azepines; Benzopyrans; Cats; CD18 Antigens; Endothelium, Vascular; Indoles; Leukocytes; Leukotriene B4; Mesenteric Veins; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Triazoles; Venules | 1992 |
PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats.
Topics: Animals; Azepines; Endothelins; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Circulation; Rats; Triazoles; Vasoconstriction | 1992 |
Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma.
Topics: Animals; Azepines; Behavior, Animal; Body Water; Brain; Brain Injuries; Cations; Dialysis; Diterpenes; Ginkgolides; Glycine; Lactones; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
Platelet-activating factor antagonists in experimental shock.
Topics: Acid-Base Equilibrium; Animals; Azepines; Blood Pressure; Electrocardiography; Endotoxins; Hyperkalemia; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Shock; Triazoles | 1992 |
Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion.
Topics: Alanine Transaminase; Allopurinol; Animals; Azepines; Gadolinium; Hepatitis; Ischemia; Leukocytes; Liver; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles | 1992 |
Role of platelet-activating factor in hepatic responses after bile duct ligation in rats.
Topics: Animals; Azepines; Bile Ducts; Cholestasis; Diterpenes; Endotoxins; Ginkgolides; Kupffer Cells; Lactones; Ligation; Lipopolysaccharides; Liver; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1992 |
Influence of a platelet-activating factor antagonist on severe pancreatitis in two experimental models.
Topics: Animals; Ascites; Azepines; Male; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar; Survival Rate; Triazoles | 1992 |
Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion.
Topics: Animals; Azepines; Cats; Cell Adhesion; Coronary Disease; Creatine Kinase; Endothelium, Vascular; Heart; Hemodynamics; Male; Myocardial Reperfusion Injury; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1992 |
Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat.
Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Diterpenes; Eicosanoids; Enzymes; Ginkgolides; Lactones; Lung; Pancreatitis; Platelet Activating Factor; Rats; Triazoles | 1992 |
Platelet-activating factor reduces spinal cord blood flow and causes behavioral deficits after intrathecal administration in rats through a specific receptor mechanism.
Topics: Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Injections, Spinal; Male; Motor Activity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Spinal Cord; Triazoles | 1992 |
Hemodynamic effects of endotoxin and platelet activating factor in cirrhotic rats.
Topics: Animals; Azepines; Blood Pressure; Diterpenes; Endotoxins; Ginkgolides; Heart Rate; Hemodynamics; Lactones; Liver Cirrhosis, Experimental; Male; Platelet Activating Factor; Portal System; Rats; Rats, Inbred Strains; Triazoles | 1992 |
Differential inhibition by the PAF receptor antagonist, WEB 2170, of allergic inflammation in single sensitized and boosted mice.
Topics: Animals; Antigens; Azepines; Dose-Response Relationship, Drug; Edema; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Triazoles | 1992 |
Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Azepines; Clemastine; Coronary Disease; Coronary Vessels; Guinea Pigs; Organoselenium Compounds; Ouabain; Piperidines; Platelet Activating Factor; Propranolol; Rats; Triazoles; Umbelliferones; Ventricular Fibrillation | 1992 |
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; Aspirin; Azepines; Cimetidine; Dexamethasone; Edema; Male; Meclizine; Methysergide; Mice; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Triazoles | 1991 |
Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.
Topics: Amylases; Animals; Azepines; Chronic Disease; Diterpenes; Ginkgolides; Lactones; Ligation; Male; Pancreas; Pancreatic Ducts; Pancreatitis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Time Factors; Triazoles | 1990 |
Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism.
Topics: Animals; Azepines; Lipopolysaccharides; Lung; Lung Diseases; Male; Neutrophils; Nitroblue Tetrazolium; Oligopeptides; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; Staining and Labeling; Triazoles | 1991 |
Future horizons of lung preservation by application of a platelet-activating factor antagonist compared with current clinical standards. Euro-Collins flush perfusion versus donor core cooling.
Topics: Animals; Azepines; Cold Temperature; Dogs; Epoprostenol; Heart-Lung Transplantation; Hemodynamics; Hypertonic Solutions; Organ Preservation; Oxygen; Platelet Activating Factor; Pulmonary Circulation; Triazoles | 1992 |
Mechanisms of platelet-activating factor-induced electrolyte transport in the rat jejunum.
