benserazide has been researched along with tyrosine in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (60.87) | 18.7374 |
| 1990's | 10 (21.74) | 18.2507 |
| 2000's | 6 (13.04) | 29.6817 |
| 2010's | 2 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lorenzo, AV; Snodgrass, SR; Uretsky, NJ | 1 |
| Kapatos, G; Zigmond, M | 1 |
| Agid, Y; Glowinski, J; Javoy, F | 1 |
| Borri, P; Borri-Voltattorni, C; Minelli, A | 1 |
| David, JC | 2 |
| Cooper, RL; Linnoila, M | 1 |
| Freye, E | 1 |
| Burlet, DB | 1 |
| Boireau, A; Bourgoin, S; Hamon, M; Héry, F; Ternaux, JP | 1 |
| Jacoby, JH; Mueller, G; Wurtman, RJ | 1 |
| Colzi, A; Da Prada, M; Zürcher, G | 1 |
| Da Prada, M; Zürcher, G | 1 |
| Dissing, IC; Gerdes, AM; Güttler, F; Lou, H; Lykkelund, C; Pakkenberg, H; Rasmussen, V | 1 |
| Boomsma, F; Hovestadt, A; Man in't Veld, AJ; Meerwaldt, JD; Schalekamp, MA | 1 |
| Cohen, Y; el Gemayel, G; Jacquot, C; Prioux-Guyonneau, M; Trouvin, JH | 1 |
| Lindström, P; Ohlsson, L | 1 |
| Da Prada, M; Haefely, WE; Kettler, R; Schaffner, R; Zürcher, G | 1 |
| Allen, JG; Bird, H; Malcolm, SL; Marion, MH; Marsden, CD; O'Leary, CG; Quinn, NP | 1 |
| Roth, RH; Walters, JR | 1 |
| Fernstrom, JD; Larin, F; Mostafapour, S; Wurtman, RJ | 1 |
| Eplov, L; Nielsen, M; Scheel-Krüger, J | 1 |
| Fuzeau-Braesch, S | 1 |
| Minsker, DH; Stokes, AL | 1 |
| Anagnoste, B; Battista, A; Fuxe, K; Goldstein, M; Ogawa, M; Ungerstedt, U | 1 |
| Dairman, W; David, JC; Udenfriend, S | 1 |
| Matussek, N | 1 |
| Fung, YK; Uretsky, NJ | 1 |
| Edwards, DJ | 1 |
| Riederer, P | 1 |
| Himori, N; Mishima, K | 1 |
| Akaike, N; Himori, N; Kurasawa, M; Mishima, K; Tanaka, Y | 1 |
| Antonin, KH; Bieck, PR; Dostert, P; Farger, G; Nilsson, EB; Schmidt, EK; Strolin Benedetti, M; Waldmeier, PC | 1 |
| Brenci, S; Indiveri, F; Lotti, G; Musso, NR; Setti, M | 1 |
| Achilli, G; Banting, A; Banting, S; Le Bars, D; Weil-Fugazza, J | 1 |
| Crevoisier, C; Dingemanse, J; Kleinbloesem, CH; Wood, ND; Zürcher, G | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Lankhaar, G; Ouwerkerk, M | 1 |
| Beiske, A; Fotteler, B; Jorga, KM; Larsen, JP; Moe, B; Schleimer, M; Schmitt, M | 1 |
| Parada, A; Serrão, P; Soares-da-Silva, P | 1 |
| Calvi-Gries, F; Crevoisier, C; Nilsen, T; Zerr, P | 1 |
| Almeida, L; Falcão, A; Loureiro, A; Machado, R; Maia, J; Silveira, P; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Muhlack, S; Müller, T; Przuntek, H; Twiehaus, S; Welnic, J; Woitalla, D | 1 |
| Muhlack, S; Müller, T; Welnic, J | 1 |
| Almeida, L; Costa, R; Falcão, A; Fernandes-Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, JF; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Adamiak, U; Bialecka, M; Gawronska-Szklarz, B; Kaldonska, M; Klodowska-Duda, G; Safranow, K; Wyska, E | 1 |
| Ishihara, A; Kihira, K; Kimura, Y; Matsumoto, M; Miyachi, T; Nakamura, T; Ohtsuki, T; Yamawaki, T | 1 |
11 trial(s) available for benserazide and tyrosine
| Article | Year |
|---|---|
Tetrahydrobiopterin and Parkinson's disease.
