benzofurans has been researched along with alternariol* in 2 studies
1 review(s) available for benzofurans and alternariol
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Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick.
Covering: 1893 to 2017Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given. Topics: Benzofurans; Biological Products; Citrinin; Emodin; Fungi; Griseofulvin; History, 20th Century; Humans; Lactones; Mycophenolic Acid; Zearalenone | 2018 |
1 other study(ies) available for benzofurans and alternariol
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New antitumour fungal metabolites from Alternaria porri.
Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1). Topics: Alternaria; Anthraquinones; Antineoplastic Agents; Benzofurans; Colorimetry; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Inhibitory Concentration 50; KB Cells; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Phthalic Acids | 2009 |