benzonidazole has been researched along with azomycin in 868 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (10.25) | 18.7374 |
| 1990's | 64 (7.37) | 18.2507 |
| 2000's | 163 (18.78) | 29.6817 |
| 2010's | 427 (49.19) | 24.3611 |
| 2020's | 125 (14.40) | 2.80 |
| Authors | Studies |
|---|---|
| Castro, JA; de Castro, CR; Diaz de Toranzo, EG | 1 |
| Ndarathi, CM | 1 |
| da Silva, JS; Souza, SC; Takahashi, CS | 1 |
| Frasch, AC; Jazín, EE; Luquetti, AO; Rassi, A | 1 |
| Andrade, SG; Freitas, LA; Peyrol, S; Pimentel, AR; Sadigursky, M | 1 |
| Barbieri, GP; Gorla, NB; Larripa, IB; Ledesma, OS | 2 |
| Córdoba, JC; Solórzano, E; Souto Maior, I; Teixeira, AR | 1 |
| Gallerano, RH; Marr, JJ; Sosa, RR | 1 |
| Cunha Neto, E; Rizzo, LV; Silva, R; Teixeira, AR | 1 |
| Antunes-Rodrigues, J; Favaretto, AL; Lamano-Carvalho, TL; Vieira, CL | 1 |
| Cunha Neto, E; Rizzo, LV; Santana, JM; Silva, R; Teixeira, AR | 1 |
| Kaminsky, R; Sayer, PD; van Nieuwenhove, S; Zweygarth, E | 1 |
| Alves, MJ; Augusto, O; Brener, Z; Colli, W; Tsuhako, MH | 1 |
| Lazcano, F; Passalacqua, W; Thambo, S; Van Cauwelaert, R | 1 |
| Bleehen, NM; Freedman, LS; Stenning, SP | 1 |
| Aldunate, J; Letelier, ME; Moncada, C; Morello, A; Repetto, Y | 1 |
| Goijman, SG; Stoppani, AO | 2 |
| Dubin, M; Goijman, SG; Stoppani, AO | 2 |
| Antunes-Rodrigues, J; Barreira, AA; Favaretto, AL; Lamano-Carvalho, TL; Valença, MM; Vieira, CL | 1 |
| Cazzulo, JJ; Gonzalez, NS | 1 |
| Walton, MI; Wolf, CR; Workman, P | 1 |
| Bleehen, NM; Walton, MI; Workman, P | 2 |
| Bernacchi, AS; Carbone, M; Castro, JA; de Castro, CR; de Toranzo, EG | 1 |
| Hof, H | 1 |
| Moreno, SN | 1 |
| Docampo, R; Moreno, SN | 1 |
| Castro, JA; Cazzulo, JJ; Díaz de Toranzo, EG; Franke de Cazzulo, BM | 1 |
| Neal, RA; van Bueren, J | 1 |
| de Rezende, JM; de Souza, AA; Luquetti, AO; Miles, MA; Póvoa, MM; Rassi, A; Rodrigues, I | 1 |
| De Melo-Souza, SE; Defaria, CR; Rassi, A | 1 |
| Walton, MI; Workman, P | 1 |
| de Arruda Júnior, ER | 1 |
| Brener, Z; Filardi, LS | 2 |
| Moya, PR; Trombotto, GT | 1 |
| Castro, JA; Diaz de Toranzo, EG | 1 |
| Aldunate, J; Letelier, ME; Morello, A; Repetto, Y | 1 |
| Dische, S | 1 |
| Gutteridge, WE | 1 |
| de Melo, ME; Ferreira, LC; Ferreira, RC; Moraes Júnior, MA | 1 |
| Araujo, S; Riera de Narváez, AJ | 1 |
| Ferreira, LC; Ferreira, RC; Schwarz, U | 1 |
| Apt, W; Arab, F; Arribada, A; Luksic, I; Solé, C; Ugarte, JM | 1 |
| Aguilar, E; Castro, JA; de Arranz, CK; de Toranzo, EG | 1 |
| Ferreira, LC; Ferreira, RC | 1 |
| Nagel, R | 1 |
| Gorla, NB | 1 |
| Cheeseman, KH; Lee, FY; Workman, P | 1 |
| Aguilar, EG; Castro, JA; de Toranzo, EG; Koldobsky, C | 1 |
| Castro, JA; Díaz Gómez, MI; Gorla, N | 1 |
| Workman, P | 1 |
| Bleehen, NM; Newman, HF; Roberts, JT | 1 |
| Bernacchi, AS; Castro, JA; de Castro, CR; de Toranzo, EG | 1 |
| Aguilar, EG; Castro, JA; de Arranz, CK; de Toranzo, EG | 1 |
| Moore, DE | 1 |
| Frasch, AC; Goijman, SG; Stoppani, AO | 3 |
| Apt, W | 2 |
| Andrade, SG; Magalhães, JB; Pontes, AL | 1 |
| Gallerano, RH; Meirovich, CI; Montrull, HL; Sosa, RR | 1 |
| Lee, FY; Walton, MI; Workman, P | 1 |
| Bleehen, NM; Roberts, JT | 1 |
| Castro, GD; Castro, JA | 1 |
| Castro, JA; Gorla, NB | 1 |
| Kandaiya, S | 1 |
| Castro, JA; de Toranzo, EG; Masana, M; Rubio, M | 1 |
| Raaflaub, J; Richle, RW | 1 |
| Masana, MI; Rubio, MC | 1 |
| Barnabe, C; Dujardin, JP; Tibayrenc, M | 1 |
| Brown, JM; Hazlehurst, JL; Hirst, DG | 1 |
| Lee, FY; Workman, P | 1 |
| Docampo, R; Leon, W; Mason, RP; Moreno, SN; Stoppani, AO | 1 |
| Raether, W; Seidenath, H | 1 |
| Docampo, R; Moreno, SN; Stoppani, AO | 1 |
| Cabeza Meckert, P; Chambó, JG; Gelpi, R; Laguens, RP | 1 |
| Carpintero, DJ | 1 |
| Castro, JA; de Toranzo, EG; Masana, M | 4 |
| Manigot, DA | 1 |
| Pérez Lloret, A; Roldán, EJ | 1 |
| Owen, LN; Twentyman, PR; Walton, MI; White, RA; Workman, P | 1 |
| Bleehen, NM; Lee, FY; Roberts, JT; Walton, MI; Workman, P | 1 |
| Maddison, K; Siemann, DW; Wolf, K | 1 |
| Hodgkiss, RJ; Jones, NR; Sehmi, DS; Watts, ME; Woodcock, M | 1 |
| Raaflaub, J | 1 |
| Barrett, PA; Beveridge, E; Bull, D; Caldwell, IC; Islip, PJ; Neal, RA; Woods, NC | 1 |
| Abitbol, H | 1 |
| Brener, Z; Cançado, JR; Krettli, AU | 1 |
| Rassi, A | 1 |
| Almuna, R; Capetillo, M; Gottlieb, B; Reyes, H; Salgado, E | 1 |
| Morrissey, S; Siemann, DW; Wolf, K | 1 |
| Twentyman, PR; Workman, P | 1 |
| Hochmann, A; Lambert, PH; Poltera, AA | 1 |
| Barousse, AP; Cabrera, H; Laplumé, H | 1 |
| Natarajan, AT; Santos, SJ; Takahashi, CS | 1 |
| Lacava, ZG; Luna, H | 1 |
| Calixto, MA; Teixeira, AR; Teixeira, ML | 1 |
| Marin-Neto, JA; Simões, MV; Soares, FA | 1 |
| Britto, C; Cardoso, MA; Hasslocher-Moreno, A; Morel, CM; Oelemann, W; Pirmez, C; Santoro, A; Vanni, CM; Wincker, P; Xavier, SS | 1 |
| Jardim, E; Takayanagui, OM | 1 |
| Almiron, M; Campetella, O; Frasch, AC; Ganzález Cappa, SM; Guillen, I; Leguizamón, MS; Russomando, G | 1 |
| Amato Neto, V; Gama-Rodrigues, J; Iriya, K; Mester, M; Okumura, M | 1 |
| de Castro, SL | 1 |
| Cancado, JR; Galvao, LM; Gazzinelli, RT; Krautz, G; Krettli, AU; Lima, PC; Scharfstein, J | 1 |
| Kirchhoff, LV | 1 |
| Armenti, H; Segura, E; Vigliano, C; Viotti, R | 1 |
| Acuña, G; Brengues, C; Cuny, G; Labarca, J; Muñoz, S; Oddó, D; Saavedra, H; Sepúlveda, C; Solari, A; Veas, F | 1 |
| Bellotti, G; Bocchi, EA; de Lourdes Higuchi, M; Fiorelli, A; Jatene, A; Kalil, J; Pilleggi, F; Stolf, N; Uip, D | 1 |
| Bogitsh, BJ; Carter, CE; Jones, MM; Lane, JE; Molenda, JJ; Rodrigues, RR; Singh, PK; Zimmerman, LJ | 1 |
| Barnabé, C; Larroque, C; Nirdé, P | 1 |
| Bogitsh, BJ; Carter, CE; Jones, MM; Lane, JE; Ribeiro-Rodrigues, R; Singh, PK; Suarez, CC | 1 |
| Almeida Silva, S; Almeida, IC; de Andrade, AL; de Andrade, JG; de Andrade, SS; de Oliveira, RM; Luquetti, A; Martelli, CM; Travassos, LR; Zicker, F | 1 |
| Agosin, M; Maya, JD; Morello, A; Opazo, E; Repetto, Y | 1 |
| Docampo, R; Turrens, JF; Watts, BP; Zhong, L | 1 |
| Bestetti, RB | 2 |
| Almirón, M; Campetella, O; Frasch, AC; González-Cappa, SM; Leguizamón, MS; Luquetti, A; Rassi, A; Russomando, G | 1 |
| Agosín, M; Gaule, C; Maya, JD; Morello, A; Ojeda, JM; Repetto, Y; Tellez, R | 1 |
| Añez, N; Carrasco, HA; Fuenmayor, C; Inglessis, I; Parada, H | 1 |
| Barreira, AA; Flores-Vieira, CL | 1 |
| Barreira, AA; Chimelli, L; Flores-Vieira, CL; França Fernandes, RM | 1 |
| Billaut-Mulot, O; Fernandez-Gomez, R; Ouaissi, A | 1 |
| Borges, AS; Ferreira, MS; Nishioka, Sde A; Nunes-Araújo, FR; Rocha, A; Silvestre, MT | 1 |
| Murta, SM; Romanha, AJ | 1 |
| Bayo, R; Ceraso, D; De Rissio, A; Dengra, C; Dictar, M; Koziner, B; Luna, C; Riarte, A; Segura, E; Sinagra, A; Verón, MT | 1 |
| Bellotti, G; Bocchi, EA; Fiorelli, A; Higuchi, ML; Jatene, A; Pileggi, F; Stolf, N; Uip, D; Vieira, ML | 1 |
| Barnabé, C; Carrière, V; Laurent, JP; Noël, S; Oury, B; Quesney, V; Revollo, S; Tibayrenc, M | 1 |
| Brener, Z; Gazzinelli, RT; Murta, SM; Romanha, AJ | 1 |
| Acosta, N; Almiron, M; Calcena, MF; Candia, N; de Guillen, I; de Tomassone, MM; Figueredo, A; Russomando, G; Vera, N | 1 |
| Brener, Z; Carvalho-Oliveira, L; Ferreira, LR; Gazzinelli, RT; Michailowsky, V; Murta, SM; Pereira, ME; Romanha, AJ | 1 |
| Porcel, BM; Ruiz, AM; Segura, EL; Sosa Estani, S; Velazquez, E; Yampotis, C | 1 |
| Moreno, SN; Yan, W | 1 |
| Kelly, JM; Meyer, DJ; Temperton, NJ; Wilkinson, SR | 1 |
| Buschiazzo, H; Marín, G; Schinella, G; Tournier, H; Zaidenberg, A | 1 |
| Rassi Júnior, A; Rassi, A | 1 |
| Allaoui, A; François, C; Guilvard, E; Ouaissi, A; Zemzoumi, K | 1 |
| Pays, JF | 2 |
| Arán, VJ; Cerecetto, H; Di Maio, R; Gómez Barrio, A; Muelas, S; Ochoa, C; Pérez, E; Seoane, G | 1 |
| Bottasso, O; Le Page, C; Piaggio, E; Revelli, S; Wietzerbin, J | 1 |
| Laucella, SA; Riarte, A; Segura, EL; Sosa, ES | 1 |
| Brener, Z; Loebenberg, D; Martins-Filho, O; Molina, J; Romanha, AJ; Urbina, JA | 1 |
| Alves, RO; Gazzinelli, RT; Murta, SM; Romanha, AJ; Ropert, C | 1 |
| Segura, EL; Sosa Estani, S | 1 |
| Cançado, JR | 1 |
| Amato Neto, V | 1 |
| Barbeira, PJ; Beatriz, ML; Silva, GM; Stradiotto, NR | 1 |
| Bonté, F; Ferreira, ME; Fournet, A; Lavault, M; Nakayama, H; Rojas de Arias, A; Samudio, M; Schinini, A; Torres de Ortiz, S; Vera de Bilbao, N | 1 |
| Blanco, SB; Chuit, R; Cura, EN; Flores, I; Garbarino, G; Gürtler, RE; Segura, EL; Tulián, L; Villalonga, JF | 1 |
| Araújo, MS; Brener, Z; Martins-Filho, OA; Pereira, ME | 1 |
| de Lima, AP; Gauthier, F; Juliano, L; Lalmanach, G; Scharfstein, J; Schmitz, V; Vannier-Santos, MA; Yong, V | 1 |
| da Silva Melo, P; Durán, N; Haun, M | 1 |
| Araújo-Jorge, TC; de Castro, SL; de Souza, AP; Olivieri, BP | 1 |
| Gómez-Barrio, A; Muelas-Serrano, S; Nogal-Ruiz, JJ | 1 |
| Castro, JA | 1 |
| Altclas, J; De Rissio, A; Feldman, L; Jaimovich, G; Luna, C; Milovic, V; Requejo, A; Riarte, A; Salgueira, C; Sinagra, A | 1 |
| Giovannoni, AG; Montero, A | 1 |
| Bottasso, OA; Piaggio, E; Pitashny, M; Revelli, SS; Roggero, E; Wietzerbin, J | 1 |
| Castro, JA; Diaz, EG; Montalto de Mecca, M; Rodriguez de Castro, C | 1 |
| Bottasso, O; Piaggio, E; Revelli, S; Sancéau, J; Serra, E; Wietzerbin, J | 1 |
| Anacleto, C; dos Santos, WG; Moreira, ES; Murta, SM; Nirdé, P; Romanha, AJ | 1 |
| De Bem, AF; Geremias, R; Locatelli, C; Pedrosa, RC; Wilhelm Filho, D | 1 |
| Bahia, MT; Carneiro, CM; Chiari, E; Lana, M; Tafuri, WL; Toledo, MJ; Veloso, VM | 1 |
| Ferreira, ME; Fournet, A; Nakayama, H; Rojas de Arias, A; Schinini, A; Torres, S; Vera de Bilbao, N | 1 |
| Andrade, SG; Andrade, ZA; Lima, ES | 1 |
| Prata, A | 1 |
| de Castro, SL; Rodriques Coura, J | 1 |
| Buschiazzo, H; de Alaniz, MJ; Marra, CA; Zaidenberg, A | 1 |
| Brett, AM; Ferreira, EI; La-Scalea, MA; Serrano, SH | 1 |
| Cerecetto, H; González, M | 1 |
| Alves, RO; Gazzinelli, RT; Murta, SM; Romanha, AJ; Ropert, C; Silva, JS | 1 |
| Antunes, AC; Bolli, Fv; Cecchini, FM; Fricke, D; Monte, TL; Oliveira, PP; Reboucas, RG | 1 |
| Bozza, MT; Freire-De-Lima, CG; Gibaldi, D; Heise, N; Mendonça-Previato, L; Previato, JO; Saraiva, VB | 1 |
| Ataide Soares, K; Bahia, MT; Carneiro, CM; Chiari, E; Galvão, LM; Guedes, PM; Lana, Md; Tafuri, WL; Veloso, VM | 1 |
| Bakas, L; Benavidez, P; Lopez, MO; Morilla, MJ; Romero, EL | 1 |
| Araújo-Jorge, T; Cotta-De-Almeida, V; Olivieri, BP | 1 |
| Bahia, MT; Barnabé, C; Carneiro, CM; de Lana, M; Martins-Filho, OA; Tafuri, WL; Tibayrenc, M; Toledo, MJ | 1 |
| Basombrío, MA; Nasser, JR; Segura, MA | 1 |
| Escario, JA; Fernández-Portillo, C; Gómez-Barrio, A; Le-Senne, A; Muelas-Serrano, S | 1 |
| Assreuy, J; Calixto, JB; Corrêa, R; Eger-Mangrich, I; Grisard, EC; Guzela, M; Lunardi, F; Rodrigues, AT; Santos, AR; Steindel, M | 1 |
| Cortés, MJ; Cuellar, MA; Diego Maya, J; Morello, A; Preite, MD; Salas, C | 1 |
| David, BA; Gage, JL; Kirst, HA; Naylor, SA; O'Neil, D; Smith, CK | 1 |
| Gallerano, RR; Sosa, RR | 1 |
| Castro, JA; de Castro, CR; de Ferreyra, EC; Díaz, EG; Fanelli, SL; Montalto de Mecca, M | 1 |
| Fragata-Filho, AA; Levy, AM; Pereira-Chioccola, VL; Rodrigues, MM; Schenkman, S | 1 |
| Bittencourt, Nde L; Chiari, E; de Araújo, SM; Gomes, ML; Nakamura, CV; Toledo, MJ | 1 |
| Baeza, I; Chena, MA; Elizondo, S; Nogueda, B; Rodríguez-Páez, L; Wong, C | 2 |
| Benavidez, PE; Lopez, MO; Morilla, MJ; Romero, EL | 1 |
| Araujo, G; Armenti, A; de Rissio, AM; Lococo, B; Ruiz Vera, B; Segura, EL; Sosa-Estani, S; Vigliano, C; Viotti, R | 1 |
| Alves, CF; Bahia, MT; Carneiro, CM; Cruz, RE; Lana, M; Machado-Coelho, GL; Martins, HR; Tafuri, WL; Toledo, MJ; Veloso, VM | 1 |
| Ferreira, J; Maya, JD; Morello, A; Pabón, A; Pavani, M; Pino, L; Repetto, Y; Rodríguez, A | 1 |
| Barbosa, RA; Bello, V; Lobo, MC; Sousa, AA | 1 |
| Lopez, MO; Montanari, JA; Morilla, MJ; Petray, PB; Prieto, MJ; Romero, EL | 1 |
| Afonso, LC; Bahia, MT; Chiari, E; de Lana, M; Guedes, PM; Machado-Coelho, GL; Tafuri, WL; Urbina, JA; Veloso, VM | 1 |
| Amigorena, S; Bottasso, O; Guermonprez, P; Nocito, AL; Pascutti, MF; Pitashny, M; Revelli, S; Serra, E; Wietzerbin, J | 1 |
| Aires, AI; Almeida, IC; Andrade, AL; Andrade, JG; Covas, DT; Martelli, CM; Oliveira, RM; Silva, LS; Silva, SA; Soussumi, LM; Travassos, LR | 1 |
| Faundez, M; Ferreira, J; Letelier, P; López, R; Maya, JD; Morello, A; Ortiz, C; Pavani, M; Pino, L; Seguel, C | 1 |
| Escario, JA; Gómez-Barrio, A; Martínez-Fernández, AR; Rolón, M; Vega, C | 1 |
| Campos-de-Carvalho, AC; Garcia, S; Ramos, CO; Ribeiro-Dos-Santos, R; Rodrigues, MM; Senra, JF; Soares, MB; Vilas-Boas, F | 1 |
| Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA | 1 |
| Roldán, EJ | 1 |
| Araujo-Jorge, TC; Cotta-de-Almeida, V; Farias-De-Oliveira, DA; Olivieri, BP | 1 |
| Brengio, SD; Burgos, MH; Giordano, O; Jimenez-Ortiz, V; Sánchez, M; Sosa, MA; Tonn, C | 1 |
| Altclas, J; De Rissio, AM; Dictar, M; García, MM; Luna, C; Riarte, A; Salgueira, C; Sinagra, A; Verón, MT | 1 |
| Barnabé, C; Hide, M; Nirdé, P; Tibayrenc, M; Villarreal, D | 1 |
| Morilla, MJ; Prieto, MJ; Romero, EL | 1 |
| Castro-Prado, MA; Kaneshima, EN | 1 |
| Colmenarez-Mendoza, HJ; Dávila-Spinetti, DF; Lobo-Vielma, L | 1 |
| Alvarez, MG; Armenti, A; Bertocchi, G; Lococo, B; Petti, M; Vigliano, C; Viotti, R | 2 |
| Reyes, PA; Vallejo, M | 1 |
| Althabe, F; Belizan, JM; Rubinstein, A; Sosa-Estani, S | 1 |
| Bassani, G; Lamas, MC; Leonardi, D; Nocito, I; Pascutti, F; Salomón, CJ; Serra, E; Villaggi, L | 1 |
| González, P; González-Coloma, A; Illana, A; Longoni, SS; Marín, C; Mateo, H; Reina, M; Rodríguez-González, I; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Avila, AR; Bruna-Romero, O; Campos, FF; de Oliveira, RC; Goldenberg, S; Krieger, MA; Montenegro, LR; Murta, SM; Muto, NH; Nirdé, P; Nunes, LR; Probst, CM; Romanha, AJ | 1 |
| Alonso-Vega, C; Córdova, M; Suárez, E; Torrico, F | 1 |
| Escario, JA; Gómez-Barrio, A; Rolón, M; Vega, C | 1 |
| Chiari, E; de Castro, AM; Galvão, LM; Luquetti, AO; Rassi, A | 1 |
| Weir, E | 1 |
| Araújo-Jorge, T; Cotta-de-Almeida, V; de Castro, SL; de Souza, AP; Olivieri, BP | 1 |
| Bleiz, J; Buschiazzo, H; Del Buono, MB; Drut, R; Kozubsky, L; Lirussi, D; Luong, T; Marron, A; Quijano, G; Zaidenberg, A | 1 |
| Cassels, BK; Faúndez, M; Ferreira, A; Ferreira, J; Galanti, N; Iturriaga-Vásquez, P; Maya, JD; Morello, A | 1 |
| Alvarez, MG; Armenti, A; Bertocchi, G; Lococo, B; Petti, M; Postan, M; Vigliano, C; Viotti, R | 1 |
| Pinto Dias, JC | 1 |
| Bartel, LC; Castro, JA; de Mecca, MM | 2 |
| de Arias, AR; de Bilbao, NV; Ferreira, ME; Fournet, A; Hocquemiller, R; Lagoutte, D; Nakayama, H; Poupon, E; Schinini, A; Serna, E; Soriano-Agatón, F | 1 |
| Bastrenta, B; Bosseno, MF; Brenière, SF; Dalenz, JL; Flores-Chavez, M; Hontebeyrie, M; Revollo, S | 1 |
| Borges, JD; Dias, JC; Elói-Santos, SM; Lana, M; Martins-Filho, OA; Massara, RL; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Goldenberg, S; Krieger, MA; Murta, SM; Nirdé, P; Nogueira, FB; Romanha, AJ | 1 |
| Horn, D; Kelly, JM; Prathalingham, SR; Wilkinson, SR | 1 |
| Copstein, JL; D'Albuquerque, LA; Filho, HL; Gonzalez, AM; Larrea, FI; Mansero, JM; Oliveira e Silva, A; Perón, G; Ribeiro, MA | 1 |
| Alves, RO; Ferraz, ML; Gazzinelli, RT; Romanha, AJ; Urbina, JA | 2 |
| Braz, LM; Gakiya, E; Ibrahim, KY; Lopes, MH; Nunes Westphalen, EV; Oliveira, OC; Sartori, AM; Shikanai-Yasuda, MA | 1 |
| Caetano, PK; Calvi, SA; de Carvalho, TB; Lima, CR; Machado, JM; Nagoshi, LR; Persi, E; Picka, MM; Ribeiro, DA; Salvadori, DM | 1 |
| Del Bigio, MR; Nijjar, SS | 1 |
| Cunha-Neto, E; Maciel, BC; Marin-Neto, JA; Simões, MV | 1 |
| Bustamante, JM; Enders, JE; Fernández, AR; Fretes, RE; Paglini-Oliva, P; Presti, MS; Rivarola, HW | 1 |
| Albajar-Viñas, P; Gimena, B; González-Mediero, G; Martínez-Vázquez, C; Román, F; Sopeña, B; Sousa, J | 1 |
| Bahk, TJ; Daniels, MD; Engman, DM; Giafis, N; Hyland, KV; Leon, JS; Wang, K; Woods, LM | 1 |
| Barbosa, LR; Caetano, W; Hsu, HW; Itri, R; Pessoa, A; Rangel-Yagui, CO; Tavares, LC | 1 |
| Aguirre-Alvarado, C; Baeza, I; Nogueda, B; Rodríguez-Páez, L; Wong, C; Zaragoza-Martínez, F | 1 |
| de Lana, M; de Ornelas Toledo, MJ | 1 |
| Bahia, MT; Carneiro, CM; Lana, M; Macedo, AM; Machado-Coelho, GL; Martins, HR; Martins-Filho, OA; Silva, RM; Toledo, MJ; Valadares, HM; Veloso, VM; Vitelli-Avelar, DM | 1 |
| Corachan, M; Fumadó, V; Gascon, J; Muñoz, J; Portús, M | 1 |
| de Andrade, HM; Murta, SM; Nirdé, P; Nogueira, FB; Rego, JV; Romanha, AJ | 1 |
| Doyle, PS; Engel, JC; McKerrow, JH; Zhou, YM | 1 |
| Guañabens, N; Moll, C; Moreno, A; Muñoz, J; Peris, P | 1 |
| Alejandre-Aguilar, R; Gómez-Garcia, L; León-Pérez, F; López, R; Monteón, VM | 1 |
| Jannin, J; Villa, L | 1 |
| El Masri, M; Karcz, DA; Lennox, HA; Tales, H | 1 |
| Bahia, MT; Caldas, S; de Lana, M; Diniz, LF; Machado-Coelho, GL; Santos, FM; Veloso, VM | 1 |
| de Lana, M; Elói-Santos, SM; Martins-Filho, OA; Massara, RL; Pinto Dias, JC; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Bahia, MT; Carneiro, CM; Figueiredo, LM; Lana, M; Macedo, AM; Machado-Coelho, GL; Martins, HR; Martins-Filho, OA; Valamiel-Silva, JC; Vitelli-Avelar, DM | 1 |
| Cheeseman, I; Horn, D; Kelly, JM; Taylor, MC; Wilkinson, SR | 1 |
| Ajana, F; Bonnard, P; Canestri, A; Carlier, Y; Danis, M; Develoux, M; Dorent, R; Elghouzzi, MH; Gay, F; Guiard-Schmid, JB; Jauréguiberry, S; Lescure, FX; Melliez, H; Pialoux, G; Rolla, V | 1 |
| Bixby, LM; Bustamante, JM; Tarleton, RL | 1 |
| Andrade, HM; Chapeaurouge, A; Murta, SM; Nirdé, P; Perales, J; Romanha, AJ | 1 |
| Aleixo, DL; Araújo, SM; Bersani-Amado, CA; de Melo, CS; Ferraz, FN; Gomes, ML; Kaneshima, EN; Toledo, MJ | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Carneiro, CM; da Matta Guedes, PM; de Lana, M; Talvani, A | 1 |
| Castro-E-Silva, O; Figueiredo, JF; Gaspar, GG; Maciel, BC; Marin Neto, JA; Martinelli, AL; Melo, L; Passos, AD; Romano, MM; Rossi, MA; Sankarankutty, AK; Souza, FF; Teixeira, AC | 1 |
| Campos, FM; Dos Santos, PF; Goldenberg, S; Krieger, MA; Liarte, DB; Murta, SM; Nirdé, P; Nogueira, FB; Probst, CM; Romanha, AJ; Volpe, C | 1 |
| Barbosa, VA; Basso, EA; Bocca, CC; da Costa, WF; Nakamura, CV; Nakamura, TU; Ramos, ER; Sarragiotto, MH; Tonin, LT | 1 |
| Bahia, MT; de Araújo, SM; de Lana, M; de Ornelas Toledo, MJ; Gomes, ML; Marangon, AV; Martins-Filho, OA; Miyamoto, CT | 1 |
| Alves Lima, FC; Ferreira da Silva, AB; Gutierrez, FR; Nogueira Silva, JJ; Pavanelli, WR; Santana Silva, J; Wagner Franco, D | 1 |
| Avezum, A; Connolly, SJ; Marin-Neto, JA; Morillo, CA; Rassi, A; Rosas, F; Sosa-Estani, S; Yusuf, S | 1 |
| Arantes, JM; Bahia, MT; Carneiro, CM; de Abreu Vieira, PM; de Lana, M; Francisco, AF; Martins, HR; Pedrosa, ML; Silva, M; Tafuri, WL; Veloso, VM | 1 |
| Elói-Santos, SM; Faria, AM; Gontijo, ED; Martins-Filho, OA; Pinto Dias, JC; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| de Souza, JL; Ianni, BM; Mady, C | 1 |
| Bahia, MT; Caldas, S; Crepalde, GP; de Assis Cáu, SB; de Lana, M; Dos Santos, FM; Machado-Coelho, GL; Veloso, VM | 1 |
| Bahia, MT; de Lana, M; dos Santos, DM; Guedes, PM; Machado-Coelho, GL; Talvani, A | 1 |
| Lamas, MC; Leonardi, D; Olivieri, AC; Salomón, CJ | 1 |
| A, IZ; B, WA; G, IH; H, IN; H, MT; L, MI; M, LJ; P, JS; V, AM; V, PM | 1 |
| Bartel, LC; Castro, CR; Castro, JA; Mecca, MM | 1 |
| Mejía-Jaramillo, AM; Peña, VH; Triana-Chávez, O | 1 |
| Bottasso, E; Bottasso, O; Manarin, R; Revelli, S; Serra, E | 1 |
| Murta, SM; Nogueira, FB; Robello, C; Romanha, AJ; Ruiz, JC | 1 |
| Brun, R; Ma, X; Zhou, W | 1 |
| Gargiullo, G; Papayanis, C; Sica, RE | 1 |
| Altcheh, J; Della Védova, CO; Garcia-Bournissen, F; Giglio, N; Koren, G; Mastrantonio, G | 1 |
| Develoux, M; Le Loup, G; Lescure, FX; Pialoux, G | 1 |
| Branco, JN; Buffolo, E; Gaia, DF; Guilhen, JC; Palma, JH; Teles, A; Teles, CA | 1 |
| Cedillo-Rivera, R; Hernández-Núñez, E; Moo-Puc, R; Nava-Zuazo, C; Navarrete-Vazquez, G; Reyes-Martínez, R; Tlahuext, H; Torres-Gómez, H | 1 |
| Barretto Cicarelli, RM; Batista Junior, JM; da Silva Bolzani, V; da Silva Mota, J; Duó Passerini, G; Furlan, M; Kato, MJ; Leite, AC; Luz Ambrósio, D; Noelí López, S | 1 |
| Balbinot, MM; Fernandes, CD; Liarte, DB; Romanha, A; Scholl, D; Steindel, M; Tiecher, FM | 1 |
| Bottasso, O; Campodonico, G; García, F; Manarin, R; Pascutti, MF; Revelli, S; Serra, E | 1 |
| de Almeida, LV; Jorge, SD; Pasqualoto, KF; Paula, FR; Tavares, LC | 1 |
| Bestetti, RB; Theodoropoulos, TA | 1 |
| Ferreira, AG; Harada, GS; Pinto, AY; Valente, SA; Valente, Vda C | 1 |
| Alba Soto, CD; Fernández, MC; González Cappa, SM; Poncini, CV; Postan, M; Solana, ME | 1 |
| Alquichire, C; Diazgranados, CA; Franco-Paredes, C; Mantilla, M; Saavedra-Trujillo, CH; Valderrama, SL | 1 |
| Campos, FM; Liarte, DB; Mortara, RA; Murta, SM; Romanha, AJ | 1 |
| Albajar Viñas, P; Castillo, S; Chambi, W; Ellman, T; Flevaud, L; Lima, MA; Palma, PP; Parreño, F; Roddy, P; Yun, O | 1 |
| Budni, P; Colepicolo, P; Dalmarco, EM; Farias, MS; Filho, DW; Fröde, TS; Oliveira-Silva, D; Parisotto, EB; Pedrosa, RC; Ribeiro, CM | 1 |
| Altcheh, J; Bisio, M; Burgos, JM; Freilij, H; Levin, MJ; Petrucelli, N; Schijman, AG | 1 |
| Escanilla, S; Faúndez, M; Ferreira, A; Ferreira, J; Kemmerling, U; Klein, S; Lee-Liu, D; López-Muñoz, R; Maya, JD; Morello, A; Orellana, M; Torres, G | 1 |
| Fernández, MC; González Cappa, SM; Solana, ME | 1 |
| Avezum, A; Marin-Neto, JA; Mattos, AC; Morillo, CA; Rassi, A; Sosa-Estani, S; Yusuf, S | 1 |
| Fernández-González, MC; López-Velez, R; Moreno, S; Pérez-Ayala, A; Pérez-Molina, JA; Zamora, J | 1 |
| Bahia, MT; Caldas, IS; Carneiro, CM; Diniz, LF; Lana, M; Machado-Coelho, GL; Martins, TA; Oliveira, Rde P; Santos, DM; Talvani, A | 1 |
| Albareda, MC; Alvarez, MG; Armenti, A; Bertocchi, G; Cooley, G; Laucella, SA; Lococo, B; Mazliah, DP; Postan, M; Tarleton, RL; Viotti, R | 1 |
| Urbina, JA | 3 |
| Arán, VJ; Boiani, L; Carrasco-Pozo, C; Cerecetto, H; Cosoy, HS; González, M; Lavaggi, ML; Maya, JD; Olea-Azar, C; Rodríguez, J | 1 |
| Bowling, J; Walter, EA | 1 |
| Brutus, L; Chippaux, JP; Clavijo, AN; Postigo, JR; Santalla, JA; Schneider, D | 1 |
| Alves, RC; Barbosa, VS; Holanda, CM; Medeiros, AC; Rocha, LG; Silva, RP; Silva-Júnior, MF | 1 |
| Bassets, G; Escribà, JM; Lima, MA; Marchiol, A; Palma, PP; Ponce, C; Ponce, E; Romero, Ade D; Viñas, PA; Zúniga, C | 1 |
| Andrade, SG; Portella, RS | 1 |
| Bendhack, LM; da Silva, GK; da Silva, RS; Do Valle Matta, MA; Franco, DW; Guedes, PM; Gutierrez, FR; Oliveira, FS; Rodrigues, GJ; Silva, JS; Zamboni, DS | 1 |
| Ibrahim, K; Le Loup, G; Malvy, D | 1 |
| Albajar-Viñas, P; Bahia, MT; Coura, JR; Dias, JC; Lana, Md; Lopes, LA; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Montoya, RA; Wendling, AP | 1 |
| Bartel, LC; Bietto, FM; Castro, JA; de Castro, CR; Montalto de Mecca, M | 1 |
| Albuquerque, S; do Prado, JC; Kuehn, CC; Loria, RM; Oliveira, LG; Santos, CD; Toldo, MP | 1 |
| Holen, Ø | 1 |
| Machado, FS; Tanowitz, HB; Teixeira, MM | 1 |
| Bersani-Amado, CA; Cuman, RK; Gomes, ML; Marques-Araujo, S; Pupulin, AR; Takejima, E; Toledo, MJ | 1 |
| Croft, SL; Escobar, P; Hernández, IP; Luna, KP; Rueda, CM; Zorro, MM | 1 |
| Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA | 1 |
| Corrêa, RR; Correia, D; dos Reis, MA; Faleiros, AC; Guimarães, CS; Oliveira, FA; Ramirez, LE; Silva, AC; Silva, AE; Teixeira, AC; Teixeira, Vde P | 1 |
| Caires, AC; Matsuo, AL; Pascoalino, BS; Ramos, TC; Rodrigues, EG; Schenkman, S; Silva, LS; Torrecilhas, AC; Travassos, LR | 1 |
| Bua, J; Bustos, PL; Fichera, LE; Gonzalez, MN; Grosso, NL; Perrone, AE; Postan, M | 1 |
| Condon, D; Dhiman, M; Garg, NJ; Guan, Z; Gupta, S; Lui, C; Wen, JJ | 1 |
| Carrilero, B; Iborra, MA; Muñoz, MJ; Murcia, L; Segovia, M | 1 |
| Correia, D; Fuzissaki, J; Lages-Silva, E; Molina, RJ; Niederhaur, S; Oliveira, LF; Prata, A; Silva, VJ | 1 |
| Aras, R; Bastos, CJ; de Araújo, EG; de Jesus, RS; Dias, JP; Freire, MS; Grassi, MF; Mota, G; Prazeres, J; Reis, F | 1 |
| Basombrío, MA; Chung, MC; Davies, C; Marino Cardozo, R; Mora, MC; Sánchez Negrette, O | 1 |
| Clayton, J | 2 |
| Boscá, L; Bottasso, O; De Las Heras, B; Manarin, R; Pascutti, MF; Revelli, S; Ruffino, JP; Serra, E | 1 |
| Gascon, J; Muñoz, J; Oliveira, I; Torrico, F | 1 |
| Bocchi, EA; Issa, VS | 1 |
| Ayala, E; del Cacho, E; Gállego, M; Gascon, J; López-Chejade, P; Muñoz, J; Pinazo, MJ; Posada, E; Soy, D | 1 |
| Correia, LP; de La Roca Soares, MF; de Souza, FS; Lopes, PQ; Macêdo, RO; Rolim-Neto, PJ; Soares-Sobrinho, JL | 1 |
| Altcheh, J; Biancardi, M; Freilij, H; Liesenfeld, O; Mayer, JP; Weinke, T | 1 |
| Asensi, V; Miró, JM; Rodríguez-Guardado, A; Tuset, M | 1 |
| Dias Filho, BP; Izumi, E; Nakamura, CV; Pelizzaro-Rocha, KJ; Tiuman, TS; Ueda-Nakamura, T | 1 |
| Cañavate, C; Díaz-Menéndez, M; Flores, M; López-Vélez, R; Monge-Maillo, B; Navarro, M; Norman, F; Pérez-Ayala, A; Pérez-Molina, JA; Peris-García, J | 1 |
| Gascón, J; Guerrero, L; Pinazo, MJ; Posada, E; Ribas, J; Soy, D | 1 |
| Alsford, S; Baker, N; Horn, D | 1 |
| Chiari, E; D'ávila, DA; Galvão, LM; Gontijo, ED; Macedo, AM; Moreno, M; Silva, MN; Zingales, B | 1 |
| Altcheh, J; Freilij, H; Garcia-Bournissen, F; Moroni, S; Moscatelli, G | 1 |
| Ferreira, J; Kemmerling, U; López-Muñoz, R; Maya, JD; Morello, A; Orellana, M | 1 |
| Carnovale, C; Francés, D; Manarin, R; Revelli, S; Ronco, MT; Serra, E | 1 |
| Bahia, MT; Cunha-Filho, MS; de Andrade, IM; de Paula, LM; Figueiredo, VP; Maximiano, FP; Sá-Barreto, LC; Talvani, A | 1 |
| Arias, E; Bizai, ML; Bottasso, O; del Barco, M; Denner, S; Diez, C; Fabbro, DL; Mancipar, I; Marcipar, I; Mendicino, D; Olivera, V; Streiger, M | 1 |
| Corrêa-Júnior, RA; Hernandes, MZ; Lima, AA; Lyra, MA; Oliveira, BG; Rolim, LA; Rolim-Neto, PJ; Santos, FL; Silva, JL; Soares-Sobrinho, JL | 1 |
| Barea, E; Caballero, AB; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M | 1 |
| Beranger, C; Boulliat, C; Coilliot, C; Gaillard, K; Oliver, M; Rouault, M; Wolf, A | 1 |
| Bahia, MT; Costa, GH; Cunha-Filho, MS; de Sá Barreto, LC; Maximiano, FP | 1 |
| Guedes, PM; Gutierrez, FR; Silva, GK; Silva, JS | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Bulffer, RF; Castro, JA; Fanelli, SL | 1 |
| Bern, C | 2 |
| Carrilero, B; Fernández-Villegas, A; Gascon, J; López, MC; Marañón, C; Pinazo, MJ; Posada, E; Segovia, M; Thomas, MC | 1 |
| Batista, Dda G; Batista, MM; Boykin, DW; Britto, CC; de Oliveira, GM; Rodrigues, AC; Soeiro, Mde N; Stephens, CE | 1 |
| Ayala, E; Fisa, R; Gállego, M; Gascon, J; Monteagudo, J; Muñoz, J; Pinazo, MJ; Posada, Ede J; Reverter, JC; Tàssies, D | 1 |
| Fernández, GJ; Mejía-Jaramillo, AM; Palacio, L; Triana-Chávez, O | 1 |
| Akay, S; Banerjee, M; Boykin, DW; Correia Soeiro, MD; DA Silva, CF; DA Silva, PB; Daliry, A; Farahat, AA; Fisher, MK; Hu, L; Kumar, A; Liu, Z; Stephens, CE | 1 |
| Alvarez, MG; Armenti, A; Bertocchi, G; Cooley, G; De Rissio, AM; Laucella, S; Lococo, B; Petti, M; Tarleton, R; Vigliano, C; Viotti, R | 1 |
| Carrilero, B; Martínez-Lage, L; Murcia, L; Segovia, M | 1 |
| Aleixo, DL; de Araújo, SM; de Melo, CS; do Nascimento, A; Ferraz, FN; Gomes, ML; Simoni, GK; Spack, M | 1 |
| Dias Filho, BP; Kaneshima, EN; Nakamura, CV; Sarragiotto, MH; Silva, SO; Tonin, LT; Ueda-Nakamura, T; Valdez, RH; Yamada-Ogatta, SF; Yamauchi, LM | 1 |
| Hall, BS; Wilkinson, SR | 1 |
