benzothiophene has been researched along with thiophenes in 285 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (3.16) | 18.7374 |
| 1990's | 13 (4.56) | 18.2507 |
| 2000's | 88 (30.88) | 29.6817 |
| 2010's | 140 (49.12) | 24.3611 |
| 2020's | 35 (12.28) | 2.80 |
| Authors | Studies |
|---|---|
| Eaton, RW; Nitterauer, JD | 1 |
| Bihun, C; Chu, I; Davis, H; Lecavalier, P; Liteplo, R; Poon, R; Yagminas, A | 1 |
| Butera, ST; Coligan, JE; Critchfield, JW; Folks, TM | 1 |
| Bastian, JA; Briggs, SL; Buben, JA; Chirgadze, NY; Clawson, DK; Denney, ML; Giera, DD; Gifford-Moore, DS; Harper, RW; Hauser, KL; Klimkowski, VJ; Kohn, TJ; Lin, HS; McCowan, JR; Palkowitz, AD; Sall, DJ; Smith, GF; Takeuchi, K; Thrasher, KJ; Tinsley, JM; Utterback, BG; Yan, SC; Zhang, M | 1 |
| Chu, I; Davis, H; Elwin, J; Lecavalier, P; Park, G; Poon, R; Valli, VE; Yagminas, A | 1 |
| Buchanan, S; Gilbert, SC; McRoberts, A; Morton, J; Oldfield, C | 1 |
| Briggs, SL; Chirgadze, NY; Clawson, DK; Gifford-Moore, DS; Klimkowski, VJ; McCowan, JR; Sall, DJ; Smith, GF; Wikel, JH | 1 |
| Bastian, JA; Chirgadze, N; Denney, ML; Gifford-Moore, DS; Sall, DJ; Smith, GF; Wikel, JH | 1 |
| Britton, TC; Bruns, RF; Gehlert, DR; Hipskind, PA; Schober, DA; Spinazze, PG; Zarrinmayeh, H; Zimmerman, DM | 1 |
| Denney, ML; Gifford-Moore, DS; Kohn, TJ; McCowan, JR; Sall, DJ; Smith, GF; Takeuchi, K | 1 |
| Bailey, DL; Bastian, JA; Briggs, SL; Chirgadze, NY; Clawson, DK; Denney, ML; Gifford-Moore, DS; Harper, RW; Johnson, LM; Klimkowski, VJ; Kohn, TJ; Lin, HS; McCowan, JR; Richett, ME; Sall, DJ; Smith, AJ; Smith, GF; Snyder, DW; Takeuchi, K; Utterback, BG; Yan, SC; Zhang, M | 1 |
| Brown, R; Gilbert, SC; Goodfellow, M; Kim, SB; Oldfield, C | 1 |
| Duval, C; Galey, JB; Lagrange, A; Philippe, M; Régnier, M; Schmidt, R; Tuloup, R | 1 |
| Briggs, SL; Chirgadze, NY; Clawson, DK; Sall, DJ; Schevitz, RW; Smith, GF; Zhang, M | 1 |
| Kurane, R; Matsui, T; Onaka, T; Suzuki, M; Tanaka, Y; Tezuka, T | 1 |
| Ishii, Y; Kobayashi, M; Koizumi, K; Konishi, J; Ohta, Y; Okada, H; Onaka, T; Suzuki, M; Takaki, M | 1 |
| Ishii, Y; Konishi, J; Onaka, T; Suzuki, M | 1 |
| Gifford-Moore, DS; Harper, RW; Kohn, TJ; Lin, HS; Richett, ME; Sall, DJ; Smith, GF; Takeuchi, K; Zhang, M | 1 |
| Flynn, BL; Hamel, E; Verdier-Pinard, P | 1 |
| Makino, M | 1 |
| De, AK; Ganguly, T | 1 |
| Kurane, R; Maruhashi, K; Matsui, T; Onaka, T; Tanaka, Y | 1 |
| Hirasawa, K; Konishi, J; Kurane, R; Maruhashi, K; Matsui, T; Tanaka, Y | 1 |
| Anderson, PW; Barrett-Connor, E; Cox, DA; Harper, K; Mosca, L; O'Gorman, J; Sarkar, S | 1 |
| Annweiler, E; Meckenstock, RU; Michaelis, W | 1 |
| Kurane, R; Maruhashi, K; Matsui, T; Onaka, T | 1 |
| Alonso, MM; Encío, I; Gil, M; Martínez-Merino, V; Migliaccio, M | 1 |
| Basu, C; De, A; Ganguly, T; Kamila, S; Misra, T | 1 |
| Arensdorf, JJ; DiGrazia, PM; Loomis, AK; Monticello, DJ; Pienkos, PT | 1 |
| Bischoff, SF; Feuerbach, D; Floersheim, P; Nozulak, J; Schoeffter, P; Schopfer, U | 1 |
| Hellou, J; Meade, JD; Patel, TR | 1 |
| Kakizono, T; Nilwarangkoon, S; Nuchfoang, S; Sarangbin, S; Watanapokasin, Y | 1 |
| Konishi, J; Kurane, R; Maruhashi, K; Matsui, T; Tanaka, Y | 1 |
| Furuya, T; Ishii, Y; Kino, K; Kirimura, K; Sato, R; Usami, S | 1 |
| Becchi, M; García, CL; Grenier-Loustalot, MF; Païsse, O; Szymanskit, R | 1 |
| Kurane, R; Maruhashi, K; Matsui, T; Noda, K; Tanaka, Y | 1 |
| Ishii, Y; Konishi, J; Maruhashi, K; Onaka, T | 1 |
| Adler, M; Biancalana, S; Kochanny, MJ; Light, DR; Rumennik, G; Whitlow, M; Ye, B | 1 |
| De Nanteuil, G; Lila-Ambroise, C; Rupin, A; Vallez, MO; Verbeuren, TJ | 1 |
| Kochanny, M; Lentz, D; Liang, AM; Light, DR; Morser, J; Post, J; Rumennik, G; Snider, M; Trinh, L | 1 |
| Henry, AA; Matsuda, S; Romesberg, FE; Schultz, PG | 1 |
| Alonso, MM; Asumendi, A; Encío, IJ; Gil, MJ; Martínez-Merino, V; Migliaccio, M; Villar, J | 1 |
| Audinot, V; Bennejean, C; Boutin, JA; Chavatte, P; Delagrange, P; Ferry, G; Lesieur, D; Mesangeau, C; Renard, P; Yous, S | 1 |
| GOETTSCH, RW; WIESE, GA | 1 |
| LEWIS, JJ; MARTIN-SMITH, M; MUIR, TC; NANJAPPA, SN; REID, ST | 1 |
| BONACINA, F; D ALO, F; MASSERINI, A | 1 |
| CAMPAIGNE, E; CARLSON, G; NEISS, ES; WEINBERG, ED | 1 |
| Grossman, MJ; Prince, RC | 1 |
| Koide, Y; Masaki, H; Mizuno, Y; Murakami, A; Satoh, S; Takahashi, A; Tatui, A | 1 |
| Aldana, I; Erviti, O; Galiano, S; Juanenea, L; Monge, A; Moreno, A; Pérez, S | 1 |
| Encio, I; Gil, MJ; Martinez-Merino, V; Migliaccio, M; Villar, R | 1 |
| Garavelas, A; Glen, RC; Martin, GR; Maxwell, M; Moloney, GP | 1 |
| Adrian, MD; Bryant, HU; Geiser, AG; Shetler, PK; Wallace, OB | 1 |
| Akhmedov, NG; Katritzky, AR; Rostek, CJ; Steel, PJ; Wang, M | 1 |
| Calhelha, RC; Estevinho, LM; Ferreira, IC; Queiroz, MJ | 1 |
| Arvin, E; Eilersen, AM; Henze, M | 1 |
| Furuya, T; Ishii, Y; Kino, K; Kirimura, K; Kozaki, S | 1 |
| Li, J; Liu, B; Wang, M; Wu, X; Xie, Y; Xu, G; Yan, X; Yang, C | 1 |
| Evans, CA; Fries, HE; Ward, KW | 1 |
| Alves, L; Gírio, FM; Matos, J; Mesquita, E; Rodrigues, C; Salgueiro, R | 1 |
| Douville, J; Espinosa, E; Faure, S; Guilard, R; Harvey, PD; Stern, C | 1 |
| David, E; Fournier dit Chabert, J; Lemaire, M; Pellet-Rostaing, S; Perrin, J | 1 |
| Baraldi, PG; Borgatti, M; Carrion, MD; Gambari, R; Heilmann, J; Iaconinoto, MA; Romagnoli, R; Tabrizi, MA | 1 |
| Hayward, TC; Thurbide, KB | 1 |
| Basso, G; Disarò, S; Fortunato, E; Queiroz, MJ; Salvador, A; Vedaldi, D; Viola, G | 1 |
| Begouin, A; Estevinho, LM; Ferreira, IC; Kirsch, G; Queiroz, MJ; Vilas-Boas, M | 1 |
| Deschamps, J; Krajewski, K; Parrish, D; Pathak, VK; Roller, PP; Zhang, Y | 1 |
| Ballesteros, A; Barluenga, J; González, JM; Merino, I; Vázquez-Villa, H | 1 |
| Asano, K; Gunam, IB; Hirano, M; Sone, T; Tomita, F; Yaku, Y; Yamamura, K | 1 |
| Nakamura, I; Sato, T; Yamamoto, Y | 1 |
| Bolton, JL; Liu, H; Thatcher, GR | 1 |
| Calhelha, RC; De Gaetano, Y; Estevinho, LM; Ferreira, IC; Kirsch, G; Queiroz, MJ | 1 |
| Lee, K; Li, GQ; Li, H; Li, SS; Liang, FL; Liu, RL; Ma, T | 1 |
| Chang, YS; Chung, JK; Ganesha, RB; Jeong, JM; Kim, HW; Kim, YJ; Lee, DS; Lee, MC; Lee, YS | 1 |
| Andersson, JT; Fedorak, PM; Foght, JM; Gray, MR; Kirkwood, KM | 1 |
| Anxolabéhère-Mallart, E; Frank, P; George, SD; Hedman, B; Hodgson, KO | 1 |
| Cooperwood, JS; Khan, MO; Musa, MA | 1 |
| Da Settimo, F; Martini, C; Montali, M; Taliani, S; Trincavelli, ML | 1 |
| Al-Bayati, RH; Aouad, M; Rezki, N; Sharba, AH | 1 |
| Oshima, K; Yorimitsu, H; Yoshida, S | 1 |
| Dahlberg, WK; Fleming, JC; Hubbs, JL; Hughes, BL; Kral, AM; Middleton, RE; Miller, TA; Secrist, JP; Szewczak, AA; Zhou, H | 1 |
| BLICKE, FF; SHEETS, DG | 1 |
| Altamura, M; D'Andrea, P; Ettorre, A; Fattori, D; Giuliani, S; Madami, A; Meini, S; Porcelloni, M; Rossi, C; Sisto, A | 1 |
| Abd el-Salam, OM; el-Batran, S; el-Shenawy, SM; Fakhr, IM; Radwan, MA | 1 |
| Begouin, A; Begouin, JM; Kirsch, G; Oliveira, JF; Pinto, E; Queiroz, MJ; Vale-Silva, LA | 1 |
| ALBISETTI, CJ; BORDWELL, FG | 1 |
| McCLELLAND, EW; STAMMERS, DW | 1 |
| ELLIOTT, DF; FULLER, AT; HARINGTON, CR | 1 |
| Ashgodom, RT; Bolton, JL; Choi, Y; Kastrati, I; Lantvit, DD; Overk, CR; Qin, Z; Thatcher, GR; van Breemen, RB | 1 |
| Arai, Y; Doi, T; Hiroya, K; Inamoto, K | 1 |
| Deng, Z; Gai, Z; Wang, X; Xu, P; Yu, B | 1 |
| Calhelha, RC; Pinto, E; Queiroz, MJ; São-José Nascimento, M; Vale-Silva, LA | 1 |
| Cao, Y; Liu, N; Pei, J; Peng, J; Wang, J; Wang, L; Zhou, Y | 1 |
| Abreu, RM; Ferreira, IC; Queiroz, MJ | 1 |
| Lautens, M; Tseng, NW | 1 |
| Grossert, JS; Herrera, LC; Ramaley, L | 1 |
| El Bassi, L; Matsui, T; Namihira, T; Oku, H; Shinzato, N | 1 |
| Li, GQ; Li, SS; Liang, FL; Liu, RL; Ma, T | 1 |
| Barbarella, G; Caria, S; Favaretto, L; Kajzar, F; Murgia, M; Rãu, I; Zamboni, R | 1 |
| Ahn, K; Beidler, D; Cravatt, BF; Dunbar, JB; Fay, L; Gregory, T; Johnson, DS; Kesten, S; Lazerwith, SE; Liimatta, M; Morris, M; Nomanbhoy, TK; Smith, S; Song, Y; Stiff, C | 1 |
| Ikeda, M; Kashiki, T; Kohara, M; Kuwabara, H; Miyazaki, E; Shinamura, S; Takimiya, K | 1 |
| Avery, A; Boyd, EA; Brunton, SA; Buxton, D; di Lucrezia, R; Guicherit, OM; Kruse, LI; MacKinnon, CH; Park, Y; Price, S; Rubin, LL; Stibbard, JH | 1 |
| Ila, H; Junjappa, H; Singh, PP; Yadav, AK | 1 |
| Anderson, DR; Caspers, N; Kurumbail, RG; Long, SA; Mahoney, MW; Meyers, MJ; Mourey, RJ; Parikh, MD; Pierce, BS; Poda, GI | 1 |
| Anderson, DR; Caspers, N; Kurumbail, RG; Long, SA; Mahoney, MW; Meyers, MJ; Mourey, RJ; Pierce, BS; Poda, GI | 1 |
| Braunger, JA; Bryan, CS; Lautens, M | 1 |
| Aureggi, V; Bryan, CS; Lautens, M; Newman, SG | 1 |
| Buchet, R; Chang, L; Lemaire, M; Li, L; Liger, F; Pellet-Rostaing, S; Wu, Y | 1 |
| Debi, TR; Gopinath, P; Muraleedharan, KM; Nilaya, S; Ramkumar, V | 1 |
| Isloor, AM; Kalluraya, B; Sridhar Pai, K | 1 |
