Compounds > benzo(a)pyrene 7,8-dihydrodiol
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benzo(a)pyrene 7,8-dihydrodiol and benzo(a)pyrene

benzo(a)pyrene 7,8-dihydrodiol has been researched along with benzo(a)pyrene in 80 studies

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199043 (53.75)18.7374
1990's25 (31.25)18.2507
2000's9 (11.25)29.6817
2010's3 (3.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dikun, PP; Filatov, VN; Likhachev, AIa; Savochkina, IV; Tyndyk, ML; Zabezhinskiĭ, MA1
Beniashvili, DSh; Bykov, VJ; Dikun, PP; Likhachev, AJ; Savochkina, IV; Tyndyk, ML; Yermilov, VB; Zabezhinski, MA1
Byczkowski, JZ; Kulkarni, AP1
Bhattacharya, RK; Goswami, UC; Shah, GM1
Eling, TE; Foureman, GL; Knecht, KT1
Doehmer, J; Dogra, S; Friedberg, T; Glatt, H; Mölders, H; Oesch, F; Seidel, A; Siegert, P1
Bartley, JC; Levine, GA; Tischler, AN1
Altman, AH; Boyle, SM; Cromer, EA; James, MO; Schell, JD1
Agarwal, R; Khan, IU; Medrano, EE; Mukhtar, H; Nordlund, JJ1
Sikka, HC; Steward, AR; Zaleski, J2
Strother, A; Teel, RW; Vance, RE1
Dikun, PP; Iamshanov, VA; Likhachev, AIa; Savochkina, IV; Zabezhinskiĭ, MA1
Espino, PC; Sullivan, PD1
Peterson, H; Sevanian, A1
Dankovic, DA; Later, DW; Springer, DL; Thomas, BL; Zangar, RC1
Ball, SS; Mickey, MR; Neshat, MS; Walford, RL1
Alexandrov, K; Rojas, M1
Christou, M; Jefcoate, CR; Keller, GM; Pottenger, LH; Wilson, NM1
Bagheri, K; Hecht, SS; Melikian, AA1
Baird, WM; Harvey, RG; Lee, H; Morgan, SL; Moynihan, CG; Smolarek, TA1
Alexandrov, K; Rojas, M; Sala, M1
Chen, FM; Ransom, S; Woodberry, R1
Babcock, MS; Dixit, R; Stoner, GD; Teel, RW1
Reed, GA1
Glatt, H; Hirom, P; Kirkby, C; Oesch, F; Ribeiro, O; Seidel, A1
Haglund, R; Uziel, M1
Grover, PL; Hall, M1
Hsie, AW; Recio, L1
Michalopoulos, G; Monteith, DK; Novotny, A; Strom, SC1
Le Eberhart, BT; Nishimoto, M; Reichert, WL; Varanasi, U1
Bickers, DR; Das, M; Kaufmann, I; Merk, HF; Mukhtar, H1
Bücker, M; Glatt, H; Oesch, F; Platt, KL1
Krolewski, B; Little, JB1
Abramovich, M; Harvey, RG; Lebreton, PR; Prakash, AS; Zegar, IS2
Baird, WM; Pruess-Schwartz, D1
Nishimoto, M; Varanasi, U1
DeMarco, GJ; McCoy, GD1
Gielen, JE; Nebert, DW; Van Cantfort, J1
Daniel, FB; Dixit, R; Stoner, GD; Teel, RW1
Karamysheva, AF; Kobliakov, VA; Sergeev, BL1
Baird, WM; Smolarek, TA1
Yagi, M1
Wang, IY1
Marnett, LJ1
Nichols, AV; Shu, HP1
Hosomi, J; Kuroki, T; Munakata, K; Nemoto, N; Onizuka, T; Terauchi, M1
Christodoulides, L; Hesse, S; Jernström, B; Ketterer, B; Martinez, M; Moldéus, P1
Jefcoate, CR; Keller, GM; Turner, CR1
Braselton, WE; Roth, RA; Wiersma, DA1
Dix, TA; Marnett, LJ1
Dijkstra, AC; Hukkelhoven, MW; Vermorken, AJ1
Jenssen, D; Romert, L1
Jerina, DM; Mattison, DR; Takizawa, K; Yagi, H1
Eling, TE; Krauss, RS1
Fujita, I; Kikkawa, Y; Rasmussen, RE; Sindhu, RK; Yamamoto, R1
Crespi, CL; Gelboin, HV; Gonzalez, FJ; Korzekwa, KR; Shou, M1
Doehmer, J; Jensen, KG; Loft, S; Onfelt, A; Poulsen, HE1
Borlakoglu, JT; Pangrekar, J; Scott, A; Sikka, HC; Wolf, CR1
Beniashvili, DSh; Bykov, VJ; Kazanova, OI; Likhachev, AJ; Loktionova, NA; Tyndyk, ML; Yatsuk, OS; Yermilov, VB; Zabezhinski, MA1
Kiefer, F; Reen, RK; Roesch, SF; Singh, J; Wiebel, FJ1
Beaune, P; Cosme, J; Gautier, JC; Lecoeur, S; Perret, A; Pompon, D; Urban, P1
Burchiel, SW; Mounho, BJ1
Burchiel, SW; Salas, VM1
Kim, JH; Stansbury, KH; Strickland, PT; Sutter, TR; Trush, MA; Walker, NJ1
Bucci, T; Fu, PP; Heflich, RH; Von Tungeln, LS; Xia, Q1
Gillam, EM; Guengerich, FP; Inoue, K; Oda, Y; Shimada, T; Sutter, TR; Tsumura, F1
Drahushuk, AT; Honey, S; Kumar, S; O'Keefe, P; Olson, JR; Sikka, HC1
Fang, JL; Lazarus, P; Zheng, Z1
Edenharder, R; Köttgen, V; Krieg, H; Platt, KL1
Bouche, FB; Brandenburger, A; De Buck, SS; Muller, CP1
Celander, MC; James, MO; Lou, Z; Rowland-Faux, L1
Li, PJ; Lin, GF; Wang, J; Wang, X; Zang, SY; Zhou, QX1
Ahmad, S; Doehmer, J; Kabler, SL; Kushman, ME; Morrow, CS; Townsend, AJ1
Chen, J; Li, PJ; Shi, K; Yu, XC; Zang, SY; Zhang, H1
Doehmer, J; Jacob, J; Kabler, SL; Morrow, CS; Seidel, A; Townsend, AJ1
Abedin, Z; Field, J; Sen, S1
Chiu, RK; Godschalk, RW; Sanen, K; Schults, MA; Theys, J; van Schooten, FJ1
Corley, RA; Crowell, SR; Mehinagic, D; Nag, S; Smith, JN1

