Compounds > benzoxazoles
Page last updated: 2024-08-21

benzoxazoles and benzofuroxan

benzoxazoles has been researched along with benzofuroxan in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19906 (13.95)18.7374
1990's2 (4.65)18.2507
2000's10 (23.26)29.6817
2010's20 (46.51)24.3611
2020's5 (11.63)2.80

Authors

AuthorsStudies
Brocklehurst, K; Shipton, M1
Brocklehurst, K; Shipton, M; Stuchbury, T1
Belton, JG; Kessel, D1
Brocklehurst, K; Willenbrock, F1
Brocklehurst, K; Salih, E1
Ghosh, P; Ternai, B; Whitehouse, M1
Bosia, A; Di Stilo, A; Fruttero, R; Gasco, A; Ghigo, D; Medana, C; Visentin, S1
Giblin, D; Gross, ML; Haas, GW; Takakis, IM; Tsantali, GG1
Axenova, LN; Buneeva, OA; Ivanov, AS; Medvedev, AE; Pyatakova, NV; Severina, IS; Veselovsky, AV1
Fruttero, R; Galli, U; Gasco, A; Gervasio, G; Grosa, G; Rolando, B1
Cerecetto, H; Porcal, W1
Aguirre, G; Barreiro, EJ; Boiani, L; Boiani, M; Castellano, EE; Cerecetto, H; Denicola, A; Di Maio, R; González, M; Piro, OE; Porcal, W; Sant'Anna, CM1
Aguirre, G; Basombrío, MA; Boiani, L; Boiani, M; Campillo, NE; Castro, A; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; Davies, C; González, M; Hernández, P; Krauth-Siegel, RL; Paez, JA; Porcal, W1
Boiani, M; Cerecetto, H; Fagiolino, P; Gerpe, A; González, M; Merlino, A; Porcal, W1
Arredondo, C; Basombrío, MA; Boiani, L; Boiani, M; Cerecetto, H; Davies, C; Gerpe, A; González, M; Merlino, A; Pacheco, JP; Porcal, W1
Boiani, L; Boiani, M; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; Ferreira, A; González, M; Hernández, P; Olea-Azar, C; Porcal, W1
Boiani, M; Cabrera, M; Cerecetto, H; de Cerain, AL; Ferreira, A; Gerpe, A; González, M; Hernández, P; Lavaggi, ML; Merlino, A; Monge, A; Porcal, W1
Benitez, D; Boiani, L; Castro, D; Cerecetto, H; Gil, C; González, M; Hernández, P; Merlino, A; Olea-Azar, C; Porcal, W1
Ayala, AP; Cerecetto, H; Ellena, J; González, M; Martins, FT; Porcal, W1
Boiani, L; Boiani, M; Cerecetto, H; Denicola, A; González, M; Hernández, P; Piacenza, L1
de Carvalho, PS; Gambero, A; Maróstica, M; Pedrazzoli, J1
Goumont, R; Kletsky, ME; Kurbatov, SV; Minkin, VI; Steglenko, DV; Tatarov, AV; Terrier, F1
Cechinel, CA; Ishii, M; Jorge, SD; Masunari, A; Palace-Berl, F; Pasqualoto, KF; Tavares, LC1
