Page last updated: 2024-08-21

benzoxazoles and urea

benzoxazoles has been researched along with urea in 329 studies

Research

Studies (329)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.30)18.7374
1990's0 (0.00)18.2507
2000's84 (25.53)29.6817
2010's207 (62.92)24.3611
2020's37 (11.25)2.80

Authors

AuthorsStudies
DeLong, DC; Kisner, K; Paget, CJ; Stone, RL1
Arch, JR; Chapman, H; Haynes, AC; Jackson, B; Johns, A; Porter, RA; Tadayyon, M1
Ashmeade, TE; Gartlon, J; Hagan, JJ; Hatcher, JP; Hemmati, P; Hunter, AJ; Johns, A; Jones, DN; Munton, RP; Parker, F; Porter, RA; Routledge, C; Taylor, SG; Upton, N1
Brough, SJ; Jerman, JC; Jewitt, F; Johns, A; Porter, RA; Sabido-David, C; Smart, D1
Arch, JR; Blundell, JE; Canto de Souza, AL; Halford, JC; Johns, A; Nunes de Souza, RL; Piper, DC; Porter, RA; Rodgers, RJ; Upton, N1
Babbs, AJ; Bingham, S; Cutler, L; Davey, PT; Hunter, AJ; Irving, EA; Jeffrey, P; Johns, A; Parsons, AA; Porter, RA; Riba, I; Sammons, MJ; Upton, N; Wyles, M1
Austin, N; Brough, SJ; Chan, WN; Coldwell, M; Coulton, S; Hadley, MS; Jeffrey, P; Jerman, JC; Jewitt, F; Johns, A; Porter, RA; Smart, D; Widdowson, K1
Benham, CD; Davies, CH; Evans, ML; Gill, CH; Harries, MH; Soffin, EM1
Arch, JR; Cawthorne, MA; Chapman, H; Clapham, JC; Haynes, AC; Moore, GB; Tadayyon, M; Taylor, C1
Arch, JR; Haynes, AC; Smart, D; Williams, G1
Chiba, T; Nozaki-Taguchi, N; Yamamoto, T1
Hayashi, H; Kaibara, M; Matsuo, K; Nakane, Y; Taniyama, K; Uezono, Y1
Duxon, MS; Piper, DC; Smith, MI; Upton, N1
Buijs, RM; Davies, CH; Lee, K; Nolan, MF; Richardson, PJ; Spanswick, D; van den Top, M1
Bloom, SR; Coen, CW; Goubillon, ML; Grimshaw, SE; Kalamatianos, T; Kennedy, AR; Murray, JF; Siddiqui, A; Sivanesan, V; Small, CJ; Wilson, CA; Young, H1
Ehrström, M; Hellström, PM; Kirchgessner, AL; Ma, J; Näslund, E1
Hirota, K; Kudo, M; Kudo, T; Kushikata, T; Matsuki, A; Smart, D1
Cheng, JK; Chiou, LC; Chou, RC; Hwang, LL1
Hirota, K; Jerman, JC; Kudo, M; Kushikata, T; Lambert, DG; Matsuki, A; Smart, D; Yoshida, H1
Baghdoyan, HA; Bernard, R; Lydic, R1
Gao, J; Li, Y; Owyang, C; Wu, X; Yan, J1
Kiwaki, K; Kotz, CM; Lanningham-Foster, L; Levine, JA; Wang, C1
Brough, SJ; Herdon, HJ; Jerman, JC; Langmead, CJ; Porter, RA; Scott, C1
Blundell, JE; Halford, JC; Ishii, Y; Johns, A; Porter, R; Rodgers, RJ; Upton, N2
Brough, SJ; Davies, CH; Gill, CH; Jerman, JC; Soffin, EM1
Chase, MH; Fung, SJ; Xi, M; Yamuy, J1
Armstrong, DL; Oomura, Y; Phelix, CF; Wayner, MJ1
Blundell, JE; Halford, JC; Ishii, Y; Jeffrey, P; Johns, A; Porter, R; Rodgers, RJ; Summerfield, S; Upton, N1
Gaus, S; Kajiyama, S; Kawamoto, M; Matsunaga, A; Shiraishi, S; Suyama, H; Yuge, O1
Bray, GA; Ishii, Y; Mendoza, T; Stasi, LP; Upton, N; White, CL; York, DA1
Kotz, CM; Thorpe, AJ1
Hirota, K; Kudo, M; Kudo, T; Kushikata, T; Tose, R; Yoshida, H1
Boutrel, B; de Lecea, L; Kenny, PJ; Koob, GF; Markou, A; Martin-Fardon, R; Specio, SE1
Hashimoto, S; Khotib, J; Miyatake, M; Nagumo, Y; Nakamachi, T; Narita, M; Sakurai, T; Shioda, S; Suzuki, T; Yanagisawa, M1
Aimoto, S; Akutsu, H; Ikegami, T; Nagai, K; Nakagawa, A; Nakano, M; Takai, T; Takaya, T1
Bonci, A; Borgland, SL; Fields, HL; Sarti, F; Taha, SA1
Dong, HL; Fukuda, S; Higuchi, T; Murata, E; Zhu, Z1
Chen, F; Cowen, MS; Lawrence, AJ; Oldfield, B; Yang, HJ1
Azuma, YT; Hata, F; Nakajima, H; Okishio, Y; Satoh, Y; Takeuchi, T1
Akbari, E; Motamedi, F; Naghdi, N2
D'Anna, KL; Gammie, SC1
Hsu, MA; Rasmussen, K; Yang, Y1
Akerman, S; Goadsby, PJ; Holland, PR1
Ceregrzyn, M; Kato, I; Korczynski, W; Wolinski, J; Zabielski, R1
Briski, K; Kale, A; Paranjape, S; Vavaiya, K1
Branconi, JL; Fenik, VB; Kubin, L; Lu, JW; Mann, GL; Rukhadze, I1
Akerman, KE; Bengtsson, MW; Flemström, G; Herzig, KH; Mäkelä, K; Sjöblom, M; Uotila, S1
Libertun, C; Lux-Lantos, V; Silveyra, P1
Hemrick-Luecke, SK; Hsu, MA; Johnson, BG; Noone, S; Rasmussen, K; Thompson, LK1
Deng, BS; Fukuda, Y; Kuwaki, T; Nakamura, A; Yanagisawa, M; Zhang, W1
Fadel, J; Frederick-Duus, D; Guyton, MF1
Akbari, E; Motamedi, F; Naghdi, N; Noorbakhshnia, M1
Cools, AR; Ikeda, H; Koshikawa, N; Kotani, A1
Hirota, K; Kudo, M; Kudo, T; Kushikata, T; Yoshida, H1
Golden, SA; Nair, SG; Shaham, Y1
Albericio, F; Armand-Ugón, M; El-Faham, A; Esté, JA1
Chen, XW; Fan, HX; Gu, JL; Guo, N; Hu, ZA; Huang, W; Lü, J; Ruan, HZ; Xiu, Y; Yan, JA; Yu, ZP; Zhang, CX; Zhou, Z1
Dileone, RJ; Sarhan, M; Sharf, R1
Chen, J; Conner, AC; Ramanjaneya, M; Randeva, HS; Stanfield, PR1
Bartlett, SE; Bonci, A; Borgland, SL; Richards, JK; Simms, JA; Steensland, P; Taha, SA1
Shono, K; Yamamoto, T1
Aston-Jones, G; Gompf, HS1
Bai, YJ; Han, J; Li, YH; Sui, N; Yang, XY; Zheng, XG1
Gamo, Y; Hanawa, T; Ito, N; Nagai, T; Oikawa, T; Yabe, T; Yamada, H1
Chen, XW; Ge, L; Huang, W; Song, B; Yan, JA; Yu, ZP1
Cameron, MD; Hollander, JA; Kamenecka, TM; Kenny, PJ; Lu, Q1
Bengtsson, MW; Flemström, G; Herzig, KH; Mäkelä, K1
Baccari, MC; Bani, D; Calamai, F1
Furukawa, K; Hirota, K; Kudo, M; Kushikata, T; Tose, R; Ueno, S; Yoshida, H1
Eliassi, A; Naghdi, N; Nazari, M1
Jochem, J1
Dias, MB; Li, A; Nattie, EE1
Douglas, SA; Furukawa, K; Hashiba, E; Hirota, K; Kawaguchi, Y; Kudo, M; Kudo, T; Kushikata, T; Ono, T; Yoshida, H1
Cannella, N; Ciccocioppo, R; Economidou, D; Heilig, M; Kallupi, M; Massi, M; Stopponi, S1
Holden, JE; Jeong, Y1
Brown, JE; Chen, J; Conner, AC; Jöhren, O; Kumar, P; Lehnert, H; Ramanjaneya, M; Randeva, HS; Stanfield, PR1
Inyushkin, A; Karnas, D; Klisch, C; Meissl, H; Mordel, J; Pévet, P1
Alcin, E; Ayar, A; Kelestimur, H; Ozcan, M; Sahin, Z; Serhatlioglu, I1
Boschen, KE; Burk, JA; Fadel, JR1
Aston-Jones, G; Smith, RJ; Tahsili-Fahadan, P1
Kirouac, GJ; Li, S; Li, Y; Sui, N1
Aston-Jones, G; See, RE; Smith, RJ1
Aston-Jones, G; Moorman, DE1
Hedou, G; Heidbreder, C; Hutcheson, DM; Quarta, D; Valerio, E1
Bonci, A; Borgland, SL; Bowers, MS; Chang, SJ; Chen, BT; Chou, J; Floresco, SB; Thompson, JL; Vittoz, N1
Aston-Jones, G; Chen, J; Gompf, H; Kelz, MB; Sun, Y; Yanagisawa, M1
Chen, F; Chen, X; Hu, Z; Li, B; Li, Y; Xia, J; Xiong, Y; Yan, J; Ye, J; Zhou, Z1
Wang, JJ; Yu, L; Zhang, J; Zhang, XY; Zhu, JN1
Dias, MB; Li, A; Nattie, E1
Baghdoyan, HA; Lydic, R; Watson, CJ; Watson, SL1
DiLeone, RJ; Guarnieri, DJ; Sharf, R; Taylor, JR1
Birnbaum, S; Chuang, JC; Lutter, M; Osborne-Lawrence, S; Perello, M; Rovinsky, SA; Sakata, I; Woloszyn, J; Yanagisawa, M; Zigman, JM1
Brookshire, BR; España, RA; Jones, SR; Locke, JL; Oleson, EB; Roberts, DC1
Berrendero, F; de Lecea, L; Maldonado, R; Martín-García, E; Plaza-Zabala, A1
Benoit, SC; Choi, DL; Davis, JF; Fitzgerald, ME1
Corrigall, WA; Kotz, CM; LeSage, MG; Perry, JL; Shelley, D1
Brayton, CE; DiLeone, RJ; Guarnieri, DJ; Sarhan, M; Sharf, R; Taylor, JR1
Acar, N; Bülbül, M; Gemici, B; Izgüt-Uysal, VN; Ozdem, S; Tan, R; Ustünel, I1
De Carolis, L; Milella, MS; Nativio, P; Nencini, P; Passarelli, F; Scaccianoce, S; Schepisi, C1
Dickson, SL; Egecioglu, E; Engel, JA; Jerlhag, E1
Azizi, H; Mirnajafi-Zadeh, J; Rohampour, K; Semnanian, S1
Allen, AM; Oldfield, BJ; Verty, AN1
Babygirija, R; Bülbül, M; Ludwig, K; Takahashi, T1
Akbari, E; Davoodi, FG; Ghanbarian, E; Motamedi, F; Noorbakhshnia, M1
Haghparast, A; Hassanpour-Ezatti, M; Safari, MS; Taslimi, Z1
Chen, X; Kirouac, GJ; Li, S; Li, Y; Qi, K; Sui, N; Wang, H1
Dezsi, G; Jupp, B; Krstew, E; Lawrence, AJ1
Pilowsky, PM; Rahman, AA; Shahid, IZ1
Baghdoyan, HA; Brevig, HN; Lydic, R; Watson, CJ1
Cunningham, CL; Voorhees, CM1
Onizuka, S; Shirasaka, T; Tsuneyoshi, I; Yonaha, T1
Milligan, G; Pediani, JD; Ward, RJ1
Halbout, B; Heidbreder, C; Hutcheson, DM; Quarta, D; Rigal, A; Valerio, E1
Cabello, V; Mediavilla, C; Risco, S1
He, YC; Li, B; Li, HZ; Wang, JJ; Yu, L; Zhang, J; Zhu, JN1
Cao, J; de Lecea, L; Ikemoto, S1
Birnbaum, SG; Elmquist, JK; Lutter, M; Marcus, JN; Mochizuki, T; Nestler, EJ; Pettersen, A; Scammell, TE; Scott, MM1
Kubin, L; Stettner, GM; Volgin, DV1
Jupp, B; Krivdic, B; Krstew, E; Lawrence, AJ1
Charnley, JL; Dayas, CV; James, MH; Jones, E; Levi, EM; Smith, DW; Yeoh, JW1
Gilmour, BP; Perrey, DA; Runyon, SP; Thomas, BF; Zhang, Y1
DiMicco, JA; Rusyniak, DE; Zaretskaia, MV; Zaretsky, DV1
Azuma, M; Kang, KS; Kojima, K; Maejima, S; Matsuda, K; Uchiyama, M; Yokobori, E1
Frohman, MA; Jäntti, MH; Kukkonen, JP; Putula, J; Somerharju, P1
Gemici, B; İzgüt-Uysal, VN; Tan, R1
Berrendero, F; Flores, Á; Maldonado, R; Plaza-Zabala, A1
Chen, Y; Fan, S; Hu, Z; Jia, X; Qi, A; Wang, T; Xia, J; Xiong, J; Yan, J; Yang, N; Ye, J1
Dossat, AM; Kay, K; Lilly, N; Overton, JM; Parise, EM; Seth, R; Williams, DL1
Chiou, LC; Fu, SY; Ho, YC; Lee, HJ; Liao, HT; Liao, YY; Mackie, K; Teng, SF; Tung, LW1
Chaleek, N; Eliassi, A; Haghparast, A; Kermani, M1
Blasiak, T; Lewandowski, MH; Pekala, D; Raastad, M1
Cano, G; Madden, CJ; Morrison, SF; Tupone, D1
Kukkonen, JP; Putula, J1
Altieri, F; Azzariti, A; Cervoni, L; Crestani, M; Di Giovanni, C; Fracchiolla, G; Gilardi, F; Giudici, M; Guerrini, U; Laghezza, A; Lavecchia, A; Loiodice, F; Mitro, N; Montanari, R; Paradiso, A; Piemontese, L; Pochetti, G; Porcelli, L; Simone, GM; Tortorella, P1
Fish, EW; Jarrett, TM; Malanga, CJ; McGuigan, MM; Riday, TT; Robinson, JE1
Cameron, MD; Chan, C; Ghee, SM; Kenny, PJ; Lin, L; See, RE; Zhou, L1
Aston-Jones, G; Smith, RJ1
DiMicco, JA; Durant, PJ; Rusyniak, DE; Zaretskaia, MV; Zaretsky, DV1
Aston-Jones, G; Mahler, SV; Smith, RJ1
Azizi, H; Fathollahi, Y; Ranjbar-Slamloo, Y; Semnanian, S1
Fitz, SD; Johnson, PL; Lightman, SL; Lowry, CA; Samuels, BC; Shekhar, A1
Aston-Jones, GS; Sartor, GC1
Jäntti, MH; Kukkonen, JP; Turunen, PM1
Cataldi, NI; Libertun, C; Lux-Lantos, VA1
Borroni, E; Kilduff, TS; Malherbe, P; Morairty, SR; Moreau, JL; Revel, FG; Valladao, D; Wettstein, JG1
Martin-Fardon, R; Weiss, F2
Azhdari-Zarmehri, H; Erami, E; Haghparast, A; Heidari-Oranjaghi, N1
Aston-Jones, G; Do, PH; See, RE; Smith, RJ; Zhou, L1
Bhatnagar, S; Heydendael, W; Sengupta, A1
Dehpour, AR; Esmaeili, B; Ghaffarpour, M; Javadi-Paydar, M; Mirbaha, H; Motiei-Langroudi, R; Tabaeizadeh, M; Tahsili-Fahadan, P1
Azhdari-Zarmehri, H; Erami, E; Ghasemi-Dashkhasan, E; Haghparast, A; Rahmani, A; Semnanian, S1
Brieaddy, L; Carroll, FI; Lewin, AH; Mascarella, SW; McElhinny, CJ; Runyon, S1
Aston-Jones, G; Cason, AM3
Rodgers, RJ; Snow, NF; Taylor, LJ; Wright, FL1
Berrendero, F; Flores, Á; Maldonado, R; Martín-García, E; Plaza-Zabala, A; Saravia, R1
Dai, YW; Huang, SC; Hwang, LL; Lee, YH; Li, TL1
Chen, F; Chen, H; Hu, B; Hu, ZA; Sui, JF; Wang, YJ; Yan, J; Yang, L; Yang, N; Zhu, ZR1
Gillman, AG; Kosobud, AE; Leffel, JK; Timberlake, W1
Liu, XM; Ni, LY; Song, Y; Tang, JY; Zhu, MJ1
Berrendero, F; Flores, Á; Maldonado, R1
Kay, K; Lilly, N; Parise, EM; Williams, DL1
Azhdari-Zarmehri, H; Esmaeili, MH; Haghdoost-Yazdi, H; Sofiabadi, M1
Billington, CJ; Kotz, CM; Teske, JA1
de Lecea, L; Farb, CR; Fink, AE; Ledoux, JE; Sears, RM; Wigestrand, MB1
Amadeo, A; Aracri, P; Banfi, D; Becchetti, A; Pasini, ME1
Liu, Xm; Ren, Yy; Tang, Jy; Tang, S; Yang, Wx; Zhang, Rx; Zhao, X1
Cornish, JL; Staples, LG1
Patrone, A; Perello, M; Reynaldo, M; Valdivia, S1
Mediavilla, C; Risco, S2
Fujita, M; Kobashi, M; Matsuo, R; Mitoh, Y; Mizutani, S; Shimatani, Y1
Cone, JJ; McCutcheon, JE; Roitman, MF1
Duncan, MJ; Franklin, KM; Legan, SJ; Peng, X; Yun, C1
Harada, S; Koda, S; Tokuyama, S; Yamazaki, Y1
Fatahi, Z; Haghparast, A; Sarihi, A; Zarepour, L1
Chang, X; Guo, L; Ju, SJ; Zhao, Y1
Adidharma, W; Deats, SP; Lonstein, JS; Yan, L1
Karasawa, H; Taché, Y; Wang, L; Yakabi, S1
Berrendero, F; Costa, G; Flores, Á; Maldonado, R; Saravia, R; Valls-Comamala, V1
Iinuma, N; Konno, N; Matsuda, K; Nakamachi, T; Sakashita, A; Shibata, H; Wada, K1
Azizi, H; Javan, M; Mirnajafi-Zadeh, J; Mousavi, Y; Semnanian, S1
Alcaraz-Iborra, M; Carvajal, F; Cubero, I; Lerma-Cabrera, JM; Valor, LM1
Azizi, H; Ghaemi-Jandabi, M; Semnanian, S1
Routh, VH; Santiago, AM; Sheng, Z; Thomas, MP1
Le Foll, C; Levin, BE; Otlivanchik, O1
Chang, X; Guo, L; Ju, S; Zhao, Y1
Chen, ZP; Wang, JJ; Yu, L; Zhang, XY; Zhu, JN; Zhuang, QX1
Fatahi, Z; Haghparast, A; Moradi, M; Rashidy-Pour, A1
Cornish, JL; Staples, LG; Vanderhaven, MW1
España, RA; Prince, CD; Rau, AR; Yorgason, JT1
Kumei, S; Miyagishi, S; Nozu, T; Ohhira, M; Okumura, T; Takakusaki, K2
Elahdadi Salmani, M; Goudarzi, E; Goudarzi, I; Lashkarbolouki, T1
Navarro, M; Olney, JJ; Thiele, TE2
Arezoomandan, R; Fatahi, Z; Haghparast, A; Riahi, E1
Aston-Jones, G; Bentzley, BS1
Cui, Y; Guo, SJ; Huang, ZZ; Jiang, JX; Liu, H; Xin, WJ; Zhang, XQ1
Abbasnejad, M; Amirkhosravi, L; Esmaeili-Mahani, S; Kooshki, R; Rafie, F; Raoof, M; Raoof, R; Sheibani, V1
Alcaraz-Iborra, M; Carvajal, F; Cubero, I; de la Fuente, L; Lerma-Cabrera, JM; Sanchez-Amate, Mdel C; Valor, LM1
Chen, QH; He, C; Hu, ZA; Li, C; Xia, JX; Yang, L; Ye, JN; Zhang, J1
Brown, RM; Jupp, B; Khoo, SY; Kim, AK; Kim, JH; Lawrence, AJ1
Behrouzvaziri, A; Fu, D; Molkov, YI; Rusyniak, DE; Tan, P; Yoo, Y; Zaretskaia, MV; Zaretsky, DV1
Chrobok, L; Lewandowski, MH; Palus, K1
Bernstein, DL; Brodnik, ZD; España, RA; Prince, CD1
Carfagna, C; Della Ca', N; Fini, F; Gabriele, B; Mancuso, R; Raut, DS1
Alaii, E; Emam, AH; Komaki, A; Panah, MH; Sarihi, A; Seif, S; Vafaeirad, M1
Ali Reza, M; Azizi, H; Mirnajafi-Zadeh, J; Mohammad-Pour Kargar, H; Semnanian, S1
Li, DP; Yuan, F; Zhang, Y; Zhou, JJ1
Gong, YL; Guo, FF; Peng, XY; Sun, XR; Xu, L1
Holden, JE; Jeong, Y; Wagner, M; Wardach, J1
Dunn-Meynell, A; Levin, BE; Otlivanchik, O; Sanders, NM1
Cole, S; Mayer, HS; Petrovich, GD1
Joshi, D; Singh, SK1
Alijanpour, S; Tirgar, F; Zarrindast, MR1
Aston-Jones, G; Bentzley, BS; Porter-Stransky, KA1
Korim, WS; Llewellyn-Smith, IJ; Verberne, AJ1
Ebrahimian, F; Haghparast, A; Naghavi, FS; Sadeghzadeh, F; Taslimi, Z; Yazdi, F1
Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Raoof, M2
Bícego, KC; Dias, MB; Fonseca, EM; Gargaglioni, LH; Vicente, MC1
Ayoobi, F; Fatemi, I; Motevalian, M; Roohbakhsh, A; Sanati, MH; Shamsizadeh, A; Taghipour, Z1
Babapour, V; Ezzatpanah, S; Haghparast, A1
Azizi, H; Davoudi, M; Mirnajafi-Zadeh, J; Semnanian, S1
Chang, LY; Chiou, LC; Ho, YC; Hwang, LL; Lee, HJ; Mackie, K; Teng, SF1
Socała, K; Szuster-Ciesielska, A; Wlaź, P1
Gong, Y; Guo, F; Hao, H; Luan, X; Sun, X; Xu, L1
Dong, HL; Liu, Y; Ouyang, PR; Ran, MZ; Tong, L; Yang, C; Zhang, LN; Zhang, ZC1
Cole, S; Keefer, SE; Petrovich, GD1
Fatahi, Z; Haghparast, A; Moradi, M; Parsania, S1
Benedetto, L; Ferreira, A; Rivas, M; Torterolo, P1
Abdollahi, H; Azizi, H; Ghaemi-Jandabi, M; Semnanian, S1
Esmaeili, MH; Ezzatpanah, S; Haghparast, A; Reisi, Z1
Chen, AQ; Chen, H; Chen, L; Chen, WF; Chen, XY; Liu, HX; Liu, HY; Pang, YY; Sheng, Q; Wang, Y; Xue, Y; Yang, YT1
Hopf, FW; Lei, K; Wegner, SA; Yu, JH1
Kerr, TM; Martin-Fardon, R; Matzeu, A; Weiss, F1
Abbasnejad, M; Bahaaddini, M; Esmaeili-Mahani, S; Khatamsaz, S; Raoof, M1
Herman, MA; Koob, GF; Roberto, M; Schmeichel, BE1
Kirouac, GJ; Li, S; Wang, H1
Hayward, LF; Hernandez, ME; Martin, EJ1
Asadi, S; Fereidoni, M; Kordi Jaz, E; Moghimi, A; Roohbakhsh, A; Shamsizadeh, A1
Farahmandfar, M; Kadivar, M; Rastipisheh, S1
Aston-Jones, G; James, MH; Kilroy, EA; Moorman, DE1
Azizi, H; Hooshmand, B; Javan, M; Semnanian, S1
Angeli, A; Bartolucci, G; Carta, F; Nocentini, A; Peat, TS; Supuran, CT1
Kim, MS; Minamino, N; Nakazato, M; Namkoong, C; Sakoda, H; Sasaki, K; Toshinai, K; Ueta, Y; Waise, TMZ1
Akbari, E; Ardeshiri, MR; Hosseinmardi, N3
Bowyer, SL; Kassiou, M; O'Brien-Brown, J; Reekie, TA; Werry, EL; Wong, ECN1
Berrendero, F; Flores, Á; Herry, C; Maldonado, R1
Doostmohammadi, J; Hooshmandi, M; Hosseinmardi, N; Janahmadi, M; Khakpai, F; Rohampour, K1
Brailoiu, E; Connelly, KL; Gentile, TA; Muschamp, JW; Simmons, SJ; Watson, MN; Zhang, Y1
Farahimanesh, S; Haghparast, A; Zarrabian, S1
Liu, LL; Qiao, SN; Zhang, DQ; Zhong, YM; Zhou, W1
Alizadeh, AM; Ezzatpanah, S; Haghparast, A; Shafiei, I1
Chen, AQ; Chen, L; Chu, HY; Liu, C; Liu, YH; Sheng, Q; Wang, Y; Xue, Y1
Haghparast, A; Karimi-Haghighi, S; Mousavi, Z; Sahafzadeh, M1
Farahimanesh, S; Haghparast, A; Karimi, S1
Babapour, V; Haghparast, A; Pourreza, P1
Kumei, S; Nozu, T; Ohhira, M; Okumura, T; Takakusaki, K1
Baranowska-Bosiacka, I; Gutowska, I; Kotlińska, J; Listos, J; Listos, P; Talarek, S; Tarnowski, M; Łupina, M1
Bangasser, DA; Bhatnagar, S; Blume, SR; Luz, S; Nam, H1
Fujita, T; Kumamoto, E; Wang, C1
Fazli-Tabaei, S; Haghparast, A; Karimi-Haghighi, S; Rezaee, L1
Evans, SM; Foltin, RW1
Abbasnejad, M; Esmaeili-Mahani, S; Raoof, M; Shahsavari, F1
Azizi, H; Kargar, HM; Mani, AR; Mirnajafi-Zadeh, J; Semnanian, S1
Aldavert-Vera, L; Álvarez, A; García-Brito, S; Huguet, G; Kádár, E; Segura-Torres, P1
Edalat, P; Haghparast, A; Kavianpour, M; Zarrabian, S1
Joshi, D; Sarkar, D; Singh, SK1
Han, X; Peng, W; Zhou, J1
Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Mansoori, M; Raoof, M; Soofiabadi, S1
Hosseini, A; Khazali, H1
Aston-Jones, G; Bowrey, HE; James, MH; Koll, NE; Stopper, CM; Zimmer, BA1
Fatahi, Z; Haghparast, A; Hamidi, G; Karimi, S1
Aston-Jones, G; Bowrey, HE; James, MH; Stopper, CM1
Guo, F; Han, X; Luan, X; Sun, X; Wang, C; Xu, L1
Alijanpour, S; Ebrahimi-Ghiri, M; Khakpai, F; Zarrindast, MR1
Bahramzadeh Zoeram, S; Elahdadi Salmani, M; Goudarzi, I; Lashkarbolouki, T1
Kaneko, K; Kobayashi, M; Oi, Y; Usui, M1
Bian, H; Hu, Q; Huang, L; Li, B; Liang, X; Tang, J; Zhang, JH1
Aston-Jones, G; James, MH; Wiskerke, J1
Chikahisa, S; Miyatake, Y; Otsuka, A; Sakaue, H; Séi, H; Shiuchi, T1
Aston-Jones, G; Fragale, JE; James, MH; Pantazis, CB1
Brojeni, MS; Haghparast, A; Rashvand, M1
Assar, N; Haghparast, A; Mahmoudi, D; Mousavi, Z; Zarrabian, S1
Aston-Jones, G; James, MH; Mohammadkhani, A; Pantazis, CB1
Aston-Jones, G; Bowrey, HE; Fragale, JE; James, MH; Mohammadkhani, A; Pantazis, CB1
Furukawa, J; Maehara, S; Ota, T1
Igarashi, S; Ishioh, M; Kumei, S; Nozu, T; Ohhira, M; Okumura, T1
Haghparast, A; Jamali, S; Motamedi, F; RayatSanati, K; Shirazy, M1
Cui, C; Jia, M; Li, Y; Ma, H; Miao, D; Wu, L; Yang, M1
Kim, JS; Martin-Fardon, R1
Martin-Fardon, R; Matzeu, A1
Behnaz, M; Haghparast, A; Rahimitabar, N; Rezaee, L; Safari-Sandiani, E1
Haghparast, A; Matini, T; Rahban, M; Rezaee, L; Tehranchi, A1
Haghparast, A; Kashfi, K; Manaheji, H; Salehi, S1
Bayramoğlu, O; Bülbül, M; Sinen, O1
Abrari, K; Elahdadi Salmani, M; Lashkarbolouki, T; Nasiri, M; Salehabadi, S1
Matsuura, W; Nakamoto, K; Tokuyama, S1
Aston-Jones, G; Bentzley, BS; Freeman, LR; James, MH1
Coiduras, II; Maske, CB; Parise, EM; Williams, DL1
Joghataei, MT; Komaki, A; Kourosh-Arami, M; Mohsenzadegan, M1
Haghparast, A; Jamali, S; Karimi-Haghighi, S; Khosrowabadi, E1
Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Raoof, M; Sheibani, V1
Gholami, M; Joghataei, MT; Komaki, A; Kourosh-Arami, M; Lavaie, M; Najafi, Z1
Haghparast, A; Karimi-Haghighi, S; Mahmoudi, M; Maleki-Roveshti, M2
Aston-Jones, G; Fragale, JE; James, MH1
Campus, P; Covelo, IR; Flagel, SB; Haight, JL; Johnson, AM; Klumpner, MS; Kuhn, BN; Maria-Rios, CE; Morrow, JD1
Assar, N; Azizi, P; Haghparast, A; Katebi, SN; Mahmoudi, D; Mousavi, Z1
Campbell, EJ; Hill, MK; Jin, S; Lawrence, AJ; Maddern, XJ; Pang, TY1
Akbari, E; Ardeshiri, MR; Khodabande, F1
Aghajani, N; Azizi, H; Pourhamzeh, M; Semnanian, S1
Haghparast, A; Hassanlou, AA; Jamali, S; RayatSanati, K1
Dong, X; Feng, Z; Liu, H; Lu, G; Tang, Y; Wang, J; Xiong, J; Ye, W; Zhong, L1
Abbasnejad, M; Askari-Zahabi, K; Esmaeili-Mahani, S; Kooshki, R1
Haghparast, A; Karimi-Haghighi, S; Zargarani, A1
Haghparast, A; Jamali, S; Zarrabian, S1
Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Pourrahimi, AM; Raoof, M1
Askari, K; Ghalebandi, S; Haghparast, A; Mousavi, Z; Zareie, F1
Durairaja, A; Fendt, M; Steinecke, CS1
Alibeik, H; Bananej, M; Khakpai, F; Saadati, N; Zarrindast, MR1

