Compounds > benzoxazoles
Page last updated: 2024-08-21

benzoxazoles and l-697661

benzoxazoles has been researched along with l-697661 in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's21 (95.45)18.2507
2000's1 (4.55)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bamberger, DL; Fisher, TE; Goldman, ME; Hoffman, JM; Jones, JH; Rooney, CS; Saari, WS; Smith, AM; Thomas, CM; Wai, JS1
Condra, JH; Emini, EA; Gotlib, L; Graham, DJ; Lineberger, DW; Long, WJ; Sardana, VV; Schlabach, AJ; Wolfgang, JA1
Harris, PJ1
Bender, R; Kirsch, R; Kleim, JP; Meichsner, C; Paessens, A; Riess, G1
Carroll, SS; Culberson, JC; Kuo, LC; Olsen, DB; Shafer, JA1
Byrnes, VW; Condra, JH; Emini, EA; Sardana, VV; Schleif, WA1
Bäckbro, K; Noréen, R; Oberg, B; Unge, T; Vrang, L; Zhang, H1
Evans, DB; Fan, N; Rank, KB; Sharma, SK; Tarpley, WG; Thomas, RC2
Byrnes, VW; Emini, EA; Kessler, JA; Lineberger, DW; Massari, F; Staszewski, S; Waterbury, JA1
Anderson, KW; Bakshi, KK; Durr, S; Göhler, R; Kober, A; Massari, FE; Schneider, CL; Staszewski, S; Taylor, VI; Waterbury, JA1
Chen, S; Chopra, P; Emini, EA; Hahn, BH; Kappes, JC; McFarland, R; Piatak, M; Saag, MS; Shaw, GM; Yang, LC1
Goldman, ME; O'Brien, JA; Ostovic, D; Ruffing, TL; Schorn, TW; Siegl, PK; Smith, SJ1
Chen, IS; Dueweke, TJ; Poppe, SM; Pushkarskaya, T; Stevenson, M; Swaney, SM; Tarpley, WG; Zhao, JQ1
Byrnes, VW; Douglas, J; Emini, EA; Hildebrand, C; Kappes, JC; Lapidus, WI; Laskin, OL; Saag, MS; Schleif, WA; Whitley, RJ1
Byrnes, VW; Condra, JH; Long, WJ; Sardana, VV; Schlabach, AJ; Schleif, WA; Schneider, CL; Waterbury, JA; Wolanski, BS; Wolfgang, JA1
Davey, RT; Dewar, RL; Falloon, J; Haneiwich, SE; Kovacs, JA; Masur, H; Polis, MA; Reed, GF; Vasudevachari, MB; Walker, RE1
Blaschke, T; Campbell, TB; Collier, A; Kahn, J; Kuritzkes, DR; Messari, F; Phair, J; Pottage, JC; Rosandich, ME; Schooley, RT; Stein, DS1
Kilby, JM; Saag, MS1
Baumberger, C; Hirschel, B; Kinloch-de Loës, S; Pechère, M; Perrin, L; Rakik, A; Yerly, S1
Herold, ML; Lee, LL; Zacchei, AG1
Dornadula, G; Grobler, JA; Hazuda, DJ; Miller, MD; Rice, MR; Simcoe, AL1

Reviews

2 review(s) available for benzoxazoles and l-697661

ArticleYear
The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.
    Archives of virology. Supplementum, 1994, Volume: 9

    Topics: Antiviral Agents; Benzodiazepines; Benzoxazoles; Clinical Trials as Topic; Drug Resistance, Microbial; Genetic Variation; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Nevirapine; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase

1994
Clinical experience with non-nucleoside reverse transcriptase inhibitors: L-697,661 and nevirapine.
    Advances in experimental medicine and biology, 1996, Volume: 394

    Topics: Benzoxazoles; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase

1996

Trials

5 trial(s) available for benzoxazoles and l-697661

ArticleYear
Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high-level resistance to L-697,661, a nonnucleoside reverse transcriptase inhibitor.
    The Journal of infectious diseases, 1995, Volume: 171, Issue:5

