benzofurans and ramatroban

Thromboxane (TxA. Using isolated organ bath, saphenous vein and internal mammary artery preparations were incubated with TP receptor antagonist, TxS inhibitor, aspirin, IP or EP4 receptor antagonist. Then prostaglandin (PG)E. TP receptor antagonist and TxS inhibitor are more effective to reduce contraction induced by different spasmogens in comparison to aspirin. Our results suggest that TP receptor antagonist and TxS inhibitor might have an advantage over aspirin due to their preventive effect on increased vascular reactivity observed in post-operative period of coronary artery bypass grafting.

Topics: Arachidonic Acid; Aspirin; Benzofurans; Carbazoles; Enzyme Inhibitors; Female; Humans; Male; Mammary Arteries; Muscle, Smooth, Vascular; Phenylephrine; Receptors, Prostaglandin; Receptors, Thromboxane; Saphenous Vein; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction