benzofurans and cyclopropanecarboxylic-acid

benzofurans has been researched along with cyclopropanecarboxylic-acid* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and cyclopropanecarboxylic-acid

Article	Year
Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 In a search for novel small molecule calcium-sensing receptor (CaSR) antagonists as oral bone anabolic agents, we discovered dihydrobenzofuran cyclopropane carboxylic acid derivatives, such as 12f (IC50=27.6nM), are highly potent calcium-sensing receptor antagonists. Studies in rats established that compound 12f stimulates parathyroid hormone (PTH) release in a fast-acting, pulsatile manner. Topics: Administration, Oral; Animals; Benzofurans; Cyclopropanes; Drug Evaluation, Preclinical; Female; Half-Life; Osteoporosis; Parathyroid Hormone; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Structure-Activity Relationship	2016

Article

Year

Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis.

Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

In a search for novel small molecule calcium-sensing receptor (CaSR) antagonists as oral bone anabolic agents, we discovered dihydrobenzofuran cyclopropane carboxylic acid derivatives, such as 12f (IC50=27.6nM), are highly potent calcium-sensing receptor antagonists. Studies in rats established that compound 12f stimulates parathyroid hormone (PTH) release in a fast-acting, pulsatile manner.

Topics: Administration, Oral; Animals; Benzofurans; Cyclopropanes; Drug Evaluation, Preclinical; Female; Half-Life; Osteoporosis; Parathyroid Hormone; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Structure-Activity Relationship

2016