Reviews

3 review(s) available for benzoxazoles and urea

ArticleYear
Orexins and the treatment of obesity.
    European journal of pharmacology, 2002, Apr-12, Volume: 440, Issue:2-3

    Topics: Animals; Benzoxazoles; Body Weight; Carrier Proteins; Eating; Humans; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Obesity; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2002
[Orexin: clinical and therapeutic implications].
    Revista de neurologia, 2014, Feb-01, Volume: 58, Issue:3

    Topics: Animals; Arousal; Azepines; Benzoxazoles; Disease Models, Animal; Drug Evaluation, Preclinical; Feeding and Eating Disorders; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Mice, Transgenic; Motor Activity; Naphthyridines; Narcolepsy; Neuropeptides; Obesity; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Sleep Disorders, Circadian Rhythm; Sleep Disorders, Intrinsic; Substance-Related Disorders; Triazoles; Urea

2014
Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior.
    Alcoholism, clinical and experimental research, 2020, Volume: 44, Issue:2

    Topics: Alcoholism; Animals; Benzoxazoles; Compulsive Behavior; Corticotropin-Releasing Hormone; Drug-Seeking Behavior; Humans; Naphthyridines; Orexins; Prefrontal Cortex; Protein Binding; Urea

2020

Other Studies

326 other study(ies) available for benzoxazoles and urea

ArticleYear
Heterocyclic substituted ureas. II. Immunosuppressive and antiviral activity of benzothiazole- and benzoxazoleureas.
    Journal of medicinal chemistry, 1969, Volume: 12, Issue:6

    Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Antiviral Agents; Benzoxazoles; Chemical Phenomena; Chemistry; Coxsackievirus Infections; Erythrocytes; Immunosuppressive Agents; Mice; Sheep; Thiazoles; Urea

1969
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.
    Regulatory peptides, 2000, Dec-22, Volume: 96, Issue:1-2

    Topics: Animals; Appetite Depressants; Benzoxazoles; Carrier Proteins; Darkness; Eating; Fasting; Female; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Obesity; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2000
Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.
    Psychopharmacology, 2001, Jan-01, Volume: 153, Issue:2

    Topics: Animals; Benzoxazoles; Body Temperature; Brain Chemistry; Carrier Proteins; Grooming; Intracellular Signaling Peptides and Proteins; Motor Activity; Naphthyridines; Neuropeptides; Neurosecretory Systems; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reflex, Startle; Urea

2001
SB-334867-A: the first selective orexin-1 receptor antagonist.
    British journal of pharmacology, 2001, Volume: 132, Issue:6

    Topics: Animals; Benzoxazoles; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Fluorometry; Humans; Naphthyridines; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Transfection; Urea

2001
SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.
    The European journal of neuroscience, 2001, Volume: 13, Issue:7

    Topics: Animals; Appetitive Behavior; Benzoxazoles; Body Weight; Carrier Proteins; Eating; Hyperphagia; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Inbred Strains; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Satiety Response; Urea

2001
Orexin-A, an hypothalamic peptide with analgesic properties.
    Pain, 2001, Volume: 92, Issue:1-2

    Topics: Abdomen; Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Benzoxazoles; Carrageenan; Carrier Proteins; Female; Ganglia, Spinal; Hyperalgesia; Hypothalamus; Immunohistochemistry; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred ICR; Naloxone; Naphthyridines; Narcotic Antagonists; Neuropeptides; Nociceptors; Orexin Receptors; Orexins; Pain Threshold; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Spinal Cord; Urea

2001
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
    Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14

    Topics: Animals; Benzoxazoles; Blood-Brain Barrier; Central Nervous System; CHO Cells; Cricetinae; Humans; Indoles; Infusions, Intravenous; Naphthyridines; Orexin Receptors; Permeability; Quinolines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sensitivity and Specificity; Structure-Activity Relationship; Urea

2001
SB-334867-A antagonises orexin mediated excitation in the locus coeruleus.
    Neuropharmacology, 2002, Volume: 42, Issue:1

    Topics: Action Potentials; Animals; Benzoxazoles; Carrier Proteins; Electrophysiology; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Locus Coeruleus; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, Neuropeptide; Urea

2002
Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.
    Regulatory peptides, 2002, Mar-15, Volume: 104, Issue:1-3

    Topics: Adipose Tissue, Brown; Animals; Benzoxazoles; Body Composition; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Energy Metabolism; Female; Insulin; Mice; Mice, Inbred Strains; Naphthyridines; Obesity; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; RNA, Messenger; Urea

2002
Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test.
    British journal of pharmacology, 2002, Volume: 137, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Benzoxazoles; Carrier Proteins; Dose-Response Relationship, Drug; Immunohistochemistry; Injections, Spinal; Intracellular Signaling Peptides and Proteins; Male; Naloxone; Naphthyridines; Neuropeptides; Orexins; Pain Measurement; Rats; Rats, Sprague-Dawley; Urea

2002
Involvement of cholinergic neurons in orexin-induced contraction of guinea pig ileum.
    European journal of pharmacology, 2002, Sep-27, Volume: 452, Issue:1

    Topics: Acetylcholine; Animals; Atropine; Benzoxazoles; Carrier Proteins; Enteric Nervous System; Female; Ganglionic Blockers; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Parasympathetic Nervous System; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Tetrodotoxin; Urea

2002
Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat.
    Neuroscience letters, 2003, May-08, Volume: 341, Issue:3

    Topics: Animals; Benzoxazoles; Carrier Proteins; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep, REM; Urea

2003
Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones.
    The Journal of physiology, 2003, Jun-15, Volume: 549, Issue:Pt 3

    Topics: Adrenergic Fibers; Animals; Autonomic Fibers, Preganglionic; Benzoxazoles; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; GTP-Binding Proteins; Hypothalamic Area, Lateral; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Potentials; Microscopy, Confocal; Microscopy, Video; Naphthyridines; Neural Pathways; Neurons; Neuropeptides; Orexins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Urea

2003
Central orexin A has site-specific effects on luteinizing hormone release in female rats.
    Endocrinology, 2003, Volume: 144, Issue:7

    Topics: Animals; Benzoxazoles; Carrier Proteins; Cells, Cultured; Estradiol; Female; Gonadotropin-Releasing Hormone; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Luteinizing Hormone; Microinjections; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Ovariectomy; Preoptic Area; Progesterone; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2003
Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:4

    Topics: Animals; Benzoxazoles; Carrier Proteins; Duodenum; Electromyography; Guanethidine; Homeostasis; Immunohistochemistry; Intestine, Small; Intracellular Signaling Peptides and Proteins; Male; Myoelectric Complex, Migrating; Naphthyridines; Neuropeptides; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea; Vagotomy