| Altamura, M; Dimoulas, T; Fedi, V; Gensini, M; Giannotti, D; Giuliani, S; Guidi, A; Harmat, NJ; Maggi, CA; Meini, S; Nannicini, R; Pasqui, F; Tramontana, M; Triolo, A | 1 |
| Cho, CH; Larock, RC; Neuenswander, B | 1 |
| Ayele, T; Barry, J; Baumgartner, C; Beck, R; Blackney, M; Blench, T; Burd, A; Buxton, S; Chahwala, S; Chander, C; Cheung, C; Dagostin, C; Giddings, A; Holthoff, HP; Joshi, R; Malic, M; Marlin, F; Murray, E; Sajad, M; Shaikh, S; Wang, S | 1 |
| Ayele, T; Beck, R; Blackney, M; Blench, T; Burd, A; Buxton, S; Chahwala, S; Chander, C; Holland, R; Malic, M; Merette, S; Shaikh, S; Wang, S; Watts, A; Zhao, L | 1 |
| Beaton, G; Bradbury, MJ; Coon, T; Crowe, PD; Gross, RS; Hernandez, LM; Hoare, SR; Jovic, F; Li, BF; Madan, A; Malany, S; Marinkovic, D; Moree, WJ; O'Brien, Z; Petroski, RE; Sacaan, A; Tucci, FC; Wang, H; Wen, J; Yu, J | 1 |
| Mitra, I; Roy, K; Saha, A | 1 |
| Ahmed, T; Antonow, D; Dawood, I; Haque, MR; Marrafa, T; Thurston, DE; Zinzalla, G | 1 |
| Aaron, JJ; Brochon, JC; Kozmík, V; Lô, C; Na, L; Svoboda, J | 1 |
| Duan, Z; Liu, X; Ranjit, S | 1 |
| Beaver, Y; Borchardt, AJ; Cayanan, CS; Clark, AF; Cook, TG; Cramp, J; Davis, RL; Gardiner, EM; Hellberg, MR; Kahraman, M; McLaughlin, MA; Noble, SA; Prins, TJ; Shiau, AK | 1 |
| Bhargava, SK; Kantam, ML; Kennady, PK; Likhar, PR; Racharlawar, SS; Sridhar, B; Subhas, MS | 1 |
| Andrés, RM; Aquino, M; Bruno, I; De Simone, R; Guerrero, MD; Paya, M; Riccio, R; Terencio, MC | 1 |
| Babic, S; Calvin, W; Cui, J; Luedtke, RR; Mach, RH; Taylor, M; Vangveravong, S; Xu, J | 1 |
| Arrazola, A; Encío, I; Gil, MJ; Martinez-Merino, V; Sagardoy, AA; Villar, R; Viñas, MJ | 1 |
| Elder, JE; McRee, DE; Olson, AJ; Perryman, AL; Rosenfeld, R; Soutter, HH; Stout, CD; Zhang, Q | 1 |
| Aggarwal, S; Bhardwaj, TR; Kumar, M; Thareja, S | 1 |
| Allison, BD; Boggs, JD; Carruthers, NI; Everson, AM; Grice, CA; Lee-Dutra, A; Letavic, MA; Lord, B; Lovenberg, TW; McClure, KJ; Morton, KL; Nepomuceno, D; Santillan, A | 1 |
| Braun, M; Fischer, A; Frank, W; Grittner, D; Lachenicht, S; Lemoine, H; Rood, A; Schmidt, C; Winkler, M; Wrobel, T | 1 |
| Asmadi, A; Kendrick, J; Leusen, FJ | 1 |
| Guilarte, V; Hernando, E; Sanjuán, AM; Sanz, R | 1 |
| HANSCH, C; LINDWALL, HG | 1 |
| Berthelette, C; Chateauneuf, A; Li, L; Ouellet, M; Sturino, CF; Wang, Z | 1 |
| Kim, E; Seo, S; Yun, C | 1 |
| Denis, D; Li, L; Mathieu, MC; Therien, AG; Wang, Z | 1 |
| Kumatani, A; Liu, C; Lu, X; Minari, T; Takimiya, K; Tsukagoshi, K | 1 |
| Castedo, L; Fox, GC; González-Bello, C; Hawkins, AR; Lamb, H; Lapthorn, AJ; Llamas-Saiz, AL; Otero, JM; Paz, S; Tizón, L; van Raaij, MJ | 1 |
| Pawar, MG; Srivatsan, SG | 1 |
| Fukumoto, S; Kawai, T; Nakashima, T | 1 |
| Hao, M; Li, Y; Yang, W; Zhang, SW | 1 |
| Aisa, B; Aldana, I; Battaglia, G; Berrade, L; Galiano, S; Guccione, S; Levy, FO; Molinaro, G; Moltzau, LR; Monge, A; Nicoletti, F; Perez-Silanes, S; Ramirez, MJ | 1 |
| Arsenyan, P; Belyakov, S; Domracheva, I; Jaschenko, E; Paegle, E; Popelis, J; Shestakova, I | 1 |
| Duan, Z; Huang, H; Li, J; Mei, Y; Zhao, W | 1 |
| Fernández-Rodríguez, MA; García-García, P; Guilarte, V; Hernando, E; Sanz, R | 1 |
| Carfagna, C; Gabriele, B; Lupinacci, E; Mancuso, R; Salerno, G; Veltri, L | 1 |
| Banerjee, T; Dwivedi, V; Kapoor, N; Sharma, SK; Surolia, A; Surolia, N | 1 |
| Banerjee, T; Kapoor, N; Surolia, A; Surolia, N | 1 |
| Allen, CC; Boyd, DR; Coulombel, LA; Hamilton, JT; Haughey, SA; McMurray, B; McRoberts, WC; Nikodinovic-Runic, J; O'Connor, KE; O'Ferrall, RA; Sharma, ND | 1 |
| Bolton, JL; Chandrasena, ER; Choi, J; Edirisinghe, PD; Hemachandra, LP; Kastrati, I; Thatcher, GR; Wang, YT | 1 |
| Andersson, JT; Nocun, M | 1 |
| Hasan, Z; Jeon, J; Jhung, SH | 1 |
| Robbat, A; Wilton, N; Zeigler, C | 1 |
| Berti, F; Chiummiento, L; Funicello, M; Lupattelli, P; Marino-Merlo, F; Tramutola, F | 1 |
| Andersson, JT; Fathalla, EM; Hegazi, AH; Panda, SK; Schrader, W | 1 |
| Fung, MK; Lee, CS; Ou, XM; Ye, J; Zhang, XH; Zheng, CJ | 1 |
| Dannhardt, G; Geffken, D; Hansen, FK; Khankischpur, M; Mesaros, R; Tolaymat, I | 1 |
| Chou, SC; Jang, YJ; Lee, CJ; Lee, YT; Lin, W; Syu, SE | 1 |
| Allen, CC; Boyd, DR; Brannigan, IN; Evans, TA; Haughey, SA; Malone, JF; McIntyre, PB; McMurray, BT; Sharma, ND; Stevenson, PJ | 1 |
| Jhung, SH; Khan, NA | 2 |
| Sarker, MI; Shahrin, T; Steinmetz, MG; Timerghazin, QK | 1 |
| Hari, DP; Hering, T; König, B | 1 |
| Abdayem, R; Barret, R; Colomb, E; Dubois, J; Guillaume, J; Haftek, M; Lomberget, T; Nachtergaele, L; Nguyen, TT; Thoret, S; Tran, NC | 1 |
| Funaki, K; Oi, S; Sato, T | 1 |
| Coates, L; Ng, JD; Ostermann, A; Schrader, TE; Standaert, RF; Tomanicek, SJ; Weiss, KL | 1 |
| Churruca, F; Domínguez, E; Hernández, S; Perea, M; SanMartin, R | 1 |
| Prasad, DJ; Sekar, G | 1 |
| Davies, L; Marais, R; Ménard, D; Niculescu-Duvaz, D; Niculescu-Duvaz, I; Pons, JF; Springer, CJ; Suijkerbuijk, BM; Whittaker, S; Zambon, A | 1 |
| Meng, JB; Pang, ML; Tan, TF; Wu, BP | 1 |
| Ahmed, I; Hasan, Z; Jhung, SH; Khan, NA | 1 |
| Collins, KD; Glorius, F; Tang, DT | 1 |
| Bartoli, S; Berettoni, M; Bigioni, M; Binaschi, M; Cipollone, A; Ettorre, A; Fattori, D; Fincham, CI; Maggi, CA; Marastoni, E; Mauro, S; Nardelli, F; Paris, M; Parlani, M; Porcelloni, M | 1 |
| Anxionnat, B; Cossy, J; Gomez Pardo, D; Ricci, G; Rossen, K | 1 |
| Baska, F; Boon, TC; Greff, Z; Horváth, Z; Kéri, G; Németh, G; Orfi, L; Szántai-Kis, C; Szokol, B; Zsákai, L | 1 |
| Chen, SA; Cheng, YS; Jhuo, HJ; Liao, SH | 1 |
| Li, Y; Yu, H; Zhang, M | 1 |
| Wu, B; Yoshikai, N | 1 |
| Inamoto, K | 1 |
| Bonano, VI; Dodge, JA; Jones, SA; Miguel, DC; Uliana, SR; Yokoyama-Yasunaka, JK | 1 |
| Bandholtz, S; Goebel, M; Gust, R; Herbst, L; Kintscher, U | 1 |
| Buchet, R; Chang, L; Debray, J; Le Duy, D; Lemaire, M; Magne, D; Marquès, S; Mebarek, S; Pellet-Rostaing, S; Popowycz, F | 1 |
| Aleksić, M; Bertoša, B; David-Cordonnier, MH; Depauw, S; Karminski-Zamola, G; Kralj, M; Martin-Kleiner, I; Nhili, R; Tomić, S | 1 |
| Ji, K; Li, G; Lian, K; Ma, T; Tian, H; Wang, W; Zhang, Y | 1 |
| Al-Zahrani, I; Basheer, C; Htun, T | 1 |
| Brannigan, JA; Holder, AA; Leatherbarrow, RJ; Meister, S; Rackham, MD; Rangachari, K; Tate, EW; Wilkinson, AJ | 1 |
| Inouchi, T; Kawai, T; Nakashima, T | 1 |
| Che, LM; Gui, SZ; Huang, YB; Huang, ZL; Tu, S; Xie, YQ; Ye, LY | 1 |
| Fan, C; Sheng, J; Wu, J | 1 |
| Chen, PQ; Chen, YC; Xiao, YC; Yue, CZ | 1 |
| Chuang, DT; Chuang, JL; Dork, K; Gui, WJ; Hutson, SM; Lee, BH; Morlock, LK; Qi, X; Skvora, KJ; Strom, SC; Tambar, UK; Tso, SC; Wallace, AL; Williams, NS; Wu, CY; Wynn, RM | 1 |
| Ma, F; Qu, Y; Shi, S; Zhou, J | 1 |
| Al-Abduly, A; Sharma, VK | 1 |
| Gharpure, SJ; Prasath, V | 1 |
| Gherezghiher, T; Jordan, VC; Maximov, PY; Michalsen, BT; Molloy, ME; Patel, H; Thatcher, GR; Tonetti, DA; White, BE; Xiong, R; Zhao, H | 1 |
| Khedkar, S; Shanker, R | 1 |
| Chen, C; Luo, Y; Pan, X; Wu, J; Yao, L | 1 |
| Jiang, H; Liu, B; Peng, H; Yin, B; Zhang, X; Zhou, W | 1 |
| Gerchikov, AY; Khayrullina, VR; Lagunin, AA; Zarudii, FS | 1 |
| Poole, CF | 1 |
| Liu, J; Liu, X; Ming, W; Wang, L; Wang, M | 1 |
| Guo, HF; Jin, J; Ju, DH; Li, ZR; Liu, MJ; Liu, ZY; Xue, ST | 1 |
| Chang, Y; Jiang, W; Li, H; Xia, J; Yin, S; Zhang, M; Zhu, W | 1 |
| Gong, YD; Kim, YS; Kwak, SH | 1 |
| Benoy, V; Bougarne, N; D'hooghe, M; De Bosscher, K; De Vreese, R; Desmet, T; Haeck, W; Van Den Bosch, L; Van Steen, N; Verhaeghe, T | 1 |
| Bagley, MC; Dwyer, JE; Molina, MD; Rand, AW; Rand, HL; Tomkinson, NC | 1 |
| Crooks, PA; Penthala, NR; Thakkar, S | 1 |
| Hanna, LE; Jarvo, ER; Tollefson, EJ | 1 |
| Bouhours, P; Ganem-Elbaz, C; Jolivalt, C; Lemaire, M; Liger, F; Paris, JM; Pellet-Rostaing, S; Popowycz, F | 1 |
| Chen, W; Dong, G; He, S; Liu, N; Miao, C; Sheng, C; Wang, X; Xu, T; Zhang, W | 1 |
| Abdallah, AE; Helal, MH; Mohareb, RM; Shaloof, SM | 1 |
| Bilodeau, MT; Chang, RK; Drolet, RE; Greshock, TJ; Kern, JT; Kim, B; Lai, MT; McCauley, JA; Rada, VL; Rajapakse, HA; Renger, JJ; Sanchez, RI; Sanders, JM; Su, H; Sur, SM; Tiscia, HE | 1 |
| Aleksić, M; Ilić, N; Karminski-Zamola, G; Pavelić, SK; Racané, L; Sedić, M | 1 |
| Allarà, M; Di Marzo, V; Escobar, R; Faúndez, M; Iturriaga-Vásquez, P; Mella-Raipán, J; Palmieri, V; Pessoa-Mahana, CD; Pessoa-Mahana, H; Romero-Parra, J; Torres, MJ | 1 |
| Dürüst, Y; Karakuş, H | 1 |
| Guo, J; Kong, L; Li, S; Ma, T; Yang, Y; Yu, W; Zhang, W | 1 |
| Blum, SA; Davis, AJ; Faizi, DJ; Meany, FB | 1 |
| Oberoi, AS; Philip, L | 1 |
| Gray, NS; Hur, W; Rosen, H | 1 |
| Liu, LH; Yan, XP; Yang, CX | 1 |
| Gutgesell, LM; Karumudi, B; Lee, S; Lu, Y; Thatcher, GR; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J | 1 |
| Chung, H; David Pessoa-Mahana, C; Di Marzo, V; Faúndez, M; Lagos, CF; Lorca, M; Mella, J; Morales-Verdejo, C; Romero-Parra, J; Tapia, RA | 1 |
