benzofurans has been researched along with cleistanthin* in 1 studies
1 other study(ies) available for benzofurans and cleistanthin
| Article | Year |
|---|---|
Synthesis and identification of cytotoxic diphyllin glycosides as vacuolar H(+)-ATPase inhibitors.
The concise syntheses of two natural diphyllin glycosides Cleistanthin-A (CA), Cleistanthoside-A (CleA) and its derivative, Cleistanthoside-A tetraacetate (CleT), have been achieved. They were evaluated for their in vitro anti-proliferative activities against MCF-7, HeLa, HepG2, HCT-116, U251 cancer cell lines by MTT assay. Both of CA and CleT were anti-proliferative to these cancer cells at nanomolar concentrations. They have been shown to inhibit the activity of vacuolar H(+)-ATPase (V-ATPase) in HepG2 cells and neutralize the pH of lysosomes at nanomolar concentrations. Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Cell Proliferation; Disaccharides; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Glycosides; HCT116 Cells; HeLa Cells; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Lignans; Lysosomes; MCF-7 Cells; Molecular Conformation; Structure-Activity Relationship; Vacuolar Proton-Translocating ATPases | 2014 |