    Topics: Adult; Antiviral Agents; Base Sequence; Benzoxazoles; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Microbial; Drug Therapy, Combination; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Molecular Sequence Data; Mutation; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Zidovudine

1995
Assessment of antiretroviral therapy by plasma viral load testing: standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Oct-01, Volume: 10, Issue:2

    Topics: Antiviral Agents; Benzoxazoles; Biomarkers; CD4 Lymphocyte Count; Double-Blind Method; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Immunoassay; Polymerase Chain Reaction; Prospective Studies; Pyridones; Reverse Transcriptase Inhibitors; RNA, Viral; Viremia; Zidovudine

1995
A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. L-697,661 Working Group.
    The New England journal of medicine, 1993, Oct-07, Volume: 329, Issue:15

    Topics: Adult; Antiviral Agents; Base Sequence; Benzoxazoles; CD4-Positive T-Lymphocytes; DNA, Viral; Double-Blind Method; Female; Follow-Up Studies; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Leukocyte Count; Male; Molecular Sequence Data; Pyridones; Reverse Transcriptase Inhibitors; Zidovudine

1993
Plasma viremia as a sensitive indicator of the antiretroviral activity of L-697,661.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jun-15, Volume: 90, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Benzoxazoles; beta 2-Microglobulin; Biomarkers; CD4 Antigens; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; HIV Core Protein p24; HIV Seropositivity; HIV-1; Humans; Male; Neoplasms; Pyridones; Time Factors; Viremia; Zidovudine

1993
Phase 1 study of combination therapy with L-697,661 and zidovudine. The ACTG 184 Protocol Team.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Aug-01, Volume: 12, Issue:4

    Topics: Adult; Antipyrine; Antiviral Agents; Base Sequence; Benzoxazoles; Cross-Over Studies; DNA Primers; DNA, Viral; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Genes, pol; Genotype; HIV Seropositivity; HIV-1; Humans; Male; Molecular Sequence Data; Pilot Projects; Pyridones; Reverse Transcriptase Inhibitors; Zidovudine

1996

Other Studies

15 other study(ies) available for benzoxazoles and l-697661

ArticleYear
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
    Journal of medicinal chemistry, 1992, Oct-16, Volume: 35, Issue:21

    Topics: Aminopyridines; Antiviral Agents; Benzoxazoles; Cells, Cultured; HIV Reverse Transcriptase; HIV-1; Pyridones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

1992
Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors.
    The Journal of biological chemistry, 1992, Sep-05, Volume: 267, Issue:25

    Topics: Amino Acid Sequence; Antiviral Agents; Azepines; Benzodiazepines; Benzoxazoles; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Imidazoles; Kinetics; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Pyridones; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship

1992
Possible toxicity associated with L-697,661 administration in a patient with AIDS.
    AIDS (London, England), 1992, Volume: 6, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Benzoxazoles; Humans; Male; Middle Aged; Pyridones; Reverse Transcriptase Inhibitors; Ulcer

1992
Mutational analysis of residue 190 of human immunodeficiency virus type 1 reverse transcriptase.
    Virology, 1994, May-01, Volume: 200, Issue:2

    Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Benzoxazoles; Delavirdine; DNA Mutational Analysis; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Imidazoles; Indoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Nevirapine; Piperazines; Pyridines; Pyridones; Quinoxalines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Selection, Genetic; Structure-Activity Relationship

1994
Effect of template secondary structure on the inhibition of HIV-1 reverse transcriptase by a pyridinone non-nucleoside inhibitor.
    Nucleic acids research, 1994, Apr-25, Volume: 22, Issue:8

    Topics: Animals; Antiviral Agents; Base Sequence; Benzoxazoles; DNA Primers; Electrophoresis, Polyacrylamide Gel; Globins; HIV Reverse Transcriptase; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Pyridones; Rabbits; Reverse Transcriptase Inhibitors; RNA, Viral; Templates, Genetic

