benztropine and methyl-iodide

benztropine has been researched along with methyl-iodide* in 1 studies

Other Studies

1 other study(ies) available for benztropine and methyl-iodide

Article	Year
On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1992, Volume: 43, Issue:9 A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified. Topics: Benztropine; Carbon Radioisotopes; Cyproheptadine; Doxepin; Hydrocarbons, Iodinated; Isotope Labeling; Methylation; Spiperone	1992

Article

Year

On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals.

International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1992, Volume: 43, Issue:9

A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.

Topics: Benztropine; Carbon Radioisotopes; Cyproheptadine; Doxepin; Hydrocarbons, Iodinated; Isotope Labeling; Methylation; Spiperone

1992