Compounds > benzonidazole
Page last updated: 2024-08-23

benzonidazole and miltefosine

benzonidazole has been researched along with miltefosine in 108 studies

Research

Studies (108)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's24 (22.22)29.6817
2010's72 (66.67)24.3611
2020's12 (11.11)2.80

Authors

AuthorsStudies
Boykin, DW; Brun, R; Salem, MM; Stephens, CE; Tanious, F; Werbovetz, KA; Wilson, WD1
Bringmann, G; Brun, R; Christensen, SB; Dalsgaard, PW; Dreyer, M; Faber, JH; Jaroszewski, JW; Maksimenka, K; Mbago, F; Ndangalasi, H; Reichert, M; Staerk, D1
Bringmann, G; Brun, R; Christensen, SB; Dalsgaard, PW; Dreyer, M; Faber, JH; Jaroszewski, JW; Mbago, F; Ndangalasi, H; Staerk, D1
Bringmann, G; Brun, R; Dreyer, M; Hadi, HA; Heubl, G; Meimberg, H; Rischer, H; Wolf, K1
Brun, R; Cimanga, K; Dommisse, R; Hostyn, S; Kaiser, M; Lemière, G; Maes, BU; Mátyus, P; Pieters, L; Van Miert, S; Vlietinck, A1
Ahua, KM; Brun, R; Diallo, D; Hay, AE; Hostettmann, K; Ioset, JR1
Bringmann, G; Brun, R; Kaiser, M; Neumann, S1
Brun, R; Dong, Y; Hemphill, A; Kaiser, M; Matile, H; Nehrbass-Stuedli, A; Vennerstrom, JL; Wang, X; Wittlin, S1
Brun, R; Carballeira, NM; Linden, A; O'Neill, R; Perozzo, R; Rüedi, P; Tasdemir, D; Tonge, PJ; Topaloglu, B; Zhang, X1
Brun, R; Gunzenhauser, S; Senn, M; Séquin, U1
Brun, R; Kaiser, M; Kuettel, S; Perozzo, R; Scapozza, L; Zambon, A1
Bolognesi, ML; Brun, R; Cavalli, A; Lizzi, F; Perozzo, R1
Arai, C; Brun, R; Ge, JF; Ihara, M; Kaiser, M; Wittlin, S1
Brun, R; Kehraus, S; König, GM; Krick, A; Pontius, A1
Aguirre, G; Bertinaria, M; Boiani, L; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; González, M; Guglielmo, S1
Baell, JB; Brun, R; Charman, WN; Fairlamb, AH; Holloway, GA; Kaiser, M; Kostewicz, E; Novello, PM; Parisot, JP; Richardson, J; Street, IP; Watson, KG1
Bolognesi, ML; Bongarzone, S; Brun, R; Cavalli, A; Lizzi, F; Luise Krauth-Siegel, R1
Brun, R; Dardonville, C; Fernández-Fernández, C; Gibbons, SL; Jagerovic, N; Kaiser, M; Nieto, L; Ryan, G1
Boiani, L; Boiani, M; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; González, M; Hernández, P; Merlino, A1
Brun, R; Cos, P; Dhooghe, L; Dommisse, R; Hajós, G; Hostyn, S; Kaiser, M; Lemière, G; Maes, BU; Maes, L; Mátyus, P; Nagy, I; Pieters, L; Riedl, Z; Tapolcsányi, P; Van Baelen, G1
Brun, R; Franzblau, SG; Huang, Q; Kozikowski, AP; Mao, J; Wan, B; Wang, Y1
Benitez, D; Boiani, L; Castro, D; Cerecetto, H; Gil, C; González, M; Hernández, P; Merlino, A; Olea-Azar, C; Porcal, W1
Brun, R; Lusvarghi, S; Mazzieri, MR; Pagliero, RJ; Pierini, AB1
Armstrong, T; Baell, JB; Holloway, GA; Novello, PM; Parisot, JP; Street, IP; Thompson, RC; Watson, KG1
Gondela, E; Walczak, KZ1
Amade, P; Cachet, N; Kaiser, M; Regalado, EL; Tasdemir, D; Thomas, OP1
Baumann, K; Bischof, SK; Bringmann, G; Brun, R; Dreher, J; Gulder, T; Kaiser, M; Moll, H; Müller, S; Stich, A; Winter, C1
Brun, R; Carballeira, NM; Herman, R; Kappe, SH; Lauinger, IL; Perozzo, R; Sanabria, D; Tarun, A; Tasdemir, D; Zloh, M1
Bourguet-Kondracki, ML; Copp, BR; Finlayson, R; Harper, JL; Kaiser, M; Page, MJ; Pearce, AN; Webb, VL1
Gerth, K; Jansen, R; Mohr, KI; Müller, R; Okanya, PW1
Aldana, I; Benitez, D; Boiani, L; Cabrera, M; Cerecetto, H; Di Maio, R; Ferreira, ME; González, M; Hernández, P; Lavaggi, ML; López de Ceráin, A; Monge, A; Moreno, E; Pérez-Silanes, S; Serna, E; Solano, B; Torres, E; Torres, S; Vera de Bilbao, N; Yaluff, G1
Chan, ST; Copp, BR; Kaiser, M; Page, MJ; Pearce, AN1
Brun, R; Ge, JF; Ihara, M; Kaiser, M; Liu, BQ; Shi, XL; Wittlin, S1
Anizon, F; Bouchikhi, F; Brun, R; Moreau, P1
Bloomer, WD; Brun, R; Kaiser, M; McKenzie, C; Papadopoulou, MV; Prasittichai, C; Torreele, E; Trunz, BB; Wilkinson, SR1
Brun, R; Huang, TL; Kaiser, M; Mayence, A; Vanden Eynde, JJ; Yarlett, N1
Dürüst, Y; Kaiser, M; Karakuş, H; Tasdemir, D1
Boshoff, HI; Boyd, PD; Copp, BR; Kaiser, M; McCracken, ST1
Bettis, S; Brun, R; Fomovska, A; Huang, Q; Kaiser, M; Kozikowski, AP; McLeod, R; Mui, E; Pieroni, M; Stec, J; Witola, WH1
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; McKenzie, C; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR1
