benzofurans has been researched along with ciglitazone* in 1 studies
1 other study(ies) available for benzofurans and ciglitazone
| Article | Year |
|---|---|
Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.
The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg. Topics: 3T3 Cells; Adipocytes; Animals; Benzofurans; Carboxylic Acids; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Mice; Mice, Mutant Strains; Mice, Obese; Molecular Structure; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1996 |