2003
Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats.
    Brain research, 2003, Aug-15, Volume: 981, Issue:1-2

    Topics: Aging; Animals; Benzoxazoles; Blood Gas Analysis; Blood Pressure; Carrier Proteins; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Heart Rate; Hemodynamics; Hemoglobins; In Vitro Techniques; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Norepinephrine; Orexins; Potassium Chloride; Rats; Time Factors; Urea

2003
Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Animals; Antibodies, Blocking; Benzoxazoles; Carrier Proteins; Exophthalmos; gamma-Aminobutyric Acid; Glycine Agents; Injections, Spinal; Intracellular Signaling Peptides and Proteins; Male; Naloxone; Naphthyridines; Narcotic Antagonists; Neuropeptides; Orexin Receptors; Orexins; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Glycine; Receptors, Neuropeptide; Receptors, Purinergic P2; Strychnine; Suramin; Synaptic Transmission; Urea

2003
Orexinergic neurons and barbiturate anesthesia.
    Neuroscience, 2003, Volume: 121, Issue:4

    Topics: Animals; Barbiturates; Benzoxazoles; Brain; Carrier Proteins; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Locus Coeruleus; Male; Naphthyridines; Neurons; Neuropeptides; Norepinephrine; Orexin Receptors; Orexins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Urea

2003
Hypocretin-1 causes G protein activation and increases ACh release in rat pons.
    The European journal of neuroscience, 2003, Volume: 18, Issue:7

    Topics: Acetylcholine; Animals; Autoradiography; Benzoxazoles; Carrier Proteins; Dialysis; Dose-Response Relationship, Drug; Drug Interactions; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Pons; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sulfur Isotopes; Time Factors; Urea

2003
Hypothalamus-brain stem circuitry responsible for vagal efferent signaling to the pancreas evoked by hypoglycemia in rat.
    Journal of neurophysiology, 2004, Volume: 91, Issue:4

    Topics: Action Potentials; Animals; Benzoxazoles; Blood Glucose; Brain Stem; Carrier Proteins; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Glucose; Hypoglycemia; Hypothalamus; Immunohistochemistry; Insulin; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Microinjections; Naphthyridines; Neural Pathways; Neurons, Efferent; Neuropeptide Y; Neuropeptides; Nodose Ganglion; Orexins; Pancreas; Rats; Rats, Sprague-Dawley; Serotonin; Splanchnic Nerves; Urea; Vagus Nerve

2004
Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:4

    Topics: Animals; Benzoxazoles; Calorimetry, Indirect; Carbon Dioxide; Carrier Proteins; Dose-Response Relationship, Drug; Feeding Behavior; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Motor Activity; Naphthyridines; Neuropeptides; Orexins; Oxygen Consumption; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Thermogenesis; Urea

2004
Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.
    British journal of pharmacology, 2004, Volume: 141, Issue:2

    Topics: Animals; Benzoxazoles; CHO Cells; Cricetinae; Humans; Naphthyridines; Orexin Receptors; Protein Binding; Pyrrolidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thiazoles; Tritium; Urea

2004
Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats.
    Physiology & behavior, 2004, Volume: 81, Issue:1

    Topics: Animals; Appetite; Appetite Depressants; Benzoxazoles; Body Weight; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Lithium Chloride; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Inbred Strains; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Satiety Response; Urea

2004
Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus.
    Neuropharmacology, 2004, Volume: 46, Issue:8

    Topics: Animals; Benzoxazoles; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Male; Naphthyridines; Orexin Receptors; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2004
Hypocretinergic control of spinal cord motoneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-09, Volume: 24, Issue:23

    Topics: Animals; Benzoxazoles; Carrier Proteins; Cataplexy; Cats; Electric Stimulation; Hypothalamus; Intracellular Signaling Peptides and Proteins; Membrane Potentials; Motor Neurons; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Spinal Cord; Sympathomimetics; Urea

2004
Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo.
    Peptides, 2004, Volume: 25, Issue:6

    Topics: Animals; Benzoxazoles; Dentate Gyrus; Dose-Response Relationship, Drug; Intracellular Signaling Peptides and Proteins; Leptin; Long-Term Potentiation; Naphthyridines; Neuropeptides; Orexins; Rats; Rats, Sprague-Dawley; Urea

2004
Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867.
    Behavioural brain research, 2005, Feb-28, Volume: 157, Issue:2

    Topics: Activity Cycles; Analysis of Variance; Animals; Anorexia; Appetite Depressants; Benzoxazoles; Body Weight; Drug Administration Schedule; Eating; Feeding Behavior; Injections, Intraperitoneal; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Inbred Strains; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Time Factors; Urea; Weight Loss

2005
Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S.
    Behavioural brain research, 2005, May-07, Volume: 160, Issue:1

    Topics: Analysis of Variance; Animals; Appetite; Behavior, Animal; Benzoxazoles; Body Weight; Drinking; Eating; Food Deprivation; Male; Naphthyridines; Nootropic Agents; Orexin Receptors; Rats; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Satiety Response; Sincalide; Time Factors; Urea

2005
Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats.
    Brain research, 2005, May-17, Volume: 1044, Issue:1

    Topics: Animals; Behavior, Animal; Benzoxazoles; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Injections, Spinal; Intracellular Signaling Peptides and Proteins; Male; Naloxone; Naphthyridines; Narcotic Antagonists; Neuropeptides; Orexin Receptors; Orexins; Pain Measurement; Pain Threshold; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Spinal Cord; Streptozocin; Time Factors; Urea

2005
Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity.
    Peptides, 2005, Volume: 26, Issue:11

    Topics: Animals; Benzoxazoles; Body Weight; Diet; Eating; Gene Expression Regulation; Hypothalamus; Male; Naphthyridines; Obesity; Orexin Receptors; Protein Precursors; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; RNA, Messenger; Species Specificity; Urea

2005
Orexin A in the nucleus accumbens stimulates feeding and locomotor activity.
    Brain research, 2005, Jul-19, Volume: 1050, Issue:1-2

    Topics: Animals; Benzoxazoles; Feeding Behavior; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Motor Activity; Naphthyridines; Neuropeptides; Nucleus Accumbens; Orexins; Rats; Rats, Sprague-Dawley; Urea

2005
Lack of interaction between orexinergic and alpha2-adrenergic neuronal systems in rat cerebrocortical slices.
    Neuroscience letters, 2005, Oct-14, Volume: 387, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzoxazoles; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Intracellular Signaling Peptides and Proteins; Locus Coeruleus; Male; Naphthyridines; Neural Pathways; Neurons; Neuropeptides; Norepinephrine; Orexin Receptors; Orexins; Organ Culture Techniques; Potassium; Rats; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep; Urea; Wakefulness; Yohimbine

2005
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Dec-27, Volume: 102, Issue:52

    Topics: Analysis of Variance; Animals; Behavior, Addictive; Benzoxazoles; Brain; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Intracellular Signaling Peptides and Proteins; Male; Models, Statistical; Naphthyridines; Neuropeptides; Orexins; Rats; Rats, Wistar; Reward; Self Administration; Time Factors; Urea

2005
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-11, Volume: 26, Issue:2

    Topics: Animals; Benzoxazoles; Conditioning, Operant; Desipramine; Dopamine; Female; Haloperidol; Injections, Intraventricular; Injections, Subcutaneous; Intracellular Signaling Peptides and Proteins; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Microdialysis; Microinjections; Morphine; Motor Activity; Naphthyridines; Neuropeptides; Nucleus Accumbens; Orexins; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reward; RNA, Messenger; Tyrosine 3-Monooxygenase; Urea; Ventral Tegmental Area

2006
Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor.
    Journal of peptide science : an official publication of the European Peptide Society, 2006, Volume: 12, Issue:7

    Topics: Amino Acid Sequence; Benzoxazoles; Binding Sites; Conserved Sequence; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Micelles; Models, Molecular; Molecular Sequence Data; Naphthyridines; Neuropeptides; Nuclear Magnetic Resonance, Biomolecular; Orexin Receptors; Orexins; Protein Conformation; Protein Structure, Secondary; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2006
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.
    Neuron, 2006, Feb-16, Volume: 49, Issue:4

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Benzoxazoles; Calcium Channel Blockers; Cocaine; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lysine; Male; Motor Activity; N-Methylaspartate; Naphthyridines; Neuronal Plasticity; Neurons; Neuropeptides; Orexins; Patch-Clamp Techniques; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Synapses; Thionucleotides; Time Factors; Tyrosine 3-Monooxygenase; Urea; Ventral Tegmental Area

2006
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
    Anesthesiology, 2006, Volume: 104, Issue:5

    Topics: Acetylcholine; Anesthetics, Inhalation; Animals; Arousal; Basal Ganglia; Benzoxazoles; Cerebral Cortex; Electric Stimulation; Electroencephalography; Intracellular Signaling Peptides and Proteins; Isoflurane; Male; Microdialysis; Microinjections; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Prosencephalon; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2006
The orexin system regulates alcohol-seeking in rats.
    British journal of pharmacology, 2006, Volume: 148, Issue:6

    Topics: Alcohol Drinking; Animals; Benzoxazoles; Conditioning, Operant; Cues; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexins; Rats; RNA, Messenger; Urea; Ventral Tegmental Area

2006
Orexin A affects ascending contraction depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum.
    Neuropharmacology, 2006, Volume: 51, Issue:3

    Topics: Acetylcholine; Animals; Arginine; Benzoxazoles; Drug Interactions; Enzyme Inhibitors; Hexamethonium; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Jejunum; Male; Mice; Mice, Inbred ICR; Models, Biological; Muscle Contraction; Naphthyridines; Neural Pathways; Neurons; Neuropeptides; Nicotinic Antagonists; Nitroarginine; Orexins; Urea

2006
Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task.
    Behavioural brain research, 2006, Oct-02, Volume: 173, Issue:1

    Topics: Analysis of Variance; Animals; Benzoxazoles; Discrimination Learning; Dose-Response Relationship, Drug; Escape Reaction; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Mental Recall; Microinjections; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Wistar; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Spatial Behavior; Urea

2006
Hypocretin-1 dose-dependently modulates maternal behaviour in mice.
    Journal of neuroendocrinology, 2006, Volume: 18, Issue:8

    Topics: Aggression; Analysis of Variance; Animals; Behavior, Animal; Benzoxazoles; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Lactation; Maternal Behavior; Mice; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Proto-Oncogene Proteins c-fos; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2006
The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10 dopamine neurons: implications for antipsychotic therapy.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:4

    Topics: Action Potentials; Analysis of Variance; Animals; Antipsychotic Agents; Benzodiazepines; Benzoxazoles; Brain; Dopamine; Drug Interactions; Haloperidol; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neurons; Neuropeptides; Olanzapine; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Time Factors; Urea

2007
Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat.
    The European journal of neuroscience, 2006, Volume: 24, Issue:10

    Topics: Action Potentials; Afferent Pathways; Animals; Benzoxazoles; Dose-Response Relationship, Drug; Drug Interactions; Facial Nerve; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neural Inhibition; Neurons; Neuropeptides; Nociceptors; Orexin Receptors; Orexins; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Skin; Trigeminal Caudal Nucleus; Trigeminal Nerve; Urea

2006
The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze.
    Peptides, 2007, Volume: 28, Issue:3

    Topics: Animals; Benzoxazoles; Dentate Gyrus; Male; Maze Learning; Memory; Microinjections; Naphthyridines; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Spatial Behavior; Swimming; Urea

2007
The effect of orexins on intestinal motility in vitro in fed and fasted rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2006, Volume: 57 Suppl 6

    Topics: Animals; Atropine; Benzoxazoles; Drug Interactions; Fasting; Gastrointestinal Motility; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Jejunum; Male; Muscle Contraction; Naphthyridines; Neuropeptides; Orexins; Random Allocation; Rats; Rats, Wistar; Tetrodotoxin; Urea

2006
Role of dorsal vagal motor nucleus orexin-receptor-1 in glycemic responses to acute versus repeated insulin administration.
    Neuropeptides, 2007, Volume: 41, Issue:2

    Topics: Animals; Benzoxazoles; Blood Glucose; Glucagon; Hypoglycemia; Hypoglycemic Agents; Insulin; Intracellular Signaling Peptides and Proteins; Male; Motor Neurons; Naphthyridines; Neuropeptides; Neurotransmitter Agents; Orexin Receptors; Orexins; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Urea; Vagus Nerve

2007
Disinhibition of perifornical hypothalamic neurones activates noradrenergic neurones and blocks pontine carbachol-induced REM sleep-like episodes in rats.
    The Journal of physiology, 2007, Jul-15, Volume: 582, Issue:Pt 2

    Topics: Animals; Benzoxazoles; Bicuculline; Carbachol; Fornix, Brain; GABA Antagonists; Hypothalamus; Injections; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neural Inhibition; Neurons; Neuropeptides; Norepinephrine; Orexin Receptors; Orexins; Pons; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep, REM; Urea

2007
Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:2

    Topics: Animals; Atropine; Benzoxazoles; Bethanechol; Bicarbonates; Cerebral Ventricles; Crosses, Genetic; Dose-Response Relationship, Drug; Duodenum; Eating; Food Deprivation; Hydrogen-Ion Concentration; Infusions, Intra-Arterial; Intestinal Mucosa; Intestinal Secretions; Intracellular Signaling Peptides and Proteins; Male; Muscarinic Agonists; Muscarinic Antagonists; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; RNA, Messenger; Time Factors; Up-Regulation; Urea

2007
Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:4

    Topics: Animals; Benzoxazoles; Dioxanes; Eating; Estrous Cycle; Female; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Gonadotropins; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Ovary; Ovulation; Pentobarbital; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; RNA, Messenger; Urea

2007
The orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptoms.
    Schizophrenia bulletin, 2007, Volume: 33, Issue:6

    Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Benzodiazepines; Benzoxazoles; Catalepsy; Haloperidol; Intracellular Signaling Peptides and Proteins; Locomotion; Male; Naphthyridines; Neuropeptides; Olanzapine; Orexins; Prolactin; Rats; Rats, Sprague-Dawley; Risperidone; Urea

2007
Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 103, Issue:5

    Topics: Animals; Benzoxazoles; Carbon Dioxide; Chemoreceptor Cells; Disease Models, Animal; Electroencephalography; Electromyography; Hypercapnia; Hypothalamus; Hypoxia; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Pulmonary Ventilation; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reflex; Time Factors; Urea; Wakefulness

2007
Food-elicited increases in cortical acetylcholine release require orexin transmission.
    Neuroscience, 2007, Nov-09, Volume: 149, Issue:3

    Topics: Acetylcholine; Animals; Benzoxazoles; Cerebral Cortex; Food; Food Deprivation; Hypothalamic Hormones; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Melanins; Microdialysis; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Pituitary Hormones; Prosencephalon; Rats; Rats, Inbred F344; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Synaptic Transmission; Urea

2007
The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task.
    Behavioural brain research, 2008, Feb-11, Volume: 187, Issue:1

    Topics: Animals; Avoidance Learning; Benzoxazoles; Data Interpretation, Statistical; Dentate Gyrus; Dimethyl Sulfoxide; Hippocampus; Male; Memory; Microinjections; Naphthyridines; Orexin Receptors; Psychomotor Performance; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2008
Role of orexin receptors in the nucleus accumbens in dopamine-dependent turning behaviour of rats.
    Neuropharmacology, 2008, Volume: 54, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzoxazoles; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Intracellular Signaling Peptides and Proteins; Male; Motor Activity; Naphthyridines; Neuropeptides; Nucleus Accumbens; Orexin Receptors; Orexins; Quinpirole; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rotation; Urea

2008
Role of the orexinergic system in acute haemorrhage in the rat.
    Neuroscience letters, 2008, Feb-20, Volume: 432, Issue:2

    Topics: Animals; Arterioles; Benzoxazoles; Blood Pressure; Catecholamines; Cerebrovascular Circulation; Heart Rate; Hypotension; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Shock, Hemorrhagic; Sympathetic Nervous System; Up-Regulation; Urea; Vasoconstriction

2008
Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats.
    British journal of pharmacology, 2008, Volume: 154, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Benzoxazoles; Caloric Restriction; Conditioning, Operant; Dietary Fats; Dose-Response Relationship, Drug; Eating; Extinction, Psychological; Feeding Behavior; Injections, Intraventricular; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Stress, Psychological; Time Factors; Urea; Yohimbine

2008
Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.
    ChemMedChem, 2008, Volume: 3, Issue:7

    Topics: Anti-HIV Agents; Benzoxazoles; Carbamates; Cell Line; Cell Survival; HIV Protease; HIV Protease Inhibitors; Humans; Lymphocytes; Methylation; Piperazine; Piperazines; Structure-Activity Relationship; Urea

2008
Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells.
    Neuroscience letters, 2008, May-09, Volume: 436, Issue:2

    Topics: Adrenal Glands; Animals; Benzoxazoles; Catecholamines; Cells, Cultured; Chromaffin Cells; Dose-Response Relationship, Drug; Electrochemistry; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Orexins; Potassium; Rats; Sympathomimetics; Urea

2008
Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell.
    Biological psychiatry, 2008, Aug-01, Volume: 64, Issue:3

    Topics: Analysis of Variance; Animals; Benzoxazoles; Intracellular Signaling Peptides and Proteins; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naphthyridines; Narcotic Antagonists; Narcotics; Neuropeptides; Nucleus Accumbens; Orexins; Proto-Oncogene Proteins c-fos; Stilbamidines; Substance Withdrawal Syndrome; Urea; Ventral Tegmental Area

2008
Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.
    Endocrinology, 2008, Volume: 149, Issue:8

    Topics: Adrenal Glands; Benzoxazoles; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Dominant; GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Peptide Fragments; Phosphoproteins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Steroids; Urea

2008
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats.
    Psychopharmacology, 2008, Volume: 199, Issue:1

    Topics: Adrenergic alpha-Antagonists; Alcoholism; Animals; Benzoxazoles; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Motivation; Motor Activity; Naphthyridines; Orexin Receptors; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Sucrose; Taste; Urea; Yohimbine

2008
Orexin-2 receptors inhibit primary afferent fiber-evoked responses of ventral roots in the neonatal rat isolated spinal cord.
    Brain research, 2008, Jul-07, Volume: 1218

    Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazoles; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Naphthyridines; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Neuropeptides; Orexin Receptors; Orexins; Protein Binding; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Spinal Cord; Spinal Nerve Roots; Urea

2008
Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
    Brain research, 2008, Aug-11, Volume: 1224

    Topics: Action Potentials; Animals; Axons; Benzoxazoles; Circadian Rhythm; Dorsomedial Hypothalamic Nucleus; Intracellular Signaling Peptides and Proteins; Locus Coeruleus; Male; Microinjections; Naphthyridines; Neural Pathways; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Synaptic Transmission; Urea; Wakefulness

2008
Orexin A attenuates unconditioned sexual motivation in male rats.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4

    Topics: Animals; Benzoxazoles; Female; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Motivation; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Ovariectomy; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sexual Behavior, Animal; Stereotaxic Techniques; Urea