Barresi, E; Cosconati, S; Da Settimo, F; Di Maro, S; La Motta, C; Marinelli, L; Marini, AM; Novellino, E; Salerno, S; Sartini, S; Simorini, F; Taliani, S1
Chugunova, EA; Goumont, R; Jovené, C1
Berra, CM; Bosch, RV; Ferreira, AK; Ishii, M; Jorge, SD; Maria, DA; Mesquita Pasqualoto, KF; Palace-Berl, F; Tavares, LC1
Alexandre de Azevedo, R; Barbuto, JA; Bydlowski, SP; Ferreira, AK; Jorge, SD; Levy, D; Pizzo, CR; Rodrigues, CP; Salomon, MA; Teixeira, SF1
Boga, C; Burilov, A; Chugunova, E; Cino, S; Khmelevtsova, L; Kostina, N; Mazzanti, A; Micheletti, G; Sazykin, I; Sazykina, M1
Chu, X; Duan, W; Hou, J; Li, J; Li, X; Xu, W; Zhang, J; Zhang, Y1
Bosquesi, PL; Chung, MC; Marcondes, S; Melchior, AC; Pavan, AR; Pires, ME; Rosseto, LA; Santos, JL1
Azevedo, RA; Farias, CF; Ferreira, AK; Figueiredo, CR; Girola, N; Jorge, SD; Massaoka, MH; Tavares, LC; Travassos, LR1
Burilov, A; Chugunova, E; Dobrynin, A; Gavrilov, N; Karchava, S; Karpenko, A; Mirina, E; Mukhamatdinova, R; Sazykin, I; Sazykina, M; Zhuravleva, M1
Azevedo, RA; Barbuto, JA; de Sá Junior, PL; Farias, CF; Ferreira, AC; Ferreira, AK; Figueiredo, CR; Jorge, SD; Kruyt, FA; Palace-Berl, F; Pasqualoto, KF; Rodrigues, CP; Salomón, MA; Tavares, LC; Turra, KM1
Akylbekov, N; Bulatova, A; Burilov, A; Chugunova, E; Dobrynin, A; Gavrilov, N; Kulik, N; Syakaev, V; Voloshina, A; Zobov, V1
Burilov, AR; Chugunova, EA1
Mendonça-Junior, FJ; Scotti, L; Scotti, MT1
de Almeida, L; de Andrade, CR; Dos Santos, JL; Dutra, LA; Fonseca, JNVD; Graminha, MAS; Imamura, KB; Nascimento, RFQ; Passalacqua, TG1
Duan, Y; Huang, Y; Mao, J; Wang, X; Xu, W; Zhang, H; Zhang, J1
Buravchenko, GI; Dorovatovskii, PV; Korlukov, AА; Scherbakov, AM; Shchekotikhin, AE1
Akylbekov, N; Appazov, N; Burilov, A; Chugunova, E; Dobrynin, A; Gazizov, A; Gerasimova, T; Gildebrant, A; Gogoleva, O; Gorshkov, V; Gumerova, S; Karchava, S; Khamatgalimov, A; Klimova, M; Sapunova, A; Sazykin, I; Sazykina, M; Voloshina, A1
Campos, DL; Da Silva, IC; Dos Santos, JL; Fernandes, GFS; Pavan, AR; Pavan, FR; Prates, JLB1
Amerhanova, S; Boga, C; Burilov, A; Chugunova, E; Gerasimova, T; Gilfanova, A; Islamov, D; Lyubina, A; Micheletti, G; Syakaev, V; Telese, D; Tulesinova, A; Usachev, K; Voloshina, A1
Akylbekov, N; Appazov, N; Babaev, V; Burilov, A; Chugunova, E; Gazizov, A; Islamov, D; Kharlamov, S; Syakaev, V; Tulesinova, A; Usachev, K; Zhapparbergenov, R1