| Altcheh, JM; Cardoni, RL; Corral, RS; Cutrullis, RA; Freilij, HL; Moroni, S; Moscatelli, GF; Petray, PB; Volta, BJ | 1 |
| Salomon, CJ | 1 |
| Garg, NJ; Wen, JJ | 1 |
| Aguiar, C; Almeida, EA; Batista, AM; Costa, SC; Guariento, ME; Pavan, TB; Wanderley, JS | 1 |
| Buysschaert, I; De Keyser, J; Dujardin, K | 1 |
| Chambela, MC; de Sousa, AS; do Brasil, PE; Hasslocher-Moreno, AM; Sperandio da Silva, GM; Xavier, SS | 1 |
| Levy, MZ; Manne, J; Reich, MR; Snively, CS | 1 |
| Agil, A; Alvarez-Manzaneda, E; Chahboun, R; Es-Samti, H; Fernández, A; Guardia, JJ; Marín, C; Ramírez-Macías, I; Sánchez-Moreno, M; Zentar, H | 1 |
| Albesa, I; Becerra, MC; Gea, S; Guiñazú, N; Hergert, LY; Mazzieri, MR; Pellegrini, A | 1 |
| de Lana, M; de Souza, J; Moreira da Silva, R; Oliveira, LT; Silva Barcellos, NM | 1 |
| Albajar Viñas, P; Carrilero, B; Murcia, L; Segovia, M | 1 |
| Gómez-Palacio, A; Hall, BS; Kelly, JM; Mejia, AM; Taylor, MC; Triana-Chávez, O; Wilkinson, SR | 1 |
| Bahia, MT; Gravel, AS; Lima, WG; Martins, TA; Santos, FM; Talvani, A; Torres, RM | 1 |
| Albareda, MC; Alvarez, MG; Argüello, RJ; Armenti, AH; Bertocchi, G; Laucella, SA; Meckert, PC; Tarleton, RL; Vigliano, C | 1 |
| Ballesteros, LA; Basile, L; Rodrigo, C; Roure, S; Sabrià, M; Valerio-Sallent, L | 1 |
| Elói-Santos, SM; Gontijo, ED; Martins-Filho, OA; Sathler-Avelar, R; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Marcondes de Rezende, J; Rassi, A | 1 |
| Correa, MM; Murta, SM; Nogueira, FB; Rodrigues, JF; Romanha, AJ; Ruiz, JC | 1 |
| Bilbao-Ramos, P; Bolás-Fernández, F; Dea-Ayuela, MA; Galiana-Roselló, C; González-Alvarez, M; González-Rosende, ME; Pérez-Serrano, J; Rolón, M; Vega, C | 1 |
| Galimberti, RL; Maqueda, MG; Piñero, MC; Riganti, J; Volonteri, VI | 1 |
| Albajar-Viñas, P; Bahia, MT; Dias, JC; Do Bem, VA; Lana, M; Machado-de-Assis, GF; Martins-Filho, OA; Silva, AR; Torres, RM | 1 |
| Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL | 1 |
| Alvarez-Manzaneda, E; Chahboun, R; Gutierrez-Sánchez, R; Marín, C; Messouri, I; Olmo, F; Ramírez-Macías, I; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Burgos, LG; Canese, A; Melo, M; Ojeda, A; Ortiz, BD | 1 |
| López-Vélez, R; Navarro, M; Norman, FF; Pérez-Molina, JA | 1 |
| de Almeida, LR; de Souza, AS; Lannes-Vieira, J; Moreira, OC; Pereira, IR; Rocha, MS; Silva, AA; Silva, RR; Vilar-Pereira, G | 1 |
| Voelker, R | 1 |
| Batlle, A; Ciccarelli, AB; Frank, FM; Lombardo, ME; Malchiodi, EL; Puente, V | 1 |
| dos Santos, PF; Folador, EL; Moreira, DS; Murta, SM; Oliveira, G; Rezende, AM; Romanha, AJ; Ruiz, JC; Soares, RP | 1 |
| Cruz-Zetina, G; del Rio-Rodriguez, R; López, R; Monteon, V; Ramos-Ligonio, A | 1 |
| Alvarez, MG; Bertocchi, G; Lococo, B; Petti, M; Vigliano, C; Viotti, R | 1 |
| Hall, BS; Meredith, EL; Wilkinson, SR | 1 |
| Bottasso, E; Lamas, MC; Manarin, R; Revelli, S; Salomón, CJ; Serra, E | 1 |
| Britto, C; Guhl, F; Lima-Ferreira, C; Marin-Neto, JA; Melo, MF; Moreira, OC; Morillo, CA; Ramírez, JD; Sosa-Estani, S; Velázquez, E | 1 |
| Carlier, Y; Cencig, S; Coltel, N; Truyens, C | 1 |
| Caleare, Ade O; Cogo, J; Ferreira, IC; Filho, BP; Nakamura, CV; Ueda-Nakamura, T | 1 |
| Albareda, MC; Alvarez, MG; Armenti, AH; Bertocchi, G; Cooley, G; Laucella, SA; Lococo, BE; Perez-Mazliah, DE; Petti, M; Tarleton, RL; Viotti, R | 1 |
| Azevedo, MA; Bahia, MT; Caldas, IS; da Matta Guedes, PM; da Silva do Nascimento, AF; de Figueiredo Diniz, L; de Lima, WG; dos Santos, FM; Martins, TA; Neto, RM; Talvani, A; Torres, RM | 1 |
| Gascon, J; Guerrero, L; Pinazo, MJ; Posada, E; Rodríguez, E; Soy, D | 1 |
| Bahia, MT; Barbosa, MG; Bossolani, GD; de Araújo, SM; Gomes, ML; Monteiro, WM; Reis, D; Teston, AP; Toledo, MJ | 1 |
| Barrett, MP; Croft, SL | 1 |
| Amador, C; Arjona, FJ; Caro, E; Cuadrado, JM; Gallegos, I; Gutiérrez, F; Jover, F; Martínez-Peinado, C; Pérez-Chacón, F; Ponce, Y; Ramos, JM; Tello, A; Torrús, D | 1 |
| Fernández, GJ; Mejía-Jaramillo, AM; Montilla, M; Nicholls, RS; Triana-Chávez, O | 1 |
| Arias, A; Catania, VA; Luquita, MG; Mottino, AD; Perdomo, VG; Rigalli, JP; Ruiz, ML; Theile, D; Villanueva, SS; Weiss, J | 1 |
| Bastos, JK; Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; e Silva, ML; Esperandim, VR; Rezende, KC; Saraiva, J | 1 |
| Brutus, L; Chippaux, JP; Postigo, JR; Salas-Clavijo, AN; Santalla, JA; Schneider, D | 1 |
| Leonardi, D; Salomon, CJ | 1 |
| Bandyopadhyay, D; Banik, BK; Nogueda-Torres, B; Rivera, G; Samano, S; Sanchez-Torres, LE; Villalobos-Rocha, JC | 1 |
| Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J | 1 |
| Espinoza, B; Martínez, I; Martínez-Hernández, F; Nogueda, B | 1 |
| Baez, A; Bazán, PC; Cremonezzi, D; Esteves, B; Fauro, R; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Sanchez Negrete, O; Strauss, M | 1 |
| Alarcon, ML; Bua, J; Fichera, LE; Grosso, NL; Laucella, SA; Riarte, A | 1 |
| Chattopadhyaya, J; Dixit, SS; Földesi, A; Upadhayaya, RS | 1 |
| Campos-Estrada, C; Duaso, J; Ferreira, J; Galanti, N; Kemmerling, U; Lapier, M; Leiva, M; López-Muñoz, R; Maya, JD; Molina-Berríos, A | 1 |
| Bruballa, AC; De Rissio, AM; Garavaglia, PA; García, GA; Irazu, LE; Riarte, A; Rodríguez, MA; Ruiz, AM; Santamaría, AL | 1 |
| Berredo-Pinho, MM; Campos, MC; Castro-Pinto, DB; da Silva Bellieny, MS; Echevarria, A; Gomes, LH; Goulart, CM; Leon, LL; Ribeiro, GA | 1 |
| Albajar-Viñas, P; Díaz-Menéndez, M; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Sojo-Dorado, J | 1 |
| Altcheh, J; García-Bournissen, F; Marsón, ME; Mastrantonio, GE; Padró, JM; Reta, M | 1 |
| Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; do Prado Júnior, JC; e Silva, ML; Esperandim, VR; Kuehn, CC; Toldo, MP | 1 |
| Cabello, A; Fernández-Roblas, R; Górgolas, M; Peremarch, CP; Pérez-Tanoira, R; Rincón, JM; Robles, I; Williams, F | 1 |
| Coura, JR; de Macedo, RC; Ferreira, AG; Junqueira, AC; Pinto, AY; Santos, LC; Valente, SA; Valente, Vda C | 1 |
| Arias, E; Bizai, ML; Denner, S; Fabbro, D; Olivera, V; Pravia, C; Ruiz, AM; Velazquez, E | 1 |
| Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR | 1 |
| Anyanwu, A; Bosserman, E; Herwaldt, B; Huprikar, S; Ketterer, D; Montgomery, S; Moore, A; Neofytos, D; Patel, G; Pinney, S; Qvarnstrom, Y; Silveira, F; Steurer, F; Striker, R | 1 |
| Ávila, AR; Fidêncio, NJ; Fragoso, SP; Gradia, DF; Kessler, RL; Lourenço, ÉE; Manhaes, L; Pontello Rampazzo, Rde C; Probst, CM | 1 |
| da Silva, JS; de Souza, MC; Ferreira, VF; Leitão, A; Montanari, CA; Monteiro, PA; Santos, Fda C; Sesti-Costa, R; Soares, FA | 1 |
| Altcheh, J; García-Bournissen, F; Marson, ME; Mastrantonio, G; Padró, JM; Reta, MR | 1 |
| Calvo, KL; García, F; Noguera, NI; Ronco, MT | 1 |
| Alonso-Vega, C; Billot, C; Torrico, F | 1 |
| Catania, VA; Echenique, CG; Luquita, MG; Perdomo, VG; Rigalli, JP; Ruiz, ML; Villanueva, SS | 1 |
| Basombrío, MA; Cimino, RO; D'Amato, AM; Diosque, P; Gil, JF; Lacunza, CD; Lauthier, JJ; Nasser, JR; Orellana, V; Pérez Brandán, C; Ragone, PG; Rumi, MM; Tomasini, N | 1 |
| Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Kouznetsov, VV; Merchán Arenas, DR; Romero Bohórquez, AR | 1 |
| Ashworth, R; Bloomer, W; Buchanan-Kilbey, G; Djumpah, J; Hu, L; Papadopoulou, MV; Wilkinson, SR | 1 |
| Adams, M; Batista, Dda G; Batista, MM; Brun, R; da Silva, CF; da Silva, PB; De Araújo, JS; De Mieri, M; de Souza, EM; Hamburger, M; Hammer, ER; Lionel, J; Schühly, W; Soeiro, Mde N; Zimmermann, S | 1 |
| Fox, MC; Katz, JT; Lakdawala, N; Sircar, M; Vaidya, A | 1 |
| Bustamante, JM; Craft, JM; Crowe, BD; Ketchie, SA; Tarleton, RL | 1 |
| Balczo, E; Gobalakrishnapillai, V; Hall, BS; Hu, L; Seifert, K; Voak, AA; Wilkinson, SR | 1 |
| Altcheh, J; Bisio, M; Bournissen, FG; Burgos, JM; Fink, V; Freilij, H; Lattner, J; Moscatelli, G; Schijman, AG | 1 |
| Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA | 1 |
| Albajar-Viñas, P; Coura, JR; Dias, JC; Diniz, GA; Lana, Md; Machado-Coelho, GL; Machado-de-Assis, GF; Montoya, RA; Torres, RM | 1 |
| Altcheh, J; Dana, DD; García-Bournissen, F; Marsón, ME; Mastrantonio, G | 1 |
| Bern, C; Castellon, M; Gilman, RH; Lozano Beltran, DF; Solano Mercado, MA; Sullca, W; Tornheim, JA; Torrico, F | 1 |
| Ayala, AP; Boechat, N; Ellena, J; Honorato, SB; Mendes Filho, J; Mendonça, JS; Oliveira, AC | 1 |
| Bombardiere, ME; Leonardi, D; Salomon, CJ | 1 |
| Ferraz, LR; Figueirêdo, CB; Lima Leite, AC; Lyra, MA; Neves de Lima, ÁA; Peixoto, MS; Rolim Neto, PJ; Rolim, LA; Santos, FL; Soares-Sobrinho, JL | 1 |
| Aguilera-Venegas, B; Arán, VJ; Olea-Azar, C; Speisky, H | 1 |
| Alarcón de Noya, B; Araujo-Jorge, T; Gascon, J; Grijalva, MJ; Guhl, F; López, MC; Ramsey, JM; Ribeiro, I; Schijman, AG; Sosa-Estani, S; Torrico, F; Viotti, R | 1 |
| Bahia, MT; Caldas, IS; Daliry, A; de Carvalho, AC; de Figueiredo Diniz, L; Talvani, A; Torres, RM | 1 |
| Beaulieu, C; Black, WC; Isabel, E; Massé, F; Mellon, C; Methot, N; Nath-Chowdhury, M; Ndao, M; Nicoll-Griffith, DA; Vasquez-Camargo, F | 1 |
| Alves, CL; Cruz, AK; de Medeiros, MH; de Moura, MB; de Souza-Pinto, NC; Franco, GR; Furtado, C; Garcia, JB; Kunrath-Lima, M; Macedo, AM; Machado, CR; Mendes, IC; Motta, MC; Passos-Silva, DG; Pena, SD; Rajão, MA; Schamber-Reis, BL; Teixeira, SM; Vieira-da-Rocha, JP; Zuma, AA | 1 |
| Faral-Tello, P; Liang, M; Mahler, G; Robello, C; Wipf, P | 1 |
| de Araujo, AC; De Mattos, JC; García-Huertas, PA; Hamedt, AL; Ortiz, IC; Rodríguez-Gazquez, MA; Sáenz, J; Triana-Chávez, O | 1 |
| Fujikura, Y; Imai, K; Iwata, O; Kawana, A; Kurane, I; Maeda, T; Mikita, K; Misawa, K; Miura, S; Miyahira, Y; Nagumo, M; Ono, T; Sayama, Y | 1 |
| Branquinho, RT; de Lana, M; de Oliveira-Silva, JC; Mosqueira, VC; Saúde-Guimarães, DA; Simões-Silva, MR | 1 |
| Campos, MC; Kelly, JM; Leon, LL; Taylor, MC | 1 |
| Castillo, C; Droguett, D; Duaso, J; Galanti, N; Kemmerling, U; Liempi, A; López-Muñoz, R; Maya, JD; Rojo, G | 1 |
| Corrêa, AG; Nakamura, CV; Rodrigues, JH; Sangi, DP; Ueda-Nakamura, T | 1 |
| Fisa, R; Fumadó, V; Gállego, M; Gascón, J; Juncosa, T; Posada, E | 1 |
| Rendon, DA | 1 |
| Alvarez, G; Batthyany, CI; Cerecetto, H; Corre, S; Durán, R; Faral-Tello, P; González, M; Robello, C; Trochine, A | 1 |
| Albuquerque, EL; Bezerra, EM; Bezerra-Neto, JR; Caetano, EW; de Lima-Neto, P; dos Santos, RP; Freire, VN; Martins, AM; Sales, FA | 1 |
| Altcheh, J; García-Bournissen, F; Marson, ME; Mastrantonio, GE; Moroni, S; Moscatelli, G | 1 |
| Bustamante, JM; Tarleton, RL | 1 |
| Batista, MM; Boykin, DW; Da Silva, PB; Farahat, AA; Kumar, A; Soeiro, MN; Timm, BL | 1 |
| Alves, LD; Lima, AA; Lyra, MA; Nunes, LC; Rolim, LA; Rolim-Neto, PJ; Santos, FL; Soares, MF; Soares-Sobrinho, JL; Torres-Labandeira, JJ | 1 |
| Bakunov, SA; Bakunova, SM; Batista, MM; da Silva, CF; da Silva, FH; da Silva, PB; Jones, SK; Patrick, DA; Soeiro, Mde N; Tidwell, RR; Timm, BL | 1 |
| Blanco-Grau, A; Cabezos, J; Gómez i Prat, J; Molina, I; Pahissa, A; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L; Vidal, X | 1 |
| Albajar-Viñas, P; Dias, JC | 1 |
| Bahia, MT; Caldas, IS; Charman, SA; Chatelain, E; Diniz, Lde F; Gonçalves, KR; Koltun, M; Marques, LF; Mazzeti, AL; Mota, LW; Nascimento, AF; Saunders, J; Scandale, I; Shackleford, DM; Talvani, A; White, KL | 1 |
| Altcheh, J; Ballering, G; Bisio, M; García-Bournissen, F; Giglio, N; Koren, G; Marson, ME; Mastrantonio, G; Moroni, S; Moscatelli, G | 1 |
| Barrett, MP; Creek, DJ; Faral-Tello, P; Robello, C; Trochine, A | 1 |
| Moraes, CM; Pasqualotto, AC; Poloni, JA; Rotta, LN; Seelig, DC | 1 |
| Flash, CA; Goodman, JC; Patel, SM; Stager, CE; Woc-Colburn, L; Yasukawa, K | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Palmeiro-Roldán, R; Torrado-Durán, S; Torrado-Santiago, S | 1 |
| Galanti, N; Jimenez, V; Kemmerling, U; Maya, JD; Paredes, R; Sosa, MA | 1 |
| Bibolini, J; Cicora, F; Escurra, V; González, I; Petroni, J; Roberti, J | 1 |
| Alvarenga Americano do Brasil, PE; da Costa Chambela, M; da Silva, JA; de Sousa, AS; Hasslocher-Moreno, AM; Magalhães Saraiva, R; Mediano, MF; Rodrigues da Costa, A; Sperandio da Silva, GM; Xavier, SS | 1 |
| Alonso, C; Carrilero, B; Fernández-Villegas, A; López, MC; Marañón, C; Moralo, S; Murcia, L; Segovia, M; Téllez, C; Thomas, MC | 1 |
| Altcheh, J; Ballering, G; Bisio, M; Cornou, L; García-Bournissen, F; Marson, ME; Mastrantonio, G; Moroni, S; Moscatelli, G | 1 |
| Manne-Goehler, J; Ramsey, JM; Reich, MR; Salgado, MO; Wirtz, VJ | 1 |
| Carneiro, ZA; da Silva, RS; Milanezi, C; Santos, M; Sesti-Costa, R; Silva, GK; Silva, JS; Silva, MC | 1 |
| Cerutti, S; Marson, ME; Martínez, N; Mastrantonio, GE; Raba, J | 1 |
| Basombrio, MA; Davies, C; Dey, N; Garg, NJ; Negrette, OS; Parada, LA | 1 |
| Aldasoro, E; Gascon, J; Munoz, J; Oliveira, I; Pinazo, MJ; Posada, E; Requena-Méndez, A; Serret, N | 1 |
| Davanço, MG; de Campos, ML; Peccinini, RG | 1 |
| Aznar, C; Bisio, M; Blanchet, D; Brenière, SF; Demar-Pierre, M; Djossou, F; Mayence, C; Schijman, AG; Simon, S; Véron, V | 1 |
| Barreto, HM; Bua, J; de Carvalho Sousa, F; Duarte, AP; Liarte, DB; Murta, SM; Rádis-Baptista, G; Rêgo, JV; Romanha, AJ | 1 |
| Angheben, A; Anselmi, M; Bisoffi, Z; Buonfrate, D; Chiampan, A; Gobbi, F; Mainardi, P; Marocco, S; Postiglione, C; Repetto, E; Tais, S | 1 |
| de Araujo, FF; Debrabant, A; Gupta, C; Marino, AP; Nagarkatti, R | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Palmeiro-Roldán, R; Torrado, S; Torrado-Santiago, S | 1 |
| Eells, SJ; Hernandez, S; Meymandi, SK; Miller, DA; Miller, LG; Rodriguez De Armas, L; Traina, MM | 1 |
| Alonso-Padilla, J; Bardera, AI; Cantizani, J; Cotillo, I; Martín, JJ; Peña, I; Presa, JL; Rodriguez, A | 1 |
| Batista, MA; Béla, SR; Campi-Azevedo, AC; Correa-Oliveira, R; Eloi-Santos, SM; Gomes, JA; Martins-Filho, OA; Peruhype-Magalhães, V; Sathler-Avelar, R; Schachnik, NC; Silveira-Lemos, D; Silvestre, KF; Teixeira-Carvalho, A; Vitelli-Avelar, DM | 1 |
| Ferreira, RC; Franco, J; Ienne, S; Zingales, B | 1 |
| Morilla, MJ; Romero, EL | 1 |
| Califano, AN; Echevarria, RN; Padró, JM; Pellegrino Vidal, RB; Reta, MR | 1 |
| Chaplin, JH; Keenan, M | 1 |
| Araújo, MS; Carneiro, CM; Lana, Md; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Oliveira, MT; Oliveira-Silva, JC; Paiva, NC | 1 |
| Imai, K; Kawana, A; Kurane, I; Maeda, T; Mikita, K; Miura, S; Miyahira, Y; Osa, M; Sayama, Y | 1 |
| García, MC; Jimenez-Kairuz, AF; Manzo, RH | 1 |
| Aldasoro, E; Gascón, J; Guerrero, L; Mejía, T; Posada, E; Serret, N; Soy, D; Urbina, JA | 1 |
| Fortes Francisco, A; Kelly, JM; Lewis, MD; Taylor, MC; Wilkinson, SR | 1 |
| Baeza, I; Meza-Toledo, S; Nogueda-Torres, B; Serna, M; Wong, C; Wong-Baeza, C | 1 |
| Bastos, DS; Carvalho, TV; Cupertino, MC; Neves, MM; Novaes, RD; Oliveira, JM; Oliveira, LL; Santos, EC; Talvani, A | 1 |
| Araújo, SM; Barbosa, Md; Gomes, ML; Gruendling, AP; Kaneshima, EN; Massago, M; Monteiro, WM; Teston, AP; Toledo, MJ | 1 |
| Almeida, IC; Bustamante, J; Gascon, J; Lopez, MC; Pinazo, MJ; Thomas, MC | 1 |
| Aguiar, PH; Araujo, RG; Brandão, A; Franco, J; Ienne, S; Machado, CR; Moreno, M; Nunes, SL; Silva, MN; Zingales, B | 1 |
| Campos-Estrada, C; Ferreira, J; González-Herrera, F; Kemmerling, U; Lapier, M; Liempi, A; López-Muñoz, R; Maya, JD; Pesce, B | 1 |
| Manne-Goehler, J; Reich, MR; Wirtz, VJ | 1 |
| Altcheh, J; Ballering, G; Bisio, M; Freilij, H; García-Bournissen, F; Moroni, S; Moscatelli, G | 1 |
| Albareda, MC; Laucella, SA | 1 |
| Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC | 1 |
| Bocanegra, C; Molina, I; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L | 1 |
| Assíria Fontes Martins, T; Bahia, MT; Caldas, IS; Caldas, S; da Silva do Nascimento, ÁF; de Andrade, IM; de Figueiredo Diniz, L; Mazzeti, AL; Ribeiro, I | 1 |
| Bastos, DS; Cardoso, SA; Gonçalves, WG; Novaes, RD; Oliveira, JM; Oliveira, LL; Penitente, AR; Santos, EC; Talvani, A | 1 |
| Bahia, MT; Bastos, DS; Cupertino, MC; Fietto, JL; Klein, RC; Novaes, RD; Oliveira, LL; Santos, EC; Silva, EA; Talvani, A | 1 |
| Anibal, Fde F; Costa, FC; da Silva, MT; de Lima, GM; Portapilla, GB; Silva-Jardim, I; Thiemann, OH | 1 |
| Almirante, B; Molina, I; Salvador, F; Sánchez-Montalvá, A; Sao Avilés, A; Serre, N; Treviño, B | 1 |
| Morel, CM; Thota, S | 1 |
| Marín, C; Martín-Escolano, R; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Urbanová, K | 1 |
| Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V | 1 |
| Ferreira, MJ; Lamas, MC; Leonardi, D; Nunes, TG; Priotti, J; Salomon, CJ | 1 |
| Aparicio, G; Artaza, MÁ; Ferrer, B; García-Prat, M; Martínez-Gallo, M; Molina, I; Sala-Cunill, A; Salvador, F; Sánchez-Montalvá, A; Sao Avilés, A; Viñas, L | 1 |
| Alba Soto, CD; Curto, MLA; Lammel, EM; Miranda, CG; Schijman, AG; Solana, ME | 1 |
| Bhattacharyya, T; Burleigh, BA; Costales, JA; Garcia-Perez, J; Kotton, CN; Llewellyn, MS; Messenger, LA; Zurita-Leal, AC | 1 |
| Avezum, A; Bonilla, L; Bonilla, R; Britto, C; Connolly, SJ; Guhl, F; Lazdins, J; Marin-Neto, JA; Mattos, A; Meeks, B; Morillo, CA; Pogue, J; Quiroz, R; Rao-Melacini, P; Rassi, A; Rosas, F; Sosa-Estani, S; Velazquez, E; Villena, E; Yusuf, S | 1 |
| Cifuente, D; Lozano, E; Rivarola, HW; Sosa, MA; Spina, R; Strauss, M; Tonn, C | 1 |
| de Paula Costa, G; Horta, AL; Leite, AL; Natali, AJ; Neves, CA; Penitente, AR; Shrestha, D; Talvani, A | 1 |
| Avezum, Á; Cordeiro Mattos, AJ; Oliveira, GB | 1 |
| Batista, DG; Britto, C; da Silva, CF; de Araújo, JS; Ferreira, CG; Guedes-da-Silva, FH; Lepesheva, GI; Meuser, MB; Moreira, OC; Simões-Silva, MR; Soeiro, Mde N | 1 |
| Ciapponi, A; Comandé, D; Cuesta, CB; Hicks, E; Roberts, KN; Sguassero, Y; Sosa-Estani, S | 1 |
| Carneiro, ZA; Carvalho, I; Carvalho, MR; de Andrade, P; de Melo, EB; Galo, OA; Lopes, CD; Sesti-Costa, R; Silva, JS | 1 |
| Friedman, JM; Garg, NJ; Lora, JN; Machado, FS; Moraes, DN; Nagajyothi, J; Nunes, MC; Ribeiro, AL; Spray, DC; Tanowitz, HB; Weiss, OS | 1 |
| Angheben, A; Aprili, G; Bisoffi, Z; Boix, L; Buonfrate, D; Gandini, G; Gobbi, F; Pupella, S | 1 |
| Coelho, PL; de Oliveira Cardoso, MV; de Oliveira Filho, GB; de Simone, CA; Espíndola, JW; Ferreira, LF; Ferreira, RS; Lima Leite, AC; Magalhaes Moreira, DR; Meira, CS; Soares, MB | 1 |
| Ramos, C; Vela-Bahena, LE; Vergara, R; Vite, L | 1 |
| Abril, M; Albizu, CL; Álvarez, MG; Bertocchi, G; Cura, C; Fernández, M; Hernández, Y; Lococo, B; Ramírez, JC; Schijman, A; Sosa-Estani, S; Viotti, R | 1 |
| Díaz, ML; Escobar, P; González Rugeles, CI; Leal, S; López-Muñoz, R; Mantilla, JC; Molina-Berríos, A; Solari, A | 1 |
| Komajda, M; Ruschitzka, F | 1 |
| Abras, A; Aldasoro, E; de Almeida, IC; de Lazzari, E; Gallego, M; Gascon, J; Izquierdo, L; Marques, AF; Muñoz, J; Pinazo, MJ; Posada, Ede J; Reverter, JC; Tassies, D; Tebar, S | 1 |
| Bermudez, J; Davies, C; Palma, S; Real, JP; Simonazzi, A | 1 |
| Cunha-Filho, MS; Infante, CM; Pinho, LA; Sá-Barreto, LC | 1 |
| Alakurtti, S; Brun, R; Jaffe, CL; Kaiser, M; Kopelyanskiy, D; Moreira, VM; Nasereddin, A; Oksman-Caldentey, KM; Pirttimaa, M; Yli-Kauhaluoma, J | 1 |
| Bellón, T; Cabañas, R; Cachafeiro, L; González-Ramos, J; Herranz-Pinto, P; Noguera-Morel, L; Ramírez, E; Ruiz-Bravo, E; Tong, HY | 1 |
| Araújo, JS; Bakunov, SA; Bakunova, SM; Batista, DG; Britto, C; Da Silva, CF; Da Silva, PB; Demarque, KC; Fulco, TO; Guedes-da-Silva, FH; Meuser, MB; Moreira, OC; Oliveira, GM; Patrick, DA; Soeiro, MN; Tidwell, RR | 1 |
| Cannata, JJ; Garavaglia, PA; García, GA; Laverrière, M | 1 |
| Cevey, ÁC; Goren, NB; Mirkin, GA; Penas, FN | 1 |
| Alzate, AH; Campos, ML; Davanço, MG; Padilha, EC; Peccinini, RG; Rolim, LA; Rolim-Neto, PJ; Rosa, TA | 1 |
| Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A | 1 |
| Batista, C; Bottazzi, ME; Gascon, J; Gold, S; Hotez, PJ; Moriana, S; Navarro, M; Pecoul, B; Pereiro, A; Pinazo, MJ; Ribeiro, I; Stobbaerts, E; Torrico, F; Vilasanjuan, R | 1 |
| Costa, CA; Faccini, CC; Fragata, Cda S; Fragata-Filho, AA; França, FF; Lourenço, AM | 1 |
| Altcheh, J; Bournissen, FG; Fernández, ML; Marson, ME; Mastrantonio, G; Ramirez, JC; Riarte, AR; Schijman, AG | 1 |
| Caldas, IS; Gonçalves, RV; Novaes, RD; Rodrigues, JP; Santos, EC; Sartini, MV; Souza, RL | 1 |
| Bezerra, RC; Buccheri, R; Freitas, VL; Kassab, MJ; Khoury, Z; Shikanai-Yasuda, MA; Silva, SC; Vidal, JE | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM | 1 |
| Alonso, C; Carrilero, B; Egui, A; Fernandez-Villegas, A; Lasso, P; López, MC; Murcia, L; Segovia, M; Thomas, MC | 1 |
| Barbosa-Filho, JM; Guimarães, ET; Lanfredi-Rangel, A; Meira, CS; Moreira, DR; Soares, MB | 1 |
| Albareda, MC; Alvarez, MG; Bertocchi, GL; Castro Eiro, M; Cooley, G; Laucella, SA; Lococo, B; Perez-Mazliah, DE; Tarleton, RL; Viotti, R | 1 |
| Bierrenbach, AL; Cardoso, CS; Cunha-Neto, E; de Oliveira, LC; Ferreira, AM; Ferreira, JE; Haikal, DS; Oliveira, CD; Reingold, AL; Ribeiro, AL; Sabino, EC | 1 |
| Colantonio, LD; Prado, N; Segura, EL; Sosa-Estani, S | 1 |
| Britto, C; Cruz Moreira, O; da Silva, AA; de Souza Ruivo, LA; Lannes-Vieira, J; Resende Pereira, I; Vilar-Pereira, G | 1 |
| Bataille, AM; Catania, VA; Ciriaci, N; Francés, DE; Ghanem, CI; Manautou, JE; Perdomo, VG; Rigalli, JP; Ronco, MT; Ruiz, ML | 1 |
| Bahia, MT; Caldas, S; Gonçalves, KR; Lima, WG; Mazzeti, AL; Santos, FM; Torres, RM | 1 |
| Ayala, V; Bisio, M; Burgos, JM; Contreras, A; Coppede, M; Elean, JC; García-Bournissen, F; Gómez, KA; Grippo, V; Herrera, V; Juiz, NA; Lafón, SO; Levin, MJ; Levitus, G; Longhi, SA; López, C; Mujica, HD; Niborski, LL; Ramirez, JC; Schijman, AG | 1 |
| Arrúa, EC; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Scalise, ML | 2 |
| Briceno, L; Mosca, W | 1 |
| Arán, VJ; Batista, MM; DA Silva, CF; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Menna-Barreto, RF; Soeiro, Mde N | 1 |
| Branquinho, RT; de Mello, CG; Lana, Md; Milagre, MM; Mosqueira, VC; Oliveira, MT; Saúde-Guimarães, DA | 1 |
| Moreno-Viguri, E; Paucar, R; Pérez-Silanes, S | 1 |
| da Silva-Júnior, AA; Farias, KJ; Fernandes-Pedrosa, MF; Machado, PR; Sarmento, VH; Streck, L | 1 |
| Alarcón, A; Hahn, A; Jantausch, B; Montgomery, SP; Morgan, M; Scavo, L; Wong, EC | 1 |
| Alves-Silva, I; Cunha-Filho, MS; Gelfuso, GM; Lima, EM; Marreto, RN; Sá-Barreto, LC | 1 |
| Carrilero, B; Ferrer, F; Franco, F; Murcia, L; Roig, M; Segovia, M | 1 |
| Brunoro, GV; Caminha, MA; de Moura, KC; Faça, VM; Ferreira, AT; Menna-Barreto, RF; Perales, J; Trugilho, M; Valente, RH | 1 |
| Baba, EH; Dos Santos, PF; Moreira, DS; Murta, SMF; Romanha, AJ; Ruiz, JC; Volpe, CMO | 1 |
| Gutiérrez, C; López-Vélez, R; Monge-Maillo, B; Norman, FF; Pérez-Molina, JA; Vallejo, A | 1 |
| Antunes, AF; Barbosa, Md; Ferreira, JM; Guerra, JA; Maduro, SG; Pereira, BV | 1 |
| Cao, X; Chen, Y; Liu, BF; Liu, X; Qiu, Y; Xu, X; Yu, M; Zhang, G; Zhang, Y | 1 |
| Campos-Estrada, C; Castro, L; Cortes, L; Díaz, MV; Kemmerling, U; Lapier, M; López-Muñoz, R; Maya, JD; Miranda, MR; Morello, A; Pereira, CA; Reigada, C; Seguel, V | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Catania, VA; Luquita, MG; Pellegrino, JM; Perdomo, VG; Rigalli, JP; Ruiz, ML | 1 |
| Li, Q; Lin, Q; Yun, Z | 1 |
| Alvarellos, E; Alvarellos, T; Caeiro, JP; Cordeiro, E; Kohout, I; Rodriguez Schulz, DG; Sánchez, AG | 1 |
| Cardoso, CS; de Oliveira, LC; Ferreira, AM; Haikal, DS; Oliveira, CD; Ribeiro, AL; Sabino, EC | 1 |
| Carnovale, CE; Catania, VA; de Luján Alvarez, M; Francés, DE; Lambertucci, F; Martín-Sanz, P; Motiño, O; Quiroga, AD; Rigalli, JP; Ronco, MT; Villar, S | 1 |
| Andrades, ED; Andrades-Grassi, FA; Andrades-Grassi, JE; Cabrera, H; García, LC; Grassi, HC; Lobo-Sulbarán, ML; Velásquez, A | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Galvão, LMDC; Guedes, PMDM; Lima, WG; Nascimento, ÁFDSD | 1 |
| Castillo, C; Cramer, A; González-Herrera, F; Kemmerling, U; Liempi, A; Machado, FS; Maya, JD; Pimentel, P | 1 |
| Botero, A; Keatley, S; Peacock, C; Thompson, RC | 1 |
| Adeyemi, OS; Eseola, AO; Fonseca-Berzal, C; Gómez-Barrio, A; Molina, MT | 1 |
| Amarante, GW; Ávila, EP; de Azeredo, CM; Pinheiro, DL; Soares, MJ | 1 |
| Alarcón de Noya, B; Castro, J; Colmenares, C; Díaz-Bello, Z; Gutiérrez, H; Naranjo, L; Noya, O; Noya-Alarcón, O; Ossenkopp, J; Quinci, G; Ruiz-Guevara, R; Suárez, JA; Torres, J | 1 |
| Alonso-Pacheco, ML; González-Ramos, J; Herranz-Pinto, P; Mora-Rillo, M | 1 |
| Cardoso, JM; Carneiro, CM; Correa-Oliveira, R; Fonseca, KD; Mathias, FA; Molina, I; Moreira da Silva, R; Perin, L; Reis, LE; Vieira, PM | 1 |
| Balfour, MN; Franco, CH; Freitas-Junior, LH; Moraes, CB; Stefani, HA | 1 |
| Carrilero, B; Murcia, L; Roig, M; Segovia, M; Simón, M | 1 |
| Marin, JA; Rassi, A | 1 |
| Apt, W; Beloscar, J; Bonilla, LR; Colombo, H; Cuneo, C; Del Carmen Bangher, M; Echeverria, LE; Gao, P; Gascon, J; Mallagray, M; McCarthy, M; Meeks, B; Milesi, R; Molina, I; Morillo, CA; Perez-Molina, JA; Sosa-Estani, S; Waskin, H; Wei, B; Wyss, F; Yusuf, S | 1 |
| Bahia, MT; Bloomer, WD; Gonçalves, KR; Mazzeti, AL; Mendes, PF; Papadopoulou, MV; Rosenzweig, HS | 1 |
| García-Huertas, P; González, L; Mejía-Jaramillo, AM; Triana-Chávez, O | 1 |
| Almeida, SR; Atala, MM; Busser, FD; Carneiro, N; Carvalho, NB; de Freitas, VLT; de Oliveira, CMR; Ferrufino, RQ; Furucho, CR; Hage, M; Leite, RM; Luna, E; Martinelli, L; Sátolo, CG; Shikanai Yasuda, MA; Silva, RA; Viñas, PA; Wanderley, DM | 1 |
| Muñoz Casas Del Valle, P | 1 |
| de La Roca Soares, MF; de Medeiros Vieira, ACQ; Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Soares Sobrinho, JL | 1 |
| Cornélio, AM; da Silva-Júnior, AA; de Araújo-Júnior, RF; de Caland, LB; de S L Oliveira, ALC; Dos Santos-Silva, AM; Fernandes-Pedrosa, MF | 1 |
| Abi-Saab Arrieche, M; Aguilar, NG; Alves, RV; Chaves, GC; Mechali, D; Reis, PO; Ribeiro, I; Rode, J; Stobbaerts, E | 1 |
| Lazarin-Bidóia, D; Nakamura, CV; Peron, F; Rodrigues-Filho, E; Silva, SO; Ud Din, Z; Ueda-Nakamura, T | 1 |
| Brasil, PEAAD; Brum-Soares, LM; Cubides, JC; Fux, CP; Hasslocher-Moreno, AM; Holanda, MT; Mediano, MFF; Mejía, RA; Sangenis, LHC; Saraiva, RM; Silvestre de Sousa, A; Sperandio da Silva, GM | 1 |
| Leite, ALJ; Lopes, LR; Paula Costa, G; Reis Mota, LWD; Talvani, A; Vieira, PMA | 1 |
| Álvarez, MG; Bertocchi, G; Lococo, B; Vigliano, C; Viotti, R | 1 |
| Bahia, MT; Batista, DGJ; Batista, MM; Cardoso-Santos, C; D'Almeida-Melo, I; Da Silva, CF; Da Silva, PB; De Araújo, JS; Demarque, KC; Oliveira, GM; Peres, RB; Simões-Silva, MR; Soeiro, MNC | 1 |
| García, GA; García-Huertas, P; González, L; Mejía-Jaramillo, AM; Murta, SMF; Triana-Chávez, O | 1 |
| Alpern, JD; Lopez-Velez, R; Stauffer, WM | 1 |
| Agüero, F; Alvarez, VE; Cazzulo, JJ; Karpiak, J; Landaburu, LU; Madauss, KP; Salas-Sarduy, E | 1 |
| Zingales, B | 1 |
| Alonso, V; Leonardi, D; Real, D; Rocha, SC; Salomon, CJ; Santos Souza, HF; Serra, E; Silber, AM | 1 |
| Agreda-Rudenko, D; Cucunubá, ZM; Duque, S; Flórez, C; Herazo, R; Nicholls, RS; Olivera, MJ; Valencia-Hernández, CA | 1 |
| Acarregui, A; Elizondo, E; Esquisabel, A; Herráez, R; Oliver, L; Pedraz, JL; Veciana, J; Ventosa, N; Viñas, M; Vinuesa, T | 1 |
| Carneiro, CM; Corrêa-Oliveira, R; Fonseca Murta, SM; Molina, I; Sales Junior, PA; Salvador, F; Sánchez-Montalvá, A | 1 |
| Cevey, ÁC; Donato, M; Gelpi, RJ; Goren, NB; Mirkin, GA; Penas, FN; Rada, MJ | 1 |
| Leone, JL | 1 |
| Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC | 1 |
