benzonidazole has been researched along with nifurtimox in 253 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (16.60) | 18.7374 |
| 1990's | 20 (7.91) | 18.2507 |
| 2000's | 55 (21.74) | 29.6817 |
| 2010's | 118 (46.64) | 24.3611 |
| 2020's | 18 (7.11) | 2.80 |
| Authors | Studies |
|---|---|
| Davioud-Charvet, E; Landry, V; Maes, L; Millet, R; Sergheraert, C | 1 |
| Baliani, A; Barrett, MP; Brun, R; Bueno, GJ; Gilbert, IH; Stewart, ML; Yardley, V | 1 |
| Arán, VJ; Escario, JA; Gómez-Barrio, A; Marrero-Ponce, Y; Meneses-Marcel, A; Montero-Torres, A; Nogal, JJ; Rolón, M; Torrens, F; Vega, MC | 1 |
| Boiani, L; Boiani, M; Cerecetto, H; Denicola, A; Gómez-Barrio, A; Gonzalez, M; Nakayama, H; Rojas de Arias, A; Rolan, M; Sanabria, L; Serna, E; Torres de Ortiz, S; Vega, C; Vera de Bilbao, N; Yaluff, G | 1 |
| Aguirre, G; Boiani, L; Boiani, M; Castro, A; Cerecetto, H; Ferreira, A; González, M; Hernández, P; Maio, RD; Merlino, A; Porcal, W | 1 |
| Aguirre, G; Batista, AA; Beraldo, H; Cerecetto, H; Ferreira, AM; González, M; Hernández, P; Mangrich, AS; Pérez-Rebolledo, A; Speziali, NL; Teixeira, LR | 1 |
| Aguirre, G; Basombrío, MA; Boiani, L; Boiani, M; Campillo, NE; Castro, A; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; Davies, C; González, M; Hernández, P; Krauth-Siegel, RL; Paez, JA; Porcal, W | 1 |
| Armstrong, V; Ciudad, K; Ferreira, J; Kemmerling, U; Maya, JD; Morello, A; Orellana, M; Salas, C; Tapia, RA | 1 |
| Aguirre, G; Boiani, L; Cerecetto, H; García, B; González, M; Lavaggi, ML; Orelli, L | 1 |
| Arredondo, C; Basombrío, MA; Boiani, L; Boiani, M; Cerecetto, H; Davies, C; Gerpe, A; González, M; Merlino, A; Pacheco, JP; Porcal, W | 1 |
| Boiani, L; Boiani, M; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; Ferreira, A; González, M; Hernández, P; Olea-Azar, C; Porcal, W | 1 |
| Aguirre, G; Bertinaria, M; Boiani, L; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; González, M; Guglielmo, S | 1 |
| Araújo, MH; de Assis Souza, M; de Castro, MC; Donnici, CL; Leite, AC; Moreira, DR; Oliveira, HS; Pereira, VR | 1 |
| Bolognesi, ML; Cavalli, A | 1 |
| Boiani, L; Boiani, M; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; González, M; Hernández, P; Merlino, A | 1 |
| Benitez, D; Boiani, L; Castro, D; Cerecetto, H; Gil, C; González, M; Hernández, P; Merlino, A; Olea-Azar, C; Porcal, W | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Aponte, JC; Arevalo, J; Bustamante, JM; Castillo, D; Estevez, Y; Franzblau, SG; Gilman, RH; Gonzalez, G; Hammond, GB; Málaga, E; Pauli, GF; Quiliano, M; Sauvain, M; Tarleton, RL; Vaisberg, AJ; Verástegui, M; Wang, Y; Zimic, M | 1 |
| Fairlamb, AH; Oza, SL; Patterson, S; Read, KD; Sokolova, AY; Wyllie, S | 1 |
| Docampo, R; Kaur, G; King-Keller, S; Li, M; Smith, A; Wang, B; Yang, X; Zheng, S | 1 |
| Aldana, I; Benitez, D; Boiani, L; Cabrera, M; Cerecetto, H; Di Maio, R; Ferreira, ME; González, M; Hernández, P; Lavaggi, ML; López de Ceráin, A; Monge, A; Moreno, E; Pérez-Silanes, S; Serna, E; Solano, B; Torres, E; Torres, S; Vera de Bilbao, N; Yaluff, G | 1 |
| Bloomer, WD; Brun, R; Kaiser, M; McKenzie, C; Papadopoulou, MV; Prasittichai, C; Torreele, E; Trunz, BB; Wilkinson, SR | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; McKenzie, C; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gálvez, J; Gómez-Barrio, A; Marrero-Ponce, Y; Montero-Torres, A; Rolón, M; Vega, MC | 1 |
| Costa, SP; da Rocha, LF; de Melo, CM; de Oliveira Filho, GB; de Simone, CA; Ferreira, RS; Fradico, JR; Guimarães, ET; Hernandes, MZ; Leite, AC; Meira, CS; Moreira, DR; Pereira, VR; Rabello, MM; Soares, MB; Srivastava, RM | 1 |
| Chattopadhyaya, J; Dixit, SS; Földesi, A; Upadhayaya, RS | 1 |
| Berra, CM; Bosch, RV; Ferreira, AK; Ishii, M; Jorge, SD; Maria, DA; Mesquita Pasqualoto, KF; Palace-Berl, F; Tavares, LC | 1 |
| de Sá Bortolozzo, L; Ferreira, AK; Jorge, SD; Lindoso, JÂ; Maria, DA; Palace-Berl, F; Pasqualoto, KF; Tavares, LC; Zorzi, RR | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Kouznetsov, VV; Rojas Ruiz, FA | 1 |
| Brelaz de Castro, MC; da Silva, AC; de Oliveira, AD; de Simone, CA; dos Santos, TA; Ferreira, RS; Leite, AC; Magalhaes Moreira, DR; Pereira, VR; Teixeira de Moraes Gomes, PA; Villela, FS | 1 |
| Álvarez, G; Arias Rivas, CE; Cerecetto, H; Chorilli, M; Cuchilla, K; Echeverría, GA; Escobar, P; Gabay, M; González, M; Leal, SM; Márquez, P; Piro, OE; Serna, E; Torres, S; Varela, J; Vera de Bilbao, NI; Yaluff, G | 1 |
| Ariën, KK; Augustyns, K; Cos, P; Dirié, B; Heeres, J; Joossens, J; Lewi, PJ; Lyssens, S; Maes, L; Michiels, J; Van der Veken, P; Vanham, G; Venkatraj, M | 1 |
| Bautista, JL; Cabrera-Bravo, M; Guevara-Gómez, Y; Hernández-Luis, F; Martinez, CM; Moreno-Rodríguez, A; Pérez-Campos, E; Pina-Canseco, S; Salazar-Schettino, PM; Torrens, H; Torres, MB | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Aguilar-Suárez, R; Correa-Basurto, J; Galindo-Sevilla, N; Hernández-Luis, F; Márquez-Navarro, A; Mendoza-Martínez, C; Montero-Cortes, MD; Nieto-Meneses, R; Nogueda-Torres, B; Rodriguez-Lezama, A; Rojas-Rojas, Á; Suárez-Contreras, E | 1 |
| de Azevedo, RA; Ferreira, AK; Jorge, SD; Palace-Berl, F; Pasqualoto, KF; Silva, MN; Tavares, LC; Teixeira, SF; Zingales, B; Zorzi, RR | 1 |
| Bastos, TM; Cardoso, MV; Castro, MC; Espíndola, JW; Ferreira, RS; Filho, GB; Leite, AC; Moreira, DR; Murta, SM; Oliveira E Silva, DA; Pereira, VR; Romanha, AJ; Sales Junior, PA; Simone, CA; Soares, MB; Villela, FS | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E | 1 |
| Arbillaga, L; Azqueta, A; Cerecetto, H; González, M; Moreno-Viguri, E; Pérez-Silanes, S; Torres, E; Varela, J | 1 |
| Bosc, D; Cojean, S; Dubois, J; Franco, CH; Freitas-Junior, LH; Grellier, P; Loiseau, PM; Moraes, CB; Mouray, E | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR | 2 |
| Favaro, DC; Ferreira, EI; Franco, CH; Freitas-Junior, LH; Moraes, CB; Silva, FT | 1 |
| Azqueta, A; Cirauqui, N; Jimenez-Lopez, M; Jiménez-Montes, C; López de Ceráin, A; Marín, C; Martín-Escolano, R; Martin-Montes, A; Moreno-Viguri, E; Pérez-Silanes, S; Sánchez-Moreno, M; Santivañez-Veliz, M; Zamora Ledesma, S | 1 |
| Agusti, R; Bocanegra-Garcia, V; Garcia-Perez, C; Kashif, M; Lara-Ramirez, EE; López-Cedillo, JC; Nogueda-Torres, B; Rivera, G; Uhrig, ML | 1 |
| Campillo, NE; Cerecetto, H; Escario, JA; Fonseca-Berzal, C; Gomez-Barrio, A; González, M; Gonzalez-Naranjo, P; Guerra, A; Lavaggi, ML; Merlino, A; Páez, JA; Paniagua-Solis, J; Varela, J; Yaluf, G | 1 |
| Argüello-Garcia, R; Barbosa-Cabrera, E; Chan-Bacab, MJ; Colín-Lozano, B; Hernández-Núñez, E; León-Rivera, I; López-Guerrero, V; Moo-Puc, R; Navarrete-Vázquez, G; Ortega-Morales, BO; Scior, T | 1 |
| González-Chávez, Z; Hernández-Luis, F; Jasso-Chávez, R; Melchor-Doncel de la Torre, S; Nieto-Meneses, R; Saavedra, E; Vázquez, C; Yépez-Mulia, L | 1 |
| Augustyns, K; Caljon, G; Heeres, J; Joossens, J; Lewi, PJ; Maes, L; Salado, IG; Van der Veken, P; Venkatraj, M | 1 |
| Bury, M; da Silva Neto, AL; Franco, CH; Moraes, CB; Murayama, JS; Nunes, SL; Palace-Berl, F; Pasqualoto, KFM; Silva, MN; Tavares, LC; Zingales, B | 1 |
| Batista, DDGJ; da Silva, CF; da Silva, PB; Ferreira de Almeida Fiuza, L; Krishna Reddy, TR; Nefertiti Silva da Gama, A; Peres, RB; Simões-Silva, MR; Soeiro, MNC | 1 |
| Batista, MM; Corcoran, O; de Almeida Fiuza, LF; de Nazaré Correia Soeiro, M; Peres, RB; Reddy, TRK; Silva, PB; Ullah, AI | 1 |
