benzofurans and pyronaridine

benzofurans has been researched along with pyronaridine* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and pyronaridine

Article	Year
[[1]Benzofuro[3,2-b]pyridin-4-yl-amines - synthesis and investigation of activity against malaria]. Die Pharmazie, 2004, Volume: 59, Issue:6 The ethyl 4-chlorobenzofuro[3,2-b]pyridine-3-carboxylate (2) reacted with the hydrochlorides of the mono- and bis-phenol Mannich bases 3 to yield the amodiaquine and pyronaridine analogues 4. The chloroquine analogue 6 was formed by melting 2 with the novaldiamine base (5) in phenol. The most active compound 4c inhibited the growth of the malaria parasite Plasmodium falciparum with an IC50 of 500 nM. Topics: Amines; Amodiaquine; Animals; Antimalarials; Benzofurans; Chemical Phenomena; Chemistry, Physical; Mannich Bases; Naphthyridines; Plasmodium falciparum	2004

Article

Year

[[1]Benzofuro[3,2-b]pyridin-4-yl-amines - synthesis and investigation of activity against malaria].

Die Pharmazie, 2004, Volume: 59, Issue:6

The ethyl 4-chlorobenzofuro[3,2-b]pyridine-3-carboxylate (2) reacted with the hydrochlorides of the mono- and bis-phenol Mannich bases 3 to yield the amodiaquine and pyronaridine analogues 4. The chloroquine analogue 6 was formed by melting 2 with the novaldiamine base (5) in phenol. The most active compound 4c inhibited the growth of the malaria parasite Plasmodium falciparum with an IC50 of 500 nM.

Topics: Amines; Amodiaquine; Animals; Antimalarials; Benzofurans; Chemical Phenomena; Chemistry, Physical; Mannich Bases; Naphthyridines; Plasmodium falciparum

2004