| Fatahi, A; Sadeghi, S | 1 |
| Chaturbhuj, GU; Goyal, SN; Indalkar, KS; Khatri, CK; Patil, CR | 1 |
| El-Hawash, SA; El-Messmary, H; El-Miligy, MM; Hazzaa, AA; Nassra, RA | 1 |
| El-Hawash, SAM; El-Messmary, H; El-Miligy, MMM; Hazzaa, AA; Nassra, RA | 1 |
| Ha, JD; Han, SB; Jung, YK; Jung, YS; Kim, C; Kim, J; Lee, CK; Lee, JY; Neyts, J; Scheers, E; Shin, JS | 1 |
| Balappa Somappa, S; Budagumpi, S; Chand, K; Keri, RS; Nagaraja, BM; Patil, SA | 1 |
| Shuai, Z; Wang, Z; Wei, Z; Zhu, L | 1 |
| Grassi, G; Maes, L; Micale, N; Piperno, A; Rescifina, A; Scala, A; Schirmeister, T | 1 |
| Abbas, NS; Ibrahim, RA; Mohareb, RM | 1 |
| Arnoult, E; Huang, H; Lim, HK; Liu, J; Martin, T; Meegalla, SK; Otieno, M; Paul Lee, S; Player, MR; Pocai, A; Rady, B; Silva, J; Towers, M; Winters, MP; Xu, F; Zhao, S | 1 |
| Akhtar, K; Akhtar, N; Ghauri, MA | 1 |
| Kimura, H; Kuno, H; Kunugi, A; Sogabe, S; Tajima, Y | 1 |
| Andjelković, B; Bavari, S; Cazares, LH; Duplantier, AJ; Kiris, E; Konstantinović, J; Kota, KP; Kugelman-Tonos, J; Šolaja, BA; Terzić Jovanović, N; Verbić, TŽ; Videnović, M | 1 |
| Balova, IA; Bräse, S; Chislov, MV; Danilkina, NA; Govdi, AI; Khlebnikov, AF; Lyapunova, AG; Rumyantsev, AM; Sambuk, EV; Starova, GL | 1 |
| Cherkasov, A; Dalal, K; Lallous, N; Munuganti, RSN; Rennie, PS; Sharma, A; Singh, K; Yamazaki, T; Yoon, JS | 1 |
| Bryant, D; Cater, L; Chen, H; Hallani, RK; Lopatin, S; McCulloch, I; Neophytou, M; Yue, W | 1 |
| Marimuthu, P; Singaravelu, K | 1 |
| Bánhegyi, P; Boros, S; Brauswetter, D; Czudor, Z; Gyulavári, P; Illyés, E; Krekó, M; Markó, P; Őrfi, L; Szabadkai, I; Szántai-Kis, C; Szokol, B; Varga, A | 1 |
| Cordova, J; Dimirjian, CA; Fettinger, JC; Hodur, BM; Nickerson, LA; Penrod, CN; Shaw, JT; Souza, LW; Squitieri, RA | 1 |
| Abe, K; Asakura, T; Kasahara, Y; Kojima, H; Matsuda, R; Misaka, T; Mori, N; Narukawa, M; Okabe, T; Sakurai, T; Watanabe, H; Yasuoka, A | 1 |
| Chen, B; Chen, H; Dong, W; Li, Z; Wang, X; Xiang, Y; Zhang, X | 1 |
| Al-Zaydi, KM; Arab, ST; Mousally, SMM; Petrier, C; Refat, MS | 1 |
| Hayashi, Y; Hiramatsu, K; Kawamoto, Y; Oyama, Y; Tomino, M | 1 |
| Doebelin, C; Kamenecka, TM; Kuryatov, A; Leffler, A; Lindstrom, J; Norleans, J; Wang, J | 1 |
| Afridi, S; Amjad, ST; Anbar, HS; El-Gamal, MI; El-Gamal, R; Iqbal, J; Shafique, Z; Zaib, S; Zaraei, SO | 1 |
| Barbarossa, A; Caruso, A; Ceramella, J; Dallemagne, P; El-Kashef, H; Grande, F; Iacopetta, D; Occhiuzzi, MA; Rault, S; Rizzuti, B; Saturnino, C; Sinicropi, MS | 1 |
| Alunda, JM; Baptista, C; Bifeld, E; Borsari, C; Clos, J; Cordeiro-da-Silva, A; Corral, MJ; Costantino, L; Costi, MP; Eick, J; Ellinger, B; Ferrari, S; Franco, CH; Gul, S; Jiménez-Antón, MD; Kuzikov, M; Linciano, P; Luciani, R; Moraes, CB; Olías-Molero, AI; Ponterini, G; Reinshagen, J; Santarem, N; Severi, L; Tait, A; Tejera Nevado, P; Torrado, JJ; Witt, G; Wolf, M; Zander-Dinse, D | 1 |
| Bekier, A; Cytarska, J; Dzitko, K; Płaziński, W; Rosada, B; Sikora, A; Zavyalova, O; Łączkowski, KZ | 1 |
| Gao, Y; Li, X; Sun, Y; Xu, F; Zhang, Q; Zheng, S; Zuo, C | 1 |
| Chen, H; Dubrovyskyii, O; Dye, K; Gordon-Blake, J; Gutgesell, LM; He, D; Hollas, M; Huang, F; Lasek, AW; Lee, S; Li, Y; Lu, Y; Rosales, CI; Shen, Z; Thatcher, GRJ; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J | 1 |
| Agoni, C; Munsamy, G; Ramharack, P; Soliman, MES | 1 |
| Assali, EA; Baranovski, BM; Barr, H; Cerqueira, FM; Gazit, R; Kozer, N; Las, G; Lewis, EC; Petcherski, A; Roth, Y; Shirihai, OS; Wolf, D | 1 |
| Li, Q; Liu, F; Ren, Y; Zhang, C | 1 |
| Baumann, MH; Brandt, SD; Carlino, L; Dowling, G; Dreiseitel, W; Halberstadt, AL; Kavanagh, PV; Sitte, HH; Westphal, F | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Barakat, A; Boraei, ATA; Eltamany, EH; Gad, EM; Hammad, MSAG; Nafie, MS | 1 |
| Kang, N; Liu, Y; Ullah, S; Wang, Z; Zhang, J; Zhao, Y; Zhou, H | 1 |
| Bräuer, J; Dao-Huy, T; Dirsch, VM; Latkolik, S; Mihovilovic, MD; Pfeil, A; Schnürch, M; Stuppner, H | 1 |
| Al-Rashida, M; Anbar, HS; El-Gamal, MI; El-Gamal, R; Iqbal, J; Pelletier, J; Sévigny, J; Ullah, S; Zaib, S; Zaraei, SO | 1 |
| Banerjee, T; Ghosh, A | 1 |
| Domini, CE; Schiel, MA; Silbestri, GF | 1 |
| Cai, J; Du, J; Fang, Z; Guo, K; He, W; Liu, C; Wang, X; Yang, Z; Zhang, D | 1 |
| Abadi, AH; Abdel-Halim, M; Chen, PJ; El-Gamil, DS; ElHady, AK; Engel, M; Hwang, TL | 1 |
| Duan, X; Fang, H; Jiang, G; Liao, X; Liu, L; Tan, Y; Wang, J; Xiong, Y | 1 |
| Bai, C; Luo, G; Ren, S; Wu, S; Xiang, H; Zhu, M | 2 |
| Kavak, E; Kivrak, A; Ozok, O | 1 |
| Goto, M; Hamel, E; Hirazawa, S; Miura, Y; Nakagawa-Goto, K; Nakayoshi, T; Oda, A; Saito, Y; Taniguchi, Y; Tsurimoto, H; Yamashita, K | 1 |
| Jiao, X; Li, Y; Liu, K; Tang, B; Wang, X; Xie, X; Zhang, J; Zhang, R | 1 |
| Hao, GZ; Jiang, CS; Li, Y; Liu, SK; Xie, HX; Zhang, J; Zhang, JH; Zheng, H; Zhu, KK | 1 |
| Tang, BZ; Wang, D; Wang, L; Xie, W; Yan, D; Zhang, J | 1 |
| Hamdi, Z; Mohseni, E; Rahmani, A | 1 |
| Goto, M; Hirazawa, S; Nakagawa-Goto, K; Sagano, M; Saito, Y | 1 |
| Cai, J; Chen, X; Ji, M; Wang, Y | 1 |
| Agina, EV; Anisimov, DS; Borshchev, OV; Krylov, VB; Nifantiev, NE; Poimanova, EY; Polinskaya, MS; Ponomarenko, SA; Shaposhnik, PA; Skorotetcky, MS; Trul, AA; Vinnitskiy, DZ; Zavyalova, EG | 1 |
| Azevedo, H; Couñago, RM; Cunha, MR; da Silva Santiago, A; Damião, MCFCB; Fala, AM; Ferreira, MA; Godoi, PH; Guimarães, CRW; Ishikawa, EE; Mascarello, A; Ramos, PZ; Segretti, ND; Serafim, RAM; Takarada, JE; Teodoro, BVM | 1 |
| Babu, SA; John, J; Krishnan R, A; Ravi, NP; Thulasi, S | 1 |
| Betz, K; Diederichs, K; Ghosh, P; Kropp, HM; Ludmann, S; Marx, A; Srivatsan, SG | 1 |
| Deng, Q; Gu, J; Meng, X; Zhang, H; Zhang, Y | 1 |
| Ding, C; Geng, M; Li, X; Liu, Z; Ma, J; Shen, A; Song, Z; Wang, X; Xiao, R; Xie, Z; Zhang, A; Zhang, Y | 1 |
| Ma, P; Ren, P; Song, D; Xu, L; Zhang, H; Zhang, S; Zhao, L | 1 |
| Lee, J; Park, CM; Yu, E | 1 |
| Chen, D; Guo, H; Liu, W; Mu, N; Wang, S; Wang, W; Yin, Y; Zhang, E | 1 |
| Avecilla, F; de Almeida, RFM; Dömötör, O; Enyedy, ÉA; Lenis-Rojas, OA; Marques, F; Matos, CP; Spengler, G; Teixeira, RG; Tomaz, AI | 1 |
| Abbasi, S; Bahiraei, A; Tavakkoli Yaraki, M | 1 |
9 review(s) available for benzothiophene and thiophenes
| Article | Year |
|---|---|
[HTLV-I--associated myelopathy/tropical spastic paraparesis (HAM/TSP)].
Topics: Antigen-Presenting Cells; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dendritic Cells; Human T-lymphotropic virus 1; Humans; Lymphocyte Activation; Paraparesis, Tropical Spastic; Thiophenes | 2000 |
Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs).
Topics: Breast Neoplasms; Drug Design; Estrogen Receptor alpha; Female; Humans; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Stilbenes; Structure-Activity Relationship; Tamoxifen; Thiophenes; Toremifene | 2007 |
GABA A/Bz receptor subtypes as targets for selective drugs.
Topics: Benzodiazepines; Carbolines; Flavones; Indoles; Pyrazoles; Pyridazines; Pyridones; Receptors, GABA-A; Thiophenes; Triazoles | 2007 |
Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.
Topics: Acetophenones; Amino Acid Sequence; Animals; Benzoates; Benzofurans; Biphenyl Compounds; Blood Glucose; Catalytic Domain; Catechols; Chromones; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fluorides; Humans; Insulin; Insulin Resistance; Insulin Secretion; Janus Kinase 2; Models, Molecular; Naphthoquinones; Peptidomimetics; Phosphates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyridazines; Receptor, Insulin; Signal Transduction; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Thiophenes; Vanadium Compounds | 2012 |
Synthesis of heterocyclic compounds through palladium-catalyzed C-H cyclization processes.
Topics: Benzothiazoles; Carbon; Catalysis; Cyclization; Heterocyclic Compounds; Hydrogen; Indazoles; Indoles; Palladium; Quinolones; Thiophenes | 2013 |
Ionization-based detectors for gas chromatography.
Topics: Chromatography, Gas; Flame Ionization; Gasoline; Helium; Hydrogen; Thiophenes | 2015 |
An overview of benzo[b]thiophene-based medicinal chemistry.
Topics: Animals; Chemistry, Pharmaceutical; Disease; Humans; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2017 |
A-π-D-π-A Electron-Donating Small Molecules for Solution-Processed Organic Solar Cells: A Review.
Topics: Electric Power Supplies; Electrons; Fullerenes; Polymers; Porphyrins; Quantum Theory; Solar Energy; Solutions; Thiophenes | 2017 |
Mutasynthesis Generates Antibacterial Benzothiophenic-Containing Nosiheptide Analogues.
Topics: Anti-Bacterial Agents; Thiazoles; Thiophenes | 2022 |
1 trial(s) available for benzothiophene and thiophenes
| Article | Year |
|---|---|
Effect of raloxifene on serum triglycerides in postmenopausal women: influence of predisposing factors for hypertriglyceridemia.