2009
I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.
    Neuroscience, 2008, Dec-10, Volume: 157, Issue:4

    Topics: Analysis of Variance; Animals; Benzoxazoles; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Doublecortin Protein; Embryo, Mammalian; Exploratory Behavior; Hippocampus; Immobility Response, Tonic; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Mice; Naphthyridines; Nerve Tissue Proteins; Neurogenesis; Neuropeptide Y; Neuropeptides; Neurotransmitter Agents; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Stem Cells; Urea

2008
Orexin affects dorsal root ganglion neurons: a mechanism for regulating the spinal nociceptive processing.
    Physiological research, 2008, Volume: 57, Issue:5

    Topics: Action Potentials; Animals; Benzoxazoles; Calcium Signaling; Ganglia, Spinal; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Pain; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Synaptic Transmission; Urea

2008
Insular hypocretin transmission regulates nicotine reward.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Dec-09, Volume: 105, Issue:49

    Topics: Animals; Benzoxazoles; Cerebral Cortex; Intracellular Signaling Peptides and Proteins; Male; Motivation; Naphthyridines; Neuropeptides; Nicotine; Nicotinic Agonists; Orexin Receptors; Orexins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Self Administration; Smoking; Synaptic Transmission; Tobacco Use Disorder; Urea

2008
Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:3

    Topics: Animals; Atropine; Benzoxazoles; Biopsy; Calcium Signaling; Duodenum; Enterocytes; Fluorescent Dyes; Food Deprivation; Fura-2; Humans; In Vitro Techniques; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Parasympatholytics; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reverse Transcriptase Polymerase Chain Reaction; Urea

2009
Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus.
    Regulatory peptides, 2009, Apr-10, Volume: 154, Issue:1-3

    Topics: Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Electrophysiology; Female; Gastric Fundus; Guanethidine; Guanylate Cyclase; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthyridines; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Orexins; Oxytocin; Papaverine; Synaptic Transmission; Tetrodotoxin; Urea; Vasoactive Intestinal Peptide

2009
Orexin A decreases ketamine-induced anesthesia time in the rat: the relevance to brain noradrenergic neuronal activity.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:2

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Benzoxazoles; Brain; Cerebral Cortex; In Vitro Techniques; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Ketamine; Male; Microdialysis; Naphthyridines; Neurons; Neuropeptides; Norepinephrine; Orexins; Rats; Receptors, Neuropeptide; Urea

2009
Role of the ventromedial hypothalamic orexin-1 receptors in regulation of gastric Acid secretion in conscious rats.
    Journal of neuroendocrinology, 2009, Volume: 21, Issue:3

    Topics: Animals; Atropine; Benzoxazoles; Consciousness; Gastric Acid; Gastric Mucosa; Hypothalamus; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Parasympatholytics; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2009
Orexin type 1 receptor antagonist SB 334867 inhibits the central histamine-induced resuscitating effect in rats subjected to haemorrhagic shock.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009, Volume: 58 Suppl 1

    Topics: Animals; Benzoxazoles; Blood Pressure; Heart Rate; Histamine; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Regional Blood Flow; Resuscitation; Shock, Hemorrhagic; Urea

2009
Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness.
    The Journal of physiology, 2009, May-01, Volume: 587, Issue:Pt 9

    Topics: Animals; Benzoxazoles; Hypercapnia; Male; Naphthyridines; Neural Inhibition; Orexin Receptors; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Respiratory Center; Urea; Wakefulness

2009
The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:4

    Topics: Animals; Benzodiazepines; Benzoxazoles; Calcium Signaling; Cell Line; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Midazolam; Naphthyridines; Norepinephrine; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Transfection; Urea; Urotensins

2009
Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:9

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Benzoxazoles; Central Nervous System Depressants; Conditioning, Classical; Cues; Disease Models, Animal; Ethanol; Hypothalamus; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Substance-Related Disorders; Urea

2009
The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain.
    Neuroscience, 2009, Apr-10, Volume: 159, Issue:4

    Topics: Analgesics; Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Female; Hypothalamus; Naphthyridines; Neurons; Orexin Receptors; Pain; Pain Measurement; Posterior Horn Cells; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sciatic Neuropathy; Spinal Cord; Urea

2009
Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B.
    The Journal of endocrinology, 2009, Volume: 202, Issue:2

    Topics: Adrenal Cortex; Benzoxazoles; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; GTP-Binding Proteins; Humans; Hydrocortisone; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; p38 Mitogen-Activated Protein Kinases; Protein Isoforms; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Urea

2009
Orexin A modulates neuronal activity of the rodent suprachiasmatic nucleus in vitro.
    The European journal of neuroscience, 2009, Volume: 30, Issue:1

    Topics: Animals; Benzoxazoles; Cells, Cultured; Central Nervous System Agents; Circadian Rhythm; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sodium Channel Blockers; Suprachiasmatic Nucleus; Tetrodotoxin; Time Factors; Urea

2009
Orexins activates protein kinase C-mediated Ca(2+) signaling in isolated rat primary sensory neurons.
    Physiological research, 2010, Volume: 59, Issue:2

    Topics: Animals; Benzoxazoles; Calcium Signaling; Cells, Cultured; Ganglia, Spinal; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Neurotransmitter Agents; Nociceptors; Orexins; Pain; Protein Kinase C; Rats; Rats, Wistar; Sensory Receptor Cells; Urea

2010
Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats.
    Psychopharmacology, 2009, Volume: 206, Issue:2

    Topics: Analysis of Variance; Animals; Attention; Behavior, Animal; Benzoxazoles; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Administration Routes; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Long-Evans; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Time Factors; Urea

2009
Orexin/hypocretin is necessary for context-driven cocaine-seeking.
    Neuropharmacology, 2010, Volume: 58, Issue:1

    Topics: Analysis of Variance; Animals; Benzoxazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Extinction, Psychological; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement, Psychology; Self Administration; Time Factors; Urea

2010
Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:4

    Topics: Animals; Arousal; Behavior, Animal; Benzoxazoles; Grooming; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Midline Thalamic Nuclei; Morphine; Motor Activity; Naphthyridines; Narcotics; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sympathomimetics; Urea

2009
Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.
    The European journal of neuroscience, 2009, Volume: 30, Issue:3

    Topics: Animals; Behavior, Addictive; Benzoxazoles; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Extinction, Psychological; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement, Psychology; Signal Transduction; Urea

2009
Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol--preferring Sprague--Dawley rats.
    Alcohol (Fayetteville, N.Y.), 2009, Volume: 43, Issue:5

    Topics: Alcohol Drinking; Animals; Benzoxazoles; Ethanol; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Urea

2009
The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization.
    Neurochemistry international, 2010, Volume: 56, Issue:1

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Benzoxazoles; Dopamine; Dopamine Uptake Inhibitors; Extracellular Fluid; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Microdialysis; Naphthyridines; Neural Pathways; Neuropeptides; Nucleus Accumbens; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Synaptic Transmission; Urea

2010
Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Sep-09, Volume: 29, Issue:36

    Topics: Animals; Benzoxazoles; Choice Behavior; Cocaine-Related Disorders; Dietary Fats; Intracellular Signaling Peptides and Proteins; Male; Motivation; Naphthyridines; Neural Pathways; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement, Psychology; Urea

2009
Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents.
    Anesthesiology, 2009, Volume: 111, Issue:5

    Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Benzoxazoles; Circadian Rhythm; Halothane; Hypothalamus; Intracellular Signaling Peptides and Proteins; Isoflurane; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naphthyridines; Neuropeptides; Norepinephrine; Orexins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Urea

2009
The modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2010, Volume: 20, Issue:7

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Benzoxazoles; Biophysics; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Potentials; Mice; Mice, Inbred Strains; Naphthyridines; Neuropeptides; Neurotransmitter Agents; Orexin Receptors; Orexins; Patch-Clamp Techniques; Pyramidal Cells; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sodium Channel Blockers; Tetrodotoxin; Urea

2010
Orexins excite neurons of the rat cerebellar nucleus interpositus via orexin 2 receptors in vitro.
    Cerebellum (London, England), 2010, Volume: 9, Issue:1

    Topics: Action Potentials; Animals; Benzoxazoles; Cerebellar Nuclei; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Organ Culture Techniques; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2010
The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle.
    Respiratory physiology & neurobiology, 2010, Jan-31, Volume: 170, Issue:1

    Topics: Analysis of Variance; Animals; Benzoxazoles; Body Temperature; Chemoreceptor Cells; Circadian Rhythm; Electroencephalography; Electromyography; Hypercapnia; Male; Microdialysis; Naphthyridines; Orexin Receptors; Oxygen Consumption; Pulmonary Ventilation; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep Stages; Urea; Wakefulness

2010
Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat.
    The journal of pain, 2010, Volume: 11, Issue:6

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Aging; Animals; Benzoxazoles; Hot Temperature; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Pain; Pain Measurement; Pons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reticular Formation; Time Factors; Urea

2010
Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization.
    Brain research, 2010, Mar-04, Volume: 1317

    Topics: Animals; Benzoxazoles; Central Nervous System Agents; Cocaine; Conditioning, Classical; Dopamine Uptake Inhibitors; Female; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Mutation; Naphthyridines; Narcotics; Neuropeptides; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Space Perception; Time Factors; Urea

2010
Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
    Biological psychiatry, 2010, May-01, Volume: 67, Issue:9

    Topics: Animals; Benzoxazoles; Brain; Conditioning, Operant; Dietary Fats; Food Preferences; Ghrelin; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naphthyridines; Neuropeptides; Orexins; Proto-Oncogene Proteins c-fos; Receptors, Ghrelin; Reward; Signal Transduction; Urea

2010
The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system.
    The European journal of neuroscience, 2010, Volume: 31, Issue:2

    Topics: Animals; Benzoxazoles; Cocaine; Dopamine; Electrochemistry; Intracellular Signaling Peptides and Proteins; Limbic System; Male; Mesencephalon; Mice; Microdialysis; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Signal Transduction; Urea

2010
Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Feb-10, Volume: 30, Issue:6

    Topics: Animals; Anxiety; Arginine Vasopressin; Behavior, Addictive; Benzoxazoles; Conditioning, Operant; Corticotropin-Releasing Hormone; Extinction, Psychological; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naphthyridines; Neurons; Neuropeptides; Nicotine; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Tobacco Use Disorder; Urea

2010
The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats.
    Neuroscience, 2010, Apr-28, Volume: 167, Issue:1

    Topics: Animals; Benzoxazoles; Brain; Cacao; Central Nervous System Agents; Cues; Dietary Fats; Eating; Feeding Behavior; Food; Intracellular Signaling Peptides and Proteins; Male; Motivation; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Urea

2010
Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA.
    Psychopharmacology, 2010, Volume: 209, Issue:2

    Topics: Acetamides; Animals; Arcuate Nucleus of Hypothalamus; Behavior, Animal; Benzoxazoles; Dose-Response Relationship, Drug; Hypothalamic Area, Lateral; Hypothalamus; Infusions, Intravenous; Intracellular Signaling Peptides and Proteins; Isoquinolines; Male; Naphthyridines; Neuropeptides; Nicotine; Nicotinic Agonists; Orexin Receptors; Orexins; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement, Psychology; RNA, Messenger; Self Administration; Urea

2010
Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement.
    Biological psychiatry, 2010, Apr-15, Volume: 67, Issue:8

    Topics: Animals; Benzoxazoles; Conditioning, Operant; Data Interpretation, Statistical; Food; Hypothalamic Area, Lateral; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Receptors, Neuropeptide; Reinforcement Schedule; Reinforcement, Psychology; RNA Interference; Urea; Viruses

2010
Endogenous orexin-A modulates gastric motility by peripheral mechanisms in rats.
    Peptides, 2010, Volume: 31, Issue:6

    Topics: Animals; Benzoxazoles; Fasting; Gastric Emptying; Gastrointestinal Motility; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Up-Regulation; Urea; Vagus Nerve

2010
Opposite roles of dopamine and orexin in quinpirole-induced excessive drinking: a rat model of psychotic polydipsia.
    Psychopharmacology, 2010, Volume: 211, Issue:3

    Topics: Animals; Benzoxazoles; Cerebral Cortex; Conditioning, Operant; Corticosterone; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drinking; Drug Synergism; Haloperidol; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexins; Psychotic Disorders; Quinpirole; Rats; Rats, Sprague-Dawley; Urea

2010
Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system.
    Addiction biology, 2011, Volume: 16, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Alcoholism; Animals; Benzoxazoles; Dopamine; Ghrelin; Limbic System; Male; Mesencephalon; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Naphthyridines; Narcotic Antagonists; Nerve Net; Nucleus Accumbens; Orexin Receptors; Peptide Hormones; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide; Signal Transduction; Urea; Ventral Tegmental Area

2011
Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats.
    Neuroscience letters, 2010, Oct-04, Volume: 482, Issue:3

    Topics: Animals; Benzoxazoles; Injections, Intraventricular; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naloxone; Naphthyridines; Narcotic Antagonists; Narcotics; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Substance Withdrawal Syndrome; Urea

2010
The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat.
    Endocrinology, 2010, Volume: 151, Issue:9

    Topics: Adipose Tissue, Brown; Animals; Benzoxazoles; Blotting, Western; Body Weight; Eating; Energy Metabolism; Hypothalamic Hormones; Ion Channels; Male; Melanins; Melanocyte-Stimulating Hormones; Mitochondrial Proteins; Naphthyridines; Orexin Receptors; Piperidines; Pituitary Hormones; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thermogenesis; Uncoupling Protein 1; Urea

2010
Central orexin-A increases gastric motility in rats.
    Peptides, 2010, Volume: 31, Issue:11

    Topics: Animals; Benzoxazoles; Gastric Emptying; Gastrointestinal Motility; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexins; Postprandial Period; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Urea

2010
Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.
    Behavioural brain research, 2011, Jan-01, Volume: 216, Issue:1

    Topics: Analysis of Variance; Animals; Benzoxazoles; Dentate Gyrus; Electric Stimulation; Electrophysiology; Long-Term Potentiation; Male; Naphthyridines; Neurons; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Synapses; Urea

2011
Chemical stimulation of the lateral hypothalamus induces conditioned place preference in rats: Involvement of OX1 and CB1 receptors in the ventral tegmental area.
    Behavioural brain research, 2011, Feb-02, Volume: 217, Issue:1

    Topics: Animals; Benzoxazoles; Carbachol; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Hypothalamic Area, Lateral; Male; Naphthyridines; Neural Pathways; Orexin Receptors; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Urea; Ventral Tegmental Area

2011
Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.
    Physiology & behavior, 2011, Jan-10, Volume: 102, Issue:1

    Topics: Animals; Avoidance Learning; Benzoxazoles; Conditioning, Classical; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Midline Thalamic Nuclei; Morphine; Naloxone; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Substance Withdrawal Syndrome; Urea

2011
Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin₁ receptors.
    British journal of pharmacology, 2011, Volume: 162, Issue:4

    Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Benzoxazoles; Brain; Conditioning, Operant; Cues; Male; Naphthyridines; Nerve Tissue Proteins; Neurons; Orexin Receptors; Organ Specificity; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Temperance; Urea

2011
Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.
    British journal of pharmacology, 2011, Volume: 162, Issue:4

    Topics: Anesthesia, Spinal; Animals; Baroreflex; Benzoxazoles; Evoked Potentials, Somatosensory; Injections, Spinal; Intracellular Signaling Peptides and Proteins; Kinetics; Male; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Peripheral Nervous System; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Respiration; Splanchnic Nerves; Sympathetic Nervous System; Tachycardia; Urea; Vagotomy

2011
Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness.
    Sleep, 2010, Volume: 33, Issue:10

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazoles; Bicuculline; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Intracellular Signaling Peptides and Proteins; Isotonic Solutions; Male; Microinjections; Naphthyridines; Neuropeptides; Orexins; Pons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reticular Formation; Ringer's Solution; Sleep Stages; Urea; Wakefulness

2010
Involvement of the orexin/hypocretin system in ethanol conditioned place preference.
    Psychopharmacology, 2011, Volume: 214, Issue:4

    Topics: Animals; Behavior, Animal; Benzoxazoles; Conditioning, Classical; Drug-Seeking Behavior; Ethanol; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred DBA; Motor Activity; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Self Administration; Urea

2011
Effects of orexin-A on propofol anesthesia in rats.
    Journal of anesthesia, 2011, Volume: 25, Issue:1

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Benzoxazoles; Dopamine; Electroencephalography; Infusions, Intravenous; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Microdialysis; Naphthyridines; Neuropeptides; Norepinephrine; Orexin Receptors; Orexins; Postural Balance; Prefrontal Cortex; Propofol; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reflex; Urea

2011
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
    British journal of pharmacology, 2011, Volume: 162, Issue:6

    Topics: Alkyl and Aryl Transferases; Benzoxazoles; Cell Line; Cell Membrane; Cloning, Molecular; Cyclohexanols; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phenylurea Compounds; Phosphorylation; Piperidines; Plasmids; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rimonabant; Thiazoles; Urea

2011
Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward.
    Behavioural pharmacology, 2011, Volume: 22, Issue:2

    Topics: Animals; Behavior, Animal; Benzoxazoles; Cocaine; Conditioning, Operant; Cues; Dextroamphetamine; Discrimination Learning; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement Schedule; Reward; Self Administration; Urea

2011
SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:3

    Topics: Animals; Avoidance Learning; Benzoxazoles; Body Weight; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Taste; Urea

2011
A role for orexin in central vestibular motor control.
    Neuron, 2011, Feb-24, Volume: 69, Issue:4

    Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzoxazoles; Drug Interactions; Electric Stimulation; Exploratory Behavior; Hindlimb Suspension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Potentials; Microinjections; Motor Activity; Naphthyridines; Neurons; Neuropeptides; Orexins; Patch-Clamp Techniques; Psychomotor Performance; Rats; Receptors, Neuropeptide; Sodium-Calcium Exchanger; Thiourea; Urea; Vestibular Nucleus, Lateral

2011
Intraventricular administration of neuropeptide S has reward-like effects.
    European journal of pharmacology, 2011, May-01, Volume: 658, Issue:1

    Topics: Animals; Behavior, Animal; Benzazepines; Benzoxazoles; Conditioning, Psychological; Dopamine Antagonists; Injections, Intraventricular; Locomotion; Male; Naphthyridines; Neuropeptides; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Neuropeptide; Reward; Self Administration; Urea

2011
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.
    Behavioural brain research, 2011, Sep-23, Volume: 222, Issue:2

    Topics: Animals; Anxiety; Benzoxazoles; Choice Behavior; Depression; Disease Models, Animal; Immobility Response, Tonic; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naphthyridines; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Swimming; Urea

2011
Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period.
    Behavioural brain research, 2011, Aug-01, Volume: 221, Issue:1

    Topics: Animals; Animals, Newborn; Benzoxazoles; Disease Models, Animal; Drug Interactions; Ethanol; Homing Behavior; Hyperkinesis; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2011
The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats.
    Brain research, 2011, May-19, Volume: 1391

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazoles; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Male; Motivation; Naphthyridines; Orexin Receptors; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Sucrose; Time Factors; Urea

2011
Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.
    The international journal of neuropsychopharmacology, 2011, Volume: 14, Issue:5

    Topics: Animals; Benzoxazoles; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Extinction, Psychological; Male; Motor Activity; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Thalamus; Urea; Ventral Tegmental Area