Reviews

4 review(s) available for benzoxazoles and benzofuroxan

ArticleYear
Benzofurazans and benzofuroxans: biochemical and pharmacological properties.
    Medicinal research reviews, 1981,Summer, Volume: 1, Issue:2

    Topics: Amines; Animals; Antifungal Agents; Antineoplastic Agents; Benzoxazoles; Chemical Phenomena; Chemistry; DNA; Drug Interactions; Guinea Pigs; Herbicides; Lymphocyte Activation; Mice; Mutagens; Proteins; Rabbits; Rats; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Vasodilation

1981
Pharmacological properties of furoxans and benzofuroxans: recent developments.
    Mini reviews in medicinal chemistry, 2005, Volume: 5, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Benzoxazoles; Calcium Channel Blockers; Humans; Oxadiazoles; Vasodilator Agents

2005
The properties and the use of substituted benzofuroxans in pharmaceutical and medicinal chemistry: a comprehensive review.
    Mini reviews in medicinal chemistry, 2013, Jun-01, Volume: 13, Issue:8

    Topics: Animals; Benzoxazoles; Chemistry, Pharmaceutical; Humans

2013
Novel Structural Hybrids on the Base of Benzofuroxans and Furoxans. Mini-Review.
    Current topics in medicinal chemistry, 2017, Volume: 17, Issue:9

    Topics: Animals; Benzoxazoles; Humans; Molecular Structure; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Prodrugs

2017

Other Studies

39 other study(ies) available for benzoxazoles and benzofuroxan

ArticleYear
Benzofuroxan as a thiol-specific reactivity probe. Kinetics of its reactions with papain, ficin, bromelain and low-molecular-weight thiols.
    The Biochemical journal, 1977, Dec-01, Volume: 167, Issue:3

    Topics: Benzoxazoles; Binding Sites; Bromelains; Cyclic N-Oxides; Endopeptidases; Ficain; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Models, Chemical; Papain; Sulfhydryl Compounds

1977
Evaluation of benzofuroxan as a chromophoric oxidizing agent for thiol groups by using its reactions with papain, ficin, bromelain and low-molecular-weight thiols.
    The Biochemical journal, 1977, Mar-01, Volume: 161, Issue:3

    Topics: Benzoxazoles; Bromelains; Cyclic N-Oxides; Endopeptidases; Ficain; Kinetics; Oxidation-Reduction; Oximes; Papain; Spectrum Analysis; Sulfhydryl Reagents

1977
Effects of 4-nitrobenzofurazans and their N-oxides on synthesis of protein and nucleic acid by murine leukemia cells.
    Cancer research, 1975, Volume: 35, Issue:12

    Topics: Animals; Benzoxazoles; Cells, Cultured; Cyclic N-Oxides; DNA, Neoplasm; Leukemia L1210; Leukemia, Experimental; Neoplasm Proteins; Nitro Compounds; Oxadiazoles; Phosphates; RNA, Neoplasm; Structure-Activity Relationship; Thymidine; Uridine

1975
Chemical evidence for the pH-dependent control of ion-pair geometry in cathepsin B. Benzofuroxan as a reactivity probe sensitive to differences in the mutual disposition of the thiolate and imidazolium components of cysteine proteinase catalytic sites.
    The Biochemical journal, 1986, Aug-15, Volume: 238, Issue:1

    Topics: Animals; Benzoxazoles; Bromelains; Cathepsin B; Cattle; Hydrogen-Ion Concentration; Ions; Kinetics; Liver; Papain; Rats; Spleen; Sulfhydryl Reagents

1986
Investigation of the catalytic site of actinidin by using benzofuroxan as a reactivity probe with selectivity for the thiolate-imidazolium ion-pair systems of cysteine proteinases. Evidence that the reaction of the ion-pair of actinidin (pKI 3.0, pKII 9.6
    The Biochemical journal, 1983, Sep-01, Volume: 213, Issue:3

    Topics: Benzoquinones; Benzoxazoles; Binding Sites; Chemical Phenomena; Chemistry; Cysteine Endopeptidases; Deuterium; Deuterium Oxide; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Oximes; Papain; Sulfhydryl Compounds; Water

1983
NO donor and biological properties of different benzofuroxans.
    Pharmaceutical research, 1999, Volume: 16, Issue:6

    Topics: Animals; Aorta; Benzoxazoles; Cyclic GMP; Cytosol; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Donors; Norepinephrine; Rats; Rats, Wistar; Structure-Activity Relationship; Tumor Cells, Cultured; Vasodilation

