benzofurans and echinacoside

benzofurans has been researched along with echinacoside* in 2 studies

Other Studies

2 other study(ies) available for benzofurans and echinacoside

Article	Year
The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model. Phytotherapy research : PTR, 2018, Volume: 32, Issue:3 Efficient transcytosis across the blood-brain-barrier is an important strategy for accessing drug targets within the central nervous system. Ligusticum chuanxiong Hort. was used as a messenger drug to increase the distribution of drugs in brain tissue in Traditional Chinese Medicine. The present study investigates the transport of echinacoside (ECH) through MDCK-MDR1 cell and the effects of ligustilide (LIG), senkyunolide A (SENA) and senkyunolide I (SENI) in chuanxiong on its transport. The results indicated that the absorption of ECH was relatively poor in MDCK-MDR1cells, and was concentration dependent and not saturable. The P-glycoprotein inhibitor verapamil could significantly increase the transport of ECH. It indicated that the transport mechanism might be passive diffusion as the dominating process with the active transportation mediated mechanism involved. The increased apparent permeability of ECH in A → B direction by ethylenediaminetetraacetic acid-Na Topics: 4-Butyrolactone; Animals; Benzofurans; Biological Transport; Blood-Brain Barrier; Dogs; Drugs, Chinese Herbal; Glycosides; Humans; Madin Darby Canine Kidney Cells	2018
Interactions of Bovine Serum Albumin with Anti-Cancer Compounds Using a ProteOn XPR36 Array Biosensor and Molecular Docking. Molecules (Basel, Switzerland), 2016, Dec-10, Volume: 21, Issue:12 The aim of the work was to determine the interactions of a set of anti-cancer compounds with bovine serum albumin (BSA) using a ProteOn XPR36 array biosensor and molecular docking studies. The results revealed that a total of six anti-cancer compounds: gallic acid, doxorubicin, acteoside, salvianolic acid B, echinacoside, and vincristine were able to reversibly bind to the immobilized BSA. The sensorgrams of these six compounds were globally fit to a Langmuir 1:1 interaction model for binding kinetics analysis. There were significant differences in their affinity for BSA, with doxorubicin, the weakest binding compound having 1000-fold less affinity than salvianolic acid B, the strongest binding compound. However, compounds with a similar KD often exhibited markedly different kinetics due to the differences in Topics: Animals; Antineoplastic Agents; Benzofurans; Binding Sites; Biosensing Techniques; Cattle; Doxorubicin; Gallic Acid; Glucosides; Glycosides; Molecular Docking Simulation; Phenols; Protein Array Analysis; Protein Binding; Serum Albumin, Bovine; Surface Plasmon Resonance; Vincristine	2016

Article

Year

The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model.

Phytotherapy research : PTR, 2018, Volume: 32, Issue:3

Efficient transcytosis across the blood-brain-barrier is an important strategy for accessing drug targets within the central nervous system. Ligusticum chuanxiong Hort. was used as a messenger drug to increase the distribution of drugs in brain tissue in Traditional Chinese Medicine. The present study investigates the transport of echinacoside (ECH) through MDCK-MDR1 cell and the effects of ligustilide (LIG), senkyunolide A (SENA) and senkyunolide I (SENI) in chuanxiong on its transport. The results indicated that the absorption of ECH was relatively poor in MDCK-MDR1cells, and was concentration dependent and not saturable. The P-glycoprotein inhibitor verapamil could significantly increase the transport of ECH. It indicated that the transport mechanism might be passive diffusion as the dominating process with the active transportation mediated mechanism involved. The increased apparent permeability of ECH in A → B direction by ethylenediaminetetraacetic acid-Na

Topics: 4-Butyrolactone; Animals; Benzofurans; Biological Transport; Blood-Brain Barrier; Dogs; Drugs, Chinese Herbal; Glycosides; Humans; Madin Darby Canine Kidney Cells

2018

Interactions of Bovine Serum Albumin with Anti-Cancer Compounds Using a ProteOn XPR36 Array Biosensor and Molecular Docking.

Molecules (Basel, Switzerland), 2016, Dec-10, Volume: 21, Issue:12

The aim of the work was to determine the interactions of a set of anti-cancer compounds with bovine serum albumin (BSA) using a ProteOn XPR36 array biosensor and molecular docking studies. The results revealed that a total of six anti-cancer compounds: gallic acid, doxorubicin, acteoside, salvianolic acid B, echinacoside, and vincristine were able to reversibly bind to the immobilized BSA. The sensorgrams of these six compounds were globally fit to a Langmuir 1:1 interaction model for binding kinetics analysis. There were significant differences in their affinity for BSA, with doxorubicin, the weakest binding compound having 1000-fold less affinity than salvianolic acid B, the strongest binding compound. However, compounds with a similar KD often exhibited markedly different kinetics due to the differences in

Topics: Animals; Antineoplastic Agents; Benzofurans; Binding Sites; Biosensing Techniques; Cattle; Doxorubicin; Gallic Acid; Glucosides; Glycosides; Molecular Docking Simulation; Phenols; Protein Array Analysis; Protein Binding; Serum Albumin, Bovine; Surface Plasmon Resonance; Vincristine

2016