Reviews

1 review(s) available for benzo(a)pyrene 7,8-dihydrodiol and benzo(a)pyrene

ArticleYear
Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis.
    Life sciences, 1981, Aug-10, Volume: 29, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Amines; Animals; Arachidonic Acid; Arachidonic Acids; Benzo(a)pyrene; Benzofurans; Benzopyrenes; Carcinogens; Dihydroxydihydrobenzopyrenes; Luminol; Nitrofurans; Oxidation-Reduction; Oxyphenbutazone; Phenylbutazone; Polycyclic Compounds; Prostaglandin-Endoperoxide Synthases; Prostaglandins

1981

Other Studies

79 other study(ies) available for benzo(a)pyrene 7,8-dihydrodiol and benzo(a)pyrene

ArticleYear
[A comparative study of the individual characteristics of the excretion of metabolites of benzo(a)pyrene and its carcinogenic effect in rats].
    Voprosy onkologii, 1992, Volume: 38, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; Feces; Least-Squares Analysis; Male; Neoplasms, Experimental; Probability; Rats; Regression Analysis; Time Factors

1992
Biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites.
    Environmental health perspectives, 1992, Volume: 98

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers, Tumor; Dihydroxydihydrobenzopyrenes; Disease Susceptibility; Feces; Histiocytoma, Benign Fibrous; Macaca fascicularis; Male; Peritoneal Neoplasms; Rats; Risk Factors; Species Specificity

1992
Linoleate-dependent co-oxygenation of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol by rat cytosolic lipoxygenase.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5