Balaña-Fouce, R; Carballeira, NM; Cartagena, M; Prada, CF; Reguera, RM; Sanabria, D; Tasdemir, D1
Belluti, F; Bergamini, C; Bolognesi, ML; Brun, R; Hall, DG; Kaiser, M; Krauth-Siegel, RL; Lizzi, F; López-Sánchez, A; Rivas, L; Veronesi, G1
Copp, BR; Kaiser, M; Liew, LP1
El Sayed, I; Inokuchi, T; Kaiser, M; Lu, WJ; Maeda, T; Mei, ZW; Pang, CQ; Peng, W; Wang, L1
Arafa, RK; Boykin, DW; Brun, R; Ismail, MA; Jones, SK; Pandharkar, T; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA; Zhu, X1
Almohaywi, B; Avery, VM; Baell, JB; Campbell, M; Charman, SA; Ferrins, L; Hyland, C; Jones, AJ; Kaiser, M; Rahmani, R; Ryan, E; Smith, J; Sykes, ML; Teston, E; White, KL; Yin, J1
Brun, R; Harel, D; Prinz, H; Schepmann, D; Schmidt, TJ; Wünsch, B1
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS1
Alfonso, J; Bilbao-Ramos, P; Bolás-Fernández, F; Coronel, C; Dea-Ayuela, MA; Galiana-Roselló, C; García-España, E; González-Rosende, ME; Rolón, M; Vega, C1
Botta, B; Brun, R; Costi, R; De Vita, D; Di Santo, R; Friggeri, L; Kaiser, M; Moraca, F; Scipione, L; Tortorella, S; Zamperini, C1
Avery, VM; Baell, JB; Bergström, CA; Charman, SA; Ferrins, L; Gazdik, M; Jones, AJ; Kaiser, M; Rahmani, R; Ryan, E; Sykes, ML; Varghese, S; White, KL1
Freitas-Junior, LH; Goo, J; Han, D; Kim, S; Kong, S; Lee, N; Oh, S; Siqueira-Neto, JL; Song, R; Yang, G1
Bode, HB; Kaiser, M; Nollmann, FI; Reimer, D; Schultz, K1
Ariën, KK; Augustyns, K; Cos, P; Dirié, B; Heeres, J; Joossens, J; Lewi, PJ; Lyssens, S; Maes, L; Michiels, J; Van der Veken, P; Vanham, G; Venkatraj, M1
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR1
Battistuzzi, G; Giannini, G; Vignola, D1
Dardonville, C; Kaiser, M; Montalvo-Quirós, S; Taladriz-Sender, A1
Andersen, RJ; Berlinck, RG; da Costa-Silva, TA; Ferreira, AG; Hajdu, E; Harper, PM; Mesquita, JT; Murphy, PJ; Pinto, ÉG; Santos, MF; Santos, RA; Tempone, AG; Williams, DE1
Bergamini, C; Bolognesi, ML; Brun, R; Cavalli, A; Falchi, F; Fato, R; Kaiser, M; Molina, MT; Prati, F1
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR1
Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR1
Bosc, D; Cojean, S; Dubois, J; Franco, CH; Freitas-Junior, LH; Grellier, P; Loiseau, PM; Moraes, CB; Mouray, E1
Dias, RZ; Fernandes, JP; Ferreira, DD; Lago, JH; Martins, LF; Tempone, AG; Ueno, AK; Varela, MT1
De Vita, D; Di Santo, R; Maes, L; Matheeussen, A; Moraca, F; Pandolfi, F; Scipione, L; Tortorella, S; Zamperini, C1
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR2
Andrade, CH; Bennett, EL; Berlinck, RG; Black, GP; Borborema, SE; Costa-Silva, TA; Evans, DM; Fituri, HS; Galisteo Junior, AJ; Harper, PM; Howard-Jones, A; Leyland, JP; Martin, C; Martins, LF; Mesquita, JT; Murphy, PJ; Neves, BJ; Overman, LE; Pinto, EG; Roberts, TD; Shuhaib, ZA; Tempone, AG; Thomas, DA; Thornhill, AJ; Vale, SA; Williams, HL1
Bringmann, G; Brun, R; Brünnert, D; Chatterjee, M; Efferth, T; Feineis, D; Kaiser, M; Li, J; Mudogo, V; Seo, EJ; Seupel, R1
Back, TG; Brun, R; Kaiser, M; Manivannan, S; Pastor, A; Snyder, FF; Tran, HA; Wen, X; Zheng, Z1
Ang, CW; Blaskovich, MAT; Cooper, MA; Jarrad, AM1
Argüello-Garcia, R; Barbosa-Cabrera, E; Chan-Bacab, MJ; Colín-Lozano, B; Hernández-Núñez, E; León-Rivera, I; López-Guerrero, V; Moo-Puc, R; Navarrete-Vázquez, G; Ortega-Morales, BO; Scior, T1
Brun, R; Kaiser, M; Mazzieri, MR; Nieto, MJ; Pagliero, RJ1
Chianese, G; Erpenbeck, D; Kaiser, M; Luciano, P; Merten, C; Silber, J; Tasdemir, D; Topaloglu, B1
Borborema, SET; Cadelis, MM; Copp, BR; Costa Silva, TA; Ferreira, DD; Galuppo, MK; Guerra, JM; Lai, RYL; Lima, ML; Reimão, JQ; Russell, AJ; Tempone, AG; Wynne, GM1
Awale, S; Bringmann, G; Bruhn, T; Brun, R; Feineis, D; Kaiser, M; Li, J; Mudogo, V; Seupel, R1
Augustyns, K; Caljon, G; Heeres, J; Joossens, J; Lewi, PJ; Maes, L; Salado, IG; Van der Veken, P; Venkatraj, M1
Alcantara, LM; Cordeiro-da-Silva, A; Costantino, L; Costi, MP; Ellinger, B; Ferrari, S; Franco, CH; Freitas-Junior, LH; Gul, S; Kuzikov, M; Linciano, P; Luciani, R; Macedo, S; Moraes, CB; Pascoalino, B; Quotadamo, A; Santarem, N; Witt, G1
Bringmann, G; Brun, R; Efferth, T; Feineis, D; Kaiser, M; Mudogo, V; Seo, EJ; Tshitenge, DT1