1999
Mass spectra of 1,2-alkylenedioxy-substituted and related benzofurazans and benzofuroxans: differentiation between linear and angular isomers.
    Journal of mass spectrometry : JMS, 1999, Volume: 34, Issue:11

    Topics: Benzoxazoles; Gas Chromatography-Mass Spectrometry; Isomerism; Molecular Structure

1999
Nonselective inhibition of monoamine oxidases A and B by activators of soluble guanylate cyclase.
    Biochemistry. Biokhimiia, 2003, Volume: 68, Issue:9

    Topics: Animals; Benzoxazoles; Binding Sites; Guanylate Cyclase; Heterocyclic Compounds, 3-Ring; Humans; Ligands; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitro Compounds; Oxides; Protein Conformation; Rats; Solubility

2003
Identification of 2,3-diaminophenazine and of o-benzoquinone dioxime as the major in vitro metabolites of benzofuroxan.
    Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:4

    Topics: Animals; Benzoquinones; Benzoxazoles; Cells, Cultured; Cytosol; Male; Microsomes, Liver; Models, Biological; Models, Chemical; Phenazines; Rats; Rats, Wistar

2004
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: quantitative structure-activity relationship studies.
    Bioorganic & medicinal chemistry, 2005, Dec-01, Volume: 13, Issue:23

    Topics: Animals; Benzoxazoles; Electrons; Magnetic Resonance Spectroscopy; Molecular Structure; Nifurtimox; Quantitative Structure-Activity Relationship; Temperature; Trypanocidal Agents; Trypanosoma cruzi

2005
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.
    Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24

    Topics: Animals; Antibodies, Protozoan; Benzoxazoles; Cell Line; Chagas Disease; Cysteine Endopeptidases; Female; Glutathione; Humans; Macrophages; Mice; Models, Molecular; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxygen Consumption; Protozoan Proteins; Stereoisomerism; Structure-Activity Relationship; Sulfones; Trypanocidal Agents; Trypanosoma cruzi; Vinyl Compounds

2007
Development of a HPLC method for the determination of antichagasic phenylethenylbenzofuroxans and its major synthetic secondary products in the chemical production processes.
    Journal of pharmaceutical and biomedical analysis, 2008, May-12, Volume: 47, Issue:1

    Topics: Antiprotozoal Agents; Benzoxazoles; Chagas Disease; Chromatography, High Pressure Liquid

2008
In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:10

    Topics: Acute Disease; Animals; Antibodies, Protozoan; Benzoxazoles; Chagas Disease; Disease Models, Animal; Female; Mice; Parasitemia; Treatment Outcome; Trypanosoma cruzi

2008
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.
    Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14

    Topics: Animals; Benzoxazoles; Cysteine Endopeptidases; Glutathione; Hydrazones; Macrophages; Mice; Oxidative Stress; Protozoan Proteins; Spermidine; Trypanocidal Agents; Trypanosoma cruzi

2008
Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction.
    Toxicology letters, 2009, Oct-28, Volume: 190, Issue:2

    Topics: Animals; Benzoxazoles; Biotransformation; Cell Survival; Coloring Agents; Comet Assay; Cricetinae; Cytosol; Female; Humans; Microsomes, Liver; Mutagenicity Tests; Mutagens; Rats; Rats, Wistar; Salmonella typhimurium; Tetrazolium Salts; Thiazoles; Trypanocidal Agents

2009
Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:12

    Topics: Animals; Benzoxazoles; Inhibitory Concentration 50; Macrophages; Mice; Molecular Structure; Organophosphorus Compounds; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi

2009
Structural relationships in the solid state of the anti-chagas agent (E)-phenylethenylbenzofuroxan.
    Molecular diversity, 2010, Volume: 14, Issue:4

    Topics: Antiprotozoal Agents; Benzoxazoles; Chagas Disease; Crystallography, X-Ray; Cyclic N-Oxides; Humans; Models, Biological; Models, Molecular; Molecular Structure; Oxadiazoles; Phase Transition; Spectrum Analysis, Raman; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction

2010
Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?
    Biochemical pharmacology, 2010, Jun-15, Volume: 79, Issue:12

    Topics: Benzoxazoles; Cells, Cultured; Cyclic N-Oxides; Membrane Potentials; Mitochondria; Molecular Structure; Nifurtimox; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Oxygen; Trypanocidal Agents; Trypanosoma cruzi

2010
Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinoprostone; Edema; Humans; Intestinal Mucosa; Male; Nitric Oxide; Rats; Rats, Wistar; Ulcer

2010
The stepwise Diels-Alder reaction of 4-nitrobenzodifuroxan with Danishefsky's diene.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Jun-27, Volume: 17, Issue:27

    Topics: Benzoxazoles; Butadienes; Crystallography, X-Ray; Cyclic N-Oxides; Cyclization; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Quantum Theory; Stereoisomerism; Trimethylsilyl Compounds

2011
Novel benzofuroxan derivatives against multidrug-resistant Staphylococcus aureus strains: design using Topliss' decision tree, synthesis and biological assay.
    Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16

    Topics: Anti-Bacterial Agents; Benzoxazoles; Decision Trees; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Sensitivity and Specificity; Software; Staphylococcal Infections; Structure-Activity Relationship

2011
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.
    Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23

    Topics: Animals; Benzoxazoles; Cardiovascular Diseases; Diabetes Complications; Humans; Liver; Models, Molecular; Molecular Docking Simulation; Rats

2012
Ligand-based design, synthesis, and experimental evaluation of novel benzofuroxan derivatives as anti-Trypanosoma cruzi agents.
    European journal of medicinal chemistry, 2013, Volume: 64

    Topics: Benzoxazoles; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Fibroblasts; Humans; Ligands; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Quantitative Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2013
Synergistic anti-tumor effects of the combination of a benzofuroxan derivate and sorafenib on NCI-H460 human large cell lung carcinoma cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:8

    Topics: Antineoplastic Agents; Benzoxazoles; Carcinoma, Non-Small-Cell Lung; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Sorafenib

2014
Synthesis and antimicrobial activity of novel structural hybrids of benzofuroxan and benzothiazole derivatives.
    European journal of medicinal chemistry, 2015, Mar-26, Volume: 93

    Topics: Anti-Bacterial Agents; Benzothiazoles; Benzoxazoles; Chemistry Techniques, Synthetic; Escherichia coli; Genes, Bacterial; Microbial Sensitivity Tests; Structure-Activity Relationship; Vibrio

2015
Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity.
    Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

    Topics: Antineoplastic Agents; Benzoxazoles; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; HCT116 Cells; Hemoglobins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Nitric Oxide; Oxadiazoles

2015
Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events.
    Molecules (Basel, Switzerland), 2015, Oct-07, Volume: 20, Issue:10

    Topics: Animals; Benzoxazoles; Collagen; Disease Models, Animal; Epinephrine; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism

2015
Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo.
    BMC cancer, 2015, Oct-27, Volume: 15

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzoxazoles; Cell Line, Tumor; HeLa Cells; Humans; Male; Melanoma, Experimental; Membrane Proteins; Mice; Mice, Inbred C57BL; Oncogene Protein v-akt; Proto-Oncogene Proteins; Signal Transduction

2015
Synthesis of New 'Hybrid' Compounds Based on Benzofuroxans and Aminoalkylnaphthalimides.
    Chemical biology & drug design, 2016, Volume: 87, Issue:4

    Topics: Benzoxazoles; Crystallography, X-Ray; Naphthalimides; Proton Magnetic Resonance Spectroscopy

2016
BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity.
    Toxicology and applied pharmacology, 2016, Mar-15, Volume: 295