| Agusti, R; Ashfaq, M; Chacón-Vargas, KF; Kashif, M; López-Cedillo, JC; Nogueda-Torres, B; Paz-González, AD; Peralta-Cruz, J; Ramírez-Moreno, E; Reyes-Arellano, A; Rivera, G; Uhrig, ML | 1 |
| Cantizani, J; Cogo, J; Corrêa, AG; Cotillo, I; Filho, BPD; Martín, JJ; Nakamura, CV; Sangi, DP; Ueda-Nakamura, T | 1 |
| Alonso, VL; Escalante, AM; Furlan, RLE; García, P; Serra, E | 1 |
| Azas, N; Basmaciyan, L; Belle Mbou, V; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, É; Casanova, M; Castera-Ducros, C; Cohen, A; Courtioux, B; Fairlamb, AH; Fersing, C; Hutter, S; Laget, M; Milne, R; Pedron, J; Piednoel, M; Primas, N; Rathelot, P; Since, M; Sournia-Saquet, A; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S | 1 |
| Bresciani, A; Harper, S; Kaiser, M; Nardi, V; Nizi, E; Ontoria, JM; Pace, P; Paonessa, G; Ponzi, S; Summa, V | 1 |
| Azas, N; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, É; Brossas, JY; Castera-Ducros, C; Corvaisier, S; Courtioux, B; Destere, A; Fairlamb, AH; Fersing, C; Hutter, S; Malzert-Fréon, A; Mazier, D; Paoli-Lombardo, R; Paris, L; Pedron, J; Pinault, E; Primas, N; Rathelot, P; Seguy, L; Since, M; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S | 1 |
| Avery, VM; Charman, SA; Chatelain, E; Cornwall, S; Denny, WA; Francisco, AF; Keenan, M; Kelly, JM; Marshall, AJ; O'Connor, PD; Perez, CJ; Read, KD; Riley, J; Sykes, ML; Thompson, AM; Thompson, RCA; White, KL; Zulfiqar, B | 1 |
| Domínguez-Díaz, LR; Eugenia Ochoa, M; Farfán, N; Morales-Chamorro, M; Moreno-Rodríguez, A; Pérez-Campos, E; Santillan, R; Soto-Castro, D; Yépez-Mulia, L | 1 |
| Ndarathi, CM | 1 |
| Andrade, SG; Freitas, LA; Peyrol, S; Pimentel, AR; Sadigursky, M | 1 |
| Barbieri, GP; Gorla, NB; Larripa, IB; Ledesma, OS | 1 |
| Gallerano, RH; Marr, JJ; Sosa, RR | 1 |
| Cunha Neto, E; Rizzo, LV; Silva, R; Teixeira, AR | 1 |
| Cunha Neto, E; Rizzo, LV; Santana, JM; Silva, R; Teixeira, AR | 1 |
| Alves, MJ; Augusto, O; Brener, Z; Colli, W; Tsuhako, MH | 1 |
| Lazcano, F; Passalacqua, W; Thambo, S; Van Cauwelaert, R | 1 |
| Aldunate, J; Letelier, ME; Moncada, C; Morello, A; Repetto, Y | 1 |
| Goijman, SG; Stoppani, AO | 2 |
| Dubin, M; Goijman, SG; Stoppani, AO | 2 |
| Cazzulo, JJ; Gonzalez, NS | 1 |
| Bernacchi, AS; Carbone, M; Castro, JA; de Castro, CR; de Toranzo, EG | 1 |
| Hof, H | 1 |
| Moreno, SN | 1 |
| Docampo, R; Moreno, SN | 1 |
| Neal, RA; van Bueren, J | 1 |
| Brener, Z; Filardi, LS | 1 |
| Moya, PR; Trombotto, GT | 1 |
| Castro, JA; Diaz de Toranzo, EG | 1 |
| Aldunate, J; Letelier, ME; Morello, A; Repetto, Y | 1 |
| Gutteridge, WE | 1 |
| de Melo, ME; Ferreira, LC; Ferreira, RC; Moraes Júnior, MA | 1 |
| Ferreira, LC; Ferreira, RC; Schwarz, U | 1 |
| Aguilar, E; Castro, JA; de Arranz, CK; de Toranzo, EG | 1 |
| Ferreira, LC; Ferreira, RC | 1 |
| Nagel, R | 1 |
| Gorla, NB | 1 |
| Aguilar, EG; Castro, JA; de Toranzo, EG; Koldobsky, C | 1 |
| Bernacchi, AS; Castro, JA; de Castro, CR; de Toranzo, EG | 1 |
| Aguilar, EG; Castro, JA; de Arranz, CK; de Toranzo, EG | 1 |
| Frasch, AC; Goijman, SG; Stoppani, AO | 3 |
| Apt, W | 2 |
| Andrade, SG; Magalhães, JB; Pontes, AL | 1 |
| Gallerano, RH; Meirovich, CI; Montrull, HL; Sosa, RR | 1 |
| Castro, GD; Castro, JA | 1 |
| Castro, JA; Gorla, NB | 1 |
| Docampo, R; Moreno, SN; Stoppani, AO | 1 |
| Cabeza Meckert, P; Chambó, JG; Gelpi, R; Laguens, RP | 1 |
| Castro, JA; de Toranzo, EG; Masana, M | 1 |
| Barrett, PA; Beveridge, E; Bull, D; Caldwell, IC; Islip, PJ; Neal, RA; Woods, NC | 1 |
| Abitbol, H | 1 |
| Rassi, A | 1 |
| Barousse, AP; Cabrera, H; Laplumé, H | 1 |
| Calixto, MA; Teixeira, AR; Teixeira, ML | 1 |
| de Castro, SL | 1 |
| Cancado, JR; Galvao, LM; Gazzinelli, RT; Krautz, G; Krettli, AU; Lima, PC; Scharfstein, J | 1 |
| Kirchhoff, LV | 1 |
| Agosin, M; Maya, JD; Morello, A; Opazo, E; Repetto, Y | 1 |
| Agosín, M; Gaule, C; Maya, JD; Morello, A; Ojeda, JM; Repetto, Y; Tellez, R | 1 |
| Billaut-Mulot, O; Fernandez-Gomez, R; Ouaissi, A | 1 |
| Barnabé, C; Carrière, V; Laurent, JP; Noël, S; Oury, B; Quesney, V; Revollo, S; Tibayrenc, M | 1 |
| Brener, Z; Gazzinelli, RT; Murta, SM; Romanha, AJ | 1 |
| Moreno, SN; Yan, W | 1 |
| Allaoui, A; François, C; Guilvard, E; Ouaissi, A; Zemzoumi, K | 1 |
| Arán, VJ; Cerecetto, H; Di Maio, R; Gómez Barrio, A; Muelas, S; Ochoa, C; Pérez, E; Seoane, G | 1 |
| Segura, EL; Sosa Estani, S | 1 |
| Amato Neto, V | 1 |
| Blanco, SB; Chuit, R; Cura, EN; Flores, I; Garbarino, G; Gürtler, RE; Segura, EL; Tulián, L; Villalonga, JF | 1 |
| de Lima, AP; Gauthier, F; Juliano, L; Lalmanach, G; Scharfstein, J; Schmitz, V; Vannier-Santos, MA; Yong, V | 1 |
| Gómez-Barrio, A; Muelas-Serrano, S; Nogal-Ruiz, JJ | 1 |
| Castro, JA | 1 |
| Anacleto, C; dos Santos, WG; Moreira, ES; Murta, SM; Nirdé, P; Romanha, AJ | 1 |
| de Castro, SL; Rodriques Coura, J | 1 |
| Cerecetto, H; González, M | 1 |
| Escario, JA; Fernández-Portillo, C; Gómez-Barrio, A; Le-Senne, A; Muelas-Serrano, S | 1 |
| Cortés, MJ; Cuellar, MA; Diego Maya, J; Morello, A; Preite, MD; Salas, C | 1 |
| Gallerano, RR; Sosa, RR | 1 |
| Baeza, I; Chena, MA; Elizondo, S; Nogueda, B; Rodríguez-Páez, L; Wong, C | 2 |
| Ferreira, J; Maya, JD; Morello, A; Pabón, A; Pavani, M; Pino, L; Repetto, Y; Rodríguez, A | 1 |
| Afonso, LC; Bahia, MT; Chiari, E; de Lana, M; Guedes, PM; Machado-Coelho, GL; Tafuri, WL; Urbina, JA; Veloso, VM | 1 |
| Faundez, M; Ferreira, J; Letelier, P; López, R; Maya, JD; Morello, A; Ortiz, C; Pavani, M; Pino, L; Seguel, C | 1 |
| Escario, JA; Gómez-Barrio, A; Martínez-Fernández, AR; Rolón, M; Vega, C | 1 |
| Reyes, PA; Vallejo, M | 1 |
| Althabe, F; Belizan, JM; Rubinstein, A; Sosa-Estani, S | 1 |
| Avila, AR; Bruna-Romero, O; Campos, FF; de Oliveira, RC; Goldenberg, S; Krieger, MA; Montenegro, LR; Murta, SM; Muto, NH; Nirdé, P; Nunes, LR; Probst, CM; Romanha, AJ | 1 |
| Escario, JA; Gómez-Barrio, A; Rolón, M; Vega, C | 1 |
| Weir, E | 1 |
| Cassels, BK; Faúndez, M; Ferreira, A; Ferreira, J; Galanti, N; Iturriaga-Vásquez, P; Maya, JD; Morello, A | 1 |
| Bartel, LC; Castro, JA; de Mecca, MM | 2 |
| Horn, D; Kelly, JM; Prathalingham, SR; Wilkinson, SR | 1 |
| Aguirre-Alvarado, C; Baeza, I; Nogueda, B; Rodríguez-Páez, L; Wong, C; Zaragoza-Martínez, F | 1 |
| Doyle, PS; Engel, JC; McKerrow, JH; Zhou, YM | 1 |
| Jannin, J; Villa, L | 1 |
| El Masri, M; Karcz, DA; Lennox, HA; Tales, H | 1 |
| Cheeseman, I; Horn, D; Kelly, JM; Taylor, MC; Wilkinson, SR | 1 |
| de Souza, JL; Ianni, BM; Mady, C | 1 |
| A, IZ; B, WA; G, IH; H, IN; H, MT; L, MI; M, LJ; P, JS; V, AM; V, PM | 1 |
| Bartel, LC; Castro, CR; Castro, JA; Mecca, MM | 1 |
| Altcheh, J; Della Védova, CO; Garcia-Bournissen, F; Giglio, N; Koren, G; Mastrantonio, G | 1 |
| Develoux, M; Le Loup, G; Lescure, FX; Pialoux, G | 1 |
| Campos, FM; Liarte, DB; Mortara, RA; Murta, SM; Romanha, AJ | 1 |
| Escanilla, S; Faúndez, M; Ferreira, A; Ferreira, J; Kemmerling, U; Klein, S; Lee-Liu, D; López-Muñoz, R; Maya, JD; Morello, A; Orellana, M; Torres, G | 1 |
| Bowling, J; Walter, EA | 1 |
| Ibrahim, K; Le Loup, G; Malvy, D | 1 |
| Bartel, LC; Bietto, FM; Castro, JA; de Castro, CR; Montalto de Mecca, M | 1 |
| Machado, FS; Tanowitz, HB; Teixeira, MM | 1 |
| Croft, SL; Escobar, P; Hernández, IP; Luna, KP; Rueda, CM; Zorro, MM | 1 |
| Bocchi, EA; Issa, VS | 1 |
| Altcheh, J; Biancardi, M; Freilij, H; Liesenfeld, O; Mayer, JP; Weinke, T | 1 |
| Alsford, S; Baker, N; Horn, D | 1 |
| Ferreira, J; Kemmerling, U; López-Muñoz, R; Maya, JD; Morello, A; Orellana, M | 1 |