Aliabadi, A; De Mieri, M; Ebrahimi, SN; Farimani, MM; Hamburger, M; Kaiser, M; Khodaei, B; Moradi, H1
Brun, R; Calvet, CM; Costi, R; De Leo, A; De Vita, D; Di Santo, R; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Tudino, V1
Cantizani, J; Cogo, J; Corrêa, AG; Cotillo, I; Filho, BPD; Martín, JJ; Nakamura, CV; Sangi, DP; Ueda-Nakamura, T1
Bode, HB; Cai, X; Kaiser, M; Zhao, L1
Danton, O; Hamburger, M; Kaiser, M; Moridi Farimani, M; Nejad Ebrahimi, S; Neuburger, M; Potterat, O; Ramseyer, J; Salehi, P; Tabefam, M1
Battista, MR; Brun, R; Calvet, CM; Cirilli, R; Costi, R; De Leo, A; De Vita, D; Di Marco, A; Di Santo, R; Faggi, C; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pepe, G; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Summa, V; Tudino, V1
Franzblau, S; Fredriksen, KA; Gundersen, LL; Ma, R; Maes, L; Matheeussen, A; Naemi, AO; Paulsen, B; Petersen, D; Scheie, AA; Simm, R; Wan, B1
Azas, N; Basmaciyan, L; Belle Mbou, V; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, É; Casanova, M; Castera-Ducros, C; Cohen, A; Courtioux, B; Fairlamb, AH; Fersing, C; Hutter, S; Laget, M; Milne, R; Pedron, J; Piednoel, M; Primas, N; Rathelot, P; Since, M; Sournia-Saquet, A; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S1
Costa, A; López, C; Marín, C; Martín-Escolano, R; Martin-Montes, Á; Medina-Carmona, E; Rotger, C; Sánchez-Moreno, M; Vega, M1
Baptista, C; Bonucci, A; Cordeiro-da-Silva, A; Costantino, L; Costi, MP; di Pisa, F; Ellinger, B; Ferrari, S; Franco, C; Gul, S; Iacono, LD; Kuzikov, M; Landi, G; Linciano, P; Luciani, R; Mangani, S; Moraes, CB; Müller, W; Pöhner, I; Pozzi, C; Quotadamo, A; Santarem, N; Sesenna, A; Witt, G; Wittig, U1
Nair, JJ; van Staden, J1
Alunda, JM; Baptista, C; Bifeld, E; Borsari, C; Clos, J; Cordeiro-da-Silva, A; Corral, MJ; Costantino, L; Costi, MP; Eick, J; Ellinger, B; Ferrari, S; Franco, CH; Gul, S; Jiménez-Antón, MD; Kuzikov, M; Linciano, P; Luciani, R; Moraes, CB; Olías-Molero, AI; Ponterini, G; Reinshagen, J; Santarem, N; Severi, L; Tait, A; Tejera Nevado, P; Torrado, JJ; Witt, G; Wolf, M; Zander-Dinse, D1
Awale, S; Bringmann, G; Bruhn, T; Brun, R; Feineis, D; Kaiser, M; Mudogo, V; Schmidt, D; Tshitenge, DT; Würthner, F1
Al-Harrasi, A; Babanezhad Harikandei, K; Bararjanian, M; Ebrahimi, SN; Kaiser, M; Salehi, P1
Awori, RM; Bode, HB; Groß, J; Kaiser, M; Opatz, T; Zhao, L1
Andricopulo, AD; Coelho, F; Conti, C; Fernandes, FS; Ferreira, LLG; Krogh, R; Lima, SR; Rodrigues, MT; Santos, H; Zeoly, LA1
Azas, N; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, É; Brossas, JY; Castera-Ducros, C; Corvaisier, S; Courtioux, B; Destere, A; Fairlamb, AH; Fersing, C; Hutter, S; Malzert-Fréon, A; Mazier, D; Paoli-Lombardo, R; Paris, L; Pedron, J; Pinault, E; Primas, N; Rathelot, P; Seguy, L; Since, M; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S1
Bouton, J; Caljon, G; Karalic, I; Maes, L; Van Calenbergh, S1
Bouton, J; Caljon, G; Furquim d'Almeida, A; Hulpia, F; Maes, L; Van Calenbergh, S1
Bouton, J; Caljon, G; Cardoso Santos, C; Ferreira de Almeida Fiuza, L; Karalic, I; Maes, L; Mazzarella, MA; Soeiro, MNC; Van Calenbergh, S1
Bringmann, G; Feineis, D; Kaiser, M; Lombe, BK; Mudogo, V1
Börgel, F; Jabor, VAP; Kaiser, M; Krauth-Siegel, RL; Lehmkuhl, K; Nonato, MC; Schepmann, D; Schmidt, TJ; Uth, JF; Wünsch, B1
Brun, R; Celik, I; Doganc, F; Eren, G; Goker, H; Kaiser, M1
Caljon, G; de Oliveira, GM; Donola Girão, R; Hulpia, F; Jaén Batista, DDG; Karalic, I; Lin, C; Maes, L; Mazzeti, AL; Soeiro, MNC; Van Calenbergh, S1
Caljon, G; Feijens, PB; Hulpia, F; Karalic, I; Lin, C; Maes, L; Matheeussen, A; Van Calenbergh, S1
Bozza, MT; Freire-De-Lima, CG; Gibaldi, D; Heise, N; Mendonça-Previato, L; Previato, JO; Saraiva, VB1
Croft, SL; Escobar, P; Hernández, IP; Luna, KP; Rueda, CM; Zorro, MM1
Bilbao-Ramos, P; Bolás-Fernández, F; Dea-Ayuela, MA; Galiana-Roselló, C; González-Alvarez, M; González-Rosende, ME; Pérez-Serrano, J; Rolón, M; Vega, C1
Botero, A; Keatley, S; Peacock, C; Thompson, RC1
Altcheh, J; Bisio, MMC; García-Bournissen, F; Gulin, JEN; Rocco, D; Solana, ME1