    Topics: Animals; Benzo(a)pyrene; Cytosol; Dihydroxydihydrobenzopyrenes; Female; Free Radicals; In Vitro Techniques; Kinetics; Linoleic Acid; Linoleic Acids; Lipoxygenase; Lung; Masoprocol; Oxidation-Reduction; Peroxides; Proteins; Rats; Rats, Sprague-Dawley

1992
Action of some retinol derivatives and their provitamins on microsome-catalyzed formation of benzo[a]pyrene-DNA adduct.
    Journal of biochemical toxicology, 1992,Fall, Volume: 7, Issue:3

    Topics: Animals; Benzo(a)pyrene; Biological Availability; Catalysis; Cattle; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Drug Synergism; Microsomes; Vitamin A; Vitamins

1992
Peroxidase-mediated glutathione conjugation of benzo[a]pyrene-7,8-dihydrodiol is enhanced by benzo[a]pyrene phenols in vitro.
    Carcinogenesis, 1992, Volume: 13, Issue:4

    Topics: Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Free Radicals; Glutathione; Peroxidases; Phenols

1992
Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
    Molecular pharmacology, 1990, Volume: 37, Issue:5

    Topics: Animals; Base Sequence; Benzo(a)pyrene; Blotting, Southern; Cell Line; Cells, Cultured; Cloning, Molecular; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; Gene Expression; Liver; Molecular Sequence Data; Mutagenicity Tests; Oligonucleotide Probes; Plasmids; Rats; Rats, Inbred Strains; Restriction Mapping; RNA; Transfection

1990
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol in human mammary epithelial cells: feedback inhibition by 7-hydroxybenzo[a]pyrene.
    Carcinogenesis, 1991, Volume: 12, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Biotransformation; Breast; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Epithelium; Female; Humans

1991
Southern flounder hepatic and intestinal metabolism and DNA binding of benzo[a]pyrene (BaP) metabolites following dietary administration of low doses of BaP, BaP-7,8-dihydrodiol or a BaP metabolite mixture.
    Chemico-biological interactions, 1991, Volume: 79, Issue:3

    Topics: Animals; Benzo(a)pyrene; Bile; Binding Sites; Biotransformation; Carcinogens, Environmental; Diet; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Flounder; Glucuronosyltransferase; Intestinal Mucosa; Microsomes, Liver; Nephropidae

1991
Metabolism of benzo[a]pyrene by human melanocytes in culture.
    Carcinogenesis, 1991, Volume: 12, Issue:10

    Topics: Benzo(a)pyrene; Cells, Cultured; Dihydroxydihydrobenzopyrenes; Extracellular Space; Humans; Intracellular Fluid; Melanocytes; Tritium

1991
Metabolism of benzo[a]pyrene and (-)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes from mirror carp.
    Carcinogenesis, 1991, Volume: 12, Issue:2

    Topics: Animals; Benzo(a)pyrene; Carps; Dihydroxydihydrobenzopyrenes; DNA; Female; Glucuronates; Glucuronic Acid; Glutathione; Liver; Male; Microsomes, Liver; Sulfates; Time Factors; Tritium

1991
Inhibition of liver microsome-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in the rat following glucose administration.
    Cancer letters, 1990, Apr-20, Volume: 50, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Depression, Chemical; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Glucose; Male; Microsomes, Liver; Mutagenicity Tests; Mutation; Rats; Rats, Inbred Strains

1990
[The individual characteristics of the excretion of benzo(a)pyrene metabolites in rats].
    Voprosy onkologii, 1990, Volume: 36, Issue:10

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Dihydroxydihydrobenzopyrenes; Feces; Male; Rats; Spectrometry, Fluorescence; Time Factors

1990
Metabolism of benzo[a]pyrene and (-)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes of brown bullheads.
    Chemico-biological interactions, 1990, Volume: 74, Issue:1-2

    Topics: Animals; Benzo(a)pyrene; Biotransformation; Carbon Radioisotopes; Cells, Cultured; Dihydroxydihydrobenzopyrenes; Female; Fishes; Kinetics; Liver; Male; Seasons; Tritium