2011
Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2011, May-15, Volume: 21, Issue:10

    Topics: Benzoxazoles; Drug Delivery Systems; Ligands; Molecular Structure; Naphthyridines; Orexin Receptors; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Structure-Activity Relationship; Urea

2011
The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
    Neuroscience letters, 2011, Jul-08, Volume: 498, Issue:2

    Topics: Animals; Benzoxazoles; Blood Pressure; Body Temperature Regulation; Dinoprostone; Heart Rate; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Muscimol; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2011
Stimulatory effect of intracerebroventricular administration of orexin A on food intake in the zebrafish, Danio rerio.
    Peptides, 2011, Volume: 32, Issue:7

    Topics: Animals; Benzoxazoles; Eating; Fasting; Feeding Behavior; Hypothalamus; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urea; Zebrafish

2011
OX1 orexin/hypocretin receptor activation of phospholipase D.
    British journal of pharmacology, 2012, Volume: 165, Issue:4b

    Topics: Acetophenones; Animals; Benzopyrans; Benzoxazoles; CHO Cells; Cricetinae; Cricetulus; Humans; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phospholipase D; Protein Kinase C-delta; Protein Kinase Inhibitors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Tetradecanoylphorbol Acetate; Urea

2012
Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats.
    Cellular immunology, 2011, Volume: 271, Issue:1

    Topics: Animals; Benzoxazoles; Chondrus; Exudates and Transudates; Fasting; Inflammation; Intracellular Signaling Peptides and Proteins; Macrophages, Peritoneal; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phagocytosis; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Time Factors; Urea

2011
Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.
    Biological psychiatry, 2012, Feb-01, Volume: 71, Issue:3

    Topics: Animals; Antigens, Surface; Benzoxazoles; Intracellular Signaling Peptides and Proteins; Isoquinolines; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Molecular Imaging; Naphthyridines; Neuroanatomical Tract-Tracing Techniques; Neuropeptides; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Substance Withdrawal Syndrome; Tobacco Use Disorder; Urea

2012
Arousal effects of orexin A on acute alcohol intoxication-induced coma in rats.
    Neuropharmacology, 2012, Volume: 62, Issue:2

    Topics: Alcoholic Intoxication; Animals; Arousal; Benzoxazoles; Brain; Coma; Consciousness; Electroencephalography; Ethanol; Female; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neurons; Neuropeptides; Orexins; Prazosin; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide; Ritanserin; Urea

2012
Evidence for the role of hindbrain orexin-1 receptors in the control of meal size.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:6

    Topics: Animals; Benzoxazoles; Eating; Intracellular Signaling Peptides and Proteins; Islet Amyloid Polypeptide; Male; Motor Activity; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Photoperiod; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rhombencephalon; Satiation; Urea

2011
Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Oct-12, Volume: 31, Issue:41

    Topics: Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Benzoxazoles; Biphenyl Compounds; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Estrenes; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Intracellular Signaling Peptides and Proteins; Lactones; Male; Morpholines; Naphthalenes; Naphthyridines; Neural Inhibition; Neural Pathways; Neuropeptides; Orexin Receptors; Orexins; Orlistat; Pain; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2011
Effects of orexin and glucose microinjected into the hypothalamic paraventricular nucleus on gastric acid secretion in conscious rats.
    Neurogastroenterology and motility, 2012, Volume: 24, Issue:2

    Topics: Animals; Benzoxazoles; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Glucose; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Naphthyridines; Neuropeptides; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Urea

2012
The influence of orexins on the firing rate and pattern of rat intergeniculate leaflet neurons--electrophysiological and immunohistological studies.
    The European journal of neuroscience, 2011, Volume: 34, Issue:9

    Topics: Action Potentials; Age Factors; Animals; Benzoxazoles; Enkephalins; Geniculate Bodies; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neurons; Neuropeptide Y; Neuropeptides; Orexins; Rats; Rats, Wistar; Synaptophysin; Urea

2011
An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-02, Volume: 31, Issue:44

    Topics: Adipose Tissue, Brown; Animals; Benzoxazoles; beta-Galactosidase; Body Temperature; Cholera Toxin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gene Transfer Techniques; Globus Pallidus; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Microinjections; N-Methylaspartate; Naphthyridines; Neurons; Neuropeptides; Neurotransmitter Agents; Orexins; Polystyrenes; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thermogenesis; Urea

2011
Mapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras.
    Neuroscience letters, 2012, Jan-06, Volume: 506, Issue:1

    Topics: Benzoxazoles; Binding Sites; Chimera; HEK293 Cells; Humans; Inositol Phosphates; Models, Molecular; Naphthyridines; Orexin Receptors; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Transfection; Tritium; Urea

2012
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Adipocytes; Animals; Antineoplastic Agents; Benzoxazoles; Body Weight; Calorimetry; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Partial Agonism; Drug Screening Assays, Antitumor; Fibric Acids; Fibroblasts; Gene Expression Profiling; Humans; Insulin Resistance; Intra-Abdominal Fat; Liver; Mice; Mice, Inbred C57BL; Models, Molecular; PPAR alpha; PPAR gamma; Propionates; Stereoisomerism; Structure-Activity Relationship; Urea

2012
Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.
    Brain research, 2012, Jan-11, Volume: 1431

    Topics: Animals; Benzoxazoles; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Male; Mice; Motor Activity; Naphthyridines; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement Schedule; Reward; Self Administration; Urea

2012
Orexin-1 receptor mediation of cocaine seeking in male and female rats.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:3

    Topics: Animals; Benzoxazoles; Cocaine-Related Disorders; Cues; Extinction, Psychological; Female; Male; Motor Activity; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Sex Characteristics; Urea; Yohimbine

2012
Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking.
    The European journal of neuroscience, 2012, Volume: 35, Issue:5

    Topics: Animals; Behavior, Addictive; Benzoxazoles; Conditioning, Operant; Cues; Heroin; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Urea

2012
The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress.
    Physiology & behavior, 2012, Dec-05, Volume: 107, Issue:5

    Topics: Animals; Benzoxazoles; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Male; Methamphetamine; Muscimol; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Stress, Psychological; Sympathetic Nervous System; Urea

2012
Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats.
    Psychopharmacology, 2013, Volume: 226, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoxazoles; Cocaine; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide; Self Administration; Signal Transduction; Urea; Ventral Tegmental Area

2013
Orexin receptor type-1 antagonist SB-334867 inhibits the development of morphine analgesic tolerance in rats.
    Peptides, 2012, Volume: 35, Issue:1

    Topics: Analgesics, Opioid; Animals; Benzoxazoles; Drug Tolerance; Male; Morphine; Naphthyridines; Nociception; Orexin Receptors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2012
Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:8

    Topics: Animals; Anxiety; Benzoxazoles; Bradycardia; Disease Models, Animal; Hypercapnia; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Respiration; Urea

2012
A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Mar-28, Volume: 32, Issue:13

    Topics: Animals; Baclofen; Benzoxazoles; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Morpholinos; Muscimol; Naphthyridines; Neural Pathways; Neuroanatomical Tract-Tracing Techniques; Neurons; Neuropeptides; Orexins; Rats; Rats, Sprague-Dawley; Septum of Brain; Urea

2012
OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release.
    Molecular pharmacology, 2012, Volume: 82, Issue:2

    Topics: Animals; Arachidonic Acid; Benzoxazoles; Cannabinoid Receptor Modulators; CHO Cells; Cricetinae; Cricetulus; Endocannabinoids; HEK293 Cells; Humans; Naphthyridines; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Urea

2012
Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells.
    Regulatory peptides, 2012, Oct-10, Volume: 178, Issue:1-3

    Topics: Animals; Benzoxazoles; Cells, Cultured; Diethylstilbestrol; Dioxanes; Estradiol; Estrogens, Non-Steroidal; Female; Gene Expression; Granulosa Cells; Intracellular Signaling Peptides and Proteins; Luteal Cells; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Ovary; Phenylurea Compounds; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2012
Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Aminopyridines; Animals; Benzoxazoles; Dose-Response Relationship, Drug; GABA Agonists; Male; Naphthyridines; Orexin Receptors; Phenylurea Compounds; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep; Sulfonamides; Urea

2012
N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking.
    Addiction biology, 2014, Volume: 19, Issue:2

    Topics: Analysis of Variance; Animals; Benzoxazoles; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Ethanol; Intracellular Signaling Peptides and Proteins; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexins; Rats; Reinforcement, Psychology; Reward; Secondary Prevention; Self Administration; Sweetening Agents; Urea

2014
Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:2

    Topics: Analgesia; Animals; Benzoxazoles; Formaldehyde; Immobilization; Naloxone; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Stress, Physiological; Swimming; Urea

2012
Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats.
    Neuropharmacology, 2012, Volume: 63, Issue:7

    Topics: Animals; Benzoxazoles; Cocaine; Drug-Seeking Behavior; Extinction, Psychological; Male; Naphthyridines; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Self Administration; Urea

2012
Putative genes mediating the effects of orexins in the posterior paraventricular thalamus on neuroendocrine and behavioral adaptations to repeated stress.
    Brain research bulletin, 2012, Dec-01, Volume: 89, Issue:5-6

    Topics: Adaptation, Psychological; Animals; bcl-2-Associated X Protein; Benzoxazoles; Intracellular Signaling Peptides and Proteins; Male; Midline Thalamic Nuclei; Naphthyridines; Neuropeptides; Neurosecretory Systems; Orexins; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Recurrence; Stress, Psychological; Urea; Vascular Endothelial Growth Factor A

2012
The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice.
    Behavioural brain research, 2013, Jan-15, Volume: 237

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antigens, Surface; Benzoxazoles; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Isoquinolines; Male; Mice; Morphine; Morphine Dependence; Naphthyridines; Orexin Receptors; Pyridines; Receptors, Cell Surface; Receptors, Neuropeptide; Urea

2013
Blockade of orexin receptor 1 attenuates the development of morphine tolerance and physical dependence in rats.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:2

    Topics: Animals; Benzoxazoles; Drug Tolerance; Male; Morphine; Naphthyridines; Opioid-Related Disorders; Orexin Receptors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2012
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.
    Bioorganic & medicinal chemistry letters, 2012, Nov-01, Volume: 22, Issue:21

    Topics: Benzoxazoles; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Ligands; Molecular Structure; Naphthyridines; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2012
Role of orexin/hypocretin in conditioned sucrose-seeking in rats.
    Psychopharmacology, 2013, Volume: 226, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazoles; Conditioning, Operant; Drug-Seeking Behavior; Extinction, Psychological; Food Deprivation; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neurons; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reinforcement Schedule; Reward; Self Administration; Sucrose; Urea

2013
Orexin-1 receptor antagonism fails to reduce anxiety-like behaviour in either plus-maze-naïve or plus-maze-experienced mice.
    Behavioural brain research, 2013, Apr-15, Volume: 243

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzoxazoles; Chlordiazepoxide; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Mice; Naphthyridines; Neuropeptides; Neuropsychological Tests; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Urea

2013
Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist.
    Psychopharmacology, 2013, Volume: 228, Issue:3

    Topics: Animals; Behavior, Animal; Benzoxazoles; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Food Deprivation; Male; Naphthyridines; Orexin Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reward; Saccharin; Self Administration; Urea

2013
A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:9

    Topics: Animals; Benzoxazoles; Conditioning, Operant; Cues; Drug-Seeking Behavior; Extinction, Psychological; Hypothalamus; Isoquinolines; Male; Mice; Microinjections; Naphthyridines; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Prefrontal Cortex; Protein Kinase Inhibitors; Pyridines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Signal Transduction; Urea

2013
Blockade of central orexin 2 receptors reduces arterial pressure in spontaneously hypertensive rats.
    Experimental physiology, 2013, Volume: 98, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Arterial Pressure; Benzoxazoles; Cardiovascular System; Heart Rate; Immunoglobulin G; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Inbred SHR; Solitary Nucleus; Urea

2013
Functional inactivation of orexin 1 receptors in the cerebellum disrupts trace eyeblink conditioning and local theta oscillations in guinea pigs.
    Behavioural brain research, 2013, Aug-01, Volume: 250

    Topics: Analysis of Variance; Animals; Benzoxazoles; Blinking; Cerebellum; Complement Pathway, Classical; Guinea Pigs; Male; Microinjections; Naphthyridines; Orexin Receptors; Purkinje Cells; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Theta Rhythm; Time Factors; Urea

2013
Behavioral characteristics and pharmacological manipulations of a nicotine-entrainable circadian oscillator.
    Chronobiology international, 2013, Volume: 30, Issue:7

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzoxazoles; Circadian Rhythm; Feeding Behavior; Female; Fructose; Light; Motor Activity; Naltrexone; Naphthyridines; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Oscillometry; Rats; Rats, Sprague-Dawley; Time Factors; Topiramate; Urea

2013
Pentylenetetrazol-induced seizures are exacerbated by sleep deprivation through orexin receptor-mediated hippocampal cell proliferation.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35, Issue:2

    Topics: Animals; Benzoxazoles; CA3 Region, Hippocampal; Cell Proliferation; Convulsants; Dentate Gyrus; Hippocampus; Intracellular Signaling Peptides and Proteins; Isoquinolines; Male; Naphthyridines; Neurons; Neuropeptides; Neuroprotective Agents; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Pyridines; Rats; Rats, Wistar; Seizures; Sleep Deprivation; Time Factors; Urea

2014
The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward.
    Biological psychiatry, 2014, Mar-15, Volume: 75, Issue:6

    Topics: Animals; Benzoxazines; Benzoxazoles; Cannabinoid Receptor Agonists; Cannabinoids; Conditioning, Operant; Dopamine; Dronabinol; Hypothalamic Area, Lateral; Male; Marijuana Abuse; Mice; Mice, Knockout; Molecular Targeted Therapy; Morpholines; Naphthalenes; Naphthyridines; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Proto-Oncogene Proteins c-fos; Reinforcement Schedule; Reward; Self Administration; Urea

2014
Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats.
    Psychopharmacology, 2014, Volume: 231, Issue:2

    Topics: Animals; Benzoxazoles; Choice Behavior; Conditioning, Operant; Eating; Infusions, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; Reinforcement Schedule; Rhombencephalon; Solitary Nucleus; Urea

2014
Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 112

    Topics: Analgesics; Animals; Benzoxazoles; Injections, Intraventricular; Morphine; Naphthyridines; Orexin Receptor Antagonists; Pain Measurement; Rats; Receptors, Neuropeptide; Urea

2013
Mechanisms underlying obesity resistance associated with high spontaneous physical activity.
    Neuroscience, 2014, Jan-03, Volume: 256

    Topics: Age Factors; Animals; Benzazepines; Benzoxazoles; Body Weight; Dopamine Antagonists; Eating; Electromyography; Eye Movements; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Motor Activity; Naphthyridines; Neuropeptides; Obesity; Orexin Receptor Antagonists; Orexins; Rats; Rats, Sprague-Dawley; Sleep; Substantia Nigra; Urea; Wakefulness

2014
Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Dec-10, Volume: 110, Issue:50

    Topics: Acoustic Stimulation; Amygdala; Animals; Benzoxazoles; Channelrhodopsins; Conditioning, Classical; Fear; Intracellular Signaling Peptides and Proteins; Learning; Locus Coeruleus; Male; Naphthyridines; Neuropeptides; Optogenetics; Orexins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Urea

2013
Hypocretin (orexin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:5

    Topics: Animals; Benzoxazoles; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Interneurons; Mice; Mice, Inbred Strains; Naphthyridines; Neural Inhibition; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Receptors, Ionotropic Glutamate; Synaptic Transmission; Tissue Culture Techniques; Urea; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2

2015
Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis.
    Peptides, 2014, Volume: 54

    Topics: Animals; Benzoxazoles; Doublecortin Protein; Enzyme Activation; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Memory; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthyridines; Neurogenesis; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Rats, Wistar; Spatial Learning; Urea

2014
The orexin-1 receptor antagonist SB-334867 attenuates anxiety in rats exposed to cat odor but not the elevated plus maze: an investigation of Trial 1 and Trial 2 effects.
    Hormones and behavior, 2014, Volume: 65, Issue:3

    Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Benzoxazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Naphthyridines; Odorants; Orexin Receptor Antagonists; Rats; Rats, Wistar; Recognition, Psychology; Stress, Psychological; Urea

2014
Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking.
    Neuroreport, 2014, May-07, Volume: 25, Issue:7

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Benzoxazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Reward; Self Administration; Sweetening Agents; Urea

2014
Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Analysis of Variance; Animals; Benzoxazoles; Diet, High-Fat; Dietary Fats; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Limbic System; Mice; Naphthyridines; Neural Pathways; Neuroanatomical Tract-Tracing Techniques; Neurons; Neuropeptides; Orexins; Proto-Oncogene Proteins c-fos; Reward; Signal Transduction; Urea; Ventral Tegmental Area

2014
Central orexin inhibits reflex swallowing elicited by the superior laryngeal nerve via caudal brainstem in the rat.
    Physiology & behavior, 2014, May-10, Volume: 130

    Topics: Animals; Benzoxazoles; Brain Stem; Central Nervous System Agents; Deglutition; Electric Stimulation; Electromyography; Intracellular Signaling Peptides and Proteins; Laryngeal Nerves; Male; Muscle, Skeletal; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats, Sprague-Dawley; Reflex; Solitary Nucleus; Urea

2014
Ghrelin acts as an interface between physiological state and phasic dopamine signaling.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Apr-02, Volume: 34, Issue:14

    Topics: Action Potentials; Animals; Benzoxazoles; Dopamine; Dose-Response Relationship, Drug; Fasting; Feeding Behavior; Ghrelin; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neural Pathways; Neuropeptides; Nucleus Accumbens; Oligopeptides; Orexins; Rats; Rats, Sprague-Dawley; Signal Transduction; Urea; Ventral Tegmental Area; Wakefulness

2014
Circadian rhythm disruption by a novel running wheel: roles of exercise and arousal in blockade of the luteinizing hormone surge.
    Physiology & behavior, 2014, May-28, Volume: 131

    Topics: Animals; Arousal; Benzoxazoles; Central Nervous System Agents; Circadian Rhythm; Darkness; Estrus; Female; Gonadotropin-Releasing Hormone; Housing, Animal; Luteinizing Hormone; Mesocricetus; Motor Activity; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Photoperiod; Proestrus; Proto-Oncogene Proteins c-fos; Urea

2014
Hepatic branch vagus nerve plays a critical role in the recovery of post-ischemic glucose intolerance and mediates a neuroprotective effect by hypothalamic orexin-A.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Benzoxazoles; Choline O-Acetyltransferase; Glucose Intolerance; Hypothalamus; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Liver; Male; Mice; Naphthyridines; Neuropeptides; Neuroprotective Agents; Orexin Receptors; Orexins; Proto-Oncogene Proteins c-fos; Urea; Vagus Nerve

2014
Blockade of orexin-1 receptors in the ventral tegmental area could attenuate the lateral hypothalamic stimulation-induced potentiation of rewarding properties of morphine.
    Neuropeptides, 2014, Volume: 48, Issue:3

    Topics: Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Conditioning, Psychological; Hypothalamic Area, Lateral; Male; Morphine; Motor Activity; Naphthyridines; Narcotics; Orexin Receptor Antagonists; Rats; Rats, Wistar; Reward; Urea; Ventral Tegmental Area