Reviews

2 review(s) available for benzonidazole and miltefosine

ArticleYear
Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases.
    Journal of medicinal chemistry, 2017, 09-28, Volume: 60, Issue:18

    Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Communicable Diseases; Humans; Nitroimidazoles; Parasitic Diseases

2017
Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.
    Bioorganic & medicinal chemistry letters, 2019, 10-15, Volume: 29, Issue:20

    Topics: Amaryllidaceae; Amaryllidaceae Alkaloids; Antiprotozoal Agents; Diterpenes; Drug Evaluation, Preclinical; Humans; Isoquinolines; Molecular Structure; Phytochemicals; Plant Extracts; Structure-Activity Relationship; Trypanosoma brucei brucei

2019

Other Studies

106 other study(ies) available for benzonidazole and miltefosine

ArticleYear
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
    Bioorganic & medicinal chemistry letters, 2003, Jun-16, Volume: 13, Issue:12

    Topics: Amidines; Animals; DNA; Furans; Guanidine; Inhibitory Concentration 50; Leishmania donovani; Macrophages; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Poly dA-dT; Protozoan Proteins; Structure-Activity Relationship; Temperature; Trypanocidal Agents; Trypanosoma cruzi

2003
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
    Journal of natural products, 2003, Volume: 66, Issue:9

    Topics: Alkaloids; Animals; Antiprotozoal Agents; Isoquinolines; Leishmania donovani; Magnoliopsida; Molecular Structure; Naphthalenes; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Stereoisomerism; Tanzania; Trypanosoma cruzi

2003
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.
    Journal of natural products, 2004, Volume: 67, Issue:5

    Topics: Alkaloids; Animals; Antimalarials; Isoquinolines; Leishmania donovani; Magnoliopsida; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plants, Medicinal; Plasmodium falciparum; Tanzania; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2004
Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species ancistrocladusbenomensis.
    Journal of natural products, 2004, Volume: 67, Issue:12

    Topics: Alkaloids; Animals; Antiprotozoal Agents; Isoquinolines; Leishmania donovani; Malaysia; Molecular Structure; Naphthalenes; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Plasmodium falciparum; Trypanosoma

2004
Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.
    Journal of natural products, 2005, Volume: 68, Issue:5

    Topics: Alkaloids; Animals; Antimalarials; Apocynaceae; Indole Alkaloids; Indoles; Molecular Structure; Plasmodium falciparum; Quinolines; Structure-Activity Relationship

2005
Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.
    Journal of natural products, 2007, Volume: 70, Issue:1

    Topics: Animals; Antiprotozoal Agents; Leishmania donovani; Limonins; Mali; Meliaceae; Molecular Structure; Plant Roots; Plants, Medicinal; Plasmodium falciparum; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2007
Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:1

    Topics: Alkaloids; Animals; Antiprotozoal Agents; Eukaryota; Isoquinolines; Myoblasts, Skeletal

2008
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Antimalarials; Artemisinins; Eukaryota; Heterocyclic Compounds, 1-Ring; Iron; Parasitic Sensitivity Tests; Peroxides; Plasmodium falciparum; Sesquiterpenes; Spiro Compounds

2007
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
    Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21

    Topics: Agelas; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimalarials; Bacterial Proteins; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Marine Biology; Mycobacterium tuberculosis; Plasmodium falciparum; Protozoan Proteins

2007
Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii.
    Journal of natural products, 2007, Volume: 70, Issue:10

    Topics: Animals; Antiprotozoal Agents; Araliaceae; Leishmania donovani; Molecular Structure; Plants, Medicinal; Plasmodium falciparum; Polyynes; Tanzania; Trypanosoma brucei rhodesiense

2007
Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
    Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23

    Topics: Animals; Antimalarials; Leishmania donovani; Morpholines; Plasmodium falciparum; Pyrazoles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma

2007
Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.
    Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7

    Topics: Animals; Anthraquinones; Antiprotozoal Agents; Drug Design; Inhibitory Concentration 50; Leishmania; Models, Chemical; Naphthoquinones; Parasitic Sensitivity Tests; Trypanosoma

2008
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives.
    Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12

    Topics: Animals; Antimalarials; Antiprotozoal Agents; Chloroquine; Drug Resistance; Leishmania donovani; Oxazines; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2008
Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.
    Journal of natural products, 2008, Volume: 71, Issue:9

    Topics: Animals; Antiprotozoal Agents; Bacillus megaterium; Chaetomium; Chlorella; Drug Screening Assays, Antitumor; Escherichia coli; Leishmania donovani; Marine Biology; Microbial Sensitivity Tests; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Trypanosoma cruzi; Xanthones

2008
Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: Animals; Dose-Response Relationship, Drug; Leishmania; Molecular Structure; Nitrites; Oxadiazoles; Parasitic Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi

2008
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Animals; Antiparasitic Agents; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Molecular Structure; NADH, NADPH Oxidoreductases; Structure-Activity Relationship; Trypanosoma; Trypanosomiasis

2009
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.
    Bioorganic & medicinal chemistry letters, 2009, Jun-01, Volume: 19, Issue:11

    Topics: Animals; Antiparasitic Agents; Cell Line; Computer Simulation; Drug Design; Enzyme Inhibitors; Glutathione Reductase; Humans; NADH, NADPH Oxidoreductases; Quinazolines; Rats; Structure-Activity Relationship; Trypanosoma cruzi

2009
Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Animals; Antiprotozoal Agents; Cell Line; Eukaryota; Female; Inhibitory Concentration 50; Leishmania donovani; Mice; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Plasmodium falciparum; Rats; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2009
Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Animals; Benzimidazoles; Cell Line; Cell Survival; Chagas Disease; Glucose; Leishmania braziliensis; Leishmaniasis; Macrophages; Mice; Mitochondria; Oxidoreductases; Trypanocidal Agents; Trypanosoma cruzi

2009
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
    Bioorganic & medicinal chemistry, 2009, Oct-15, Volume: 17, Issue:20

    Topics: Animals; Antimalarials; Antineoplastic Agents; Indole Alkaloids; Mice; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship

2009
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.
    Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21

    Topics: Antimalarials; Antitubercular Agents; Benzothiazoles; Drug Design; Isoxazoles; Models, Molecular; Mycobacterium tuberculosis; Phenylacetates; Stereoisomerism; Structure-Activity Relationship; Trypanocidal Agents

2009
Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:12

    Topics: Animals; Benzoxazoles; Inhibitory Concentration 50; Macrophages; Mice; Molecular Structure; Organophosphorus Compounds; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi

2009
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Animals; Antiprotozoal Agents; Cell Line; Humans; Leishmania donovani; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Infections; Quinolines; Structure-Activity Relationship; Trypanosoma; Trypanosoma cruzi

2010
Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.
    Bioorganic & medicinal chemistry letters, 2010, Mar-15, Volume: 20, Issue:6

    Topics: Animals; Cell Line; Drug Discovery; Rats; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2010
Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:9

    Topics: Antiprotozoal Agents; Antitubercular Agents; Furans; Humans; Mycobacterium tuberculosis; Trypanosomatina

2010
Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.
    Journal of natural products, 2010, Aug-27, Volume: 73, Issue:8

    Topics: Animals; Antiprotozoal Agents; Leishmania donovani; Marine Biology; Nuclear Magnetic Resonance, Biomolecular; Oceans and Seas; Plasmodium falciparum; Porifera; Saponins; Steroids; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2010
QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:11

    Topics: Alkaloids; Animals; Antimalarials; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared

2010
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Alkynes; Antimalarials; Binding Sites; Cell Line, Tumor; Computer Simulation; Erythrocytes; Fatty Acid Synthase, Type II; Fatty Acids, Unsaturated; Humans; Kinetics; Liver; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins

2010
Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.
    Journal of natural products, 2011, Apr-25, Volume: 74, Issue:4

    Topics: Animals; Antiprotozoal Agents; Indole Alkaloids; Leishmania donovani; Molecular Structure; New Zealand; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Spermidine; Structure-Activity Relationship; Trypanosoma; Urochordata

2011
Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes).
    Journal of natural products, 2011, Apr-25, Volume: 74, Issue:4

    Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antineoplastic Agents; Bacteroidetes; Drug Screening Assays, Antitumor; Female; Humans; India; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Pyrroles; Quinolines

2011
3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.
    Journal of medicinal chemistry, 2011, May-26, Volume: 54, Issue:10

    Topics: Animals; Chemistry, Pharmaceutical; Cyclic N-Oxides; Drug Design; Electrons; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Mutagenicity Tests; Parasitemia; Quinoxalines; Toxicity Tests; Trypanocidal Agents; Trypanosoma cruzi

2011
Antimalarial β-carbolines from the New Zealand ascidian Pseudodistoma opacum.
    Journal of natural products, 2011, Sep-23, Volume: 74, Issue:9

    Topics: Animals; Antimalarials; Carbolines; Chloroquine; Drug Resistance; Molecular Structure; New Zealand; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Stereoisomerism; Urochordata

2011
Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Animals; Antimalarials; Antiprotozoal Agents; Drug Design; Inhibitory Concentration 50; Leishmania donovani; Malaria; Models, Chemical; Molecular Structure; Myoblasts; Oxazines; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridinium Compounds; Rats; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2011
Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).
    Bioorganic & medicinal chemistry letters, 2011, Nov-01, Volume: 21, Issue:21

    Topics: Animals; Antiprotozoal Agents; Drug Evaluation, Preclinical; Humans; Protozoan Infections

2011
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
    Journal of medicinal chemistry, 2011, Dec-08, Volume: 54, Issue:23

    Topics: Amines; Animals; Cells, Cultured; Chagas Disease; Leishmania donovani; Mice; Nitro Compounds; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2011
Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.
    Bioorganic & medicinal chemistry, 2011, Dec-15, Volume: 19, Issue:24