| Arias, E; Bizai, ML; Bottasso, O; del Barco, M; Denner, S; Diez, C; Fabbro, DL; Mancipar, I; Marcipar, I; Mendicino, D; Olivera, V; Streiger, M | 1 |
| Guedes, PM; Gutierrez, FR; Silva, GK; Silva, JS | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Bern, C | 1 |
| Salomon, CJ | 1 |
| Levy, MZ; Manne, J; Reich, MR; Snively, CS | 1 |
| Albajar Viñas, P; Carrilero, B; Murcia, L; Segovia, M | 1 |
| Marcondes de Rezende, J; Rassi, A | 1 |
| Galimberti, RL; Maqueda, MG; Piñero, MC; Riganti, J; Volonteri, VI | 1 |
| Hall, BS; Meredith, EL; Wilkinson, SR | 1 |
| Carlier, Y; Cencig, S; Coltel, N; Truyens, C | 1 |
| Bandyopadhyay, D; Banik, BK; Nogueda-Torres, B; Rivera, G; Samano, S; Sanchez-Torres, LE; Villalobos-Rocha, JC | 1 |
| Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J | 1 |
| Espinoza, B; Martínez, I; Martínez-Hernández, F; Nogueda, B | 1 |
| Albajar-Viñas, P; Díaz-Menéndez, M; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Sojo-Dorado, J | 1 |
| Altcheh, J; García-Bournissen, F; Marsón, ME; Mastrantonio, GE; Padró, JM; Reta, M | 1 |
| Arias, E; Bizai, ML; Denner, S; Fabbro, D; Olivera, V; Pravia, C; Ruiz, AM; Velazquez, E | 1 |
| Ashworth, R; Bloomer, W; Buchanan-Kilbey, G; Djumpah, J; Hu, L; Papadopoulou, MV; Wilkinson, SR | 1 |
| Aguilera-Venegas, B; Arán, VJ; Olea-Azar, C; Speisky, H | 1 |
| Alarcón de Noya, B; Araujo-Jorge, T; Gascon, J; Grijalva, MJ; Guhl, F; López, MC; Ramsey, JM; Ribeiro, I; Schijman, AG; Sosa-Estani, S; Torrico, F; Viotti, R | 1 |
| de Araujo, AC; De Mattos, JC; García-Huertas, PA; Hamedt, AL; Ortiz, IC; Rodríguez-Gazquez, MA; Sáenz, J; Triana-Chávez, O | 1 |
| Campos, MC; Kelly, JM; Leon, LL; Taylor, MC | 1 |
| Castillo, C; Droguett, D; Duaso, J; Galanti, N; Kemmerling, U; Liempi, A; López-Muñoz, R; Maya, JD; Rojo, G | 1 |
| Bustamante, JM; Tarleton, RL | 1 |
| Galanti, N; Jimenez, V; Kemmerling, U; Maya, JD; Paredes, R; Sosa, MA | 1 |
| Basombrio, MA; Davies, C; Dey, N; Garg, NJ; Negrette, OS; Parada, LA | 1 |
| Aznar, C; Bisio, M; Blanchet, D; Brenière, SF; Demar-Pierre, M; Djossou, F; Mayence, C; Schijman, AG; Simon, S; Véron, V | 1 |
| Angheben, A; Anselmi, M; Bisoffi, Z; Buonfrate, D; Chiampan, A; Gobbi, F; Mainardi, P; Marocco, S; Postiglione, C; Repetto, E; Tais, S | 1 |
| Alonso-Padilla, J; Bardera, AI; Cantizani, J; Cotillo, I; Martín, JJ; Peña, I; Presa, JL; Rodriguez, A | 1 |
| Califano, AN; Echevarria, RN; Padró, JM; Pellegrino Vidal, RB; Reta, MR | 1 |
| Baeza, I; Meza-Toledo, S; Nogueda-Torres, B; Serna, M; Wong, C; Wong-Baeza, C | 1 |
| Manne-Goehler, J; Reich, MR; Wirtz, VJ | 1 |
| Morel, CM; Thota, S | 1 |
| Alba Soto, CD; Curto, MLA; Lammel, EM; Miranda, CG; Schijman, AG; Solana, ME | 1 |
| Bhattacharyya, T; Burleigh, BA; Costales, JA; Garcia-Perez, J; Kotton, CN; Llewellyn, MS; Messenger, LA; Zurita-Leal, AC | 1 |
| Avezum, Á; Cordeiro Mattos, AJ; Oliveira, GB | 1 |
| Ciapponi, A; Comandé, D; Cuesta, CB; Hicks, E; Roberts, KN; Sguassero, Y; Sosa-Estani, S | 1 |
| Angheben, A; Aprili, G; Bisoffi, Z; Boix, L; Buonfrate, D; Gandini, G; Gobbi, F; Pupella, S | 1 |
| Díaz, ML; Escobar, P; González Rugeles, CI; Leal, S; López-Muñoz, R; Mantilla, JC; Molina-Berríos, A; Solari, A | 1 |
| Bermudez, J; Davies, C; Palma, S; Real, JP; Simonazzi, A | 1 |
| Briceno, L; Mosca, W | 1 |
| Moreno-Viguri, E; Paucar, R; Pérez-Silanes, S | 1 |
| Brunoro, GV; Caminha, MA; de Moura, KC; Faça, VM; Ferreira, AT; Menna-Barreto, RF; Perales, J; Trugilho, M; Valente, RH | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Alarcón de Noya, B; Castro, J; Colmenares, C; Díaz-Bello, Z; Gutiérrez, H; Naranjo, L; Noya, O; Noya-Alarcón, O; Ossenkopp, J; Quinci, G; Ruiz-Guevara, R; Suárez, JA; Torres, J | 1 |
| Muñoz Casas Del Valle, P | 1 |
| Abi-Saab Arrieche, M; Aguilar, NG; Alves, RV; Chaves, GC; Mechali, D; Reis, PO; Ribeiro, I; Rode, J; Stobbaerts, E | 1 |
| Alpern, JD; Lopez-Velez, R; Stauffer, WM | 1 |
| Agüero, F; Alvarez, VE; Cazzulo, JJ; Karpiak, J; Landaburu, LU; Madauss, KP; Salas-Sarduy, E | 1 |
| Zingales, B | 1 |
| Carneiro, CM; Corrêa-Oliveira, R; Fonseca Murta, SM; Molina, I; Sales Junior, PA; Salvador, F; Sánchez-Montalvá, A | 1 |
| Altcheh, J; Bisio, M; García-Bournissen, F; Gulin, JEN; Rocco, DM; Solana, ME | 1 |
| Bastos, MM; Batista, DDGJ; Bianco, MDCAD; Boechat, N; da Gama, ANS; da Silva, CF; da Silva, PB; de Oliveira, AP; Fontes, FV; Hoelz, LVB; Leite, DI; Peres, RB; Soeiro, MNC; Villar, JDF | 1 |
| Chamorro-Tojeiro, S; Crespillo-Andújar, C; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA | 1 |
| Batista, R; Loebe, M; Macias, AE; Magarakis, M; Reis, V; Salerno, TA; Tompkins, BA | 1 |
| Borchardt, RA; Tzizik, DM | 1 |
| Akutsu, Y; Doi, M; Furukawa, K; Takagi, Y | 1 |
| Abril, M; Alonso-Padilla, J; Barreira, F; Bottazzi, ME; Cortés-Serra, N; Gascón, J; Hotez, PJ; Pinazo, MJ; Sosa-Estani, S | 1 |
| Assíria, T; Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Ribeiro, I; WonDollinger, RS | 1 |
| Custodio Leite, TO | 1 |
| Boechat, N; Conde, TR; de Carvalho, AS; de Castro, SL; Lemos, RC; Pitombeira, MCS; Quaresma, BMC; Salomão, K; Von Trompowsky, ACM; Zamith, HPDS | 1 |
| Arrúa, EC; Bedogni, GR; Okulik, NB; Salomon, CJ; Seremeta, KP | 1 |
| Castellanos Domínguez, YZ; Cucunubá, ZM; Hernández, Y; Herrera, VM; Pérez Carreño, JG; Prado, NG; Váquiro Herrera, E; Vásquez, SM; Villar, JC | 1 |
| Kratz, JM | 1 |
| Bronzon da Costa, CM; Bulhões Portapilla, G; de Albuquerque, S; Ferreira Anchieta, N; Goulart, A; Leite Braga, GÚ; Pereira, LM; Sampaio Oliveira, PA; Voltarelli Providello, M; Wainwright, M | 1 |
| Muñoz-Calderon, A; Schijman, AG; Sulleiro, E | 1 |
| Aviles, AS; Carneiro, CM; Cunha, LM; da Silva Fonseca, K; de Abreu Vieira, PM; Molina, I; Perin, L | 1 |
| Chappuis, F; Jackson, Y; Wyssa, B | 1 |
| Alonso-Padilla, J; Cortes-Serra, N; Fernandez-Becerra, C; Gascon, J; Losada-Galvan, I; Pinazo, MJ | 1 |
| Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC | 1 |
| Cunha-Neto, E; Kalil, J; Moore, CE; Nascimento, MS; Pandey, RP; Raj, VS | 1 |
| Acosta, N; Bobadilla, C; Escobar, P; Fernández, I; López, E; Ramírez, A; Yaluff, G | 1 |
| Gonzalez Garay, AG; Martinez Garcia, M; Reyes, PP; Vallejo, M | 1 |
| Arias, E; Bizai, ML; Bottasso, O; Fabbro, D; Marcipar, I; Olivera, V; Suasnabar, S | 1 |
| Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Mota, SLA; Pereira, DE | 1 |
| Cardona-Castro, N; García-Huertas, P | 1 |
| Alvedro, A; Bhattacharyya, T; Cardinal, MV; Enriquez, GF; Freilij, H; Gilleman, Q; Gürtler, RE; Macchiaverna, NP; Martinez de Salazar, P; Mertens, P; Miles, MA; Molina, I; Murphy, N | 1 |
| Bartholomeu, DC; Burle-Caldas, GA; Murta, SMF; Reis-Cunha, JL; Resende, DM; Ribeiro, JM; Santi, AMM; Santos, IFM; Silva, PA; Teixeira, SMR | 1 |
| Altcheh, J; Ballering, G; Bochoeyer, A; Chatelain, E; Falk, N; Freilij, H; Garcia Bournissen, F; Goldsman, A; González, NL; Grippo, M; Jurado, L; Moroni, S; Moscatelli, G | 1 |
| Baeza, I; Barrera-Aveleida, G; Galarce-Sosa, I; Gómez-Manzo, S; Meza-Toledo, S; Nevárez-Lechuga, I; Nogueda-Torres, B; Reséndiz-Mora, A; Santiago-Hernández, JC; Sotelo-Rodríguez, A; Wong-Baeza, C; Wong-Baeza, I | 1 |
47 review(s) available for benzonidazole and nifurtimox
| Article | Year |
|---|---|
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
Topics: Animals; Antiprotozoal Agents; Drug Discovery; Humans; Leishmania; Ligands; Rare Diseases; Tropical Medicine; Trypanosoma | 2009 |
Free radical metabolism of antiparasitic agents.