Topics: Animals; Arachidonic Acids; Azepines; Biological Transport, Active; Chlorides; Dinoprostone; Eicosanoic Acids; Electrophysiology; Female; Indomethacin; Jejunum; Platelet Activating Factor; Quinacrine; Rats; Triazoles | 1991 |
Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig.
Topics: Animals; Aspirin; Azepines; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Escherichia coli; Guinea Pigs; Lipopolysaccharides; Macrophages; Male; Neutrophils; Platelet Activating Factor; Pulmonary Edema; Pyrilamine; Respiratory Hypersensitivity; Triazoles | 1991 |
Effects of platelet activating factor on rat platelets in vivo.
Topics: Adenosine Diphosphate; Animals; Azepines; Blood Platelets; In Vitro Techniques; Leukocytes; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Count; Pulmonary Embolism; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction.
Topics: Aminophylline; Animals; Azepines; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Diterpenes; Endothelins; Ginkgolides; Guinea Pigs; Ketotifen; Lactones; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Platelet Activating Factor; Platelet Aggregation Inhibitors; Theophylline; Thromboxane B2; Triazoles; Umbelliferones; Vasoconstriction; Vasoconstrictor Agents | 1991 |
Effect of the hetrazepinoic platelet-activating factor antagonist Bepafant (WEB 2170) in models of active and passive anaphylaxis in mice and guinea pigs.
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Lung; Male; Mice; Mice, Inbred Strains; Ovalbumin; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Propranolol; Pyrilamine; Respiration; Triazoles | 1991 |
PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.
Topics: Animals; Azepines; Cardiomegaly; Hypertension, Pulmonary; Lung; Lung Injury; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Survival of renal allografted dogs after limited therapy with cyclosporine and the PAF antagonist WEB 2170.
Topics: Animals; Azepines; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Platelet Activating Factor; Triazoles | 1991 |
Action of the racemate and the isomers of the platelet-activating factor antagonist bepafant (WEB 2170) after oral administration to guinea-pigs and rats.
Topics: Administration, Oral; Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Male; Platelet Activating Factor; Pulmonary Ventilation; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Time Factors; Triazoles | 1991 |
The role of platelet activating factor in airway inflammation, airway hyperresponsiveness, and pulmonary function in monkeys.
Topics: Aerosols; Animals; Antigens; Azepines; Bronchoconstriction; Lung; Macaca fascicularis; Male; Methacholine Chloride; Neutrophils; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles | 1991 |
Inhibition of active anaphylaxis in mice and guinea pigs by the new hetrazepinoic PAF antagonist bepafant (WEB 2170).
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchoconstriction; Guinea Pigs; Immunization; Male; Mice; Ovalbumin; Platelet Activating Factor; Propranolol; Pulmonary Ventilation; Pyrilamine; Triazoles | 1991 |
Protective effects of specific platelet-activating factor receptor antagonists in experimental glomerulonephritis.
Topics: Animals; Azepines; Glomerular Filtration Rate; Glomerulonephritis; Hemodynamics; Kidney; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
A factor in serum lowers resistance and opens tight junctions of MDCK cells.
Topics: Animals; Azepines; Blood; Cell Line; Chromatography, Gel; Complement C3a; Complement C5a; Culture Media; Dogs; Humans; Inflammation; Intercellular Junctions; Kidney; Kinetics; Molecular Weight; Platelet Activating Factor; Serum Albumin; Triazoles | 1990 |
Use of WEB 2086 and WEB 2170 as platelet-activating factor antagonists.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Lung; Methods; Molecular Structure; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits; Triazoles | 1990 |
Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor.
Topics: Administration, Oral; Animals; Azepines; Bronchoconstriction; Capillary Permeability; Cell Aggregation; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypotension; Infusions, Intravenous; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Skin; Time Factors; Triazoles | 1990 |
Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Carrageenan; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Female; Leukocyte Count; Male; Mice; Platelet Activating Factor; Pleurisy; Serotonin; Triazines; Triazoles | 1990 |
Prolongation of rat heart allograft survival using low-dose cyclosporine and PAF antagonist WEB 2170.