    Topics: Animals; Antimalarials; Benzimidazoles; Cell Line; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats

2011
Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles.
    European journal of medicinal chemistry, 2012, Volume: 48

    Topics: Animals; Antiprotozoal Agents; Cell Line; Eukaryota; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Protozoan Infections; Pyrroles; Rats; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triazoles

2012
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
    Bioorganic & medicinal chemistry, 2012, Feb-15, Volume: 20, Issue:4

    Topics: Antimalarials; Antitubercular Agents; Coumarins; Dimerization; Fatty Acids, Monounsaturated; Inhibitory Concentration 50; Leishmania donovani; Light; Molecular Structure; Plasmodium falciparum; Pyrones

2012
Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: Antimalarials; Benzamides; Imides; Leishmania donovani; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2012
Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Amides; Animals; Cell Line; Leishmania donovani; Nitro Compounds; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Rats; Structure-Activity Relationship; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2012
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.
    Bioorganic & medicinal chemistry letters, 2012, Oct-01, Volume: 22, Issue:19

    Topics: Alkynes; Animals; Antiprotozoal Agents; Cell Line; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Leishmania donovani; Macrophages; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Topoisomerase I Inhibitors; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2012
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
    Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23

    Topics: Animals; Leishmania donovani; Polyamines; Quinones; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2012
Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds.
    Bioorganic & medicinal chemistry letters, 2013, Jan-15, Volume: 23, Issue:2

    Topics: Acetamides; Animals; Antimalarials; Drug Discovery; Inhibitory Concentration 50; Malaria; Molecular Structure; Plasmodium falciparum; Spermine; Structure-Activity Relationship

2013
Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.
    Journal of medicinal chemistry, 2013, Feb-28, Volume: 56, Issue:4

    Topics: Alkaloids; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Indoles; Malaria; Mice; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Quinolines; Rats; Structure-Activity Relationship

2013
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
    Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13

    Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inbred Strains; Models, Chemical; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma cruzi

2013
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
    European journal of medicinal chemistry, 2013, Volume: 66

    Topics: Anilides; Animals; Humans; Mice; Myoblasts, Skeletal; Rats; Species Specificity; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2013
Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.
    Journal of medicinal chemistry, 2013, Sep-26, Volume: 56, Issue:18

    Topics: Antiprotozoal Agents; Biological Products; Chemistry Techniques, Synthetic; Chromans; Inhibitory Concentration 50; Structure-Activity Relationship

2013
Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.
    Bioorganic & medicinal chemistry, 2013, Nov-01, Volume: 21, Issue:21

    Topics: Animals; Benzothiazoles; Cell Line; Cell Survival; Leishmania donovani; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2013
In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Animals; Antiprotozoal Agents; Benzene; Cell Line; Computer Simulation; Drug Design; Female; Humans; Leishmania; Mice; Structure-Activity Relationship; Sulfonamides; Trypanosoma cruzi

2013
New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
    ACS medicinal chemistry letters, 2013, Jun-13, Volume: 4, Issue:6

    Topics:

2013
Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.
    Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15

    Topics: Animals; Benzamides; Cell Line; HEK293 Cells; Humans; Microsomes, Liver; Myoblasts; Pyridines; Rats; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense

2014
Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi.
    European journal of medicinal chemistry, 2014, Sep-12, Volume: 84

    Topics: Antiparasitic Agents; Benzimidazoles; Cells, Cultured; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Leishmania donovani; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma cruzi

2014
Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila.
    Journal of natural products, 2014, Aug-22, Volume: 77, Issue:8

    Topics: Chromatography, High Pressure Liquid; Dipeptides; Leishmania; Molecular Structure; Multigene Family; Nuclear Magnetic Resonance, Biomolecular; Parasitic Sensitivity Tests; Plasmodium falciparum; Trypanosoma brucei brucei; Tryptamines; Xenorhabdus

2014
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
    Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19

    Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Parasitic Sensitivity Tests; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense

2014
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Amides; Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Leishmania donovani; Leishmaniasis, Visceral; Molecular Structure; Monocytes; Platelet Activation; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2014
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Animals; Antimalarials; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Malaria; Mice; Parasites; Plasmodium falciparum; Protein Isoforms

2015
Antiprotozoal activity and DNA binding of dicationic acridones.
    Journal of medicinal chemistry, 2015, Feb-26, Volume: 58, Issue:4

    Topics: Acridines; Acridones; Antiprotozoal Agents; Binding Sites; Cations; DNA; Dose-Response Relationship, Drug; Leishmania donovani; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2015
Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula.
    Journal of natural products, 2015, May-22, Volume: 78, Issue:5

    Topics: Alkaloids; Animals; Brazil; Guanidines; Leishmania infantum; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Parasitic Sensitivity Tests; Porifera; Pyrimidines; Trypanosoma cruzi

2015
2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.
    Journal of medicinal chemistry, 2015, Aug-27, Volume: 58, Issue:16

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Leishmania donovani; Mice; Mitochondria; Naphthoquinones; Small Molecule Libraries; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2015
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
    Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19

    Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2015
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2015
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Imidazoles; Leishmania donovani; Leishmaniasis, Visceral; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Plasmodium falciparum; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis

2016
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
    Bioorganic & medicinal chemistry letters, 2016, Feb-15, Volume: 26, Issue:4

    Topics: Antiprotozoal Agents; Leishmania infantum; Oils, Volatile; Phenols; Piperaceae; Plant Leaves; Structure-Activity Relationship; Trypanosoma cruzi

2016
In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.
    European journal of medicinal chemistry, 2016, May-04, Volume: 113