2014
Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes.
    International journal of molecular medicine, 2014, Volume: 34, Issue:1

    Topics: Animals; Apoptosis; Benzoxazoles; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Everolimus; Forkhead Transcription Factors; Gene Expression Regulation; Hepatocytes; Intracellular Signaling Peptides and Proteins; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Naphthyridines; Nerve Tissue Proteins; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidines; Quinolones; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Urea

2014
Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.
    Neuroscience, 2014, Jul-11, Volume: 272

    Topics: Animals; Anxiety; Behavior, Animal; Benzoxazoles; Circadian Rhythm; Depression; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Light; Male; Motor Activity; Naphthyridines; Neuropeptides; Orexins; Photoperiod; Phototherapy; Rats; Seasonal Affective Disorder; Signal Transduction; Urea

2014
Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats.
    Neuroscience letters, 2014, Jul-25, Volume: 576

    Topics: Animals; Benzoxazoles; Drinking; Eating; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Octreotide; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Peptide Fragments; Rats, Sprague-Dawley; Receptors, Somatostatin; Somatostatin; Urea

2014
The hypocretin/orexin system mediates the extinction of fear memories.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:12

    Topics: Amygdala; Animals; Benzoxazoles; Extinction, Psychological; Fear; Hippocampus; Intracellular Signaling Peptides and Proteins; Isoquinolines; Male; Memory; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Pyridines; Urea

2014
Orexin A enhances locomotor activity and induces anxiogenic-like action in the goldfish, Carassius auratus.
    Hormones and behavior, 2014, Volume: 66, Issue:2

    Topics: Animals; Anxiety; Benzoxazoles; Carbolines; Diazepam; Emotions; Goldfish; Hypnotics and Sedatives; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Motor Activity; Naphthyridines; Neuropeptides; Orexins; Urea

2014
Blockade of orexin type-1 receptors in locus coeruleus nucleus attenuates the development of morphine dependency in rats.
    Neuroscience letters, 2014, Aug-22, Volume: 578

    Topics: Animals; Benzoxazoles; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Urea

2014
Binge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL/6J mice: pharmacological and molecular evidence of orexin involvement.
    Behavioural brain research, 2014, Oct-01, Volume: 272

    Topics: Animals; Benzoxazoles; Bulimia; Dietary Sucrose; Dose-Response Relationship, Drug; Drinking Behavior; Drinking Water; Energy Intake; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Motor Activity; Naphthyridines; Neuropeptides; Neurotransmitter Agents; Nuclear Proteins; Orexins; RNA, Messenger; Saccharin; Urea

2014
Blockade of orexin type 1 receptors inhibits the development of morphine tolerance in lateral paragigantocellularis nucleus: an electrophysiological approach.
    Brain research, 2014, Aug-26, Volume: 1578

    Topics: Animals; Benzoxazoles; Drug Tolerance; Male; Medulla Oblongata; Morphine; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Urea

2014
Role of orexin/hypocretin in conditioned sucrose-seeking in female rats.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Appetitive Behavior; Benzoxazoles; Central Nervous System Agents; Conditioning, Operant; Cues; Dietary Sucrose; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Food Deprivation; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats, Sprague-Dawley; Reward; Self Administration; Sex Characteristics; Spatial Behavior; Urea

2014
Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry.
    Molecular and cellular neurosciences, 2014, Volume: 62

    Topics: Action Potentials; Animals; Benzoxazoles; Glucose; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Male; Mesencephalon; Mice, Inbred C57BL; Naphthyridines; Neurons; Neuropeptides; Orexins; Reward; Synaptic Transmission; Urea; Ventral Tegmental Area

2014
Perifornical hypothalamic orexin and serotonin modulate the counterregulatory response to hypoglycemic and glucoprivic stimuli.
    Diabetes, 2015, Volume: 64, Issue:1

    Topics: Animals; Astrocytes; Benzoxazoles; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fornix, Brain; Hypoglycemia; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Midline Thalamic Nuclei; Naphthyridines; Neurons; Neuropeptides; Orexins; Paraventricular Hypothalamic Nucleus; Rats, Sprague-Dawley; Receptors, Neuropeptide; Serotonin; Urea; Ventromedial Hypothalamic Nucleus

2015
Orexin-1 receptor antagonist in central nucleus of the amygdala attenuates the acquisition of flavor-taste preference in rats.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 126

    Topics: Animals; Avoidance Learning; Benzoxazoles; Central Amygdaloid Nucleus; Food Preferences; Lithium Chloride; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Saccharin; Taste Perception; Urea

2014
Orexin-A stimulates 3β-hydroxysteroid dehydrogenase expression and cortisol production in H295R human adrenocortical cells through the AKT pathway.
    International journal of molecular medicine, 2014, Volume: 34, Issue:6

    Topics: 3-Hydroxysteroid Dehydrogenases; Adrenocortical Carcinoma; Benzoxazoles; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydrocortisone; Intracellular Signaling Peptides and Proteins; Isoenzymes; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Urea

2014
Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX 2 receptors.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:6

    Topics: Action Potentials; Animals; Benzoxazoles; Dose-Response Relationship, Drug; Isoquinolines; Naphthyridines; Neurons; Neurotransmitter Agents; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pyridines; Rats, Sprague-Dawley; RNA, Messenger; Sodium Channel Blockers; Tetrodotoxin; Tissue Culture Techniques; Urea; Vestibular Nuclei

2015
Role of intra-hippocampal orexin 1 and orexin 2 receptors in conditioned place preference induced by chemical stimulation of the lateral hypothalamus.
    Behavioural brain research, 2015, Feb-15, Volume: 279

    Topics: Animals; Benzoxazoles; CA1 Region, Hippocampal; Carbachol; Cholinergic Agonists; Conditioning, Psychological; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Stimulation, Chemical; Urea

2015
The orexin-1 receptor antagonist SB-334867 decreases anxiety-like behavior and c-Fos expression in the hypothalamus of rats exposed to cat odor.
    Behavioural brain research, 2015, Feb-01, Volume: 278

    Topics: Analysis of Variance; Animals; Anxiety; Benzoxazoles; Cats; Disease Models, Animal; Gene Expression Regulation; Hypothalamus; Male; Naphthyridines; Odorants; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Wistar; Receptors, Neuropeptide; Urea

2015
Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.
    ACS chemical neuroscience, 2015, Jan-21, Volume: 6, Issue:1

    Topics: Analysis of Variance; Animals; Benzoxazoles; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrochemical Techniques; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Self Administration; Signal Transduction; Urea

2015
Antinociceptive action against colonic distension by brain orexin in conscious rats.
    Brain research, 2015, Feb-19, Volume: 1598

    Topics: Analgesics; Animals; Benzoxazoles; Brain; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Intracellular Signaling Peptides and Proteins; Male; Morphine; Naphthyridines; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pain Threshold; Physical Stimulation; Rats, Sprague-Dawley; Urea; Visceral Pain

2015
Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 130

    Topics: Animals; Benzoxazoles; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pentylenetetrazole; Pyridines; Rats; Seizures; Urea

2015
Binge-like consumption of ethanol and other salient reinforcers is blocked by orexin-1 receptor inhibition and leads to a reduction of hypothalamic orexin immunoreactivity.
    Alcoholism, clinical and experimental research, 2015, Volume: 39, Issue:1

    Topics: Animals; Benzoxazoles; Binge Drinking; Dose-Response Relationship, Drug; Hypothalamic Area, Lateral; Male; Mice; Motor Activity; Naphthyridines; Orexin Receptors; Orexins; Reinforcement, Psychology; Saccharin; Sucrose; Urea

2015
The electrical activity of hippocampal pyramidal neuron is subjected to descending control by the brain orexin/hypocretin system.
    Neurobiology of learning and memory, 2015, Volume: 119

    Topics: Action Potentials; Animals; Benzoxazoles; Carbachol; Hippocampus; Hypothalamic Area, Lateral; Infusions, Intraventricular; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pyramidal Cells; Rats; Rats, Wistar; Urea

2015
Orexin-1 receptor signaling increases motivation for cocaine-associated cues.
    The European journal of neuroscience, 2015, Volume: 41, Issue:9

    Topics: Animals; Benzoxazoles; Cocaine-Related Disorders; Cues; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Signal Transduction; Urea

2015
Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference.
    Addiction biology, 2016, Volume: 21, Issue:3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzoxazoles; Choice Behavior; Conditioning, Psychological; Dentate Gyrus; Disease Models, Animal; Hypothalamic Area, Lateral; Male; Morphine; Naphthyridines; Opioid-Related Disorders; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Urea

2016
Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats.
    Neuropeptides, 2015, Volume: 50

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Capsaicin; Dental Pulp; Hippocampus; Ibuprofen; Incisor; Learning Disabilities; Male; Maze Learning; Memory Disorders; Naphthyridines; Nerve Tissue Proteins; Nociception; Orexin Receptors; Orexins; Pain Measurement; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Single-Blind Method; Toothache; Urea

2015
Orexin receptor 1 signaling contributes to ethanol binge-like drinking: Pharmacological and molecular evidence.
    Behavioural brain research, 2015, Volume: 287

    Topics: Animals; Benzoxazoles; Binge Drinking; Blood Alcohol Content; Central Nervous System Depressants; Drinking Water; Eating; Ethanol; Hypnotics and Sedatives; Hypothalamic Area, Lateral; Locomotion; Male; Mice, Inbred C57BL; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Reflex; RNA, Messenger; Saccharin; Urea

2015
Functional inactivation of hypocretin 1 receptors in the medial prefrontal cortex affects the pyramidal neuron activity and gamma oscillations: An in vivo multiple-channel single-unit recording study.
    Neuroscience, 2015, Jun-25, Volume: 297

    Topics: Acetylcholine; Action Potentials; Animals; Benzoxazoles; Chi-Square Distribution; Cholinergic Agonists; Gamma Rhythm; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Urea

2015
Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats.
    Addiction biology, 2016, Volume: 21, Issue:3

    Topics: Animals; Behavior, Animal; Benzoxazoles; Central Nervous System Depressants; Conditioning, Psychological; Cues; Drug-Seeking Behavior; Ethanol; Extinction, Psychological; Limbic Lobe; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Inbred Strains; Signal Transduction; Urea; Ventral Tegmental Area

2016
Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Benzoxazoles; Computer Simulation; Dose-Response Relationship, Drug; Hyperthermia, Induced; Male; Methamphetamine; Models, Neurological; Monte Carlo Method; Naphthyridines; Neural Pathways; Orexin Receptors; Rats, Sprague-Dawley; Stress, Physiological; Synaptic Transmission; Temperature; Urea

2015
Orexins/hypocretins modulate the activity of NPY-positive and -negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors.
    Neuroscience, 2015, Aug-06, Volume: 300

    Topics: Animals; Benzoxazoles; Immunohistochemistry; Isoquinolines; Male; Membrane Potentials; Naphthyridines; Neurons; Neuropeptide Y; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Patch-Clamp Techniques; Presynaptic Terminals; Pyridines; Rats, Wistar; Thalamus; Tissue Culture Techniques; Urea

2015
Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep.
    Behavioural brain research, 2015, Sep-15, Volume: 291

    Topics: Animals; Appetitive Behavior; Benzoxazoles; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Hypnotics and Sedatives; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Sleep; Urea

2015
Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2-Oxazolidinones, and Benzoxazolones.
    ChemSusChem, 2015, Jul-08, Volume: 8, Issue:13

    Topics: Amines; Amino Alcohols; Aminophenols; Benzoxazoles; Catalysis; Imidazoles; Ionic Liquids; Oxamic Acid; Oxazolidinones; Oxidation-Reduction; Palladium; Urea

2015
Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats.
    Neuroscience letters, 2015, Sep-14, Volume: 604

    Topics: Animals; Benzoxazoles; Eating; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Preoptic Area; Rats, Wistar; Urea

2015
Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors.
    Brain research, 2015, Oct-22, Volume: 1624

    Topics: Analgesics; Analysis of Variance; Animals; Benzoxazoles; Carrier Proteins; Dose-Response Relationship, Drug; Formaldehyde; Locus Coeruleus; Male; Microinjections; Naphthyridines; Orexins; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Urea

2015
Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats.
    Neuropharmacology, 2015, Volume: 99

    Topics: Action Potentials; Animals; Benzoxazoles; Blood Pressure; Central Nervous System Agents; Disease Models, Animal; Male; Naphthyridines; Neuroanatomical Tract-Tracing Techniques; Neurons; Obesity; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Rats, Zucker; Spinal Cord; Sympathetic Nervous System; Tissue Culture Techniques; Up-Regulation; Urea

2015
[Effect of orexin-A and orexin-1 receptor antagonist injected into the fourth ventricle of rats on food-intake and spontaneous physical activity].
    Sheng li xue bao : [Acta physiologica Sinica], 2015, Aug-25, Volume: 67, Issue:4

    Topics: Animals; Benzoxazoles; Diet, High-Fat; Eating; Fourth Ventricle; Motor Activity; Naphthyridines; Obesity; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; Urea

2015
Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain.
    Western journal of nursing research, 2016, Volume: 38, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Benzoxazoles; Carbachol; Female; Hyperalgesia; Hypothalamic Area, Lateral; Naphthyridines; Neuralgia; Orexins; Pain Management; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Urea

2016
Orexin signaling is necessary for hypoglycemia-induced prevention of conditioned place preference.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2016, Jan-01, Volume: 310, Issue:1

    Topics: Animals; Arousal; Behavior, Animal; Benzoxazoles; Blood Glucose; Brain; Conditioning, Psychological; Disease Models, Animal; Feeding Behavior; Hypoglycemia; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats, Sprague-Dawley; Reward; Sertraline; Signal Transduction; Time Factors; Urea

2016
Orexin/Hypocretin-1 Receptor Antagonism Selectively Reduces Cue-Induced Feeding in Sated Rats and Recruits Medial Prefrontal Cortex and Thalamus.
    Scientific reports, 2015, Nov-05, Volume: 5

    Topics: Amygdala; Animals; Benzoxazoles; Cues; Eating; Feeding Behavior; Learning; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Prefrontal Cortex; Rats; Reward; Thalamus; Urea

2015
Localization, expression and role of Orexin A and its receptor in testes of neonatal mice.
    General and comparative endocrinology, 2016, 12-01, Volume: 239

    Topics: Animals; Animals, Newborn; Anti-Mullerian Hormone; Benzoxazoles; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Mice; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Testis; Tissue Distribution; Urea

2016
Role of dorsal hippocampal orexin-1 receptors in memory restoration induced by morphine sensitization phenomenon.
    Neuroscience, 2016, Jan-15, Volume: 312

    Topics: Amnesia; Animals; Behavior, Animal; Benzoxazoles; CA1 Region, Hippocampal; Central Nervous System Sensitization; Male; Maze Learning; Morphine; Naphthyridines; Narcotics; Orexin Receptors; Rats; Rats, Wistar; Receptors, Neuropeptide; Spatial Memory; Urea

2016
Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil.
    Addiction biology, 2017, Volume: 22, Issue:2

    Topics: Analgesics, Opioid; Animals; Bacterial Outer Membrane Proteins; Behavior, Animal; Benzoxazoles; Conditioning, Operant; Economics, Behavioral; Escherichia coli Proteins; Individuality; Lipoproteins; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Self Administration; Urea

2017
Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia: Involvement of Orexin Type 2 (OX2-R) Receptors.
    Endocrinology, 2016, Volume: 157, Issue:2

    Topics: Adrenal Glands; Animals; Benzoxazoles; Brain; Epinephrine; Fornix, Brain; Hypoglycemia; Hypoglycemic Agents; Hypothalamus; Insulin; Isoquinolines; Medulla Oblongata; Naphthyridines; Neural Pathways; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Urea

2016
Differential roles of orexin receptors within the dentate gyrus in stress- and drug priming-induced reinstatement of conditioned place preference in rats.
    Behavioral neuroscience, 2016, Volume: 130, Issue:1

    Topics: Analgesics, Opioid; Animals; Benzoxazoles; Conditioning, Operant; Conditioning, Psychological; Dentate Gyrus; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Isoquinolines; Male; Morphine; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Reward; Stress, Psychological; Swimming; Time Factors; Urea

2016
The role of trigeminal nucleus caudalis orexin 1 receptors in orofacial pain transmission and in orofacial pain-induced learning and memory impairment in rats.
    Physiology & behavior, 2016, Apr-01, Volume: 157

    Topics: Animals; Benzoxazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Learning Disabilities; Male; Maze Learning; Memory Disorders; Motor Activity; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Sensory System Agents; Spatial Learning; Trigeminal Nuclei; Urea

2016
Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response.
    Pflugers Archiv : European journal of physiology, 2016, Volume: 468, Issue:5

    Topics: Animals; Benzoxazoles; Carbon Dioxide; Hypercapnia; Locus Coeruleus; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pulmonary Ventilation; Rats; Rats, Wistar; Reflex; Sleep; Urea; Wakefulness

2016
Role of orexin-A in experimental autoimmune encephalomyelitis.
    Journal of neuroimmunology, 2016, Feb-15, Volume: 291

    Topics: Animals; Attention; Avoidance Learning; Benzoxazoles; Body Weight; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Exploratory Behavior; Female; Matrix Metalloproteinase 9; Maze Learning; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin-Oligodendrocyte Glycoprotein; Naphthyridines; Nitric Oxide Synthase Type II; Orexin Receptor Antagonists; Orexins; Peptide Fragments; Severity of Illness Index; Spinal Cord; Time Factors; Urea

2016
Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain.
    European journal of pain (London, England), 2016, Volume: 20, Issue:7

    Topics: Animals; Benzoxazoles; Carbachol; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; Nociception; Orexin Receptor Antagonists; Orexin Receptors; Pain; Pain Measurement; Pyridines; Rats; Rats, Wistar; Urea; Ventral Tegmental Area

2016
The blockade of GABAA receptors attenuates the inhibitory effect of orexin type 1 receptors antagonist on morphine withdrawal syndrome in rats.
    Neuroscience letters, 2016, Mar-23, Volume: 617

    Topics: Animals; Benzoxazoles; Bicuculline; GABA-A Receptor Antagonists; Locus Coeruleus; Male; Microinjections; Morphine; Naloxone; Naphthyridines; Narcotic Antagonists; Orexin Receptor Antagonists; Orexin Receptors; Rats, Wistar; Substance Withdrawal Syndrome; Urea

2016
Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats.
    Journal of pharmacological sciences, 2016, Volume: 130, Issue:2

    Topics: Analgesics; Animals; Benzoxazoles; Brain; Consciousness; Injections, Intraventricular; Injections, Subcutaneous; Levodopa; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pain Threshold; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sulpiride; Urea; Visceral Pain

2016
Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.
    Neuropharmacology, 2016, Volume: 105

    Topics: Analgesics, Opioid; Animals; Benzoxazines; Benzoxazoles; Corticosterone; Hypothalamus; Isoquinolines; Male; Mice, Inbred C57BL; Morpholines; Naloxone; Naphthalenes; Naphthyridines; Neurons; Nociceptive Pain; Orexin Receptors; Pain Perception; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Pyridines; Receptor, Cannabinoid, CB1; Signal Transduction; Stress, Psychological; Urea