Topics: Animals; Azepines; Cyclosporins; Graft Rejection; Graft Survival; Heart Transplantation; Platelet Activating Factor; Rats; Transplantation, Heterotopic; Transplantation, Homologous; Triazoles | 1990 |
Effect of a platelet-activating factor antagonist on pancreas perfusion after 24 h of ischemia.
Topics: Animals; Azepines; Cold Temperature; Ischemia; Pancreas; Platelet Activating Factor; Reperfusion; Swine; Tissue Preservation; Triazoles | 1995 |
Beneficial effect of the platelet-activating factor antagonist WEB 2170 on reperfusion injury after orthotopic liver transplantation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azepines; Bilirubin; Body Weight; Graft Survival; Liver; Liver Function Tests; Liver Transplantation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Reperfusion Injury; Swine; Time Factors; Triazoles | 1995 |
Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.
Topics: Animals; Azepines; Collagen; Drug Combinations; Female; Laminin; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Platelet Activating Factor; Proteoglycans; Triazoles; Tumor Necrosis Factor-alpha | 1994 |
Effect of platelet-activating factor and its antagonists on colonic dysmotility and tissue levels of colonic neuropeptides.
Topics: Alprazolam; Animals; Azepines; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Iodine Radioisotopes; Neuropeptides; Platelet Activating Factor; Rabbits; Substance P; Triazoles; Vasoactive Intestinal Peptide | 1994 |
Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro.
Topics: Alprazolam; Animals; Azepines; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Iodine Radioisotopes; Neuropeptides; Platelet Activating Factor; Rabbits; Substance P; Triazoles; Vasoactive Intestinal Peptide | 1994 |
Platelet-activating factor-induced endothelial cell expression of adhesion molecules and modulation of surface glycocalyx, evaluated by electron spectroscopy chemical analysis.
Topics: Antibodies, Monoclonal; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cycloheximide; Electron Probe Microanalysis; Endothelium, Vascular; Fluorescent Antibody Technique; Gene Expression Regulation; Glycoproteins; Humans; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polysaccharides; Proteoglycans; Triazoles; Umbilical Veins | 1994 |
Effect of PAF antagonists on cerulein-induced pancreatitis.
Topics: Acute Disease; Amylases; Animals; Azepines; Capillary Permeability; Ceruletide; Diterpenes; Evans Blue; Ginkgolides; Lactones; Male; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1995 |
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.
Topics: Aged; Animals; Azepines; Base Sequence; Cell Line; Chemotaxis; Choriocarcinoma; Collagen; Culture Media, Conditioned; Cytokines; Dogs; Drug Combinations; Endothelium, Vascular; Female; Growth Substances; Humans; Interleukin-1; Laminin; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Proteins; Neovascularization, Pathologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; Skin Neoplasms; Thrombin; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins; Uterine Neoplasms | 1995 |
[The effect of platelet-activating factor antagonists on early bacteria translocation of rat after burn injury].
Topics: Animals; Azepines; Bacterial Translocation; Burns; Escherichia coli; Escherichia coli Infections; Platelet Activating Factor; Random Allocation; Rats; Rats, Wistar; Triazoles | 1995 |
Biosynthesis of platelet-activating factor in normal and inflamed human colon mucosa: evidence for the involvement of the pathway of platelet-activating factor synthesis de novo in inflammatory bowel disease.
Topics: Aged; Azepines; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colon; Culture Techniques; Cytidine Diphosphate Choline; Female; Glyceryl Ethers; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Platelet Activating Factor; Triazoles | 1995 |
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
Topics: Animals; Azepines; Benzodiazepines; Imidazoles; Mice; Platelet Activating Factor; Pyridines; Rabbits; Structure-Activity Relationship; Thiazoles; Triazoles | 1995 |
Increased prostaglandin I2 and thromboxane A2 production by rat dental pulp after intravenous administration of endotoxin.