| Melton, L | 1 |
| Alonso-Vega, C; Alves, F; Curto, MA; de la Barra, A; Flevaud, L; García, L; Gascón, J; Irazu, L; Molina, I; Ortiz, L; Parrado, R; Ramírez, JC; Ribeiro, I; Rodríguez, M; Schijman, AG; Sulleiro, E; Torrico, F; Villarroel, S | 1 |
| Morrow, T | 1 |
| Chakradhar, S | 1 |
| Gonçalves, RV; Novaes, RD | 2 |
| Kian, D; Massago, M; Toledo, MJO; Zanusso Junior, G | 1 |
| Cubides, JC; Hasslocher-Moreno, AM; Holanda, MT; Mediano, MFF; Sangenis, LHC; Saraiva, RM; Sousa, AS; Sperandio da Silva, GM | 1 |
| Aldasoro, E; Calvo-Cano, A; Casellas, A; Gascon, J; Pinazo, MJ; Posada, E; Requena-Méndez, A; Sanz, S; Serret, N; Soy, D | 1 |
| Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F | 1 |
| Aguilera, E; Alvarez, G; Bilbao, NV; Cerecetto, H; González, M; Serna, E; Torres, S; Varela, J; Yaluff, G | 1 |
| Busch, MP; Caillaudeau, J; Cardoso, CS; de Oliveira, LC; Ferreira, AM; Granjon, E; Gueyffier, L; Lee, TH; Liehl, P; Oliveira, CDL; Pottel, H; Ribeiro, ALP; Sabino, EC; Zrein, M | 1 |
| Altcheh, J; Bisio, M; García-Bournissen, F; Gulin, JEN; Rocco, DM; Solana, ME | 1 |
| Alves, AÉG; Amariz, IAE; Costa, SPM; Ferraz, LRM; Ferreira, AS; Lima, ÁAN; Nascimento, DDSDS; Rolim Neto, PJ; Rolim, LA | 1 |
| Antinori, S; Bestetti, G; Bianco, R; Cogliati, C; Corbellino, M; De Maio, G; Egidi, AM; Galimberti, L; Galli, M; Garelli, S; Gismondo, MR; Grande, R; Lai, A; Mileto, D; Oreni, L; Petullà, M; Repetto, EC; Ricaboni, D; Ridolfo, AL; Torzillo, D; Traversi, L; Villa, AM | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I | 1 |
| Chopra, S; Dasgupta, A; Thakare, R | 1 |
| Andrade-Lima, L; Borsoi, J; da Silva Lara, L; Henriques-Pons, A; Lopes Alberto Duque, T; Magalhães Calvet, C; Souza Pereira, MC; Veiga Pereira, L | 1 |
| Calbacho Robles, M; Crespillo-Andújar, C; Norman, FF; Pérez-Molina, JA | 1 |
| Arán-Redó, VJ; Barigye, SJ; Escario, JA; García-Jacas, CR; Gómez-Barrio, A; Ibáñez-Escribano, A; Machado-Tugores, Y; Marrero-Ponce, Y; Meneses-Marcel, A; Nogal-Ruiz, JJ; Terán, E | 1 |
| Cruz-Granados, S; Moreno-Escobosa, C | 1 |
| Albuquerque, EL; Barroso Neto, IL; Bezerra, EM; de Menezes, RRPPB; Dos Santos, RP; Freire, VN; Lima, DB; Magalhães, EP; Martins, AM; Mello, CP; Oliveira, MF; Sales, FAM; Tessarolo, LD | 1 |
| Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Schver, GCRM; Soares Sobrinho, JL; Soares, MFR; Vieira, ACQM | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Martinelli, M; Ponce, NE; Sanmarco, LM | 1 |
| Báez, AL; Bazán, PC; Bustamante, JM; Lo Presti, MS; Nakamura, CV; Paglini-Oliva, P; Rivarola, HW; Rodrigues, JHS; Strauss, M | 1 |
| Bastos, MM; Batista, DDGJ; Bianco, MDCAD; Boechat, N; da Gama, ANS; da Silva, CF; da Silva, PB; de Oliveira, AP; Fontes, FV; Hoelz, LVB; Leite, DI; Peres, RB; Soeiro, MNC; Villar, JDF | 1 |
| García, MC; Jimenez-Kairuz, A; Manzo, RH | 1 |
| Cuéllar, A; Egui, A; González, JM; López, MC; Pérez-Antón, E; Puerta, CJ; Segovia, M; Thomas, MC | 1 |
| Chamorro-Tojeiro, S; Crespillo-Andújar, C; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA | 1 |
| Aiub, CAF; Araujo-Lima, CF; Batista, MM; Felzenszwalb, I; Peres, RB; Silva, PB; Soeiro, MNC | 1 |
| Camargo, RS; Carneiro, ZA; de Albuquerque, S; do Vale, GT; Portapilla, GB; Providello, MV; Tirapelli, CR | 1 |
| Burleigh, BA; Dumoulin, PC | 1 |
| Brancaglion, GA; Caldas, IS; Cardoso Machado, JV; Carvalho, DT; Dos Santos, EG; Fernandes Júnior, AÁ; Silveira, AT; Toyota, AE; Vilas Boas, DF | 1 |
| Bermúdez, JM; Cid, AG; Davies, C; Gonzo, E; Parada, L; Simonazzi, A | 1 |
| Crespillo-Andújar, C; López-Polín, A; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Venanzi-Rullo, E | 1 |
| García, MC; Guzman, ML; Himelfarb, MA; Jimenez-Kairuz, A; Litterio, NJ; Olivera, ME | 1 |
| Allen, CK; Brown, MN; Dougherty, CP; Herwaldt, BL; Jolly, JP; Yu, P; Yu, Y | 1 |
| Duarte, AP; Moreira, DS; Murta, SMF; Pais, FSM; Romanha, AJ; Schenkman, S; Silva-Pereira, RAD | 1 |
| Forsyth, CJ; Garcia Bournissen, F; Kratz, JM; Sosa-Estani, S | 1 |
| Hussar, DA | 1 |
| Batista, R; Loebe, M; Macias, AE; Magarakis, M; Reis, V; Salerno, TA; Tompkins, BA | 1 |
| Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A | 1 |
| Batlle, A; Demaria, A; Frank, FM; Lombardo, ME; Puente, V | 1 |
| Albareda, MC; Alvarez, MG; Bua, J; Castro Eiro, MD; Cooley, G; De Rissio, AM; Fernandez, M; Fichera, LE; Laucella, SA; Lococo, B; Natale, MA; Nuñez, M; Scollo, K; Serjan, A; Shen, H; Tarleton, RL; Viotti, R | 1 |
| Altcheh, J; Alves, F; Blum, B; Damasceno Sousa, G; Galindo Bedor, DC; Garcia-Bournissen, F; Pereira de Santana, D; Ribeiro, I; Tavares Cavalcanti Bedor, NC; Viturino da Silva, JW | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Menezes, APJ; Nascimento, ÁFDSD; Novaes, RD | 1 |
| Benatar, AF; Búa, J; Esteva, MI; Fichera, LE; López Alarcón, M; Prado, NG; Rial, MS; Riarte, AR; Scalise, ML | 1 |
| Chin, CM; da Rosa, JA; de Andrade, CR; Dos Santos, JL; Scarim, CB | 1 |
| Bezerra, FS; Costa, GP; Figueiredo, VP; Horta, AL; Leite, ALJ; Menezes, APJ; Pedrosa, TCF; Ramos, CO; Talvani, A; Vieira, PMA | 1 |
| Egui, A; Lasso, P; López, MC; Pérez-Antón, E; Thomas, MC | 1 |
| Bierrenbach, AL; Busch, MP; Cardoso, CS; Colosimo, EA; Ferreira, AM; Ferreira, JE; Lee, TH; Oliveira, CDL; Oliveira, LC; Reingold, AL; Ribeiro, ALP; Sabino, EC; Silva, JLP | 1 |
| Bastos, TM; Efstathiou, A; Gaboriaud-Kolar, N; Meira, CS; Rocha, VPC; Skaltsounis, AL; Smirlis, D; Soares, MBP; Vougogiannopoulou, K | 1 |
| Avalos Esquivel, JL; Crespo, M; García López, E; Grau, S; Horcajada, JP; López Montesinos, I; Mir, M; Molina-Morant, D; Monge, I; Montero, M; Mounteis Oliva, E; Pascual, J; Sorlí, L; Sulleiro, E; Veliz Espinosa, G | 1 |
| Carneiro, ZA; Chaves, JDS; de Albuquerque, S; de Almeida, MV; de Oliveira, LP; de Oliveira, RJ; Ellena, J; Guerra, W; Guilardi, S; Lopes, CD; Lopes, NP; Moreira, MB; Netto, AVG; Paixão, DA; Pivatto, M; Sousa, LM | 1 |
| da Silva-Júnior, AA; de Menezes, RPRPB; Fernandes-Pedrosa, MF; Martins, AMC; Sarmento, VHV; Streck, L | 1 |
| Borchardt, RA; Tzizik, DM | 1 |
| Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F | 1 |
| Alves-Silva, LS; Amarante, E; Barral-Netto, M; Barreto, LO; Camara, EJN; Carvalho, JS; Chiacchio, G; Cunha, M; Gatto, R; Guimarães, BAC; Lessa, RA; Mendonca, VRR; Souza, LCL | 1 |
| Clares, MP; Delgado-Pinar, E; García-España, E; Marín, C; Martín-Escolano, J; Martín-Escolano, R; Martin-Montes, Á; Medina-Carmona, E; Molina-Carreño, D; Pitarch-Jarque, J; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Batista, DDGJ; Batista, MM; Britto, C; Da Silva, CF; Guedes-da-Silva, FH; Lepesheva, GI; Moreira, OC; Pavão, BP; Rachakonda, G; Soeiro, MNC; Souza, LRQ; Villalta, F | 1 |
| Akutsu, Y; Doi, M; Furukawa, K; Takagi, Y | 1 |
| Buekens, P; Dumonteil, E; Herrera, C | 1 |
| Abril, M; Alonso-Padilla, J; Barreira, F; Bottazzi, ME; Cortés-Serra, N; Gascón, J; Hotez, PJ; Pinazo, MJ; Sosa-Estani, S | 1 |
| Echeverria, LE; Morillo, CA | 1 |
| Dolgalev, I; Dominguez-Bello, MG; Frattaroli, P; Heguy, A; Hevia, A; Hoashi, M; Iraola, G; Maldonado, DP; Mojica, M; Montacutti, V; Robello, C | 1 |
| Bahia, MT; Bastos, MM; Batista, MM; Boechat, N; Da Silva, PB; De Araújo, JS; De Azevedo, LD; Peres, RB; Simões-Silva, MR; Soeiro, MNC | 1 |
| Alonso-Padilla, J; Cortes-Serra, N; Gascon, J; Pinazo, MJ; Reverter, JC; Tassies, D | 1 |
| Albareda, MC; Alvarez, MG; Castro Eiro, MD; Cesar, GL; Laucella, SA; Natale, MA | 1 |
| Couceiro, KDN; Doria, SS; Ferreira, JMBB; Guerra, JAO; Guerra, MDGVB; Lira, EDF; Ortiz, JV; Pereira, BVM; Silva, MRHDSE; Silva, PRLD | 1 |
| Herrero-Martínez, JM; Lizasoain Hernández, M; Losada Galván, I; Madrid Pascual, O; Pérez-Ayala, A | 1 |
| Cebrián, R; Maqueda, M; Marín, C; Martín-Escolano, J; Martín-Escolano, R; Rosales, MJ; Sánchez-Moreno, M | 1 |
| Assíria, T; Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Ribeiro, I; WonDollinger, RS | 1 |
| Custodio Leite, TO | 1 |
| Bissember, AC; Dasari, R; Just, J; Kornienko, A; Rogelj, S; Smith, JA; Turner, DN | 1 |
| Brandão Peres, R; Britto, C; Cristina Demarque, K; da Cruz Moreira, O; de Melo Oliveira, G; de Nazaré Correia Soeiro, M; Diego de Souza Campos, J; Finamore Araújo, P; França da Silva, C; Lima da Costa, K; Machado Cascabulho, C; Meuser Batista, M; Nefertiti da Gama, A; Rocha Simões-Silva, M | 1 |
| Assy, JGPL; Berreta, OCP; Esper, HR; França, FOS; Freitas, VLT; Lopes, MH; Shimoda, EY | 1 |
| Cornélio, AM; da Silva-Júnior, AA; de Araújo-Júnior, RF; de Caland, LB; do Nascimento, EG; Dos Santos-Silva, AM; Fernandes-Pedrosa, MF; Oliveira, ALCSL | 1 |
| Asti, L; Bartsch, SM; Bottazzi, ME; Falcón-Lezama, JA; Hotez, PJ; Lee, BY; Meymandi, S; Randall, S; Strych, U | 1 |
| Romanha, AJ; Romero, I; Steindel, M; Téllez, J | 1 |
| Gonçalves, RV; Maldonado, IRSC; Mendonça, AAS; Natali, AJ; Novaes, RD; Souza-Silva, TG; Talvani, A | 1 |
| Encalada, R; González-Chávez, Z; Manning-Cela, R; Márquez-Dueñas, C; Mejia-Tlachi, M; Michels, PAM; Moreno-Sánchez, R; Rodríguez-Enríquez, S; Saavedra, E; Vázquez, C | 1 |
| Alba Soto, CD; Cevey, ÁC; Goren, NB; Mirkin, GA; Penas, FN | 1 |
| Avery, VM; Bernhardt, PV; Boyle, GM; Burns, JM; Chalmers, BA; De Voss, JJ; Fahrenhorst-Jones, T; Farfan Soto, C; Houston, SD; Savage, GP; Smith, MT; Stok, JE; Sykes, ML; Tsanaktsidis, J; Williams, CM; Xing, H | 1 |
| Burki, T | 1 |
| Carneiro, CM; Cunha, ELA; Cunha, LM; de Lana, M; de Oliveira, MT; Fonseca, KDS; Torchelsen, FKVDS; Vieira, PMA | 1 |
| Boechat, N; Conde, TR; de Carvalho, AS; de Castro, SL; Lemos, RC; Pitombeira, MCS; Quaresma, BMC; Salomão, K; Von Trompowsky, ACM; Zamith, HPDS | 1 |
| Arrúa, EC; Bedogni, GR; Okulik, NB; Salomon, CJ; Seremeta, KP | 1 |
| de la Rosa-Arana, JL; González-Garduño, R; Lara-Bueno, A; López-Arellano, ME; Maldonado-Simán, EJ; Santiago-Figueroa, I | 1 |
| Castellanos Domínguez, YZ; Cucunubá, ZM; Hernández, Y; Herrera, VM; Pérez Carreño, JG; Prado, NG; Váquiro Herrera, E; Vásquez, SM; Villar, JC | 1 |
| Batista, AHM; Canuto, JA; de Menezes, RRPPB; Grangeiro, TB; Lima, DB; Martins, AMC; Nogueira, NAP; Nogueira, PCDN; Silveira, ER | 1 |
| Inga, LAC; Olivera, MJ | 1 |
| Kratz, JM | 1 |
| Carneiro, ACA; Carvalho, ACC; Costa, GP; Ferreira, CS; Gonçalves, RV; Leite, ALJ; Menezes, APJ; Nogueira, KOPC; Ramos, IPR; Sarandy, MM; Silva, BM; Talvani, A | 1 |
| Bronzon da Costa, CM; Bulhões Portapilla, G; de Albuquerque, S; Ferreira Anchieta, N; Goulart, A; Leite Braga, GÚ; Pereira, LM; Sampaio Oliveira, PA; Voltarelli Providello, M; Wainwright, M | 1 |
| Gonçalves, RV; Maldonado, IRSC; Natali, AJ; Novaes, RD; Santos, EC; Santos, EG; Souza-Silva, TG; Talvani, A | 1 |
| Muñoz-Calderon, A; Schijman, AG; Sulleiro, E | 1 |
| Branquinho, RT; de Assis, G; de Lana, M; de Oliveira, MT; Gonçalves, MF; Milagre, MM; Reis, L; Saúde-Guimarães, DA | 1 |
| Caldas, IS; Novaes, RD; Santos, EG | 1 |
| Altcheh, J; Ballering, G; Bisio, M; Corral, R; Freilij, H; García Bournissen, F; González, N; Moroni, S; Moscatelli, G; Schijman, A | 1 |
| Bartholomeu, DC; Costa-Martins, AG; Petravicius, PO; Reis-Cunha, JL; Silva, MN; Teixeira, MMG; Zingales, B | 1 |
| Espínola, EE; Espinoza, E; Guzman, A; Hirayama, K; Kamel, MG; Kikuchi, M; Mizukami, S; Mochizuki, K; Na-Bangchang, K; Nishizawa, JE; Quiroga, B; Revollo, J; Rios Morgan, S; Roca, Y; Russomando, G; Sanchez, Z; Tien Huy, N; Vargas Ortiz, R; Vásquez Velásquez, C; Zambrana Ortega, A | 1 |
| Aviles, AS; Carneiro, CM; Cunha, LM; da Silva Fonseca, K; de Abreu Vieira, PM; Molina, I; Perin, L | 1 |
| Alba Soto, CD; Areco, Y; Bellera, CL; Buchholz, B; Carrillo, C; Gelpi, RJ; Kelly, J; Miranda, C; Quarroz Braghini, J; Sbaraglini, ML; Talevi, A | 1 |
| Egui, A; López, MC; Pérez-Antón, E; Segovia, M; Simón, M; Thomas, MC | 1 |
| Caldas, IS; Chagas-Paula, DA; Diniz, LF; Fernandes, VHC; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, CM; Rodrigues, MR; Veloso, MP; Vilas-Boas, DF | 1 |
| Arsuaga, M; Crespillo-Andújar, C; Díaz-Menéndez, M; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Trigo, E | 1 |
| Chappuis, F; Jackson, Y; Wyssa, B | 1 |
| Amaral, BR; Argenta, DF; Caon, T; Kroth, R | 1 |
| Egui, A; Gómez, I; López, MC; Segovia, M; Simón, M; Thomas, MC | 1 |
| Campos-Estrada, C; Carillo, I; Castillo, C; González-Herrera, F; Greif, G; Guzmán-Rivera, D; Kemmerling, U; Liempi, A; Maya, JD; Robello, C | 1 |
| Agapiou, E; Mavridis, IN; Meliou, M; Pyrgelis, ES | 1 |
| Carneiro, CM; Carvalho, LM; Correa-Oliveira, R; de Carvalho, TV; Fonseca, KDS; Madeira, JV; Medeiros, LDF; Molina, I; Perin, L; Vieira, PMA | 1 |
| Bahia, MT; Gonçalves, KR; Mazzeti, AL; Mosqueira, VCF; Oliveira, LT; Schaun, GC | 1 |
| Arruda, HMBDS; Gontijo, MKCL; Noronha, EF; Toledo, MI | 1 |
| Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU | 1 |
| Goterris, L; Molina, I; Moure, Z; Oliveira, I; Pou, D; Pumarola, T; Salvador, F; Sánchez-Montalvá, A; Sao-Aviles, A; Serre-Delcor, N; Silgado, A; Sulleiro, E; Tavares de Oliveira, M; Treviño, B | 1 |
| Cascabulho, CM; Castro, SL; Demarque, KC; Duque, TLA; Guimarães, ACR; Manso, PPA; Menna-Barreto, RF; Meuser-Batista, M; Moura, KCG; Oliveira, GM; Pelajo-Machado, M; Pinto, MDC | 1 |
| Carrilero, B; Gil-Gallardo, LJ; Iborra, MA; Romay-Barja, M; Segovia, M; Simón, M; Vázquez, C | 1 |
| Bialek, SR; Montgomery, SP; Perez-Zetune, V; Stillwaggon, E | 1 |
| Alonso-Padilla, J; Cortes-Serra, N; Fernandez-Becerra, C; Gascon, J; Losada-Galvan, I; Pinazo, MJ | 1 |
| Carrilero, B; Franco, F; García-Vázquez, E; Gil-Gallardo, LJ; Iborra, MA; Segovia, M; Simón, M; Vázquez, C | 2 |
| Barrera, MG; Lamas, MC; Leonardi, D; Salomón, CJ; Tejada, G | 1 |
| Arrúa, EC; Bua, J; Esteva, MI; Fichera, LE; Laucella, SA; Natale, MA; Prado, NG; Rial, MS; Salomon, CJ | 1 |
| Bangher, M; Bosch-Nicolau, P; Correa-Oliveira, R; de Paula, AMB; Eloi, S; Fernández, ML; Molina, I; Molina-Morant, D; Ribeiro, ALP; Salvador, F; Sanchez-Montalva, A; Sosa-Estani, S; Sulleiro, E; Villar, JC | 1 |
| Balthazar Nardotto, GH; Correa-Oliveira, R; da Silva Fonseca, K; Fernanda Rodrigues Bastos Mendes, T; Martins Carneiro, C; Melo de Abreu Vieira, P; Molina, I; Oliveira Paiva, B; Perin, L; Pinto, L | 1 |
| Bezerra de Menezes, RRPP; Freire, KA; Lima, DB; Martins, AMC; Monteiro, ML; Oliveira, VX; Torres, MT | 1 |
| de Almeida Araújo, EJ; Lovo-Martins, MI; Lucchetti, BFC; Malvezi, AD; Martins-Pinge, MC; Pereira, RS; Pinge-Filho, P; Santos, JP; Tavares, ER; Verri, WA; Yamada-Ogatta, SF; Yamauchi, LM | 1 |
| Bermúdez, JM; Cid, AG; Davies, C; Micheloud, JF; Negrette, OS; Parada, LA; Ragone, PG; Simonazzi, A | 1 |
| Caldas, IS; Diniz, LF; Gonçalves, RV; Gonçalves-Santos, E; González-Lozano, KJ; Mendonça, AAS; Novaes, RD; Souza-Silva, TG | 2 |
| Arsuaga, M; Balas, A; Bellón, T; Cabañas, R; de Abajo, F; Fiandor, A; Herranz, P; Lerma, V; LuisVicario, J; Ramírez, E; Sanz, B; Trigo, E | 1 |
| Alcântara, L; Antonini, L; Botelho Pereira Soares, M; Haddad Franco, C; Holanda Freitas-Junior, L; Mai, A; Matutino Bastos, T; Mautone, N; Moraes, CB; Ragno, R; Rotili, D; Sabatino, M; Schenkman, S; Silvio Moretti, N | 1 |
| Arán, VJ; Batista, DDGJ; Batista, MM; Cumella, J; da Silva, CF; de Oliveira, GM; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Peres, RB; Silva da Gama Nefertiti, A; Soeiro, MNC | 1 |
| Maguire, JH; Manne-Goehler, J; Reich, MR; Yoshioka, K | 1 |
| Abril, M; Álvarez, MG; Bertocchi, G; Castro Eiro, M; Cura, C; Fernández, M; Hernández, Y; Laucella, S; Lococo, B; Lopez-Albizu, C; Natale, MA; Ramírez, JC; Schijman, A; Sosa-Estani, S; Tarleton, RL; Viotti, R | 1 |
| Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC | 1 |
| Braissant, O; Fesser, AF; Kaiser, M; Kelly, JM; Mäser, P; Olmo, F | 1 |
| Couto, NRB; Frade, VP; Oliveira, CDL; Sanches, C; Simões, NS | 1 |
| Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC | 1 |
| Althabe, F; Belizán, JM; Bergel, E; Berrueta, M; Buekens, P; Cafferata, ML; Capparelli, EV; Ciganda, Á; Danesi, E; Dumonteil, E; Gibbons, L; Gulayin, PE; Herrera, C; Klein, K; Momper, JD; Rossi, S; Schijman, AG; Shaffer, JG; Sosa-Estani, S; Stella, CB; Toscani, MA | 1 |
| Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D | 1 |
| da Silva Nascimento, DDS; de Albuquerque Wanderley Sales, V; de Moura Ferraz, LR; de Souza Pereira, JJ; Ferreira, AS; Júnior, SA; Rolim, LA; Rolim-Neto, PJ; Silva, JYR; Tabosa, AÉGA | 1 |
| Alonso-Padilla, J; Alonso-Vega, C; Cortés-Serra, N; Gascón, J; Losada Galván, I; Pinazo, MJ | 1 |
| Apodaca Michel, B; Baptista Mora, A; Calizaya Tapia, NA; Du Plessis, JD; Lucuy Espinoza, M; Navarro, M; Oltmanns, K; Parisi, S; Pritsch, M; Rivera Rojas, AA; Rubilar, G; Saveedra Irala, C; Shock, JP; Terán, C; Zoller, T | 1 |
| Acharyya, N; Acosta, D; de Araujo, FF; Debrabant, A; Elói-Santos, SM; Martins-Filho, OA; Nagarkatti, R; Teixeira-Carvalho, A | 1 |
| Digirolamo, FA; Galceran, F; Miranda, MR; Pereira, CA; Reigada, C; Sayé, M; Valera-Vera, EA | 1 |
| Branquinho, RT; de Lana, M; Milagre, MM; Reis, LES; Silva, GN; Silva, RR; Silva, TM; Torchelsen, FKVDS | 1 |
| Corral, RS; Hernández, M; Pérez Caballero, E; Santamaría, MH; Wicz, S | 1 |
| Cunha-Neto, E; Kalil, J; Moore, CE; Nascimento, MS; Pandey, RP; Raj, VS | 1 |
| Acosta, N; Bobadilla, C; Escobar, P; Fernández, I; López, E; Ramírez, A; Yaluff, G | 1 |
| Búa, J; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Seremeta, KP | 1 |
| Gonzalez Garay, AG; Martinez Garcia, M; Reyes, PP; Vallejo, M | 1 |
| Amaral, BR; Argenta, DF; Caon, T; Enumo, A; Kroth, R; Parize, AL; Rauber, GS; Rebelatto, ERL; Saatkamp, RH | 1 |
| C B Q Figueiredo, R; Carrazone, C; Esmeraldo, AAM; G A M Cavalcanti, M; Gomes, YM; Higino, TMM; Júnior, WO; Lorena, VMB; Martins, SM; Moreira, LR; Nascimento, AV; Neves, PAF; Soares, AKA | 1 |
| Cotta-de-Almeida, V; de Araújo-Jorge, TC; de Meis, J; Ferreira-Reis, R; Lannes-Vieira, J; Marins-Dos-Santos, A; Olivieri, BP; Silva, AA | 1 |
| Alves da Silva, D; Chaves, LL; de Lima, LRM; de Paula, RCM; García-Villén, F; Hallwass, F; Oliveira, ACJ; Oliveira, TC; Ribeiro, FOS; Rolim-Neto, PJ; Silva-Filho, EC; Soares, MFR; Soares-Sobrinho, JL; Viseras, C | 1 |
| Batista, DDGJ; Cascabulho, C; de Almeida Fiuza, LF; Moreira, OC; Nunes, DF; Soeiro, MNC | 1 |
| Britto, C; Castaño Barrios, L; Cruz Moreira, O; Lannes-Vieira, J; Martins Batista, A; Mata Dos Santos, HA; Resende Pereira, I; Silva, AAD; Vilar-Pereira, G | 1 |
| Fukami, T; Honma, T; Inaoka, DK; Kita, K; Koyama, H; Matsuo, Y; Nakagawa, Y; Nara, T; Ogawa, N; Sekimata, K; Shirouzu, M; Tanaka, A; Tsuganezawa, K; Yuki, H | 1 |
| Carrilero, B; Egui, A; López, MC; López-Ruz, MÁ; Pérez-Antón, E; Segovia, M; Simón, M; Thomas, MC | 1 |
| Blaskovich, MAT; Kumeria, T; Ndayishimiye, J; Popat, A; Robert Falconer, J | 1 |
| Bottazzi, ME; Cruz-Chan, JV; Damania, A; González-López, C; Gusovsky, F; Hotez, PJ; Jones, KM; Keegan, B; Pollet, J; Versteeg, L; Villanueva-Lizama, LE; Villar, MJ | 1 |
| de Abreu, AP; de Ornelas Toledo, MJ; de Souza Fernandes, N; Lucas da Silva, HF; Sarto, MPM; Zanusso Junior, G | 1 |
| Busch, MP; Buss, LF; Franco, LAM; Lindoso, JAL; Manuli, ER; Martins, RCR; Moreira, CHV; Oliveira, LC; Pereira, AC; Sabino, EC | 1 |
| Albareda, MC; Alvarez, MG; Bertocchi, GL; Bua, J; Castro Eiro, MD; Cesar, G; Laucella, SA; Lococo, B; Natale, MA; Nuñez, M; Shen, H; Tarleton, RL; Viotti, R | 1 |
| Barnabé, C; Brenière, SF; Coral-Almeida, M; Costales, JA; Sereno, D; Vela, A | 1 |
| Arias, E; Bizai, ML; Bottasso, O; Fabbro, D; Marcipar, I; Olivera, V; Suasnabar, S | 1 |
| Almeida, IC; Alonso-Vega, C; Barboza, T; Barreira, F; Bilbe, G; Blum, B; Correia, E; Garcia, W; Gascón, J; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F; Vaillant, M | 1 |
| Engman, DM; Falk, BA; Li, X; Martinez, SJ; Olson, CL; Romano, PS; Scariot, DB; Scott, EA; Yi, S | 1 |
| da Silva Nascimento, DDS; de Moura Ferraz, LR; Ferreira, AS; Junior, SA; Rolim, LA; Rolim-Neto, PJ; Silva, JYR; Tabosa, AÉGA | 1 |
| Dattani, A; Drammeh, I; Mahmood, A; Rahman, M; Szular, J; Wilkinson, SR | 1 |
| Batista, LR; Correia, D; da Silva, DAA; da Silva, MV; de Resende, LAPR; de Sousa, RC; Helmo, FR; Lages-Silva, E; Llaguno, M; Machado, JR; Oliveira, CJF; Rodrigues, DBR; Rodrigues, V | 1 |
| Aoki, MP; Eberhardt, N; García, MC; Jimenez-Kairuz, AF; Ponce, NE; Sanmarco, LM | 1 |
| da Costa, KM; Freire-de-Lima, L; Mendonça-Previato, L; Previato, JO; Salustiano, EJ; Valente, RDC | 1 |
| García, LT; Moreno, EM; Pinto, SML; Quintero, WL; Sanabria, SM; Stashenko, E | 1 |
| Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Mota, SLA; Pereira, DE | 1 |
| Abegg, CP; de Abreu, AP; Fernandes, NS; Gomes, ML; Sarto, MPM; Teston, APM; Toledo, MJO | 1 |
| Bottari, NB; da Silva, AD; da Silva, AS; Fracasso, M; Monteiro, SG; Reichert, K; Schetinger, MRC | 1 |
| Alteri, E | 1 |
| Barreira, F; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F | 1 |
| Fortaleza, CMCB; Nunes da Costa, EAP; Victória, C | 1 |
| Cardona-Castro, N; García-Huertas, P | 1 |
| Bern, C; Cabeza, J; Castro, R; Clark, T; Gilman, RH; Lora, MH; Lozano, D; Mejia, C; Pajuelo, MJ; Reimer-McAtee, MJ; Terle, J; Torrico, F; Valencia, E | 1 |
| Carrilero, B; Gil-Gallardo, L; Iborra, A; Segovia, M; Simón, M | 1 |
| Alvedro, A; Bhattacharyya, T; Cardinal, MV; Enriquez, GF; Freilij, H; Gilleman, Q; Gürtler, RE; Macchiaverna, NP; Martinez de Salazar, P; Mertens, P; Miles, MA; Molina, I; Murphy, N | 1 |
| Barbosa, C; Carrillo, I; Castillo, C; Díaz-Araya, G; Fuentes-Retamal, S; González-Herrera, F; Guzmán-Rivera, D; Kemmerling, U; Machado, FS; Maya, JD; Quintero, H; Rabelo, RAN; Rates, M | 1 |
| Arrese-Muñoz, I; Aznar, ML; Bosch-Nicolau, P; Espinosa-Pereiro, J; Franco-Jarava, C; Molina, I; Oliveira-Souto, I; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre-Delcor, N; Sulleiro, E; Treviño, B; Valerio, L | 1 |
| Amendoeira, FC; Boniatti, J; Calil-Elias, S; Carr, O; da Fonseca, LB; da S Teixeira, RG; Dantas, FML; de A V Gandos, T; Ferreira, IAM; Oliveira, KC; Oliveira, ON; Rios, LPS; Santana, AKM; Shimizu, FM; Tappin, MRR; Viçosa, AL | 1 |
| Cevey, ÁC; Goren, NB; Mascolo, PD; Mirkin, GA; Penas, FN; Pieralisi, AV; Sequeyra, AS | 1 |
| Blondel, A; Coatnoan, N; Cosson, A; Cupif, JF; de Melo, GD; Gouault, N; Minoprio, P; Renault, J; Uriac, P | 1 |
| Brancaglion, GA; Caldas, IS; Caldas, S; Carvalho, DT; Diniz, LF; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, RRG; Silva, LS; Vilas-Boas, DF | 1 |
| Farani, PSG; Ferreira, BIS; Gibaldi, D; Lannes-Vieira, J; Moreira, OC | 1 |
| Bontempi, I; Cabrera, G; Cacik, P; Marcipar, I; Pacini, MF; Pérez Gianeselli, M; Pérez, AR; Prochetto, E; Rodeles, L; Vicco, M | 1 |
| Bedor, DCG; Frade, VP; Ghilard, FR; Moreira, CHV; Oliveira, CDL; Sabino, EC; Sanches, C | 1 |
| Barbosa, JMC; Cascabulho, CM; Daliry, A; de Melo, TG; de Oliveira, G; Pedra Rezende, Y; Pereira, ENGDS; Salem, KS | 1 |
| Breynaert, A; De Bruyne, T; Hermans, N; Huits, R; Truyens, C; Van Den Broucke, S; Van Esbroeck, M; Van Herreweghe, M | 1 |
| Carneiro, CM; Cunha, ELA; Fonseca, KDS; Lana, M; Pinto, KMC; Sousa, LRD; Torchelsen, FKVDS; Torres, RM; Vieira, PMA | 1 |
| Alvarez-Díaz, N; Arevalo-Rodriguez, I; Comeche, B; Crespillo-Andújar, C; Hamer, DH; Pérez-Molina, JA; Zamora, J | 1 |
| Arrua, EC; Goicoechea, H; Hartwig, O; Lehr, CM; Loretz, B; Murgia, X; Salomon, CJ | 1 |
| Sperandio da Silva, GM | 1 |
| Altcheh, J; Bisio, MMC; García-Bournissen, F; Gulin, JEN; Rocco, D; Solana, ME | 1 |
| Cardoso Santos, E; Dias Novaes, R; Lima, GDA; Oliveira Silva, R; Santana Nogueira, S; Vilela Gonçalves, R | 1 |
| Almeida, MC; Almeida-Silva, J; Andrade, SG; Fernandes, JMP; Menezes, DS; Perez, SAC; Saraiva, RM; Suarez-Fontes, AM; Vannier-Santos, MA; Vasco-Dos-Santos, DR; Viçosa, AL | 1 |
| Barbosa, HS; Barbosa, JMC; Daliry, A; de Castro, SL; de Melo, TG; Lannes-Vieira, J; Pedra-Rezende, Y; Pereira, LD; Salomão, K | 1 |
| Arana-Argaez, VE; Bottazzi, ME; Cruz-Chan, JV; Dumonteil, E; Dzul-Huchim, VM; Gusovsky, F; Hotez, P; Martinez-Vega, PP; Ortega-Lopez, J; Ramirez-Sierra, MJ; Rosado-Vallado, ME; Villanueva-Lizama, LE | 1 |
| Beccacece, A; Carrara, S; Comandini, UV; Corpolongo, A; Del Nonno, F; Giancola, ML; Maffongelli, G; Mariano, A; Montalbano, M; Nicastri, E; Petrone, A | 1 |
| Alcântara, L; Bortoluci, K; Cariste, LM; Castaño Barrios, L; Cunha-Neto, E; Franco, CH; Freitas-Junior, LH; Gibaldi, D; Kalil, J; Lannes-Vieira, J; Moraes, CB; Nascimento, MS; Pandey, RP; Silva, MN; Vasconcelos, JR; Zingales, B | 1 |
| Auckland, LD; Busselman, RE; Bustamante, JM; Collins, S; Hamer, SA; Malcolm, EL; Padilla, AM; Saunders, AB; Tarleton, RL; White, B; Wilson, BF | 1 |
| Altcheh, J; Ballering, G; Bochoeyer, A; Chatelain, E; Falk, N; Freilij, H; Garcia Bournissen, F; Goldsman, A; González, NL; Grippo, M; Jurado, L; Moroni, S; Moscatelli, G | 1 |
| Campos de Oliveira, L; Cerdeira Sabino, E; Cunha-Neto, E; Giordano, RJ; Kuramoto, A; Monteiro, JS; Rodriguez Carnero, LA; Setubal, JC | 1 |
| Baeza, I; Barrera-Aveleida, G; Galarce-Sosa, I; Gómez-Manzo, S; Meza-Toledo, S; Nevárez-Lechuga, I; Nogueda-Torres, B; Reséndiz-Mora, A; Santiago-Hernández, JC; Sotelo-Rodríguez, A; Wong-Baeza, C; Wong-Baeza, I | 1 |
| Altcheh, JM; Bournissen, FG; González, N; Moroni, S; Moscatelli, G; Pérez Montilla, CA; Rocco, DM | 1 |
| Lopes, MEASA; Murta, SMF; Ribeiro, JM; Souza-Fagundes, EM; Teixeira-Carvalho, A | 1 |
| Almeida, IC; Begum, K; Cardenas-Ovando, RA; Fernández-Figueroa, EA; Iandra da Silva Ferreira, B; Lannes-Vieira, J; Moreira, OC; Pereira, IR; Roy, S; Silva Grijó Farani, P; Vilar-Pereira, G | 1 |
| Assmann, CE; Bottari, NB; Castro, MFV; Chitolina Schetinger, MR; da Rocha, MIUM; da Silva, AS; da Veiga, ML; de Souza, LAF; Dutra da Silva, A; Ferreira, DASP; Fracasso, M; Gundel, S; Monteiro, SG; Morsch, VM; Ourique, AF; Reichert, KP | 1 |
| Auckland, LD; Bustamante, JM; Hamer, SA; Hodo, CL; McCain, S; Saunders, AB; Tarleton, RL; Wang, W; White, BE; Wilkerson, GK | 1 |
| da Silva Barros, M; de Arruda, TR; de Lorena, VMB; de Morais, CNL; Diniz, GTN; Dos Santos Oliveira, KK; Higino, TMM; Nascimento, AV; Rafael Moreira, L; Soares, AKA; Souza, VMO; Torres, DJL | 1 |
| Gonçalves, LO; Guimarães, PAS; Liarte, DB; Lima, DA; Murta, SMF; Reis-Cunha, JL; Ruiz, JC | 1 |
| Altcheh, J; Alves, F; Bisio, M; Caruso, M; Fernandes, J; Garcia-Bournissen, F; Gonzalez, N; Miranda, MR; Monla, C; Moran, L; Moroni, S; Moscatelli, G; Patiño, OL; Ramirez, T; Riarte, A; Ribeiro, I; Vaina, M; Valdez, M | 1 |
| Arruda, CCP; Baroni, ACM; Cardoso, IA; Carvalho, DB; Costa, PAN; das Neves, AR; de Albuquerque, S; Gaspari, PDM; Lopes, NP; Luccas, PH; Nonato, MC; Pelizaro, BI; Piranda, EM; Portapilla, GB; Shiguemoto, CYK; Silva, F | 1 |
| Caon, T; Conte, J; Dos Santos, BM; Parize, AL; Rauber, GS; Saatkamp, RH; Sanches, MP | 1 |
| Costa Oliveira, CND; Lorena, VMB; Moreira, LR; Nascimento, AV; Oliveira, KKDS; Paiva Cavalcanti, M; Saraiva, KLA; Silva Júnior, CDD; Silva, AC; Soares, AKA | 1 |
| Bottazzi, ME; Dean, DA; Hossain, E; Hotez, PJ; Jones, KM; Kane, SS; Kendricks, AL; Leão, AC; Liu, Z; McCall, LI; Pollet, J; Sankaranarayanan, K; Ulrich vonBargen, R; Wheeler, K | 1 |
| Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Olmo, F; Taylor, MC; Ward, AI | 1 |
76 review(s) available for benzonidazole and azomycin
| Article | Year |
|---|---|
Free radical metabolism of antiparasitic agents.