Topics: Animals; Chemical Phenomena; Chemistry; Free Radicals; Hydrogen Peroxide; Macromolecular Substances; Metronidazole; Nifurtimox; Niridazole; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Parasitic Diseases; Schistosoma mansoni; Superoxides; Tritrichomonas; Trypanosoma cruzi | 1986 |
Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas' disease).
Topics: Chagas Disease; Humans; Latin America; Nifurtimox; Nitrofurans; Nitroimidazoles | 1988 |
[Biochemical bases of the action of anti-chagasic drugs].
Topics: Allopurinol; Animals; Free Radicals; Gentian Violet; Glutathione; Humans; Nifurtimox; Nitroimidazoles; Oxidation-Reduction; Trypanocidal Agents; Trypanosoma cruzi | 1988 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi.
Topics: Animals; Anti-Bacterial Agents; Azoles; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1993 |
Chagas disease. American trypanosomiasis.
Topics: Animals; Chagas Disease; Heart; Humans; Immunocompromised Host; Interferon-gamma; Laboratory Infection; Mice; Nifurtimox; Nitroimidazoles; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi; United States | 1993 |
[Treatment of Trypanosoma cruzi infection in the indeterminate phase: experience and current guidelines in Argentina].
Topics: Adult; Argentina; Chagas Disease; Child; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1999 |
Contributions of toxicology to the problem of Chagas' disease (American Trypanosomiasis)--a year 2000 update.
Topics: Animals; Chagas Disease; Gentian Violet; Humans; Insect Vectors; Nifurtimox; Nitroimidazoles; Toxicology; Trypanocidal Agents | 2000 |
A critical review on Chagas disease chemotherapy.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2002 |
Chemotherapy of Chagas' disease: status and new developments.
Topics: Animals; Chagas Disease; Drug Design; Enzyme Inhibitors; Humans; Nifurtimox; Nitroimidazoles; Phosphoenolpyruvate Carboxykinase (ATP); Reducing Agents; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Humans; Imidazoles; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2005 |
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
Topics: Acute-Phase Reaction; Animals; Chagas Disease; Ergosterol; Host-Parasite Interactions; Humans; Immunologic Factors; Mammals; Nifurtimox; Nitric Oxide; Nitroimidazoles; Purines; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis).
Topics: Animals; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2006 |
An overview of Chagas disease treatment.
Topics: Chagas Disease; Health Services Accessibility; Humans; International Cooperation; Nifurtimox; Nitroimidazoles; Pan American Health Organization; Trypanocidal Agents | 2007 |
Chagas disease: clinical overview and implications for nursing.
Topics: Acute Disease; Animals; Canada; Chagas Disease; Chronic Disease; Emigration and Immigration; Hispanic or Latino; Humans; Immunologic Tests; Incidence; Insect Control; Insect Vectors; Nifurtimox; Nitroimidazoles; Nurse's Role; Prevalence; Primary Prevention; Risk Factors; South America; Travel; Triatoma; Trypanocidal Agents; United States | 2007 |
Benznidazole and Chagas disease: can an old drug be the answer to an old problem?
Topics: Adolescent; Adult; Chagas Disease; Child; Humans; Middle Aged; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2008 |
Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.
Topics: Argentina; Chagas Cardiomyopathy; Chagas Disease; Child; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Recognizing and meeting the challenge of Chagas disease in the USA.
Topics: Chagas Disease; Guidelines as Topic; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States | 2009 |
Current and developing therapeutic agents in the treatment of Chagas disease.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Time Factors; Treatment Outcome; Trypanocidal Agents | 2010 |
Chagas disease: Present status of pathogenic mechanisms and chemotherapy.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Current status of Chagas disease chemotherapy.
Topics: Adult; Animals; Chagas Disease; Child; Clinical Trials as Topic; Drug Administration Schedule; Humans; Latin America; Mice; Myocarditis; Nifurtimox; Nitroimidazoles; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
Antitrypanosomal therapy for chronic Chagas' disease.
Topics: Adult; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Humans; Life Cycle Stages; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
First century of Chagas' disease: an overview on novel approaches to nifurtimox and benzonidazole delivery systems.
Topics: Animals; Chagas Disease; Drug Delivery Systems; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
American trypanosomiasis (Chagas disease).
Topics: Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Immunosuppression and Chagas disease: a management challenge.
Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi | 2013 |
Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.
Topics: Chagas Disease; Drug Design; Humans; Indazoles; NADH, NADPH Oxidoreductases; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Potential new clinical therapies for Chagas disease.
Topics: Chagas Disease; Clinical Trials as Topic; Drug Discovery; Drug Therapy, Combination; Humans; Nifurtimox; Nitroimidazoles; Sterols; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Drug Discovery for Paediatric Chagas Disease.
Topics: Antiparasitic Agents; Chagas Disease; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2018 |
Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Child; Chronic Disease; Cohort Studies; Disease Progression; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Hemagglutination Tests; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Randomized Controlled Trials as Topic; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Xenodiagnosis | 2015 |
Chagas disease and transfusion medicine: a perspective from non-endemic countries.
Topics: Adult; Blood Donors; Blood Safety; Chagas Disease; Donor Selection; Emigration and Immigration; Enzyme-Linked Immunosorbent Assay; Europe; Female; Global Health; Health Services Needs and Demand; Humans; Infant, Newborn; Latin America; Male; Mass Screening; Nifurtimox; Nitroimidazoles; North America; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Transfusion Reaction; Travel; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Current drug therapy and pharmaceutical challenges for Chagas disease.
Topics: Americas; Chagas Disease; Humans; Life Cycle Stages; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
[What is not searched, it is difficult to find: Chagas' disease].
Topics: Chagas Cardiomyopathy; Chagas Disease; Emigrants and Immigrants; Humans; Italy; Neglected Diseases; Nifurtimox; Nitroimidazoles; Prevalence; South America; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Challenges in Chagas Disease Drug Discovery: A Review.
Topics: Chagas Disease; Clinical Trials as Topic; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Real-Time Polymerase Chain Reaction; RNA, Protozoan; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
Topics: Animals; Argentina; Biological Evolution; Chagas Disease; Drug Resistance; Genetic Variation; Genotype; Humans; Nifurtimox; Nitroimidazoles; Serologic Tests; Trypanosoma cruzi | 2018 |
Experimental and Clinical Treatment of Chagas Disease: A Review.
Topics: Animals; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Drug Compounding; Humans; Incidence; Latin America; Nanoparticles; Nifurtimox; Nitroimidazoles; Observational Studies as Topic; Randomized Controlled Trials as Topic; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Cardiac surgery for Chagas disease.
Topics: Cardiac Surgical Procedures; Chagas Cardiomyopathy; Echocardiography; Female; Heart Aneurysm; Heart Ventricles; Humans; Magnetic Resonance Imaging; Middle Aged; Nifurtimox; Nitroimidazoles; Serologic Tests; Stroke Volume; Treatment Outcome; Trypanocidal Agents | 2018 |
Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America.
Topics: Chagas Disease; Health Services Accessibility; Humans; Latin America; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review.
Topics: Chagas Disease; Dosage Forms; Humans; Nanostructures; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2019 |
Drug discovery for chagas disease: A viewpoint.
Topics: Chagas Disease; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Role of nucleic acid amplification assays in monitoring treatment response in chagas disease: Usefulness in clinical trials.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Drug Resistance; Humans; Nifurtimox; Nitroimidazoles; Nucleic Acids; Parasite Load; Real-Time Polymerase Chain Reaction; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis.
Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2020 |
New Approaches for the Treatment of Chagas Disease.
Topics: Animals; Chagas Disease; Drug Repositioning; Humans; Neglected Diseases; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Placebos; Randomized Controlled Trials as Topic; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets.
Topics: Animals; Chagas Disease; Drug Development; Drug Resistance; Humans; Medicine, Traditional; Molecular Targeted Therapy; Nifurtimox; Nitroimidazoles; Plant Preparations; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
4 trial(s) available for benzonidazole and nifurtimox
| Article | Year |
|---|---|
Therapeutic efficacy of allopurinol in patients with chronic Chagas' disease.
Topics: Adult; Allopurinol; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1990 |
[Treatment of Chagas' disease].
Topics: Animals; Cats; Chagas Disease; Clinical Trials as Topic; Cricetinae; Dogs; Guinea Pigs; Humans; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Rats; Trypanocidal Agents; Trypanosoma cruzi | 1985 |
[Allopurinol in the treatment of chronic Chagas' disease].
Topics: Allopurinol; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1985 |
Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial.
Topics: Adult; Aged; Asymptomatic Diseases; Chagas Disease; Colombia; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nifurtimox; Nitroimidazoles; Randomized Controlled Trials as Topic; Therapeutic Equivalency; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
202 other study(ies) available for benzonidazole and nifurtimox
| Article | Year |
|---|---|
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
Topics: Animals; Cell Survival; Humans; Hydrazines; Inhibitory Concentration 50; Leishmania infantum; Macrophages, Peritoneal; Mice; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Tumor Cells, Cultured | 2002 |
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
Topics: Animals; Cell Line; Female; Furaldehyde; Hydrazones; Leishmania donovani; Mice; Nitrofurans; Nucleoside Transport Proteins; Rats; Thiophenes; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2005 |
New ligand-based approach for the discovery of antitrypanosomal compounds.
Topics: Animals; Antiprotozoal Agents; Ligands; Trypanosoma | 2006 |
2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.
Topics: Acute Disease; Animals; Benzimidazoles; Cell Line; Chagas Disease; Cyclic N-Oxides; Leishmania; Macrophages; Mice; Mice, Inbred BALB C; Models, Molecular; Oxidation-Reduction; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.
Topics: Animals; Benzoxazoles; Cell Line; Cell Survival; Humans; Indicators and Reagents; Macrophages; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
4-nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity.
Topics: Acetophenones; Animals; Chelating Agents; Copper; Crystallography, X-Ray; Electrochemistry; Electron Spin Resonance Spectroscopy; Humans; In Vitro Techniques; Macrophages; Magnetic Resonance Spectroscopy; Molecular Structure; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.
Topics: Animals; Antibodies, Protozoan; Benzoxazoles; Cell Line; Chagas Disease; Cysteine Endopeptidases; Female; Glutathione; Humans; Macrophages; Mice; Models, Molecular; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxygen Consumption; Protozoan Proteins; Stereoisomerism; Structure-Activity Relationship; Sulfones; Trypanocidal Agents; Trypanosoma cruzi; Vinyl Compounds | 2007 |
Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.
Topics: Animals; Molecular Structure; Naphthoquinones; Oxidation-Reduction; Stereoisomerism; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi.
Topics: Animals; Antimalarials; Cyclic N-Oxides; Electrons; Inhibitory Concentration 50; Molecular Structure; Phenazines; Quinoxalines; Structure-Activity Relationship; Trypanosoma cruzi | 2008 |
In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Benzoxazoles; Chagas Disease; Disease Models, Animal; Female; Mice; Parasitemia; Treatment Outcome; Trypanosoma cruzi | 2008 |
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.
Topics: Animals; Benzoxazoles; Cysteine Endopeptidases; Glutathione; Hydrazones; Macrophages; Mice; Oxidative Stress; Protozoan Proteins; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.
Topics: Animals; Dose-Response Relationship, Drug; Leishmania; Molecular Structure; Nitrites; Oxadiazoles; Parasitic Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships.
Topics: Animals; Cell Survival; Cells, Cultured; DNA; Hydrazones; Mice; Mice, Inbred BALB C; Plasmids; Ruthenium Compounds; Spleen; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies.
Topics: Animals; Benzimidazoles; Cell Line; Cell Survival; Chagas Disease; Glucose; Leishmania braziliensis; Leishmaniasis; Macrophages; Mice; Mitochondria; Oxidoreductases; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.
Topics: Animals; Benzoxazoles; Inhibitory Concentration 50; Macrophages; Mice; Molecular Structure; Organophosphorus Compounds; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.
Topics: Antiprotozoal Agents; Antitubercular Agents; Cell Line, Tumor; Humans; Mycobacterium tuberculosis; Parasitic Sensitivity Tests; Pyrimidines; Trypanosoma cruzi | 2010 |
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Nifurtimox; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Molecular Structure; Phosphoric Diester Hydrolases; Protozoan Proteins; Trypanosoma cruzi | 2010 |
3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.
Topics: Animals; Chemistry, Pharmaceutical; Cyclic N-Oxides; Drug Design; Electrons; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Mutagenicity Tests; Parasitemia; Quinoxalines; Toxicity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
Topics: Amines; Animals; Cells, Cultured; Chagas Disease; Leishmania donovani; Mice; Nitro Compounds; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2011 |
Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.
Topics: Amides; Animals; Cell Line; Leishmania donovani; Nitro Compounds; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Rats; Structure-Activity Relationship; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2012 |
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug.
Topics: Dose-Response Relationship, Drug; Indazoles; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Topics: Animals; Cell Proliferation; Chagas Disease; Computer Simulation; Cysteine Endopeptidases; Female; Imines; Mice; Mice, Inbred BALB C; Models, Molecular; Protein Binding; Protozoan Proteins; Spleen; Stereoisomerism; Structure-Activity Relationship; Thiazolidines; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
New antiprotozoal agents: their synthesis and biological evaluations.
Topics: Amphotericin B; Antiprotozoal Agents; Cell Line; Cell Survival; Humans; Leishmania infantum; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Quinolines; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2013 |
Ligand-based design, synthesis, and experimental evaluation of novel benzofuroxan derivatives as anti-Trypanosoma cruzi agents.
Topics: Benzoxazoles; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Fibroblasts; Humans; Ligands; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Quantitative Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
5-Nitro-2-furfuriliden derivatives as potential anti-Trypanosoma cruzi agents: design, synthesis, bioactivity evaluation, cytotoxicity and exploratory data analysis.
Topics: Animals; Cell Line; Cell Survival; Cluster Analysis; Drug Design; Humans; Mice; Molecular Dynamics Simulation; Oxadiazoles; Principal Component Analysis; Static Electricity; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.
Topics: Animals; Benzothiazoles; Cell Line; Cell Survival; Leishmania donovani; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2013 |
In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents.
Topics: Aminoquinolines; Animals; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibroblasts; Mice; Molecular Structure; Phenotype; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Topics: Animals; Cell Line; Cells, Cultured; Chagas Disease; Cysteine Proteases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Mice; Mice, Inbred BALB C; Molecular Conformation; Spleen; Structure-Activity Relationship; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity.
Topics: Animals; Drug Stability; Female; Mice; Mice, Inbred BALB C; Mutation; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Parasitic Sensitivity Tests; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense | 2014 |
In vitro antiparasitic activity of new thiosemicarbazones in strains of Trypanosoma cruzi.
Topics: Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Humans; In Vitro Techniques; Molecular Structure; Monocytes; Platelet Activation; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.
Topics: Amides; Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Leishmania donovani; Leishmaniasis, Visceral; Molecular Structure; Monocytes; Platelet Activation; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Leishmania major; Malaria; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium vivax; Quinazolines; Structure-Activity Relationship; Trypanosoma cruzi; Vero Cells | 2015 |
Designing and exploring active N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients.
Topics: Antiprotozoal Agents; Cells, Cultured; Chagas Disease; Dose-Response Relationship, Drug; Drug Design; Fibroblasts; Humans; Hydrazines; Hydrazones; Models, Molecular; Molecular Structure; Nitrofurans; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma cruzi | 2015 |
Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Topics: Crystallography, X-Ray; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Protozoan Proteins; Structure-Activity Relationship; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi | 2015 |
Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity.
Topics: Animals; Cell Survival; Chlorocebus aethiops; Nitrogen; Oxides; Quinoxalines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Imidazoles; Leishmania donovani; Leishmaniasis, Visceral; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Plasmodium falciparum; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis | 2016 |
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.
Topics: Amides; Antiprotozoal Agents; Cell Line; Chagas Disease; Humans; Leishmania; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma | 2016 |
Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues.
Topics: Cell Line, Tumor; Chemistry Techniques, Synthetic; Humans; Hydrazones; Models, Molecular; Molecular Conformation; Nitrofurazone; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
Topics: Acetamides; Animals; Mice; Nitroreductases; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis, African | 2016 |
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
Topics: Animals; Cells, Cultured; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Mannich Bases; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
An in vitro and in vivo evaluation of new potential trans-sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method.
Topics: Animals; Anti-Inflammatory Agents; Antiprotozoal Agents; Drug Repositioning; Glycoproteins; Mice; Neuraminidase; Structure-Activity Relationship; Sulfasalazine; Trypanosoma cruzi | 2017 |
Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties.
Topics: Animals; Cell Proliferation; Dose-Response Relationship, Drug; Fibroblasts; Imidazoles; Macrophages; Mice; Molecular Structure; Neural Networks, Computer; Structure-Activity Relationship; Thiadiazines; Trypanosoma cruzi | 2017 |
Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiprotozoal Agents; Drug Design; Female; Giardia lamblia; Giardiasis; Humans; Leishmania; Mice; Nitro Compounds; Protozoan Infections; Thiazoles; Trichomonas vaginalis; Trypanosoma cruzi | 2017 |
Synthesis and biological evaluation of 2-methyl-1H-benzimidazole-5-carbohydrazides derivatives as modifiers of redox homeostasis of Trypanosoma cruzi.
Topics: Animals; Benzimidazoles; Dose-Response Relationship, Drug; Homeostasis; Hydrazines; Mice; Molecular Structure; Oxidation-Reduction; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Novel triazine dimers with potent antitrypanosomal activity.
Topics: Animals; Antiprotozoal Agents; Cell Proliferation; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Drug Discovery; Fibroblasts; Humans; Leishmania infantum; Male; Mice; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2018 |
Investigating the structure-activity relationships of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds.
Topics: Cell Line; Chagas Disease; Drug Design; Humans; Models, Molecular; Nitrofurans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Mice; Molecular Docking Simulation; Parasitemia; Pyrazolones; Structure-Activity Relationship; Survival Rate; Thiazepines; Trypanosoma cruzi | 2018 |
Identification and preliminary structure-activity relationship studies of novel pyridyl sulfonamides as potential Chagas disease therapeutic agents.
Topics: Animals; Cell Survival; Cells, Cultured; Chagas Disease; Dose-Response Relationship, Drug; Mice; Molecular Structure; Pyridines; Structure-Activity Relationship; Sulfonamides | 2018 |
Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase.
Topics: Amination; Chagas Disease; Drug Design; Glycoproteins; Humans; Molecular Docking Simulation; Neuraminidase; Propionates; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents.
Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania donovani; Molecular Structure; Parasitic Sensitivity Tests; Quinoxalines; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi | 2018 |
Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry.
Topics: | 2018 |
Nongenotoxic 3-Nitroimidazo[1,2-
Topics: | 2019 |
Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Growth Inhibitors; Humans; Molecular Structure; Parasitic Sensitivity Tests; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
Topics: Dose-Response Relationship, Drug; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2020 |
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
In vitro, ex vivo and in vivo short-term screening of DHEA nitrate derivatives activity over Trypanosoma cruzi Ninoa and TH strains from Oaxaca State, México.
Topics: Animals; Cell Line; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Mexico; Mice; Molecular Structure; Nitrates; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Trypanocidal drugs and their effect on parasitaemia, specific IgG production and protective immunity in rats infected with Trypanosoma lewisi.