    Topics: Animals; Apoptosis; Benzoxazoles; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 4; Flow Cytometry; Hydrazines; Melanoma, Experimental; Mice; Microscopy, Fluorescence; Molecular Docking Simulation; Oxadiazoles; Proto-Oncogene Proteins B-raf

2016
Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones.
    European journal of medicinal chemistry, 2016, Jun-30, Volume: 116

    Topics: Anti-Bacterial Agents; Bacteria; Benzoxazoles; Chemistry Techniques, Synthetic; Drug Design; Fluoroquinolones; Hemolysis; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Structure-Activity Relationship

2016
Editorial (Thematic Issue: Hybrid Compounds as Multitarget Agents in Medicinal Chemistry - Part II).
    Current topics in medicinal chemistry, 2017, Volume: 17, Issue:9

    Topics: Alzheimer Disease; Anti-Infective Agents; Benzoxazoles; Chemistry, Pharmaceutical; Drug Discovery; Humans; Neoplasms; Neuroprotective Agents; Oxadiazoles; Polypharmacology

2017
In vivo antileishmanial activity and histopathological evaluation in Leishmania infantum infected hamsters after treatment with a furoxan derivative.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95

    Topics: Amphotericin B; Animals; Antiprotozoal Agents; Benzoxazoles; Biomarkers; Cricetinae; Kidney; Leishmania infantum; Leishmaniasis, Visceral; Liver; Macrophages; Male; Mice; Nitric Oxide; Spleen; Treatment Outcome

2017
Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity.
    Bioorganic & medicinal chemistry, 2018, 08-15, Volume: 26, Issue:15

    Topics: Animals; Antineoplastic Agents; Benzoxazoles; Binding Sites; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Molecular Docking Simulation; Neoplasms; Neovascularization, Physiologic; Nitric Oxide; Pyrrolidines; Structure-Activity Relationship

2018
Revision of the Regioselectivity of the Beirut Reaction of Monosubstituted Benzofuroxans with Benzoylacetonitrile. 6-Substituted quinoxaline-2-carbonitrile 1,4- dioxides: Structural Characterization and Estimation of Anticancer Activity and Hypoxia Select
    Current organic synthesis, 2020, Volume: 17, Issue:1

    Topics: Acetonitriles; Antineoplastic Agents; Benzoxazoles; Cell Hypoxia; Cell Proliferation; Cyclic N-Oxides; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Quinoxalines

2020
Design of Novel 4-Aminobenzofuroxans and Evaluation of Their Antimicrobial and Anticancer Activity.
    International journal of molecular sciences, 2020, Nov-05, Volume: 21, Issue:21

    Topics: Anti-Infective Agents; Antineoplastic Agents; Benzoxazoles; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Drug Screening Assays, Antitumor; Drugs, Investigational; HeLa Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Benzofuroxan Derivatives as Potent Agents against Multidrug-Resistant Mycobacterium tuberculosis.
    ChemMedChem, 2021, 04-20, Volume: 16, Issue:8

    Topics: Antitubercular Agents; Benzoxazoles; Drug Design; Drug Resistance, Multiple; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Structure-Activity Relationship

2021
Novel Hybrid Compounds Containing Benzofuroxan and Aminothiazole Scaffolds: Synthesis and Evaluation of Their Anticancer Activity.
    International journal of molecular sciences, 2021, Jul-13, Volume: 22, Issue:14

    Topics: Antineoplastic Agents; Apoptosis; Benzoxazoles; Cell Proliferation; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles; Uterine Cervical Neoplasms

2021
The Reactivity of Azidonitrobenzofuroxans towards 1,3-Dicarbonyl Compounds: Unexpected Formation of Amino Derivative via the Regitz Diazo Transfer and Tautomerism Study.
    International journal of molecular sciences, 2021, Sep-06, Volume: 22, Issue:17

    Topics: Animals; Azo Compounds; Benzoxazoles; Chemistry, Pharmaceutical; Cycloaddition Reaction; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Molecular Structure; Stereoisomerism

2021