Topics: Animals; Chemical Phenomena; Chemistry; Free Radicals; Hydrogen Peroxide; Macromolecular Substances; Metronidazole; Nifurtimox; Niridazole; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Parasitic Diseases; Schistosoma mansoni; Superoxides; Tritrichomonas; Trypanosoma cruzi | 1986 |
Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas' disease).
Topics: Chagas Disease; Humans; Latin America; Nifurtimox; Nitrofurans; Nitroimidazoles | 1988 |
[Biochemical bases of the action of anti-chagasic drugs].
Topics: Allopurinol; Animals; Free Radicals; Gentian Violet; Glutathione; Humans; Nifurtimox; Nitroimidazoles; Oxidation-Reduction; Trypanocidal Agents; Trypanosoma cruzi | 1988 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi.
Topics: Animals; Anti-Bacterial Agents; Azoles; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1993 |
Chagas disease. American trypanosomiasis.
Topics: Animals; Chagas Disease; Heart; Humans; Immunocompromised Host; Interferon-gamma; Laboratory Infection; Mice; Nifurtimox; Nitroimidazoles; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi; United States | 1993 |
Reactivation of Chagas' disease in patients with AIDS: report of three new cases and review of the literature.
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Chagas Disease; Fatal Outcome; Female; Humans; Male; Middle Aged; Nitroimidazoles; Recurrence; Trypanocidal Agents; Trypanosoma cruzi | 1997 |
[Human American trypanosomiasis 90 years after its discovery by Carlos Chagas. II--Clinical aspects, physiopathology, diagnosis and treatment].
Topics: Brain Diseases; Chagas Cardiomyopathy; Chagas Disease; Child; Child, Preschool; Diagnosis, Differential; Disease Vectors; Double-Blind Method; Follow-Up Studies; Gastrointestinal Diseases; Humans; Immunization; Immunologic Deficiency Syndromes; Longitudinal Studies; Myocarditis; Nitroimidazoles; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Trypanocidal Agents; Vaccines | 1999 |
[Treatment of Trypanosoma cruzi infection in the indeterminate phase: experience and current guidelines in Argentina].
Topics: Adult; Argentina; Chagas Disease; Child; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1999 |
Contributions of toxicology to the problem of Chagas' disease (American Trypanosomiasis)--a year 2000 update.
Topics: Animals; Chagas Disease; Gentian Violet; Humans; Insect Vectors; Nifurtimox; Nitroimidazoles; Toxicology; Trypanocidal Agents | 2000 |
Clinical and epidemiological aspects of Chagas disease.
Topics: Adolescent; Adult; Chagas Disease; Electrocardiography; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents | 2001 |
A critical review on Chagas disease chemotherapy.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2002 |
Chemotherapy of Chagas' disease: status and new developments.
Topics: Animals; Chagas Disease; Drug Design; Enzyme Inhibitors; Humans; Nifurtimox; Nitroimidazoles; Phosphoenolpyruvate Carboxykinase (ATP); Reducing Agents; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Cerebral trypanosomiasis and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Central Nervous System Protozoal Infections; Fatal Outcome; Female; Humans; Nitroimidazoles; Tomography, X-Ray Computed; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 2002 |
Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Humans; Imidazoles; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2005 |
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
Topics: Acute-Phase Reaction; Animals; Chagas Disease; Ergosterol; Host-Parasite Interactions; Humans; Immunologic Factors; Mammals; Nifurtimox; Nitric Oxide; Nitroimidazoles; Purines; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis).
Topics: Animals; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2006 |
Pathogenesis of chronic Chagas heart disease.
Topics: Animals; Antibodies, Protozoan; Autoimmunity; Autonomic Nervous System; Chagas Cardiomyopathy; Cricetinae; Death, Sudden, Cardiac; Denervation; Heart; Heart Conduction System; Host-Parasite Interactions; Humans; Mice; Microcirculation; Models, Animal; Models, Cardiovascular; Models, Neurological; Molecular Mimicry; Myocardial Ischemia; Myocarditis; Myocardium; Nitroimidazoles; Parasympathetic Nervous System; T-Lymphocyte Subsets; Trypanocidal Agents; Trypanosoma cruzi; Vaccination; Ventricular Dysfunction, Left | 2007 |
An overview of Chagas disease treatment.
Topics: Chagas Disease; Health Services Accessibility; Humans; International Cooperation; Nifurtimox; Nitroimidazoles; Pan American Health Organization; Trypanocidal Agents | 2007 |
Chagas disease: clinical overview and implications for nursing.
Topics: Acute Disease; Animals; Canada; Chagas Disease; Chronic Disease; Emigration and Immigration; Hispanic or Latino; Humans; Immunologic Tests; Incidence; Insect Control; Insect Vectors; Nifurtimox; Nitroimidazoles; Nurse's Role; Prevalence; Primary Prevention; Risk Factors; South America; Travel; Triatoma; Trypanocidal Agents; United States | 2007 |
Benznidazole and Chagas disease: can an old drug be the answer to an old problem?
Topics: Adolescent; Adult; Chagas Disease; Child; Humans; Middle Aged; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2008 |
Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.
Topics: Argentina; Chagas Cardiomyopathy; Chagas Disease; Child; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities.
Topics: Age Factors; Animals; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
A systematic review of studies on heart transplantation for patients with end-stage Chagas' heart disease.
Topics: Allopurinol; Chagas Disease; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Neoplasms; Nitroimidazoles; Perioperative Care; Postoperative Complications; Recurrence; Trypanocidal Agents | 2009 |
Chagasic encephalitis in HIV patients: common presentation of an evolving epidemiological and clinical association.
Topics: Adult; Anticonvulsants; Antiretroviral Therapy, Highly Active; Chagas Disease; Female; HIV Infections; Humans; Immunocompromised Host; Meningoencephalitis; Nitroimidazoles; Seizures; Trypanocidal Agents | 2009 |
Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; Nitroimidazoles; Treatment Outcome; Young Adult | 2009 |
Recognizing and meeting the challenge of Chagas disease in the USA.
Topics: Chagas Disease; Guidelines as Topic; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States | 2009 |
Congenital transmission of Chagas disease: a clinical approach.
Topics: Adolescent; Adult; Animals; Antiprotozoal Agents; Chagas Disease; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Latin America; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanosoma cruzi; Young Adult | 2010 |
Current and developing therapeutic agents in the treatment of Chagas disease.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Time Factors; Treatment Outcome; Trypanocidal Agents | 2010 |
Chagas disease: Present status of pathogenic mechanisms and chemotherapy.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Current status of Chagas disease chemotherapy.
Topics: Adult; Animals; Chagas Disease; Child; Clinical Trials as Topic; Drug Administration Schedule; Humans; Latin America; Mice; Myocarditis; Nifurtimox; Nitroimidazoles; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
Antitrypanosomal therapy for chronic Chagas' disease.
Topics: Adult; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Humans; Life Cycle Stages; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
First century of Chagas' disease: an overview on novel approaches to nifurtimox and benzonidazole delivery systems.
Topics: Animals; Chagas Disease; Drug Delivery Systems; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
American trypanosomiasis (Chagas disease).
Topics: Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African | 2012 |
Immunosuppression and Chagas disease: a management challenge.
Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi | 2013 |
Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.
Topics: Chagas Disease; Drug Design; Humans; Indazoles; NADH, NADPH Oxidoreductases; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Potential new clinical therapies for Chagas disease.
Topics: Chagas Disease; Clinical Trials as Topic; Drug Discovery; Drug Therapy, Combination; Humans; Nifurtimox; Nitroimidazoles; Sterols; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis.
Topics: Animals; Chagas Disease; Humans; Lactones; Nanocapsules; Nanomedicine; Nitroimidazoles; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
A new era for chagas disease drug discovery?
Topics: 14-alpha Demethylase Inhibitors; Chagas Disease; Clinical Trials as Topic; Drug Discovery; Humans; Nitroimidazoles | 2015 |
Chronic Chagas disease with advanced cardiac complications in Japan: Case report and literature review.
Topics: Animals; Chagas Disease; Chronic Disease; Female; Heart Failure; Humans; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 2015 |
Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease.
Topics: Antigens, Protozoan; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Drug Discovery for Paediatric Chagas Disease.
Topics: Antiparasitic Agents; Chagas Disease; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2018 |
Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Child; Chronic Disease; Cohort Studies; Disease Progression; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Hemagglutination Tests; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Randomized Controlled Trials as Topic; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Xenodiagnosis | 2015 |
Developments in the management of Chagas cardiomyopathy.
Topics: Animals; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Disease Management; Electrocardiography; Heart Failure; Humans; Nanotechnology; Nitroimidazoles; Stem Cell Transplantation; Trypanocidal Agents; Vaccines | 2015 |
Chagas disease and transfusion medicine: a perspective from non-endemic countries.
Topics: Adult; Blood Donors; Blood Safety; Chagas Disease; Donor Selection; Emigration and Immigration; Enzyme-Linked Immunosorbent Assay; Europe; Female; Global Health; Health Services Needs and Demand; Humans; Infant, Newborn; Latin America; Male; Mass Screening; Nifurtimox; Nitroimidazoles; North America; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Transfusion Reaction; Travel; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Current drug therapy and pharmaceutical challenges for Chagas disease.
Topics: Americas; Chagas Disease; Humans; Life Cycle Stages; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
[What is not searched, it is difficult to find: Chagas' disease].
Topics: Chagas Cardiomyopathy; Chagas Disease; Emigrants and Immigrants; Humans; Italy; Neglected Diseases; Nifurtimox; Nitroimidazoles; Prevalence; South America; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Challenges in Chagas Disease Drug Discovery: A Review.
Topics: Chagas Disease; Clinical Trials as Topic; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Real-Time Polymerase Chain Reaction; RNA, Protozoan; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
Topics: Animals; Argentina; Biological Evolution; Chagas Disease; Drug Resistance; Genetic Variation; Genotype; Humans; Nifurtimox; Nitroimidazoles; Serologic Tests; Trypanosoma cruzi | 2018 |
Experimental and Clinical Treatment of Chagas Disease: A Review.
Topics: Animals; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Drug Compounding; Humans; Incidence; Latin America; Nanoparticles; Nifurtimox; Nitroimidazoles; Observational Studies as Topic; Randomized Controlled Trials as Topic; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole.
Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Delivery Systems; Humans; Nanoparticles; Nitroimidazoles; Solubility; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
An update on benznidazole for the treatment of patients with Chagas disease.
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Safety Profile of Benznidazole in the Treatment of Chronic Chagas Disease: Experience of a Referral Centre and Systematic Literature Review with Meta-Analysis.
Topics: Age Factors; Chagas Disease; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Nitroimidazoles; Prospective Studies; Sex Factors; Trypanocidal Agents | 2018 |
Clinical and pharmacological profile of benznidazole for treatment of Chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Humans; Neglected Diseases; Nitroimidazoles; Public Health; Trypanocidal Agents | 2018 |
Cardiac surgery for Chagas disease.
Topics: Cardiac Surgical Procedures; Chagas Cardiomyopathy; Echocardiography; Female; Heart Aneurysm; Heart Ventricles; Humans; Magnetic Resonance Imaging; Middle Aged; Nifurtimox; Nitroimidazoles; Serologic Tests; Stroke Volume; Treatment Outcome; Trypanocidal Agents | 2018 |
Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Humans; Life Cycle Stages; Mice; Models, Theoretical; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Dynamics of T Cells Repertoire During Trypanosoma cruzi Infection and its Post-Treatment Modulation.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Chronic Disease; Disease Progression; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Risk Factors; Trypanosoma cruzi | 2019 |
Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America.
Topics: Chagas Disease; Health Services Accessibility; Humans; Latin America; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
American Trypanosomiasis (Chagas Disease).
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Clinical Trials as Topic; Disease Progression; Disease Vectors; Humans; Nitroimidazoles; Triatominae; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review.
Topics: Chagas Disease; Dosage Forms; Humans; Nanostructures; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2019 |
Drug discovery for chagas disease: A viewpoint.
Topics: Chagas Disease; Drug Discovery; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Role of nucleic acid amplification assays in monitoring treatment response in chagas disease: Usefulness in clinical trials.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Drug Resistance; Humans; Nifurtimox; Nitroimidazoles; Nucleic Acids; Parasite Load; Real-Time Polymerase Chain Reaction; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Toxocariasis of the Nervous System.
Topics: Animals; Anthelmintics; Humans; Nervous System Diseases; Nitroimidazoles; Toxocariasis | 2020 |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review.
Topics: Adult; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis.
Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2020 |
New Approaches for the Treatment of Chagas Disease.
Topics: Animals; Chagas Disease; Drug Repositioning; Humans; Neglected Diseases; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Placebos; Randomized Controlled Trials as Topic; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis.
Topics: Chagas Disease; Drug Resistance; Genetic Variation; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets.
Topics: Animals; Chagas Disease; Drug Development; Drug Resistance; Humans; Medicine, Traditional; Molecular Targeted Therapy; Nifurtimox; Nitroimidazoles; Plant Preparations; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis.
Topics: Adult; Chagas Disease; Child; Humans; Nitroimidazoles; Observational Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Monotherapy and combination chemotherapy for Chagas disease treatment: a systematic review of clinical efficacy and safety based on randomized controlled trials.
Topics: Allopurinol; Chagas Disease; Drug Therapy, Combination; Humans; Nitroimidazoles; Randomized Controlled Trials as Topic; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
43 trial(s) available for benzonidazole and azomycin
| Article | Year |
|---|---|
Therapeutic efficacy of allopurinol in patients with chronic Chagas' disease.
Topics: Adult; Allopurinol; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1990 |
A randomized study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytoma. Report to the Medical Research Council by the Brain Tumor Working Party.
Topics: Adolescent; Adult; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Prognosis; Random Allocation | 1989 |
[Peripheral polyneuropathy induced by benzonidazole in the treatment of Chagas' disease].
Topics: Adult; Chagas Disease; Clinical Trials as Topic; Electromyography; Female; Humans; Male; Middle Aged; Nitroimidazoles; Peripheral Nerves; Polyneuropathies; Trypanocidal Agents | 1986 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Clinical trial of benznidazole and an immunopotentiator against Chagas disease in Chile.
Topics: Anti-Infective Agents; Chagas Cardiomyopathy; Clinical Trials as Topic; Double-Blind Method; Humans; Immunoglobulins; Nitroimidazoles; Trypanocidal Agents | 1986 |
[Treatment of Chagas' disease].
Topics: Animals; Cats; Chagas Disease; Clinical Trials as Topic; Cricetinae; Dogs; Guinea Pigs; Humans; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Rats; Trypanocidal Agents; Trypanosoma cruzi | 1985 |
[Allopurinol in the treatment of chronic Chagas' disease].
Topics: Allopurinol; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1985 |
Benznidazole with CCNU: a clinical phase I toxicity study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Brain Neoplasms; Drug Evaluation; Humans; Lomustine; Nitroimidazoles | 1985 |
[Use of thioctic acid for prevention of the adverse effects induced by benznidazole in patients with chronic Chagas' infection].
Topics: Chagas Disease; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Male; Nitroimidazoles; Thioctic Acid | 1983 |
Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection.
Topics: Animals; Antibodies, Protozoan; Brazil; Chagas Disease; Child; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Hemagglutination Tests; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1996 |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.
Topics: Chagas Disease; Child; Double-Blind Method; Humans; Nitroimidazoles; Trypanocidal Agents | 1998 |
Soluble platelet selectin (sP-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease during therapy with benznidazole in children with indeterminate form of Chagas' disease.
Topics: Chagas Disease; Child; Double-Blind Method; Humans; Nitroimidazoles; P-Selectin; Regression Analysis; Trypanocidal Agents; Vascular Cell Adhesion Molecule-1 | 1999 |
[Treatment of Chagas disease with benznidazole and thioctic acid].
Topics: Administration, Oral; Adolescent; Adult; Animals; Antioxidants; Chagas Disease; Drug Therapy, Combination; Epidemiologic Research Design; Female; Humans; Male; Nitroimidazoles; Thioctic Acid; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Short report: benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up.
Topics: Adolescent; Adolescent Health Services; Adult; Animals; Antigens, Protozoan; Chagas Disease; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Randomized Controlled Trials as Topic; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
[Integral treatment of congenital Chagas disease: the Bolivian experience ].
Topics: Chagas Disease; Clinical Protocols; Comprehensive Health Care; Family; Follow-Up Studies; Humans; Infant; Infant, Newborn; Nitroimidazoles; Patient Compliance; Prospective Studies; Treatment Outcome; Trypanocidal Agents | 2005 |
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial.
Topics: Adult; Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prognosis; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile.
Topics: Adolescent; Animals; Case-Control Studies; Chagas Disease; Child; Cytokines; Female; Gene Expression; Humans; Immunity, Innate; Longitudinal Studies; Male; Nitroimidazoles; Trypanosoma cruzi | 2006 |
Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).
Topics: Chagas Cardiomyopathy; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Latin America; Male; Nitroimidazoles; Pilot Projects; Risk Assessment; Severity of Illness Index; Survival Analysis; Time Factors; Treatment Outcome; Trypanosomiasis | 2008 |
Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.
Topics: Adult; CD8-Positive T-Lymphocytes; Chagas Disease; Flow Cytometry; Humans; Interferon-gamma; Interleukin-2; Middle Aged; Nitroimidazoles; T-Lymphocytes; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
Antibody drop in newborns congenitally infected by Trypanosoma cruzi treated with benznidazole.
Topics: Antibodies, Protozoan; Chagas Disease; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Nitroimidazoles; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Tolerance of benznidazole in treatment of Chagas' disease in adults.
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2010 |
Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study.
Topics: Adult; Allopurinol; Antiprotozoal Agents; B-Lymphocytes; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Pilot Projects; T-Lymphocytes; Treatment Outcome; Trypanosoma cruzi | 2013 |
Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia.
Topics: Bolivia; Chagas Disease; Guideline Adherence; Humans; Infant, Newborn; Medication Adherence; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Improved completion rates and characterization of drug reactions with an intensive Chagas disease treatment program in rural Bolivia.
Topics: Adolescent; Adult; Antiprotozoal Agents; Bolivia; Chagas Disease; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Medication Adherence; Middle Aged; Nitroimidazoles; Prospective Studies; Rural Population; Treatment Outcome; Young Adult | 2013 |
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.
Topics: Adult; Chagas Disease; Chronic Disease; DNA, Protozoan; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Transaminases; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Population pharmacokinetic study of benznidazole in pediatric Chagas disease suggests efficacy despite lower plasma concentrations than in adults.
Topics: Adult; Chagas Disease; Child; Child, Preschool; Female; Humans; Linear Models; Male; Nitroimidazoles; Trypanocidal Agents | 2014 |
Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease.
Topics: Adult; Breast Feeding; Chagas Disease; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Milk, Human; Nitroimidazoles; Prospective Studies; Young Adult | 2015 |
Population pharmacokinetics of benznidazole in adult patients with Chagas disease.
Topics: Adult; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2015 |
Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.
Topics: Adult; Aged; Cardiovascular Diseases; Chagas Cardiomyopathy; Chronic Disease; Disease Progression; Female; Genotype; Humans; Male; Middle Aged; Nitroimidazoles; Parasite Load; Polymerase Chain Reaction; Proportional Hazards Models; Prospective Studies; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study.
Topics: Adolescent; Argentina; Chagas Cardiomyopathy; Child; Cohort Studies; Double-Blind Method; Electrocardiography; Female; Humans; Male; Nitroimidazoles; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Changes in the immune response after treatment with benznidazole versus no treatment in patients with chronic indeterminate Chagas disease.
Topics: Adult; Aged; Biomarkers; Chagas Disease; Chronic Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Pharmacokinetics and Tissue Distribution of Benznidazole after Oral Administration in Mice.
Topics: Administration, Oral; Adolescent; Adult; Animals; Chagas Disease; Chromatography, High Pressure Liquid; Female; Humans; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2017 |
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial.
Topics: Administration, Oral; Adult; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Single-Blind Method; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
What to expect and when: benznidazole toxicity in chronic Chagas' disease treatment.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chagas Disease; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Trypanocidal Agents; Young Adult | 2018 |
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2018 |
Distinct Treatment Outcomes of Antiparasitic Therapy in
Topics: Adolescent; Chagas Disease; Chemokines; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Parasitemia; T-Lymphocytes; Trypanosoma cruzi | 2018 |
Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment.
Topics: Adolescent; Adult; Area Under Curve; Calibration; Chagas Disease; Chromatography, Liquid; Dried Blood Spot Testing; Drug Stability; Female; Humans; Male; Middle Aged; Nitroimidazoles; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.
Topics: Adolescent; Bacteria; Bolivia; Chagas Disease; Child; Child, Preschool; Feces; Female; Humans; Male; Microbiota; Mouth Mucosa; Nitroimidazoles; Rural Population; Skin | 2019 |
Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial.
Topics: Adult; Aged; Asymptomatic Diseases; Chagas Disease; Colombia; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nifurtimox; Nitroimidazoles; Randomized Controlled Trials as Topic; Therapeutic Equivalency; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial.
Topics: Adult; Aftercare; Argentina; Brazil; Case-Control Studies; Chagas Disease; Chronic Disease; Colombia; Double-Blind Method; Female; Humans; Male; Neglected Diseases; Nitroimidazoles; Parasite Load; Safety; Spain; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Short-course Benznidazole treatment to reduce Trypanosoma cruzi parasitic load in women of reproductive age (BETTY): a non-inferiority randomized controlled trial study protocol.
Topics: Argentina; Chagas Disease; Female; Humans; Nitroimidazoles; Parasite Load; Postpartum Period; Pregnancy; Randomized Controlled Trials as Topic; Real-Time Polymerase Chain Reaction; Retrospective Studies; Trypanosoma cruzi | 2020 |
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial.
Topics: Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nitroimidazoles; Parasite Load; Treatment Outcome; Triazoles; Young Adult | 2021 |
750 other study(ies) available for benzonidazole and azomycin
| Article | Year |
|---|---|
Benznidazole-induced ultrastructural alterations in rat adrenal cortex. Mechanistic studies.
Topics: Administration, Oral; Adrenal Cortex; Animals; Male; Microscopy, Electron; Microsomes; Mitochondria; Mutagens; Nitroimidazoles; Nitroreductases; Rats; Rats, Inbred Strains; Subcellular Fractions | 1992 |
Trypanocidal drugs and their effect on parasitaemia, specific IgG production and protective immunity in rats infected with Trypanosoma lewisi.
Topics: Animals; Antibodies, Protozoan; Diminazene; Ethidium; Female; Immunoglobulin G; Nifurtimox; Nitroimidazoles; Rats; Rats, Inbred F344; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis | 1992 |
Evaluation of the mutagenic potential of the antichagasic drug Rochagan in healthy and chagasic rodents.
Topics: Acute Disease; Animals; Bone Marrow; Bone Marrow Cells; Chagas Disease; Chromosome Aberrations; Chromosomes; Chronic Disease; Dose-Response Relationship, Drug; Mice; Mice, Inbred BALB C; Micronucleus Tests; Nitroimidazoles; Rats; Rats, Inbred Strains; Time Factors; Trypanocidal Agents | 1991 |
Shift of excretory-secretory immunogens of Trypanosoma cruzi during human Chagas' disease.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Antigens, Protozoan; Chagas Disease; Chronic Disease; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Nitroimidazoles; Rabbits; Trypanocidal Agents; Trypanosoma cruzi | 1991 |
Experimental chemotherapy of Trypanosoma cruzi infection: persistence of parasite antigens and positive serology in parasitologically cured mice.
Topics: Animals; Antigens, Protozoan; Chagas Disease; Mice; Microscopy, Immunoelectron; Nifurtimox; Nitroimidazoles; Spleen; Trypanocidal Agents | 1991 |
Lack of sensitivity of sister-chromatid exchange for lymphocyte chromosomal damage detection caused by antichagasic treatment.
Topics: Chagas Disease; Child; Child, Preschool; Chromosomes; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes; Male; Nifurtimox; Nitroimidazoles; Sister Chromatid Exchange; Trypanocidal Agents | 1991 |
Chagas' disease: lymphoma growth in rabbits treated with Benznidazole.
Topics: Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Female; Hypersensitivity, Delayed; Immunity, Cellular; Intradermal Tests; Liver; Lymphoma, Non-Hodgkin; Male; Molecular Structure; Myocardium; Nitroimidazoles; Rabbits; Trypanocidal Agents; Trypanosoma cruzi | 1990 |
Trypanocidal nitroarene treatment of experimental Trypanosoma cruzi infection does not prevent progression of chronic-phase heart lesions in rabbits.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Nifurtimox; Nitroimidazoles; Rabbits; Trypanocidal Agents | 1990 |
Pituitary-testicular axis in benznidazole-treated rats.
Topics: Animals; Antiprotozoal Agents; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Nitroimidazoles; Prolactin; Rats; Testis; Testosterone | 1990 |
Malignant, non-Hodgkin's lymphomas in Trypanosoma cruzi-infected rabbits treated with nitroarenes.
Topics: Animals; Chagas Cardiomyopathy; Female; Injections, Intraperitoneal; Lymphoma, Non-Hodgkin; Male; Myocarditis; Myositis; Nifurtimox; Nitrofurans; Nitroimidazoles; Rabbits; Trypanosoma cruzi | 1990 |
Synergistic activity of 5-substituted 2-nitroimidazoles (Ro 15-0216 and benznidazole) and DL-alpha-difluoromethylornithine on Trypanosoma brucei brucei.
Topics: Acetanilides; Animals; Drug Synergism; Eflornithine; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei brucei | 1990 |
Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections.
Topics: Animals; Chagas Disease; Ferredoxins; Microsomes, Liver; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Rats; Subcellular Fractions; Thiadiazoles; Trypanosoma cruzi | 1989 |
[Chagas' disease in patients with renal transplantation].
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Immune Tolerance; Kidney Transplantation; Male; Nifurtimox; Nitroimidazoles; Serologic Tests; Transfusion Reaction; Trypanocidal Agents | 1989 |
Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Diazooxonorleucine; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Methionine Sulfoximine; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1989 |
Effects of nitroheterocyclic drugs on macromolecule synthesis and degradation in Trypanosoma cruzi.
Topics: Animals; DNA; Leucine; Macromolecular Substances; Nifurtimox; Nitro Compounds; Nitroimidazoles; Protein Biosynthesis; Proteins; RNA; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Uridine | 1985 |
[Nifurtimox and benznidazole inhibit DNA and protein synthesis in rat hepatocytes].
Topics: Animals; DNA; Liver; Male; Nifurtimox; Nitrofurans; Nitroimidazoles; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1988 |
Testes alterations in pubertal benznidazole-treated rats.
Topics: Animals; Atrophy; Male; Nitroimidazoles; Organ Size; Prostate; Rats; Rats, Inbred Strains; Seminal Vesicles; Spermatogenesis; Testis; Testosterone; Trypanocidal Agents | 1989 |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi.
Topics: Animals; Crithidia; In Vitro Techniques; Nifurtimox; Nitrofurans; Nitroimidazoles; Protein Biosynthesis; Trypanocidal Agents; Trypanosoma cruzi | 1989 |
Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.
Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytosol; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1989 |
Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.
Topics: Amines; Animals; Hyperthermia, Induced; Liver; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Oxidation-Reduction | 1989 |
Ultrastructural alterations in ovaries from nifurtimox or benznidazole-treated rats: their relation to ovarian nitroreductive biotransformation of both drugs.
Topics: Animals; Biotransformation; Cytosol; Female; Microscopy, Electron; Microsomes; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Ovary; Oxidoreductases; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1989 |
Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole.
Topics: Bacteria; Bacteria, Aerobic; Bacteria, Anaerobic; Microbial Sensitivity Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1989 |
The reductive metabolism of nifurtimox and benznidazole in Crithidia fasciculata is similar to that in Trypanosoma cruzi.
Topics: Animals; Crithidia; Free Radicals; Mitochondria; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Trypanocidal Agents; Trypanosoma cruzi | 1988 |
Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi.
Topics: Animals; Cell Nucleus; DNA; Lipid Metabolism; Nitroimidazoles; Proteins; Trypanosoma cruzi | 1988 |
Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Drug Resistance; Macrophages; Male; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 1988 |
Trypanosoma cruzi: zymodemes associated with acute and chronic Chagas' disease in central Brazil.
Topics: Adolescent; Adult; Brazil; Chagas Disease; Child; Child, Preschool; Drug Resistance; Female; Humans; Isoenzymes; Male; Middle Aged; Nitroimidazoles; Seasons; Trypanocidal Agents; Trypanosoma cruzi | 1986 |
Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytosol; Kidney; Kinetics; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Neoplasms, Experimental; Nitroimidazoles; Nitroreductases; Oxidoreductases | 1987 |
[Tolerance to benzonidazole during the etiological treatment of Chagas' disease].
Topics: Adult; Animals; Body Weight; Chagas Cardiomyopathy; Chagas Disease; Drug Tolerance; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanosoma cruzi | 1987 |
Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Male; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1987 |
Assessment of cytogenetic damage in chagasic children treated with benznidazole.
Topics: Cell Nucleus; Chagas Disease; Child; Child, Preschool; Chromosome Aberrations; DNA Damage; Female; Humans; Infant; Lymphocytes; Male; Mutagens; Nitroimidazoles; Trypanocidal Agents | 1988 |
[Chagas' disease: clastogenic effect of nifurtimox and benznidazole in children].
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Chromosome Banding; Chromosome Fragility; Humans; Infant; Metaphase; Micronucleus Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1988 |
Evaluation of genotoxic activity in the blood and urine of guinea pigs treated with nifurtimox and benznidazole.
Topics: Animals; Female; Guinea Pigs; Male; Mutagenicity Tests; Mutation; Nifurtimox; Nitrofurans; Nitrofurantoin; Nitroimidazoles | 1988 |
[Preparation and characterization of prodrugs of the potential schistosomicid praziquantel].
Topics: Animals; Chemical Phenomena; Chemistry; Mannich Bases; Mice; Nitroimidazoles; Nitroquinolines; Oxamniquine; Praziquantel; Prodrugs; Schistosoma mansoni; Trypanocidal Agents | 1988 |
Activation of anti-Trypanosoma cruzi drugs to genotoxic metabolites promoted by mammalian microsomal enzymes.
Topics: Animals; Biotransformation; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Rats; Salmonella typhimurium; Trypanosoma cruzi | 1988 |
Liver microsomal benznidazole and nifurtimox nitroreductase activity in male rats of different age.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1987 |
Mutagenicity of nifurtimox and benznidazole in the Salmonella/microsome assay.
Topics: Mutagenicity Tests; Mutagens; Nifurtimox; Nitrofurans; Nitroimidazoles; Salmonella typhimurium | 1986 |
Genotoxicity studies with two antichagasic drugs.
Topics: Drug Resistance, Microbial; Escherichia coli; Lysogeny; Mutagenicity Tests; Mutation; Nifurtimox; Nitrofurans; Nitroimidazoles; Salmonella typhimurium; SOS Response, Genetics; Trypanocidal Agents | 1987 |
Sister-chromatid exchange in spleenic lymphocytes of mice after exposure to nifurtimox or benznidazole.
Topics: Animals; Lymphocytes; Male; Mice; Mutagenicity Tests; Nifurtimox; Nitrofurans; Nitroimidazoles; Sister Chromatid Exchange; Spleen | 1987 |
Misonidazole and benznidazole inhibit hydroxylation of CCNU by mouse liver microsomal cytochrome P-450 in vitro.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Misonidazole; Nitroimidazoles; Structure-Activity Relationship | 1987 |
Heat-stimulated nitroreductive bioactivation of the 2-nitroimidazole benznidazole in vitro.
Topics: Animals; Fibrosarcoma; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Nitrate Reductase; Nitrate Reductases; Nitroimidazoles | 1987 |
Species and sex differences in the liver microsomal nitroreductive biotransformation of nifurtimox and benznidazole.
Topics: Animals; Biotransformation; Cricetinae; Female; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Mice; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Trypanocidal Agents | 1987 |
Interaction of benznidazole reactive metabolites with rat liver deoxyribonucleic acid and nuclear proteins.
Topics: Animals; Cell Nucleus; DNA; Liver; Male; Microsomes, Liver; NADP; Nitroimidazoles; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1986 |
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069.
Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1986 |
A phase II study of CCNU with benznidazole for metastatic malignant melanoma.
Topics: Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Lomustine; Melanoma; Nitroimidazoles | 1986 |
Effects of nifurtimox or benznidazole administration on rat testes: ultrastructural observations and biochemical studies.
Topics: Animals; Biotransformation; Cytosol; Endoplasmic Reticulum; Lipid Peroxides; Male; Microscopy, Electron; Microsomes; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Organoids; Phospholipids; Protein Binding; Rats; Rats, Inbred Strains; Sertoli Cells; Spermatozoa; Testis | 1986 |
Benznidazole and nifurtimox nitroreductase activity in liver microsomes from male rats preinduced with phenobarbital or 3-methylcholanthrene.
Topics: Animals; Biotransformation; Male; Methylcholanthrene; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Reactions of nitroimidazoles with free radicals--enhancement of reaction by u.v. irradiation.
Topics: Acrylic Resins; Free Radicals; Metronidazole; Misonidazole; Mutagens; Nitroimidazoles; Ornidazole; Potassium; Potassium Compounds; Radiation-Sensitizing Agents; Sulfates; Ultraviolet Rays | 1985 |
Damage of Trypanosoma cruzi deoxyribonucleic acid by nitroheterocyclic drugs.
Topics: Animals; DNA; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1985 |
Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types.
Topics: Animals; Chagas Disease; Mice; Nifurtimox; Nitrofurans; Nitroimidazoles; Species Specificity; Trypanocidal Agents | 1985 |
Benznidazole: nitroreduction and inhibition of cytochrome P-450 in chemosensitization of tumour response to cytotoxic drugs.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Kinetics; Lomustine; Mice; Microsomes, Liver; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1986 |
Studies on pentane evolution by rats treated with nifurtimox or benznidazole.
Topics: Animals; Carbon Tetrachloride; Lipid Peroxides; Male; Nifurtimox; Nitrofurans; Nitroimidazoles; Pentanes; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1985 |
Micronucleus formation in bone marrow of mice treated with nifurtimox or benznidazole.
Topics: Animals; Bone Marrow; Cell Nucleus; Male; Mice; Mutagens; Nifurtimox; Nitrofurans; Nitroimidazoles; Trypanocidal Agents | 1985 |
Effect of lipophilicity on the rate of diffusion of sensitizers into cellular targets.
Topics: Animals; Cell Survival; Cricetinae; Cricetulus; Diffusion; Membrane Lipids; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1985 |
Effect of benznidazole on the mixed function oxygenase system from rat liver microsomes.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Kinetics; Lipid Metabolism; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADH Dehydrogenase; Nitroimidazoles; Pentobarbital; Rats; Rats, Inbred Strains; Sleep; Time Factors; Trypanocidal Agents | 1985 |
[Different effects of nifurtimox and benznidazole on the biosynthesis of DNA, RNA and proteins in Trypanosoma cruzi].
Topics: Animals; DNA; Nifurtimox; Nitrofurans; Nitroimidazoles; Protein Biosynthesis; RNA; Trypanocidal Agents; Trypanosoma cruzi | 1984 |
[Effects of nifurtimox, benznidazole, and beta-lapachone on the metabolism of DNA, RNA and proteins in Trypanosoma cruzi].
Topics: Animals; Depression, Chemical; DNA; DNA Damage; Free Radicals; Naphthoquinones; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxygen; Protein Biosynthesis; RNA; Trypanocidal Agents; Trypanosoma cruzi | 1983 |
Difference of effective antitrypanosomal dosages of benznidazole in mice and man. Chemotherapeutic and pharmacokinetic results.
Topics: Adult; Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Middle Aged; Nitroimidazoles; Trypanocidal Agents | 1980 |
Effect of the trypanosomicide benznidazole on various enzymatic systems.
Topics: Animals; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Microsomes, Liver; Monoamine Oxidase; Nitroimidazoles; Norepinephrine; Pentobarbital; Phenylethanolamine N-Methyltransferase; Sleep; Tyrosine 3-Monooxygenase | 1983 |
Trypanosoma cruzi: a pharmacological comparison of some Bolivian isoenzymic strains.
Topics: 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole; Animals; Microbial Sensitivity Tests; Nitrofurans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1983 |
Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etanidazole; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics.
Topics: Animals; Antineoplastic Agents; Carmustine; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Semustine; Streptozocin; Time Factors | 1984 |
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations.
Topics: Animals; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen Peroxide; Kinetics; Male; Microsomes; Mitochondria, Liver; Nitroimidazoles; Rats; Rats, Inbred Strains; Species Specificity; Superoxides; Trypanocidal Agents; Trypanosoma cruzi | 1982 |
Ketoconazole and other potent antimycotic azoles exhibit pronounced activity against Trypanosoma cruzi, Plasmodium berghei and Entamoeba histolytica in vivo.
Topics: Amebiasis; Animals; Antifungal Agents; Chagas Disease; Entamoeba histolytica; Entamoebiasis; Ketoconazole; Malaria; Mice; Nitroimidazoles; Plasmodium berghei; Trypanosoma cruzi | 1984 |
[Undesirable effects of benznidazole and nifurtimox].
