benzofurans and pyrimidine

benzofurans has been researched along with pyrimidine* in 2 studies

Other Studies

2 other study(ies) available for benzofurans and pyrimidine

ArticleYear
P2Y14R for inflammation therapy: is it a promising target?
    Future medicinal chemistry, 2021, Volume: 13, Issue:18

    Topics: Anti-Inflammatory Agents; Benzofurans; Benzoic Acid; Biomarkers; Drug Evaluation, Preclinical; Humans; Inflammation; Naphthalenes; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Structure-Activity Relationship; Triazoles

2021
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
    Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15

    Introduction of nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzofuran inhibitor 2, resulted in the discovery of the more potent pyridofuran analogue 5. Subsequent introduction of small alkyl and alkoxy ligands into the pyridine ring resulted in further improvements in replicon potency. Replacement of the 4-chloro moiety on the pyrimidine core with a methyl group, and concomitant monoalkylation of the C-2 amino moiety resulted in the identification of several inhibitors with desirable characteristics. Inhibitor 41, from the monosubstituted pyridofuran and inhibitor 50 from the disubstituted series displayed excellent potency, selectivity (GAPDH/MTS CC(50)) and PK parameters in all species studied, while the selectivity in the thymidine incorporation assay (DNA·CC(50)) was low.

    Topics: Animals; Antiviral Agents; Benzofurans; Enzyme Inhibitors; Furans; Half-Life; Hepacivirus; Liver; Pyrimidine Nucleosides; Pyrimidines; Rats; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Virus Replication

2012
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