1994
Enzymatic properties and sensitivity to inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with Glu-138-->Arg and Tyr-188-->His mutations.
    Antiviral research, 1994, Volume: 24, Issue:1

    Topics: Amino Acids; Antiviral Agents; Base Sequence; Benzodiazepines; Benzoxazoles; Binding, Competitive; Deoxyguanine Nucleotides; Dideoxynucleotides; Foscarnet; HIV Reverse Transcriptase; Humans; Imidazoles; Kinetics; Molecular Sequence Data; Mutation; Nevirapine; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sensitivity and Specificity

1994
Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
    FEBS letters, 1995, Feb-13, Volume: 359, Issue:2-3

    Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Benzoxazoles; Delavirdine; DNA Primers; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Indoles; Leucine; Molecular Sequence Data; Piperazines; Point Mutation; Proline; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase

1995
Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals.
    Journal of virology, 1995, Volume: 69, Issue:4

    Topics: Antiviral Agents; Benzoxazoles; Cell Compartmentation; Cell-Free System; DNA, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Virion; Virus Replication

1995
Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s.
    FEBS letters, 1995, Aug-14, Volume: 370, Issue:1-2

    Topics: Amino Acid Sequence; Antiviral Agents; Benzodiazepines; Benzoxazoles; Cloning, Molecular; Delavirdine; HIV Reverse Transcriptase; HIV-1; HIV-2; Imidazoles; Indoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nevirapine; Piperazines; Point Mutation; Pyridines; Pyridones; Recombinant Fusion Proteins; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tyrosine

1995
A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels.
    Life sciences, 1993, Volume: 52, Issue:3

    Topics: Administration, Oral; Animals; Benzoxazoles; Biological Assay; Chromatography, High Pressure Liquid; HIV Reverse Transcriptase; HIV-1; Macaca mulatta; Pyridones; Reverse Transcriptase Inhibitors

1993
A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, May-15, Volume: 90, Issue:10

    Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Benzoxazoles; Cloning, Molecular; Delavirdine; Drug Resistance; HIV Reverse Transcriptase; Imidazoles; Indoles; Molecular Sequence Data; Mutation; Nevirapine; Oligodeoxyribonucleotides; Piperazines; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase

1993
Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Benzoxazoles; DNA, Viral; Genetic Variation; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Nucleosides; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship

1993
Combined therapy with zidovudine and L-697,661 in primary HIV infection.
    AIDS (London, England), 1996, Volume: 10, Issue:11

    Topics: Adult; Anti-HIV Agents; Benzoxazoles; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; DNA, Viral; Drug Therapy, Combination; HIV Infections; Humans; Pyridones; Reverse Transcriptase Inhibitors; RNA, Viral; Viral Load; Viremia; Zidovudine

1996
High-performance liquid chromatographic method for the determination of an HIV-1 non-nucleoside reverse transcriptase inhibitor (L-696,229) in plasma samples from animals.
    Journal of chromatography. B, Biomedical applications, 1996, Oct-25, Volume: 685, Issue:2

    Topics: Animals; Antiviral Agents; Benzoxazoles; Chromatography, High Pressure Liquid; Circadian Rhythm; Cohort Studies; Female; HIV-1; Macaca mulatta; Male; Osmolar Concentration; Pyridones; Rats; Reproducibility of Results; Reverse Transcriptase Inhibitors; Spectrophotometry, Ultraviolet; Time Factors

1996
HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro.
    The Journal of biological chemistry, 2007, Mar-16, Volume: 282, Issue:11

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Benzoxazoles; Cyclopropanes; DNA; Dose-Response Relationship, Drug; Drug Resistance, Viral; Enzyme Inhibitors; HIV Reverse Transcriptase; In Vitro Techniques; Inhibitory Concentration 50; Ligands; Models, Genetic; Oxazines; Pyridones; Reverse Transcriptase Inhibitors; Stochastic Processes; Transcription, Genetic; Virus Replication

2007