2016
SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice.
    Life sciences, 2016, Apr-01, Volume: 150

    Topics: Animals; Anticonvulsants; Benzoxazoles; Brain Chemistry; Convulsants; Electroshock; Male; Mice; Muscle Strength; Myoclonus; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Psychomotor Performance; Seizures; Urea

2016
Lateral hypothalamic area orexin-A influence the firing activity of gastric distension-sensitive neurons and gastric motility in rats.
    Neuropeptides, 2016, Volume: 57

    Topics: Action Potentials; Animals; Benzoxazoles; Electric Stimulation; Gastrointestinal Motility; Hypothalamic Area, Lateral; Male; Naphthyridines; Neurons; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Urea

2016
Orexin-A facilitates emergence of the rat from isoflurane anesthesia via mediation of the basal forebrain.
    Neuropeptides, 2016, Volume: 58

    Topics: Anesthetics, Inhalation; Animals; Basal Forebrain; Benzoxazoles; Isoflurane; Male; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Urea

2016
Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction.
    Physiology & behavior, 2016, Aug-01, Volume: 162

    Topics: Analysis of Variance; Animals; Association Learning; Benzoxazoles; Conditioning, Classical; Cues; Extinction, Psychological; Food; Locomotion; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; Rats, Long-Evans; Signal Transduction; Urea

2016
Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats.
    Brain research, 2016, 05-15, Volume: 1639

    Topics: Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Conditioning, Psychological; Dentate Gyrus; Dose-Response Relationship, Drug; Extinction, Psychological; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Random Allocation; Rats, Wistar; Spatial Behavior; Urea

2016
Hypocretinergic system in the medial preoptic area promotes maternal behavior in lactating rats.
    Peptides, 2016, Volume: 81

    Topics: Animals; Behavior Rating Scale; Benzoxazoles; Female; Hypothalamic Area, Lateral; Hypothalamus, Posterior; Infusions, Intraventricular; Lactation; Maternal Behavior; Microinjections; Naphthyridines; Neurons; Orexin Receptors; Orexins; Preoptic Area; Rats; Rats, Wistar; Statistics, Nonparametric; Urea

2016
The role of orexin type-1 receptors in the development of morphine tolerance in locus coeruleus neurons: An electrophysiological perspective.
    Brain research, 2016, 09-01, Volume: 1646

    Topics: Action Potentials; Animals; Benzoxazoles; Drug Tolerance; Locus Coeruleus; Male; Morphine; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Urea

2016
Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats.
    European journal of pain (London, England), 2016, Volume: 20, Issue:10

    Topics: Animals; Benzoxazoles; Carbachol; Disease Models, Animal; Hypothalamic Area, Lateral; Male; Microinjections; Naphthyridines; Orexin Receptors; Orexins; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Stimulation, Chemical; Urea

2016
Orexin-A increases the activity of globus pallidus neurons in both normal and parkinsonian rats.
    The European journal of neuroscience, 2016, Volume: 44, Issue:5

    Topics: Action Potentials; Animals; Benzoxazoles; Globus Pallidus; Haloperidol; Male; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Oxidopamine; Parkinson Disease; Postural Balance; Rats; Rats, Wistar; Urea

2016
Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice.
    Neuropharmacology, 2016, Volume: 110, Issue:Pt A

    Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Animals; Benzoxazoles; Choice Behavior; Compulsive Behavior; Dose-Response Relationship, Drug; Isoquinolines; Male; Mice, Inbred C57BL; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Quinine; Urea

2016
Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 359, Issue:2

    Topics: Animals; Benzoxazoles; Cocaine; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Isoquinolines; Male; Naphthyridines; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Wistar; Urea

2016
The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat.
    Neuroreport, 2016, Oct-19, Volume: 27, Issue:15

    Topics: Animals; Anxiety; Benzoxazoles; Capsaicin; Disease Models, Animal; Exploratory Behavior; Facial Pain; Formaldehyde; Male; Maze Learning; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pain Measurement; Rats; Rats, Wistar; Time Factors; Trigeminal Nuclei; Urea

2016
Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats.
    Biological psychiatry, 2017, 04-01, Volume: 81, Issue:7

    Topics: Animals; Benzoxazoles; Central Amygdaloid Nucleus; Cocaine; Drug-Seeking Behavior; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Stress, Psychological; Urea

2017
Role of the orexin (hypocretin) system in contextual fear conditioning in rats.
    Behavioural brain research, 2017, 01-01, Volume: 316

    Topics: Animals; Benzoxazoles; Conditioning, Classical; Electroshock; Fear; Gene Expression Regulation; Hypothalamus; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Urea

2017
Blockade of orexin receptors attenuates the cardiovascular response to air-jet stress in spontaneously hypertensive rats.
    Autonomic neuroscience : basic & clinical, 2016, Volume: 201

    Topics: Acetamides; Air; Animals; Benzoxazoles; Blood Pressure; Brain; Brain-Derived Neurotrophic Factor; Cardiovascular Agents; Dose-Response Relationship, Drug; Heart Rate; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Physical Stimulation; Random Allocation; Rats, Inbred SHR; Rats, Wistar; RNA, Messenger; Species Specificity; Stress, Psychological; Urea

2016
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.
    Fundamental & clinical pharmacology, 2017, Volume: 31, Issue:2

    Topics: Animals; Anxiety; Benzoxazoles; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Maze Learning; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Urea

2017
Blockade of dorsal hippocampal orexin-1 receptors impaired morphine-induced state-dependent learning.
    Neuropeptides, 2016, Volume: 60

    Topics: Animals; Avoidance Learning; Benzoxazoles; Hippocampus; Male; Memory; Mice; Morphine; Motor Activity; Naphthyridines; Narcotics; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Urea

2016
Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.
    Brain research, 2017, Jan-01, Volume: 1654, Issue:Pt A

    Topics: Alcohol Drinking; Alcohol-Related Disorders; Animals; Animals, Outbred Strains; Benzoxazoles; Central Nervous System Depressants; Conditioning, Operant; Cues; Disease Models, Animal; Drug-Seeking Behavior; Ethanol; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats, Sprague-Dawley; Self Administration; Urea

2017
Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats.
    Neuroscience letters, 2017, 01-01, Volume: 636

    Topics: Animals; Benzoxazoles; Disease Models, Animal; Glutamic Acid; Locus Coeruleus; Male; Microinjections; Morphine; Naphthyridines; Orexin Receptor Antagonists; Orexins; Rats, Wistar; Substance Withdrawal Syndrome; Urea

2017
Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.
    Organic & biomolecular chemistry, 2016, Dec-28, Volume: 14, Issue:48

    Topics: Amides; Benzoxazoles; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Molecular Structure; Organoselenium Compounds; Oxidation-Reduction; Structure-Activity Relationship; Urea

2016
The Role of Orexin Signaling in the Ventral Tegmental Area and Central Amygdala in Modulating Binge-Like Ethanol Drinking Behavior.
    Alcoholism, clinical and experimental research, 2017, Volume: 41, Issue:3

    Topics: Animals; Benzoxazoles; Binge Drinking; Central Amygdaloid Nucleus; Ethanol; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Signal Transduction; Urea; Ventral Tegmental Area

2017
NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway.
    Biochemical and biophysical research communications, 2017, 04-01, Volume: 485, Issue:2

    Topics: Animals; Atropine; Benzoxazoles; Gastric Acid; Gastric Emptying; Injections, Intraventricular; Male; Naphthyridines; Nerve Tissue Proteins; Orexin Receptors; Parasympatholytics; Rats, Sprague-Dawley; Rats, Transgenic; Rats, Wistar; Signal Transduction; Urea; Vagus Nerve

2017
The effect of orexin 1 and orexin 2 receptors antagonisms in the basolateral amygdala on memory processing in a passive avoidance task.
    Physiology & behavior, 2017, 05-15, Volume: 174

    Topics: Animals; Avoidance Learning; Basolateral Nuclear Complex; Benzoxazoles; Dose-Response Relationship, Drug; Isoquinolines; Male; Memory; Mental Recall; Naphthyridines; Orexin Receptor Antagonists; Pyridines; Rats; Rats, Wistar; Reaction Time; Urea

2017
Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X
    Bioorganic & medicinal chemistry letters, 2017, 06-01, Volume: 27, Issue:11

    Topics: Adamantane; Adenosine Triphosphate; Benzoxazoles; Cell Line; Fluorescent Dyes; Guanidines; Humans; Molecular Structure; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Quinolinium Compounds; Thiourea; Urea

2017
Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is Associated with the Activation of Specific Amygdala Cell Subpopulations.
    The international journal of neuropsychopharmacology, 2017, 08-01, Volume: 20, Issue:8

    Topics: Animals; Basolateral Nuclear Complex; Benzoxazoles; Calbindins; Extinction, Psychological; Fear; Male; Memory Consolidation; Mice, Inbred C57BL; Naphthyridines; Neural Pathways; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Parvalbumins; Prefrontal Cortex; Psychotropic Drugs; Urea

2017
Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus.
    Pharmacology, biochemistry, and behavior, 2017, Volume: 158

    Topics: Animals; Benzoxazoles; Hippocampus; Male; Microinjections; Morphine; Naloxone; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Urea

2017
Effects of Suvorexant, a Dual Orexin/Hypocretin Receptor Antagonist, on Impulsive Behavior Associated with Cocaine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:5

    Topics: Animals; Azepines; Benzoxazoles; Choice Behavior; Cocaine; Delay Discounting; Impulsive Behavior; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexins; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Triazoles; Urea; Ventral Tegmental Area

2018
Role of orexin receptors in the ventral tegmental area on acquisition and expression of morphine-induced conditioned place preference in the rats.
    Neuropeptides, 2017, Volume: 66

    Topics: Animals; Benzoxazoles; Conditioning, Operant; Isoquinolines; Male; Morphine; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Reward; Urea; Ventral Tegmental Area

2017
Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors.
    Investigative ophthalmology & visual science, 2017, 09-01, Volume: 58, Issue:11

    Topics: Amacrine Cells; Animals; Benzoxazoles; Dopamine; Female; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naphthyridines; Orexin Receptor Antagonists; Orexins; Patch-Clamp Techniques; Photoreceptor Cells, Vertebrate; Pyridines; Retinal Ganglion Cells; Rod Opsins; Signal Transduction; Urea

2017
Blockade of the orexin receptors in the CA1 region of hippocampus decreased the lateral hypothalamic-induced antinociceptive responses in the model of orofacial formalin test in the rats.
    Peptides, 2018, Volume: 99

    Topics: Analgesics; Animals; Benzoxazoles; CA1 Region, Hippocampal; Facial Pain; Formaldehyde; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Urea

2018
The Subthalamic Neurons are Activated by Both Orexin-A and Orexin-B.
    Neuroscience, 2018, 01-15, Volume: 369

    Topics: Action Potentials; Animals; Benzoxazoles; Isoquinolines; Male; Motor Activity; Naphthyridines; Neurons; Neurotransmitter Agents; Orexin Receptors; Orexins; Pyridines; Rats, Wistar; Subthalamic Nucleus; Urea

2018
Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats.
    Brain research bulletin, 2018, Volume: 137

    Topics: Animals; Benzoxazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Food Deprivation; Isoquinolines; Male; Morphine; Morphine Dependence; Naphthyridines; Narcotics; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats, Wistar; Urea

2018
Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats.
    Peptides, 2018, Volume: 101

    Topics: Animals; Behavior, Animal; Benzoxazoles; CA1 Region, Hippocampal; Gene Expression Regulation; Male; Morphine; Naphthyridines; Orexin Receptors; Rats; Rats, Wistar; Urea

2018
Role of dorsal hippocampal orexin-1 receptors in modulation of antinociception induced by chemical stimulation of the lateral hypothalamus.
    Physiology & behavior, 2018, 03-01, Volume: 185

    Topics: Analgesics; Animals; Benzoxazoles; CA1 Region, Hippocampal; Carbachol; Catheters, Indwelling; Cholinergic Agonists; Dose-Response Relationship, Drug; Formaldehyde; Hypothalamic Area, Lateral; Inflammation; Male; Naphthyridines; Nociceptive Pain; Orexin Receptor Antagonists; Orexin Receptors; Pain Perception; Rats, Wistar; Stimulation, Chemical; Urea

2018
Orexin 1 and orexin 2 receptor antagonism in the basolateral amygdala modulate long-term potentiation of the population spike in the perforant path-dentate gyrus-evoked field potential in rats.
    Neurobiology of learning and memory, 2018, Volume: 149

    Topics: Action Potentials; Animals; Basolateral Nuclear Complex; Benzoxazoles; Dentate Gyrus; Electric Stimulation; Isoquinolines; Long-Term Potentiation; Naphthyridines; Neural Pathways; Neurons; Orexin Receptor Antagonists; Perforant Pathway; Pyridines; Rats; Urea

2018
Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats.
    Brain research, 2018, 05-01, Volume: 1686

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzoxazoles; Brain; Consciousness; Dopamine; Ghrelin; Male; Naphthyridines; Orexins; Rats, Sprague-Dawley; Receptors, Dopamine D1; Urea; Visceral Pain

2018
SB-334867 (an Orexin-1 Receptor Antagonist) Effects on Morphine-Induced Sensitization in Mice-a View on Receptor Mechanisms.
    Molecular neurobiology, 2018, Volume: 55, Issue:11

    Topics: Animals; Astrocytes; Benzoxazoles; Brain; Male; Mice; Microglia; Morphine; Motor Activity; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger; Urea

2018
Sex- and Age-dependent Effects of Orexin 1 Receptor Blockade on Open-Field Behavior and Neuronal Activity.
    Neuroscience, 2018, 06-15, Volume: 381

    Topics: Age Factors; Animals; Benzoxazoles; Brain; Exploratory Behavior; Female; Male; Naphthyridines; Neurons; Orexin Receptors; Rats; Rats, Sprague-Dawley; Sex Characteristics; Urea

2018
Modulation by orexin A of spontaneous excitatory and inhibitory transmission in adult rat spinal substantia gelatinosa neurons.
    Biochemical and biophysical research communications, 2018, 06-18, Volume: 501, Issue:1

    Topics: Animals; Benzoxazoles; Dioxanes; Excitatory Postsynaptic Potentials; GABAergic Neurons; Glycine; Inhibitory Postsynaptic Potentials; Male; Naphthyridines; Neurons; Orexin Receptors; Orexins; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Substantia Gelatinosa; Synaptic Transmission; Urea

2018
Effects of intrathecal administration of orexin-1 receptor antagonist on antinociceptive responses induced by chemical stimulation of lateral hypothalamus in an animal model of tonic nociception.
    Neuropeptides, 2018, Volume: 69

    Topics: Analgesics; Animals; Benzoxazoles; Hypothalamic Area, Lateral; Injections, Spinal; Male; Naphthyridines; Nociception; Orexin Receptor Antagonists; Orexin Receptors; Pain; Pain Measurement; Rats, Wistar; Spinal Cord; Urea

2018
Hypocretin/orexin antagonists decrease cocaine self-administration by female rhesus monkeys.
    Drug and alcohol dependence, 2018, 07-01, Volume: 188

    Topics: Animals; Behavior, Addictive; Benzoxazoles; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Naphthyridines; Orexins; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Urea

2018
Orexin-1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory.
    International endodontic journal, 2018, Volume: 51, Issue:12

    Topics: Animal Experimentation; Animals; Benzoxazoles; Capsaicin; Dental Pulp; Dose-Response Relationship, Drug; Male; Medulla Oblongata; Naphthyridines; Nociception; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; Rats, Wistar; Sensory System Agents; Spatial Learning; Spatial Memory; Urea

2018
Orexin A presynaptically decreases inhibitory synaptic transmission in rat locus coeruleus neurons.
    Neuroscience letters, 2018, 09-14, Volume: 683

    Topics: Animals; Benzoxazoles; Dose-Response Relationship, Drug; Inhibitory Postsynaptic Potentials; Locus Coeruleus; Male; Naphthyridines; Neural Inhibition; Neurons; Orexins; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Synaptic Transmission; Urea

2018
Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas.
    Behavioural brain research, 2018, 11-01, Volume: 353

    Topics: Animals; Benzoxazoles; Brain; Male; Maze Learning; Memory Consolidation; Memory Disorders; Naphthyridines; Orexin Receptors; Practice, Psychological; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Rats, Wistar; Reversal Learning; Spatial Memory; Urea

2018
Role of orexin-1 and orexin-2 receptors in the CA1 region of hippocampus in the forced swim stress- and food deprivation-induced reinstatement of morphine seeking behaviors in rats.
    Brain research bulletin, 2018, Volume: 142

    Topics: Animals; Benzoxazoles; CA1 Region, Hippocampal; Drug-Seeking Behavior; Extinction, Psychological; Food Deprivation; Isoquinolines; Male; Morphine Dependence; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats, Wistar; Stress, Psychological; Swimming; Urea

2018
The hypothalamic neuropeptide orexin A- a possible regulator in glucose homeostasis and germ cell kinetics in adult mice testes.
    Biochimie, 2018, Volume: 152

    Topics: Animals; Benzoxazoles; Blotting, Western; Cell Cycle; Cell Proliferation; Cell Survival; Flow Cytometry; Glucose; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 3; Homeostasis; Hypothalamus; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Male; Mice; Naphthyridines; Orexin Receptors; Orexins; Spermatozoa; Urea

2018
Orexins Facilitates Osteogenic Differentiation of MC3T3-E1 Cells.
    IUBMB life, 2018, Volume: 70, Issue:7

    Topics: Alkaline Phosphatase; Animals; Benzoxazoles; Calcification, Physiologic; Carbazoles; Cell Differentiation; Cell Line; Core Binding Factor Alpha 2 Subunit; Culture Media; Dose-Response Relationship, Drug; Mice; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Urea

2018
Activation of orexin-1 receptors in the ventrolateral periaqueductal grey matter (vlPAG) modulates pulpal nociception and the induction of substance P in vlPAG and trigeminal nucleus caudalis.
    International endodontic journal, 2019, Volume: 52, Issue:3

    Topics: Animals; Benzoxazoles; Bicuculline; Capsaicin; Dental Pulp; Fluorescent Antibody Technique; Male; Naphthyridines; Nociception; Orexins; Periaqueductal Gray; Rats; Rats, Wistar; Substance P; Trigeminal Nuclei; Urea

2019
Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats.
    Neuromolecular medicine, 2018, Volume: 20, Issue:4

    Topics: Animals; Benzoxazoles; Dioxanes; Dynorphins; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Hypothalamus; Injections, Intraventricular; Kisspeptins; Luteinizing Hormone; Male; Naphthyridines; Neurokinin B; Neurons; Orexins; Phenylurea Compounds; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reproduction; Sexual Behavior, Animal; Testosterone; Urea

2018
Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats.
    Biological psychiatry, 2019, 06-01, Volume: 85, Issue:11

    Topics: Animals; Benzoxazoles; Cell Count; Cocaine; Drug-Seeking Behavior; Extinction, Psychological; Gene Knockdown Techniques; Hypothalamic Area, Lateral; Hypothalamic Hormones; Male; Melanins; Microinjections; Morpholinos; Motivation; Naphthyridines; Neurons; Orexins; Pituitary Hormones; Rats; Self Administration; Urea