Topics: Animals; Arachidonic Acid; Azepines; Dental Pulp; Endotoxins; Epoprostenol; Escherichia coli; Indomethacin; Injections, Intravenous; Jejunum; Lung; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane A2; Time Factors; Triazoles | 1994 |
Platelet-activating factor mediates trinitrobenzene induced colitis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Colitis; Colon; Dinoprostone; Eicosanoids; Gastrointestinal Contents; Leukotriene B4; Platelet Activating Factor; Rabbits; Second Messenger Systems; Thromboxane B2; Triazoles; Trinitrobenzenesulfonic Acid | 1994 |
Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor.
Topics: Animals; Azepines; Cell Adhesion; Chemotaxis, Leukocyte; Dihydropyridines; Edema; Imidazoles; Inflammation; Interleukin-1; Leukocytes; Male; Mesentery; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Skin; Triazoles | 1995 |
Platelet-activating factor receptor antagonist improves renal function and glomerular lesions in renal ablation.
Topics: Albuminuria; Animals; Azepines; Blood Pressure; Body Weight; Eicosanoids; Inulin; Kidney; Kidney Glomerulus; Male; Nephrectomy; Organ Size; p-Aminohippuric Acid; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1994 |
Evidence for a colonic PAF receptor.
Topics: Animals; Azepines; Colon; Eicosanoids; In Vitro Techniques; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1995 |
Role of R-type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet-activating factor.
Topics: Animals; Arginine; Azepines; Calcium Channels; Isradipine; Male; Mesenteric Arteries; Mesenteric Veins; NG-Nitroarginine Methyl Ester; Perfusion; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Wistar; Triazoles | 1994 |
Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF).
Topics: Animals; Azepines; Bothrops; Crotalid Venoms; Dexamethasone; Diterpenes; Dose-Response Relationship, Drug; Eicosanoids; Fibrinolytic Agents; Ginkgolides; Hyperalgesia; Indomethacin; Lactones; Male; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles | 1994 |
[Lung 3H-thymidine incorporation in monocrotaline (MCT)-treated rats--role of platelet-activating factor (PAF)].
Topics: Animals; Azepines; DNA; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thymidine; Triazoles | 1994 |
A comparison of the actions of platelet activating factor (PAF) antagonists WEB 2170 and WEB 2086 in the horse.
Topics: Animals; Azepines; Capillary Permeability; Dose-Response Relationship, Drug; Histamine; Horses; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Skin; Triazoles | 1993 |
Role of platelet-activating factor (PAF) in oxygen radical-induced cardiac dysfunction.
Topics: Animals; Azepines; Free Radicals; Fumarates; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Platelet Activating Factor; Reactive Oxygen Species; Superoxide Dismutase; Triazoles | 1994 |
Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes.
Topics: Animals; Azepines; Liver; Liver Circulation; Male; Neutrophils; Oxyhemoglobins; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Triazoles; Vinblastine | 1994 |
The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival.
Topics: Animals; Azepines; Cyclosporine; Dogs; Drug Therapy, Combination; Graft Survival; Immunosuppression Therapy; Kidney Transplantation; Platelet Activating Factor; Survival Analysis; Transplantation, Homologous; Triazoles | 1993 |
Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Autoradiography; Azepines; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Fibroblasts; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred WF; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Transplantation, Homologous; Triazoles | 1993 |
Platelet activating factor and histamine effects in synovial blood flow evaluated by laser-Doppler flowmetry.
Topics: Animals; Azepines; Female; Histamine; Laser-Doppler Flowmetry; Male; Platelet Activating Factor; Rabbits; Regional Blood Flow; Synovial Membrane; Triazoles; Vasoconstriction | 1993 |
PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells.
Topics: Azepines; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Endothelium, Vascular; Fura-2; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Ion Channel Gating; Isradipine; Male; Platelet Activating Factor; Potassium; Triazoles | 1993 |
Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart.
Topics: Animals; Azepines; Heart; In Vitro Techniques; Leukotrienes; Perfusion; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction; Vasodilation | 1993 |
Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines.
Topics: Azepines; B-Lymphocytes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Gene Expression; Humans; Ionomycin; Kinetics; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Triazoles; Tumor Cells, Cultured; Up-Regulation | 1993 |
Compounds biologically similar to platelet activating factor are present in stored blood components.