Topics: Animals; Hydrogen Peroxide; In Vitro Techniques; Microsomes, Liver; NADP; Nifurtimox; Nitrofurans; Nitroimidazoles; Oxygen Consumption; Rats; Superoxides; Trypanosoma cruzi | 1983 |
[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].
Topics: Animals; DNA; DNA Damage; DNA Repair; Free Radicals; Naphthoquinones; Nifurtimox; Nitroimidazoles; Oxidation-Reduction; Trypanocidal Agents; Trypanosoma cruzi | 1984 |
Chronic Chagas' disease in the mouse. IV. Effect of trypanocidal drugs.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Female; Intestinal Diseases, Parasitic; Mice; Mice, Inbred Strains; Myositis; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1983 |
Administration of benznidazole, a chemotherapeutic agent against Chagas disease, to pregnant rats. Covalent binding of reactive metabolites to fetal and maternal proteins.
Topics: Animals; Chagas Disease; Female; Fetus; Mutagens; Nitroimidazoles; Placenta; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Solubility; Tissue Distribution | 1984 |
[Benznidazole and chronic Chagas disease].
Topics: Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 1984 |
[Thioctic acid in the prevention of the toxic effects of benznidazole].
Topics: Chagas Disease; Humans; Nitroimidazoles; Thioctic Acid; Trypanocidal Agents | 1984 |
Preclinical pharmacokinetics of benznidazole.
Topics: Animals; Antineoplastic Agents; Brain; Chromatography, High Pressure Liquid; Dogs; Drug Evaluation, Preclinical; Female; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Pharmaceutical Vehicles; Sheep | 1984 |
A phase I study of the combination of benznidazole and CCNU in man.
Topics: Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Lomustine; Neoplasms; Nitroimidazoles; Trypanocidal Agents | 1984 |
Effect of nitroheterocyclic drugs on lipid peroxidation and glutathione content in rat liver extracts.
Topics: Animals; Free Radicals; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Male; Malondialdehyde; Nifurtimox; Nitrofurans; Nitroimidazoles; Rats; Rats, Inbred Strains; Tissue Extracts; Trypanocidal Agents | 1984 |
Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069.
Topics: Animals; Aziridines; Azirines; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
A rapid-mix study on the effect of lipophilicity of nitroimidazoles on the radiosensitization of mammalian cells in vitro.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1983 |
Nitroreduction of benznidazole and nifurtimox by rat and human feces.
Topics: Animals; Feces; Humans; Male; Neomycin; Nifurtimox; Nitro Compounds; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Reductive metabolism and activation of benznidazole, a drug against Chagas' disease.
Topics: Animals; Biotransformation; In Vitro Techniques; Male; Microsomes, Liver; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1983 |
Reductive metabolism and activation of benznidazole.
Topics: Animals; Biotransformation; Cytosol; Flavin-Adenine Dinucleotide; Male; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Protein Binding; Rats; Rats, Inbred Strains; Trypanocidal Agents | 1984 |
Multiple-dose kinetics of the trypanosomicide benznidazole in man.
Topics: Adult; Chagas Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nitroimidazoles | 1980 |
The efficacy of a novel compound, (e)-1-(4'-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene against Trypanosoma cruzi in mice.
Topics: Animals; Biphenyl Compounds; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1982 |
[Treatment of Chagas disease].
Topics: Amphotericin B; Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1981 |
Effect of specific chemotherapy on the levels of lytic antibodies in Chagas's disease.
Topics: Animals; Antibodies; Chagas Disease; Complement System Proteins; Humans; Male; Mice; Mice, Inbred Strains; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1982 |
A nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections.
Topics: Animals; Chagas Disease; Drug Administration Schedule; Male; Mice; Mice, Inbred Strains; Nitrofurazone; Nitroimidazoles; Thiadiazoles; Trypanocidal Agents | 1982 |
[Etiological treatment of Chagas' disease].
Topics: Animals; Chagas Disease; Humans; Mice; Nifurtimox; Nitrofurans; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 1982 |
[Chagas disease and pregnancy. Review apropos of a clinical case. Treatment].
Topics: Adult; Chagas Disease; Female; Humans; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious | 1981 |
In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1983 |
Chemosensitization by lipophilic nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study.
Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antibody Technique; Injections, Intraperitoneal; Injections, Intravenous; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
[Undesirable effects of nifurtimox and benznidazole].
Topics: Humans; Nifurtimox; Nitrofurans; Nitroimidazoles | 1982 |
Cytogenetic effects of the antichagasic benznidazole on human cells in vitro.
Topics: Carcinoma, Hepatocellular; Cell Line; Chromosome Aberrations; Humans; Lymphocytes; Micronucleus Tests; Nitroimidazoles; Sister Chromatid Exchange; Trypanocidal Agents; Tumor Cells, Cultured | 1994 |
The anticlastogenic effect of tocopherol in peritoneal macrophages of benznidazole-treated and ovariectomized mice.
Topics: Analysis of Variance; Animals; Antimutagenic Agents; Chromosome Aberrations; Chromosome Banding; Chromosome Deletion; Female; Macrophages, Peritoneal; Mice; Mitosis; Mutagenicity Tests; Mutagens; Nitroimidazoles; Ovariectomy; Trypanocidal Agents; Vitamin E | 1994 |
Chagas' disease: carcinogenic activity of the antitrypanosomal nitroarenes in mice.
Topics: Animals; Carcinogens; Cell Division; Chagas Disease; Female; Liver; Lymph Nodes; Lymphoma; Mice; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1994 |
Severe myocarditis and esophagitis during reversible long standing Chagas' disease recrudescence in immunocompromised host.
Topics: Adult; Chagas Cardiomyopathy; Esophagitis; Female; Humans; Immunocompromised Host; Nitroimidazoles; Trypanocidal Agents; Ultrasonography | 1995 |
Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation.
Topics: Animals; Antibodies, Protozoan; Base Sequence; Chagas Disease; DNA, Kinetoplast; Humans; Molecular Sequence Data; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanosoma cruzi | 1995 |
Chagasic meningoencephalitis with detection of Trypanosoma cruzi in the cerebrospinal fluid of an immunodepressed patient.
Topics: Adult; Animals; Cerebrospinal Fluid; Chagas Disease; Humans; Immunocompromised Host; Immunosuppression Therapy; Kidney Transplantation; Male; Meningoencephalitis; Nitroimidazoles; Recurrence; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Antibodies inhibiting Trypanosoma cruzi trans-sialidase activity in sera from human infections.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Antigens, Protozoan; Chagas Disease; Chronic Disease; Female; Glycoproteins; Humans; Immune Sera; Infant, Newborn; Neuraminidase; Neutralization Tests; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Effects of immunosuppression and benzonidazole on Trypanosoma cruzi parasitism during experimental acute Chagas' disease.
Topics: Animals; Chagas Disease; Cyclosporine; Heart; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Prednisone; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Use of Trypanosoma cruzi purified glycoprotein (GP57/51) or trypomastigote-shed antigens to assess cure for human Chagas' disease.
Topics: Acute Disease; Adsorption; Adult; Animals; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Chagas Disease; Child; Chronic Disease; Cross Reactions; Cysteine Endopeptidases; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Follow-Up Studies; Glycoproteins; Humans; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 1993 |
Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up.
Topics: Adult; Aged; Animals; Antibodies, Protozoan; Chagas Disease; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Serologic Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 1994 |
Successful treatment of Trypanosoma cruzi encephalitis in a patient with hemophilia and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Chagas Disease; Drug Therapy, Combination; Encephalitis; Fluconazole; Hemophilia A; Humans; Itraconazole; Ketoconazole; Male; Nitroimidazoles; Transfusion Reaction; Trypanocidal Agents | 1993 |
Long-term follow-up after heart transplantation in Chagas' disease.
Topics: Actuarial Analysis; Adrenal Cortex Hormones; Adult; Azathioprine; Chagas Cardiomyopathy; Chagas Disease; Cyclosporine; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Male; Necrosis; Nitroimidazoles; Retrospective Studies; Survival Analysis; Time Factors; Treatment Outcome; Trypanocidal Agents | 1993 |
Chelating agent inhibition of Trypanosoma cruzi epimastigotes in vitro.
Topics: Animals; Carbamates; Cell Division; Chagas Disease; Chelating Agents; Disulfides; Dose-Response Relationship, Drug; Ethylenediamines; Metals; Molecular Structure; Nitroimidazoles; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi | 1995 |
Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Nitroimidazoles; Phenotype; Trypanocidal Agents; Trypanosoma cruzi | 1995 |
In vitro trypanocidal activity of tetraethylthiuram disulfide and sodium diethylamine-N-carbodithioate on Trypanosoma cruzi.
Topics: Animals; Disulfiram; Nitroimidazoles; Thiocarbamates; Trypanocidal Agents; Trypanosoma cruzi | 1996 |
Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cycloheximide; Glutathione; Nifurtimox; Nitroimidazoles; Species Specificity; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 1996 |
Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives.
Topics: Animals; Benzimidazoles; Enzyme Inhibitors; Imidazoles; Nitroimidazoles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 1996 |
Should benznidazole be used in chronic Chagas' disease?
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; Neoplasms; Nitroimidazoles; Trypanocidal Agents | 1997 |
Long-lasting antibodies detected by a trans-sialidase inhibition assay of sera from parasite-free, serologically cured chagasic patients.
Topics: Adult; Animals; Antibodies, Protozoan; Argentina; Brazil; Chagas Disease; Child; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Longitudinal Studies; Neuraminidase; Nitroimidazoles; Paraguay; Pregnancy; Pregnancy Complications, Parasitic; Reference Values; Time Factors; Trypanosoma cruzi | 1997 |
Effects of nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi.
Topics: Animals; Glutathione; Nifurtimox; Nitroimidazoles; Spermidine; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 1997 |
Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological study.
Topics: Acute Disease; Adolescent; Adult; Animals; Cardiomegaly; Chagas Cardiomyopathy; Child; Child, Preschool; Electrocardiography; Female; Humans; Infant; Male; Middle Aged; Myocardium; Nitroimidazoles; Pericardial Effusion; Trypanocidal Agents; Trypanosoma cruzi; Venezuela | 1997 |
Experimental benznidazole encephalopathy: I. Clinical-neurological alterations.
Topics: Animals; Ataxia; Brain Diseases; Cranial Nerves; Dogs; Dose-Response Relationship, Drug; Humans; Male; Motor Activity; Neurotoxins; Nitroimidazoles; Posture; Quadriplegia; Reflex; Reflex, Stretch; Trypanocidal Agents | 1997 |
Experimental benznidazole encephalopathy: II. Electroencephalographic and morphological alterations.
Topics: Animals; Brain; Brain Diseases; Cerebellum; Dogs; Electroencephalography; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Nitroimidazoles; Peripheral Nerves; Reference Values; Trypanocidal Agents | 1997 |
Heart transplantation as a treatment for patients with end-stage Chagas' heart disease.
Topics: Chagas Cardiomyopathy; Heart Transplantation; Humans; Nitroimidazoles; Secondary Prevention; Trypanocidal Agents | 1997 |
Phenotype of recombinant Trypanosoma cruzi which overexpress elongation factor 1-gamma: possible involvement of EF-1gamma GST-like domain in the resistance to clomipramine.
Topics: Animals; Clomipramine; DNA, Complementary; Drug Resistance; Glutathione Transferase; Nifurtimox; Nitroimidazoles; Peptide Elongation Factor 1; Peptide Elongation Factors; Phenotype; Trypanocidal Agents; Trypanosoma cruzi | 1997 |
In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole.
Topics: Animals; Chagas Disease; Drug Resistance; Male; Mice; Nitroimidazoles; Parasitemia; Parasitology; Phenotype; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Recipients and donors of bone marrow transplants suffering from Chagas' disease: management and preemptive therapy of parasitemia.
Topics: Adult; Bone Marrow Transplantation; Chagas Disease; Chronic Disease; Female; Humans; Immunosuppression Therapy; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Nitroimidazoles; Parasitemia; Recurrence; Transplantation, Autologous; Transplantation, Homologous; Trypanocidal Agents | 1998 |
Higher incidence of malignant neoplasms after heart transplantation for treatment of chronic Chagas' heart disease.
Topics: Adult; Carcinoma, Squamous Cell; Chagas Cardiomyopathy; Chemoprevention; Chronic Disease; Cocarcinogenesis; Cyclosporine; Female; Follow-Up Studies; Heart Failure; Heart Transplantation; Humans; Immunosuppressive Agents; Incidence; Lung Diseases; Lymphoproliferative Disorders; Male; Mutagens; Neoplasms; Neurilemmoma; Nitroimidazoles; Recurrence; Sarcoma, Kaposi; Skin Neoplasms; Survival Rate; Trypanocidal Agents | 1998 |
Trypanosoma cruzi: impact of clonal evolution of the parasite on its biological and medical properties.
Topics: Animals; Biological Evolution; Chagas Disease; Chlorocebus aethiops; Cluster Analysis; Discriminant Analysis; DNA, Protozoan; Electrophoresis, Cellulose Acetate; Genetic Variation; Genotype; Humans; Isoenzymes; Monte Carlo Method; Nifurtimox; Nitroimidazoles; Phylogeny; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1998 |
Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brazil; Chagas Disease; DNA, Protozoan; DNA, Ribosomal; Drug Resistance; Exons; Genes, Protozoan; Genetic Variation; Glucose-6-Phosphate Isomerase; Humans; Hypoxanthine Phosphoribosyltransferase; Isoenzymes; Nifurtimox; Nitroimidazoles; Polymorphism, Genetic; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Treatment of congenital Chagas' disease diagnosed and followed up by the polymerase chain reaction.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Immunoglobulin M; Incidence; Infant, Newborn; Infectious Disease Transmission, Vertical; Nitroimidazoles; Paraguay; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi.
Topics: Acute Disease; Animals; Chagas Disease; Drug Resistance; Interferon-gamma; Interleukin-12; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Polymerase Chain Reaction; Trypanocidal Agents | 1998 |
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.
Topics: Animals; Cells, Cultured; DNA Replication; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance; Gamma Rays; Muscle, Skeletal; Nifurtimox; Nitroimidazoles; Rats; Reproduction; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi; Uracil | 1998 |
Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Gene Expression; Genes, Protozoan; Gentian Violet; Nitroimidazoles; Phenotype; Superoxide Dismutase; Transformation, Genetic; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Effects of trifluralin on Trypanosoma cruzi in vitro and in vivo.
Topics: Animals; Cells, Cultured; Herbicides; In Vitro Techniques; Mice; Nitroimidazoles; Trifluralin; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
[Treatment of chronic Chagas' disease. Is the etiological treatment effective?].
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents | 1998 |
Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele.
Topics: Alleles; Amino Acid Sequence; Animals; Antimony; Base Sequence; DNA, Protozoan; Gene Deletion; Macrophages; Metals, Heavy; Molecular Sequence Data; Nifurtimox; Nitroimidazoles; Oligonucleotides, Antisense; Phenotype; Protozoan Proteins; Transcription, Genetic; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
Synthesis and antichagasic properties of new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides and related compounds.
Topics: Animals; Chlorocebus aethiops; Humans; Magnetic Resonance Spectroscopy; Nifurtimox; Nitroimidazoles; Spectrophotometry, Infrared; Thiadiazines; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 1999 |
Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages.
Topics: Animals; Cell Line; Chagas Disease; Cytokines; Down-Regulation; Gene Expression Regulation, Enzymologic; Immunosuppressive Agents; Interleukin-10; Interleukin-6; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroimidazoles; Transcriptional Activation; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 1999 |
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Female; Immunocompetence; Immunosuppression Therapy; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population.
Topics: Animals; Chagas Disease; Cytokines; Drug Resistance; Interleukin-12; Macrophages; Male; Mice; Nitric Oxide; Nitroimidazoles; Parasitemia; Phagocytosis; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 1999 |
Criteria of Chagas disease cure.
Topics: Adolescent; Adult; Animals; Antibodies, Protozoan; Chagas Disease; Humans; Middle Aged; Nitroimidazoles; Serologic Tests; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
Etiological treatment for infection by Trypanosoma cruzi.
Topics: AIDS-Related Opportunistic Infections; Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1999 |
Polarographic determination of benznidazole in DMSO.
Topics: Dimethyl Sulfoxide; Nitroimidazoles; Polarography; Solvents; Trypanocidal Agents | 1999 |
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
Topics: Acute Disease; Administration, Oral; Alkaloids; Animals; Benzylisoquinolines; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents | 2000 |
Congenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in north-western Argentina.
Topics: Adult; Animals; Argentina; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Hemagglutination Tests; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Middle Aged; Nifurtimox; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents | 2000 |
A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease.
Topics: Animals; Anti-Infective Agents; Antifungal Agents; Chagas Disease; Drug Combinations; Drug Synergism; Female; Ketoconazole; Mice; Nitroimidazoles; Ofloxacin; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.
Topics: Animals; Antigens, Protozoan; Cathepsin B; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Microbial; Flow Cytometry; Glycoproteins; Immunoblotting; Immunohistochemistry; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Cytotoxicity of prodigiosin and benznidazole on V79 cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Nitroimidazoles; Prodigiosin; Trypanocidal Agents | 2000 |
Enzymatic markers of heart lesion in mice infected with Trypanosoma cruzi and submitted to benznidazole chemotherapy.
Topics: Animals; Biomarkers; Chagas Disease; Creatine Kinase; Isoenzymes; Mice; Myocarditis; Myocardium; Nitroimidazoles; Trypanocidal Agents | 2000 |
Setting of a colorimetric method to determine the viability of Trypanosoma cruzi epimastigotes.
Topics: Animals; Colorimetry; Culture Media; Nifurtimox; Nitroimidazoles; Oxidation-Reduction; Parasitic Sensitivity Tests; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Reactivation of chronic Chagas' disease following allogeneic bone marrow transplantation and successful pre-emptive therapy with benznidazole.
Topics: Adult; Animals; Bone Marrow Transplantation; Chagas Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Nitroimidazoles; Postoperative Complications; Recurrence; Transplantation, Homologous; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
Chagas' disease.
Topics: Adolescent; Adult; Chagas Cardiomyopathy; Chagas Disease; Child; Chronic Disease; Humans; Nitroimidazoles; Risk Factors; Trypanocidal Agents | 2001 |
Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cells, Cultured; Chagas Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Heart; Interferon-gamma; Macrophages, Peritoneal; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Rats; Rats, Inbred Strains; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Benznidazole-induced ultrastructural and biochemical alterations in rat colon.
Topics: Animals; Colon; Intestinal Mucosa; Male; Nitroimidazoles; Nitroreductases; Rats; Rats, Sprague-Dawley; Trypanocidal Agents | 2000 |
Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kappaB activation.
Topics: Animals; Blotting, Western; Cells, Cultured; Depression, Chemical; Enzyme Induction; Genes, Reporter; I-kappa B Proteins; Interferon-gamma; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroimidazoles; Phosphorylation; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Transcription, Genetic; Transfection; Trypanocidal Agents; Ubiquitin | 2001 |
Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Chagas Disease; Drug Resistance; Gene Amplification; Glycoproteins; Humans; Karyotyping; Mice; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Polymorphism, Restriction Fragment Length; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Time-dependent oxidative stress caused by benznidazole.
Topics: Animals; Catalase; Glutathione; Glutathione Disulfide; Glutathione Reductase; Male; Nitroimidazoles; Oxidative Stress; Rats; Rats, Wistar; Time Factors; Trypanocidal Agents | 2001 |
Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.
Topics: Animals; Chagas Disease; Dogs; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Mice; Nitroimidazoles; Parasitemia; Parasitology; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.
Topics: Animals; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Phytotherapy; Plant Extracts; Quinolines; Rutaceae; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi.
Topics: Acute Disease; Animals; Chagas Disease; Disease Susceptibility; Immunoenzyme Techniques; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Necrosis; Nitroimidazoles; Parasitemia; Spleen; Survival Rate; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 2001 |
The restoring effect of trifluralin and benznidazole on the abnormal fatty-acid pattern induced by Trypanosoma cruzi in the liver microsomes of infected mice.
Topics: Animals; Chagas Disease; Cholesterol; Cholesterol Esters; Fatty Acids; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Nitroimidazoles; Trifluralin; Triglycerides; Trypanocidal Agents | 2002 |
Voltammetric behavior of benznidazole at a DNA-electrochemical biosensor.
Topics: Biosensing Techniques; Carbon; DNA Damage; DNA, Single-Stranded; Electrochemistry; Electrodes; Nitroimidazoles | 2002 |
Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure.
Topics: Animals; Antigens, CD; Chagas Disease; Female; Gene Deletion; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroimidazoles; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Resistance; Exudates and Transudates; Inflammation; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitroimidazoles; omega-N-Methylarginine; Phosphorylcholine; Survival Analysis; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2002 |
The dog as model for chemotherapy of the Chagas' disease.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Dogs; Drug Resistance; Female; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Development and in vitro characterisation of a benznidazole liposomal formulation.
Topics: Chemistry, Pharmaceutical; Liposomes; Nitroimidazoles; Technology, Pharmaceutical | 2002 |
Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Nitroimidazoles; Secondary Prevention; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes.
Topics: Animals; Chagas Disease; Female; Genotype; Itraconazole; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2003 |
Relationship between long-term resistance to Trypanosoma cruzi and latent infection, examined by antibody production and polymerase chain reaction in mice.
Topics: Animals; Animals, Newborn; Antibodies, Protozoan; Chagas Disease; DNA, Protozoan; Female; Immunization; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi; Vaccines, Attenuated; Virulence | 2002 |
Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain.
Topics: Animals; beta-Galactosidase; Chlorocebus aethiops; Cloning, Organism; Mice; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2002 |
Trypanocidal and leishmanicidal properties of substitution-containing chalcones.
Topics: Amphotericin B; Animals; Chalcone; Dose-Response Relationship, Drug; Leishmania braziliensis; Nitroimidazoles; Structure-Activity Relationship; Trypanosoma cruzi | 2003 |
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives.
Topics: Animals; Inhibitory Concentration 50; Nifurtimox; Nitroimidazoles; Polycyclic Compounds; Polycyclic Sesquiterpenes; Quinones; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
Synthesis and evaluation of a series of 1,4-diarylbutadienes for anticoccidial activity.
Topics: Animals; Antiprotozoal Agents; Butadienes; Cells, Cultured; Chickens; Coccidiosis; Drug Evaluation, Preclinical; Eimeria tenella; In Vitro Techniques; Nitroimidazoles; Poultry Diseases; Structure-Activity Relationship | 2003 |
[Interventional study in the natural evolution of Chagas disease. Evaluation of specific antiparasitic treatment. Retrospective-prospective study of antiparasitic therapy].
Topics: Adolescent; Adult; Aged; Allopurinol; Antiprotozoal Agents; Chagas Cardiomyopathy; Chagas Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Prospective Studies; Retrospective Studies; Time Factors; Treatment Outcome; Trypanocidal Agents | 2000 |
Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus.
Topics: Animals; Esophageal Diseases; Gastric Mucosa; Histocytochemistry; Male; Microscopy, Electron; Nitroimidazoles; Nitroreductases; Rats; Rats, Sprague-Dawley; Trypanocidal Agents | 2003 |
Enzyme-linked immunoassay using recombinant trans-sialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment.
Topics: Adult; Animals; Antibodies, Protozoan; Chagas Disease; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; Immunoblotting; Leishmaniasis; Neuraminidase; Nitroimidazoles; Recombinant Proteins; Sensitivity and Specificity; Treatment Outcome; Trypanocidal Agents | 2003 |
Trypanosoma cruzi: genetic group with peculiar biochemical and biological behavior.
Topics: Animals; Behavior, Animal; DNA, Protozoan; Genotype; Glycoconjugates; Humans; Minisatellite Repeats; Nitroimidazoles; Parasitic Sensitivity Tests; Polymerase Chain Reaction; Polymorphism, Genetic; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
Inhibition of Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II by N-isopropyl oxamate and its effect on intact epimastigotes.
Topics: Alcohol Oxidoreductases; Animals; Dose-Response Relationship, Drug; Kinetics; Models, Chemical; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Protein Isoforms; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
Liposomal benznidazole: a high-performance liquid chromatographic determination for biodistribution studies.
Topics: Chromatography, High Pressure Liquid; Kidney; Liposomes; Liver; Lung; Nitroimidazoles; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tissue Distribution | 2003 |
Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Cloning, Molecular; Female; Genotype; Heart; Inflammation; Itraconazole; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Trypanosoma cruzi; Urogenital System | 2004 |
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
Topics: Animals; Buthionine Sulfoximine; Electrophoresis, Polyacrylamide Gel; Glutathione; Metallothionein; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Spermidine; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Chagas seropositive donors in kidney transplantation.
Topics: Chagas Disease; Female; Follow-Up Studies; Humans; Kidney; Kidney Transplantation; Male; Nitroimidazoles; Time Factors; Tissue Donors; Trypanocidal Agents | 2004 |
Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough.
Topics: Animals; Chagas Disease; Female; Injections, Intravenous; Liposomes; Liver; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Particle Size; Phospholipids; Rats; Rats, Wistar; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts.
Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Monocytes; Nifurtimox; Nitroimidazoles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2004 |
Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chagas Disease; DNA Primers; Dose-Response Relationship, Drug; Endotoxemia; Flow Cytometry; Inflammation; Interleukin-10; Interleukin-12; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroimidazoles; Peritoneal Lavage; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 2004 |
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.
Topics: Animals; Buthionine Sulfoximine; Chlorocebus aethiops; Drug Synergism; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2005 |
A new pharmacological screening assay with Trypanosoma cruzi epimastigotes expressing beta-galactosidase.
Topics: Animals; beta-Galactosidase; Chlorophenols; Galactosides; Lac Operon; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Spectrophotometry; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Heart; Humans; Male; Mice; Mice, Inbred BALB C; Myocarditis; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
[Treatment of Chagas disease with benznidazole and thioctic acid].
Topics: Antioxidants; Chagas Disease; Drug Therapy, Combination; Humans; Nitroimidazoles; Thioctic Acid; Trypanocidal Agents | 2005 |
Benznidazole therapy in Trypanosoma cruzi-infected mice blocks thymic involution and apoptosis of CD4+CD8+ double-positive thymocytes.
Topics: Animals; Apoptosis; Atrophy; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Death; Chagas Disease; Flow Cytometry; Fluorescent Antibody Technique; Male; Mice; Microscopy, Confocal; Nitroimidazoles; Phenotype; Thymus Gland; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes.
Topics: Animals; Asteraceae; Lactones; Microscopy, Electron; Nitroimidazoles; Plant Extracts; Plant Leaves; Sesquiterpenes; Sesquiterpenes, Guaiane; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Chagas disease in bone marrow transplantation: an approach to preemptive therapy.
Topics: Adolescent; Adult; Aged; Bone Marrow Transplantation; Chagas Disease; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Middle Aged; Nitroimidazoles; Parasitemia; Retrospective Studies; Trypanocidal Agents | 2005 |
Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains.
Topics: Alcohol Oxidoreductases; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Mice; Models, Chemical; NAD; Nifurtimox; Nitroimidazoles; Oxamic Acid; Species Specificity; Time Factors; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 2005 |
Differential gene expression in benznidazole-resistant Trypanosoma cruzi parasites.
Topics: Animals; Drug Resistance; Electrophoresis; Enzymes; Gene Expression Profiling; Gene Expression Regulation; Humans; Molecular Sequence Data; Nitroimidazoles; Parasitic Sensitivity Tests; Polymerase Chain Reaction; Protozoan Proteins; Random Amplified Polymorphic DNA Technique; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Benznidazole vs benznidazole in multilamellar liposomes: how different they interact with blood components?
Topics: Animals; Blood Proteins; Drug Interactions; Humans; Lipoproteins; Liposomes; Nitroimidazoles; Permeability; Rats; Rats, Wistar; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans.
Topics: Aspergillus nidulans; Diploidy; Homozygote; Mitosis; Mutagenicity Tests; Mutagens; Nitroimidazoles | 2005 |
[Mechanisms responsible for myocardial damage progression in chronic Chagas' disease].
Topics: Allopurinol; Antimetabolites; Chagas Cardiomyopathy; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Electrocardiography; Follow-Up Studies; Humans; Nitroimidazoles; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Trypanocidal Agents | 2005 |
[Clinical predictors of chronic chagasic myocarditis progression].
Topics: Adult; Chagas Cardiomyopathy; Disease Progression; Echocardiography; Electrocardiography; Follow-Up Studies; Heart Failure; Humans; Middle Aged; Myocarditis; Nitroimidazoles; Prognosis; Proportional Hazards Models; Risk Factors; Time Factors; Trypanocidal Agents | 2005 |
The need of a neonatal preparation for Chagas disease.
Topics: Chagas Disease; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease Transmission, Vertical; Nifurtimox; Nitroimidazoles; Patient Compliance; Trypanocidal Agents | 2005 |
Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole.
Topics: Animals; Cell Line; Chemistry, Pharmaceutical; Dioctyl Sulfosuccinic Acid; Drug Stability; Ethanol; Nitroimidazoles; Parasitic Sensitivity Tests; Phthalic Acids; Polyethylene Glycols; Polysorbates; Solvents; Surface-Active Agents; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis.
Topics: Alkaloids; Animals; Chagas Disease; Chlorocebus aethiops; Diterpenes; Inhibitory Concentration 50; Nitroimidazoles; Parasitic Sensitivity Tests; Plant Preparations; Time Factors; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2006 |
Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.
Topics: Animals; Antifungal Agents; Blotting, Northern; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Gene Deletion; Gene Dosage; Gene Expression Profiling; Molecular Sequence Data; Molecular Weight; NADPH Dehydrogenase; Nifurtimox; Nitroimidazoles; Oligonucleotide Array Sequence Analysis; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Fungal; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology; Trypanosoma cruzi | 2006 |
Development of resazurin microtiter assay for drug sensibility testing of Trypanosoma cruzi epimastigotes.
Topics: Animals; Colorimetry; Humans; Indicators and Reagents; Nifurtimox; Nitroimidazoles; Oxazines; Oxidation-Reduction; Parasitic Sensitivity Tests; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi; Xanthenes | 2006 |
Detection of parasitemia profiles by blood culture after treatment of human chronic Trypanosoma cruzi infection.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antiparasitic Agents; Cell Culture Techniques; Female; Humans; Male; Middle Aged; Nitroimidazoles; Parasitemia; Trypanosoma cruzi; Trypanosomiasis | 2006 |
Chagas disease: hidden affliction and visible neglect.
Topics: Animals; Chagas Disease; Child; Diagnosis, Differential; Humans; Nifurtimox; Nitroimidazoles; Poverty; Risk Factors; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.
Topics: Acute Disease; Animals; B-Lymphocytes; Chagas Disease; Immunity, Cellular; Lymph Nodes; Lymphoid Tissue; Male; Mice; Nitroimidazoles; Parasitemia; Spleen; T-Lymphocytes; Thymus Gland; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Treatment of experimental chronic chagas disease with trifluralin.
Topics: Animals; Chagas Disease; Disease Models, Animal; Electrocardiography; Heart; Herbicides; Male; Mice; Mice, Inbred Strains; Myocarditis; Nitroimidazoles; Trifluralin; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Summaries for patients. Long-term outcomes of treating nonacute Chagas disease with benznidazole.
Topics: Adult; Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prognosis; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
The treatment of Chagas disease (South American trypanosomiasis).
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 2006 |
Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.
Topics: Alkaloids; Animals; Carbolines; Chagas Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Indole Alkaloids; Indoles; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Nitroimidazoles; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi; Zanthoxylum | 2007 |
Polymerase chain reaction detection and serologic follow-up after treatment with benznidazole in Bolivian children infected with a natural mixture of Trypanosoma cruzi I and II.
Topics: Animals; Antibodies, Protozoan; Bolivia; Child; Child, Preschool; Humans; Nitroimidazoles; Polymerase Chain Reaction; Species Specificity; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 2006 |
Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole.
Topics: Amino Acid Sequence; Animals; Chromosome Mapping; Drug Resistance; Gene Dosage; Humans; Molecular Sequence Data; Nitroimidazoles; Parasitic Sensitivity Tests; Sequence Analysis, DNA; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi; Up-Regulation | 2006 |
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Topics: Animals; Gene Deletion; Genes, Protozoan; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Superoxide Dismutase; Trypanosoma brucei brucei | 2007 |
Liver transplantation from deceased donors serologically positive for Chagas disease.
Topics: Adult; Antibodies, Protozoan; Cadaver; Chagas Disease; Female; Humans; Liver Transplantation; Male; Middle Aged; Nitroimidazoles; Tissue and Organ Procurement; Tissue Donors; Treatment Outcome; Trypanocidal Agents | 2007 |
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.
Topics: Animals; Chagas Disease; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Brazil; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Female; HIV Infections; Humans; Male; Meningoencephalitis; Middle Aged; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Xenodiagnosis | 2007 |
DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi.
Topics: Animals; Blood Cells; Chagas Disease; DNA Damage; Liver; Male; Mice; Mice, Inbred BALB C; Myocardium; Neoplasms; Nitric Oxide; Nitroimidazoles; Random Allocation; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Cerebral trypanosomiasis in an incarcerated man.
Topics: Adult; Animals; Biopsy, Needle; Central Nervous System Protozoal Infections; Craniotomy; Disease Progression; Fatal Outcome; Humans; Immunohistochemistry; Male; Manitoba; Nitroimidazoles; Prisoners; Tomography, X-Ray Computed; Trypanosoma; Trypanosomiasis | 2007 |
Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Mice; Nitroimidazoles; Thioridazine; Trypanocidal Agents | 2007 |
[Chest pain and peripheral eosinophilia].
Topics: Adult; Amiodarone; Chagas Cardiomyopathy; Chest Pain; Diuretics; Drug Therapy, Combination; Electrocardiography; Eosinophilia; Furosemide; Humans; Male; Nitroimidazoles; Radiography, Thoracic; Trypanocidal Agents; Vasodilator Agents | 2007 |
Modulation of autoimmunity by treatment of an infectious disease.
Topics: Animals; Autoimmune Diseases; Autoimmunity; Chagas Cardiomyopathy; Humans; Hypersensitivity, Delayed; Immunosuppressive Agents; Male; Mice; Myocarditis; Myosins; Nitroimidazoles; Treatment Outcome; Trypanosoma cruzi | 2007 |
Novel potential drug against T. cruzi and its interaction with surfactant micelles.
Topics: Animals; Chagas Disease; Erythrocytes; Hemolysis; Hydrazones; Micelles; Nitrofurans; Nitroimidazoles; Scattering, Small Angle; Sheep; Solubility; Surface-Active Agents; Trypanocidal Agents; Trypanosoma cruzi; X-Ray Diffraction | 2007 |
In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains.
Topics: Animals; Chagas Disease; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
[Genetic diversity and Trypanosoma cruzi clone resistance to treatment with benzonidazole].
Topics: Animals; Drug Resistance; Genetic Variation; Genotype; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Impact of dual infections on chemotherapeutic efficacy in BALB/c mice infected with major genotypes of Trypanosoma cruzi.
Topics: Acute Disease; Alleles; Animals; Chagas Disease; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Mice; Mice, Inbred BALB C; Microsatellite Repeats; Nitroimidazoles; Reverse Transcriptase Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Congenital Trypanosoma cruzi infection in a non-endemic area.
Topics: Adult; Animals; Chagas Disease; Child, Preschool; Female; Humans; Immunosuppressive Agents; Infectious Disease Transmission, Vertical; Male; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome | 2007 |
Trypanosoma cruzi: characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations.
Topics: Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Cloning, Molecular; DNA, Protozoan; Drug Resistance; Electrophoresis, Gel, Pulsed-Field; Gene Expression Regulation, Enzymologic; Nitroimidazoles; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Protozoan; Transcription, Genetic; Trypanocidal Agents; Trypanosoma cruzi; Tyrosine Transaminase | 2008 |
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Topics: Animals; Cattle; Cells, Cultured; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Homeodomain Proteins; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Severe invalidating pain syndrome associated with benznidazole therapy for Chagas' disease.
Topics: Adult; Arthralgia; Chagas Disease; Female; Humans; Nitroimidazoles; Somatoform Disorders; Trypanocidal Agents | 2008 |
Mexican Trypanosoma cruzi isolates: in vitro susceptibility of epimastigotes to anti-trypanosoma cruzi drugs and metacyclic forms to complement-mediated lysis.
Topics: Animals; Antibodies, Protozoan; Complement System Proteins; Drug Resistance; Gentian Violet; Geography; Humans; Life Cycle Stages; Mexico; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole.
Topics: Animals; Chagas Disease; Cyclophosphamide; Dogs; Drug Resistance; Female; Humans; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Serial Passage; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern.
Topics: Adolescent; Antigens, CD; Antiprotozoal Agents; B-Lymphocytes; Biomarkers; Chagas Disease; Child; Cytokines; Flow Cytometry; Humans; Killer Cells, Natural; Longitudinal Studies; Lymphocyte Activation; Monocytes; Nitroimidazoles; T-Lymphocytes | 2008 |
Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes.
Topics: Animal Structures; Animals; Antibodies, Protozoan; Blood; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred BALB C; Nitroimidazoles; Polymerase Chain Reaction; Serologic Tests; Treatment Outcome; Trypanosoma cruzi | 2008 |
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Topics: Animals; Drug Resistance; Gene Expression Regulation; Genome, Protozoan; Mitochondria; Nifurtimox; Nitroimidazoles; Nitroreductases; Phenotype; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Chagas disease, France.
Topics: Adult; Animals; Chagas Disease; Female; France; French Guiana; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
Topics: Animals; Bromodeoxyuridine; CD8-Positive T-Lymphocytes; Chagas Disease; Immunologic Memory; Immunophenotyping; Mice; Nitroimidazoles; Receptors, Chemokine; Treatment Outcome; Trypanosoma cruzi | 2008 |
Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole.
Topics: Animals; Cyclophilin A; Cysteine Endopeptidases; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Glutamate Dehydrogenase; Hydroxyprostaglandin Dehydrogenases; Nitroimidazoles; Nucleoside-Diphosphate Kinase; Peptide Hydrolases; Peroxiredoxins; Proteome; Protozoan Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tandem Mass Spectrometry; Trypanocidal Agents; Trypanosoma cruzi; Tyrosine Transaminase | 2008 |
Changes of RAPD profile of Trypanosoma cruzi II with Canova and Benznidazole.
Topics: Animals; Chagas Disease; Crotalid Venoms; DNA, Protozoan; Materia Medica; Mice; Nitroimidazoles; Plant Extracts; Random Amplified Polymorphic DNA Technique; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Acute chagasic myocardiopathy after orthotopic liver transplantation with donor and recipient serologically negative for Trypanosoma cruzi: a case report.
Topics: Adult; Animals; Chagas Cardiomyopathy; Echocardiography; Fatal Outcome; Heart; Humans; Liver Transplantation; Male; Nitroimidazoles; Pancreas Transplantation; Postoperative Complications; Trypanocidal Agents; Trypanosoma cruzi; Ventricular Dysfunction, Left | 2008 |
Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
Topics: Animals; Antimalarials; Blotting, Northern; DNA, Protozoan; Drug Resistance; Gene Expression Profiling; Genes, Protozoan; Molecular Sequence Data; Nitroimidazoles; Protozoan Proteins; RNA, Messenger; RNA, Protozoan; Sequence Analysis, DNA; Trypanosoma cruzi | 2008 |
Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.
Topics: Animals; Carboxylic Acids; Electrochemistry; Models, Molecular; Molecular Conformation; Nitroimidazoles; Static Electricity; Stereoisomerism; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole.
Topics: Animals; Chagas Disease; DNA, Protozoan; Female; Genotype; Mice; Mice, Inbred BALB C; Nitroimidazoles; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Complexation of the anti-Trypanosoma cruzi drug benznidazole improves solubility and efficacy.
Topics: Animals; Chagas Disease; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Nitroimidazoles; Spectrophotometry, Ultraviolet; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.
Topics: Analysis of Variance; Animals; Chagas Disease; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Hemoglobins; Iron; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Siderophores; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Strategy to assess the overall cytokine profile of circulating leukocytes and its association with distinct clinical forms of human Chagas disease.