Topics: Adult; Aged; Aged, 80 and over; Causality; Female; Humans; Hypertriglyceridemia; Middle Aged; Osteoporosis; Pancreatitis; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Triglycerides | 2001 |
275 other study(ies) available for benzothiophene and thiophenes
| Article | Year |
|---|---|
Biotransformation of benzothiophene by isopropylbenzene-degrading bacteria.
Topics: Aldehyde Oxidoreductases; Benzene Derivatives; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Hydro-Lyases; Pseudomonas putida; Thiophenes | 1994 |
Effects of benzothiophene on male rats following short-term oral exposure.
Topics: Administration, Oral; Animal Feed; Animals; Ascorbic Acid; Dose-Response Relationship, Drug; Eating; Environmental Pollutants; Kidney; Liver; Male; Microsomes, Liver; Organ Size; Rats; Rats, Sprague-Dawley; Thiophenes; Thymus Gland; Weight Gain | 1997 |
Casein kinase II is a selective target of HIV-1 transcriptional inhibitors.
Topics: Anti-HIV Agents; Carrier Proteins; Casein Kinase II; Catechin; Cell Line; Chamomile; Chromatography, Affinity; Flavonoids; Hesperidin; HIV-1; HL-60 Cells; Humans; Kinetics; NF-kappa B; Oils, Volatile; Plants, Medicinal; Protein Serine-Threonine Kinases; Recombinant Proteins; Thiophenes; Transcription, Genetic; Virus Integration; Virus Replication | 1997 |
Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Humans; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiophenes; Thrombin | 1997 |
Subchronic toxicity of benzothiophene on rats following dietary exposure.
Topics: Animals; Aspartate Aminotransferases; Behavior, Animal; Bilirubin; Diet; Dose-Response Relationship, Drug; Female; Hematologic Tests; Kidney Medulla; Liver; Male; Nervous System Diseases; No-Observed-Adverse-Effect Level; Rats; Rats, Sprague-Dawley; Sex Factors; Thiophenes; Time Factors | 1998 |
Isolation of a unique benzothiophene-desulphurizing bacterium, Gordona sp. strain 213E (NCIMB 40816), and characterization of the desulphurization pathway.
Topics: Actinomycetales; Culture Media; Fossil Fuels; Fructose; Rhodococcus; Soil Microbiology; Species Specificity; Sulfur; Thiophenes | 1998 |
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.
Topics: Binding Sites; Crystallography, X-Ray; Models, Chemical; Models, Molecular; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiophenes; Thrombin | 1998 |
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain.
Topics: Antithrombins; Binding Sites; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Thiophenes | 1999 |
Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: optimization of the C-2 side chain.
Topics: In Vitro Techniques; Receptors, Neuropeptide Y; Recombinant Proteins; Structure-Activity Relationship; Thiophenes | 1999 |
Dibasic benzo[B]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[B]thiophenes.
Topics: Structure-Activity Relationship; Thiophenes; Thrombin | 1999 |
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.
Topics: Animals; Anticoagulants; Binding Sites; Crystallography, X-Ray; Disease Models, Animal; Humans; Models, Molecular; Rats; Structure-Activity Relationship; Thiophenes; Thrombin; Thrombosis | 1999 |
Gordonia desulfuricans sp. nov., a benzothiophene-desulphurizing actinomycete.
Topics: Actinomycetales; Bacterial Typing Techniques; Base Composition; DNA, Bacterial; DNA, Ribosomal; Genes, rRNA; Molecular Sequence Data; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Thiophenes | 1999 |
Keratinocyte-melanocyte co-cultures and pigmented reconstructed human epidermis: models to study modulation of melanogenesis.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Arbutin; Asian People; Benzofurans; Black People; Cells, Cultured; Coculture Techniques; Culture Media; Epidermal Cells; Ethnicity; Humans; Hydroquinones; Hydroxybenzoates; Indoles; Keratinocytes; Melanins; Melanocytes; Mice; Phenotype; Pyrones; Skin Pigmentation; Skin, Artificial; Theophylline; Thiophenes; Ultraviolet Rays; White People | 1999 |
The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
Topics: Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Structure-Activity Relationship; Thiophenes; Thrombin | 2000 |
Alkylated benzothiophene desulfurization by Rhodococcus sp. strain T09.
Topics: Alkylation; Molecular Structure; Rhodococcus; Sulfur Compounds; Thiophenes | 2000 |
Desulfurization of alkylated forms of both dibenzothiophene and benzothiophene by a single bacterial strain.
Topics: Alkylation; Biodegradation, Environmental; Gas Chromatography-Mass Spectrometry; Rhodococcus; Soil Microbiology; Thiophenes | 2000 |
Demonstration of the carbon-sulfur bond targeted desulfurization of benzothiophene by thermophilic Paenibacillus sp. strain A11-2 capable of desulfurizing dibenzothiophene.
Topics: Bacillus; Biodegradation, Environmental; Carbon; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Sulfur; Thiophenes | 2000 |
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: further focus on the contracted C4'-side chain analogues.
Topics: Antithrombins; Structure-Activity Relationship; Thiophenes | 2000 |
A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents.
Topics: Antineoplastic Agents; Catalysis; Colchicine; Humans; Palladium; Protein Binding; Structure-Activity Relationship; Thiophenes; Tubulin; Tumor Cells, Cultured | 2001 |
Electron transfer compatible molecular design of benzothiophene-acetophenone bichromophores: a theoretical approach.
Topics: Chemical Phenomena; Chemistry, Physical; Electrons; Models, Chemical; Molecular Structure; omega-Chloroacetophenone; Photosensitizing Agents; Spectrophotometry; Thiophenes | 2001 |
Desulfurization of benzothiophene by the Gram-negative bacterium, Sinorhizobium sp. KT55.
Topics: Amino Acids; Biodegradation, Environmental; Culture Media; Dimethyl Sulfoxide; Gas Chromatography-Mass Spectrometry; Sinorhizobium; Sulfur; Thiophenes | 2001 |
Microbial desulfurization of alkylated dibenzothiophene and alkylated benzothiophene by recombinant Rhodococcus sp. strain T09.
Topics: Alkylation; Cloning, Molecular; Rhodococcus; Sulfur; Thiophenes | 2001 |
Anaerobic cometabolic conversion of benzothiophene by a sulfate-reducing enrichment culture and in a tar-oil-contaminated aquifer.
Topics: Anaerobiosis; Culture Media; Fresh Water; Oxidation-Reduction; Sulfates; Sulfur-Reducing Bacteria; Tars; Thiophenes; Water Pollution | 2001 |
Benzo[b]thiophene desulfurization by Gordonia rubropertinctus strain T08.
Topics: Culture Media; Gas Chromatography-Mass Spectrometry; Gram-Positive Bacteria; Sulfur; Thiophenes | 2001 |
New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells.
Topics: Antineoplastic Agents; Cell Membrane; Culture Media; Drug Screening Assays, Antitumor; Humans; Kinetics; Leukemia; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Sulfonylurea Compounds; Thiophenes; Tumor Cells, Cultured | 2001 |
Synthesis and studies on spectroscopic as well as electron donating properties of the two alkoxy benzo[b]thiophenes.
Topics: Acetonitriles; Electrochemistry; Fluorescence Polarization; Kinetics; Spectrum Analysis; Temperature; Thiophenes | 2001 |
Chemostat approach for the directed evolution of biodesulfurization gain-of-function mutants.
Topics: Base Sequence; Culture Media; Evolution, Molecular; Molecular Sequence Data; Mutation; Oxidoreductases; Oxygenases; Rhodococcus; Substrate Specificity; Sulfides; Sulfur Compounds; Thiophenes | 2002 |
Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.
Topics: Amino Acid Motifs; Binding Sites; Central Nervous System Diseases; Crystallography, X-Ray; Estrogen Receptor beta; HeLa Cells; Humans; Ligands; Models, Chemical; Models, Molecular; Protein Structure, Tertiary; Receptors, Estrogen; Thiophenes; Tumor Cells, Cultured | 2002 |
Aerobic co-metabolism of sulfur, nitrogen and oxygen heterocycles by three marine bacterial consortia.
Topics: Aerobiosis; Benzofurans; Biodegradation, Environmental; Carbazoles; Ecosystem; Gas Chromatography-Mass Spectrometry; Gram-Negative Bacteria; Heterocyclic Compounds; Newfoundland and Labrador; Nitrogen; Oxygen; Seawater; Spectroscopy, Fourier Transform Infrared; Sulfur; Thiophenes | 2002 |
Isolation and characterization of thermophilic benzothiophene-degrading Mycobacterium sp.
Topics: Biodegradation, Environmental; Gram-Positive Bacteria; Kinetics; Mycobacterium; Petroleum; Phylogeny; RNA, Ribosomal, 16S; Sulfuric Acids; Thailand; Thiophenes | 2002 |
Biodesulfurization of benzothiophene and dibenzothiophene by a newly isolated Rhodococcus strain.
Topics: Biodegradation, Environmental; Rhodococcus; Sulfur; Thiophenes | 2002 |
Biodesulfurization of naphthothiophene and benzothiophene through selective cleavage of carbon-sulfur bonds by Rhodococcus sp. strain WU-K2R.
Topics: Carbon; Culture Media; Gas Chromatography-Mass Spectrometry; Rhodococcus; Sulfur; Thiophenes | 2002 |
Analysis of aromatic sulfur compounds in gas oils using GC with sulfur chemiluminescence detection and high-resolution MS.
Topics: Gas Chromatography-Mass Spectrometry; Luminescent Measurements; Petroleum; Polycyclic Aromatic Hydrocarbons; Sensitivity and Specificity; Sulfur Compounds; Thiophenes | 2002 |
Recombinant Rhodococcus sp. strain T09 can desulfurize DBT in the presence of inorganic sulfate.
Topics: Cloning, Molecular; Culture Media; Cysteine; DNA, Recombinant; Methionine; Models, Genetic; Operon; Promoter Regions, Genetic; Rhodococcus; RNA, Ribosomal, 16S; Sequence Alignment; Sequence Analysis, DNA; Sulfates; Thiophenes | 2002 |
Purification and characterization of the monooxygenase catalyzing sulfur-atom specific oxidation of dibenzothiophene and benzothiophene from the thermophilic bacterium Paenibacillus sp. strain A11-2.
Topics: Alkylation; Bacterial Proteins; Enzyme Inhibitors; Gram-Positive Endospore-Forming Rods; Hydrogen-Ion Concentration; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Substrate Specificity; Sulfur; Temperature; Thiophenes | 2002 |
Crystal structures of two potent nonamidine inhibitors bound to factor Xa.
Topics: Amidines; Anticoagulants; Crystallization; Crystallography, X-Ray; Factor Xa Inhibitors; Humans; Molecular Conformation; ortho-Aminobenzoates; Oxazoles; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiophenes | 2002 |
New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation.
Topics: Blood Coagulation; Blood Coagulation Tests; Fibrinolytic Agents; Humans; Inhibitory Concentration 50; Plasminogen Activator Inhibitor 1; Protein Binding; Structure-Activity Relationship; Thiophenes; Tissue Plasminogen Activator | 2003 |
Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa.
Topics: Anticoagulants; Binding Sites; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Humans; ortho-Aminobenzoates; Phospholipids; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiophenes | 2003 |
The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs.
Topics: Base Pairing; Benzofurans; Circular Dichroism; DNA; Hydrogen Bonding; Indoles; Kinetics; Nucleotides; Thiophenes; Triazoles | 2003 |
New benzo(b)thiophenesulphonamide 1,1-dioxide derivatives induce a reactive oxygen species-mediated process of apoptosis in tumour cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspase 8; Caspase 9; Caspases; Humans; Membrane Proteins; Mitochondria; Oligopeptides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfonamides; Thiophenes; Tumor Cells, Cultured | 2003 |
Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors.
Topics: Arylamine N-Acetyltransferase; Drug Design; Enzyme Inhibitors; Humans; Molecular Structure; Quantitative Structure-Activity Relationship; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Thiophenes | 2003 |
The synthesis of some substituted thianaphthene-2-carboxamides and their antifungal properties.
Topics: Antifungal Agents; Fungicides, Industrial; Thiophenes | 1958 |
BENZO(B)THIOPHENE DERIVATIVES. IV. THE PREPARATION AND PHARMACOLOGICAL ACTIVITY OF COMPOUNDS RELATED TO SEROTONIN AND GRAMINE.
Topics: Alkaloids; Blood Pressure; Cats; Chemistry, Pharmaceutical; Female; Guinea Pigs; Humans; Ileum; Indole Alkaloids; Jejunum; Mice; Muscle Contraction; Muscle, Smooth; Muscles; Pharmacology; Rats; Research; Serotonin; Stomach; Thiophenes; Toxicology; Uterus; Vasomotor System | 1963 |
[N-ALKYL-ALKANOLAMINES OF THE THIONAPHTHENE SERIES].
Topics: Chemistry, Pharmaceutical; Heterocyclic Compounds; Pharmacy; Research; Sympathomimetics; Thiophenes | 1964 |
BENZO(B)THIOPHENE DERIVATIVES. V. MANNICH BASES WITH ANTIMICROBIAL ACTIVITY.
Topics: Anti-Infective Agents; Chemistry, Pharmaceutical; Escherichia coli; Mannich Bases; Pharmacology; Research; Saccharomyces; Staphylococcus; Thiophenes | 1965 |
Substrate preferences in biodesulfurization of diesel range fuels by Rhodococcus sp. strain ECRD-1.
Topics: Biodegradation, Environmental; Gas Chromatography-Mass Spectrometry; Gasoline; Rhodococcus; Substrate Specificity; Sulfur; Thiophenes | 2003 |
Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors.
Topics: Chymases; Drug Design; Humans; Protease Inhibitors; Serine Endopeptidases; Structure-Activity Relationship; Sulfonamides; Thiophenes | 2003 |
Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists.
Topics: Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Humans; Molecular Structure; Receptors, Neuropeptide Y; Structure-Activity Relationship; Thiophenes | 2004 |
Synthesis and cytotoxic activity of lipophilic sulphonamide derivatives of the benzo[b]thiophene 1,1-dioxide.
Topics: Antineoplastic Agents; Cell Division; Fibroblasts; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Structure-Activity Relationship; Sulfonamides; Thiophenes; Tumor Cells, Cultured | 2004 |
Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor.
Topics: Amides; Animals; Aorta; Binding, Competitive; Coronary Vessels; Dose-Response Relationship, Drug; Molecular Conformation; Molecular Structure; Piperazines; Rabbits; Saphenous Vein; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Thiophenes | 2004 |
Benzothiophene and naphthalene derived constrained SERMs.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Female; Humans; Ligands; Naphthalenes; Radioligand Assay; Rats; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes; Uterus | 2004 |
Synthesis and NMR spectroscopic studies of allylsulfanyl-N1-alkyl-N4-phenyl-1,4-phenylenediamines and their cyclization products, 2,3-dihydro-1-benzothiophenes and thiochromans.
Topics: Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Chromans; Crystallography, X-Ray; Cyclization; Magnetic Resonance Spectroscopy; Molecular Conformation; Phenylenediamines; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds; Thiophenes | 2004 |
Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study.
Topics: Amines; Anti-Infective Agents; Candida albicans; Drug Evaluation, Preclinical; Microbial Sensitivity Tests; Structure-Activity Relationship; Thiophenes | 2004 |
Monitoring toxicity of industrial wastewater and specific chemicals to a green alga, nitrifying bacteria and an aquatic bacterium.
Topics: Bacteria, Anaerobic; Biodegradation, Environmental; Bioreactors; Chlorophyta; Environmental Monitoring; Industrial Waste; Naphthalenes; Nitrites; Nitrogen; Risk Assessment; Sewage; Sulfones; Thiophenes; Waste Disposal, Fluid; Water Pollutants, Chemical | 2004 |
Thermophilic biodesulfurization of various heterocyclic sulfur compounds and crude straight-run light gas oil fraction by a newly isolated strain Mycobacterium phlei WU-0103.
Topics: Biodegradation, Environmental; Culture Media; Gasoline; Heterocyclic Compounds; Hot Temperature; Mycobacterium phlei; Petroleum; Sulfur Compounds; Thiophenes | 2005 |
Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.
Topics: Animals; Binding, Competitive; Bone Density; Drug Evaluation, Preclinical; Estrogen Receptor alpha; Female; Ligands; Mice; Molecular Structure; Piperazines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes; Uterus | 2005 |
In vitro metabolic fate of a novel structural class: evidence for the formation of a reactive intermediate on a benzothiophene moiety.
Topics: Animals; Biotransformation; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Glutathione; Hepatocytes; Mass Spectrometry; Microsomes, Liver; Oxides; Phenols; Rats; Thiophenes | 2005 |
Desulfurization of dibenzothiophene, benzothiophene, and other thiophene analogs by a newly isolated bacterium, Gordonia alkanivorans strain 1B.
Topics: Biodegradation, Environmental; Biotechnology; Cell Proliferation; Gordonia Bacterium; Kinetics; Species Specificity; Substrate Specificity; Sulfur; Sulfur Compounds; Thiophenes; Time Factors | 2005 |
Triplet-triplet energy transfer controlled by the donor-acceptor distance in rigidly held palladium-containing cofacial bisporphyrins.
Topics: Crystallography, X-Ray; Energy Transfer; Luminescent Measurements; Magnetic Resonance Spectroscopy; Metalloporphyrins; Molecular Structure; Palladium; Platinum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Thiophenes; Xanthenes; Zinc | 2005 |
Efficient access to 2-aryl-3-substituted benzo[b]thiophenes.
Topics: Cyclization; Molecular Structure; Oxidation-Reduction; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2005 |
Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzofurans; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Imidazoles; Mice; Molecular Structure; Netropsin; Pyrazoles; Pyrroles; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2005 |
Characteristics of sulfur response in a micro-flame photometric detector.
Topics: Microchemistry; Photometry; Sulfhydryl Compounds; Sulfides; Sulfur; Thiophenes | 2006 |
Induction of apoptosis by photoexcited tetracyclic compounds derivatives of benzo[b]thiophenes and pyridines.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or More Rings; HL-60 Cells; Humans; Jurkat Cells; Photosensitizing Agents; Pyridines; Pyrimidinones; Thiophenes | 2006 |
Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.
Topics: Amines; Antioxidants; Ascorbic Acid; Catalysis; Free Radical Scavengers; Oxidation-Reduction; Palladium; Structure-Activity Relationship; Thiophenes | 2006 |
New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity.
Topics: Circular Dichroism; Cyclization; HIV Reverse Transcriptase; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiophenes | 2006 |
The reaction of o-alkynylarene and heteroarene carboxaldehyde derivatives with iodonium ions and nucleophiles: a versatile and regioselective synthesis of 1H-isochromene, naphthalene, indole, benzofuran, and benzothiophene compounds.
Topics: Aldehydes; Alkynes; Benzofurans; Benzopyrans; Heterocyclic Compounds; Indoles; Ions; Naphthalenes; Onium Compounds; Pyridines; Thiophenes | 2006 |
Biodesulfurization of alkylated forms of dibenzothiophene and benzothiophene by Sphingomonas subarctica T7b.
Topics: Alkanes; Biodegradation, Environmental; Biotechnology; Hydrocarbons; Phenol; Soil Microbiology; Sphingomonas; Substrate Specificity; Sulfur; Thiophenes; Time Factors | 2006 |
Gold-catalyzed intramolecular carbothiolation of alkynes: synthesis of 2,3-disubstituted benzothiophenes from (alpha-alkoxy alkyl) (ortho-alkynyl phenyl) sulfides.
Topics: Alkynes; Benzene Derivatives; Catalysis; Gold; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sulfides; Thiophenes | 2006 |
Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
Topics: Animals; Cell Proliferation; Cells, Cultured; DNA Damage; Estrogen Receptor Modulators; Estrogens; Genes, Reporter; Humans; Intestine, Small; Microsomes; Molecular Structure; Oxidation-Reduction; Piperidines; Rats; Thiophenes | 2006 |
Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series.
Topics: Amines; Anti-Infective Agents; Bacteria; Fungi; In Vitro Techniques; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2006 |
[Isolation and characterization of a benzothiophene-desulfurizing bacterium].
Topics: Gordonia Bacterium; Phylogeny; RNA, Ribosomal, 16S; Soil Microbiology; Sulfur; Thiophenes | 2006 |
Synthesis and evaluation of benzothiophene derivatives as ligands for imaging beta-amyloid plaques in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Fluorine Radioisotopes; Humans; Isotope Labeling; Ligands; Radionuclide Imaging; Radiopharmaceuticals; Thiophenes | 2006 |
Sulfur from benzothiophene and alkylbenzothiophenes supports growth of Rhodococcus sp. strain JVH1.
Topics: Agar; Biodegradation, Environmental; Chemistry; Dose-Response Relationship, Drug; Models, Chemical; Rhodococcus; Sulfides; Sulfur; Thiophenes; Time Factors; Water | 2007 |
A systematic resolution of sulfur in reticulated vitreous carbon using X-ray absorption spectroscopy.
Topics: Absorption; Carbon; Disulfides; Heterocyclic Compounds; Models, Chemical; Oxidation-Reduction; Spectrum Analysis; Sulfates; Sulfur; Sulfur Compounds; Thermodynamics; Thiophenes; X-Rays | 2006 |
Synthesis of oxadiazoles, thiadiazoles and triazoles derived from benzo[b]thiophene.
Topics: Oxadiazoles; Thiadiazoles; Thiophenes; Triazoles | 2005 |
Synthesis of benzo[b]thiophenes by cyclization of arylketene dithioacetal monoxides under pummerer-like conditions.
Topics: Acetals; Cyclization; Thiophenes | 2007 |
Amino acid derivatives as histone deacetylase inhibitors.
Topics: Amino Acids; Drug Screening Assays, Antitumor; HCT116 Cells; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Piperazines; Structure-Activity Relationship; Thiophenes | 2008 |
Derivatives of thianaphthene.
Topics: Thiophenes | 1948 |
alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Colon; Cyclopentanes; Dipeptides; Glycine; Guinea Pigs; Muscle Contraction; Receptors, Neurokinin-2; Thiophenes | 2008 |
Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carrageenan; Edema; Liver; Mice; Pain; Pain Threshold; Piroxicam; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiophenes | 2009 |
Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety.
Topics: Amines; Antifungal Agents; Arthrodermataceae; Aspergillus; Candida; Dose-Response Relationship, Drug; Flow Cytometry; Microbial Sensitivity Tests; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Thiophenes | 2008 |
Studies in the thianaphthene series; aminothianaphthene-1-dioxides.
Topics: Humans; Oxygen Compounds; Thiophenes | 1948 |
Some 1:3-oxazine derivatives of thionaphthen.
Topics: Oxazines; Thiophenes | 1948 |
Bacteriostasis in the amino-acid series; derivatives of alanine.
Topics: Alanine; Amino Acids; Bacteria; Thiophenes; Thiram | 1948 |
Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Drug Design; Humans; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Rats; Selective Estrogen Receptor Modulators; Tandem Mass Spectrometry; Thiophenes | 2009 |
Palladium-catalysed direct synthesis of benzo[b]thiophenes from thioenols.
Topics: Catalysis; Cyclization; Molecular Structure; Palladium; Stereoisomerism; Sulfhydryl Compounds; Thiophenes | 2008 |
Microbial transformation of benzothiophenes, with carbazole as the auxiliary substrate, by Sphingomonas sp. strain XLDN2-5.
Topics: Biodegradation, Environmental; Carbazoles; Culture Media; Gas Chromatography-Mass Spectrometry; Sphingomonas; Thiophenes | 2008 |
Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation.
Topics: Antineoplastic Agents; Cyclization; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Pyrans; Structure-Activity Relationship; Thiophenes | 2009 |
In situ growing and patterning of aligned organic nanowire arrays via dip coating.
Topics: Molecular Structure; Nanotechnology; Nanowires; Particle Size; Solutions; Surface Properties; Thiophenes; Xylenes | 2009 |
QSAR model for predicting radical scavenging activity of di(hetero)arylamines derivatives of benzo[b]thiophenes.
Topics: Amines; Drug Design; Free Radical Scavengers; Methods; Quantitative Structure-Activity Relationship; Thiophenes | 2009 |
Application of a rhodium-catalyzed addition/cyclization sequence toward the synthesis of polycyclic heteroaromatics.
Topics: Alkenes; Benzofurans; Boronic Acids; Catalysis; Cyclization; Esters; Heterocyclic Compounds; Indoles; Polycyclic Compounds; Rhodium; Thiophenes | 2009 |
Fragmentation pathways of some benzothiophene radical cations formed by atmospheric pressure chemical ionisation.
Topics: Atmospheric Pressure; Cations; Chromatography, Gas; Chromatography, Liquid; Computer Simulation; Free Radicals; Models, Chemical; Spectrometry, Mass, Electrospray Ionization; Thiophenes | 2009 |
Biodegradation of thiodiglycol, a hydrolyzate of the chemical weapon Yperite, by benzothiophene-desulfurizing bacteria.
Topics: Biodegradation, Environmental; Chemical Warfare Agents; Hydrolysis; Mustard Gas; Rhodococcus; Sulfhydryl Compounds; Sulfur; Thiophenes | 2009 |
[Functional correlation of dibenzothiophene and benzothiophene desulfurization enzymes].
Topics: Biodegradation, Environmental; Gordonia Bacterium; Oxidoreductases; Oxygenases; Rhodococcus; Thiophenes; Transformation, Bacterial | 2008 |
Efficient second harmonic generation from thin films of V-shaped benzo[b]thiophene based molecules.
Topics: Light; Materials Testing; Membranes, Artificial; Refractometry; Scattering, Radiation; Surface Plasmon Resonance; Thiophenes | 2009 |
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Topics: Amidohydrolases; Animals; Computer Simulation; Enzyme Inhibitors; Humans; Models, Chemical; Piperazines; Piperidines; Rats; Structure-Activity Relationship; Thiophenes; Urea | 2009 |
One-pot synthesis of benzo[b]thiophenes and benzo[b]selenophenes from o-halo-substituted ethynylbenzenes: convenient approach to mono-, bis-, and tris-chalcogenophene-annulated benzenes.
Topics: Acetylene; Benzene Derivatives; Cyclization; Hydrocarbons, Halogenated; Molecular Structure; Organoselenium Compounds; Thiophenes | 2009 |
Potent agonists of the Hedgehog signaling pathway.
Topics: Administration, Oral; Animals; Carboxylic Acids; Cell Line; Chemistry, Pharmaceutical; Drug Design; Hedgehog Proteins; Humans; Mice; Models, Biological; Models, Chemical; Stroke; Structure-Activity Relationship; Thiophenes | 2009 |
Novel Route to 2,3-Substituted Benzo[b]thiophenes via Intramolecular Radical Cyclization.
Topics: Cyclization; Free Radicals; Molecular Structure; Stereoisomerism; Thiophenes | 2009 |
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Topics: Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Humans; MAP Kinase Kinase 2; Protein Kinase Inhibitors; Thiophenes | 2009 |
Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.
Topics: Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Humans; MAP Kinase Kinase 2; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiophenes | 2009 |
Efficient synthesis of benzothiophenes by an unusual palladium-catalyzed vinylic C-S coupling.
Topics: Catalysis; Models, Molecular; Palladium; Sulfur Compounds; Thiophenes; Vinyl Compounds | 2009 |
Intramolecular cross-coupling of gem-dibromoolefins: a mild approach to 2-bromo benzofused heterocycles.
Topics: Alkenes; Benzofurans; Catalysis; Copper; Halogenation; Thiophenes | 2009 |
Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases.
Topics: Alkaline Phosphatase; Animals; Drug Evaluation, Preclinical; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Swine; Thiophenes | 2009 |
As many as six tandem reactions in one step! Unprecedented formation of highly functionalized benzothiophenes.
Topics: Carboxylic Acids; Furans; Ketones; Lactones; Methods; Spiro Compounds; Thiophenes | 2009 |
Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Drug Evaluation, Preclinical; Edema; Fungi; Rats; Rats, Wistar; Spectrum Analysis; Thiophenes | 2010 |
Modulation on C- and N-terminal moieties of a series of potent and selective linear tachykinin NK(2) receptor antagonists.
Topics: Animals; Dipeptides; Drug Design; Guinea Pigs; Humans; Receptors, Neurokinin-2; Structure-Activity Relationship; Thiophenes | 2010 |
Diverse methyl sulfone-containing benzo[b]thiophene library via iodocyclization and palladium-catalyzed coupling.
Topics: Catalysis; Cyclization; Dimethyl Sulfoxide; Iodine; Palladium; Sulfones; Thiophenes | 2010 |
Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.
Topics: Animals; Carbamates; Crystallography, X-Ray; Drug Design; Factor IXa; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thiophenes | 2010 |
Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Topics: Crystallography, X-Ray; Factor IXa; Fibrinolytic Agents; Humans; Models, Molecular; Protein Binding; Recombinant Proteins; Structure-Activity Relationship; Thiophenes | 2010 |
Novel benzothiophene H1-antihistamines for the treatment of insomnia.
Topics: Histamine H1 Antagonists; Humans; Receptors, Histamine H1; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship; Thiophenes | 2010 |
Pharmacophore mapping of arylamino-substituted benzo[b]thiophenes as free radical scavengers.
Topics: Computational Biology; Free Radical Scavengers; Models, Molecular; Quantitative Structure-Activity Relationship; Software; Thiophenes | 2010 |
Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.
Topics: Electrons; Hydrogen Peroxide; Oxidation-Reduction; Phosphorus Compounds; Sulfones; Temperature; Thiophenes; Water | 2010 |
Synthesis, electrochemical, and optical properties of new fluorescent, substituted thieno[3,2-b][1]benzothiophenes.
Topics: Absorption; Chemistry, Physical; Electrochemistry; Fluorescence; Molecular Structure; Optical Phenomena; Oxidation-Reduction; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Thiophenes | 2010 |
One-pot synthesis of amine-substituted aryl sulfides and benzo[b]thiophene derivatives.
Topics: Amines; Molecular Structure; Stereoisomerism; Sulfides; Thiophenes | 2010 |
Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma.
Topics: Animals; Disease Models, Animal; Glaucoma; Haplorhini; HeLa Cells; Humans; Intraocular Pressure; Ocular Hypertension; Protein Kinase Inhibitors; rho-Associated Kinases; Thiophenes | 2010 |
New cyclopalladated benzothiophenes: a catalyst precursor for the Suzuki coupling of deactivated aryl chlorides.
Topics: Antineoplastic Agents; Apoptosis; Catalysis; Cell Line, Tumor; Cell Membrane Permeability; Chlorine; Humans; Inhibitory Concentration 50; Organometallic Compounds; Palladium; Thiophenes | 2010 |
Toward the discovery of new agents able to inhibit the expression of microsomal prostaglandin E synthase-1 enzyme as promising tools in drug development.
Topics: 4-Butyrolactone; Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Drug Discovery; Gene Expression; Intramolecular Oxidoreductases; Macrophages; Mice; Microsomes; Oleanolic Acid; Prostaglandin-E Synthases; Thiophenes | 2010 |
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.
Topics: Adenylyl Cyclases; Benzofurans; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Indoles; Protein Binding; Receptors, Dopamine D2; Thiophenes | 2010 |
Benzo[b]thiophene-6-carboxamide 1,1-dioxides: inhibitors of human cancer cell growth at nanomolar concentrations.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Neoplasms; Reactive Oxygen Species; Thiophenes | 2010 |
Fragment-based screen against HIV protease.
Topics: Binding Sites; Carboxylic Acids; Catalytic Domain; Crystallography, X-Ray; Cyclohexanols; HIV Protease; HIV Protease Inhibitors; Humans; Hydrogen Bonding; Recombinant Proteins; Thiophenes | 2010 |
Indole- and benzothiophene-based histamine H3 antagonists.
Topics: Animals; Ether-A-Go-Go Potassium Channels; Histamine H3 Antagonists; Indicators and Reagents; Indoles; Isomerism; Models, Molecular; Rats; Structure-Activity Relationship; Thiophenes | 2010 |
Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openers.
Topics: Animals; Benzofurans; Benzothiazoles; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; HEK293 Cells; Humans; KATP Channels; Molecular Conformation; Potassium Channels, Inwardly Rectifying; Structure-Activity Relationship; Thioamides; Thiophenes | 2010 |
Crystal structure prediction and isostructurality of three small molecules.
Topics: Crystallization; Crystallography, X-Ray; Models, Chemical; Molecular Conformation; Molecular Structure; Thermodynamics; Thiophenes | 2010 |
Synthesis of regioselectively functionalized benzo[b]thiophenes by combined ortho-lithiation-halocyclization strategies.
Topics: Carbamates; Cyclization; Phenol; Stereoisomerism; Substrate Specificity; Thiophenes | 2010 |
3-substituted thianaphthenes.
Topics: Naphthols; Thiophenes | 1945 |
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.
Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Dogs; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Fluorinated; Lipoxygenase Inhibitors; Rats; Structure-Activity Relationship; Thiophenes; Triazoles | 2010 |
Electrochromic thin films from a redox active diarylethene by electrochemical polymerization.
Topics: Benzene Derivatives; Electrochemistry; Ethylenes; Oxidation-Reduction; Polymerization; Polymers; Thiophenes | 2010 |
The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.
Topics: Cell Line; Humans; Protein Binding; Receptors, Prostaglandin E, EP4 Subtype; Structure-Activity Relationship; Thiophenes | 2011 |
Solution-processable organic single crystals with bandlike transport in field-effect transistors.
Topics: Crystallization; Solvents; Thiophenes; Transistors, Electronic | 2011 |
Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase.
Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Hydro-Lyases; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Thiophenes | 2011 |
Synthesis, photophysical characterization, and enzymatic incorporation of a microenvironment-sensitive fluorescent uridine analog.
Topics: DNA-Directed RNA Polymerases; Fluorescent Dyes; Molecular Structure; Oligonucleotides, Antisense; Palladium; RNA; Sequence Homology, Nucleic Acid; Thiophenes; Uridine; Uridine Triphosphate | 2011 |
Photon-quantitative reaction of a dithiazolylarylene in solution.
Topics: Crystallography, X-Ray; Heterocyclic Compounds; Hexanes; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Conformation; Photons; Quantum Theory; Solutions; Temperature; Thiophenes; Ultraviolet Rays | 2011 |
Investigation on the binding mode of benzothiophene analogues as potent factor IXa (FIXa) inhibitors in thrombosis by CoMFA, docking and molecular dynamic studies.
Topics: Binding Sites; Databases, Factual; Factor IXa; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Quantitative Structure-Activity Relationship; Thiophenes; Thrombosis | 2011 |
Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.
Topics: Antidepressive Agents; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Thiophenes | 2011 |
Synthesis, structure and cytotoxicity of 3-C, N, S, Se substituted benzo[b]selenophene derivatives.
Topics: Acridine Orange; Animals; Antineoplastic Agents; Apoptosis; Carbon; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Fibroblasts; Fibrosarcoma; Humans; Inhibitory Concentration 50; Liver Neoplasms; Mice; Microscopy, Fluorescence; Models, Molecular; Nitrogen; Selenium; Structure-Activity Relationship; Sulfur; Thiophenes | 2011 |
Palladium-catalyzed three-component domino reaction for the preparation of benzo[b]thiophene and related compounds.
Topics: Catalysis; Molecular Structure; Organometallic Compounds; Palladium; Stereoisomerism; Thiophenes | 2011 |
A practical, one-pot synthesis of highly substituted thiophenes and benzo[b]thiophenes from bromoenynes and o-alkynylbromobenzenes.
Topics: Alkenes; Alkynes; Bromobenzenes; Molecular Structure; Thiophenes | 2011 |
Synthesis of benzothiophene derivatives by Pd-catalyzed or radical-promoted heterocyclodehydration of 1-(2-mercaptophenyl)-2-yn-1-ols.
Topics: Aldehydes; Biological Products; Catalysis; Chemistry, Pharmaceutical; Cyclization; Free Radicals; Ketones; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium; Stereoisomerism; Sulfhydryl Compounds; Thiophenes | 2011 |
Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase.
Topics: Antimalarials; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Thiophenes | 2011 |
Benzothiophene carboxamide derivatives as novel antimalarials.
Topics: Animals; Antimalarials; Disease Models, Animal; Malaria, Falciparum; Mice; Plasmodium berghei; Plasmodium falciparum; Thiophenes; Trophozoites | 2011 |
Bacterial dioxygenase- and monooxygenase-catalysed sulfoxidation of benzo[b]thiophenes.
Topics: Crystallography, X-Ray; Dioxygenases; Escherichia coli; Multienzyme Complexes; Oxidation-Reduction; Oxygenases; Pseudomonas putida; Sulfoxides; Thiophenes | 2012 |
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Breast; Catechols; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA Adducts; Enzyme Induction; Epithelial Cells; Estrogens; Female; Histone Deacetylase Inhibitors; Horses; Humans; Oxidation-Reduction; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes | 2011 |
Argentation chromatography for the separation of polycyclic aromatic compounds according to ring number.
Topics: Chromatography, Thin Layer; Mass Spectrometry; Molecular Structure; Petroleum; Polycyclic Aromatic Hydrocarbons; Silver; Sulfhydryl Compounds; Thiophenes | 2012 |
Oxidative desulfurization of benzothiophene and thiophene with WOx/ZrO2 catalysts: effect of calcination temperature of catalysts.
Topics: Adsorption; Air Pollution; Catalysis; Kinetics; Nitrogen; Oxidation-Reduction; Oxides; Spectrum Analysis, Raman; Sulfur; Temperature; Thiophenes; Tungsten; X-Ray Diffraction; Zirconium | 2012 |
Toward the accurate analysis of C1-C4 polycyclic aromatic sulfur heterocycles.
Topics: Algorithms; Coal Tar; Gas Chromatography-Mass Spectrometry; Isomerism; Petroleum; Polycyclic Aromatic Hydrocarbons; Sulfur; Thiophenes | 2012 |
Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: the benzothiophene ring as an effective moiety.
Topics: Antiviral Agents; Heterocyclic Compounds; HIV Protease Inhibitors; HIV-1; Humans; Inhibitory Concentration 50; Molecular Structure; Thiophenes | 2012 |
High-molecular weight sulfur-containing aromatics refractory to weathering as determined by Fourier transform ion cyclotron resonance mass spectrometry.
Topics: Cyclotrons; Fourier Analysis; Mass Spectrometry; Petroleum; Petroleum Pollution; Polycyclic Aromatic Hydrocarbons; Thiophenes; Weather | 2012 |
Management of singlet and triplet excitons in a single emission layer: a simple approach for a high-efficiency fluorescence/phosphorescence hybrid white organic light-emitting device.
Topics: Luminescent Measurements; Quantum Theory; Thiophenes | 2012 |
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Topics: Arachidonate 5-Lipoxygenase; Carboxylic Acids; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Protein Binding; Structure-Activity Relationship; Thiophenes | 2012 |
Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions.
Topics: Amides; Benzofurans; Chlorides; Esters; Indoles; Organophosphorus Compounds; Thiophenes | 2012 |
Toluene dioxygenase-catalyzed cis-dihydroxylation of benzo[b]thiophenes and benzo[b]furans: synthesis of benzo[b]thiophene 2,3-oxide.
Topics: Benzofurans; Biocatalysis; Crystallography, X-Ray; Hydroxylation; Models, Molecular; Molecular Structure; Oxygenases; Stereoisomerism; Thiophenes | 2012 |
Low-temperature loading of Cu+ species over porous metal-organic frameworks (MOFs) and adsorptive desulfurization with Cu+-loaded MOFs.
Topics: Adsorption; Benzene Derivatives; Copper; Iron; Porosity; Sulfur; Temperature; Thiophenes; Tricarboxylic Acids | 2012 |
Photochemical electrocyclic ring closure and leaving group expulsion from N-(9-oxothioxanthenyl)benzothiophene carboxamides.
Topics: Cyclization; Electrons; Molecular Structure; Photochemical Processes; Solubility; Thiophenes; Thioxanthenes | 2013 |
Visible light photocatalytic synthesis of benzothiophenes.
Topics: Catalysis; Light; Molecular Structure; Oxidation-Reduction; Photochemical Processes; Thiophenes | 2012 |
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.
Topics: Antimitotic Agents; Benzofurans; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colchicine; Heterocyclic Compounds; Humans; Indoles; Microscopy, Confocal; Microtubules; Stereoisomerism; Stilbenes; Thiophenes | 2012 |
Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes.
Topics: Catalysis; Combinatorial Chemistry Techniques; Copper; Molecular Structure; Palladium; Silanes; Thiophenes | 2012 |
Neutron and X-ray crystal structures of a perdeuterated enzyme inhibitor complex reveal the catalytic proton network of the Toho-1 β-lactamase for the acylation reaction.
Topics: Acylation; beta-Lactamases; Catalysis; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Hydrogen; Hydrogen Bonding; Ligands; Models, Chemical; Molecular Conformation; Neutrons; Nitrogen; Protons; Thiophenes | 2013 |
Direct access to pyrazolo(benzo)thienoquinolines. Highly effective palladium catalysts for the intramolecular C-H heteroarylation of arenes.
Topics: Carbon; Catalysis; Hydrogen; Palladium; Pyrazoles; Quinolines; Thiophenes | 2013 |
Cu-catalyzed in situ generation of thiol using xanthate as a thiol surrogate for the one-pot synthesis of benzothiazoles and benzothiophenes.
Topics: Benzothiazoles; Catalysis; Copper; Molecular Structure; Organometallic Compounds; Sulfhydryl Compounds; Thiophenes; Xanthines | 2013 |
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Topics: Benzofurans; Cell Line, Tumor; Cell Survival; Humans; Imidazoles; Melanoma; Naphthols; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Structure-Activity Relationship; Thiophenes | 2013 |
Synthesis, fine structure of 19F NMR and fluorescence of novel amorphous TPA derivatives having perfluorinated cyclopentenyl and benzo[b]thiophene unit.
Topics: Aniline Compounds; Cyclopentanes; Fluorescent Dyes; Fluorocarbons; Magnetic Resonance Spectroscopy; Models, Molecular; Spectrometry, Fluorescence; Terphenyl Compounds; Thiophenes | 2013 |
Adsorptive denitrogenation of model fuels with porous metal-organic framework (MOF) MIL-101 impregnated with phosphotungstic acid: effect of acid site inclusion.
Topics: Adsorption; Catalysis; Environmental Pollutants; Fossil Fuels; Indoles; Metals; Nitrogen; Organic Chemicals; Phosphotungstic Acid; Porosity; Quinolines; Solvents; Thiophenes; Waste Disposal, Fluid; X-Ray Diffraction | 2013 |
Completely regioselective direct C-H functionalization of benzo[b]thiophenes using a simple heterogeneous catalyst.
Topics: Catalysis; Molecular Structure; Palladium; Stereoisomerism; Thiophenes | 2013 |
Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.
Topics: Cell Survival; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Protein Binding; Thiophenes | 2013 |
Iridium-catalyzed hydrogen transfer: synthesis of substituted benzofurans, benzothiophenes, and indoles from benzyl alcohols.
Topics: Benzofurans; Benzyl Alcohols; Catalysis; Indoles; Iridium; Molecular Structure; Stereoisomerism; Thiophenes | 2013 |
Effect of central metal ions of analogous metal-organic frameworks on the adsorptive removal of benzothiophene from a model fuel.
Topics: Adsorption; Air Pollution; Aluminum; Benzene Derivatives; Catalysis; Chromium; Copper; Fossil Fuels; Ions; Metals; Oxidation-Reduction; Oxygen; Porosity; Thiophenes; Time Factors; Tricarboxylic Acids; Vanadium; X-Ray Diffraction | 2013 |
[Developing FGFR inhibitors as potential anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Computer Simulation; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mutation; Neoplasms; Oxindoles; Receptors, Fibroblast Growth Factor; Thiophenes; Up-Regulation | 2013 |
Fullerene derivative-doped zinc oxide nanofilm as the cathode of inverted polymer solar cells with low-bandgap polymer (PTB7-Th) for high performance.
Topics: Electrodes; Fullerenes; Nanostructures; Polymers; Quantum Theory; Solar Energy; Thiophenes; Zinc Oxide | 2013 |
Copper-catalyzed synthesis of benzo[b]thiophenes and benzothiazoles using thiocarboxylic acids as a coupling partner.
Topics: Benzothiazoles; Carboxylic Acids; Catalysis; Copper; Molecular Structure; Sulfhydryl Compounds; Thiophenes | 2013 |
Versatile synthesis of benzothiophenes and benzoselenophenes by rapid assembly of arylzinc reagents, alkynes, and elemental chalcogens.
Topics: Alkynes; Chalcogens; Cyclization; Organometallic Compounds; Selenium Compounds; Thiophenes; Zinc | 2013 |
Discovery of synthetic Leishmania inhibitors by screening of a 2-arylbenzothiophene library.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Chlorocebus aethiops; Drug Evaluation, Preclinical; Leishmania; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vero Cells | 2014 |
Characterization of telmisartan-derived PPARγ agonists: importance of moiety shift from position 6 to 5 on potency, efficacy and cofactor recruitment.
Topics: 3T3-L1 Cells; Animals; Benzimidazoles; Benzoates; Benzofurans; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Type 2; Humans; Ligands; Mice; PPAR gamma; Structure-Activity Relationship; Telmisartan; Thiophenes | 2012 |
Inhibitors of tissue-nonspecific alkaline phosphatase: design, synthesis, kinetics, biomineralization and cellular tests.
Topics: Alkaline Phosphatase; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Kinetics; Levamisole; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2013 |
Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties.
Topics: Anilides; Antineoplastic Agents; Cell Line, Tumor; Cytostatic Agents; DNA; Drug Screening Assays, Antitumor; Humans; Neoplasms; Nitrogen; Quantitative Structure-Activity Relationship; Quinolones; Thiophenes; Topoisomerase II Inhibitors | 2014 |
Genetic analysis of benzothiophene biodesulfurization pathway of Gordonia terrae strain C-6.
Topics: Actinomycetales; Cell Proliferation; Computer Simulation; Culture Techniques; Gene Expression Profiling; Molecular Sequence Data; Sulfur; Thiophenes | 2013 |
Application of liquid-phase microextraction for the determination of sulfur compounds in crude oil and diesel.
Topics: Chromatography, Gas; Gasoline; Liquid Phase Microextraction; Petroleum; Sulfur Compounds; Thiophenes | 2014 |
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Topics: Acyltransferases; Animals; Antimalarials; Blood; Chloroquine; Crystallography, X-Ray; Drug Design; Drug Resistance; Humans; Hydrogen Bonding; Indicators and Reagents; Ligands; Lipids; Liver; Mice; Models, Molecular; Molecular Conformation; Plasmodium falciparum; Plasmodium vivax; Structure-Activity Relationship; Thiophenes | 2014 |
Charge transfer emission of T-shaped π-conjugated molecules: impact of quinoid character on the excited state properties.
Topics: Benzimidazoles; Molecular Structure; Quinones; Thiophenes | 2014 |
Synthesis and fungicidal activities of novel benzothiophene-substituted oxime ether strobilurins.
Topics: Fatty Acids, Unsaturated; Fungi; Fungicides, Industrial; Methacrylates; Oximes; Strobilurins; Thiophenes | 2014 |
A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes.
Topics: Benzofurans; Chemistry Techniques, Synthetic; Thiophenes | 2014 |
Asymmetric dearomatic Diels-Alder reactions of diverse heteroarenes via π-system activation.
Topics: Amines; Benzofurans; Catalysis; Cycloaddition Reaction; Furans; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Stereoisomerism; Thiophenes | 2014 |
Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.
Topics: Allosteric Regulation; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Stability; Hepatocytes; Humans; Ketoglutarate Dehydrogenase Complex; Mice; Mice, Knockout; Proteolysis; Thiophenes | 2014 |
Bioremediation of coking wastewater containing carbazole, dibenzofuran and dibenzothiophene by immobilized naphthalene-cultivated Arthrobacter sp. W1 in magnetic gellan gum.
Topics: Arthrobacter; Benzofurans; Biodegradation, Environmental; Carbazoles; Cells, Immobilized; Coke; Kinetics; Nanoparticles; Polysaccharides, Bacterial; Thiophenes; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2014 |
Oxidation of benzothiophene, dibenzothiophene, and methyl-dibenzothiophene by ferrate(VI).
Topics: Catalysis; Gasoline; Hydrogen-Ion Concentration; Iron; Manganese Compounds; Oxidation-Reduction; Silicon Dioxide; Thiophenes | 2014 |
Stereoselective synthesis of C-fused pyranoindoles, pyranobenzofurans and pyranobenzothiophene scaffolds using oxa-Pictet-Spengler type reaction of vinylogous carbonates.
Topics: Benzofurans; Indoles; Molecular Structure; Pyrans; Stereoisomerism; Thiophenes | 2014 |
Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Progression; Estrogens; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Random Allocation; Receptors, Estrogen; Tamoxifen; Thiophenes; Transfection; Xenograft Model Antitumor Assays | 2014 |
Isolation and classification of a soil actinomycete capable of sulphur-specific biotransformation of dibenzothiophene, benzothiophene and thianthrene.
Topics: Actinobacteria; Actinomycetales; Biotransformation; Heterocyclic Compounds; Petroleum; Rhodococcus; Soil Microbiology; Soil Pollutants; Thiophenes | 2015 |
An unexpected reaction of 2-alkynylaryldiazonium tetrafluoroborate with sulfur dioxide.
Topics: Amines; Borates; Boric Acids; Bromides; Catalysis; Copper; Crystallography, X-Ray; Cyclization; Diazonium Compounds; Molecular Conformation; Oxides; Sulfur Dioxide; Thiophenes | 2015 |
Access to polysubstituted indoles or benzothiophenes via palladium-catalyzed cross-coupling of furfural tosylhydrazones with 2-iodoanilines or 2-iodothiophenols.
Topics: Aniline Compounds; Catalysis; Hydrazones; Indoles; Molecular Structure; Organometallic Compounds; Palladium; Phenols; Thiophenes; Tosyl Compounds | 2015 |
Quantitative analysis of structure-activity relationships of tetrahydro-2H-isoindole cyclooxygenase-2 inhibitors.
Topics: Cyclooxygenase 2 Inhibitors; Isoindoles; Models, Molecular; Quantitative Structure-Activity Relationship; Thiophenes | 2015 |
Tandem Thien- and benzannulations of α-alkenoyl-α-alkynyl ketene dithioacetals with cyanoacetates: synthesis of functionalized benzo[b]thiophenes.
Topics: Acetals; Acetates; Alkenes; Ethylenes; Ketones; Molecular Structure; Temperature; Thiophenes | 2015 |
Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Cell Line; Female; Glucocorticoids; Male; Mice; Mice, Inbred Strains; Osteoporosis; Rats; Rats, Wistar; Thiophenes; Up-Regulation | 2015 |
Theoretical investigation of the interaction between aromatic sulfur compounds and [BMIM](+)[FeCl4](-) ionic liquid in desulfurization: A novel charge transfer mechanism.
Topics: Electrons; Ionic Liquids; Ions; Iron; Sulfur Compounds; Thiophenes | 2015 |
Application of Thio-Ugi Adducts for the Preparation of Benzo[b]thiophene and S-Heterocycle Library via Copper Catalyzed Intramolecular C-S Bond Formation.
Topics: Carbon; Catalysis; Combinatorial Chemistry Techniques; Copper; Heterocyclic Compounds; Indicators and Reagents; Magnetic Resonance Spectroscopy; Microwaves; Sulfur; Thiazepines; Thiophenes | 2015 |
Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors.
Topics: Cell Line, Tumor; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Models, Molecular; NF-kappa B; Thiophenes; Transcription Factor AP-1; Tubulin | 2015 |
Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.
Topics: Amination; Humans; Lim Kinases; MAP Kinase Kinase 2; Microwaves; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Thiophenes | 2015 |
Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
Topics: Antineoplastic Agents; Benzofurans; Benzothiazoles; Binding Sites; Cell Line, Tumor; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Resveratrol; Stilbenes; Thiophenes; Tubulin | 2015 |
Stereospecific nickel-catalyzed cross-coupling reactions of benzylic ethers and esters.
Topics: Antineoplastic Agents; Catalysis; Esters; Ethers; Furans; Methane; Naphthalenes; Nickel; Oxidation-Reduction; Stereoisomerism; Thiophenes | 2015 |
C2 Arylated Benzo[b]thiophene Derivatives as Staphylococcus aureus NorA Efflux Pump Inhibitors.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Multidrug Resistance-Associated Proteins; Staphylococcus; Structure-Activity Relationship; Thiophenes | 2016 |
Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.
Topics: Amides; Antineoplastic Agents; Apoptosis; Binding Sites; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Hep G2 Cells; Humans; Molecular Docking Simulation; Nicotinamide Phosphoribosyltransferase; Structure-Activity Relationship; Thiophenes | 2016 |
Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Doxorubicin; Humans; MCF-7 Cells; Structure-Activity Relationship; Thiophenes | 2016 |
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors.
Topics: Administration, Oral; Biological Availability; Dose-Response Relationship, Drug; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiophenes | 2016 |
Novel 2-Thienyl- and 2-Benzothienyl-Substituted 6-(2-Imidazolinyl)Benzothiazoles: Synthesis; in vitro Evaluation of Antitumor Effects and Assessment of Mitochondrial Toxicity.
Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mitochondria; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Thiophenes | 2017 |
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Drug Design; Humans; Molecular Docking Simulation; Protein Binding; Protein Conformation; Receptor, Cannabinoid, CB2; Thiophenes | 2016 |
Novel benzothiophene 1,1-dioxide deoxygenation path for the microwave-assisted synthesis of substituted benzothiophene-fused pyrrole derivatives.
Topics: Chemistry Techniques, Synthetic; Microwaves; Models, Molecular; Molecular Conformation; Oxygen; Pyrroles; Thiophenes | 2017 |
Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Oxides; STAT3 Transcription Factor; Thiophenes | 2017 |
Catalyst-Free Formal Thioboration to Synthesize Borylated Benzothiophenes and Dihydrothiophenes.
Topics: Alkynes; Boron; Carbon; Crystallography, X-Ray; Cyclization; Molecular Conformation; Quantum Theory; Thiophenes | 2016 |
Variation in toxicity during the biodegradation of various heterocyclic and homocyclic aromatic hydrocarbons in single and multi-substrate systems.
Topics: Benzofurans; Biodegradation, Environmental; Chryseobacterium; Environmental Pollutants; Escherichia coli; Hydrocarbons, Aromatic; Naphthalenes; Oxidoreductases; Pseudomonas fluorescens; Quinolones; Thiophenes | 2017 |
A benzo[b]thiophene-based selective type 4 S1P receptor agonist.
Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Receptors, Lysosphingolipid; Structure-Activity Relationship; Thiophenes | 2017 |
Methacrylate-bonded covalent-organic framework monolithic columns for high performance liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Hydrophobic and Hydrophilic Interactions; Methacrylates; Phenols; Polycyclic Aromatic Hydrocarbons; Polymers; Porosity; Temperature; Thiophenes | 2017 |
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Mice, Nude; Models, Molecular; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes | 2017 |
Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.
Topics: Benzimidazoles; Cannabinoids; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Static Electricity; Thiophenes | 2017 |
Biodesulphurization of gasoline by Rhodococcus erythropolis supported on polyvinyl alcohol.
Topics: Biodegradation, Environmental; Gas Chromatography-Mass Spectrometry; Gasoline; Hexanes; Microscopy, Electron, Scanning; Polyvinyl Alcohol; Rhodococcus; Solvents; Spectroscopy, Fourier Transform Infrared; Sulfur; Thiophenes | 2017 |
Novel 2-phenyl-4,5,6,7-tetrahydro[b]benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation, and molecular docking studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2 Inhibitors; Drug Design; Edema; Mice; Molecular Docking Simulation; Rats; RAW 264.7 Cells; Thiophenes | 2017 |
New benzothiophene derivatives as dual COX-1/2 and 5-LOX inhibitors: synthesis, biological evaluation and docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Edema; Formaldehyde; Humans; Lipoxygenase Inhibitors; Molecular Docking Simulation; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiophenes | 2017 |
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzofurans; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Formaldehyde; Lipoxygenase Inhibitors; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Wistar; Rhodanine; Structure-Activity Relationship; Thiophenes | 2017 |
A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Rhinovirus; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes; Virus Replication | 2017 |
Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE.
Topics: Binding Sites; Catalytic Domain; Cell Line; Cell Survival; Cysteine Proteases; Cysteine Proteinase Inhibitors; Humans; Inhibitory Concentration 50; Leishmania mexicana; Molecular Docking Simulation; Protozoan Proteins; Structure-Activity Relationship; Thiophenes | 2018 |
Uses of Cyclohexan-1,4-dione for the Synthesis of 2-Amino-4,5-dihydrobenzo[b]thiophen-6(7H)-one Derivatives with Anti-proliferative and Pim-1 Kinase Activities.
Topics: A549 Cells; Animals; Antineoplastic Agents; Artemia; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-pim-1; Structure-Activity Relationship; Thiophenes | 2017 |
Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Rats; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tetrazoles; Thiophenes | 2018 |
Biodesulfurization of Thiophenic Compounds by a 2-Hydroxybiphenyl-Resistant Gordonia sp. HS126-4N Carrying dszABC Genes.
Topics: Bacterial Proteins; Biotransformation; Biphenyl Compounds; Fossil Fuels; Gordonia Bacterium; Mass Spectrometry; Molecular Structure; Sulfur; Thiophenes | 2018 |
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
Topics: Animals; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Calcium; Dose-Response Relationship, Drug; Neurons; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides; Thiophenes | 2018 |
New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model.
Topics: Adamantane; Aminoquinolines; Animals; Botulinum Toxins, Type A; Mice; Molecular Docking Simulation; Motor Neurons; Mouse Embryonic Stem Cells; Steroids; Synaptosomal-Associated Protein 25; Thiophenes; Toxicity Tests | 2018 |
Relative Reactivity of Benzothiophene-Fused Enediynes in the Bergman Cyclization.
Topics: Cyclization; DNA Damage; Drug Stability; Enediynes; Models, Molecular; Molecular Conformation; Quantum Theory; Thiophenes | 2018 |
Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers.
Topics: Binding Sites; Breast Neoplasms; Cell Proliferation; Chromatin; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mutation; Protein Binding; Tamoxifen; Thiophenes | 2018 |
Alternative Thieno[3,2-b][1]benzothiophene Isoindigo Polymers for Solar Cell Applications.
Topics: Electric Power Supplies; Electrons; Indoles; Polymers; Solar Energy; Thiophenes | 2018 |
Unraveling the molecular mechanism of benzothiophene and benzofuran scaffold-merged compounds binding to anti-apoptotic Myeloid cell leukemia 1.
Topics: Apoptosis; Benzofurans; Least-Squares Analysis; Molecular Docking Simulation; Molecular Dynamics Simulation; Myeloid Cell Leukemia Sequence 1 Protein; Quantitative Structure-Activity Relationship; Reproducibility of Results; Thiophenes | 2019 |
Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B.
Topics: Amides; Aurora Kinase A; Aurora Kinase B; HCT116 Cells; Humans; Inhibitory Concentration 50; Protein Kinase Inhibitors; Thiophenes | 2018 |
Enantioselective Synthesis of Indolines, Benzodihydrothiophenes, and Indanes by C-H Insertion of Donor/Donor Carbenes.
Topics: Catalysis; Indans; Indoles; Methane; Oxidation-Reduction; Rhodium; Stereoisomerism; Thiophenes | 2018 |
Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ.
Topics: Animals; Epithelial Sodium Channel Agonists; Epithelial Sodium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; Indoles; Mice; Thiophenes | 2019 |
Hydrophilicity-Controlled Conjugated Microporous Polymers for Enhanced Visible-Light-Driven Photocatalytic H
Topics: Catalysis; Hydrogen; Hydrophobic and Hydrophilic Interactions; Light; Particle Size; Photochemical Processes; Polymers; Porosity; Sulfones; Surface Properties; Thiophenes | 2019 |
Sonochemical Degradation of Benzothiophene (BT) in Deionized Water, Natural Water and Sea Water.
Topics: Gas Chromatography-Mass Spectrometry; Ions; Molecular Structure; Oxidation-Reduction; Seawater; Thiophenes; Water; Water Purification | 2019 |
Benzothiophene derivatives as phosphodiesterase 10A (PDE10A) inhibitors: Hit-to-lead studies.
Topics: Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship; Thiophenes | 2019 |
Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Humans; Kinetics; Molecular Docking Simulation; Mutagenesis, Site-Directed; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Structure, Tertiary; Protein Subunits; Receptors, Nicotinic; Recombinant Proteins; Sequence Alignment; Thiophenes; Xenopus laevis | 2019 |
Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors.
Topics: Benzofurans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Isoenzymes; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfonic Acids; Thiophenes | 2019 |
Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; DNA Topoisomerases, Type I; Drug Design; Female; Humans; Molecular Docking Simulation; Quinazolinones; Thiophenes; Topoisomerase I Inhibitors; Tubulin; Tubulin Modulators | 2019 |
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Topics: Animals; Antiprotozoal Agents; Cricetinae; Drug Evaluation, Preclinical; Drug Resistance; Flavonols; Genomics; Humans; Leishmania; Leishmaniasis; Phosphorylcholine; Thiophenes | 2019 |
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.
Topics: Animals; Antioxidants; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Mice; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Structure-Activity Relationship; Thiazoles; Thiophenes; Toxoplasma; Tyrosine 3-Monooxygenase | 2019 |
The Gas-Phase Formation Mechanism of Dibenzofuran (DBF), Dibenzothiophene (DBT), and Carbazole (CA) from Benzofuran (BF), Benzothiophene (BT), and Indole (IN) with Cyclopentadienyl Radical.
Topics: Benzofurans; Carbazoles; Cyclopentanes; Free Radicals; Gases; Indoles; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Polycyclic Aromatic Hydrocarbons; Thiophenes | 2019 |
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.
Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation; Proteolysis; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Human Rhinovirus Inhibition Through Capsid "Canyon" Perturbation: Structural Insights into The Role of a Novel Benzothiophene Derivative.
Topics: Binding Sites; Capsid Proteins; Catalytic Domain; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Rhinovirus; Thermodynamics; Thiophenes | 2020 |
MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy.
Topics: Aging; Animals; Autophagy; Cell Line; Flow Cytometry; Humans; Insulin Secretion; Mice; Mitochondria; Mitochondrial Turnover; Mitophagy; Multienzyme Complexes; Small Molecule Libraries; Thiophenes | 2020 |
Molecular modeling studies of benzothiophene-containing derivatives as promising selective estrogen receptor downregulators: a combination of 3D-QSAR, molecular docking and molecular dynamics simulations.
Topics: Molecular Docking Simulation; Molecular Dynamics Simulation; Quantitative Structure-Activity Relationship; Receptors, Estrogen; Thiophenes | 2021 |
Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants.
Topics: Central Nervous System Stimulants; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Stereoisomerism; Structure-Activity Relationship; Tandem Mass Spectrometry; Thiophenes | 2020 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[
Topics: Alkylation; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Hep G2 Cells; Humans; MCF-7 Cells; Pyrimidinones; Structure-Activity Relationship; Thiophenes | 2020 |
Benzothiophene-2-carboxamide derivatives as SENPs inhibitors with selectivity within SENPs family.
Topics: Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Structure-Activity Relationship; Thiophenes; User-Computer Interface | 2020 |
Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes.
Topics: Anti-Inflammatory Agents; Benzofurans; HEK293 Cells; Humans; Lignans; NF-kappa B; Structure-Activity Relationship; Thiophenes | 2020 |
Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.
Topics: Antineoplastic Agents; Benzofurans; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Phosphoric Diester Hydrolases; Pyrophosphatases; Structure-Activity Relationship; Sulfonic Acids; Thiophenes; Tumor Cells, Cultured | 2020 |
Nanotized curcumin-benzothiophene conjugate: A potential combination for treatment of cerebral malaria.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Biological Availability; Curcumin; Malaria, Cerebral; Malaria, Falciparum; Mice; Mice, Inbred C57BL; Nanoparticles; Plasmodium berghei; Thiophenes | 2020 |
Fast and easily obtained information about mobilizable metals from sediment samples. Extraction assisted by benzothiophene-based ionic liquids.
Topics: Geologic Sediments; Humans; Ionic Liquids; Metals; Thiophenes | 2021 |
Oxidant- and Catalyst-Free Synthesis of Sulfonated Benzothiophenes via Electrooxidative Tandem Cyclization.
Topics: Catalysis; Cyclization; Oxidants; Thiophenes | 2021 |
5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency.
Topics: Cell Line, Tumor; Cell Proliferation; Humans; Models, Molecular; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Substrate Specificity; Thiophenes | 2021 |
Synthesis of ruthenium complexes functionalized with benzothiophene and their antibacterial activity against Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Coordination Complexes; Ruthenium; Staphylococcus aureus; Thiophenes | 2021 |
Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Estrogen Receptor Antagonists; Female; Humans; MCF-7 Cells; Molecular Structure; Receptors, Estrogen; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2021 |
Synthesis of novel artesunate-benzothiophene and artemisinin-benzothiophene derivatives.
Topics: Artemisinins; Artesunate; Biological Products; Palladium; Thiophenes | 2022 |
Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives.
Topics: Antineoplastic Agents; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2021 |
A light-activatable photosensitizer for photodynamic therapy based on a diarylethene derivative.
Topics: Antineoplastic Agents; Ethylenes; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Light; Molecular Conformation; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Stilbenes; Thiophenes | 2021 |
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation.
Topics: alpha-Glucosidases; Animals; Blood Glucose; Cell Line; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Kinetics; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Urea | 2021 |
Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities.
Topics: Dose-Response Relationship, Drug; Drug Design; Estrogen Antagonists; Estrogen Receptor alpha; Humans; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2021 |
Donor/π-Bridge Manipulation for Constructing a Stable NIR-II Aggregation-Induced Emission Luminogen with Balanced Phototheranostic Performance*.
Topics: Density Functional Theory; Fluorescent Dyes; Infrared Rays; Molecular Structure; Nanoparticles; Photosensitizing Agents; Theranostic Nanomedicine; Thiophenes | 2021 |
Poly (4,4'-methylenedianiline)-graphene oxide nanocomposite: synthesize and application in removal of benzothiophene from model liquid fuel.
Topics: Aniline Compounds; Environmental Monitoring; Graphite; Kinetics; Nanocomposites; Thiophenes; Water Pollutants, Chemical | 2021 |
Chemical Space Expansion of Flavonoids: Induction of Mitotic Inhibition by Replacing Ring B with a 10π-Electron System, Benzo[
Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Electrons; Flavonoids; Humans; Mitosis; Structure-Activity Relationship; Thiophenes | 2022 |
New class of benzothiophene morpholine analogues with high selectivity and affinity were designed and evaluated for anti-drug addiction.
Topics: Animals; Ligands; Mice; Morpholines; Radioligand Assay; Receptors, Dopamine D3; Structure-Activity Relationship; Substance-Related Disorders; Thiophenes | 2022 |
Biorecognition Layer Based On Biotin-Containing [1]Benzothieno[3,2-
Topics: Biosensing Techniques; Biotin; Electrolytes; Influenza A Virus, H7N1 Subtype; Reproducibility of Results; Thiophenes | 2022 |
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Topics: Humans; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Thiophenes | 2022 |
Base-Mediated Annulation of Electrophilic Benzothiophene with Naphthols and Phenols: Accessing Benzothiophene-Fused Heteroacenes.
Topics: Furans; Molecular Structure; Naphthols; Phenols; Thiophenes | 2022 |
Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases.
Topics: Benzofurans; Deoxyuridine; DNA; DNA-Directed DNA Polymerase; Nucleotides; Oligonucleotides; Thiophenes | 2022 |
Sustainable access to benzothiophene derivatives bearing a trifluoromethyl group
Topics: Hydrocarbons, Fluorinated; Pyrrolidinones; Solvents; Thiophenes; Water | 2022 |
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists.
Topics: Animals; Humans; Immunotherapy; Interferons; Membrane Proteins; Mice; Neoplasms; Structure-Activity Relationship; Thiophenes; THP-1 Cells | 2022 |
A benzothiophene-quinoline-based targetable fluorescent chemosensor for detection of viscosity and mitochondrial imaging in live cells.
Topics: Fluorescent Dyes; HeLa Cells; Humans; Mitochondria; Optical Imaging; Quinolines; Thiophenes; Viscosity | 2023 |
Catalyst-free electrosynthesis of benzothiophenes from 2-alkenylaryl disulfides.
Topics: Catalysis; Disulfides; Oxidants; Thiophenes | 2022 |
Ruthenium(II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Coordination Complexes; Female; Humans; Ovarian Neoplasms; Ruthenium; Thiophenes | 2023 |
Ultrasound-assisted adsorption approach for desulfurization of n-heptane using nitrogen-doped magnetic carbon dot nanocomposite.
Topics: Adsorption; Carbon; Kinetics; Magnetic Phenomena; Nanocomposites; Nitrogen; Solvents; Thiophenes; Water Pollutants, Chemical | 2023 |