Topics: Azepines; Blood Preservation; Gas Chromatography-Mass Spectrometry; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Radioimmunoassay; Triazoles | 1993 |
Experimental otitis media with effusion induced by platelet activating factor.
Topics: Animals; Azepines; Chinchilla; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Otitis Media with Effusion; Platelet Activating Factor; Temporal Bone; Time Factors; Triazoles | 1993 |
Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.
Topics: Animals; Azepines; Female; Hypotension; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Quinolines; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptokinase; Tissue Plasminogen Activator; Triazoles | 1993 |
PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Disease Models, Animal; Diterpenes; Eicosanoids; Female; Ginkgolides; Lactones; Masoprocol; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock; Species Specificity; Triazoles | 1993 |
Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart.
Topics: Animals; Azepines; Cell Movement; Female; Heart; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Platelet Activating Factor; Quinolines; Rabbits; Risk Factors; Triazoles | 1993 |
Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation.
Topics: Animals; Azepines; Calcium; Ceruletide; Male; Osmolar Concentration; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles | 1993 |
Involvement of platelet-activating factor in death following anaphylactic shock in boosted and in unboosted mice.
Topics: Anaphylaxis; Animals; Azepines; Immunization, Secondary; Immunoglobulin E; Immunoglobulin G; Male; Mice; Ovalbumin; Platelet Activating Factor; Triazoles; Vaccination | 1993 |
[The roles of platelet activating factor in intestinal mucosal barrier injury after burn].
Topics: Animals; Azepines; Burns; Female; Intestinal Mucosa; Male; Membrane Potentials; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 1995 |
Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution.
Topics: Animals; Azepines; Blood Pressure; Lung; Oxygen; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Surface-Active Agents; Tissue Distribution; Trachea; Triazoles | 1996 |
Induction of IL-4 by platelet-activating factor.
Topics: Antibodies, Monoclonal; Azepines; Cells, Cultured; Histocompatibility Antigens Class II; Humans; Immunoglobulin A; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lymphocyte Activation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1996 |
Plasmin promotes an endothelium-dependent adhesion of neutrophils. Involvement of platelet activating factor and P-selectin.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Azepines; Capillary Permeability; Cattle; CD18 Antigens; Cell Adhesion; Endothelium, Vascular; Fibrinolysin; Humans; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptokinase; Tissue Plasminogen Activator; Triazoles | 1996 |
Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.
Topics: Animals; Azepines; Dihydropyridines; Ginkgolides; In Vitro Techniques; Kidney; Lactones; Norepinephrine; Platelet Activating Factor; Rabbits; Tachyphylaxis; Triazoles; Vasoconstriction | 1996 |
Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages.
Topics: Animals; Azepines; Cattle; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Collagen; Drug Combinations; Hepatocyte Growth Factor; Humans; Laminin; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phosphotyrosine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 1997 |
The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats.
Topics: Animals; Animals, Newborn; Azepines; Enterocolitis, Pseudomembranous; Intestinal Mucosa; Intestine, Small; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1997 |
Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism.
Topics: Azepines; Humans; Immunity; Interferon-gamma; Leukocytes, Mononuclear; Lipoproteins, LDL; Oxidation-Reduction; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Necrosis Factor-alpha | 1997 |
Studies of the nature of the binding by albumin of platelet-activating factor released from cells.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Biological Availability; Blastocyst; Calcimycin; Cattle; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Ionophores; Mice; Pepsin A; Peptide Mapping; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Binding; Protein Conformation; Serum Albumin; Serum Albumin, Bovine; Sulfhydryl Reagents; Triazoles; Trypsin | 1997 |
Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.
Topics: Animals; Azepines; Cell Movement; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Triazoles; Tumor Necrosis Factor-alpha | 1997 |
[A study on changes and its mechanisms of intestinal mucosal permeability after severe burn].
Topics: Animals; Azepines; Burns; Female; Intestinal Mucosa; Male; Permeability; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Technetium Tc 99m Pentetate; Triazoles | 1996 |
Lung oedema induced by Tityus serrulatus scorpion venom in the rat.