    Topics: Antiprotozoal Agents; Cell Line; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibroblasts; Humans; Imidazoles; Molecular Docking Simulation; Molecular Structure; Parasitic Sensitivity Tests; Phenylethyl Alcohol; Structure-Activity Relationship; Trypanosoma cruzi

2016
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.
    European journal of medicinal chemistry, 2016, Jul-19, Volume: 117

    Topics: Amides; Antiprotozoal Agents; Cell Line; Chagas Disease; Humans; Leishmania; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma

2016
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
    European journal of medicinal chemistry, 2016, Nov-10, Volume: 123

    Topics: Acetamides; Animals; Mice; Nitroreductases; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis, African

2016
Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes.
    Journal of natural products, 2016, 09-23, Volume: 79, Issue:9

    Topics: Alkaloids; Animals; Guanidines; Leishmania infantum; Marine Biology; Molecular Structure; Nitric Oxide; Porifera; Trypanosoma cruzi

2016
Dioncophyllines C
    Journal of natural products, 2017, 02-24, Volume: 80, Issue:2

    Topics: Alkaloids; Antimalarials; Antineoplastic Agents; Humans; Isoquinolines; Magnoliopsida; Molecular Structure; Multiple Myeloma; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Structure-Activity Relationship

2017
Synthesis and activity of nucleoside-based antiprotozoan compounds.
    Bioorganic & medicinal chemistry, 2017, 04-01, Volume: 25, Issue:7

    Topics: Animals; Antiprotozoal Agents; Carbon-13 Magnetic Resonance Spectroscopy; Inhibitory Concentration 50; Leishmania donovani; Plasmodium falciparum; Proton Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Trypanosoma brucei brucei; Trypanosoma cruzi

2017
Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum.
    Bioorganic & medicinal chemistry letters, 2017, 08-01, Volume: 27, Issue:15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiprotozoal Agents; Drug Design; Female; Giardia lamblia; Giardiasis; Humans; Leishmania; Mice; Nitro Compounds; Protozoan Infections; Thiazoles; Trichomonas vaginalis; Trypanosoma cruzi

2017
Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.
    Bioorganic & medicinal chemistry letters, 2017, 09-01, Volume: 27, Issue:17

    Topics: Animals; Antiparasitic Agents; Benzyl Compounds; Dose-Response Relationship, Drug; Heterocyclic Compounds; Leishmania donovani; Molecular Structure; Myoblasts; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2017
Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros.
    Journal of natural products, 2017, 09-22, Volume: 80, Issue:9

    Topics: Animals; Antiprotozoal Agents; Furans; Magnetic Resonance Spectroscopy; Molecular Structure; Porifera; Sesquiterpenes; Spectroscopy, Fourier Transform Infrared

2017
Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Pyrones; Structure-Activity Relationship; Trypanosoma cruzi

2017
Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line.
    Journal of natural products, 2017, 10-27, Volume: 80, Issue:10

    Topics: Algorithms; Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Congo; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoquinolines; Leishmania donovani; Magnoliopsida; Molecular Structure; Naphthalenes; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Neoplasms; Plasmodium falciparum; Rats; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Tumor Cells, Cultured

2017
Novel triazine dimers with potent antitrypanosomal activity.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Animals; Antiprotozoal Agents; Cell Proliferation; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Drug Discovery; Fibroblasts; Humans; Leishmania infantum; Male; Mice; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2018
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.
    European journal of medicinal chemistry, 2018, Feb-25, Volume: 146

    Topics: Antiprotozoal Agents; Chagas Disease; Dose-Response Relationship, Drug; Humans; Macrophages; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiosemicarbazones; Trypanosoma

2018
Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.
    Journal of natural products, 2018, 04-27, Volume: 81, Issue:4

    Topics: Africa, Central; Alkaloids; Antimalarials; Antineoplastic Agents, Phytogenic; Antiparasitic Agents; Caryophyllales; Cell Line, Tumor; Humans; Isoquinolines; Naphthalenes; Plasmodium falciparum; Quinolines

2018
Phytochemical Study of Salvia leriifolia Roots: Rearranged Abietane Diterpenoids with Antiprotozoal Activity.
    Journal of natural products, 2018, 06-22, Volume: 81, Issue:6

    Topics: Abietanes; Antimalarials; Antiprotozoal Agents; Inhibitory Concentration 50; Leishmania donovani; Parasitic Sensitivity Tests; Phytochemicals; Plant Extracts; Plant Roots; Plasmodium falciparum; Salvia; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2018
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Malaria, Falciparum; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African

2018
Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania donovani; Molecular Structure; Parasitic Sensitivity Tests; Quinoxalines; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi

2018
Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli.
    Journal of natural products, 2018, 10-26, Volume: 81, Issue:10

    Topics: Amino Acids; Animals; Antineoplastic Agents; Antiparasitic Agents; Escherichia coli; Methionine; Multigene Family; Oligopeptides; Parasites; Rats; Xenorhabdus

2018
Antiprotozoal Isoprenoids from Salvia hydrangea.
    Journal of natural products, 2018, 12-28, Volume: 81, Issue:12

    Topics: Animals; Antiprotozoal Agents; Cell Line; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plasmodium falciparum; Rats; Salvia; Spectrum Analysis; Terpenes; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2018
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Animals; Antiprotozoal Agents; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Parasitic Sensitivity Tests; Trypanosoma

2019
Synthesis and antimicrobial activities of N
    Bioorganic & medicinal chemistry, 2019, 02-15, Volume: 27, Issue:4

    Topics: Anti-Bacterial Agents; Biofilms; Candida albicans; Cell Line; Diterpenes; Escherichia coli; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrimidines; Staphylococcus aureus; Trypanosomatina

