benzofurans and tipifarnib

benzofurans has been researched along with tipifarnib* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and tipifarnib

Article	Year
Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors. Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6 A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC(50)=1.1nM) and antitumor activity in human cancer xenografts in mice. Topics: Animals; Antineoplastic Agents; Benzofurans; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Inhibitory Concentration 50; Mice; Neoplasm Transplantation; Quinolones; Structure-Activity Relationship	2009

Article

Year

Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors.

Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC(50)=1.1nM) and antitumor activity in human cancer xenografts in mice.

Topics: Animals; Antineoplastic Agents; Benzofurans; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Inhibitory Concentration 50; Mice; Neoplasm Transplantation; Quinolones; Structure-Activity Relationship

2009