Topics: Animals; Antibodies, Protozoan; Diminazene; Ethidium; Female; Immunoglobulin G; Nifurtimox; Nitroimidazoles; Rats; Rats, Inbred F344; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis | 1992 |
Experimental chemotherapy of Trypanosoma cruzi infection: persistence of parasite antigens and positive serology in parasitologically cured mice.
Topics: Animals; Antigens, Protozoan; Chagas Disease; Mice; Microscopy, Immunoelectron; Nifurtimox; Nitroimidazoles; Spleen; Trypanocidal Agents | 1991 |
Lack of sensitivity of sister-chromatid exchange for lymphocyte chromosomal damage detection caused by antichagasic treatment.
Topics: Chagas Disease; Child; Child, Preschool; Chromosomes; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes; Male; Nifurtimox; Nitroimidazoles; Sister Chromatid Exchange; Trypanocidal Agents | 1991 |
Trypanocidal nitroarene treatment of experimental Trypanosoma cruzi infection does not prevent progression of chronic-phase heart lesions in rabbits.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Nifurtimox; Nitroimidazoles; Rabbits; Trypanocidal Agents | 1990 |
Malignant, non-Hodgkin's lymphomas in Trypanosoma cruzi-infected rabbits treated with nitroarenes.
Topics: Animals; Chagas Cardiomyopathy; Female; Injections, Intraperitoneal; Lymphoma, Non-Hodgkin; Male; Myocarditis; Myositis; Nifurtimox; Nitrofurans; Nitroimidazoles; Rabbits; Trypanosoma cruzi | 1990 |
Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections.
Topics: Animals; Chagas Disease; Ferredoxins; Microsomes, Liver; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Rats; Subcellular Fractions; Thiadiazoles; Trypanosoma cruzi | 1989 |
[Chagas' disease in patients with renal transplantation].
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Immune Tolerance; Kidney Transplantation; Male; Nifurtimox; Nitroimidazoles; Serologic Tests; Transfusion Reaction; Trypanocidal Agents | 1989 |
Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Diazooxonorleucine; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Methionine Sulfoximine; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1989 |
Effects of nitroheterocyclic drugs on macromolecule synthesis and degradation in Trypanosoma cruzi.
Topics: Animals; DNA; Leucine; Macromolecular Substances; Nifurtimox; Nitro Compounds; Nitroimidazoles; Protein Biosynthesis; Proteins; RNA; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Uridine | 1985 |
[Nifurtimox and benznidazole inhibit DNA and protein synthesis in rat hepatocytes].
Topics: Animals; DNA; Liver; Male; Nifurtimox; Nitrofurans; Nitroimidazoles; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1988 |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi.
Topics: Animals; Crithidia; In Vitro Techniques; Nifurtimox; Nitrofurans; Nitroimidazoles; Protein Biosynthesis; Trypanocidal Agents; Trypanosoma cruzi | 1989 |
Ultrastructural alterations in ovaries from nifurtimox or benznidazole-treated rats: their relation to ovarian nitroreductive biotransformation of both drugs.
Topics: Animals; Biotransformation; Cytosol; Female; Microscopy, Electron; Microsomes; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Ovary; Oxidoreductases; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1989 |
Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole.
Topics: Bacteria; Bacteria, Aerobic; Bacteria, Anaerobic; Microbial Sensitivity Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1989 |
The reductive metabolism of nifurtimox and benznidazole in Crithidia fasciculata is similar to that in Trypanosoma cruzi.
Topics: Animals; Crithidia; Free Radicals; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Trypanocidal Agents; Trypanosoma cruzi | 1988 |
Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Drug Resistance; Macrophages; Male; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 1988 |
Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Male; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1987 |
[Chagas' disease: clastogenic effect of nifurtimox and benznidazole in children].
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Chromosome Banding; Chromosome Fragility; Humans; Infant; Metaphase; Micronucleus Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1988 |
Evaluation of genotoxic activity in the blood and urine of guinea pigs treated with nifurtimox and benznidazole.
Topics: Animals; Female; Guinea Pigs; Male; Mutagenicity Tests; Mutation; Nifurtimox; Nitrofurans; Nitrofurantoin; Nitroimidazoles | 1988 |
Activation of anti-Trypanosoma cruzi drugs to genotoxic metabolites promoted by mammalian microsomal enzymes.
Topics: Animals; Biotransformation; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Rats; Salmonella typhimurium; Trypanosoma cruzi | 1988 |
Liver microsomal benznidazole and nifurtimox nitroreductase activity in male rats of different age.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1987 |
Mutagenicity of nifurtimox and benznidazole in the Salmonella/microsome assay.
Topics: Mutagenicity Tests; Mutagens; Nifurtimox; Nitrofurans; Nitroimidazoles; Salmonella typhimurium | 1986 |
Genotoxicity studies with two antichagasic drugs.
Topics: Drug Resistance, Microbial; Escherichia coli; Lysogeny; Mutagenicity Tests; Mutation; Nifurtimox; Nitrofurans; Nitroimidazoles; Salmonella typhimurium; SOS Response, Genetics; Trypanocidal Agents | 1987 |
Sister-chromatid exchange in spleenic lymphocytes of mice after exposure to nifurtimox or benznidazole.
Topics: Animals; Lymphocytes; Male; Mice; Mutagenicity Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Sister Chromatid Exchange; Spleen | 1987 |
Species and sex differences in the liver microsomal nitroreductive biotransformation of nifurtimox and benznidazole.
Topics: Animals; Biotransformation; Cricetinae; Female; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Mice; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Trypanocidal Agents | 1987 |
Effects of nifurtimox or benznidazole administration on rat testes: ultrastructural observations and biochemical studies.
Topics: Animals; Biotransformation; Cytosol; Endoplasmic Reticulum; Lipid Peroxides; Male; Microscopy, Electron; Microsomes; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Organoids; Phospholipids; Protein Binding; Rats; Rats, Inbred Strains; Sertoli Cells; Spermatozoa; Testis | 1986 |
Benznidazole and nifurtimox nitroreductase activity in liver microsomes from male rats preinduced with phenobarbital or 3-methylcholanthrene.
Topics: Animals; Biotransformation; Male; Methylcholanthrene; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Damage of Trypanosoma cruzi deoxyribonucleic acid by nitroheterocyclic drugs.
Topics: Animals; DNA; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1985 |
Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types.
Topics: Animals; Chagas Disease; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Species Specificity; Trypanocidal Agents | 1985 |
Studies on pentane evolution by rats treated with nifurtimox or benznidazole.
Topics: Animals; Carbon Tetrachloride; Lipid Peroxides; Male; Nifurtimox; Nitrofurans; Nitroimidazoles; Pentanes; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1985 |
Micronucleus formation in bone marrow of mice treated with nifurtimox or benznidazole.
Topics: Animals; Bone Marrow; Cell Nucleus; Male; Mice; Mutagens; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1985 |
[Different effects of nifurtimox and benznidazole on the biosynthesis of DNA, RNA and proteins in Trypanosoma cruzi].
Topics: Animals; DNA; Nifurtimox; Nitrofurans; Nitroimidazoles; Protein Biosynthesis; RNA; Trypanocidal Agents; Trypanosoma cruzi | 1984 |
[Effects of nifurtimox, benznidazole, and beta-lapachone on the metabolism of DNA, RNA and proteins in Trypanosoma cruzi].
Topics: Animals; Depression, Chemical; DNA; DNA Damage; Free Radicals; Naphthoquinones; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxygen; Protein Biosynthesis; RNA; Trypanocidal Agents; Trypanosoma cruzi | 1983 |
[Undesirable effects of benznidazole and nifurtimox].
Topics: Animals; Hydrogen Peroxide; In Vitro Techniques; Microsomes, Liver; NADP; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxygen Consumption; Rats; Superoxides; Trypanosoma cruzi | 1983 |
[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].
Topics: Animals; DNA; DNA Damage; DNA Repair; Free Radicals; Naphthoquinones; Nifurtimox; Nitroimidazoles; Oxidation-Reduction; Trypanocidal Agents; Trypanosoma cruzi | 1984 |
Chronic Chagas' disease in the mouse. IV. Effect of trypanocidal drugs.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Female; Intestinal Diseases, Parasitic; Mice; Mice, Inbred Strains; Myositis; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1983 |
Effect of nitroheterocyclic drugs on lipid peroxidation and glutathione content in rat liver extracts.
Topics: Animals; Free Radicals; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Male; Malondialdehyde; Nifurtimox; Nitrofurans; Nitroimidazoles; Rats; Rats, Inbred Strains; Tissue Extracts; Trypanocidal Agents | 1984 |
Nitroreduction of benznidazole and nifurtimox by rat and human feces.
Topics: Animals; Feces; Humans; Male; Neomycin; Nifurtimox; Nitro Compounds; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
The efficacy of a novel compound, (e)-1-(4'-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene against Trypanosoma cruzi in mice.
Topics: Animals; Biphenyl Compounds; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1982 |
[Treatment of Chagas disease].
Topics: Amphotericin B; Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1981 |
[Etiological treatment of Chagas' disease].
Topics: Animals; Chagas Disease; Humans; Mice; Nifurtimox; Nitrofurans; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 1982 |
[Undesirable effects of nifurtimox and benznidazole].
Topics: Humans; Nifurtimox; Nitrofurans; Nitroimidazoles | 1982 |
Chagas' disease: carcinogenic activity of the antitrypanosomal nitroarenes in mice.
Topics: Animals; Carcinogens; Cell Division; Chagas Disease; Female; Liver; Lymph Nodes; Lymphoma; Mice; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1994 |
Use of Trypanosoma cruzi purified glycoprotein (GP57/51) or trypomastigote-shed antigens to assess cure for human Chagas' disease.
Topics: Acute Disease; Adsorption; Adult; Animals; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Chagas Disease; Child; Chronic Disease; Cross Reactions; Cysteine Endopeptidases; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Follow-Up Studies; Glycoproteins; Humans; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 1993 |
Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cycloheximide; Glutathione; Nifurtimox; Nitroimidazoles; Species Specificity; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 1996 |
Effects of nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi.
Topics: Animals; Glutathione; Nifurtimox; Nitroimidazoles; Spermidine; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 1997 |
Phenotype of recombinant Trypanosoma cruzi which overexpress elongation factor 1-gamma: possible involvement of EF-1gamma GST-like domain in the resistance to clomipramine.
Topics: Animals; Clomipramine; DNA, Complementary; Drug Resistance; Glutathione Transferase; Nifurtimox; Nitroimidazoles; Peptide Elongation Factor 1; Peptide Elongation Factors; Phenotype; Trypanocidal Agents; Trypanosoma cruzi | 1997 |
Trypanosoma cruzi: impact of clonal evolution of the parasite on its biological and medical properties.
