benzofurans and benzofurocaine

In the process of treatment of experimental close fractures of radius in rats by intramuscular administration of benzofurocaine (60 mg/kg), the regeneration processes of the bone tissue were activated to a greater degree than in case of administration of etadene (20 mg/kg) or xanthinol nicotinate (30 mg/kg). Under the influence of benzofurocaine, beginning on the 10-20-th day of the experiment, there have been noted the reorganization of young callus into the mature laminal bone. The preparations of comparison have demonstrated less expressed analogous action.

Topics: Adenine; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Bone Regeneration; Female; Injections, Intramuscular; Male; Radiation-Protective Agents; Radius Fractures; Rats; Xanthinol Niacinate

A native non-narcotic analgetic agent benzofurcaine was used in 51 patients. It was shown that the analgetic activity of benzofurocaine had a dose-dependent character. Most effective was its use in doses of 2.1-2.7 mg/kg of body weight. It was established that the character of hemodynamic reactions due to benzofurocaine depended on the initial state of circulation. Benzofurocaine did not depress breathing. It is concluded that benzofuricaine is an effective means in moderate pain syndrome due to residual pain as well as in pain of pericardial genesis.

Topics: Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Local; Benzofurans; Drug Evaluation; Hemodynamics; Humans; Middle Aged; Myocardial Infarction; Respiration

Topics: Anesthetics, Local; Animals; Benzofurans; Drug Evaluation, Preclinical; Heart; Myocardial Infarction; Myocardium; Periodic Acid-Schiff Reaction; Rabbits; Time Factors

Topics: Anesthetics, Local; Animals; Benzofurans; Cardiovascular Agents; Cats; Myocardial Infarction

Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthetics, Local; Benzofurans; Humans; Middle Aged; Surgical Procedures, Operative