Topics: Adult; Aged; Animals; Antigens, Protozoan; B-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Chi-Square Distribution; Cohort Studies; Cytokines; Female; Flow Cytometry; Humans; Immunophenotyping; Leukocytes, Mononuclear; Male; Middle Aged; Nitroimidazoles; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.
Topics: Animals; Chagas Disease; Cyclophosphamide; Dogs; Drug Resistance; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Trypanosoma cruzi: Genetic diversity influences the profile of immunoglobulins during experimental infection.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Female; Genetic Variation; Genotype; Immunoglobulin G; Mice; Nitroimidazoles; Phylogeny; Random Allocation; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Development of novel formulations for Chagas' disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks.
Topics: Administration, Oral; Chagas Disease; Chitosan; Drug Carriers; Drug Compounding; Drug Design; Humans; Microscopy, Electron, Scanning; Molecular Structure; Neural Networks, Computer; Nitroimidazoles; Particle Size; Solubility; Surface Properties; Trypanocidal Agents | 2009 |
[Part VI. Antiparasitic treatment for Chagas disease].
Topics: Allopurinol; Animals; Chagas Disease; Follow-Up Studies; Humans; Immunocompromised Host; Immunosuppressive Agents; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects.
Topics: Animals; Biotransformation; Drug Evaluation, Preclinical; Heart; Male; Microscopy, Electron, Transmission; Microsomes; Myocardium; Nifurtimox; Nitroimidazoles; Nitroreductases; Rats; Rats, Sprague-Dawley; Time Factors; Trypanocidal Agents | 2008 |
Trypanosoma cruzi: Biological characterization of lineages I and II supports the predominance of lineage I in Colombia.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Colombia; Host-Parasite Interactions; Insect Vectors; Nitroimidazoles; Panstrongylus; Polymerase Chain Reaction; Rhodnius; Triatoma; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2009 |
Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture.
Topics: Animals; Bacteremia; Chagas Disease; Enzyme-Linked Immunosorbent Assay; Inflammation; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Tumor Necrosis Factor-alpha | 2008 |
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.
Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Mice, Knockout; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
Topics: Animals; Blotting, Western; Computational Biology; Cytosol; Drug Resistance; Electrophoresis, Gel, Pulsed-Field; Humans; Mitochondria; Nitroimidazoles; Parasitic Sensitivity Tests; Peroxidases; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi; Up-Regulation | 2009 |
Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chagas Disease; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Nitroimidazoles; Quinolones; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Tumour-like chagasic encephalitis in AIDS patients: an atypical presentation in one of them and outcome in a small series of cases.
Topics: Adult; AIDS-Related Opportunistic Infections; Chagas Disease; Encephalitis; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitroimidazoles; Tomography, X-Ray Computed; Treatment Outcome; Trypanocidal Agents | 2008 |
[Chagas disease].
Topics: Animals; Chagas Disease; Emigration and Immigration; Humans; Insect Vectors; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Post-transplant lymphoproliferative disease presenting as a mass in the left ventricle in a heart transplant recipient at long-term follow-up.
Topics: Chagas Cardiomyopathy; Electrocardiography; Fatal Outcome; Follow-Up Studies; Heart Neoplasms; Heart Transplantation; Heart Ventricles; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nitroimidazoles; Postoperative Complications; Recurrence; Time Factors; Ultrasonography | 2009 |
Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles.
Topics: Animals; Antiprotozoal Agents; Cell Line; Computational Biology; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Entamoeba histolytica; Giardia lamblia; Imidazoles; Nitroimidazoles; Trichomonas vaginalis | 2009 |
In vitro trypanocidal activity of phenolic derivatives from Peperomia obtusifolia.
Topics: Animals; Chromans; Life Cycle Stages; Macrophages; Mice; Molecular Structure; Nitroimidazoles; Peperomia; Phenols; Plant Extracts; Plant Leaves; Plant Stems; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up.
Topics: Adult; Animals; Case-Control Studies; Chagas Disease; Chronic Disease; Cohort Studies; DNA, Kinetoplast; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Male; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
Novel cytostatic activity of the trypanocidal drug Benznidazole.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Cytostatic Agents; Dogs; HeLa Cells; Humans; Leupeptins; Mice; NF-kappa B; Nitric Oxide; Nitriles; Nitroimidazoles; Sulfones; Trypanocidal Agents | 2009 |
Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents.
Topics: Animals; Hydroxybenzoates; Models, Molecular; Nitrofurans; Nitroimidazoles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole.
Topics: Adult; Aged; Brazil; Chagas Disease; Disease Outbreaks; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Time Factors; Trypanocidal Agents; Urban Population; Young Adult | 2009 |
Reduction of parasite levels in blood improves pregnancy outcome during experimental Trypanosoma cruzi infection.
Topics: Animals; Antibodies, Protozoan; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; Chagas Disease; Female; Gene Expression Regulation; Hyaluronan Receptors; Immunoglobulin G; Interferon-gamma; Lectins, C-Type; Mice; Nitroimidazoles; Parasitemia; Placenta; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Spleen; Time Factors; Trypanosoma cruzi | 2009 |
Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi.
Topics: Alcohol Dehydrogenase; Animals; Blotting, Northern; DNA, Protozoan; Drug Resistance; Humans; Immunoblotting; Mice; Molecular Weight; Nifurtimox; Nitroimidazoles; Phylogeny; Protozoan Proteins; RNA, Messenger; RNA, Protozoan; Sequence Analysis, DNA; Sequence Homology; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Chagas disease: the forgotten American neuroinfection.
Topics: Americas; Central Nervous System Diseases; Chagas Disease; History, 20th Century; History, 21st Century; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2009 |
Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières.
Topics: Adolescent; Animals; Bolivia; Chagas Disease; Child; Child, Preschool; Developing Countries; Education; Female; Follow-Up Studies; Guatemala; Honduras; Humans; Infant; Insect Control; Male; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Antioxidant therapy attenuates oxidative insult caused by benzonidazole in chronic Chagas' heart disease.
Topics: Antioxidants; Ascorbic Acid; Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Vitamin E | 2010 |
Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery.
Topics: Adolescent; Animals; Chagas Disease; DNA, Protozoan; Female; Humans; Infant, Newborn; Molecular Sequence Data; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Sequence Analysis, DNA; Triplets; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Chagas' disease and its toll on the heart.
Topics: Acute Disease; Arrhythmias, Cardiac; Brazil; Chagas Cardiomyopathy; Chronic Disease; Defibrillators, Implantable; Heart Failure; History, 20th Century; Humans; Nitroimidazoles; Nobel Prize; Trypanocidal Agents | 2009 |
Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole.
Topics: Animals; Aspirin; Cell Line; Cell Survival; Cyclooxygenase Inhibitors; Drug Synergism; Inhibitory Concentration 50; Macrophages; Mice; Nifurtimox; Nitric Oxide; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Trypanosoma cruzi: Immunological predictors of benznidazole efficacy during experimental infection.
Topics: Animals; Antibodies, Protozoan; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Hyaluronan Receptors; Immunoglobulin G; Immunophenotyping; Lectins, C-Type; Male; Mice; Mice, Inbred C3H; Muscle, Skeletal; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Spleen; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease.
Topics: Animals; Chagas Cardiomyopathy; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Evidence-Based Medicine; Humans; Nitroimidazoles; Patient Selection; Pilot Projects; Trypanocidal Agents | 2009 |
Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.
Topics: Animals; Chagas Disease; Cyclophosphamide; Female; Genetic Variation; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Secondary Prevention; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
New advances in the management of a long-neglected disease.
Topics: Adult; Animals; Bolivia; CD8-Positive T-Lymphocytes; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Interferon-gamma; Interleukin-2; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Pregnancy; T-Lymphocytes; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies.
Topics: Chagas Disease; Crystallography, X-Ray; DNA, Protozoan; HeLa Cells; Humans; Indazoles; Nitroimidazoles; Oxidation-Reduction; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
The effect of the Rochagan on radiolabeling with (99m)Tc.
Topics: Animals; Erythrocytes; Humans; Nitroimidazoles; Plasma; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Technetium; Tin Compounds; Trypanocidal Agents | 2009 |
Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras.
Topics: Age Distribution; Animals; Antibodies, Protozoan; Chagas Disease; Child; Child, Preschool; Chronic Disease; Epidemiologic Methods; Female; Honduras; Humans; Immunoglobulin G; Infant; Insect Control; Male; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Trypanosoma cruzi: parasite antigens sequestered in heart interstitial dendritic cells are related to persisting myocarditis in benznidazole-treated mice.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Chagas Cardiomyopathy; Dendritic Cells; Disease Models, Animal; Drug Resistance; Mice; Myocarditis; Myocardium; Nitroimidazoles; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Drug Resistance; Drug Synergism; Female; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroimidazoles; Organometallic Compounds; Parasitemia; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
[Chagas disease and immunodeficiency: HIV infection and transplantation].
Topics: Anti-HIV Agents; Chagas Disease; France; HIV Infections; Humans; Meningoencephalitis; Nifurtimox; Nitroimidazoles; Transplantation; Trypanocidal Agents | 2009 |
Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment.
Topics: Adolescent; Adult; Antibodies, Protozoan; Brazil; Chagas Cardiomyopathy; Chagas Disease; Child; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Male; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2009 |
Metabolization of nifurtimox and benznidazole in cellular fractions of rat mammary tissue.
Topics: Allopurinol; Animals; Cell Fractionation; Chromatography, High Pressure Liquid; Female; Lipid Peroxidation; Mammary Glands, Animal; Microscopy, Electron, Transmission; Microsomes; Nifurtimox; Nitroimidazoles; Nitroreductases; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Trypanocidal Agents | 2010 |
Effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole treatments during acute infection of two different Trypanosoma cruzi strains.
Topics: Acute Disease; Animals; Chagas Disease; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Interferon-gamma; Interleukin-2; Macrophages, Peritoneal; Male; Nitrites; Nitroimidazoles; Parasitemia; Rats; Rats, Wistar; Species Specificity; Survival Rate; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
[Chagas disease--varying treatment outcome].
Topics: Central America; Chagas Disease; Global Health; Humans; Nitroimidazoles; South America; Treatment Outcome; Trypanocidal Agents | 2010 |
New drugs for neglected infectious diseases: Chagas' disease.
Topics: Animals; Chagas Disease; Humans; Nifurtimox; Nitric Oxide Donors; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Canova medication modifies parasitological parameters in mice infected with Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Crotalid Venoms; Drug Therapy, Combination; Formularies, Homeopathic as Topic; Heart; Host-Pathogen Interactions; Intestines; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Plant Extracts; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.
Topics: Antiprotozoal Agents; Colombia; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Phosphorylcholine; Trypanosoma cruzi | 2009 |
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi | 2010 |
Acute Chagas' disease in postrenal transplant and treatment with benzonidazole.
Topics: Acute Disease; Adult; Chagas Disease; Fatal Outcome; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Male; Nitroimidazoles; Postoperative Complications; Renal Insufficiency; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
In vitro and in vivo trypanocidal effects of the cyclopalladated compound 7a, a drug candidate for treatment of Chagas' disease.
Topics: Animals; Cell Line; Chagas Disease; Female; Humans; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Palladium; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Trypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs.
Topics: Allopurinol; Animals; Cell Line; Cells, Cultured; Chagas Disease; Endemic Diseases; Inhibitory Concentration 50; Insect Vectors; Mice; Mice, Inbred C3H; Muscle Cells; Muscles; Nicaragua; Nitroimidazoles; Phylogeny; Rats; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.
Topics: Analysis of Variance; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclic N-Oxides; Disease Models, Animal; Disease Progression; Heart Function Tests; Hemodynamics; Lipid Peroxidation; Mitochondria, Heart; Nitroimidazoles; Oxidative Stress; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Trypanosoma cruzi | 2010 |
Usefulness of PCR for monitoring benznidazole response in patients with chronic Chagas' disease: a prospective study in a non-disease-endemic country.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chagas Disease; Child; Child, Preschool; Drug Monitoring; Follow-Up Studies; Humans; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2010 |
Heart rate variability in chronic Chagas patients before and after treatment with benznidazole.
Topics: Adult; Aged; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Chagas Disease; Chronic Disease; Drug Administration Schedule; Female; Heart Rate; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2010 |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
Topics: Acute Disease; Adolescent; Adult; Brazil; Chagas Disease; Child; Disease Outbreaks; Echocardiography, Doppler; Electrocardiography; Female; Humans; Male; Nitroimidazoles; Radiography, Thoracic; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Hydroxymethylnitrofurazone is active in a murine model of Chagas' disease.
Topics: Animals; Chagas Disease; Female; Liver; Mice; Molecular Structure; Muscle, Skeletal; Nitrofurazone; Nitroimidazoles; Polymerase Chain Reaction; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Chagas disease: pushing through the pipeline.
Topics: Adult; Animals; Chagas Disease; Child; Chronic Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Molecular Targeted Therapy; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2010 |
Chagas disease 101.
Topics: Acute Disease; Animals; Carrier State; Chagas Disease; Chronic Disease; Clinical Trials as Topic; History, 16th Century; History, 19th Century; History, 20th Century; History, 21st Century; History, Ancient; Humans; Insect Vectors; Latin America; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Benznidazole blocks NF-kappaB activation but not AP-1 through inhibition of IKK.
Topics: Animals; Enzyme Activation; I-kappa B Kinase; I-kappa B Proteins; Macrophage Activation; Macrophages; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitroimidazoles; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; Transcription Factor AP-1 | 2010 |
Antitrypanosomal agents: treatment or threat?
Topics: Chagas Cardiomyopathy; Chagas Disease; Clinical Trials as Topic; Drug Administration Schedule; Drug Eruptions; Humans; Meta-Analysis as Topic; Nifurtimox; Nitroimidazoles; Polyneuropathies; Trypanocidal Agents; Trypanosoma cruzi; United States | 2010 |
A preformulation study of a new medicine for Chagas disease treatment: physicochemical characterization, thermal stability, and compatibility of benznidazole.
Topics: Chagas Disease; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Excipients; Hot Temperature; Humans; Nitroimidazoles; Transition Temperature | 2010 |
Congenital infections with Trypanosoma cruzi or Toxoplasma gondii are associated with decreased serum concentrations of interferon-γ and interleukin-18 but increased concentrations of interleukin-10.
Topics: Chagas Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant; Infant, Newborn; Interferon-gamma; Interleukin-10; Interleukin-18; Male; Nifurtimox; Nitroimidazoles; Toxoplasmosis, Congenital; Trypanocidal Agents | 2010 |
[Human immunodeficiency virus and Chagas disease coinfection treated successfully with benznidazole and a raltegravir-based antiretroviral regimen: a case report].
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Chagas Disease; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Nitroimidazoles; Oligopeptides; Organophosphonates; Paraguay; Pyridines; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Spain; Tenofovir; Trypanocidal Agents; Zidovudine | 2011 |
Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.
Topics: Cell Culture Techniques; Drug Synergism; Herb-Drug Interactions; Inhibitory Concentration 50; Nitroimidazoles; Plant Leaves; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Chagas disease in Latin American migrants: a Spanish challenge.
Topics: Adult; Antiprotozoal Agents; Chagas Disease; Echocardiography; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Latin America; Male; Mass Screening; Nitroimidazoles; Polymerase Chain Reaction; Pregnancy; Prospective Studies; Spain; Transients and Migrants | 2011 |
A high-performance liquid chromatographic method for benznidazole quantitation in plasma of patients with Chagas disease.
Topics: Adult; Chagas Disease; Chromatography, High Pressure Liquid; Female; Humans; Male; Nitroimidazoles; Reproducibility of Results; Trypanocidal Agents | 2011 |
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Topics: Amino Acid Transport Systems; Drug Resistance; Eflornithine; Gene Knockdown Techniques; Genes, Protozoan; Genome-Wide Association Study; Humans; Nifurtimox; Nitroimidazoles; Nitroreductases; RNA Interference; Trypanosoma brucei brucei | 2011 |
Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease.
Topics: Adult; Chagas Disease; Drug Resistance; Female; Humans; Lethal Dose 50; Male; Microsatellite Repeats; Middle Aged; Nitroimidazoles; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Adverse events after the use of benznidazole in infants and children with Chagas disease.
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitroimidazoles; Prospective Studies; Trypanocidal Agents; Young Adult | 2011 |
Benznidazole treatment attenuates liver NF-κB activity and MAPK in a cecal ligation and puncture model of sepsis.
Topics: Animals; Cecum; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Exudates and Transudates; Gene Expression Regulation; Leukocyte Count; Ligation; Liver; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; p38 Mitogen-Activated Protein Kinases; Punctures; RNA, Messenger; Sepsis; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.
Topics: Animals; Chagas Disease; Chemical Precipitation; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Excipients; Female; Hardness Tests; Hypromellose Derivatives; Methylcellulose; Mice; Nitroimidazoles; Polymers; Solubility; Solvents; Tablets; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic Chagas disease: its relationship with treatment against parasites and myocardial damage.
Topics: Animals; Antibodies, Protozoan; Cardiomyopathies; Chagas Disease; Chronic Disease; Female; Humans; Immunity, Humoral; Male; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Ribosomal Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
The use of solid dispersion systems in hydrophilic carriers to increase benzonidazole solubility.
Topics: Calorimetry, Differential Scanning; Drug Carriers; Drug Compounding; Drug Stability; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning; Models, Molecular; Molecular Structure; Nitroimidazoles; Polyethylene Glycols; Povidone; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Trypanocidal Agents; X-Ray Diffraction | 2011 |
In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2011 |
[Benzonidazole: one of the rare treatment for Chagas disease].
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents | 2011 |
Development of effervescent tablets containing benzonidazole complexed with cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Biological Availability; Chagas Disease; Hydrophobic and Hydrophilic Interactions; Nitroimidazoles; Solubility; Tablets; Technology, Pharmaceutical; Water | 2011 |
Benzonidazole levels in blood vary with age in rats.
Topics: Age Factors; Animals; Chromatography, High Pressure Liquid; Microsomes, Liver; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Trypanocidal Agents | 2011 |
Short-term follow-up of chagasic patients after benzonidazole treatment using multiple serological markers.
Topics: Adolescent; Adult; Aged; Antibodies, Protozoan; Antigens, Protozoan; Antiprotozoal Agents; Biomarkers; Chagas Disease; Drug Monitoring; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Recombinant Proteins; Treatment Outcome; Young Adult | 2011 |
Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.
Topics: Amidines; Animals; Antifungal Agents; Benzamidines; Chagas Disease; Drug Combinations; Furans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Hypercoagulability biomarkers in Trypanosoma cruzi -infected patients.
Topics: Adult; Biomarkers; Biomarkers, Pharmacological; Chagas Disease; Chronic Disease; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prothrombin; Risk; Thrombin; Thromboembolism; Thrombophilia; Trypanosoma cruzi | 2011 |
Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi.
Topics: Chagas Disease; Drug Resistance; Gene Expression; Humans; Multigene Family; Nitroimidazoles; Nitroreductases; Protozoan Proteins; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro.
Topics: Amides; Animals; Cell Survival; Cells, Cultured; Chagas Disease; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease.
Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; Argentina; Chagas Disease; Chronic Disease; Drug Monitoring; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Trypanosoma cruzi | 2011 |
Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country.
Topics: Adult; Arthritis; Chagas Disease; Cohort Studies; Drug Eruptions; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Spain; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Different forms of administration of biotherapy 7dH in mice experimentally infected by Trypanosoma cruzi produce different effects.
Topics: Animals; Chagas Disease; Disease Models, Animal; Homeopathy; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
In vitro and in vivo trypanocidal synergistic activity of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide associated with benznidazole.
Topics: Amphotericin B; Animals; Body Weight; Carbolines; Cell Count; Cell Line; Chagas Disease; Drug Combinations; Drug Resistance; Drug Synergism; Haplorhini; Heart; Humans; Ketoconazole; Life Cycle Stages; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.
Topics: Biotransformation; Chagas Disease; Chromatography, Liquid; DNA Damage; Glyoxal; Guanosine; Humans; Hydroxylamine; Imidazoles; Kinetics; Mass Spectrometry; NAD; Nitroimidazoles; Nitroreductases; Prodrugs; Protozoan Proteins; Spectrophotometry; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2012 |
Benzonidazole therapy modulates interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children.
Topics: Adolescent; Autoantibodies; Case-Control Studies; Chagas Disease; Child; Female; Humans; Interferon-gamma; Male; Nitroimidazoles; Receptor, Muscarinic M2; Treatment Outcome; Trypanosoma cruzi | 2011 |
Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Topics: Animals; Biomarkers; Blood Proteins; Cardiac Myosins; Chagas Disease; Cyclic N-Oxides; Free Radical Scavengers; Gelsolin; Myosin Light Chains; Nitroimidazoles; Protein Carbonylation; Proteome; Rats; Rats, Sprague-Dawley; Trypanocidal Agents; Trypanosoma cruzi; Vimentin | 2012 |
Serological profiles and evaluation of parasitaemia by PCR and blood culture in individuals chronically infected by Trypanosoma cruzi treated with benzonidazole.
Topics: Adult; Age Factors; Antibodies, Protozoan; Chagas Disease; Chronic Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Male; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Retrospective Studies; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2012 |
Stone heart or apical retraction and calcification in Chagas' cardiomyopathy.
Topics: Adult; Barium Sulfate; Chagas Cardiomyopathy; Contrast Media; Coronary Angiography; Diagnosis, Differential; Echocardiography, Transesophageal; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Humans; Magnetic Resonance Imaging; Male; Nitroimidazoles; Polymerase Chain Reaction; Radiography, Thoracic; Trypanocidal Agents | 2012 |
Safety of benznidazole use in the treatment of chronic Chagas' disease.
Topics: Adolescent; Adult; Aged; Algorithms; Antiprotozoal Agents; Chagas Disease; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Models, Statistical; Nitroimidazoles; Young Adult | 2012 |
Supply chain problems for Chagas disease treatment.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 2012 |
Taiwaniaquinoid and abietane quinone derivatives with trypanocidal activity against T. cruzi and Leishmania spp.
Topics: Abietanes; Animals; Cell Line; Chagas Disease; Female; Fluorenes; Leishmania braziliensis; Leishmania infantum; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Quinones; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Erythrocytes; Humans; Inhibitory Concentration 50; Macrophages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Preclinical monitoring of drug association in experimental chemotherapy of Chagas' disease by a new HPLC-UV method.
Topics: Animals; Chagas Disease; Chromatography, High Pressure Liquid; Female; Itraconazole; Mice; Nitroimidazoles; Trypanocidal Agents | 2012 |
Nifurtimox chemotherapy: collateral effects in treated Trypanosoma cruzi infected patients.
Topics: Chagas Disease; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.
Topics: Alleles; Amino Acid Sequence; Animals; Chlorocebus aethiops; Cloning, Molecular; Drug Resistance; Gene Expression Regulation; Genetic Variation; Molecular Sequence Data; Mutation; Nitroimidazoles; Nitroreductases; Protozoan Proteins; Rats; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2012 |
Cardiomyopathy prognosis after benznidazole treatment in chronic canine Chagas' disease.
Topics: Animal Experimentation; Animals; Antiprotozoal Agents; Chagas Cardiomyopathy; Chronic Disease; DNA, Protozoan; Dog Diseases; Dogs; Heart; Nitroimidazoles; Parasitemia; Prognosis; Trypanosoma cruzi | 2012 |
Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease.
Topics: Adult; Antigens, CD; Antigens, Protozoan; CD4-Positive T-Lymphocytes; Chagas Disease; Chronic Disease; CTLA-4 Antigen; Gene Expression Regulation; Heart; Humans; Interferon-gamma; Leukocyte Immunoglobulin-like Receptor B1; Male; Middle Aged; Myocarditis; Nitroimidazoles; Receptors, Immunologic; Species Specificity; Trypanosoma cruzi | 2012 |
[A clinical and epidemiological study of the Trypanosoma cruzi infected population in the north metropolitan area of Barcelona].
Topics: Adult; Asymptomatic Infections; Chagas Cardiomyopathy; Chagas Disease; Emigrants and Immigrants; Female; Humans; Incidence; Male; Nitroimidazoles; Prospective Studies; Spain; Trypanocidal Agents | 2012 |
Blood leukocytes from benznidazole-treated indeterminate chagas disease patients display an overall type-1-modulated cytokine profile upon short-term in vitro stimulation with Trypanosoma cruzi antigens.
Topics: Adolescent; Adult; Antiprotozoal Agents; CD8-Positive T-Lymphocytes; Chagas Disease; Cross-Sectional Studies; Cytokines; Female; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Male; Middle Aged; Nitroimidazoles; Th1 Cells; Trypanosoma cruzi; Young Adult | 2012 |
The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide.
Topics: Ascorbate Peroxidases; Blotting, Western; DNA, Protozoan; Drug Resistance; Electrophoresis, Gel, Pulsed-Field; Hydrogen Peroxide; Molecular Sequence Data; Nitroimidazoles; Phylogeny; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Nuclease activity and ultrastructural effects of new sulfonamides with anti-leishmanial and trypanocidal activities.
Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Deoxyribonucleases; Leishmania infantum; Macrophages; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Molecular Structure; Nitroimidazoles; Phosphorylcholine; Sulfonamides | 2012 |
Reactivation of Chagas' disease: cutaneous manifestations in two immunosuppressed patients.
Topics: Adult; Bone Marrow Transplantation; Chagas Disease; Female; Heart Transplantation; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Recurrence; Trypanocidal Agents | 2012 |
Posttherapeutic cure criteria in Chagas' disease: conventional serology followed by supplementary serological, parasitological, and molecular tests.
Topics: Adolescent; Adult; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Drug Monitoring; Female; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Nitroimidazoles; Parasitology; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi; Young Adult | 2012 |
Congenital transmission of Chagas disease - Virginia, 2010.
Topics: Adult; Ascites; Bolivia; Chagas Disease; Female; Humans; Infant, Newborn; Male; Nitroimidazoles; Pericardial Effusion; Pleural Effusion; Pregnancy; Pregnancy Complications, Infectious; Serologic Tests; Trypanocidal Agents; Virginia | 2012 |
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
In vitro and in vivo studies of the trypanocidal activity of four terpenoid derivatives against Trypanosoma cruzi.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Chlorocebus aethiops; Female; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Parasite Load; Parasitic Sensitivity Tests; Plant Extracts; Terpenes; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2012 |
Reactivation of Chagas disease by immunosuppressive therapy in a patient with systemic lupus erythematosus: report of an exceptional case.
Topics: Adult; Azathioprine; Biopsy; Chagas Disease; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Nitroimidazoles; Skin; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain.
Topics: Chagas Disease; Developed Countries; Humans; Nitroimidazoles; Spain; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.
Topics: Animals; Antidepressive Agents, Second-Generation; Chagas Disease; Depression; Emotions; Exploratory Behavior; Female; Fluoxetine; Glial Fibrillary Acidic Protein; Hindlimb Suspension; Immunohistochemistry; Meningoencephalitis; Mice; Mice, Inbred C3H; Motor Activity; Nitroimidazoles; Pentoxifylline; Phenotype; Phosphodiesterase Inhibitors; Psychomotor Performance; Real-Time Polymerase Chain Reaction; Swimming; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2012 |
Congenital Chagas disease reported in United States.
Topics: Chagas Disease; Female; Humans; Infant, Newborn; Male; Mass Screening; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Trypanocidal Agents; Trypanosoma cruzi; United States | 2012 |
Antiparasitic Effect of Vitamin B12 on Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Female; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Vitamin B 12 | 2012 |
Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi.
Topics: Animals; DNA, Protozoan; Drug Resistance; Gene Expression Regulation; Genome, Protozoan; Monosaccharide Transport Proteins; Nitroimidazoles; Phylogeny; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites.
Topics: Animals; Cardiomyopathies; Chagas Disease; Genotype; Heart; Inflammation; Mexico; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.
Topics: Adult; Chagas Disease; Chronic Disease; Drug Administration Schedule; Female; Humans; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
Topics: Benzoquinones; Escherichia coli; Kinetics; Mitochondria; Molecular Targeted Therapy; NAD; Nifurtimox; Nitroimidazoles; Nitroreductases; Prodrugs; Protozoan Proteins; Recombinant Proteins; Small Molecule Libraries; Structure-Activity Relationship; Substrate Specificity; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2012 |
Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Mice; Nitroimidazoles; Pharmaceutical Solutions; Polyethylene Glycols; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: a substudy from the BENEFIT trial.
Topics: Antiprotozoal Agents; Argentina; Brazil; Chagas Cardiomyopathy; Colombia; DNA, Protozoan; Double-Blind Method; Drug Monitoring; Humans; Molecular Diagnostic Techniques; Nitroimidazoles; Parasite Load; Parasitemia; Parasitology; Placebos; Randomized Controlled Trials as Topic; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Trypanosoma cruzi | 2013 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazole.
Topics: Drug Synergism; Membrane Potential, Mitochondrial; Nitroimidazoles; Plant Extracts; Sesquiterpenes, Guaiane; Tanacetum; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole.
Topics: Animals; Atrioventricular Block; Chagas Disease; Chronic Disease; Cicatrix; Collagen; Dogs; Drug Resistance; Electrocardiography; Fibrosis; Heart Atria; Myocardium; Nitroimidazoles; Prospective Studies; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease.
Topics: Adolescent; Adult; Chagas Disease; Chronic Disease; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
In vivo susceptibility to benznidazole of Trypanosoma cruzi strains from the western Brazilian Amazon.
Topics: Animals; Brazil; Chagas Disease; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Humans; Male; Marsupialia; Mice; Mice, Inbred Strains; Nitroimidazoles; Polymerase Chain Reaction; Species Specificity; Triatominae; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Multicenter epidemiological and clinical study on imported Chagas diseases in Alicante, Spain.
Topics: Adolescent; Adult; Aged; Antiprotozoal Agents; Bolivia; Chagas Disease; Child; Child, Preschool; Emigration and Immigration; Female; Hospitals, General; Humans; Infant; Male; Middle Aged; Nitroimidazoles; Pregnancy; Spain; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2012 |
[Trypanosoma cruzi strains resistant to benznidazole occurring in Colombia].
Topics: Animals; Chagas Disease; Colombia; Drug Resistance; Ecology; Humans; Insect Vectors; Nitroimidazoles; Opossums; Panstrongylus; Rats; Rhodnius; Rodent Diseases; Species Specificity; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.
Topics: Antiprotozoal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Blotting, Western; Gene Expression Profiling; Hep G2 Cells; Hepatocytes; Humans; Metabolic Networks and Pathways; Nitroimidazoles; Pregnane X Receptor; Real-Time Polymerase Chain Reaction; Receptors, Steroid; Up-Regulation | 2012 |
Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Dioxoles; Lignans; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Piper; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Unexpected performance of physical mixtures over solid dispersions on the dissolution behavior of benznidazole from tablets.
Topics: Drug Compounding; Excipients; Immunosuppressive Agents; Nitroimidazoles; Polyethylene Glycols; Solubility; Starch; Tablets; X-Ray Diffraction | 2013 |
A Practical Green Synthesis and Biological Evaluation of Benzimidazoles Against Two Neglected Tropical Diseases: Chagas and Leishmaniasis.
Topics: Amphotericin B; Antiprotozoal Agents; Benzimidazoles; Chagas Disease; Green Chemistry Technology; Heating; Leishmania mexicana; Leishmaniasis; Microwaves; Nifurtimox; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.
Topics: Animals; Chagas Disease; DNA, Protozoan; Drug Resistance; Exons; Genetic Variation; Genotype; Humans; Insect Vectors; Mexico; Microsatellite Repeats; Nifurtimox; Nitroimidazoles; Opossums; Phylogeny; Polymerase Chain Reaction; Triatoma; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Female; Intestines; Kidney; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua.
Topics: Allopurinol; Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Mice; Nicaragua; Nitroimidazoles; Survival Analysis; Treatment Outcome; Trypanosoma cruzi | 2013 |
New antiprotozoal agents: their synthesis and biological evaluations.
Topics: Amphotericin B; Antiprotozoal Agents; Cell Line; Cell Survival; Humans; Leishmania infantum; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Quinolines; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2013 |
Benznidazole prevents endothelial damage in an experimental model of Chagas disease.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Use of an enzyme-linked immunosorbent assay that utilizes the Tc13Tul antigen of Trypanosoma cruzi to monitor patients after treatment with benznidazole.
Topics: Antibodies, Protozoan; Antigens, Protozoan; Chagas Disease; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Infant; Nitroimidazoles; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi | 2013 |
P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance.
Topics: Adenosine Triphosphatases; Antiprotozoal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Gene Expression Profiling; Nitroimidazoles; Protozoan Proteins; Thiosemicarbazones; Trypanosoma cruzi | 2013 |
Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment.
Topics: Adolescent; Adult; Chagas Disease; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2013 |
Development of an ionic liquid-based dispersive liquid-liquid microextraction method for the determination of nifurtimox and benznidazole in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Ionic Liquids; Limit of Detection; Liquid Phase Microextraction; Nifurtimox; Nitroimidazoles; Reproducibility of Results; Trypanocidal Agents | 2013 |
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Chagas Disease; Disease Models, Animal; Infusions, Parenteral; Interferon-gamma; Interleukin-10; Male; Melastomataceae; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oleanolic Acid; Parasitemia; Random Allocation; Triterpenes; Trypanocidal Agents; Ursolic Acid | 2013 |
The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Skin Diseases; Steroids; Treatment Outcome; Young Adult | 2013 |
Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of nifurtimox and benznidazole.
Topics: Alcohol Drinking; Animals; Drug Interactions; Female; Male; Microsomes, Liver; Nifurtimox; Nitroimidazoles; Nitroreductases; Rats; Rats, Sprague-Dawley; Trypanocidal Agents | 2013 |
Clinical follow-up of responses to treatment with benznidazol in Amazon: a cohort study of acute Chagas disease.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibodies, Protozoan; Brazil; Chagas Cardiomyopathy; Chagas Disease; Child; Child, Preschool; Disease Progression; Follow-Up Studies; Humans; Immunoglobulin G; Middle Aged; Nitroimidazoles; Topography, Medical; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
Evaluation of the ELISA-F29 test as an early marker of therapeutic efficacy in adults with chronic Chagas disease.
Topics: Adolescent; Adult; Antibodies, Protozoan; Antigens, Protozoan; Case-Control Studies; Chagas Disease; Chronic Disease; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Retrospective Studies; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Donor-derived Trypanosoma cruzi infection in solid organ recipients in the United States, 2001-2011.
Topics: Adult; Aged; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Organ Transplantation; Polymerase Chain Reaction; Tissue Donors; Trypanosoma cruzi; United States | 2013 |
Stage-regulated GFP Expression in Trypanosoma cruzi: applications from host-parasite interactions to drug screening.
Topics: Animals; Chlorocebus aethiops; Drug Evaluation, Preclinical; Flow Cytometry; Fluorometry; Genes, Reporter; Green Fluorescent Proteins; Host-Parasite Interactions; Inhibitory Concentration 50; Microbial Viability; Nitroimidazoles; Organisms, Genetically Modified; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2013 |
Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity.
Topics: 4-Quinolones; Animals; BALB 3T3 Cells; Drug Design; Fibroblasts; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Inhibitory Concentration 50; Mice; Nitroimidazoles; Ribonucleosides; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
A simple and efficient HPLC method for benznidazole dosage in human breast milk.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Female; Healthy Volunteers; Humans; Lactation; Milk, Human; Nitroimidazoles; Trypanocidal Agents | 2013 |
Benznidazole modulates cell proliferation in acute leukemia cells.
Topics: Cell Cycle Checkpoints; Cell Death; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Gene Expression Regulation, Leukemic; HeLa Cells; Humans; Leukemia, Monocytic, Acute; Neoplasm Proteins; Nitroimidazoles; Trypanocidal Agents | 2013 |
Achievements and challenges upon the implementation of a program for national control of congenital Chagas in Bolivia: results 2004-2009.
Topics: Antiprotozoal Agents; Bolivia; Chagas Disease; Communicable Disease Control; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic | 2013 |
Modulation of biotransformation systems and ABC transporters by benznidazole in rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blotting, Western; Gene Expression; Glutathione Transferase; Intestinal Absorption; Isoenzymes; Male; Nitroimidazoles; Rats | 2013 |
Benznidazole treatment in chronic children infected with Trypanosoma cruzi: serological and molecular follow-up of patients and identification of Discrete Typing Units.
Topics: Adolescent; Antibodies, Protozoan; Antiprotozoal Agents; Argentina; Chagas Disease; Child; Child, Preschool; Chronic Disease; DNA, Kinetoplast; DNA, Protozoan; Female; Follow-Up Studies; Genotype; Humans; Male; Nitroimidazoles; Nucleic Acid Hybridization; Rural Population; Treatment Outcome; Trypanosoma cruzi | 2013 |
Selective activity of 2,4-diaryl-1,2,3,4-tetrahydroquinolines on Trypanosoma cruzi epimastigotes and amastigotes expressing β-galactosidase.
Topics: Animals; beta-Galactosidase; Cell Line; Chagas Disease; Fibroblasts; Gene Expression; Humans; Mice; Nitroimidazoles; Quinolines; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish.
Topics: Animals; Drug Evaluation, Preclinical; Embryo, Nonmammalian; High-Throughput Screening Assays; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Zebrafish | 2013 |
Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo.
Topics: Animals; Autophagy; Cell Membrane; Chagas Disease; Lactones; Liver; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Parasitic Sensitivity Tests; Sesquiterpenes; Survival Analysis; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Vacuoles | 2013 |
Interactive medical case. A patient with syncope.
Topics: Adult; Antibodies, Protozoan; Bundle-Branch Block; Chagas Cardiomyopathy; Defibrillators, Implantable; Diagnosis, Differential; Echocardiography; Electrocardiography; Humans; Immunoglobulin G; Male; Nitroimidazoles; Positron-Emission Tomography; Stroke Volume; Syncope; Tachycardia, Ventricular; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.
Topics: Animals; Biomarkers; CD8-Positive T-Lymphocytes; Chagas Disease; DNA; Drug Resistance; Drug Therapy, Combination; Immunophenotyping; Mice; Mice, Inbred C57BL; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.
Topics: Alleles; Animals; Cell Differentiation; Cell Line; Enzyme Inhibitors; Female; Flavin Mononucleotide; Heterozygote; Humans; Kinetics; Leishmania major; Mice; Mice, Inbred BALB C; Mustard Compounds; Nitroimidazoles; Nitroreductases; Prodrugs; Substrate Specificity; Trypanocidal Agents | 2013 |
Benznidazole treatment of chagasic encephalitis in pregnant woman with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiretroviral Therapy, Highly Active; Chagas Disease; Coinfection; Encephalitis; Female; Humans; Infant, Newborn; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2013 |
A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention.
Topics: Adolescent; Adult; Case-Control Studies; Chagas Disease; Child; Disease Progression; Female; Humans; Male; Nitroimidazoles; Polymerase Chain Reaction; Prognosis; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2013 |
Development of UV/HPLC methods for quantitative analysis of benznidazole in human plasma and urine for application in pediatric clinical studies.
Topics: Chagas Disease; Child; Chromatography, High Pressure Liquid; Freeze Drying; Humans; Nitroimidazoles; Specimen Handling; Trypanocidal Agents | 2013 |
Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole.
Topics: Chagas Disease; Crystallography, X-Ray; Humans; Models, Molecular; Nitroimidazoles; Spectrophotometry, Infrared; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Effects of benznidazole:cyclodextrin complexes on the drug bioavailability upon oral administration to rats.
Topics: Administration, Oral; Animals; Biological Availability; Calorimetry, Differential Scanning; Cyclodextrins; Kinetics; Male; Nitroimidazoles; Rats; Solubility; Thermogravimetry; X-Ray Diffraction | 2013 |
A study of photostability and compatibility of the anti-chagas drug Benznidazole with pharmaceutics excipients.
Topics: Chagas Disease; Chemistry, Pharmaceutical; Drug Stability; Excipients; Nitroimidazoles; Photolysis; Trypanocidal Agents | 2015 |
Towards a paradigm shift in the treatment of chronic Chagas disease.
