benzbromarone has been researched along with benzarone in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (53.13) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Anzai, N; Endou, H; Frick, MM; Iwen, TJ; Jutabha, P; Quade, B; Rice, PJ; Ross, IR; Wempe, MF | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chan, WC; Gordon, CP; Williams, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Azzouzi, K; Delcourt, A; Gerbaux, A; Geubel, AP; Nakad, A; Rahier, J; Sempoux, C; Tamo, F | 1 |
| Brasch, H; Iven, H | 1 |
| de Vries, JX; Ittensohn, A; Kohlmeier, M; Walter-Sack, I; Weber, E | 1 |
| Babany, G; Benhamou, JP; Degott, C; Larrey, D; Pessayre, D; Rueff, B | 1 |
| Bonn, R; Chasseaud, LF; Darragh, A; Grote, H; John, BA; Lambe, RF; Sandrock, K; Wood, SG | 1 |
| de Vries, JX; Kocher, J; van de Loo, A; Walter-Sack, I | 1 |
| Bandura, B; Köstering, H; Merten, HA; Wieding, JU | 1 |
| Bösiger, G; Zwillenberg, HH; Zwillenberg, LO | 1 |
| Lange, A; Paul, V | 1 |
| Pevny, I | 1 |
| Betz, E; Knehr, HE | 1 |
| Kronbach, T; Voelter, W | 1 |
| Greiling, H; Kleesiek, K | 1 |
| Ehrly, AM; Landgraf, H; Saeger-Lorenz, K; Vogel, C | 1 |
| Buddecke, E; Schmidt, A; Staubesand, J | 1 |
| Blümel, G; Haas, S; Lill, G; von Eckstädt, AV; Weichenmeier, I | 1 |
| Betz, E; Roth, J; Schlote, W | 1 |
| Bishop, G; Vergin, H | 1 |
| Gumieniczek, A; Przyborowski, L | 1 |
| Adler, M; DeNeve, A; Deprez, C; Devis, G; Hautekeete, ML; Henrion, J; Klöppel, G; Naegels, S | 1 |
| Gehenot, M; Geubel, AP; Horsmans, Y; Rahier, J | 1 |
| Gasser, R; Hänni, A; Kaufmann, P; Krähenbühl, S; Roberts, P; Török, M | 1 |
| Anzai, N; Endou, H; Enomoto, A; Fujimura, M; Miyazaki, H; Shin, HJ; Takeda, M | 1 |
| Hegde, RS; Lang, RA; Pandey, RN; Sumanas, S; Tadjuidje, E; Wang, TS | 1 |
| Hegde, RS; Hu, YC; Mallela, J; Molkentin, JD; Nichols, WC; Pandey, RN; Wang, Y; Wikenheiser-Brokamp, KA; York, AJ | 1 |
| Tseng, HH; Tseng, LW; Yang, HC | 1 |
1 review(s) available for benzbromarone and benzarone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 trial(s) available for benzbromarone and benzarone
| Article | Year |
|---|---|
Benzbromarone disposition and uricosuric action; evidence for hydroxilation instead of debromination to benzarone.
Topics: Adult; Benzbromarone; Benzofurans; Humans; Hydroxylation; Inactivation, Metabolic; Male; Protein Binding; Purines; Uric Acid | 1988 |
[The behavior of blood clotting and its inhibitors under long term treatment with 5,6-benzo-alpha-pyrone (coumarin). Double blind study].
Topics: Anticoagulants; Benzbromarone; Blood Coagulation; Clinical Trials as Topic; Coumarins; Double-Blind Method; Drug Combinations; Humans; Hydroxyethylrutoside; Partial Thromboplastin Time; Random Allocation; Rutin; Time Factors; Venous Insufficiency | 1985 |
[Benzarone for leg edema caused by chronic venous insufficiency].
Topics: Benzbromarone; Benzofurans; Chronic Disease; Clinical Trials as Topic; Edema; Female; Fibrinolytic Agents; Humans; Leg; Male; Venous Insufficiency | 1983 |
[Drug modification of a risk factor of thrombosis in patients with varicosis].
Topics: Adult; Aged; Benzbromarone; Benzofurans; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Premedication; Thrombosis; Varicose Veins | 1982 |
27 other study(ies) available for benzbromarone and benzarone
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing potent human uric acid transporter 1 (hURAT1) inhibitors.
Topics: Animals; Drug Design; Humans; Kidney; Magnetic Resonance Spectroscopy; Organic Anion Transporters; Organic Cation Transport Proteins; Xenopus | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.
Topics: Anti-Bacterial Agents; Bacterial Proteins; DNA; Genes, Bacterial; Peptides, Cyclic; Quorum Sensing; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Trans-Activators; Virulence; Virulence Factors | 2013 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
[Hepatitis caused by benzarone: a second case].
Topics: Aged; Benzbromarone; Chemical and Drug Induced Liver Injury; Female; Fibrinolytic Agents; Humans | 1990 |
The effects of antibiotics and uricosuric drugs on the renal elimination of methotrexate and 7-hydroxymethotrexate in rabbits.
Topics: Animals; Anti-Bacterial Agents; Benzbromarone; Ceftriaxone; Furosemide; Kidney; Metabolic Clearance Rate; Methotrexate; Piperacillin; Probenecid; Rabbits; Sulfamethoxazole; Sulfinpyrazone; Uricosuric Agents | 1988 |
Chronic active hepatitis caused by benzarone.
