benzofurans and 1-(2-6-dimethylphenoxy)-2-(3-4-dimethoxyphenylethylamino)propane

benzofurans has been researched along with 1-(2-6-dimethylphenoxy)-2-(3-4-dimethoxyphenylethylamino)propane* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and 1-(2-6-dimethylphenoxy)-2-(3-4-dimethoxyphenylethylamino)propane

Article	Year
Synthesis and blocking activities of isoindolinone- and isobenzofuranone-containing phenoxylalkylamines as potent α(1)-adrenoceptor antagonists. Chemical & pharmaceutical bulletin, 2011, Volume: 59, Issue:1 This paper describes the synthesis and blocking activities of twelve new isoindolinone- and isobenzofuranone-containing phenoxylalkylamines as potent α(1)-Adrenoceptor antagonists. These compounds were synthesized in moderate to good yields starting from 3,4-dimethylphenol, and characterized with (1)H-NMR, MS, IR and elemental analysis. Their blocking activities toward α(1)-Adrenoceptors were evaluated on isolated rat anococcygeus muscles. The results indicated that these compounds were very strong in blocking α(1)-Adrenoceptors, and most of them exhibited activities that were comparable to that of known potent α(1)-Adrenoceptor antagonist 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane hydrochloride (DDPH). Topics: Adrenergic alpha-1 Receptor Antagonists; Amines; Animals; Benzofurans; Isoindoles; Muscles; Phenethylamines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship	2011

Article

Year

Synthesis and blocking activities of isoindolinone- and isobenzofuranone-containing phenoxylalkylamines as potent α(1)-adrenoceptor antagonists.

Chemical & pharmaceutical bulletin, 2011, Volume: 59, Issue:1

This paper describes the synthesis and blocking activities of twelve new isoindolinone- and isobenzofuranone-containing phenoxylalkylamines as potent α(1)-Adrenoceptor antagonists. These compounds were synthesized in moderate to good yields starting from 3,4-dimethylphenol, and characterized with (1)H-NMR, MS, IR and elemental analysis. Their blocking activities toward α(1)-Adrenoceptors were evaluated on isolated rat anococcygeus muscles. The results indicated that these compounds were very strong in blocking α(1)-Adrenoceptors, and most of them exhibited activities that were comparable to that of known potent α(1)-Adrenoceptor antagonist 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane hydrochloride (DDPH).

Topics: Adrenergic alpha-1 Receptor Antagonists; Amines; Animals; Benzofurans; Isoindoles; Muscles; Phenethylamines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship

2011