benzofurans and 2-acetylbenzofuran

Inhibition of α-glucosidase is one of the important approaches in designing antidiabetic drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase in blood sugar levels in diabetic patients. In the present study we designed a novel series of 2-acetylbenzofuran hydrazones (L1-L7) and their metal (II) complexes Cu (II), Co (II), Zn (II) and Mn (II) (8-29) and screened for inhibitory activity against the yeast α-glucosidase. The synthesis of hydrazones incorporated the use of I

Topics: alpha-Glucosidases; Benzofurans; Coordination Complexes; Dose-Response Relationship, Drug; Glycoside Hydrolase Inhibitors; Humans; Hydrazones; Metals, Heavy; Molecular Structure; Structure-Activity Relationship

We have developed a fluorogenic NAD(P)(+) detection method using 2-acetylbenzofuran. The reaction of NAD(P)(+) with 2-acetylbenzofuran produced a fluorescent product, allowing the highly-sensitive and quick detection of NAD(P)(+). This method was successfully applied to the detection of P450 substrates in the microtiter-plate format.

Topics: Bacterial Proteins; Benzofurans; Camphor 5-Monooxygenase; Cytochrome P-450 Enzyme System; Fluorescent Dyes; Ketones; NADP; NADPH-Ferrihemoprotein Reductase

Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Benzofurans; Drug Design; Enzyme Inhibitors; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Proteins