1990
In vitro inhibition of the metabolism and mutagenicity of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol by naphthazarin and other naphthol derivatives.
    Biochemical and biophysical research communications, 1987, Feb-13, Volume: 142, Issue:3

    Topics: Benzo(a)pyrene; Dicumarol; Dihydroxydihydrobenzopyrenes; Microsomes; Mutagenicity Tests; Mutagens; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; Naphthols; Naphthoquinones; Oxidation-Reduction; Oxygen Consumption; Quinone Reductases

1987
Induction of cytotoxicity and mutagenesis is facilitated by fatty acid hydroperoxidase activity in Chinese hamster lung fibroblasts (V79 cells).
    Mutation research, 1989, Volume: 224, Issue:2

    Topics: Animals; Arachidonic Acids; Benzo(a)pyrene; Biotransformation; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; Dinoprostone; Fatty Acids; Leukotriene B4; Linoleic Acids; Lipid Peroxides; Mutagens; Mutation; Peroxidases; Thromboxane B2; Xenobiotics

1989
Inhibition of benzo[a]pyrene-7,8-diol formation in vitro by complex organic mixtures.
    Toxicology, 1989, Volume: 55, Issue:1-2

    Topics: Animals; Aroclors; Benzo(a)pyrene; Biotransformation; Dihydroxydihydrobenzopyrenes; Hydrocarbons; In Vitro Techniques; Liver; Rats; Solvents; Time Factors

1989
DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diol.
    Mutation research, 1989, Volume: 219, Issue:4

    Topics: Aging; Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA Damage; DNA Repair; Female; Kidney; Kinetics; Liver; Mice; Mice, Inbred C57BL; Spectrometry, Fluorescence

1989
In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
    Carcinogenesis, 1986, Volume: 7, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Male; Mice; Rats; Rats, Inbred Strains; Skin; Stereoisomerism; Tritium

1986
Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation.
    Chemico-biological interactions, 1987, Volume: 61, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucuronic Acid

1987
Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.
    Cancer research, 1987, Oct-15, Volume: 47, Issue:20

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Epidermis; Female; Half-Life; Kinetics; Mice

1987
Metabolism and DNA adduct formation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in fish cell lines in culture.
    Carcinogenesis, 1987, Volume: 8, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fishes

1987
Differences in the DNA adducts formed in cultured rabbit and rat dermal fibroblasts by benzo(a)pyrene and (-)benzo(a)pyrene-7,8-diol.
    Cancer research, 1988, Dec-15, Volume: 48, Issue:24 Pt 1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fibroblasts; Rabbits; Rats; Skin

1988
Inclusion complex formation of benzo[a]pyrene metabolites with cyclodextrins.
    Analytical chemistry, 1988, Dec-01, Volume: 60, Issue:23

    Topics: Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cyclodextrins; Dextrins; Dihydroxydihydrobenzopyrenes; Hydrolysis; Spectrometry, Fluorescence; Starch

1988
Ellagic acid toxicity and interaction with benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in human bronchial epithelial cells.
    Cell biology and toxicology, 1986, Volume: 2, Issue:1

    Topics: Benzo(a)pyrene; Benzopyrans; Bronchi; Carcinogens; Cells, Cultured; Dihydroxydihydrobenzopyrenes; DNA; Ellagic Acid; Humans; Tumor Stem Cell Assay

1986
Sulfite-dependent mutagenicity of benzo[a]pyrene derivatives.
    Carcinogenesis, 1987, Volume: 8, Issue:8

    Topics: Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; Mutagens; Salmonella typhimurium; Sulfites

1987
Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene.
    Carcinogenesis, 1987, Volume: 8, Issue:11

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cells, Cultured; Dihydroxydihydrobenzopyrenes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship

1987
Persistence of benzo[a]pyrene and 7,8-dihydro-7,8-dihydroxybenzo[a] pyrene in Fischer 344 rats: time distribution of total metabolites in blood, urine and feces.
    Carcinogenesis, 1988, Volume: 9, Issue:2

    Topics: Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; Feces; Inactivation, Metabolic; Rats; Rats, Inbred F344; Time Factors

