benzofurans has been researched along with carmoxirole* in 1 studies
1 other study(ies) available for benzofurans and carmoxirole
| Article | Year |
|---|---|
A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone.
A major metabolite of the potential antidepressant vilazodone formed in rat, dog, monkey and human liver microsomes is the 5-cyano-6-hydroxy-1H-indole derivative. For the construction of the salicyl-like substituted indole we adapted a synthesis of carmoxirole using Japp-Klingemann type Fischer-indole synthesis protocols. Functional group interconversion of carboxylic acid via carboxamide into cyanide was performed with methanesulfonic acid chloride. Topics: Antidepressive Agents; Benzofurans; Carboxylic Acids; Humans; Hydroxylation; Indoles; Piperazines; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Vilazodone Hydrochloride | 2004 |