2019
Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 03-08, Volume: 89

    Topics: Animals; Benzoxazoles; Cost-Benefit Analysis; Decision Making; Gyrus Cinguli; Male; Motor Activity; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Prefrontal Cortex; Psychotropic Drugs; Rats, Wistar; Reward; Urea

2019
Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin-1 receptor antagonist in rats.
    The European journal of neuroscience, 2019, Volume: 50, Issue:3

    Topics: Animals; Behavior, Addictive; Benzoxazoles; Cocaine; Dose-Response Relationship, Drug; Endophenotypes; Forecasting; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Sprague-Dawley; Self Administration; Treatment Outcome; Urea

2019
Orexin-A signaling in the paraventricular nucleus modulates spontaneous firing of glucose-sensitive neurons and promotes food intake via the NPY pathway in rats.
    Biochemical and biophysical research communications, 2018, 10-20, Volume: 505, Issue:1

    Topics: Animals; Benzoxazoles; Dihydropyridines; Eating; Glucose; Male; Naphthyridines; Neurons; Neuropeptide Y; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Phenylurea Compounds; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Signal Transduction; Urea

2018
The basolateral amygdala orexin 1 and 2 receptors' involvement in modulating spatial reference memory.
    Brain research, 2019, 02-01, Volume: 1704

    Topics: Animals; Basolateral Nuclear Complex; Benzoxazoles; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Spatial Memory; Urea

2019
The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain.
    Arquivos de neuro-psiquiatria, 2018, Volume: 76, Issue:9

    Topics: Animals; Benzoxazoles; Brain-Derived Neurotrophic Factor; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Facial Pain; Hippocampus; Male; Naphthyridines; Neurons; Orexin Receptors; Orexins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Urea

2018
Co-administration of the low dose of orexin and nitrergic antagonists induces an antidepressant-like effect in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: Animals; Antidepressive Agents; Benzoxazoles; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hindlimb Suspension; Locomotion; Male; Mice; Naphthyridines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Orexins; Swimming; Treatment Outcome; Urea

2019
Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits.
    Neurobiology of learning and memory, 2019, Volume: 157

    Topics: Animals; Anxiety; Benzoxazoles; Hippocampus; Isoquinolines; Male; Maze Learning; Memory; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats, Wistar; Social Behavior; Stress, Psychological; Urea

2019
Orexin facilitates GABAergic IPSCs via postsynaptic OX
    Neuropharmacology, 2019, 05-01, Volume: 149

    Topics: Animals; Animals, Genetically Modified; Benzoxazoles; Cerebral Cortex; GABAergic Neurons; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoquinolines; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Patch-Clamp Techniques; Protein Kinase C; Pyramidal Cells; Pyridines; Rats; Urea

2019
The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats.
    Journal of neuroscience research, 2020, Volume: 98, Issue:1

    Topics: Animals; Arousal; Benzoxazoles; Dioxanes; Ethanol; Hyperbaric Oxygenation; Ketamine; Male; Naphthyridines; Orexin Receptor Antagonists; Orexins; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Reflex, Righting; Unconsciousness; Up-Regulation; Urea

2020
The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task.
    Brain research, 2020, 03-15, Volume: 1731

    Topics: Animals; Benzoxazoles; Drug-Seeking Behavior; Executive Function; Inhibition, Psychological; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats, Sprague-Dawley; Reward; Urea

2020
Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice.
    Biochemical and biophysical research communications, 2019, 06-18, Volume: 514, Issue:1

    Topics: Animals; Benzoxazoles; Exercise Test; Hypothalamus; Leptin; Male; Mice, Inbred C57BL; Naphthyridines; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Phosphorylation; Physical Conditioning, Animal; Receptors, Leptin; STAT3 Transcription Factor; Urea

2019
The role of orexin-1 receptor signaling in demand for the opioid fentanyl.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, Volume: 44, Issue:10

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzoxazoles; Conditioning, Operant; Cues; Drug-Seeking Behavior; Economics, Behavioral; Extinction, Psychological; Fentanyl; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Sprague-Dawley; Self Administration; Urea

2019
Role of orexin receptors within the dentate gyrus of the hippocampus in antinociception induced by chemical stimulation of the lateral hypothalamus in the tail-flick test as a model of acute pain in rats.
    Physiology & behavior, 2019, 10-01, Volume: 209

    Topics: Acute Pain; Analgesics; Animals; Benzoxazoles; Carbachol; Dentate Gyrus; Dose-Response Relationship, Drug; Isoquinolines; Male; Motor Activity; Naphthyridines; Nociception; Orexin Receptor Antagonists; Orexin Receptors; Pain Measurement; Pyridines; Rats; Rats, Wistar; Stimulation, Chemical; Urea

2019
Role of orexin-1 and -2 receptors within the nucleus accumbens in the acquisition of sensitization to morphine in rats.
    Behavioural brain research, 2019, 11-05, Volume: 373

    Topics: Animals; Benzoxazoles; Conditioning, Classical; Conditioning, Operant; Conditioning, Psychological; Drug Interactions; Drug Tolerance; Isoquinolines; Male; Morphine; Morphine Dependence; Naphthyridines; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pyridines; Rats; Rats, Wistar; Reward; Urea

2019
Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil.
    Brain research, 2020, 03-15, Volume: 1731

    Topics: Analgesics, Opioid; Animals; Basal Forebrain; Benzoxazoles; Conditioning, Operant; Drug-Seeking Behavior; Male; Motivation; Naphthyridines; Rats, Sprague-Dawley; Remifentanil; Reward; Urea

2020
Orexin-1 Receptor Signaling in Ventral Pallidum Regulates Motivation for the Opioid Remifentanil.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019, 12-04, Volume: 39, Issue:49

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzoxazoles; Cues; Drug-Seeking Behavior; Economics, Behavioral; Globus Pallidus; Male; Motivation; Motor Activity; Naphthyridines; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Recurrence; Remifentanil; Reward; Urea

2019
Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats.
    Pharmacological reports : PR, 2019, Volume: 71, Issue:6

    Topics: Aminopyridines; Animals; Benzoxazoles; Locomotion; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Sulfonamides; Urea

2019
Brain orexin improves intestinal barrier function via the vagal cholinergic pathway.
    Neuroscience letters, 2020, 01-01, Volume: 714

    Topics: Animals; Antimetabolites; Atropine; Benzoxazoles; Colon; Deoxyglucose; Efferent Pathways; Intestinal Mucosa; Lipopolysaccharides; Muscarinic Antagonists; Naphthyridines; Orexin Receptor Antagonists; Orexins; Permeability; Rats; Subarachnoid Space; Urea; Vagotomy; Vagus Nerve

2020
Role of orexinergic receptors in the dentate gyrus of the hippocampus in the acquisition and expression of morphine-induced conditioned place preference in rats.
    Behavioural brain research, 2020, 02-03, Volume: 379

    Topics: Animals; Behavior, Animal; Benzoxazoles; Conditioning, Classical; Dentate Gyrus; Isoquinolines; Male; Morphine; Naphthyridines; Narcotics; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Reward; Urea

2020
The role of the nucleus accumbens OXR1 in cocaine-induced locomotor sensitization.
    Behavioural brain research, 2020, 02-03, Volume: 379

    Topics: Animals; Behavior, Animal; Benzoxazoles; Central Nervous System Sensitization; Cocaine; Dopamine Uptake Inhibitors; Locomotion; Male; Mitochondrial Proteins; Naphthyridines; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Urea

2020
Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats.
    Neuropharmacology, 2020, 03-01, Volume: 164

    Topics: Analgesics, Opioid; Animals; Benzoxazoles; Drug-Seeking Behavior; Isoquinolines; Male; Naphthyridines; Opioid-Related Disorders; Orexin Receptors; Orexins; Oxycodone; Prescription Drug Misuse; Pyridines; Rats; Rats, Wistar; Self Administration; Urea

2020
The contribution of orexin receptors within the ventral tegmental area to modulation of antinociception induced by chemical stimulation of the lateral hypothalamus in the animal model of orofacial pain in the rats.
    Behavioural pharmacology, 2020, Volume: 31, Issue:5

    Topics: Animals; Benzoxazoles; Carbachol; Dose-Response Relationship, Drug; Facial Pain; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pain Measurement; Pyridines; Rats; Urea; Ventral Tegmental Area

2020
Involvement of Orexinergic System Within the Nucleus Accumbens in Pain Modulatory Role of the Lateral Hypothalamus in Orofacial Pain Model.
    Neurochemical research, 2020, Volume: 45, Issue:4

    Topics: Analgesics, Non-Narcotic; Animals; Benzoxazoles; Carbachol; Facial Pain; Formaldehyde; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; Nociception; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats, Wistar; Urea

2020
Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord.
    Brain research, 2020, 04-01, Volume: 1732

    Topics: Animals; Benzoxazoles; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Hypothalamic Area, Lateral; Isoquinolines; Naphthyridines; Neuralgia; Orexin Receptor Antagonists; Orexin Receptors; Pain Management; Pain Threshold; Pyridines; Rats; Rats, Wistar; Spinal Cord; Urea

2020
Central neuropeptide-S administration alleviates stress-induced impairment of gastric motor functions through orexin-A.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2020, Volume: 31, Issue:1

    Topics: Animals; Benzoxazoles; Gastric Emptying; Hypothalamus; Naphthyridines; Neuropeptides; Orexins; Postprandial Period; Pyloric Antrum; Rats; Restraint, Physical; Stress, Physiological; Urea; Vagus Nerve

2020
Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD.
    Behavioural brain research, 2020, 04-20, Volume: 384

    Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Benzoxazoles; Disease Models, Animal; Elevated Plus Maze Test; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Hypothalamus; Memory; Naphthyridines; Open Field Test; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; RNA, Messenger; Stress Disorders, Post-Traumatic; Urea

2020
Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice.
    European journal of pharmacology, 2020, May-05, Volume: 874

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Benzoxazoles; Brain; Brain Ischemia; Hyperalgesia; Isoquinolines; Male; Mice; Mitochondrial Proteins; Naphthyridines; Neuralgia; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperazines; Pyridines; Serotonin Antagonists; Signal Transduction; Urea; Yohimbine

2020
Sex Differences in Demand for Highly Palatable Foods: Role of the Orexin System.
    The international journal of neuropsychopharmacology, 2021, 01-20, Volume: 24, Issue:1

    Topics: Animals; Behavior, Animal; Benzoxazoles; Eating; Economics, Behavioral; Feeding Behavior; Female; Male; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexins; Rats; Rats, Sprague-Dawley; Sex Characteristics; Urea

2021
Hindbrain orexin 1 receptors blunt intake suppression by gastrointestinal nutrients and cholecystokinin in male rats.
    Peptides, 2020, Volume: 133

    Topics: Animals; Benzoxazoles; Chocolate; Cholecystokinin; Eating; Feeding Behavior; Male; Naphthyridines; Neurons; Nutrients; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats, Wistar; Rhombencephalon; Urea

2020
Phospholipase Cβ3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze.
    Life sciences, 2020, Sep-15, Volume: 257

    Topics: Animals; Benzoxazoles; Hippocampus; Male; Maze Learning; Memory; Naphthyridines; Orexin Receptors; Orexins; Phospholipase C beta; Rats; Rats, Wistar; Urea

2020
Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats.
    Neurochemical research, 2020, Volume: 45, Issue:9

    Topics: Animals; Benzoxazoles; Central Nervous System Stimulants; Conditioning, Classical; Drug-Seeking Behavior; Isoquinolines; Male; Methamphetamine; Naphthyridines; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats, Wistar; Urea

2020
Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats.
    Neuropharmacology, 2020, 11-01, Volume: 178

    Topics: Animals; Benzoxazoles; Calcitonin Gene-Related Peptide; Male; Microinjections; Migraine Disorders; Naphthyridines; Nitroglycerin; Orexin Receptor Antagonists; Orexin Receptors; Periaqueductal Gray; Rats; Rats, Wistar; Trigeminal Nuclei; Up-Regulation; Urea

2020
Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats.
    The International journal of neuroscience, 2022, Volume: 132, Issue:1

    Topics: Animals; Behavior, Animal; Benzoxazoles; Disease Models, Animal; Morphine; Morphine Dependence; Naloxone; Naphthyridines; Narcotic Antagonists; Narcotics; Nociceptive Pain; Orexin Receptor Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Urea

2022
Chemical stimulation of the lateral hypothalamus induced seeking behaviors in rats: Involvement of orexin receptors in the ventral tegmental area.
    European journal of pharmacology, 2020, Nov-05, Volume: 886

    Topics: Animals; Behavior, Animal; Benzoxazoles; Carbachol; Conditioning, Operant; Dose-Response Relationship, Drug; Exploratory Behavior; Extinction, Psychological; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Muscarinic Agonists; Naphthyridines; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Reward; Stimulation, Chemical; Urea; Ventral Tegmental Area

2020
Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system.
    Addiction biology, 2021, Volume: 26, Issue:3

    Topics: Animals; Benzoxazoles; Drug-Seeking Behavior; Economics, Behavioral; Fentanyl; Male; Motivation; Naphthyridines; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Self Administration; Urea

2021
The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Animals; Benzoxazoles; Choice Behavior; Conditioning, Classical; Cues; Hypothalamic Area, Lateral; Isoquinolines; Male; Midline Thalamic Nuclei; Motivation; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Sprague-Dawley; Reward; Urea

2020
The orexin receptors in the ventral tegmental area are involved in the development of sensitization to expression of morphine-induced preference in rats.
    Behavioural pharmacology, 2020, Volume: 31, Issue:8

    Topics: Animals; Benzoxazoles; Brain; Carbachol; Conditioning, Classical; Conditioning, Operant; Conditioning, Psychological; Drug-Seeking Behavior; Hypothalamic Area, Lateral; Isoquinolines; Male; Morphine; Naphthyridines; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pyridines; Rats; Rats, Wistar; Reward; Urea; Ventral Tegmental Area

2020
Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking.
    Journal of psychopharmacology (Oxford, England), 2020, Volume: 34, Issue:11

    Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Addictive; Behavior, Animal; Benzoxazoles; Conditioning, Operant; Disease Models, Animal; Lateral Thalamic Nuclei; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Punishment; Rats; Septal Nuclei; Signal Transduction; Urea

2020
The modulation of the spatial reference memory by the orexinergic system of the dorsal raphe nucleus.
    Life sciences, 2021, Jan-15, Volume: 265

    Topics: Animals; Benzoxazoles; Dorsal Raphe Nucleus; Male; Morris Water Maze Test; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Spatial Memory; Urea

2021
Blockade of orexin receptors in the ventral tegmental area reduced the extinction period of the lateral hypothalamic-induced conditioned place preference in rats.
    Behavioural pharmacology, 2021, 02-01, Volume: 32, Issue:1

    Topics: Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Conditioning, Classical; Dose-Response Relationship, Drug; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Reward; Urea; Ventral Tegmental Area

2021
Central blockade of orexin type 1 receptors reduces naloxone induced activation of locus coeruleus neurons in morphine dependent rats.
    Neuroscience letters, 2021, 06-11, Volume: 755

    Topics: Action Potentials; Analgesics, Opioid; Animals; Benzoxazoles; Injections, Intraperitoneal; Injections, Intraventricular; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naloxone; Naphthyridines; Narcotic Antagonists; Neurons; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Urea

2021
Blockade of orexin receptors in the hippocampal dentate gyrus reduced the extinction latency of morphine-induced place preference in male rats.
    Neuroscience letters, 2021, 06-21, Volume: 756

    Topics: Animals; Benzoxazoles; Conditioning, Operant; Dentate Gyrus; Drug-Seeking Behavior; Extinction, Psychological; Isoquinolines; Male; Morphine; Naphthyridines; Narcotics; Orexin Receptor Antagonists; Pyridines; Rats; Rats, Wistar; Urea

2021
Wakefulness-Promoting Effects of Lateral Hypothalamic Area-Deep Brain Stimulation in Traumatic Brain Injury-Induced Comatose Rats: Upregulation of α1-Adrenoceptor Subtypes and Downregulation of Gamma-Aminobutyric Acid β Receptor Expression Via the Orexins
    World neurosurgery, 2021, Volume: 152

    Topics: Anesthesia; Animals; Benzoxazoles; Brain Injuries, Traumatic; Coma; Consciousness; Deep Brain Stimulation; Delta Rhythm; Electroencephalography; Female; Functional Laterality; Hypothalamic Area, Lateral; Injections, Intraventricular; Male; Naphthyridines; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, GABA; Signal Transduction; Urea; Wakefulness

2021
Orexin one receptors within the basolateral amygdala are involved in the modulation of cognitive deficits associated with a migraine-like state in rats.
    Neurological research, 2021, Volume: 43, Issue:12

    Topics: Animals; Basolateral Nuclear Complex; Benzoxazoles; Cognitive Dysfunction; Male; Migraine Disorders; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Urea

2021
Role of hippocampal orexin receptors in antinociception elicited by chemical stimulation of the lateral hypothalamus in the tail-flick test.
    Behavioural brain research, 2021, 09-24, Volume: 414

    Topics: Animals; Behavior, Animal; Benzoxazoles; CA1 Region, Hippocampal; Carbachol; Dimethyl Sulfoxide; Hypothalamic Area, Lateral; Isoquinolines; Male; Muscarinic Agonists; Naphthyridines; Nociception; Orexin Receptor Antagonists; Orexin Receptors; Pyridines; Rats; Rats, Wistar; Stimulation, Chemical; Urea

2021
Similar role of mPFC orexin-1 receptors in the acquisition and expression of morphine- and food-induced conditioned place preference in male rats.
    Neuropharmacology, 2021, 10-15, Volume: 198

    Topics: Animals; Benzoxazoles; Conditioning, Operant; Drug-Seeking Behavior; Food; Male; Morphine; Morphine Dependence; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Prefrontal Cortex; Rats; Rats, Wistar; Reward; Urea

2021
The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats.
    Peptides, 2021, Volume: 146

    Topics: Animals; Anxiety; Behavior, Animal; Benzoxazoles; Male; Migraine Disorders; Naphthyridines; Orexin Receptors; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Neuropeptide; Social Behavior; Urea

2021
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
    Peptides, 2022, Volume: 147

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoxazoles; CA1 Region, Hippocampal; Cyclophosphamide; Disease Models, Animal; Doxorubicin; Etoposide; Inflammation; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pain; Pain Measurement; Prednisone; Pyridines; Rats, Wistar; Stress, Psychological; Urea; Vincristine

2022
Intracerebroventricular infusion of the selective orexin 1 receptor antagonist SB-334867 impairs cognitive flexibility in a sex-dependent manner.
    Behavioural brain research, 2022, 04-29, Volume: 424

    Topics: Animals; Benzoxazoles; Cognition; Female; Infusions, Intraventricular; Male; Mice; Mice, Inbred C57BL; Naphthyridines; Orexin Receptors; Orexins; Urea

2022
Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 219

    Topics: Animals; Antidepressive Agents; Benzoxazoles; Brain-Derived Neurotrophic Factor; Citalopram; Depression; Male; Mice; Naphthyridines; Orexins; Sleep Deprivation; Sleep, REM; Urea

2022