1988
Stereoselective aspects of the metabolic activation of benzo[a]pyrene by human skin in vitro.
    Chemico-biological interactions, 1988, Volume: 64, Issue:3

    Topics: Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Humans; Organ Culture Techniques; Skin; Stereoisomerism

1988
Modulation of the cytotoxicity and mutagenicity of benzo[a]pyrene and benzo[a]pyrene 7,8-diol by glutathione and glutathione S-transferases in mammalian cells (CHO/HGPRT assay).
    Mutation research, 1987, Volume: 178, Issue:2

    Topics: Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; Female; Fibroblasts; Genes; Glutathione; Glutathione Transferase; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Mixed Function Oxygenases; Mutagenicity Tests; Ovary; Rats

1987
Metabolism of benzo[a]pyrene in primary cultures of human hepatocytes: dose-response over a four-log range.
    Carcinogenesis, 1987, Volume: 8, Issue:7

    Topics: Benzo(a)pyrene; Cells, Cultured; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; Dose-Response Relationship, Drug; Glucuronates; Humans; Liver

1987
Comparative metabolism of benzo(a)pyrene and covalent binding to hepatic DNA in English sole, starry flounder, and rat.
    Cancer research, 1986, Volume: 46, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bile; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; Fishes; Glutathione; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Species Specificity

1986
Human hair follicle benzo[a]pyrene and benzo[a]pyrene 7,8-diol metabolism: effect of exposure to a coal tar-containing shampoo.
    The Journal of investigative dermatology, 1987, Volume: 88, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Carbon Monoxide; Clotrimazole; Coal Tar; Dihydroxydihydrobenzopyrenes; DNA; Drug Interactions; Enzyme Induction; Hair; Hair Preparations; Humans; Ketoconazole; NADP

1987
Host-mediated mutagenicity experiments with benzo[a]pyrene and two of its metabolites.
    Mutation research, 1985, Volume: 156, Issue:3

    Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Male; Mice; Mutagenicity Tests; Mutation; Salmonella typhimurium

1985
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives.
    Carcinogenesis, 1985, Volume: 6, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Dihydroxydihydrobenzopyrenes; Mice; Mice, Inbred C3H

1985
A comparison of the intercalative binding of non-reactive benzo[a]pyrene metabolites and metabolite model compounds to DNA.
    Chemico-biological interactions, 1985, Volume: 55, Issue:1-2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; DNA; Humans; Intercalating Agents; Mice; Mice, Inbred ICR; Models, Chemical; Spectrometry, Fluorescence

1985
Benzo(a)pyrene:DNA adduct formation in early-passage Wistar rat embryo cell cultures: evidence for multiple pathways of activation of benzo(a)pyrene.
    Cancer research, 1986, Volume: 46, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; Hydrolysis; In Vitro Techniques; Rats; Rats, Inbred Strains; Stereoisomerism

1986
Benzo[a]pyrene metabolism and DNA adduct formation mediated by English sole liver enzymes.
    Biochemical pharmacology, 1985, Jan-15, Volume: 34, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; Fishes; In Vitro Techniques; Microsomes, Liver

1985
A comparison of the DNA intercalative binding of bay versus K region metabolites of benzo[a]pyrene.
    Progress in clinical and biological research, 1985, Volume: 172A

    Topics: Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; Spectrometry, Fluorescence

1985
Involvement of cytochrome b5 in the hepatic microsomal metabolism of benzo(a)pyrene.
    Biochemical and biophysical research communications, 1985, Apr-30, Volume: 128, Issue:2

    Topics: Alcoholism; Animals; Benzo(a)pyrene; Benzopyrenes; Cricetinae; Cytochrome b Group; Cytochromes b5; Dihydroxydihydrobenzopyrenes; Food, Formulated; Humans; Male; Mesocricetus; Microsomes, Liver; Mutagenicity Tests

1985
Benzo[a]pyrene metabolism in mouse liver. Association of both 7,8-epoxidation and covalent binding of a metabolite of the 7,8-diol with the Ah locus.
    Biochemical pharmacology, 1985, May-15, Volume: 34, Issue:10

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Chromosome Mapping; Dihydroxydihydrobenzopyrenes; Liver; Mice; Mice, Inbred Strains