Topics: Animals; Biological Evolution; Chagas Disease; Chlorocebus aethiops; Cluster Analysis; Discriminant Analysis; DNA, Protozoan; Electrophoresis, Cellulose Acetate; Genetic Variation; Genotype; Humans; Isoenzymes; Monte Carlo Method; Nifurtimox; Nitroimidazoles; Phylogeny; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1998 |
Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brazil; Chagas Disease; DNA, Protozoan; DNA, Ribosomal; Drug Resistance; Exons; Genes, Protozoan; Genetic Variation; Glucose-6-Phosphate Isomerase; Humans; Hypoxanthine Phosphoribosyltransferase; Isoenzymes; Nifurtimox; Nitroimidazoles; Polymorphism, Genetic; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.
Topics: Animals; Cells, Cultured; DNA Replication; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance; Gamma Rays; Muscle, Skeletal; Nifurtimox; Nitroimidazoles; Rats; Reproduction; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi; Uracil | 1998 |
Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele.
Topics: Alleles; Amino Acid Sequence; Animals; Antimony; Base Sequence; DNA, Protozoan; Gene Deletion; Macrophages; Metals, Heavy; Molecular Sequence Data; Nifurtimox; Nitroimidazoles; Oligonucleotides, Antisense; Phenotype; Protozoan Proteins; Transcription, Genetic; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
Synthesis and antichagasic properties of new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides and related compounds.
Topics: Animals; Chlorocebus aethiops; Humans; Magnetic Resonance Spectroscopy; Nifurtimox; Nitroimidazoles; Spectrophotometry, Infrared; Thiadiazines; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1999 |
Etiological treatment for infection by Trypanosoma cruzi.
Topics: AIDS-Related Opportunistic Infections; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1999 |
Congenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in north-western Argentina.
Topics: Adult; Animals; Argentina; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Hemagglutination Tests; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Middle Aged; Nifurtimox; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents | 2000 |
Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.
Topics: Animals; Antigens, Protozoan; Cathepsin B; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Microbial; Flow Cytometry; Glycoproteins; Immunoblotting; Immunohistochemistry; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Setting of a colorimetric method to determine the viability of Trypanosoma cruzi epimastigotes.
Topics: Animals; Colorimetry; Culture Media; Nifurtimox; Nitroimidazoles; Oxidation-Reduction; Parasitic Sensitivity Tests; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Chagas Disease; Drug Resistance; Gene Amplification; Glycoproteins; Humans; Karyotyping; Mice; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Polymorphism, Restriction Fragment Length; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain.
Topics: Animals; beta-Galactosidase; Chlorocebus aethiops; Cloning, Organism; Mice; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2002 |
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives.
Topics: Animals; Inhibitory Concentration 50; Nifurtimox; Nitroimidazoles; Polycyclic Compounds; Polycyclic Sesquiterpenes; Quinones; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
[Interventional study in the natural evolution of Chagas disease. Evaluation of specific antiparasitic treatment. Retrospective-prospective study of antiparasitic therapy].
Topics: Adolescent; Adult; Aged; Allopurinol; Antiprotozoal Agents; Chagas Cardiomyopathy; Chagas Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Prospective Studies; Retrospective Studies; Time Factors; Treatment Outcome; Trypanocidal Agents | 2000 |
Inhibition of Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II by N-isopropyl oxamate and its effect on intact epimastigotes.
Topics: Alcohol Oxidoreductases; Animals; Dose-Response Relationship, Drug; Kinetics; Models, Chemical; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Protein Isoforms; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
Topics: Animals; Buthionine Sulfoximine; Electrophoresis, Polyacrylamide Gel; Glutathione; Metallothionein; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Spermidine; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts.
Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Monocytes; Nifurtimox; Nitroimidazoles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.
Topics: Animals; Buthionine Sulfoximine; Chlorocebus aethiops; Drug Synergism; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2005 |
A new pharmacological screening assay with Trypanosoma cruzi epimastigotes expressing beta-galactosidase.
Topics: Animals; beta-Galactosidase; Chlorophenols; Galactosides; Lac Operon; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Spectrophotometry; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains.
Topics: Alcohol Oxidoreductases; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Mice; Models, Chemical; NAD; Nifurtimox; Nitroimidazoles; Oxamic Acid; Species Specificity; Time Factors; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 2005 |
The need of a neonatal preparation for Chagas disease.
Topics: Chagas Disease; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease Transmission, Vertical; Nifurtimox; Nitroimidazoles; Patient Compliance; Trypanocidal Agents | 2005 |
Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.
Topics: Animals; Antifungal Agents; Blotting, Northern; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Gene Deletion; Gene Dosage; Gene Expression Profiling; Molecular Sequence Data; Molecular Weight; NADPH Dehydrogenase; Nifurtimox; Nitroimidazoles; Oligonucleotide Array Sequence Analysis; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Fungal; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology; Trypanosoma cruzi | 2006 |
Development of resazurin microtiter assay for drug sensibility testing of Trypanosoma cruzi epimastigotes.
Topics: Animals; Colorimetry; Humans; Indicators and Reagents; Nifurtimox; Nitroimidazoles; Oxazines; Oxidation-Reduction; Parasitic Sensitivity Tests; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi; Xanthenes | 2006 |
Chagas disease: hidden affliction and visible neglect.
Topics: Animals; Chagas Disease; Child; Diagnosis, Differential; Humans; Nifurtimox; Nitroimidazoles; Poverty; Risk Factors; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Topics: Animals; Gene Deletion; Genes, Protozoan; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Superoxide Dismutase; Trypanosoma brucei brucei | 2007 |
In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains.
Topics: Animals; Chagas Disease; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Topics: Animals; Cattle; Cells, Cultured; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Homeodomain Proteins; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Topics: Animals; Drug Resistance; Gene Expression Regulation; Genome, Protozoan; Mitochondria; Nifurtimox; Nitroimidazoles; Nitroreductases; Phenotype; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
[Part VI. Antiparasitic treatment for Chagas disease].
Topics: Allopurinol; Animals; Chagas Disease; Follow-Up Studies; Humans; Immunocompromised Host; Immunosuppressive Agents; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects.
Topics: Animals; Biotransformation; Drug Evaluation, Preclinical; Heart; Male; Microscopy, Electron, Transmission; Microsomes; Myocardium; Nifurtimox; Nitroimidazoles; Nitroreductases; Rats; Rats, Sprague-Dawley; Time Factors; Trypanocidal Agents | 2008 |
[Chagas disease].
Topics: Animals; Chagas Disease; Emigration and Immigration; Humans; Insect Vectors; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi.
Topics: Alcohol Dehydrogenase; Animals; Blotting, Northern; DNA, Protozoan; Drug Resistance; Humans; Immunoblotting; Mice; Molecular Weight; Nifurtimox; Nitroimidazoles; Phylogeny; Protozoan Proteins; RNA, Messenger; RNA, Protozoan; Sequence Analysis, DNA; Sequence Homology; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Chagas disease: the forgotten American neuroinfection.
Topics: Americas; Central Nervous System Diseases; Chagas Disease; History, 20th Century; History, 21st Century; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole.
Topics: Animals; Aspirin; Cell Line; Cell Survival; Cyclooxygenase Inhibitors; Drug Synergism; Inhibitory Concentration 50; Macrophages; Mice; Nifurtimox; Nitric Oxide; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
[Chagas disease and immunodeficiency: HIV infection and transplantation].
Topics: Anti-HIV Agents; Chagas Disease; France; HIV Infections; Humans; Meningoencephalitis; Nifurtimox; Nitroimidazoles; Transplantation; Trypanocidal Agents | 2009 |
Metabolization of nifurtimox and benznidazole in cellular fractions of rat mammary tissue.
Topics: Allopurinol; Animals; Cell Fractionation; Chromatography, High Pressure Liquid; Female; Lipid Peroxidation; Mammary Glands, Animal; Microscopy, Electron, Transmission; Microsomes; Nifurtimox; Nitroimidazoles; Nitroreductases; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Trypanocidal Agents | 2010 |
New drugs for neglected infectious diseases: Chagas' disease.
Topics: Animals; Chagas Disease; Humans; Nifurtimox; Nitric Oxide Donors; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.
Topics: Antiprotozoal Agents; Colombia; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Phosphorylcholine; Trypanosoma cruzi | 2009 |
Antitrypanosomal agents: treatment or threat?
Topics: Chagas Cardiomyopathy; Chagas Disease; Clinical Trials as Topic; Drug Administration Schedule; Drug Eruptions; Humans; Meta-Analysis as Topic; Nifurtimox; Nitroimidazoles; Polyneuropathies; Trypanocidal Agents; Trypanosoma cruzi; United States | 2010 |
Congenital infections with Trypanosoma cruzi or Toxoplasma gondii are associated with decreased serum concentrations of interferon-γ and interleukin-18 but increased concentrations of interleukin-10.
Topics: Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant; Infant, Newborn; Interferon-gamma; Interleukin-10; Interleukin-18; Male; Nifurtimox; Nitroimidazoles; Toxoplasmosis, Congenital; Trypanocidal Agents | 2010 |
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Topics: Amino Acid Transport Systems; Drug Resistance; Eflornithine; Gene Knockdown Techniques; Genes, Protozoan; Genome-Wide Association Study; Humans; Nifurtimox; Nitroimidazoles; Nitroreductases; RNA Interference; Trypanosoma brucei brucei | 2011 |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic Chagas disease: its relationship with treatment against parasites and myocardial damage.
Topics: Animals; Antibodies, Protozoan; Cardiomyopathies; Chagas Disease; Chronic Disease; Female; Humans; Immunity, Humoral; Male; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Ribosomal Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Supply chain problems for Chagas disease treatment.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2012 |
Nifurtimox chemotherapy: collateral effects in treated Trypanosoma cruzi infected patients.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Reactivation of Chagas' disease: cutaneous manifestations in two immunosuppressed patients.
Topics: Adult; Bone Marrow Transplantation; Chagas Disease; Female; Heart Transplantation; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Recurrence; Trypanocidal Agents | 2012 |
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
Topics: Benzoquinones; Escherichia coli; Kinetics; Mitochondria; Molecular Targeted Therapy; NAD; Nifurtimox; Nitroimidazoles; Nitroreductases; Prodrugs; Protozoan Proteins; Recombinant Proteins; Small Molecule Libraries; Structure-Activity Relationship; Substrate Specificity; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2012 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
A Practical Green Synthesis and Biological Evaluation of Benzimidazoles Against Two Neglected Tropical Diseases: Chagas and Leishmaniasis.
Topics: Amphotericin B; Antiprotozoal Agents; Benzimidazoles; Chagas Disease; Green Chemistry Technology; Heating; Leishmania mexicana; Leishmaniasis; Microwaves; Nifurtimox; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.
