benzofurans and 8-8--bieckol

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases with a multifactorial nature. β-Secretase (BACE1) and acetylcholinesterase (AChE), which are required for the production of neurotoxic β-amyloid (Aβ) and the promotion of Aβ fibril formation, respectively, are considered as prime therapeutic targets for AD. In our efforts towards the development of potent multi-target, directed agents for AD treatment, major phlorotannins such as eckol, dieckol, and 8,8'-bieckol from

Topics: ADAM17 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Benzofurans; Cholinesterase Inhibitors; Cholinesterases; Dioxins; Molecular Docking Simulation; Seaweed; Tannins

Alzheimer disease (AD) is a neurodegenerative disorder characterized by excessive accumulation of amyloid-beta peptide (Aβ) and progressive loss of neurons. Therefore, the inhibition of Aβ-induced neurotoxicity is a potential therapeutic approach for the treatment of AD.

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; Cyclooxygenase 2; Dioxins; Down-Regulation; Drug Evaluation, Preclinical; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; PC12 Cells; Peptide Fragments; Phaeophyceae; Rats; Seaweed