Topics: Adolescent; Adult; Antibodies, Protozoan; Chagas Cardiomyopathy; Child; Chronic Disease; Disease Management; Drug Administration Schedule; Humans; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Anti-adrenergic and muscarinic receptor autoantibodies in a canine model of Chagas disease and their modulation by benznidazole.
Topics: Animals; Autoantibodies; Chagas Cardiomyopathy; Disease Models, Animal; Dogs; Humans; Immunosuppressive Agents; Nitroimidazoles; Receptor, Muscarinic M2; Receptors, Adrenergic, beta | 2014 |
Reversible cysteine protease inhibitors show promise for a Chagas disease cure.
Topics: Administration, Oral; Animals; Area Under Curve; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Life Cycle Stages; Male; Mice; Nitroimidazoles; Parasitemia; Protozoan Proteins; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi.
Topics: Animals; Cell Survival; Chagas Disease; DNA Glycosylases; DNA Repair; DNA Repair Enzymes; DNA, Protozoan; Drug Resistance; Guanine; Nitroimidazoles; Protozoan Proteins; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Imidazolium compounds are active against all stages of Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Imidazoles; Microscopy, Electron, Transmission; Mitochondria; Nitroimidazoles; Structure-Activity Relationship; Trypanosoma cruzi | 2014 |
Cytotoxic, mutagenic and genotoxic evaluation of crude extracts and fractions from Piper jericoense with trypanocidal action.
Topics: Cell Survival; Cells, Cultured; Chemical Fractionation; Culture Media; Humans; Life Cycle Stages; Lymphocytes; Mutagenicity Tests; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Piper; Plant Extracts; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Mother-to-child transmission of congenital Chagas disease, Japan.
Topics: Adolescent; Chagas Disease; Humans; Infectious Disease Transmission, Vertical; Japan; Male; Neglected Diseases; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Sesquiterpene lactone in nanostructured parenteral dosage form is efficacious in experimental Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Lactones; Mice; Nanocapsules; Nitroimidazoles; Sesquiterpenes; Trypanosoma cruzi | 2014 |
Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.
Topics: Antiprotozoal Agents; Codon, Nonsense; Drug Resistance; Gene Deletion; Nifurtimox; Nitroimidazoles; Nitroreductases; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2014 |
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants.
Topics: Antiparasitic Agents; Chorionic Villi; Female; Histocytochemistry; Humans; Immunohistochemistry; In Vitro Techniques; Microscopy, Fluorescence; Nifurtimox; Nitroimidazoles; Parasite Load; Placenta; Pregnancy; Real-Time Polymerase Chain Reaction; Trypanosoma cruzi | 2014 |
A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi.
Topics: Animals; Cell Line; Cell Membrane; Cell Proliferation; Cell Size; Drug Therapy, Combination; Humans; Intracellular Space; Life Cycle Stages; Macaca; Mice; Nitroimidazoles; Parasites; Quinoxalines; Toxicity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
[Paediatric Chagas in a non-endemic area].
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Emigrants and Immigrants; Humans; Infant; Infant, Newborn; Nitroimidazoles; Spain; Trypanocidal Agents | 2014 |
Alterations of mitochondria in liver but not in heart homogenates after treatment of rats with benznidazole.
Topics: Adenosine Diphosphate; Animals; Cell Respiration; Chemical and Drug Induced Liver Injury; Female; Membrane Potential, Mitochondrial; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membranes; Mitochondrial Proton-Translocating ATPases; Nitroimidazoles; Oxidative Phosphorylation; Rats, Wistar | 2014 |
Trypanosoma cruzi chemical proteomics using immobilized benznidazole.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Microspheres; Nitroimidazoles; Proteomics; Protozoan Proteins; Sepharose; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypanocidal Agents; Trypanosoma cruzi; Tubulin | 2014 |
Optical absorption of the antitrypanocidal drug benznidazole in water.
Topics: Nitroimidazoles; Quantum Theory; Solutions; Spectrophotometry, Ultraviolet; Thermodynamics; Trypanocidal Agents; Water | 2014 |
Identification of N-benzylacetamide as a major component of human plasmatic metabolic profiling of benznidazole.
Topics: Acetamides; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Nitroimidazoles; Tandem Mass Spectrometry; Trypanocidal Agents | 2015 |
In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.
Topics: Amidines; Animals; Cell Culture Techniques; Chagas Disease; Dose-Response Relationship, Drug; Heart; Humans; Nitroimidazoles; Parasitic Sensitivity Tests; Pentamidine; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Benznidazole drug delivery by binary and multicomponent inclusion complexes using cyclodextrins and polymers.
Topics: beta-Cyclodextrins; Drug Delivery Systems; Hydrophobic and Hydrophilic Interactions; Hypromellose Derivatives; Methylation; Nitroimidazoles; Povidone; Solubility; Trypanocidal Agents | 2012 |
In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi.
Topics: Amidines; Animals; Cell Survival; Chagas Disease; Galactosidases; Male; Mice; Nitroimidazoles; No-Observed-Adverse-Effect Level; Parasitemia; Primary Cell Culture; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Advancing the treatment for Chagas' disease.
Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents | 2014 |
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Topics: Administration, Oral; Animals; Biotransformation; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Nitroimidazoles; Sulfones; Sulfoxides; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.
Topics: Biotransformation; Glutathione; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Nitroimidazoles; Trypanosoma cruzi | 2014 |
A flagellated protozoa in the urine: other than Trichomonas.
Topics: Adult; Chagas Disease; Female; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Urine | 2014 |
Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Chagas Disease; Diagnosis, Differential; Female; Humans; Meningoencephalitis; Middle Aged; Nitroimidazoles; Toxoplasmosis, Cerebral; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Development of novel benznidazole formulations: physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease.
Topics: Animals; Calorimetry, Differential Scanning; Cellulose; Chagas Disease; Chemistry, Pharmaceutical; Crystallization; Deoxycholic Acid; Drug Carriers; Female; Mice; Microscopy, Electron, Scanning; Nitroimidazoles; Parasitemia; Powder Diffraction; Trypanocidal Agents; X-Ray Diffraction | 2014 |
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
Topics: Animals; Apoptosis; Artemisia; Chlorocebus aethiops; Lactones; Molecular Structure; Nifurtimox; Nitroimidazoles; Sesquiterpenes; Sesquiterpenes, Guaiane; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2014 |
Cerebral trypanosomiasis in a renal transplant recipient.
Topics: Adult; Brain Diseases; Central Nervous System Protozoal Infections; Chagas Disease; Humans; Kidney Transplantation; Male; Nitroimidazoles; Tomography, X-Ray Computed; Trypanocidal Agents | 2014 |
A clinical adverse drug reaction prediction model for patients with chagas disease treated with benznidazole.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Biomarkers; Chagas Disease; Drug-Related Side Effects and Adverse Reactions; Educational Status; Female; Humans; Logistic Models; Male; Nitroimidazoles; Racial Groups; Sex Factors; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2014 |
The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country.
Topics: Adult; Chagas Disease; Cytokines; Diseases in Twins; Female; HSP70 Heat-Shock Proteins; Humans; Immunity, Innate; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Spain; Trypanocidal Agents; Twins, Dizygotic | 2014 |
Short report: Increasing access to treatment for Chagas disease: the case of Morelos, Mexico.
Topics: Chagas Disease; Health Services Accessibility; Humans; Mexico; Nitroimidazoles; Trypanocidal Agents | 2014 |
Ruthenium complex with benznidazole and nitric oxide as a new candidate for the treatment of chagas disease.
Topics: Animals; Chagas Disease; Drug Resistance; Drug Therapy, Combination; Female; Heart; Humans; Inflammation; Mice; Nitric Oxide; Nitroimidazoles; Parasitemia; Ruthenium; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Development of a LC-MS/MS methodology for the monitoring of the antichagasic drug benznidazole in human urine.
Topics: Chagas Disease; Child; Chromatography, Liquid; Humans; Liquid-Liquid Extraction; Nitroimidazoles; Tandem Mass Spectrometry; Trypanocidal Agents | 2015 |
Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole.
Topics: Animals; Cell Death; Cell Line, Tumor; Chagas Disease; Chemical and Drug Induced Liver Injury; DNA Damage; Female; Hep G2 Cells; Humans; Liver; Male; Mice; Mitochondria; Nifurtimox; Nitrofurazone; Nitroimidazoles; Parasites; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Arthritis and benznidazole: more closely related than we thought.
Topics: Adult; Arthritis; Chagas Disease; Cohort Studies; Female; Humans; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2015 |
Rapid and sensitive ultra-high-pressure liquid chromatography method for quantification of antichagasic benznidazole in plasma: application in a preclinical pharmacokinetic study.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Linear Models; Male; Nitroimidazoles; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Trypanocidal Agents | 2015 |
First report of a family outbreak of Chagas disease in French Guiana and posttreatment follow-up.
Topics: Adolescent; Adult; Aged; Arecaceae; Chagas Disease; Child; Family; Female; French Guiana; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Plant Extracts; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
Topics: Amino Acid Sequence; Chromosome Mapping; Cyclophilins; DNA, Protozoan; Drug Resistance; Gene Dosage; Gene Expression Regulation; Genome, Protozoan; Nitroimidazoles; Phylogeny; RNA, Messenger; RNA, Protozoan; Sequence Alignment; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Profile of Trypanosoma cruzi infection in a tropical medicine reference center, Northern Italy.
Topics: Adolescent; Adult; Aged; Chagas Disease; Child; Echocardiography; Electrocardiography; Female; Humans; Italy; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Pregnancy; Retrospective Studies; Tropical Medicine; United States | 2014 |
Aptamer-based detection of disease biomarkers in mouse models for chagas drug discovery.
Topics: Animals; Antiprotozoal Agents; Aptamers, Nucleotide; Base Sequence; Biomarkers; Chagas Disease; Female; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nitroimidazoles; RNA | 2015 |
Novel solid dispersions of benznidazole: preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system.
Topics: Animals; Cells, Cultured; Cellulose; Chagas Disease; Cholagogues and Choleretics; Deoxycholic Acid; Drug Compounding; Drug Delivery Systems; Drug Liberation; Female; Fibroblasts; Freeze Drying; Humans; Inhibitory Concentration 50; Lethal Dose 50; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Tolerance of benznidazole in a United States Chagas Disease clinic.
Topics: Adolescent; Adult; Aged; Angioedema; Chagas Disease; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Nitroimidazoles; Peripheral Nervous System Diseases; Retrospective Studies; Trypanocidal Agents; United States; Young Adult | 2015 |
Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line.
Topics: Animals; Automation, Laboratory; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Myoblasts; Nifurtimox; Nitroimidazoles; Rats; Trypanosoma cruzi | 2015 |
Etiological treatment of Chagas disease patients with benznidazole lead to a sustained pro-inflammatory profile counterbalanced by modulatory events.
Topics: Adolescent; Adult; Chagas Disease; Controlled Before-After Studies; Cytokines; Female; Host-Pathogen Interactions; Humans; Immunomodulation; Inflammation Mediators; Male; Middle Aged; Neutrophils; Nitroimidazoles; Receptors, IgG; Toll-Like Receptor 4; Trypanocidal Agents; Young Adult | 2015 |
ABCG-like transporter of Trypanosoma cruzi involved in benznidazole resistance: gene polymorphisms disclose inter-strain intragenic recombination in hybrid isolates.
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Cloning, Molecular; Drug Resistance; Genes, Protozoan; Genetic Variation; Molecular Sequence Data; Nitroimidazoles; Parasitic Sensitivity Tests; Phylogeny; Polymorphism, Genetic; Recombination, Genetic; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Development of an ionic-liquid-based dispersive liquid-liquid microextraction method for the determination of antichagasic drugs in human breast milk: Optimization by central composite design.
Topics: Chagas Disease; Chromatography, High Pressure Liquid; Humans; Imidazoles; Ionic Liquids; Liquid Phase Microextraction; Milk, Human; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Ultraviolet Rays | 2015 |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease.
Topics: Animals; Antibodies, Protozoan; Area Under Curve; Brazil; Chagas Disease; Child; Disease Models, Animal; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Flow Cytometry; Humans; Inflammation; Mice; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Primary Cell Culture; Remission Induction; Statistics, Nonparametric; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients.
Topics: Administration, Oral; Chagas Disease; Child; Drug Compounding; Drug Stability; Drug Storage; Humans; Nitroimidazoles; Pediatrics; Spectrophotometry, Ultraviolet; Suspensions; Tablets; Taste | 2015 |
The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence.
Topics: Animals; Ascorbic Acid; Endoplasmic Reticulum; Gene Deletion; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide; Luminescent Measurements; Mice; Nitroimidazoles; Oxidative Stress; Peroxidases; Trypanocidal Agents; Trypanosoma cruzi; Virulence | 2015 |
Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease.
Topics: Alcohol Oxidoreductases; Animals; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Esters; Isoenzymes; Male; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Trypanosoma cruzi infection and benznidazole therapy independently stimulate oxidative status and structural pathological remodeling of the liver tissue in mice.
Topics: Animals; Chagas Disease; Liver; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Impact of benznidazole on infection course in mice experimentally infected with Trypanosoma cruzi I, II, and IV.
Topics: Animals; Chagas Disease; DNA, Protozoan; Male; Mice; Nitroimidazoles; Parasitemia; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole.
Topics: Animals; ATP-Binding Cassette Transporters; DNA, Protozoan; Drug Resistance; Genotype; Humans; Membrane Transport Proteins; Nitroimidazoles; Parasitic Sensitivity Tests; Phylogeny; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin.
Topics: Cell Adhesion Molecules; Cells, Cultured; Chagas Disease; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoxins; NF-kappa B; Nitroimidazoles; Signal Transduction; Simvastatin; Trypanocidal Agents | 2015 |
Access to care for Chagas disease in the United States: a health systems analysis.
Topics: Blood Donors; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Clinical Competence; Delivery of Health Care; Drugs, Investigational; Health Services Accessibility; Humans; Nifurtimox; Nitroimidazoles; Referral and Consultation; Systems Analysis; Trypanocidal Agents; United States | 2015 |
Prevention of congenital Chagas through treatment of girls and women of childbearing age.
Topics: Adolescent; Adult; Chagas Disease; Child; Cohort Studies; Female; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Primary Prevention; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2015 |
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Immunosuppression and Chagas disease; experience from a non-endemic country.
Topics: Adolescent; Adult; Aged; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunocompromised Host; Infant; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Spain; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2015 |
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Female; Immunoglobulin G; Itraconazole; Mice; Myocardium; Nitroimidazoles; Parasite Load; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice.
Topics: Administration, Oral; Animals; Antioxidants; Catalase; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glutathione Peroxidase; Ibuprofen; Immunosuppressive Agents; Inflammation; Male; Mice; Nitroimidazoles; Oxidative Stress; Random Allocation; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxide Dismutase | 2015 |
Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi.
Topics: Administration, Oral; Animals; Antibodies, Protozoan; Chagas Disease; Drug Administration Schedule; Drug Therapy, Combination; Immunoglobulin G; Injections, Intraperitoneal; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Parasite Load; Suramin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2015 |
In vivo and in vitro auranofin activity against Trypanosoma cruzi: Possible new uses for an old drug.
Topics: Animals; Antirheumatic Agents; Auranofin; Cell Line; Chagas Disease; Female; Fibroblasts; Humans; Inhibitory Concentration 50; Lethal Dose 50; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Random Allocation; Specific Pathogen-Free Organisms; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Toxic Profile of Benznidazole in Patients with Chronic Chagas Disease: Risk Factors and Comparison of the Product from Two Different Manufacturers.
Topics: Adult; Chagas Disease; Chronic Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Risk Factors; Treatment Outcome | 2015 |
An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase.
Topics: Animals; Chagas Disease; Cyclophosphamide; Immunocompromised Host; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Molecular Structure; Nitroimidazoles; Parasitemia; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
First solid-state NMR spectroscopy evaluation of complexes of benznidazole with cyclodextrin derivatives.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Carbon; Carbon-13 Magnetic Resonance Spectroscopy; Cyclodextrins; Nitroimidazoles; Protons; Time Factors | 2015 |
Evaluation of cytokine profile and HLA association in benznidazole related cutaneous reactions in patients with Chagas disease.
Topics: Adult; Alleles; Chagas Disease; Cytokines; Drug Eruptions; Female; Genes, MHC Class I; Genes, MHC Class II; HLA-B Antigens; Humans; Hypersensitivity, Delayed; Interleukin-10; Interleukin-5; Male; Nitroimidazoles; Prospective Studies; Skin; Th2 Cells; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
A flow cytometer-based method to simultaneously assess activity and selectivity of compounds against the intracellular forms of Trypanosoma cruzi.
Topics: Chagas Disease; Drug Discovery; Flow Cytometry; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM).
Topics: Adult; Chagas Cardiomyopathy; DNA, Protozoan; Heart Transplantation; Humans; Male; Nifurtimox; Nitroimidazoles; Phylogeny; Recurrence; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.
Topics: Administration, Oral; Animals; Chagas Disease; Dimethyl Sulfoxide; Disease Models, Animal; Diterpenes; Heart; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Salvia; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chagas Cardiomyopathy; Enalapril; Inflammation; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Perspectives in Chagas disease treatment.
Topics: Animals; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Death, Sudden, Cardiac; Defibrillators, Implantable; Disease Management; Heart Failure; Humans; Insect Control; Insect Vectors; Nifurtimox; Nitroimidazoles; Thromboembolism; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Gene Expression; Imidazoles; Immunosuppressive Agents; Male; Mice; Nitroimidazoles; Oxadiazoles; Parasitemia; Sex Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi.
Topics: Catalysis; Click Chemistry; Copper; Cycloaddition Reaction; Microwaves; Nitroimidazoles; Ruthenium; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydrazones; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Protozoan Proteins; Structure-Activity Relationship; Thiazolidines; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
[Postpartum treatment without interrupting breastfeeding in a patient with Chagas disease].
Topics: Breast Feeding; Chagas Disease; Female; Humans; Nitroimidazoles; Postpartum Period; Trypanocidal Agents; Young Adult | 2015 |
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients.
Topics: Adult; Chagas Disease; Chronic Disease; DNA, Kinetoplast; DNA, Satellite; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Liver; Male; Middle Aged; Nitroimidazoles; Pilot Projects; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Acute Chagas outbreaks: molecular and biological features of Trypanosoma cruzi isolates, and clinical aspects of acute cases in Santander, Colombia.
Topics: Acute Disease; Animals; Base Sequence; Chagas Disease; Colombia; Disease Outbreaks; DNA, Protozoan; Exons; Female; Genetic Variation; Genotype; Humans; Male; Molecular Sequence Data; Nifurtimox; Nitroimidazoles; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
The year in cardiology 2015: heart failure.
Topics: Alcohol Drinking; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Chagas Cardiomyopathy; Chronic Disease; Diabetes Mellitus, Type 2; Genetic Therapy; Heart Failure; Humans; Hypoglycemic Agents; Nitroimidazoles; Respiration, Artificial; Risk Factors; Sleep Apnea, Central; Trypanocidal Agents | 2016 |
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response.
Topics: Adolescent; Adult; Antiprotozoal Agents; Biomarkers; Chagas Disease; Chronic Disease; Drug Monitoring; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Thrombophilia; Treatment Outcome; Young Adult | 2016 |
Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations.
Topics: Antifungal Agents; Chagas Disease; Chemistry, Pharmaceutical; Drug Combinations; Humans; Itraconazole; Limit of Detection; Nitroimidazoles; Quality Control; Spectrophotometry; Trypanocidal Agents | 2016 |
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.
Topics: Abietanes; Amides; Chagas Disease; Humans; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis; Macrophages; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country.
Topics: Adult; Chagas Disease; Dermatitis, Exfoliative; Drug Eruptions; Edema; Female; Humans; Male; Nitroimidazoles; Stevens-Johnson Syndrome; Trypanocidal Agents | 2016 |
In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi.
Topics: Amides; Amidines; Animals; Chagas Disease; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Parasitic Sensitivity Tests; Structure-Activity Relationship; Survival Analysis; Terphenyl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Chagas Disease; DNA, Protozoan; Nitroimidazoles; Nitroreductases; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.
Topics: Animals; Cells, Cultured; Chagas Cardiomyopathy; Chagas Disease; Creatine Kinase; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Humans; Immunologic Factors; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Myocytes, Cardiac; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2016 |
Benznidazole Extended-Release Tablets for Improved Treatment of Chagas Disease: Preclinical Pharmacokinetic Study.
Topics: Adult; Animals; Antiprotozoal Agents; Biological Availability; Chagas Disease; Child; Delayed-Action Preparations; Humans; Male; Nitroimidazoles; Rabbits; Solubility; Tablets; Trypanosoma cruzi | 2016 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glutathione; Humans; Imidazoles; Nitroimidazoles; Polyamines; Spermidine; Thiophenes; Trypanosoma cruzi; User-Computer Interface | 2016 |
The BENEFIT Trial: Where Do We Go from Here?
Topics: Antiprotozoal Agents; Chagas Disease; Clinical Trials as Topic; Drug Evaluation; Humans; Nitroimidazoles; Trypanosoma cruzi; World Health Organization | 2016 |
Evaluation of Parasiticide Treatment with Benznidazol in the Electrocardiographic, Clinical, and Serological Evolution of Chagas Disease.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Protozoan; Brazil; Chagas Disease; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Treatment Outcome; Trypanocidal Agents | 2016 |
Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole.
Topics: Adult; Chagas Disease; Chemistry, Pharmaceutical; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2016 |
Curcumin Enhances the Anti-Trypanosoma cruzi Activity of Benznidazole-Based Chemotherapy in Acute Experimental Chagas Disease.
Topics: Acute Disease; Animals; Chagas Disease; Curcumin; Cytokines; Female; Liver; Mice; Myocardium; Nitroimidazoles; Parasitemia; Transaminases; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Chagas Disease; Female; Humans; Immunosuppressive Agents; Meningoencephalitis; Nitroimidazoles; Secondary Prevention; Survival Rate; Time Factors; Trypanocidal Agents; Ultrasonography | 2015 |
Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Synergism; Heart; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
A 12-mer repetitive antigenic epitope from Trypanosoma cruzi is a potential marker of therapeutic efficacy in chronic Chagas' disease.
Topics: Adult; Antigens, Protozoan; Antiprotozoal Agents; Biomarkers; C-Reactive Protein; Chagas Cardiomyopathy; Drug Monitoring; Epitopes; Humans; Interleukin-6; Nitroimidazoles; Therapeutics; Trypanosoma cruzi | 2016 |
Antiparasitic evaluation of betulinic acid derivatives reveals effective and selective anti-Trypanosoma cruzi inhibitors.
Topics: Animals; Annexin A5; Betulinic Acid; Coloring Agents; Drug Synergism; Flow Cytometry; Inhibitory Concentration 50; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nitroimidazoles; Pentacyclic Triterpenes; Propidium; Staining and Labeling; Triterpenes; Trypanocidal Agents; Trypanosoma cruzi; Ziziphus | 2016 |
Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses.
Topics: Adult; Antibodies, Protozoan; B-Lymphocytes; Chagas Disease; Drug Monitoring; Enzyme-Linked Immunospot Assay; Follow-Up Studies; Humans; Interferon-gamma; Middle Aged; Nitroimidazoles; Prognosis; T-Lymphocytes; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2016 |
Longitudinal study of patients with chronic Chagas cardiomyopathy in Brazil (SaMi-Trop project): a cohort profile.
Topics: Aged; Biomarkers; Brazil; Chagas Cardiomyopathy; Chronic Disease; Disease Progression; Female; Follow-Up Studies; Heart Failure; Humans; Immunosuppressive Agents; Longitudinal Studies; Male; Middle Aged; Natriuretic Peptide, Brain; Nitroimidazoles; Peptide Fragments; Population Surveillance; Predictive Value of Tests; Prognosis; Prospective Studies; Quality of Life; Socioeconomic Factors | 2016 |
Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease.
Topics: Animals; Chagas Disease; Female; Flow Cytometry; Heart Diseases; Immunohistochemistry; Mice; Mice, Inbred C57BL; Nitroimidazoles; Pentoxifylline; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).
Topics: Animals; Glutathione Disulfide; Glutathione Peroxidase; Hep G2 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Nitroimidazoles; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA, Small Interfering; Trypanocidal Agents | 2016 |
Chagas cardiomyopathy: The potential effect of benznidazole treatment on diastolic dysfunction and cardiac damage in dogs chronically infected with Trypanosoma cruzi.
Topics: Animals; Chagas Cardiomyopathy; Dogs; Female; Heart; Humans; Male; Models, Animal; Myocardium; Nitroimidazoles; Parasite Load; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina.
Topics: Adult; Antibodies, Protozoan; Antigens, Protozoan; Argentina; Chagas Disease; Chronic Disease; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Time Factors; Trypanocidal Agents; Young Adult | 2016 |
Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Carriers; Female; Life Cycle Stages; Mice; Mice, Inbred C3H; Myocytes, Cardiac; Nanoparticles; Nitroimidazoles; Parasitemia; Particle Size; Poloxamer; Primary Cell Culture; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.
Topics: Animals; Autophagy; Cell Membrane; Chagas Disease; Endoplasmic Reticulum; Flow Cytometry; Indazoles; Membrane Potential, Mitochondrial; Mice; Microscopy, Electron, Transmission; Mitochondria; Nitroimidazoles; Nuclear Envelope; Oxygen Consumption; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Animals; Chagas Disease; Chronic Disease; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Humans; Lactones; Mice; Nanocapsules; Nitroimidazoles; Polyethylene Glycols; Sesquiterpenes; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Phase Transitions of Isotropic to Anisotropic Biocompatible Lipid-Based Drug Delivery Systems Overcoming Insoluble Benznidazole Loading.
Topics: Animals; Biocompatible Materials; Cell Survival; Chlorocebus aethiops; Drug Carriers; Dynamic Light Scattering; Emulsions; Liquid Crystals; Microscopy; Nanostructures; Nitroimidazoles; Oils; Phase Transition; Rheology; Surface-Active Agents; Vero Cells; Water | 2016 |
[The third and new face of Chagas disease].
Topics: Adult; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Progression; Humans; Neglected Diseases; Nitroimidazoles; Treatment Failure | 2016 |
Vouching for access.
Topics: Chagas Disease; Cholera; Cholera Vaccines; Drug Approval; Drug Costs; Health Policy; Health Services Accessibility; Humans; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2016 |
Diagnosis and Treatment of Congenital Chagas Disease in a Premature Infant.
Topics: Chagas Disease; Diagnosis, Differential; Humans; Infant, Newborn; Infant, Premature; Male; Nitroimidazoles; Trypanocidal Agents | 2016 |
Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique.
Topics: Carboxymethylcellulose Sodium; Cellulose; Chemistry, Pharmaceutical; Drug Compounding; Drug Delivery Systems; Drug Implants; Excipients; Nitroimidazoles; Polyethylene Glycols; Polymethacrylic Acids; Solubility; Starch | 2017 |
Success of benznidazole chemotherapy in chronic Trypanosoma cruzi-infected patients with a sustained negative PCR result.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Female; Follow-Up Studies; Humans; Immunoassay; Male; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Prospective Studies; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes.
Topics: Animals; Chagas Disease; Electrophoresis, Gel, Two-Dimensional; Mice; Naphthoquinones; Nifurtimox; Nitroimidazoles; Proteomics; Protozoan Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
Topics: Alleles; Amino Acid Sequence; Animals; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Dihydrolipoamide Dehydrogenase; DNA, Protozoan; Drug Resistance; Gene Dosage; Gene Expression Regulation, Enzymologic; Mice; Mitochondria; Nitroimidazoles; Phylogeny; Real-Time Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; RNA, Protozoan; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Chronic Heart Disease after Treatment of Oral Acute Chagas Disease.
Topics: Acute Disease; Adolescent; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Chagas Disease; Electrocardiography; Humans; Male; Nitroimidazoles; Recurrence; Trypanocidal Agents | 2016 |
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Binding Sites; Drug Delivery Systems; Drug Design; Mice; Molecular Structure; Nitroimidazoles; Protein Binding; Pyridazines; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A | 2016 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; Macrophages; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Parasitemia; Pentamidine; Putrescine; Random Allocation; Spermidine; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Chagas Disease; Humans; Macrophages; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nitroimidazoles; Trypanocidal Agents; Up-Regulation | 2016 |
Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cells.
Topics: Apoptosis; Cell Hypoxia; DNA Breaks, Double-Stranded; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplastic Stem Cells; Nitroimidazoles; Tumor Microenvironment; Tumor Stem Cell Assay | 2016 |
Detection of Trypanosoma cruzi and Treatment Monitoring by PCR from Dried Blood Spot Samples in Children.
Topics: Adolescent; Argentina; Chagas Disease; Child; Child, Preschool; Dried Blood Spot Testing; Feasibility Studies; Female; Humans; Male; Nitroimidazoles; Polymerase Chain Reaction; Prospective Studies; Rural Population; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Benznidazole Use among Patients with Chronic Chagas' Cardiomyopathy in an Endemic Region of Brazil.
Topics: Aged; Brazil; Chagas Cardiomyopathy; Chronic Disease; Comorbidity; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Nitroimidazoles; Socioeconomic Factors; Trypanocidal Agents | 2016 |
Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis.
Topics: Animals; Antioxidants; Chagas Disease; Disease Models, Animal; Down-Regulation; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitroimidazoles; Oxidative Stress; Sepsis; Toll-Like Receptor 4; Trypanocidal Agents | 2017 |
Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis.
Topics: Algorithms; Animals; Chagas Disease; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Immunoblotting; Lasers; Motion; Nitroimidazoles; Photometry; Reagent Kits, Diagnostic; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dogs; Immunoglobulin G; Male; Mice; Myocarditis; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1 | 2017 |
In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi.
Topics: Animals; Animals, Wild; Australia; Cell Line; Drug Discovery; High-Throughput Screening Assays; Inhibitory Concentration 50; Melarsoprol; Nitroimidazoles; Phosphorylcholine; Potoroidae; Pyrimidines; Triazoles; Trypanocidal Agents; Trypanosoma; Trypanosoma cruzi | 2017 |
New Imidazole-Based Compounds Active Against Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Crystallography, X-Ray; Humans; Imidazoles; Mice; Models, Molecular; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Biological activity of the azlactone derivative EPA-35 against Trypanosoma cruzi.
Topics: Animals; Cell Cycle; Chlorocebus aethiops; Drug Discovery; Inhibitory Concentration 50; Lactones; Life Cycle Stages; Membrane Potential, Mitochondrial; Microscopy, Electron, Scanning; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2017 |
Long-term comparative pharmacovigilance of orally transmitted Chagas disease: first report.
Topics: Chagas Disease; Cross-Sectional Studies; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Pharmacovigilance; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Need to screen for Chagas disease and Strongyloides infestation in non-endemic countries prior to treatment with biologics.
Topics: Angioedema; Animals; Antibodies, Helminth; Antibodies, Protozoan; Antiprotozoal Agents; Antirheumatic Agents; Arthritis, Psoriatic; Bolivia; Chagas Disease; Disease Susceptibility; Drug Substitution; Endemic Diseases; Etanercept; Humans; Ivermectin; Nitroimidazoles; Patient Selection; Spain; Strongyloidiasis | 2017 |
Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols.
Topics: Animals; Cells, Cultured; Chagas Disease; Humans; Models, Molecular; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Pyridines; Pyrroles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Treatment of Infected Women of Childbearing Age Prevents Congenital Trypanosoma cruzi Infection by Eliminating the Parasitemia Detected by PCR.
Topics: Adult; Antibiotic Prophylaxis; Chagas Disease; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Parasitic; Prospective Studies; Trypanocidal Agents | 2017 |
Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial.
Topics: Animals; Chagas Cardiomyopathy; Chronic Disease; Clinical Trials as Topic; Disease Progression; Female; Humans; Latin America; Male; Middle Aged; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
A New Epoch in Antitrypanosomal Treatment for Chagas Disease.
Topics: Animals; Chagas Disease; Nitroimidazoles; Parasites; Triazoles | 2017 |
Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Nitroimidazoles; Parasitemia; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Transcriptome and Functional Genomics Reveal the Participation of Adenine Phosphoribosyltransferase in Trypanosoma cruzi Resistance to Benznidazole.
Topics: Adenine Phosphoribosyltransferase; DNA, Protozoan; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Gene Expression Profiling; Genomics; Nitroimidazoles; Phylogeny; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Interdisciplinary approach at the primary healthcare level for Bolivian immigrants with Chagas disease in the city of São Paulo.
Topics: Adolescent; Adult; Bolivia; Brazil; Chagas Disease; Child; Cross-Sectional Studies; Emigrants and Immigrants; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Mass Screening; Middle Aged; Nitroimidazoles; Patient Care Team; Primary Health Care; Serologic Tests; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2017 |
[Treatment and follow up of Chagas Disease in immunocompromised hosts].
Topics: Chagas Disease; Follow-Up Studies; HIV Infections; Humans; Immunocompetence; Immunocompromised Host; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents | 2017 |
Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole.
Topics: Drug Combinations; Drug Compounding; Nitroimidazoles; Solubility; Triazoles | 2017 |
Designing structural features of novel benznidazole-loaded cationic nanoparticles for inducing slow drug release and improvement of biological efficacy.
Topics: Drug Carriers; Drug Liberation; HEK293 Cells; Humans; Nanoparticles; Nitroimidazoles; Particle Size | 2017 |
[Estimating demand for anti-Chagas drugs: a contribution for access in Latin America].
Topics: Adolescent; Adult; Chagas Disease; Child; Child, Preschool; Humans; Infant; Latin America; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Young Adult | 2017 |
Effects of (1
Topics: Chagas Disease; Drug Combinations; Drug Synergism; Fluconazole; Humans; Ketoconazole; Nitroimidazoles; Pentanones; Trypanosoma cruzi | 2017 |
Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease.
Topics: Adult; Bolivia; Chagas Disease; Cohort Studies; Female; Humans; Logistic Models; Male; Middle Aged; Nitroimidazoles; Patient Compliance; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole.
Topics: Animals; Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Parasites; Triazoles | 2017 |
The immunomodulatory effects of the Enalapril in combination with Benznidazole during acute and chronic phases of the experimental infection with Trypanosoma cruzi.
Topics: Animals; Animals, Laboratory; Chagas Disease; Enalapril; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.
Topics: Adolescent; Adult; Chagas Disease; Cohort Studies; Disease Transmission, Infectious; Female; Humans; Infectious Disease Transmission, Vertical; Middle Aged; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanosoma cruzi; Young Adult | 2017 |
Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy.
Topics: Animals; Antiprotozoal Agents; Cells, Cultured; Chagas Disease; Drug Therapy, Combination; Metronidazole; Mice; Molecular Structure; Myocytes, Cardiac; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi.
Topics: Alcohol Dehydrogenase; Aldo-Keto Reductases; Animals; Chagas Disease; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Immunity, Innate; Nitroimidazoles; Protozoan Proteins; Receptors, Neurotensin; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Access to benznidazole for Chagas disease in the United States-Cautious optimism?
Topics: Centers for Disease Control and Prevention, U.S.; Chagas Disease; Drug Costs; Drugs, Investigational; Humans; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.
Topics: Antiprotozoal Agents; Chagas Disease; Cysteine Endopeptidases; High-Throughput Screening Assays; Host-Parasite Interactions; Humans; Kinetoplastida; Molecular Docking Simulation; Molecular Structure; Nifurtimox; Nitroimidazoles; Protein Domains; Protozoan Proteins; Trypanosoma cruzi | 2017 |
Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach.
Topics: Alcohols; Animals; Chagas Disease; Chemistry, Pharmaceutical; Child; Chlorocebus aethiops; Contraindications; Dosage Forms; Humans; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Polyethylene Glycols; Propylene Glycol; Solubility; Solvents; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells; Water | 2017 |
Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease.
Topics: Adolescent; Adult; Chagas Disease; Female; Humans; Male; Middle Aged; Nitroimidazoles; Risk Factors; Trypanocidal Agents; Young Adult | 2017 |
Benznidazole Nanoformulates: A Chance to Improve Therapeutics for Chagas Disease.
Topics: Chagas Disease; Chemical Phenomena; Cyclodextrins; Drug Carriers; Fibroblasts; Hep G2 Cells; Humans; Liposomes; Nanoparticles; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Diastole; Fenofibrate; Fibrosis; Humans; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; PPAR alpha; Stroke Volume; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha; Ventricular Dysfunction; Ventricular Function | 2017 |
[Rodolfo Viotti: clinical investigator in Chagas disease (1959-2017)].
Topics: Argentina; Chagas Disease; History, 20th Century; History, 21st Century; Humans; Nitroimidazoles; Research Personnel; Trypanocidal Agents | 2017 |
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Spanish group defeats Shkreli in Chagas voucher race.
Topics: Chagas Disease; Drug Industry; Drug Utilization Review; Humans; Neglected Diseases; Nitroimidazoles; Spain; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease.
Topics: Chagas Disease; Humans; Monitoring, Physiologic; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Triazoles; Trypanocidal Agents | 2017 |
FDA Gives First-Ever Approval of Drug To Treat Chagas' Disease.
Topics: Chagas Disease; Drug Approval; Humans; Nitroimidazoles; Trypanocidal Agents; United States; United States Food and Drug Administration | 2017 |
Timeline of events.
Topics: Antiprotozoal Agents; Biomedical Research; Chagas Disease; Cooperative Behavior; Cultural Diversity; Female; Hemorrhagic Fever, Ebola; Humans; Male; Nitroimidazoles; Nobel Prize; Patents as Topic; Research Support as Topic; Sex Factors; Social Discrimination; Social Justice; United States | 2017 |
Comment on: Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease.
Topics: Chagas Disease; Cohort Studies; Humans; Nitroimidazoles | 2018 |
Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease.
Topics: Animals; Antibodies, Protozoan; Cell Line; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Drug Carriers; Female; Heart; Inflammation; Mice; Mice, Inbred C3H; Nanoparticles; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2017 |
Efficacy of essential oil of Syzygium aromaticum alone and in combination with benznidazole on murine oral infection with Trypanosoma cruzi IV.
Topics: Animals; Chagas Disease; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Insect Vectors; Male; Mice; Nitroimidazoles; Oils, Volatile; Parasitemia; Plant Oils; Rhodnius; Syzygium; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease-authors' response.
Topics: Chagas Disease; Cohort Studies; Humans; Nitroimidazoles | 2018 |
The long road towards a safe and effective treatment of chronic Chagas disease.
Topics: Adult; Chagas Disease; Humans; Nitroimidazoles | 2018 |
Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Drug Combinations; Drug Synergism; Drugs, Investigational; Immunoglobulin G; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Triose-Phosphate Isomerase; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
A novel antibody surrogate biomarker to monitor parasite persistence in Trypanosoma cruzi-infected patients.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Biomarkers; Brazil; Chagas Disease; DNA, Protozoan; Humans; Immunoassay; Nitroimidazoles; Parasite Load; Parasitemia; Polymerase Chain Reaction; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi | 2018 |
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
Topics: Animals; Brain; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Female; Heart; Humans; Infant; Infectious Disease Transmission, Vertical; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Myocardium; Nifurtimox; Nitroimidazoles; Parasitemia; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Chagas disease knocks on our door: a cross-sectional study among Latin American immigrants in Milan, Italy.
Topics: Adolescent; Adult; Bolivia; Chagas Disease; Child; Cross-Sectional Studies; Data Accuracy; Drug Tolerance; El Salvador; Emigrants and Immigrants; Enzyme-Linked Immunosorbent Assay; Female; Hispanic or Latino; Humans; Immunoassay; Italy; Latin America; Male; Middle Aged; Nitroimidazoles; Prevalence; Risk Factors; Surveys and Questionnaires; Trypanosoma cruzi | 2018 |
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Trypanosoma cruzi infection of human induced pluripotent stem cell-derived cardiomyocytes: an in vitro model for drug screening for Chagas disease.
Topics: Cell Survival; Cells, Cultured; Chagas Disease; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Nitroimidazoles; Trypanosoma cruzi | 2018 |
Severe immune thrombocytopaenia in a patient taking benznidazole for chronic Chagas disease.
Topics: Adult; Chagas Disease; Chronic Disease; Female; Humans; Immunosuppressive Agents; Nitroimidazoles; Thrombocytopenia | 2018 |
Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening.