2019
Nongenotoxic 3-Nitroimidazo[1,2-
    ACS medicinal chemistry letters, 2019, Jan-10, Volume: 10, Issue:1

    Topics:

2019
Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model.
    Bioorganic & medicinal chemistry, 2019, 03-01, Volume: 27, Issue:5

    Topics: Animals; Chagas Disease; Chlorocebus aethiops; Cyclobutanes; DNA; Female; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; RNA; Splenomegaly; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2019
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
    Journal of medicinal chemistry, 2019, 04-25, Volume: 62, Issue:8

    Topics: Animals; Antiprotozoal Agents; Benzothiazoles; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Half-Life; Leishmania major; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Oxidoreductases; Protozoan Proteins; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosomiasis

2019
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Animals; Antiprotozoal Agents; Cricetinae; Drug Evaluation, Preclinical; Drug Resistance; Flavonols; Genomics; Humans; Leishmania; Leishmaniasis; Phosphorylcholine; Thiophenes

2019
Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana
    Journal of natural products, 2019, 11-22, Volume: 82, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antiprotozoal Agents; Caryophyllales; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Leishmania; Molecular Structure; Naphthalenes; Pancreatic Neoplasms; Plant Components, Aerial; Plant Leaves; Plasmodium; Rats; Trypanosoma

2019
Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives.
    Bioorganic & medicinal chemistry, 2020, 01-01, Volume: 28, Issue:1

    Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Isothiocyanates; Leishmania donovani; Molecular Docking Simulation; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2020
Structure, Biosynthesis, and Bioactivity of Photoditritide from
    Journal of natural products, 2019, 12-27, Volume: 82, Issue:12

    Topics: Anti-Bacterial Agents; Antiprotozoal Agents; Microbial Sensitivity Tests; Micrococcus luteus; Molecular Structure; Photorhabdus; Spectrum Analysis; Trypanosoma brucei rhodesiense

2019
Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids.
    European journal of medicinal chemistry, 2020, Sep-01, Volume: 201

    Topics: Hep G2 Cells; Humans; Leishmania infantum; Molecular Structure; Oxadiazoles; Oxindoles; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2020
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Dose-Response Relationship, Drug; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2020
Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents.
    European journal of medicinal chemistry, 2021, Feb-15, Volume: 212

    Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania infantum; Molecular Structure; Nucleosides; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi

2021
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
    European journal of medicinal chemistry, 2021, Apr-15, Volume: 216

    Topics: Cell Line; Cell Survival; Humans; Purine Nucleosides; Purines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2021
Revisiting Pyrazolo[3,4-
    Journal of medicinal chemistry, 2021, 04-08, Volume: 64, Issue:7

    Topics: Animals; Chagas Disease; Drug Design; Drug Stability; Humans; Leishmania infantum; Male; Mice; Microsomes, Liver; Molecular Structure; Nucleosides; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2021
Spirombandakamine A
    Journal of natural products, 2021, 04-23, Volume: 84, Issue:4

    Topics: Alkaloids; Animals; Antiprotozoal Agents; Caryophyllales; Cell Line; Democratic Republic of the Congo; Isoquinolines; Molecular Structure; Phytochemicals; Plant Leaves; Plasmodium falciparum; Rats; Trypanosoma brucei rhodesiense

2021
Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.
    Journal of medicinal chemistry, 2021, 05-13, Volume: 64, Issue:9

    Topics: Alkylation; Animals; Antimalarials; Benzopyrans; Biological Products; Biomimetic Materials; Chemistry Techniques, Synthetic; Erythrocytes; Kinetics; Mice; Plasmodium; Structure-Activity Relationship

2021
Synthesis, in vitro antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles.
    European journal of medicinal chemistry, 2021, Oct-05, Volume: 221

    Topics: Antiprotozoal Agents; Benzimidazoles; Cations; Dose-Response Relationship, Drug; Guanidine; Leishmania donovani; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

2021
N
    European journal of medicinal chemistry, 2022, Mar-05, Volume: 231

    Topics: Animals; Chagas Disease; Leishmania; Mice; Nucleosides; Purines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2022
Exploration of 6-methyl-7-(Hetero)Aryl-7-Deazapurine ribonucleosides as antileishmanial agents.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Animals; Antiprotozoal Agents; Cricetinae; Leishmania; Leishmaniasis; Mice; Nucleosides; Purine Nucleosides; Purines; Ribonucleosides

2022
Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:11

    Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Resistance; Exudates and Transudates; Inflammation; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitroimidazoles; omega-N-Methylarginine; Phosphorylcholine; Survival Analysis; Trypanosoma cruzi; Tumor Necrosis Factor-alpha

2002
In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.
    Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:3

    Topics: Antiprotozoal Agents; Colombia; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Phosphorylcholine; Trypanosoma cruzi

2009
Nuclease activity and ultrastructural effects of new sulfonamides with anti-leishmanial and trypanocidal activities.
    Parasitology international, 2012, Volume: 61, Issue:4

    Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Deoxyribonucleases; Leishmania infantum; Macrophages; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Molecular Structure; Nitroimidazoles; Phosphorylcholine; Sulfonamides

2012
In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi.
    International journal for parasitology. Drugs and drug resistance, 2017, Volume: 7, Issue:1

    Topics: Animals; Animals, Wild; Australia; Cell Line; Drug Discovery; High-Throughput Screening Assays; Inhibitory Concentration 50; Melarsoprol; Nitroimidazoles; Phosphorylcholine; Potoroidae; Pyrimidines; Triazoles; Trypanocidal Agents; Trypanosoma; Trypanosoma cruzi

2017
Miltefosine and Benznidazole Combination Improve Anti-
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Phosphorylcholine; Trypanocidal Agents; Trypanosoma cruzi

2022