Topics: Animals; Aprotinin; Azepines; Capillary Permeability; Cyclooxygenase Inhibitors; Diterpenes; Drug Interactions; Fibrinolytic Agents; Ginkgolides; Hemostatics; Heparin; Hypertension; Injections, Intravenous; Lactones; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandins; Pulmonary Edema; Rats; Rats, Wistar; Scorpion Venoms; Triazoles | 1997 |
Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury.
Topics: Animals; Azepines; Chemokine CCL2; Complement System Proteins; Glomerulonephritis; Kidney Glomerulus; Male; Platelet Activating Factor; Polymerase Chain Reaction; Rabbits; Rats; Rats, Wistar; RNA, Messenger; Triazoles | 1998 |
Investigation of the effects of platelet-activating factor (PAF) on ion transport and prostaglandin synthesis in human colonic mucosa in vitro.
Topics: Azepines; Biological Transport; Colon; Humans; Intestinal Mucosa; Ions; Membrane Potentials; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1998 |
Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes.
Topics: Analysis of Variance; Animals; Azepines; Calcium; Male; Myocardial Contraction; Myocardium; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 1998 |
Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb.
Topics: Angiotensin II; Animals; Animals, Newborn; Azepines; Blood Pressure; Female; Muscle Tonus; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pregnancy; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sheep; Triazoles; Vascular Resistance; Vasoconstrictor Agents | 1998 |
Modulation by lipid mediators of immune complex-induced lung inflammation in mice.
Topics: Animals; Antigen-Antibody Complex; Arthus Reaction; Azepines; Benzopyrans; Blood Vessels; Bronchoalveolar Lavage Fluid; Capillary Permeability; Dose-Response Relationship, Drug; Eicosanoids; Hemoglobins; Immune Complex Diseases; Indoles; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pneumonia; Receptors, Leukotriene B4; Species Specificity; Triazoles | 1998 |
Xenogeneic rejection mechanisms shown by intravital microscopy.
Topics: Animals; Azepines; Bile; Blood Pressure; Blood Transfusion; Elapid Venoms; Graft Rejection; Humans; Liver Circulation; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous; Transplantation, Isogeneic; Triazoles | 1998 |
Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change.
Topics: Angiotensin II; Azepines; Cell Size; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Interleukin-12; Interleukin-8; Lipopolysaccharides; Platelet Activating Factor; Platelet Aggregation Inhibitors; Receptors, Interleukin; Receptors, Interleukin-12; RNA, Messenger; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application.
Topics: Animals; Azepines; Blood Pressure; Blood-Brain Barrier; Carbon Dioxide; Cell Communication; Cerebrovascular Circulation; Endothelium, Vascular; Hematocrit; Hydrogen-Ion Concentration; Leukocyte Count; Leukocytes; Male; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application.
Topics: Animals; Azepines; Blood Pressure; Blood-Brain Barrier; Cell Communication; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Leukocytes; Male; Microcirculation; Microscopy, Fluorescence; Pia Mater; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism.
Topics: Animals; Azepines; Biocompatible Materials; Biological Transport; Cell Division; Cell Movement; Cell Nucleus; Cells, Cultured; Collagen; DNA-Binding Proteins; Drug Combinations; Endothelium, Vascular; Fibroblast Growth Factor 2; Gene Expression; Humans; Interleukin-8; Kinetics; Laminin; Mice; Milk Proteins; Neoplasm Proteins; Neovascularization, Physiologic; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Proteoglycans; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Thrombopoietin; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Triazoles; Tyrosine; Umbilical Veins | 1999 |
Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs.
Topics: Animals; Azepines; Cilia; Coloring Agents; Dose-Response Relationship, Drug; Epithelium; Eustachian Tube; Guinea Pigs; Microscopy, Electron; Mucociliary Clearance; Otitis Media with Effusion; Platelet Activating Factor; Rosaniline Dyes; Triazoles | 1999 |
The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat.
Topics: Azepines; Chemotaxis; Gene Products, tat; HIV-1; Humans; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 1999 |
Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats.
Topics: Animals; Azepines; Blood Pressure; Enzyme Inhibitors; Escherichia coli; Indans; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxane A2; Triazoles | 1999 |
Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle.
Topics: Action Potentials; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Azepines; Cyclooxygenase Inhibitors; Depression, Chemical; Guinea Pigs; Heart; In Vitro Techniques; Indomethacin; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Propranolol; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation.
Topics: Animals; Apolipoproteins; Apolipoproteins D; Azepines; Carrier Proteins; Cell Division; Cell Line; Cell Movement; DNA-Binding Proteins; Endothelium, Vascular; Female; Glycoproteins; Humans; Injections, Subcutaneous; Interleukin-3; Macromolecular Substances; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Milk Proteins; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Interleukin-3; STAT5 Transcription Factor; Trans-Activators; Triazoles; Tumor Suppressor Proteins | 1999 |
Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells.
Topics: Alanine Transaminase; Animals; Azepines; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Endotoxemia; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Kupffer Cells; Lipopolysaccharides; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Triazoles | 1999 |
Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis.
Topics: Azepines; Cell Movement; Diterpenes; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Products, tat; Ginkgolides; HIV-1; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; tat Gene Products, Human Immunodeficiency Virus; Triazoles; Tumor Cells, Cultured | 1999 |
Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia.
Topics: Animals; Azepines; Cell Movement; Endotoxemia; Indans; Lactic Acid; Lipopolysaccharides; Lung; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane A2; Triazoles | 1999 |
Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model.
Topics: Animals; Azepines; Cell Movement; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Lymphokines; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor.
Topics: Animals; Antibodies, Blocking; Azepines; Cell Nucleus; Electrophoresis; Epithelial Cells; Ileum; Immunohistochemistry; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Neutrophils; NF-kappa B; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin.
Topics: Animals; Azepines; Cadherins; Cytoskeleton; Dextrans; Enzyme Inhibitors; Epithelium; Glucose; Hypotension; Intestinal Mucosa; Intestines; Leukocytosis; Male; Permeability; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Tyrosine; Tyrphostins | 2000 |
The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; DNA, Complementary; Endotoxemia; Endotoxins; Kupffer Cells; Leukocytes; Lipopolysaccharides; Liver; Macrophages, Peritoneal; Male; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride; Tissue Distribution; Triazoles; Up-Regulation | 2000 |
Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line.
Topics: Azepines; Calcium; Cell Line; Endometrium; Enzyme Activation; Epithelial Cells; Female; Humans; Indoles; Infertility, Female; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase C-alpha; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2000 |
Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection.
Topics: Animals; Animals, Newborn; Atrophy; Azepines; Brain; Brain Edema; Female; Hypoxia-Ischemia, Brain; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles; Weight Gain | 2000 |
Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists.
Topics: Animals; Azepines; Models, Molecular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Triazoles | 2000 |
PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.
Topics: Animals; Azepines; Breast Neoplasms; Cell Division; Cell Movement; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured | 2000 |
Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha.
Topics: Animals; Azepines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Phospholipases A; Platelet Activating Factor; S-Nitroso-N-Acetylpenicillamine; Stereoisomerism; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat.
Topics: Angiogenesis Inducing Agents; Animals; Azepines; Cell Movement; Endothelium, Vascular; Female; Gene Products, tat; HIV-1; Humans; Mice; Mice, Inbred C57BL; Platelet Activating Factor; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 2001 |
Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; HL-60 Cells; Humans; K562 Cells; Kinetics; Leukemia; Leukemia, Erythroblastic, Acute; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Triazoles; Tumor Cells, Cultured | 2002 |
PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury.
Topics: Animals; Azepines; Cytokines; Female; Inflammation Mediators; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord Injuries; Thoracic Vertebrae; Time Factors; Triazoles | 2002 |
Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3.
Topics: Animals; Animals, Newborn; Antigens, Differentiation; Astrocytes; Azepines; Caspase 3; Caspases; Cell Death; Cells, Cultured; Central Nervous System; Diterpenes; Dose-Response Relationship, Drug; Free Radical Scavengers; Ginkgolides; Glial Fibrillary Acidic Protein; Inflammation; Lactones; Mice; Mice, Inbred CBA; Oligodendroglia; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Spinal Cord Injuries; Triazoles | 2002 |
Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
Topics: Adolescent; Adult; Aged; Apoptosis; Azepines; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Injury Severity Score; Maleimides; Middle Aged; Neutrophils; Phospholipids; Plasma; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Signal Transduction; Time Factors; Triazoles; Wounds and Injuries | 2001 |
Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction.
