benzofurans and 4-dimethylaminopyridine

benzofurans has been researched along with 4-dimethylaminopyridine* in 2 studies

Other Studies

2 other study(ies) available for benzofurans and 4-dimethylaminopyridine

Article	Year
Synthesis of 3-aryl-2-arylamidobenzofurans based on the Curtius rearrangement. The Journal of organic chemistry, 2011, Apr-15, Volume: 76, Issue:8 The synthesis of novel 3-aryl-2-arylamidobenzofurans has been accomplished via a Curtius rearrangement strategy in four steps from benzofuran-2-carboxylic acids. The requisite Suzuki-Miyaura cross-coupling, with benzyl 3-bromobenzofuran-2-ylcarbamate or 2-arylamido-3-bromobenzofurans, revealed an unusual reductive debromination process due to the presence of the free NH group. This dehalogenation can be suppressed by N-alkylation. DMAP is an efficient reagent for the one-pot conversion of benzyl benzofuran-2-ylcarbamates into the corresponding benzofuran-2-arylamides through aroylation, thus acting both as an acyl transfer reagent and a deprotecting agent of the Cbz group. A mechanism is postulated. Topics: 4-Aminopyridine; Alkylation; Amides; Amines; Benzofurans; Biological Products; Boronic Acids; Carboxylic Acids; Catalysis; Chemistry, Pharmaceutical; Stereoisomerism	2011
(1)H and DOSY NMR spectroscopy analysis of Ligusticum porteri rhizome extracts. Magnetic resonance in chemistry : MRC, 2011, Volume: 49, Issue:8 The presence of dimeric phthalides and other constituents in extracts of the vegetal species Ligusticum porteri was established by NMR spectroscopy. In comparative qualitative (1)H NMR analyses of acetone extracts of rhizomes from fresh and dried L. porteri samples, we found that the dimeric phthalides tokinolide B (3), diligustilide (4) and riligustilide (5) were naturally produced by the plant and not post-harvest products. We also obtained DOSY (1)H NMR data that provided both virtual separation and structural information for the phthalides present in a dry acetone extract of L. porteri. In addition, we developed a protocol for the quantification of dimeric phthalides, which is performed by calculating the relative ratio of the peak area of selected proton signals for some compounds with respect to the known signal of the internal standard, 4-dimethylaminopyridine. The protocol allows the rapid and direct quantification of dimeric phthalides and others constituents in fresh L. porteri rhizomes. Topics: 4-Aminopyridine; Acetone; Benzofurans; Ligusticum; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts; Protons; Reference Standards; Rhizome; Solvents	2011

Article

Year

Synthesis of 3-aryl-2-arylamidobenzofurans based on the Curtius rearrangement.

The Journal of organic chemistry, 2011, Apr-15, Volume: 76, Issue:8

The synthesis of novel 3-aryl-2-arylamidobenzofurans has been accomplished via a Curtius rearrangement strategy in four steps from benzofuran-2-carboxylic acids. The requisite Suzuki-Miyaura cross-coupling, with benzyl 3-bromobenzofuran-2-ylcarbamate or 2-arylamido-3-bromobenzofurans, revealed an unusual reductive debromination process due to the presence of the free NH group. This dehalogenation can be suppressed by N-alkylation. DMAP is an efficient reagent for the one-pot conversion of benzyl benzofuran-2-ylcarbamates into the corresponding benzofuran-2-arylamides through aroylation, thus acting both as an acyl transfer reagent and a deprotecting agent of the Cbz group. A mechanism is postulated.

Topics: 4-Aminopyridine; Alkylation; Amides; Amines; Benzofurans; Biological Products; Boronic Acids; Carboxylic Acids; Catalysis; Chemistry, Pharmaceutical; Stereoisomerism

2011

(1)H and DOSY NMR spectroscopy analysis of Ligusticum porteri rhizome extracts.

Magnetic resonance in chemistry : MRC, 2011, Volume: 49, Issue:8

The presence of dimeric phthalides and other constituents in extracts of the vegetal species Ligusticum porteri was established by NMR spectroscopy. In comparative qualitative (1)H NMR analyses of acetone extracts of rhizomes from fresh and dried L. porteri samples, we found that the dimeric phthalides tokinolide B (3), diligustilide (4) and riligustilide (5) were naturally produced by the plant and not post-harvest products. We also obtained DOSY (1)H NMR data that provided both virtual separation and structural information for the phthalides present in a dry acetone extract of L. porteri. In addition, we developed a protocol for the quantification of dimeric phthalides, which is performed by calculating the relative ratio of the peak area of selected proton signals for some compounds with respect to the known signal of the internal standard, 4-dimethylaminopyridine. The protocol allows the rapid and direct quantification of dimeric phthalides and others constituents in fresh L. porteri rhizomes.

Topics: 4-Aminopyridine; Acetone; Benzofurans; Ligusticum; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts; Protons; Reference Standards; Rhizome; Solvents

2011