Topics: Animals; Antiprotozoal Agents; Discriminant Analysis; Drug Repositioning; Drug Resistance; Female; Humans; Metronidazole; Mice; Nitroimidazoles; Trichomonas Infections; Trichomonas vaginalis; Trichomonas Vaginitis | 2018 |
Drug reaction with eosinophilia and systemic symptoms syndrome induced by benznidazole.
Topics: Adult; Drug Hypersensitivity Syndrome; Eosinophilia; Female; Humans; Nitroimidazoles; Trypanocidal Agents | 2018 |
Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi.
Topics: Animals; Calcium Carbonate; Cell Death; Cell Line; Chagas Disease; Drug Delivery Systems; Epithelial Cells; Membrane Potential, Mitochondrial; Nanocapsules; Nitroimidazoles; Trypanosoma cruzi | 2018 |
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions.
Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Combinations; Drug Liberation; Drug Synergism; Models, Molecular; Nitroimidazoles; Povidone; Pyrrolidines; Triazoles; Trypanocidal Agents; Vinyl Compounds | 2018 |
Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes.
Topics: Adhesiveness; Administration, Oral; Animals; Capsules; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Liberation; Gelatin; Hydrophobic and Hydrophilic Interactions; Kinetics; Male; Mice, Inbred BALB C; Nitroimidazoles; Particle Size; Polyelectrolytes; Polymethacrylic Acids; Rheology; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Trypanocidal Agents | 2018 |
In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach.
Topics: Animals; Chagas Disease; Clomipramine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Inhibitory Concentration 50; Male; Mice; Multivariate Analysis; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Principal Component Analysis; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Male; Mice; Nifurtimox; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole release.
Topics: Adhesiveness; Administration, Oral; Alginates; Capsules; Chagas Disease; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Drug Liberation; Gelatin; Glucuronic Acid; Hexuronic Acids; Kinetics; Models, Chemical; Nitroimidazoles; Polyelectrolytes; Solubility; Solvents; Technology, Pharmaceutical; Trypanocidal Agents | 2018 |
Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4+CD8+ T cells in chronic Chagas disease patients.
Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Chronic Disease; Cytokines; Female; Humans; Interleukin-2; Leukocytes, Mononuclear; Male; Nitroimidazoles; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2018 |
Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail.
Topics: Adult; Chagas Disease; Chronic Disease; Cohort Studies; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nifurtimox; Nitroimidazoles; Prospective Studies; Retreatment; Trypanosoma cruzi | 2018 |
Chronic Chagas disease: therapeutic protocols and efficacy endpoints.
Topics: Adult; Chagas Disease; Humans; Nitroimidazoles | 2018 |
Repurposing Strategy of Atorvastatin against Trypanosoma cruzi:
Topics: Animals; Atorvastatin; Cell Line; Chagas Disease; Drug Repositioning; Drug Synergism; Drug Therapy, Combination; Heart; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Benefits of Ascorbic Acid in Association with Low-Dose Benznidazole in Treatment of Chagas Disease.
Topics: Animals; Antioxidants; Ascorbic Acid; Chagas Disease; Drug Therapy, Combination; Inflammation; Lipid Peroxidation; Male; Mice; Nitroimidazoles; Oxidation-Reduction; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular
Topics: Animals; Antiprotozoal Agents; Cell Cycle; Cell Line; Macaca mulatta; Metabolism; Nitroimidazoles; Stress, Physiological; Trypanosoma cruzi | 2018 |
In vitro and in vivo trypanocidal activities of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-cromen-2-one, a new synthetic coumarin of low cytotoxicity against mammalian cells.
Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Coumarins; Female; Mice; Nitroimidazoles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Preparation and Characterization of Poloxamer 407 Solid Dispersions as an Alternative Strategy to Improve Benznidazole Bioperformance.
Topics: Administration, Oral; Chagas Disease; Drug Carriers; Drug Liberation; Humans; Nitroimidazoles; Poloxamer; Solubility; Trypanocidal Agents; Trypanosoma cruzi; X-Ray Diffraction | 2018 |
Preclinical pharmacokinetics of benznidazole-loaded interpolyelectrolyte complex-based delivery systems.
Topics: Administration, Oral; Animals; Biological Availability; Dogs; Drug Liberation; Female; Male; Nitroimidazoles; Polymers; Trypanocidal Agents | 2018 |
Characteristics of Patients for Whom Benznidazole Was Released Through the CDC-Sponsored Investigational New Drug Program for Treatment of Chagas Disease - United States, 2011-2018.
Topics: Adolescent; Adult; Aged; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Child; Child, Preschool; Drugs, Investigational; Emigrants and Immigrants; Female; Humans; Infant; Infant, Newborn; Latin America; Male; Middle Aged; Nitroimidazoles; Trypanocidal Agents; United States; Young Adult | 2018 |
Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations.
Topics: Drug Resistance; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Nitroimidazoles; Peptide Initiation Factors; RNA-Binding Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
New Drugs 2018, part 3.
Topics: Acetates; Boronic Acids; Drug Approval; Drug Combinations; Fluoroquinolones; Humans; Meropenem; Metronidazole; Nitroimidazoles; Parathyroid Hormone-Related Protein; Peptides; Prostaglandins F, Synthetic; Quinazolines; Thienamycins; United States; United States Food and Drug Administration | 2018 |
Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
Topics: Animals; Ascorbic Acid; Body Weight; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Mice, Inbred C3H; Nitroimidazoles; Parasite Load; Parasitemia; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chronic Disease; Collagen Type III; Disease Models, Animal; Disease Progression; DNA, Protozoan; Dogs; Drug Resistance; Fibrosis; Heart; Myocardium; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Experimental combination therapy using low doses of benznidazole and allopurinol in mouse models of Trypanosoma cruzi chronic infection.
Topics: Allopurinol; Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitroimidazoles; Random Allocation; Specific Pathogen-Free Organisms; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.
Topics: Animals; Chagas Disease; Disease Models, Animal; Inflammation; Kidney; Liver; Male; Mice; Muscle, Skeletal; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 2018 |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Carvedilol; Catalase; Chagas Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart; Male; Mice, Inbred C57BL; Myocardium; Nitroimidazoles; Oxidative Stress; Parasitemia; Protein Carbonylation; Reference Values; Reproducibility of Results; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study.
Topics: Aftercare; Brazil; Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; National Institutes of Health (U.S.); Nitroimidazoles; Parasitemia; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi; United States | 2018 |
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Flow Cytometry; Indoles; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement.
Topics: Brain; Chagas Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Nitroimidazoles | 2019 |
In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex.
Topics: Animals; Chagas Disease; Coordination Complexes; Copper; Female; Hydrazines; Hydrogen Bonding; Ligands; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Nitroimidazoles; Pyridines; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Tailoring microstructural, drug release properties, and antichagasic efficacy of biocompatible oil-in-water benznidazol-loaded nanoemulsions.
Topics: Animals; Cell Line; Chagas Disease; Chemistry, Pharmaceutical; Chlorocebus aethiops; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Emulsions; Humans; Inhibitory Concentration 50; Liquid Crystals; Nanostructures; Nitroimidazoles; Phase Transition; Solubility; Solvents; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2019 |
Chagas disease: An underrecognized diagnosis.
Topics: Acute-Phase Reaction; Cardiomyopathies; Chagas Disease; Chronic Disease; Diagnosis, Differential; Female; Humans; Male; Megacolon; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States | 2018 |
Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease.
Topics: Chagas Disease; Chronic Disease; Cross-Sectional Studies; Cytokines; Echocardiography; Female; Heart; Humans; Interleukin-17; Male; Middle Aged; Mitral Valve; Myocardium; Nitroimidazoles | 2019 |
New polyamine drugs as more effective antichagas agents than benznidazole in both the acute and chronic phases.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Design; Fluorenes; Humans; Microbodies; Nitroimidazoles; Polyamines; Solubility; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Nitroimidazoles; Protozoan Proteins; Sterol 14-Demethylase; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi.
Topics: Antiprotozoal Agents; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Associated Protein 9; Electroporation; Gene Expression; Gene Knockout Techniques; Genetics, Microbial; Molecular Biology; Nifurtimox; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanosoma cruzi | 2019 |
A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development.
Topics: Chagas Disease; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Protozoan Vaccines; Trypanocidal Agents; Trypanosoma cruzi; Vaccination | 2019 |
Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Drug Repositioning; Drug Therapy, Combination; Fibroblasts; Imatinib Mesylate; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Host-Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Humans; Nitroimidazoles; Prognosis; Thrombin; Thrombophilia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Trypanosoma cruzi-Specific T-Cell Responses to Monitor Treatment Efficacy in Chronic Chagas Disease.
Topics: Cells, Cultured; Chagas Disease; Chronic Disease; Humans; Immunity, Cellular; Immunoenzyme Techniques; Leukocytes, Mononuclear; Nitroimidazoles; Prognosis; T-Lymphocytes; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Cardiac Evaluation in the Acute Phase of Chagas' Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil.
Topics: Adolescent; Adult; Brazil; Chagas Cardiomyopathy; Chagas Disease; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
Does Progressive Introduction of Benznidazole Reduce the Chance of Adverse Events in the Treatment of Chagas Disease?
Topics: Adult; Chagas Disease; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Trypanocidal Agents | 2019 |
Insights into Chagas treatment based on the potential of bacteriocin AS-48.
Topics: Animals; Bacteriocins; Chagas Disease; Enterococcus faecalis; Mitochondria; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi.
Topics: Allopurinol; Animals; Cell Line; Chagas Disease; Humans; Mice; Mortality; Nifurtimox; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanosoma cruzi | 2019 |
Developments on treatment of Chagas disease - from discovery to current times.
Topics: Chagas Disease; Drug Repositioning; Humans; Molecular Structure; Nifurtimox; Nitroimidazoles; Prognosis; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Activity of natural and synthetic polygodial derivatives against
Topics: Animals; Cell Line; Humans; Life Cycle Stages; Nitroimidazoles; Sesquiterpenes; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Impact of levamisole in co-administration with benznidazole on experimental Chagas disease.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Levamisole; Male; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis.
Topics: Acute Disease; Chagas Disease; Fatal Outcome; Food Parasitology; Humans; Infant; Male; Nitroimidazoles; Prognosis; Trypanocidal Agents | 2019 |
Self-Assembled Benznidazole-Loaded Cationic Nanoparticles Containing Cholesterol/Sialic Acid: Physicochemical Properties, In Vitro Drug Release and In Vitro Anticancer Efficacy.
Topics: Antineoplastic Agents; Cations; Cell Death; Chemical Phenomena; Cholesterol; Drug Compounding; Drug Liberation; HEK293 Cells; HeLa Cells; HT29 Cells; Humans; Kinetics; N-Acetylneuraminic Acid; Nanoparticles; Nitroimidazoles; Particle Size; Spectroscopy, Fourier Transform Infrared; Static Electricity; Surface Properties | 2019 |
Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients.
Topics: Cardiomyopathies; Chagas Disease; Chronic Disease; Cost-Benefit Analysis; Disease Progression; Humans; Nitroimidazoles; Trypanosoma cruzi; Vaccination; Vaccines | 2019 |
Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole.
Topics: DNA, Protozoan; Drug Resistance; Gene Expression; Humans; Macrophages; Nitroimidazoles; Oxidative Stress; Phylogeny; Real-Time Polymerase Chain Reaction; THP-1 Cells; Trypanosoma cruzi | 2019 |
Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis.
Topics: Animals; Antioxidants; Cardiotonic Agents; Catalase; Chagas Cardiomyopathy; Chagas Disease; Cytokines; Disease Models, Animal; Heart; Inflammation; Interleukin-10; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Superoxide Dismutase; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2019 |
Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
Topics: Amide Synthases; Antioxidants; Buthionine Sulfoximine; Cell Line; Drug Combinations; Drug Resistance; Fibroblasts; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Humans; Hydrogen Peroxide; NADH, NADPH Oxidoreductases; Nitroimidazoles; Oxidation-Reduction; Oxidative Stress; Peroxidases; Protozoan Proteins; Signal Transduction; Spermidine; Thioredoxins; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cells, Cultured; Cytokines; Gene Expression Regulation; Inflammation Mediators; Interleukin-10; Lipopolysaccharides; Mice; Mice, Knockout; Myocytes, Cardiac; NF-kappa B; Nitric Oxide; Nitroimidazoles; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2019 |
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement.
Topics: Antineoplastic Agents; Benzene; Benzoates; Cyclooctanes; Molecular Structure; Nitroimidazoles; Tetrahydronaphthalenes | 2019 |
Recognition for Chagas disease.
Topics: Chagas Disease; Humans; Latin America; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Benznidazole, itraconazole and their combination in the treatment of acute experimental chagas disease in dogs.
Topics: Acute Disease; Animals; Chagas Disease; DNA, Protozoan; Dogs; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Heart; Humans; Itraconazole; Male; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Trypanocidal Agents | 2019 |
In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents.
Topics: Blood Cells; Cell Survival; Comet Assay; DNA Damage; Humans; Micronucleus Tests; Nifurtimox; Nitroimidazoles; Reference Values; Reproducibility of Results; Thiadiazoles; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Anthelmintic resistance in hair sheep farms in a sub-humid tropical climate, in the Huasteca Potosina, Mexico.
Topics: Alleles; Animals; Anthelmintics; Drug Resistance; Feces; Female; Humidity; Intestinal Diseases, Parasitic; Lactones; Lethal Dose 50; Male; Mexico; Nematode Infections; Nitroimidazoles; Parasite Egg Count; Polymerase Chain Reaction; Sheep; Sheep Diseases; Thiazoles; Tropical Climate | 2019 |
Antichagasic effect of violacein from Chromobacterium violaceum.
Topics: Apoptosis; Cell Line; Cell Survival; Chromobacterium; Drug Resistance; Humans; Indoles; Mitochondria; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Reactivation of Chagas disease in a heart transplant patient infected by sylvatic Trypanosoma cruzi discrete typing unit I.
Topics: Chagas Cardiomyopathy; DNA, Protozoan; Genetic Variation; Genotype; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Nitroimidazoles; Polymerase Chain Reaction; Trypanocidal Agents | 2019 |
Combination therapy with benznidazole and doxycycline shows no additive effect to monotherapy with benznidazole in mice infected with the VL-10 strain of the Trypanosoma cruzi.
Topics: Animals; Anti-Bacterial Agents; Chagas Disease; Doxycycline; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Phenothiazinium Dyes Are Active against
Topics: Animals; Cell Line; Cell Proliferation; Chagas Disease; Coloring Agents; Humans; Methylene Blue; Nifurtimox; Nitroimidazoles; Phenothiazines; Tolonium Chloride; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Chagas Disease; Cytokines; Disease Models, Animal; Drug Administration Schedule; Heart; Male; Myocarditis; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Running; Trypanosoma cruzi | 2019 |
Activity of the sesquiterpene lactone goyazensolide against
Topics: Animals; Bridged-Ring Compounds; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Furans; Mice; Nitroimidazoles; Sesquiterpenes; Sesterterpenes; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
An evaluation of benznidazole as a Chagas disease therapeutic.
Topics: Adult; Chagas Disease; Child; Female; Humans; Nitroimidazoles; Prognosis; Trypanocidal Agents | 2019 |
Longitudinal follow up of serological response in children treated for Chagas disease.
Topics: Adolescent; Antibodies, Protozoan; Antibody Formation; Antiprotozoal Agents; Chagas Disease; Child; Child, Preschool; Drug Monitoring; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Nitroimidazoles; Prospective Studies; Treatment Outcome; Trypanosoma cruzi; Young Adult | 2019 |
Mapping benznidazole resistance in trypanosomatids and exploring evolutionary histories of nitroreductases and ABCG transporter protein sequences.
Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily G; ATP-Binding Cassette Transporters; Chagas Disease; Drug Resistance; Geography; Humans; Membrane Transport Proteins; Nitroimidazoles; Nitroreductases; Phylogeny; Trypanocidal Agents; Trypanosoma | 2019 |
IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia.
Topics: Adolescent; Biomarkers; Bolivia; Chagas Disease; Child; Child, Preschool; Cytokines; Female; Follow-Up Studies; Humans; Interleukin-17; Male; Nitroimidazoles; Polymerase Chain Reaction; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Chronic Disease; Clofazimine; Combined Modality Therapy; Dihydropyridines; Female; Humans; Mice; Mice, Inbred C3H; Nitroimidazoles; Trypanocidal Agents; Vero Cells | 2019 |
Immunological exhaustion and functional profile of CD8
Topics: Biomarkers; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Costimulatory and Inhibitory T-Cell Receptors; Cytokines; Humans; Nitroimidazoles; Programmed Cell Death 1 Receptor; Signaling Lymphocytic Activation Molecule Family; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy.
Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Cell Line; Chagas Disease; Cytokines; Female; Immunologic Factors; Inflammation; Lactones; Mice; Myocarditis; Nitroimidazoles; Parasitemia; Rats; Sesquiterpenes; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2019 |
Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: a prospective cohort study in two Spanish referral centres.
Topics: Adult; Chagas Disease; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Referral and Consultation; Spain; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease.
Topics: Adult; Chagas Disease; Chronic Disease; Drug Tolerance; Humans; Nifurtimox; Nitroimidazoles; Switzerland; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Transbuccal delivery of benznidazole associated with monoterpenes: permeation studies and mechanistic insights.
Topics: Administration, Buccal; Animals; Monoterpenes; Mouth Mucosa; Nitroimidazoles; Permeability; Swine; Trypanocidal Agents | 2020 |
Differential phenotypic and functional profile of epitope-specific cytotoxic CD8
Topics: Adult; Biomarkers; CD8-Positive T-Lymphocytes; Chagas Disease; Cytokines; Epitopes; Female; Humans; Leukocytes, Mononuclear; Male; Nitroimidazoles; Phenotype; Trypanosoma cruzi | 2020 |
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis.
Topics: Aspirin; Cells, Cultured; Chagas Disease; Gene Expression; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Nitroimidazoles; Receptor, Notch1; Simvastatin; Trypanosoma cruzi | 2020 |
Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon.
Topics: Acute Disease; Animals; Blood; Chagas Disease; Chronic Disease; Colon; Cyclophosphamide; Female; Heart; Immunosuppression Therapy; Mice; Neglected Diseases; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Benznidazole self-emulsifying delivery system: A novel alternative dosage form for Chagas disease treatment.
Topics: Animals; Caco-2 Cells; Cell Survival; Chagas Disease; Dosage Forms; Dose-Response Relationship, Drug; Drug Delivery Systems; Emulsifying Agents; Female; Hep G2 Cells; Humans; Mice; Nitroimidazoles; Rats; Trypanocidal Agents | 2020 |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil.
Topics: Adult; Brazil; Chagas Disease; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Fluorescent Antibody Technique, Indirect; Hemagglutination Tests; Hospitals, Public; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Severity of Illness Index; Socioeconomic Factors; Trypanocidal Agents | 2020 |
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents | 2020 |
Usefulness of real-time PCR during follow-up of patients treated with Benznidazole for chronic Chagas disease: Experience in two referral centers in Barcelona.
Topics: Chagas Disease; Chronic Disease; Humans; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Retrospective Studies; Spain; Trypanocidal Agents | 2020 |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocardiography; Male; Mice; Naphthoquinones; Nitroimidazoles; Parasitemia; Time Factors; Trypanocidal Agents | 2020 |
The Clinical and Parasitologic Follow-up of Trypanosoma cruzi-infected Children in a Nonendemic Country.
Topics: Adolescent; Chagas Disease; Child; Child, Preschool; Chronic Disease; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Nitroimidazoles; Prospective Studies; Spain; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Congenital Chagas Disease in the United States: The Effect of Commercially Priced Benznidazole on Costs and Benefits of Maternal Screening.
Topics: Chagas Disease; Cost Savings; Cost-Benefit Analysis; Female; Humans; Infectious Disease Transmission, Vertical; Mass Screening; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents; United States | 2020 |
State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response.
Topics: Biomarkers; Chagas Disease; Chronic Disease; Gastrointestinal Tract; Heart; Host-Parasite Interactions; Humans; Nifurtimox; Nitroimidazoles; Prognosis; Treatment Outcome; Trypanosoma cruzi | 2020 |
Pregnancy and Chagas Disease: Benznidazole's Impact on Pregnancy and Newborns: A Report of Four Cases.
Topics: Adolescent; Adult; Bolivia; Chagas Disease; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Nitroimidazoles; Pregnancy; Pregnancy Complications, Parasitic; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
A Novel Prototype Device for Microencapsulation of Benznidazole: In Vitro/In Vivo Studies.
Topics: Animals; Chitosan; Drug Compounding; Drug Liberation; Nitroimidazoles; Rats; Rats, Wistar | 2020 |
Efficacy of continuous versus intermittent administration of nanoformulated benznidazole during the chronic phase of Trypanosoma cruzi Nicaragua infection in mice.
Topics: Animals; Chagas Disease; Humans; Mice; Mice, Inbred C57BL; Nicaragua; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Population pharmacokinetics and biodistribution of benznidazole in mice.
Topics: Animals; Chagas Disease; Humans; Mice; Nitroimidazoles; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Wasp venom peptide as a new antichagasic agent.
Topics: Animals; Apoptosis; Cell Line; Flow Cytometry; Membrane Potential, Mitochondrial; Nitroimidazoles; Peptides; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Wasp Venoms; Wasps | 2020 |
Combination Therapy Using Benznidazole and Aspirin during the Acute Phase of Experimental Chagas Disease Prevents Cardiovascular Dysfunction and Decreases Typical Cardiac Lesions in the Chronic Phase.
Topics: Animals; Aspirin; Chagas Disease; Drug Combinations; Humans; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Aspartate Aminotransferases; Chagas Disease; Chronic Disease; Disease Models, Animal; Excipients; Female; Heart; Mice; Myocardium; Nitroimidazoles; Parasitemia; Poloxamer; Quadriceps Muscle; Random Allocation; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?
Topics: Animals; Antiprotozoal Agents; Chagas Cardiomyopathy; Chagas Disease; Drug Therapy, Combination; Female; Mice; Myocarditis; Nitroimidazoles; Phenothiazines; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
HLA-A∗68, -A∗11:01, and -A∗29:02 alleles are strongly associated with benznidazole-induced maculopapular exanthema (MPE)/DRESS.
Topics: Alleles; Anticonvulsants; Exanthema; HLA-A Antigens; Humans; Nitroimidazoles | 2020 |
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
Topics: Acetylglucosaminidase; Animals; Chagas Disease; Cytokines; Disease Models, Animal; Drug Combinations; Female; Glycogen; Hepatitis; Mice; Muscle, Skeletal; Myositis; NADH, NADPH Oxidoreductases; Nitroimidazoles; Parasite Load; Parasitemia; Peroxidase; Thioridazine; Transaminases; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Identification of Inhibitors to
Topics: Animals; Cell Line; Chagas Disease; Drug Synergism; Epithelial Cells; Group III Histone Deacetylases; Inhibitory Concentration 50; Macaca mulatta; Molecular Docking Simulation; Nitroimidazoles; Phylogeny; Recombinant Proteins; Sirtuins; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant
Topics: Animals; Cell Line; Chagas Disease; Drug Resistance; Drug Therapy, Combination; Humans; Indazoles; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Access to Chagas disease treatment in the United States after the regulatory approval of benznidazole.
Topics: Age Factors; Centers for Disease Control and Prevention, U.S.; Chagas Disease; Drug Costs; Drugs, Investigational; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi; United States; United States Food and Drug Administration | 2020 |
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.
Topics: Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Pilot Projects; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.
Topics: Chagas Disease; Drug Discovery; Humans; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity.
Topics: Dialysis; Drug Carriers; Humans; Hydrogen-Ion Concentration; Imidazoles; Nitroimidazoles; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Trypanocidal Agents; Zeolites | 2020 |
Benznidazole for the treatment of Chagas disease.
Topics: Adult; Chagas Disease; Disease Progression; Female; Humans; Infectious Disease Transmission, Vertical; Nitroimidazoles; Pregnancy; Pregnancy Complications, Infectious; Trypanocidal Agents | 2021 |
"We have already heard that the treatment doesn't do anything, so why should we take it?": A mixed method perspective on Chagas disease knowledge, attitudes, prevention, and treatment behaviour in the Bolivian Chaco.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Bolivia; Chagas Disease; Cross-Sectional Studies; Family Characteristics; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Middle Aged; Nitroimidazoles; Patient Acceptance of Health Care; Socioeconomic Factors; Surveys and Questionnaires; Young Adult | 2020 |
A novel Trypanosoma cruzi secreted antigen as a potential biomarker of Chagas disease.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Antigens, Protozoan; Biomarkers; Chagas Disease; Humans; Macaca mulatta; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Middle Aged; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Effect of capsaicin on the protozoan parasite Trypanosoma cruzi.
Topics: Arginine Kinase; Capsaicin; Chagas Disease; Enzyme Activation; Inhibitory Concentration 50; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Evaluation of the anti-Trypanosoma cruzi activity in vitro and in vivo of silibinin and silibinin in association to benznidazole.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Female; Heart; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitemia; Real-Time Polymerase Chain Reaction; Silybin; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2021 |
Dual chemotherapy with benznidazole at suboptimal dose plus curcumin nanoparticles mitigates Trypanosoma cruzi-elicited chronic cardiomyopathy.
Topics: Animals; Chagas Cardiomyopathy; Chronic Disease; Curcumin; Female; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
In vitro susceptibility to benznidazole, nifurtimox and posaconazole of Trypanosoma cruzi isolates from Paraguay
Topics: Analysis of Variance; Genotype; Lethal Dose 50; Nifurtimox; Nitroimidazoles; Paraguay; Phenotype; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Female; Mice; Nanoparticles; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Development and characterization of thermopressed polyvinyl alcohol films for buccal delivery of benznidazole.
Topics: Drug Compounding; Drug Delivery Systems; Drug Liberation; Humans; Nitroimidazoles; Polyvinyl Alcohol | 2021 |
Benznidazole: Hero or villain of cellular immune response in chronic Chagas disease patients?
Topics: Antigen Presentation; B7-1 Antigen; Cells, Cultured; Chagas Disease; Chronic Disease; HLA-DR Antigens; Humans; Immunity, Cellular; Leukocytes, Mononuclear; Lymphocyte Activation; Macrophage Activation; Nitroimidazoles; Phagocytosis; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers.
Topics: Acute Disease; Animals; CD8-Positive T-Lymphocytes; Chagas Disease; Female; Mice; Mice, Inbred C57BL; Nitroimidazoles; Spleen; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems.
Topics: Anacardium; Chagas Disease; Computer Simulation; Drug Delivery Systems; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microwaves; Molecular Structure; Nanoparticles; Nitroimidazoles; Particle Size; Phthalic Acids; Plant Gums; Spectroscopy, Fourier Transform Infrared; Trypanocidal Agents | 2021 |
Benznidazole modulates release of inflammatory mediators by cardiac spheroids infected with Trypanosoma cruzi.
Topics: Animals; Imaging, Three-Dimensional; Mice; Microscopy, Fluorescence; Molecular Conformation; Nitroimidazoles; Spheroids, Cellular; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Memory impairment in chronic experimental Chagas disease: Benznidazole therapy reversed cognitive deficit in association with reduction of parasite load and oxidative stress in the nervous tissue.
Topics: Animals; Chagas Disease; Chronic Disease; Cognition; Cognitive Dysfunction; Female; Mice, Inbred C57BL; Nitroimidazoles; Oxidative Stress; Parasite Load; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
The ubiquinone synthesis pathway is a promising drug target for Chagas disease.
Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Line, Tumor; Chagas Disease; Drug Delivery Systems; HeLa Cells; Humans; Mammals; Nitroimidazoles; Signal Transduction; Trypanocidal Agents; Trypanosoma cruzi; Ubiquinone | 2021 |
A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment.
Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; Chagas Disease; Female; Granzymes; Humans; Interferon-gamma; Male; Middle Aged; Nitroimidazoles; Perforin; Spain; Trypanosoma cruzi; Young Adult | 2021 |
Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution.
Topics: Calorimetry, Differential Scanning; Carbon Dioxide; gamma-Cyclodextrins; Nitroimidazoles; Solubility | 2021 |
Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Female; Interleukin-17; Mice; Mice, Inbred BALB C; Nitroimidazoles; Protozoan Vaccines; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Therapy, Combination; Humans; Male; Mice; Nitroimidazoles; Oils, Volatile; Parasite Load; Plant Oils; Syzygium; Trypanosoma cruzi; Zingiber officinale | 2021 |
Pharmacogenomic Profile and Adverse Drug Reactions in a Prospective Therapeutic Cohort of Chagas Disease Patients Treated with Benznidazole.
Topics: Brazil; Chagas Disease; Female; Gene Regulatory Networks; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Nitroimidazoles; Polymorphism, Single Nucleotide; Prospective Studies; Risk; Signal Transduction; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.
Topics: Chagas Disease; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Levels of anti-B13 antibodies over time in a cohort of chronic infected by Trypanosoma cruzi. Its relationship with specific treatment and clinical status.
Topics: Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Argentina; Chagas Disease; Chronic Disease; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Nifurtimox; Nitroimidazoles; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2021 |
Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Mice; Nanoparticle Drug Delivery System; Nitroimidazoles; Phagocytes; Polyethylene Glycols; Sulfides; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier.
Topics: Area Under Curve; Biological Availability; Chagas Disease; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Drug Liberation; Excipients; Humans; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Kinetics; Metal-Organic Frameworks; Microscopy, Electron, Scanning; Nitroimidazoles; Solubility; Trypanosoma cruzi; X-Ray Diffraction; Zeolites | 2021 |
Unraveling the antitrypanosomal mechanism of benznidazole and related 2-nitroimidazoles: From prodrug activation to DNA damage.
Topics: Activation, Metabolic; DNA Breaks, Double-Stranded; DNA Repair; Genome, Protozoan; Nitroimidazoles; Nitroreductases; Prodrugs; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2021 |
IgG Subclass Analysis in Patients with Chagas Disease 4 Years After Benznidazole Treatment.
Topics: Chagas Disease; Humans; Immunoglobulin G; Nitroimidazoles; Parasitemia | 2021 |
Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy.
Topics: Animals; Chagas Disease; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Intrinsic and Chemotherapeutic Stressors Modulate ABCC-Like Transport in
Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Chagas Disease; Drug Resistance; Glutathione; Nitroimidazoles; Oxidative Stress; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).
Topics: Animals; Antioxidants; Cell Line; Cells, Cultured; Cytokines; Lippia; Macrophages; Mice; Nitroimidazoles; Oils, Volatile; Oxidative Stress; Plant Oils; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Humans; Inhibitory Concentration 50; Mice; Neglected Diseases; Nifurtimox; Nitro Compounds; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Sulfones | 2021 |
Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon.
Topics: Abdominal Wall; Animals; Brazil; Chagas Disease; Esophagus; Heart; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Stomach; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole.
Topics: Acute Disease; Animals; Antioxidants; Cerebral Cortex; Chagas Disease; Female; Gene Expression; Immunosuppressive Agents; Mice; Nitroimidazoles; Oxidative Stress; Receptors, Purinergic; Resveratrol | 2021 |
Benznidazole in Chagas disease study: do the data justify progression to phase 3?
Topics: Chagas Disease; Humans; Nitroimidazoles | 2021 |
Benznidazole in Chagas disease study: do the data justify progression to phase 3? - Authors' reply.
Topics: Chagas Disease; Humans; Nitroimidazoles | 2021 |
Predictors of development of cardiac and digestive disorders among patients with indeterminate chronic Chagas Disease.
Topics: Adult; Antiprotozoal Agents; Brazil; Chagas Disease; Chronic Disease; Digestive System Diseases; Female; Heart Diseases; Humans; Male; Middle Aged; Nitroimidazoles; Retrospective Studies; Trypanosoma cruzi | 2021 |
HIV and Chagas Disease: An Evaluation of the Use of Real-Time Quantitative Polymerase Chain Reaction to Measure Levels of Trypanosoma cruzi Parasitemia in HIV Patients in Cochabamba, Bolivia.
Topics: Adult; Antibodies, Protozoan; Bolivia; CD4 Lymphocyte Count; Chagas Disease; Coinfection; Cross-Sectional Studies; Female; HIV Infections; Humans; Latent Infection; Male; Microscopy; Middle Aged; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi; Viral Load | 2021 |
Chemiluminescent Microparticle Immunoassay for the Diagnosis of Congenital Chagas Disease: A Prospective Study in Spain.
Topics: Adult; Antibodies, Protozoan; Chagas Disease; Female; Fetal Blood; Fluorescent Antibody Technique, Indirect; Humans; Immunoassay; Infant; Infant, Newborn; Luminescent Measurements; Male; Nitroimidazoles; Prospective Studies; Sensitivity and Specificity; Spain; Trypanocidal Agents; Young Adult | 2021 |
Assessing antibody decline after chemotherapy of early chronic Chagas disease patients.
Topics: Adolescent; Antibodies, Protozoan; Chagas Disease; Chronic Disease; Cohort Studies; Female; Humans; Immunoglobulin G; Immunologic Tests; Male; Molecular Diagnostic Techniques; Nifurtimox; Nitroimidazoles; Pilot Projects; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease.
Topics: Animals; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Docosahexaenoic Acids; Female; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nitroimidazoles; Parasite Load; Receptors, Formyl Peptide; Trypanosoma cruzi | 2021 |
Association of HLA-B∗35 and moderate or severe cutaneous reactions secondary to benznidazole treatment in chronic chagas disease.
Topics: Adult; Chagas Disease; Female; HLA-B Antigens; Humans; Hypersensitivity, Delayed; Male; Middle Aged; Nitroimidazoles; Skin | 2022 |
In Vivo and In Vitro Taste Assessment of Artesunate-Mefloquine, Praziquantel, and Benznidazole Drugs for Neglected Tropical Diseases and Pediatric Patients.
Topics: Animals; Artesunate; Child; Humans; Mefloquine; Nitroimidazoles; Praziquantel; Rats; Tablets; Taste | 2021 |
Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Chagas Cardiomyopathy; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Female; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Morpholines; Myocytes, Cardiac; Nitroimidazoles; Primary Cell Culture; RAW 264.7 Cells | 2021 |
Prodrugs as new therapies against Chagas disease: in vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole.
Topics: Amino Acid Isomerases; Animals; Chagas Disease; Esters; Humans; Mice; Nitroimidazoles; Parasites; Prodrugs; Trypanosoma cruzi | 2022 |
4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.
Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Chagas Disease; Disease Models, Animal; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Modulation of miR-145-5p and miR-146b-5p levels is linked to reduced parasite load in H9C2 Trypanosoma cruzi infected cardiomyoblasts.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Drug Combinations; Gene Expression Regulation; Host-Parasite Interactions; MicroRNAs; Myocytes, Cardiac; Nitroimidazoles; Oligoribonucleotides; Pentoxifylline; Rats; Signal Transduction; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Assessment of a combined treatment with a therapeutic vaccine and benznidazole for the Trypanosoma cruzi chronic infection.
Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Persistent Infection; Trypanocidal Agents; Trypanosoma cruzi; Vaccines | 2022 |
Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease.
Topics: Chagas Disease; Child; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Trypanocidal Agents | 2022 |
Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.
Topics: Amiodarone; Animals; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Heart; Heart Diseases; Heart Function Tests; Humans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanosoma cruzi | 2022 |
Mitigation of benznidazole toxicity and oxidative stress following ascorbic acid supplementation in an adult traveller with chronic indeterminate Chagas' disease.
Topics: Adult; Antioxidants; Ascorbic Acid; Biomarkers; Chagas Disease; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Oxidative Stress | 2022 |
Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs.
Topics: Animals; Chagas Disease; Dogs; Itraconazole; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy.
Topics: Administration, Oral; Biological Availability; Caco-2 Cells; Chagas Disease; Humans; Nanoparticles; Nitroimidazoles; Particle Size; Solubility | 2022 |
Traditional use of benznidazole with weekly clinical follow-up indicate to be an important approach for the etiologic treatment of Chagas disease.
Topics: Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Miltefosine and Benznidazole Combination Improve Anti-
Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Phosphorylcholine; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance.
Topics: Animals; Chagas Disease; Disulfiram; Drug Resistance; Humans; Mice; Nitroimidazoles; Transaminases; Trypanocidal Agents | 2022 |
Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in
Topics: Amiodarone; Chagas Disease; Cytoskeleton; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice.
Topics: Adjuvants, Immunologic; Animals; Chagas Disease; Dogs; Fibrosis; Humans; Inflammation; Mice; Mice, Inbred BALB C; Nitroimidazoles; Perforin; Protozoan Vaccines; Recombinant Proteins; Toll-Like Receptor 4; Trypanosoma cruzi; Vaccines, Combined; Vaccines, DNA | 2022 |
Severe drug-induced liver injury (DILI) associated with benznidazole therapy for Chagas' disease.
Topics: Chagas Cardiomyopathy; Chagas Disease; Chemical and Drug Induced Liver Injury; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi
Topics: Animals; Chagas Disease; Chloroquine; Drug Repositioning; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure.
Topics: Animals; Chagas Disease; Dogs; Humans; Mammals; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Long-term cardiology outcomes in children after early treatment for Chagas disease, an observational study.
Topics: Adult; Cardiology; Chagas Cardiomyopathy; Chagas Disease; Child; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Anti-Trypanosoma cruzi antibody profiling in patients with Chagas disease treated with benznidazole assessed by genome phage display.
Topics: Bacteriophages; Chagas Disease; Epitopes; Humans; Immunoglobulin G; Nitroimidazoles; Trypanosoma cruzi | 2023 |
Effect of B-NIPOx in Experimental
Topics: Animals; Chagas Disease; Isoenzymes; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole.
Topics: Chagas Disease; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Prospective Studies; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Major benznidazole metabolites in patients treated for Chagas disease: Mass spectrometry-based identification, structural analysis and detoxification pathways.
Topics: Chagas Disease; Chromatography, High Pressure Liquid; Humans; Ions; Mass Spectrometry; Nitroimidazoles | 2023 |
A functional assay using human whole blood and flow cytometry analysis to evaluate cytotoxicity and immunomodulatory effect of anti-Trypanosoma cruzi drugs.
Topics: Chagas Disease; Cytokines; Flow Cytometry; Humans; Interleukin-10; Interleukin-8; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Fibrosis; Gene Expression Profiling; Mice; MicroRNAs; Nitroimidazoles; Pentoxifylline; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Trypanosoma cruzi: Does the intake of nanoencapsulated benznidazole control acute infections?
Topics: Animals; Chagas Disease; Female; Mice; Nanocapsules; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Frequency Variation and Dose Modification of Benznidazole Administration for the Treatment of Trypanosoma cruzi Infection in Mice, Dogs, and Nonhuman Primates.
Topics: Animals; Chagas Disease; Clinical Protocols; Dogs; Humans; Mammals; Mice; Nitroimidazoles; Primates; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Benzonidazole treatment has a beneficial effect on cells infected with the Colombian strain of Trypanosoma cruzi.
Topics: Chagas Disease; Colombia; Humans; Leukocytes, Mononuclear; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations.
Topics: Chagas Disease; Gene Expression Profiling; Humans; Nitroimidazoles; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation.
Topics: Adult; Chagas Disease; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitroimidazoles; Polymerase Chain Reaction; Trypanocidal Agents | 2023 |
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole.
Topics: Antiprotozoal Agents; Chagas Disease; Cycloaddition Reaction; Humans; Isoxazoles; Nitroimidazoles; Structure-Activity Relationship; Trypanosoma cruzi | 2023 |
Drug-excipient compatibility studies in formulation development: A case study with benznidazole and monoglycerides.
Topics: Excipients; Glycerides; Monoglycerides; Nitroimidazoles | 2023 |
Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells.
Topics: Adipocytes; Adipose Tissue; Cell Differentiation; Chagas Disease; Humans; Interleukin-6; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease.
Topics: Animals; Chagas Disease; Disease Progression; Heart; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.
Topics: Animals; Chagas Disease; DNA Damage; Mammals; Mice; Nitroimidazoles; Parasites; Trypanocidal Agents; Trypanosoma cruzi | 2023 |