benzofurans and pyrimidine
benzofurans has been researched along with pyrimidine* in 2 studies
Other Studies
2 other study(ies) available for benzofurans and pyrimidine
Article | Year |
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P2Y14R for inflammation therapy: is it a promising target?
Topics: Anti-Inflammatory Agents; Benzofurans; Benzoic Acid; Biomarkers; Drug Evaluation, Preclinical; Humans; Inflammation; Naphthalenes; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Structure-Activity Relationship; Triazoles | 2021 |
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Introduction of nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzofuran inhibitor 2, resulted in the discovery of the more potent pyridofuran analogue 5. Subsequent introduction of small alkyl and alkoxy ligands into the pyridine ring resulted in further improvements in replicon potency. Replacement of the 4-chloro moiety on the pyrimidine core with a methyl group, and concomitant monoalkylation of the C-2 amino moiety resulted in the identification of several inhibitors with desirable characteristics. Inhibitor 41, from the monosubstituted pyridofuran and inhibitor 50 from the disubstituted series displayed excellent potency, selectivity (GAPDH/MTS CC(50)) and PK parameters in all species studied, while the selectivity in the thymidine incorporation assay (DNA·CC(50)) was low. Topics: Animals; Antiviral Agents; Benzofurans; Enzyme Inhibitors; Furans; Half-Life; Hepacivirus; Liver; Pyrimidine Nucleosides; Pyrimidines; Rats; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Virus Replication | 2012 |