benzofurans and 4-aminoquinazoline

benzofurans has been researched along with 4-aminoquinazoline* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and 4-aminoquinazoline

Article	Year
Benzofuran-appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies. Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1 A series of 2-arylbenzo[b]furan-appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (HeLa) cell lines. Compounds 10d and 10j exhibited significant cytotoxicity against the C3A and Caco-2 cell lines and induced apoptosis in these cell lines. Likewise, compounds 10d and 10e exhibited significant inhibitory activity towards epidermal growth factor receptor-tyrosine kinase phosphorylation (IC Topics: Adenosine Triphosphate; Apoptosis; Benzofurans; Binding Sites; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Proton Magnetic Resonance Spectroscopy; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship	2018

Article

Year

Benzofuran-appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies.

Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

A series of 2-arylbenzo[b]furan-appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (HeLa) cell lines. Compounds 10d and 10j exhibited significant cytotoxicity against the C3A and Caco-2 cell lines and induced apoptosis in these cell lines. Likewise, compounds 10d and 10e exhibited significant inhibitory activity towards epidermal growth factor receptor-tyrosine kinase phosphorylation (IC

Topics: Adenosine Triphosphate; Apoptosis; Benzofurans; Binding Sites; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Proton Magnetic Resonance Spectroscopy; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

2018