Topics: Alanine Transaminase; Benzbromarone; Benzofurans; Chemical and Drug Induced Liver Injury, Chronic; Female; Fibrinolytic Agents; Hepatitis, Chronic; Humans; Middle Aged | 1987 |
Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog.
Topics: Adult; Animals; Benzbromarone; Benzofurans; Bile; Biotransformation; Blood Proteins; Chromatography, High Pressure Liquid; Dogs; Feces; Fibrinolytic Agents; Humans; Intestinal Absorption; Kinetics; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Determination of benzarone in human plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. Identification of the conjugates.
Topics: Adult; Arylsulfatases; Benzbromarone; Benzofurans; Biotransformation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glucuronidase; Humans; Indicators and Reagents; Male | 1986 |
[On the site of action of benzarone and some other agents influencing the intracellular concentration of cyclic nucleotides].
Topics: Animals; Benzbromarone; Benzofurans; Binding Sites; Cyclic AMP; Cyclic GMP; Fibroblasts; Humans; In Vitro Techniques; Platelet Aggregation; Rats; Trout | 1982 |
Benzaron allergy.
Topics: Benzbromarone; Benzofurans; Chemical Phenomena; Chemistry; Dermatitis, Contact; Female; Humans; Middle Aged | 1984 |
[Effect of benzarone on the oxygen consumption and the mechanical activity of vascular smooth muscle].
Topics: Animals; Benzbromarone; Benzofurans; Carotid Arteries; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxidative Phosphorylation; Oxygen Consumption; Portal Vein; Rabbits; Rats; Rats, Inbred Strains; Uncoupling Agents | 1983 |
High-performance liquid chromatographic comparison of in vivo and in vitro drug metabolism.
Topics: Animals; Benzbromarone; Benzofurans; Bile; Biotransformation; Body Fluids; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Liver; Male; Mass Spectrometry; Pharmaceutical Preparations; Piperidines; Rabbits; Rats; Species Specificity | 1984 |
Effect of anti-inflammatory agents on the glycosaminoglycan metabolism in cultured human synovial cells.
Topics: Adult; Aged; Anti-Inflammatory Agents; Benzbromarone; Cells, Cultured; Colchicine; Dose-Response Relationship, Drug; Fibrinolytic Agents; Flufenamic Acid; Gabexate; Glycosaminoglycans; Guanidines; Humans; In Vitro Techniques; Kinetics; Knee Joint; Male; Models, Biological; Protease Inhibitors; Synovial Membrane | 1982 |
[Behavior of muscle tissue oxygen pressure in patients with severe intermittent claudication after oral administration of benzarone].
Topics: Benzbromarone; Benzofurans; Fibrinolytic Agents; Humans; Intermittent Claudication; Muscles; Oxygen Consumption | 1983 |
[The effect of benzarone on serum lipids and arterial wall of cholesterol fed rats].
Topics: Animals; Arteries; Benzbromarone; Benzofurans; Blood Pressure; Body Weight; Cholesterol, Dietary; Fibrinolytic Agents; Lipid Metabolism; Lipids; Male; Rats | 1982 |
[Influence of 2-ethyl-3-(4-hydroxybenzoyl)-benzofuran (benzarone) on experimental atheromatosis (author's transl)].
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Benzbromarone; Benzofurans; Cholesterol; Electrodes, Implanted; In Vitro Techniques; Rabbits | 1980 |
High-performance liquid chromatographic determination of benzbromarone and the main metabolite benzarone in serum.
Topics: Benzbromarone; Benzofurans; Chromatography, High Pressure Liquid; Half-Life; Humans; Kinetics | 1980 |
Thin-layer chromatographic analysis of some benzofuran derivatives in human plasma.
Topics: Amiodarone; Benzbromarone; Benzofurans; Chromatography, Thin Layer; Fibrinolytic Agents; Humans; Uricosuric Agents; Vasodilator Agents | 1994 |
Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
Topics: Adult; Aged; Benzbromarone; Biopsy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Fatal Outcome; Female; Fibrinolytic Agents; Hepatic Encephalopathy; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Male; Thrombophlebitis; Venous Insufficiency | 1995 |
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
Topics: Benzbromarone; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Liver Transplantation; Middle Aged | 1994 |
Mechanisms of benzarone and benzbromarone-induced hepatic toxicity.
Topics: Amiodarone; Animals; Apoptosis; Benzbromarone; Benzofurans; Cell Line, Tumor; Hepatocytes; Ketone Bodies; Liver; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Molecular Structure; Necrosis; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2005 |
Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Benzothiazoles; Biological Transport; Captopril; Cells, Cultured; Dogs; Enalapril; Indomethacin; Inhibitory Concentration 50; Organic Anion Transporters; Organic Cation Transport Proteins; Phenylbutazone; Probenecid; Pyridines; Salicylates; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 2011 |
The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.
Topics: Animals; Aorta; Benzbromarone; Cell Movement; Cell Proliferation; DNA-Binding Proteins; Enzyme Inhibitors; Female; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Models, Molecular; Neovascularization, Physiologic; Nuclear Proteins; Protein Tyrosine Phosphatases; RNA Interference; Uricosuric Agents; Zebrafish | 2012 |
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Benzbromarone; Cardiomegaly; Cell Proliferation; Cell Survival; DNA Damage; DNA Repair; DNA-Binding Proteins; Heart Ventricles; Hypoxia; Male; Mice, Transgenic; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Benzarone-induced liver injury: First case report in Asia.
Topics: Adult; Benzbromarone; Chemical and Drug Induced Liver Injury, Chronic; Female; Fibrinolytic Agents; Humans | 2020 |