Topics: Animals; Chagas Disease; DNA, Protozoan; Drug Resistance; Exons; Genetic Variation; Genotype; Humans; Insect Vectors; Mexico; Microsatellite Repeats; Nifurtimox; Nitroimidazoles; Opossums; Phylogeny; Polymerase Chain Reaction; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment.
Topics: Adolescent; Adult; Chagas Disease; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2013 |
Development of an ionic liquid-based dispersive liquid-liquid microextraction method for the determination of nifurtimox and benznidazole in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Ionic Liquids; Limit of Detection; Liquid Phase Microextraction; Nifurtimox; Nitroimidazoles; Reproducibility of Results; Trypanocidal Agents | 2013 |
Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of nifurtimox and benznidazole.
Topics: Alcohol Drinking; Animals; Drug Interactions; Female; Male; Microsomes, Liver; Nifurtimox; Nitroimidazoles; Nitroreductases; Rats; Rats, Sprague-Dawley; Trypanocidal Agents | 2013 |
Evaluation of the ELISA-F29 test as an early marker of therapeutic efficacy in adults with chronic Chagas disease.
Topics: Adolescent; Adult; Antibodies, Protozoan; Antigens, Protozoan; Case-Control Studies; Chagas Disease; Chronic Disease; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Retrospective Studies; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish.
Topics: Animals; Drug Evaluation, Preclinical; Embryo, Nonmammalian; High-Throughput Screening Assays; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Zebrafish | 2013 |
Towards a paradigm shift in the treatment of chronic Chagas disease.
Topics: Adolescent; Adult; Antibodies, Protozoan; Chagas Cardiomyopathy; Child; Chronic Disease; Disease Management; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Cytotoxic, mutagenic and genotoxic evaluation of crude extracts and fractions from Piper jericoense with trypanocidal action.
Topics: Cell Survival; Cells, Cultured; Chemical Fractionation; Culture Media; Humans; Life Cycle Stages; Lymphocytes; Mutagenicity Tests; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Piper; Plant Extracts; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.
Topics: Antiprotozoal Agents; Codon, Nonsense; Drug Resistance; Gene Deletion; Nifurtimox; Nitroimidazoles; Nitroreductases; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2014 |
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants.
Topics: Antiparasitic Agents; Chorionic Villi; Female; Histocytochemistry; Humans; Immunohistochemistry; In Vitro Techniques; Microscopy, Fluorescence; Nifurtimox; Nitroimidazoles; Parasite Load; Placenta; Pregnancy; Real-Time Polymerase Chain Reaction; Trypanosoma cruzi | 2014 |
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
Topics: Animals; Apoptosis; Artemisia; Chlorocebus aethiops; Lactones; Molecular Structure; Nifurtimox; Nitroimidazoles; Sesquiterpenes; Sesquiterpenes, Guaiane; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2014 |
Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole.
Topics: Animals; Cell Death; Cell Line, Tumor; Chagas Disease; Chemical and Drug Induced Liver Injury; DNA Damage; Female; Hep G2 Cells; Humans; Liver; Male; Mice; Mitochondria; Nifurtimox; Nitrofurazone; Nitroimidazoles; Parasites; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up.
Topics: Adolescent; Adult; Aged; Arecaceae; Chagas Disease; Child; Family; Female; French Guiana; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Plant Extracts; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Profile of Trypanosoma cruzi infection in a tropical medicine reference center, Northern Italy.
Topics: Adolescent; Adult; Aged; Chagas Disease; Child; Echocardiography; Electrocardiography; Female; Humans; Italy; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Pregnancy; Retrospective Studies; Tropical Medicine; United States | 2014 |
Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line.
Topics: Animals; Automation, Laboratory; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Myoblasts; Nifurtimox; Nitroimidazoles; Rats; Trypanosoma cruzi | 2015 |
Development of an ionic-liquid-based dispersive liquid-liquid microextraction method for the determination of antichagasic drugs in human breast milk: Optimization by central composite design.
Topics: Chagas Disease; Chromatography, High Pressure Liquid; Humans; Imidazoles; Ionic Liquids; Liquid Phase Microextraction; Milk, Human; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Ultraviolet Rays | 2015 |
Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease.
Topics: Alcohol Oxidoreductases; Animals; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Esters; Isoenzymes; Male; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Access to care for Chagas disease in the United States: a health systems analysis.
Topics: Blood Donors; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Clinical Competence; Delivery of Health Care; Drugs, Investigational; Health Services Accessibility; Humans; Nifurtimox; Nitroimidazoles; Referral and Consultation; Systems Analysis; Trypanocidal Agents; United States | 2015 |
A flow cytometer-based method to simultaneously assess activity and selectivity of compounds against the intracellular forms of Trypanosoma cruzi.
Topics: Chagas Disease; Drug Discovery; Flow Cytometry; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM).
Topics: Adult; Chagas Cardiomyopathy; DNA, Protozoan; Heart Transplantation; Humans; Male; Nifurtimox; Nitroimidazoles; Phylogeny; Recurrence; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Perspectives in Chagas disease treatment.
Topics: Animals; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Death, Sudden, Cardiac; Defibrillators, Implantable; Disease Management; Heart Failure; Humans; Insect Control; Insect Vectors; Nifurtimox; Nitroimidazoles; Thromboembolism; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Acute Chagas outbreaks: molecular and biological features of Trypanosoma cruzi isolates, and clinical aspects of acute cases in Santander, Colombia.
Topics: Acute Disease; Animals; Base Sequence; Chagas Disease; Colombia; Disease Outbreaks; DNA, Protozoan; Exons; Female; Genetic Variation; Genotype; Humans; Male; Molecular Sequence Data; Nifurtimox; Nitroimidazoles; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes.
Topics: Animals; Chagas Disease; Electrophoresis, Gel, Two-Dimensional; Mice; Naphthoquinones; Nifurtimox; Nitroimidazoles; Proteomics; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Long-term comparative pharmacovigilance of orally transmitted Chagas disease: first report.
Topics: Chagas Disease; Cross-Sectional Studies; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Pharmacovigilance; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
[Treatment and follow up of Chagas Disease in immunocompromised hosts].
Topics: Chagas Disease; Follow-Up Studies; HIV Infections; Humans; Immunocompetence; Immunocompromised Host; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents | 2017 |
[Estimating demand for anti-Chagas drugs: a contribution for access in Latin America].
Topics: Adolescent; Adult; Chagas Disease; Child; Child, Preschool; Humans; Infant; Latin America; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2017 |
Access to benznidazole for Chagas disease in the United States-Cautious optimism?
Topics: Centers for Disease Control and Prevention, U.S.; Chagas Disease; Drug Costs; Drugs, Investigational; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.
Topics: Antiprotozoal Agents; Chagas Disease; Cysteine Endopeptidases; High-Throughput Screening Assays; Host-Parasite Interactions; Humans; Kinetoplastida; Molecular Docking Simulation; Molecular Structure; Nifurtimox; Nitroimidazoles; Protein Domains; Protozoan Proteins; Trypanosoma cruzi | 2017 |
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
Topics: Animals; Brain; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Female; Heart; Humans; Infant; Infectious Disease Transmission, Vertical; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Myocardium; Nifurtimox; Nitroimidazoles; Parasitemia; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Male; Mice; Nifurtimox; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail.
Topics: Adult; Chagas Disease; Chronic Disease; Cohort Studies; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Prospective Studies; Retreatment; Trypanosoma cruzi | 2018 |
Chagas disease: An underrecognized diagnosis.
Topics: Acute-Phase Reaction; Cardiomyopathies; Chagas Disease; Chronic Disease; Diagnosis, Differential; Female; Humans; Male; Megacolon; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States | 2018 |
Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi.
Topics: Antiprotozoal Agents; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Associated Protein 9; Electroporation; Gene Expression; Gene Knockout Techniques; Genetics, Microbial; Molecular Biology; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2019 |
Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi.
Topics: Allopurinol; Animals; Cell Line; Chagas Disease; Humans; Mice; Mortality; Nifurtimox; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanosoma cruzi | 2019 |
Developments on treatment of Chagas disease - from discovery to current times.
Topics: Chagas Disease; Drug Repositioning; Humans; Molecular Structure; Nifurtimox; Nitroimidazoles; Prognosis; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents.
Topics: Blood Cells; Cell Survival; Comet Assay; DNA Damage; Humans; Micronucleus Tests; Nifurtimox; Nitroimidazoles; Reference Values; Reproducibility of Results; Thiadiazoles; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Phenothiazinium Dyes Are Active against
Topics: Animals; Cell Line; Cell Proliferation; Chagas Disease; Coloring Agents; Humans; Methylene Blue; Nifurtimox; Nitroimidazoles; Phenothiazines; Tolonium Chloride; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease.
Topics: Adult; Chagas Disease; Chronic Disease; Drug Tolerance; Humans; Nifurtimox; Nitroimidazoles; Switzerland; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Gastrointestinal Tract; Heart; Host-Parasite Interactions; Humans; Nifurtimox; Nitroimidazoles; Prognosis; Treatment Outcome; Trypanosoma cruzi | 2020 |
In vitro susceptibility to benznidazole, nifurtimox and posaconazole of Trypanosoma cruzi isolates from Paraguay
Topics: Analysis of Variance; Genotype; Lethal Dose 50; Nifurtimox; Nitroimidazoles; Paraguay; Phenotype; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Levels of anti-B13 antibodies over time in a cohort of chronic infected by Trypanosoma cruzi. Its relationship with specific treatment and clinical status.
Topics: Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Argentina; Chagas Disease; Chronic Disease; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Nifurtimox; Nitroimidazoles; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2021 |
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Humans; Inhibitory Concentration 50; Mice; Neglected Diseases; Nifurtimox; Nitro Compounds; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Sulfones | 2021 |
Assessing antibody decline after chemotherapy of early chronic Chagas disease patients.
Topics: Adolescent; Antibodies, Protozoan; Chagas Disease; Chronic Disease; Cohort Studies; Female; Humans; Immunoglobulin G; Immunologic Tests; Male; Molecular Diagnostic Techniques; Nifurtimox; Nitroimidazoles; Pilot Projects; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi.
Topics: Chagas Disease; Dinoprost; Humans; Nifurtimox; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi; Vitamin K 3 | 2022 |
Long-term cardiology outcomes in children after early treatment for Chagas disease, an observational study.
Topics: Adult; Cardiology; Chagas Cardiomyopathy; Chagas Disease; Child; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Effect of B-NIPOx in Experimental
Topics: Animals; Chagas Disease; Isoenzymes; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |