benzothiophene has been researched along with benzofuran in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Brenk, R; Graves, AP; Shoichet, BK | 1 |
| Ballesteros, A; Barluenga, J; González, JM; Merino, I; Vázquez-Villa, H | 1 |
| Lautens, M; Tseng, NW | 1 |
| Babic, S; Calvin, W; Cui, J; Luedtke, RR; Mach, RH; Taylor, M; Vangveravong, S; Xu, J | 1 |
| Braun, M; Fischer, A; Frank, W; Grittner, D; Lachenicht, S; Lemoine, H; Rood, A; Schmidt, C; Winkler, M; Wrobel, T | 1 |
| Allen, CC; Boyd, DR; Brannigan, IN; Evans, TA; Haughey, SA; Malone, JF; McIntyre, PB; McMurray, BT; Sharma, ND; Stevenson, PJ | 1 |
| Abdayem, R; Barret, R; Colomb, E; Dubois, J; Guillaume, J; Haftek, M; Lomberget, T; Nachtergaele, L; Nguyen, TT; Thoret, S; Tran, NC | 1 |
| Davies, L; Marais, R; Ménard, D; Niculescu-Duvaz, D; Niculescu-Duvaz, I; Pons, JF; Springer, CJ; Suijkerbuijk, BM; Whittaker, S; Zambon, A | 1 |
| Bandholtz, S; Goebel, M; Gust, R; Herbst, L; Kintscher, U | 1 |
| Guo, HF; Jin, J; Ju, DH; Li, ZR; Liu, MJ; Liu, ZY; Xue, ST | 1 |
| Crooks, PA; Penthala, NR; Thakkar, S | 1 |
| Oberoi, AS; Philip, L | 1 |
| El-Hawash, SAM; El-Messmary, H; El-Miligy, MMM; Hazzaa, AA; Nassra, RA | 1 |
| Marimuthu, P; Singaravelu, K | 1 |
| Afridi, S; Amjad, ST; Anbar, HS; El-Gamal, MI; El-Gamal, R; Iqbal, J; Shafique, Z; Zaib, S; Zaraei, SO | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Al-Rashida, M; Anbar, HS; El-Gamal, MI; El-Gamal, R; Iqbal, J; Pelletier, J; Sévigny, J; Ullah, S; Zaib, S; Zaraei, SO | 1 |
17 other study(ies) available for benzothiophene and benzofuran
| Article | Year |
|---|---|
Decoys for docking.
Topics: Acetylcholinesterase; Algorithms; Binding Sites; Ligands; Models, Molecular; Protein Binding; Purine-Nucleoside Phosphorylase; Quantitative Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thrombin; Thymidylate Synthase | 2005 |
The reaction of o-alkynylarene and heteroarene carboxaldehyde derivatives with iodonium ions and nucleophiles: a versatile and regioselective synthesis of 1H-isochromene, naphthalene, indole, benzofuran, and benzothiophene compounds.
Topics: Aldehydes; Alkynes; Benzofurans; Benzopyrans; Heterocyclic Compounds; Indoles; Ions; Naphthalenes; Onium Compounds; Pyridines; Thiophenes | 2006 |
Application of a rhodium-catalyzed addition/cyclization sequence toward the synthesis of polycyclic heteroaromatics.
Topics: Alkenes; Benzofurans; Boronic Acids; Catalysis; Cyclization; Esters; Heterocyclic Compounds; Indoles; Polycyclic Compounds; Rhodium; Thiophenes | 2009 |
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.
Topics: Adenylyl Cyclases; Benzofurans; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Indoles; Protein Binding; Receptors, Dopamine D2; Thiophenes | 2010 |
Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openers.
Topics: Animals; Benzofurans; Benzothiazoles; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; HEK293 Cells; Humans; KATP Channels; Molecular Conformation; Potassium Channels, Inwardly Rectifying; Structure-Activity Relationship; Thioamides; Thiophenes | 2010 |
Toluene dioxygenase-catalyzed cis-dihydroxylation of benzo[b]thiophenes and benzo[b]furans: synthesis of benzo[b]thiophene 2,3-oxide.
Topics: Benzofurans; Biocatalysis; Crystallography, X-Ray; Hydroxylation; Models, Molecular; Molecular Structure; Oxygenases; Stereoisomerism; Thiophenes | 2012 |
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.
Topics: Antimitotic Agents; Benzofurans; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colchicine; Heterocyclic Compounds; Humans; Indoles; Microscopy, Confocal; Microtubules; Stereoisomerism; Stilbenes; Thiophenes | 2012 |
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Topics: Benzofurans; Cell Line, Tumor; Cell Survival; Humans; Imidazoles; Melanoma; Naphthols; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Structure-Activity Relationship; Thiophenes | 2013 |
Characterization of telmisartan-derived PPARγ agonists: importance of moiety shift from position 6 to 5 on potency, efficacy and cofactor recruitment.
Topics: 3T3-L1 Cells; Animals; Benzimidazoles; Benzoates; Benzofurans; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Type 2; Humans; Ligands; Mice; PPAR gamma; Structure-Activity Relationship; Telmisartan; Thiophenes | 2012 |
Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Cell Line; Female; Glucocorticoids; Male; Mice; Mice, Inbred Strains; Osteoporosis; Rats; Rats, Wistar; Thiophenes; Up-Regulation | 2015 |
Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
Topics: Antineoplastic Agents; Benzofurans; Benzothiazoles; Binding Sites; Cell Line, Tumor; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Resveratrol; Stilbenes; Thiophenes; Tubulin | 2015 |
Variation in toxicity during the biodegradation of various heterocyclic and homocyclic aromatic hydrocarbons in single and multi-substrate systems.
Topics: Benzofurans; Biodegradation, Environmental; Chryseobacterium; Environmental Pollutants; Escherichia coli; Hydrocarbons, Aromatic; Naphthalenes; Oxidoreductases; Pseudomonas fluorescens; Quinolones; Thiophenes | 2017 |
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzofurans; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Formaldehyde; Lipoxygenase Inhibitors; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Wistar; Rhodanine; Structure-Activity Relationship; Thiophenes | 2017 |
Unraveling the molecular mechanism of benzothiophene and benzofuran scaffold-merged compounds binding to anti-apoptotic Myeloid cell leukemia 1.
Topics: Apoptosis; Benzofurans; Least-Squares Analysis; Molecular Docking Simulation; Molecular Dynamics Simulation; Myeloid Cell Leukemia Sequence 1 Protein; Quantitative Structure-Activity Relationship; Reproducibility of Results; Thiophenes | 2019 |
Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors.
Topics: Benzofurans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Isoenzymes; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfonic Acids; Thiophenes | 2019 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.
Topics: Antineoplastic Agents; Benzofurans; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Phosphoric Diester Hydrolases; Pyrophosphatases; Structure-Activity Relationship; Sulfonic Acids; Thiophenes; Tumor Cells, Cultured | 2020 |