Topics: Animals; Antibodies, Monoclonal; Azepines; CD40 Antigens; CD40 Ligand; Cell Communication; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Female; Humans; Injections, Subcutaneous; Intracellular Fluid; Laminin; Mice; Mice, Inbred C57BL; Models, Immunological; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, G-Protein-Coupled; Triazoles | 2003 |
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.
Topics: Animals; Azepines; Class Ib Phosphatidylinositol 3-Kinase; Female; In Vitro Techniques; Isoenzymes; Mice; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2003 |
Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide?
Topics: Animals; Azepines; Cochlea; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Immunohistochemistry; Longitudinal Studies; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Random Allocation; Round Window, Ear; Triazoles | 2003 |
Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion.
Topics: Animals; Arachidonic Acid; Azepines; Case-Control Studies; Chinchilla; Chromatography, High Pressure Liquid; Haemophilus influenzae; Injections, Intraperitoneal; Leukotriene Antagonists; Leukotrienes; Naphthyridines; Otitis Media with Effusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Temporal Bone; Triazoles | 2004 |
The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis.
Topics: Animals; Animals, Newborn; Azepines; Blood Gas Analysis; Blood Pressure; Enterocolitis, Necrotizing; Hypoxia; Intestinal Mucosa; Lipopolysaccharides; Mesenteric Arteries; Models, Animal; Platelet Activating Factor; Regional Blood Flow; Swine; Triazoles; Vascular Resistance | 2004 |
Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells.
Topics: Albumins; Animals; Azepines; Chinchilla; Hair Cells, Auditory, Outer; Platelet Activating Factor; Sodium Chloride; Triazoles | 2004 |
Involvement of platelet activating factor in immediate heart response to lipopolysaccharide.
Topics: Animals; Azepines; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phospholipid Ethers; Platelet Activating Factor; Rats; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Triazoles | 2004 |
Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.
Topics: Alkaloids; Animals; Azepines; Benzophenanthridines; Cardiotonic Agents; Chromones; Coronary Circulation; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morpholines; Myocardial Reperfusion Injury; Myocardium; Necrosis; Perfusion; Phenanthridines; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Rats; Rats, Wistar; Triazoles; Ventricular Function, Left | 2005 |
Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor.
Topics: Animals; Azepines; Cell Line; Chemokine CXCL2; Chemokines, CXC; Dose-Response Relationship, Immunologic; Electrophoretic Mobility Shift Assay; Enterocytes; Gene Expression Regulation; I-kappa B Proteins; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Platelet Activating Factor; Pyrrolidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor.
Topics: Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Azepines; Binding, Competitive; Carrageenan; Cerebral Cortex; Dioxoles; Inflammation; Lignans; Male; Mice; Pain Measurement; Pain Threshold; Peroxidase; Phyllanthus; Plant Extracts; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pleurisy; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Tetrahydronaphthalenes; Time Factors; Triazoles | 2006 |
Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor.
Topics: Acute Disease; Animals; Azepines; Candida albicans; Kupffer Cells; Lipopolysaccharides; Liver; Male; Nitric Oxide; Pancreatitis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Taurocholic Acid; Triazoles; Tumor Necrosis Factors | 2007 |
Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases.
Topics: Animals; Azepines; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Flavonoids; Hypoxia; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; NF-kappa B; Oxygen; Platelet Activating Factor; Pulmonary Artery; Pulmonary Veins; Sheep; Structure-Activity Relationship; Triazoles | 2008 |
Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Azepines; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Imidazoles; Lipopolysaccharides; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles | 2011 |
Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells.
Topics: Albuterol; Azepines; Bronchi; Bronchodilator Agents; Cell Line; Cell Proliferation; Humans; Inositol 1,4,5-Trisphosphate; Myocytes, Smooth Muscle; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles | 2012 |
Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Organometallic Compounds; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rhodium; Structure-Activity Relationship; Thrombin; Triazoles | 2013 |