benzofurans and 2-5-dimethylpyrrole

benzofurans has been researched along with 2-5-dimethylpyrrole* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and 2-5-dimethylpyrrole

Article	Year
A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans. Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3 2-aminoethylbenzofurans constitute a new class of H(3) antagonists that are more rotationally constrained than most previously reported H(3) antagonists. They retain high potency at human and rat receptors, with efficient CNS penetration observed in 35. The SAR of the basic amine moiety was compared in three different series of analogues. The greatest potency was found in analogues bearing a 2-methylpyrrolidine, a 2,5-dimethylpyrrolidine, or a 2,6-dimethylpiperidine. Topics: Amines; Animals; Benzofurans; Central Nervous System; Histamine Antagonists; Humans; Imidazoles; Molecular Structure; Piperidines; Pyrroles; Pyrrolidines; Rats; Receptors, Histamine H3; Structure-Activity Relationship	2004

Article

Year

A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.

Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3

2-aminoethylbenzofurans constitute a new class of H(3) antagonists that are more rotationally constrained than most previously reported H(3) antagonists. They retain high potency at human and rat receptors, with efficient CNS penetration observed in 35. The SAR of the basic amine moiety was compared in three different series of analogues. The greatest potency was found in analogues bearing a 2-methylpyrrolidine, a 2,5-dimethylpyrrolidine, or a 2,6-dimethylpiperidine.

Topics: Amines; Animals; Benzofurans; Central Nervous System; Histamine Antagonists; Humans; Imidazoles; Molecular Structure; Piperidines; Pyrroles; Pyrrolidines; Rats; Receptors, Histamine H3; Structure-Activity Relationship

2004