benzoporphyrin-d has been researched along with motexafin-lutetium* in 2 studies
2 other study(ies) available for benzoporphyrin-d and motexafin-lutetium
| Article | Year |
|---|---|
Systemic application of photosensitizers in the chick chorioallantoic membrane (CAM) model: photodynamic response of CAM vessels and 5-aminolevulinic acid uptake kinetics by transplantable tumors.
The aim of this study is to modify the chick chorioallantoic membrane (CAM) model into a whole-animal tumor model for photodynamic therapy (PDT). By using intraperitoneal (i.p.) photosensitizer injection of the chick embryo, use of the CAM for PDT has been extended to include systemic delivery as well as topical application of photosensitizers. The model has been tested for its capability to mimic an animal tumor model and to serve for PDT studies by measuring drug fluorescence and PDT-induced effects. Three second-generation photosensitizers have been tested for their ability to produce photodynamic response in the chick embryo/CAM system when delivered by i.p. injection: 5-aminolevulinic acid (ALA), benzoporphyrin derivative monoacid ring A (BPD-MA), and Lutetium-texaphyrin (Lu-Tex). Exposure of the CAM vasculature to the appropriate laser light results in light-dose-dependent vascular damage with all three compounds. Localization of ALA following i.p. injections in embryos, whose CAMs have been implanted with rat ovarian cancer cells to produce nodules, is determined in real time by fluorescence of the photoactive metabolite protoporphyrin IX (PpIX). Dose-dependent fluorescence in the normal CAM vasculature and the tumor implants confirms the uptake of ALA from the peritoneum, systemic circulation of the drug, and its conversion to PpIX. Topics: Allantois; Aminolevulinic Acid; Animals; Biological Transport; Carcinoma, Squamous Cell; Cell Division; Chick Embryo; Chorion; Female; Kinetics; Metalloporphyrins; Ovarian Neoplasms; Photosensitizing Agents; Porphyrins; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1999 |
In vitro and in vivo comparison of argon-pumped and diode lasers for photodynamic therapy using second-generation photosensitizers.
Three prototype microchannel-cooled stacked diode array lasers were compared with the currently used conventional argon ion laser-pumped tunable dye lasers for suitability as light sources in photodynamic therapy (PDT) treatment.. The PDT response of Chinese hamster ovary (CHO-K1) cells in culture and SMT-F tumor bearing mice treated with chloro-aluminum sulfonated phthalocyanin (CASPc), benzoporphyrin derivative mono-acid (BPD-MA), and lutetium texaphyrin (Lutex) was determined using each laser light source. Survival of the CHO cells was measured using a cloning assay. Tumor regression/eradication was used to assess response in the mice.. Both sources of laser light produced comparable PDT responses in the two systems tested.. It would be possible to replace the currently used argon ion laser-pumped dye laser systems with the diode lasers tested. Topics: Animals; Cell Line; Cricetinae; Drug Screening Assays, Antitumor; Female; In Vitro Techniques; Indoles; Laser Therapy; Lutetium; Metalloporphyrins; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Organometallic Compounds; Ovary; Photochemotherapy; Photosensitizing Agents; Porphyrins | 1998 |