benzofurans and orcinol

benzofurans has been researched along with orcinol* in 4 studies

Other Studies

4 other study(ies) available for benzofurans and orcinol

ArticleYear
Are atranols the only skin sensitizers in oakmoss? A systematic investigation using non-animal methods.
    Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 70

    Oakmoss and treemoss absolutes are the major natural extracts of concern as potential sources of skin sensitizers in cosmetics and personal care products (PCP). Two single constituents, atranol and chloroatranol, have been identified as primary culprits in both lichens, and industrial self-regulation has been proposed to limit their contents to less than 100 ppm. Nonetheless, evidence points to the presence of additional candidate skin sensitizers in these multicomponent extracts. These observations, along with a lack of data from non-animal alternative methods and the chemical variability of commercial absolutes, prompted further investigation of oakmoss absolute along with altranol-like compounds in these extracts. The major chemical constituents of a commercial sample were identified by two independent analytical techniques, GC-MS and HPLC-DAD-MS. The crude oakmoss extract and pure compounds were assayed with two in chemico methods (HTS-DCYA and DPRA) to gauge their chemical reactivity. Activation of inflammatory responses in vitro was also investigated by KeratinoSens™ and human cell line activation tests (h-CLAT). Based on weight of evidence, orcinol, ethyl orsellinate, and usnic acid were classified as candidate sensitizers, along with both atranols and oakmoss extract.

    Topics: Animal Testing Alternatives; Benzaldehydes; Benzofurans; Cell Line; Haptens; Humans; Resins, Plant; Resorcinols; Terpenes

2021
Constituents of Ramalina capitata (Ach.) Nyl. extracts.
    Natural product research, 2017, Volume: 31, Issue:7

    The aim of this work was to determine the chemical composition of the ether, ethyl acetate and dichloromethane extracts of Ramalina capitata by GC-FID and GC-MS for the first time. The main identified components in the ether, ethyl acetate and dichloromethane extracts were everninic acid (24.7, 33.7 and 22.2%), orcinol (25.8, 16.7 and 11.9%), orcinol monomethyl ether (11.6, 7.6 and 4.8%), 3-methylorsellinic acid (10.2, 7.1 and 9.0%) and usnic acid (4.4, 8.2 and 25.8%), respectively. Considerable amount (10.4%) of 2-hydroxy-4-methoxy-3,5,6-trimethylbenzoic acid was detected in ethyl acetate extract. Additionally, palmitic acid, linoleic acid, oleic acid and stearic acid and their esters were observed in the dichloromethane and ethyl acetate extracts in the range of 4.1-0.1%, while their amount was below 0.05% in the ether extract. According to the results reported here R. capitata predominantly biosynthesises derivatives of orcinol and, in much lesser extent, derivatives of β-orcinol.

    Topics: Ascomycota; Benzofurans; Chromatography, Gas; Flame Ionization; Gas Chromatography-Mass Spectrometry; Methanol; Resorcinols; Solvents

2017
[Study on the chemical constituents of two lichen plants from Meng Mountain].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2013, Volume: 36, Issue:9

    To investigate the chemical constituents of the lichen plants Parmelia tinctorum and Parmelia nimandairana collected from Meng Mountain in Shandong province.. Various chromatographic techniques were used to isolate and purify the constituents and their structures were elucidated by means of spectral evidence and physiochemical properties.. Four compounds were isolated from Parmelia tinctorum and identified as: lecanoric acid (I), evernic acid (II), ethyl orsellinate (III) and 3,5-dihydroxytoluene (IV). Two compounds were isolated from Parmelia nimandairana and identified as: usnic acid (V) and salazinic acid (VI).. Compounds V and VI are isolated from Parmelia nimandairana for the first time.

    Topics: Benzofurans; China; Chromatography, High Pressure Liquid; Hydroxybenzoates; Lactones; Lichens; Molecular Structure; Resorcinols; Salicylates; Solvents

2013
Molecular structural studies of lichen substances with antimicrobial, antiproliferative, and cytotoxic effects from Parmelia subrudecta.
    Preparative biochemistry & biotechnology, 2010, Volume: 40, Issue:4

    Lecanoric acid (1), orsellinic acid methyl ester (2), orcinol (3), and usnic acid (4) were isolated from the lichen Parmelia subrudecta, collected on Palma of the Canary Islands, Spain. Compounds 1, 2, 3, and 4 were purified by solvent extraction, silica gel column chromatography, and preparative high-performance liquid chromatography (HPLC) consecutively. The structures of the four compounds were elucidated by one- and two-dimensional nuclear magnetic resonance (NMR) experiments and mass spectrometric investigations. These compounds showed activity against important gram-positive and gram-negative pathogens like mycobacteria and multiresistant staphylococci. This activity is combined with antiproliferative activity and cytotoxicity.

    Topics: Anti-Infective Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Benzofurans; Cell Line, Tumor; Cell Proliferation; Humans; Lichens; Magnetic Resonance Spectroscopy; Molecular Structure; Neoplasms; Resorcinols; Salicylates; Spectrometry, Mass, Electrospray Ionization

2010