Compounds > benzo(a)pyrene 7,8-dihydrodiol
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benzo(a)pyrene 7,8-dihydrodiol and benzo(a)pyrene-7,8-dione

benzo(a)pyrene 7,8-dihydrodiol has been researched along with benzo(a)pyrene-7,8-dione in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Harvey, RG; Penning, TM; Shou, M1
Flowers-Geary, L; Harvey, RG; Penning, TM1
Bleczinski, WF; Burczynski, ME; Flowers, L; Harvey, RG; Penning, TM1
Burczynski, ME; Harvey, RG; Penning, TM1
Harvey, RG; Kazanietz, MG; Penning, TM; Yu, D1
Blair, IA; Jiang, H; Penning, TM; Vudathala, DK1
Blair, IA; Harvey, RG; Mangal, D; Park, JH; Penning, TM; Quinn, AM; Tacka, KA1

Other Studies

7 other study(ies) available for benzo(a)pyrene 7,8-dihydrodiol and benzo(a)pyrene-7,8-dione

ArticleYear
Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions.
    Carcinogenesis, 1992, Volume: 13, Issue:9

    Topics: Alcohol Oxidoreductases; Animals; Benzopyrenes; Catalysis; Dihydroxydihydrobenzopyrenes; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Sprague-Dawley; Subcellular Fractions

1992
Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes.
    Carcinogenesis, 1995, Volume: 16, Issue:11

    Topics: Alcohol Oxidoreductases; Animals; Benzopyrenes; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Dihydroxydihydrobenzopyrenes; In Vitro Techniques; Liver; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Sprague-Dawley

1995
Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase.
    Biochemistry, 1996, Oct-22, Volume: 35, Issue:42

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Benzoquinones; Cells, Cultured; Dihydroxydihydrobenzopyrenes; DNA Adducts; DNA Damage; DNA Fragmentation; DNA, Superhelical; DNA, Viral; Liver; Male; Mutagenicity Tests; Mutagens; Oxidoreductases; Polycyclic Aromatic Hydrocarbons; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

1996
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
    Biochemistry, 1998, May-12, Volume: 37, Issue:19

    Topics: Benzopyrenes; Biotransformation; Carcinoma, Hepatocellular; Catalysis; Dihydroxydihydrobenzopyrenes; DNA, Complementary; Escherichia coli; Genetic Vectors; Glycine; Humans; Isoenzymes; Kinetics; Liver; Oxidation-Reduction; Oxidoreductases; Phospholipid Ethers; Recombinant Proteins; Stereoisomerism; Tumor Cells, Cultured

1998
Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C.
    Biochemistry, 2002, Oct-01, Volume: 41, Issue:39

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Benzopyrenes; Biotransformation; Catalytic Domain; Dihydroxydihydrobenzopyrenes; Enzyme Activation; Enzyme Inhibitors; Holoenzymes; Humans; Naphthalenes; Naphthols; Oxidation-Reduction; Peptide Fragments; Polycyclic Aromatic Hydrocarbons; Protein Kinase C; Quinones; Subcellular Fractions; Tumor Cells, Cultured

2002
Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction.
    Chemical research in toxicology, 2006, Volume: 19, Issue:1

    Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Line, Tumor; Cytochrome P-450 CYP1B1; Dihydroxydihydrobenzopyrenes; Enzyme Induction; Enzyme Inhibitors; Humans; Polychlorinated Dibenzodioxins; Pulmonary Alveoli; Time Factors; Transfection; Tritium

2006
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, May-13, Volume: 105, Issue:19

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Benzopyrenes; Biotransformation; Catechol O-Methyltransferase Inhibitors; Cell Line, Tumor; Comet Assay; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA Breaks, Double-Stranded; DNA Glycosylases; Enzyme Inhibitors; Fluoresceins; Fluorescence; Humans; Isoenzymes; Lung; Oxidation-Reduction; Reactive Oxygen Species; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2008