1985
Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA binding in mouse lung explants by ellagic acid.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; Ellagic Acid; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred Strains

1985
[Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene].
    Eksperimental'naia onkologiia, 1985, Volume: 7, Issue:6

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Catalysis; Cell Nucleus; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Endoplasmic Reticulum; Enzyme Induction; Intracellular Membranes; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity

1985
Benzo[e]pyrene-induced alterations in the binding of benzo[a]pyrene to DNA in hamster embryo cell cultures.
    Carcinogenesis, 1984, Volume: 5, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Dihydroxydihydrobenzopyrenes; DNA; Embryo, Mammalian; Female; Mesocricetus; Pregnancy; Time Factors

1984
Oxidation of benzo(a)pyrene and 7,8-dihydro-7,8-dihydroxy benzo(a)pyrene by horseradish peroxidase-H2O2 intermediate: fluorometric study.
    Cancer biochemistry biophysics, 1984, Volume: 7, Issue:2

    Topics: Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; Fluorometry; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Oxidation-Reduction; Peroxidases

1984
Effects of phenobarbital, 3-methylcholanthrene and beta-naphthoflavone pretreatment on mouse liver microsomal enzymes and on metabolite patterns of benzo[a]pyrene.
    Biochemical pharmacology, 1981, Jun-01, Volume: 30, Issue:11

    Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Proteins

1981
Uptake of lipophilic carcinogens by plasma lipoproteins. Structure-activity studies.
    Biochimica et biophysica acta, 1981, Sep-24, Volume: 665, Issue:3

    Topics: Benzo(a)pyrene; Benzopyrenes; Carcinogens; Dihydroxydihydrobenzopyrenes; Humans; Kinetics; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Structure-Activity Relationship

1981
Metabolism of benzo(a)pyrene in epidermal keratinocytes and dermal fibroblasts of humans and mice with reference to variation among species, individuals, and cell types.
    Cancer research, 1982, Volume: 42, Issue:5

    Topics: Adolescent; Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Child; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; Female; Humans; Lung; Male; Mice; Mutation; Skin

1982
Inactivation of DNA-binding metabolites of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by glutathione and glutathione S-transferases.
    Carcinogenesis, 1982, Volume: 3, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Nucleus; Cytosol; Dihydroxydihydrobenzopyrenes; DNA; Glutathione; Glutathione Transferase; Male; Rats; Rats, Inbred Strains

1982
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.
    Molecular pharmacology, 1982, Volume: 22, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Quinones; Rats; Rats, Inbred Strains; Time Factors; Uridine Diphosphate Glucuronic Acid

1982
The influence of flow on the metabolism of perfused benzo[a]pyrene by isolated rat lung.
    Chemico-biological interactions, 1983, Volume: 43, Issue:1

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Enzyme Induction; Lung; Male; Perfusion; Rabbits; Rats; Rats, Inbred Strains

1983
Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation.
    Science (New York, N.Y.), 1983, Jul-01, Volume: 221, Issue:4605

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Dihydroxydihydrobenzopyrenes; Epoxy Compounds; Lipid Peroxides; Microsomes, Liver; NADP; Oxidation-Reduction; Polycyclic Compounds; Rats

1983
Formation of phenolic and dihydrodiol metabolites of benzo(a)pyrene in freshly isolated human hair follicles occurs independently.
    Toxicology letters, 1983, Volume: 17, Issue:1-2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Dihydroxydihydrobenzopyrenes; Female; Hair; Humans; Male; Phenols; Structure-Activity Relationship

1983
Rabbit alveolar macrophage-mediated mutagenesis of polycyclic aromatic hydrocarbons in V79 Chinese hamster cells.
    Mutation research, 1983, Volume: 111, Issue:2

    Topics: Animals; Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Line; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; Lung; Macrophages; Mutagenicity Tests; Mutagens; Mutation; Rabbits

1983
Murine strain differences in ovotoxicity following intraovarian injection with benzo(a)pyrene, (+)-(7R,8S)-oxide, (-)-(7R,8R)-dihydrodiol, or (+)-(7R,8S)-diol-(9S,10R)-epoxide-2.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Dihydroxydihydrobenzopyrenes; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Oocytes; Ovarian Neoplasms; Ovary; Species Specificity; Structure-Activity Relationship

1984
Arachidonic acid-dependent cooxidation. A potential pathway for the activation of chemical carcinogens in vivo.
    Biochemical pharmacology, 1984, Nov-01, Volume: 33, Issue:21

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Butylated Hydroxyanisole; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA; Fluorenes; Humans; Oxidation-Reduction; Peroxidases; Prostaglandin-Endoperoxide Synthases; Stereoisomerism

1984
Depression of hepatic cytochrome P450 monooxygenases after chronic environmental tobacco smoke exposure of young ferrets.
    Toxicology letters, 1995, Volume: 76, Issue:3

    Topics: 7-Alkoxycoumarin O-Dealkylase; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Analysis of Variance; Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Dose-Response Relationship, Drug; Down-Regulation; Environmental Exposure; Female; Ferrets; Immunoblotting; Liver; Male; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Pregnancy; Tobacco Smoke Pollution

1995
The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol.
    Molecular carcinogenesis, 1994, Volume: 10, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA, Complementary; Epoxide Hydrolases; Humans; Rabbits; Recombinant Proteins; Tumor Cells, Cultured; Vaccinia virus

1994
Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Mitosis; Oxidoreductases; Rats; Transfection

1993
Treatment of lactating rats with PCBs induces CYP1A1 and enhances the formation of BP 7,8-dihydrodiol, the proximate carcinogen of benzo(a)pyrene.
    The International journal of biochemistry, 1993, Volume: 25, Issue:8

    Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Female; Fetus; Lactation; Microsomes, Liver; Polychlorinated Biphenyls; Pregnancy; Rats; Rats, Sprague-Dawley

1993
Biomarkers of individual susceptibility to carcinogens: application for biological monitoring.
    International archives of occupational and environmental health, 1993, Volume: 65, Issue:1 Suppl

    Topics: Adult; Age Factors; Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers; Carcinogens; Child; Dihydroxydihydrobenzopyrenes; Disease Susceptibility; DNA; DNA Repair; Environmental Monitoring; Female; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Lung Neoplasms; Macaca fascicularis; Male; Methyltransferases; Middle Aged; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Rats; Smoking; Stomach Neoplasms

1993
Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line.
    Biochemical and biophysical research communications, 1996, Jan-17, Volume: 218, Issue:2

    Topics: Alkaloids; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzodioxoles; Biological Transport; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Liver Neoplasms, Experimental; Piperidines; Polyunsaturated Alkamides; Rats; RNA, Messenger; Tumor Cells, Cultured

1996
Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast.
    Pharmacogenetics, 1996, Volume: 6, Issue:6

    Topics: Benzo(a)pyrene; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA Primers; Epoxide Hydrolases; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Polymerase Chain Reaction; Recombinant Proteins; Saccharomyces cerevisiae

1996
Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation.
    Toxicology and applied pharmacology, 1998, Volume: 149, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; B-Lymphocytes; Benzo(a)pyrene; Benzoflavones; Benzoquinones; Calcium; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Humans; Lactams, Macrocyclic; Protein-Tyrosine Kinases; Quinones; Rifabutin

1998
Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol.
    Toxicology and applied pharmacology, 1998, Volume: 151, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Atrial Natriuretic Factor; B-Lymphocytes; bcl-2-Associated X Protein; Benzo(a)pyrene; Cell Line; Dihydroxydihydrobenzopyrenes; DNA Fragmentation; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2

1998
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.
    Carcinogenesis, 1998, Volume: 19, Issue:10

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA Primers; Humans; Oxidation-Reduction; Rats; Recombinant Proteins; Saccharomyces cerevisiae

1998
Tumorigenicity and liver tumor ras-protooncogene mutations in CD-1 mice treated neonatally with 1- and 3-nitrobenzo[a]pyrene and their trans-7,8-dihydrodiol and aminobenzo[a]pyrene metabolites.
    Cancer letters, 1999, Apr-01, Volume: 137, Issue:2

    Topics: Adenoma, Liver Cell; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Carcinoma, Hepatocellular; Chrysenes; Dihydroxydihydrobenzopyrenes; DNA Mutational Analysis; Genes, ras; Liver Neoplasms, Experimental; Male; Mice; Mutagenesis; Mutagens; Mutation

1999
Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.
    Chemical research in toxicology, 1999, Volume: 12, Issue:7

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Epoxide Hydrolases; Humans; Liver; Mutagenicity Tests; Rabbits; Rats; Recombinant Proteins; Salmonella typhimurium

1999
Metabolism of benzo(a)pyrene by duck liver microsomes.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2000, Volume: 126, Issue:3

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; Ducks; Enzyme Induction; Microsomes, Liver; Molecular Conformation

2000
Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:4

    Topics: Benzo(a)pyrene; Cell Line; Chromatography, High Pressure Liquid; Digestive System; Dihydroxydihydrobenzopyrenes; Esophagus; Glucuronides; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Isoenzymes; Larynx; Liver; Lung; Microsomes; Microsomes, Liver; Mouth; Organ Specificity; Palatine Tonsil; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tongue

2002
Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids.
    Mutation research, 2003, Jun-06, Volume: 537, Issue:2

    Topics: Administration, Oral; Animals; Antimutagenic Agents; Benzo(a)pyrene; Bone Marrow Cells; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Dihydroxydihydrobenzopyrenes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fruit; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagens; Plant Extracts; Quercetin; Vegetables

2003
Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis?
    Carcinogenesis, 2005, Volume: 26, Issue:4

    Topics: Alkylation; Animals; Antibodies, Monoclonal; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; DNA Adducts; Female; Humans; Liver Neoplasms; Lymphocytes; Microsomes, Liver; Rats; Rats, Wistar

2005
Properties and regional expression of a CYP3A-like protein in channel catfish intestine.
    Aquatic toxicology (Amsterdam, Netherlands), 2005, May-15, Volume: 72, Issue:4

    Topics: Analysis of Variance; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Dihydroxydihydrobenzopyrenes; Erythromycin; Ictaluridae; Intestinal Mucosa; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Proadifen; Steroid Hydroxylases; Xenobiotics

2005
[Study on continued degradation of BaP and its metabolites].
    Huan jing ke xue= Huanjing kexue, 2006, Volume: 27, Issue:12

    Topics: Bacillus; Benzo(a)pyrene; Biodegradation, Environmental; Dihydroxydihydrobenzopyrenes; Molecular Structure; Soil Pollutants

2006
Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 99, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fibroblasts; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Mutagenicity Tests; Mutagens; Mutation; Stereoisomerism; Transfection

2007
Degradation of metabolites of benzo[a]pyrene by coupling Penicillium chrysogenum with KMnO4.
    Journal of environmental sciences (China), 2007, Volume: 19, Issue:2

    Topics: Benzo(a)pyrene; Benzopyrenes; Biodegradation, Environmental; Dihydroxydihydrobenzopyrenes; Environmental Pollutants; Hydrogen-Ion Concentration; Indicators and Reagents; Penicillium chrysogenum; Potassium Permanganate

2007
Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
    Chemico-biological interactions, 2009, May-15, Volume: 179, Issue:2-3

    Topics: Animals; Benzo(a)pyrene; Cell Proliferation; Cells, Cultured; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutathione S-Transferase pi; Humans; Naphthalenes; Rats; Transgenes

2009
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
    Chemical research in toxicology, 2012, Jan-13, Volume: 25, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma of Lung; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Benzo(a)pyrene; Cell Line, Tumor; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Heme Oxygenase-1; Humans; Lung Neoplasms; Quinones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger

2012
Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene.
    Mutagenesis, 2014, Volume: 29, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cell Hypoxia; Cell Line, Tumor; Chromatography, High Pressure Liquid; Culture Media; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Dihydroxydihydrobenzopyrenes; DNA Adducts; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Kinetics; Mutagens; Oxygen; Time Factors

2014
In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes.
    Toxicology letters, 2017, Mar-05, Volume: 269

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Chrysenes; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Female; Male; Mice; Microsomes, Liver; Polycyclic Aromatic Hydrocarbons; Rats; Rats, Sprague-Dawley; Risk Assessment; Toxicity Tests

2017