Topics: Adult; Antiparkinson Agents; Benserazide; Biopterins; Clinical Trials as Topic; Drug Combinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Clinical and animal experiments concerning the function of brain catecholamines.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Catecholamines; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Dopamine; Form Perception; Humans; Lithium; Locomotion; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Placebos; Rats; Reaction Time; Reserpine; Schizophrenia; Serotonin; Stimulation, Chemical; Time Factors; Tyrosine | 1971 |
Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antiparkinson Agents; Benserazide; Carboxy-Lyases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Comparative single- and multiple-dose pharmacokinetics of levodopa and 3-O-methyldopa following a new dual-release and a conventional slow-release formulation of levodopa and benserazide in healthy subjects.
Topics: Benserazide; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Humans; Levodopa; Metabolic Clearance Rate; Time Factors; Tyrosine | 1998 |
The effect of tolcapone on the pharmacokinetics of benserazide.
Topics: Aged; Antiparkinson Agents; Benserazide; Benzophenones; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Time Factors; Tolcapone; Tyrosine | 1999 |
Effects of food on the pharmacokinetics of levodopa in a dual-release formulation.
Topics: Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Female; Food; Food-Drug Interactions; Half-Life; Humans; Levodopa; Male; Time Factors; Tyrosine | 2003 |
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine | 2003 |
Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Area Under Curve; Benserazide; Biological Availability; Dihydroxyphenylalanine; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors; Tyrosine | 2004 |
Acute levodopa administration reduces cortisol release in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Benserazide; Down-Regulation; Enzyme Inhibitors; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Levodopa; Male; Middle Aged; Neural Pathways; Parkinson Disease; Raphe Nuclei; Serotonin; Tyrosine | 2007 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine; Young Adult | 2009 |
Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.
Topics: Age of Onset; Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Therapy, Combination; Dyskinesias; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Nitrophenols; Parkinson Disease; Severity of Illness Index; Tolcapone; Tyrosine | 2010 |
35 other study(ies) available for benserazide and tyrosine
| Article | Year |
|---|---|
Studies on the mechanism of depletion of striatal dopamine by alpha-methyl-m-tyrosine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Brocresine; Corpus Striatum; Dopamine; Homovanillic Acid; In Vitro Techniques; Male; Methyltyrosines; p-Hydroxyamphetamine; Rats; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 1975 |
Dopamine biosynthesis from L-tyrosine and L-phenylalanine in rat brain synaptosomes: preferential use of newly accumulated precursors.
Topics: Animals; Benserazide; Carbon Dioxide; Corpus Striatum; Dopamine; Hydrogen-Ion Concentration; Hypotonic Solutions; Male; Monoiodotyrosine; Olfactory Bulb; Phenylalanine; Rats; Synaptosomes; Time Factors; Tryptophan; Tyrosine | 1977 |
Oxotremorine- and atropine-induced changes of dopamine metabolism in the rat striatum.
Topics: Animals; Atropine; Benserazide; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Male; Oxotremorine; Rats; Tyrosine | 1975 |
Interaction of N-(DL-seryl)N'-(2,3,4-trihydroxybenzyl)-hydrazine with L-dopa decarboxylase from pig kidney.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Dopa Decarboxylase; Hydrazines; Kidney; Kinetics; Levodopa; Protein Binding; Spectrophotometry; Spectrophotometry, Ultraviolet; Swine; Tyrosine | 1977 |
Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system.
Topics: Animals; Benserazide; Biotransformation; Cobalt; Cysteine; Glutathione; Humans; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Tyrosine | 1976 |
Lethality of tyrosine in mice: its potentiation by decarboxylase inhibitors and reversal byascorbic acid.
Topics: Animals; Ascorbic Acid; Benserazide; Brocresine; Carbidopa; Drug Synergism; Intestinal Absorption; Kidney; Lethal Dose 50; Liver; Male; Mice; Phenylpyruvic Acids; Tyrosine; Tyrosine Decarboxylase | 1976 |
Reinstatement of vaginal cycles in aged female rats.
Topics: Aging; Animals; Benserazide; Carbidopa; Dose-Response Relationship, Drug; Drug Interactions; Estrus; Female; Fusaric Acid; Hypophysectomy; Levodopa; Phenoxybenzamine; Pimozide; Pregnancy; Propranolol; Rats; Tyrosine; Vagina | 1976 |
Tyrosine hydroxylation in the rat striatum after fentanyl and droperidol in vivo.
Topics: Animals; Benserazide; Corpus Striatum; Dihydroxyphenylalanine; Droperidol; Fentanyl; Hydroxylation; Male; Morphine; Rats; Tyrosine | 1976 |
[Endogenous catecholamines and excitability of the superior cervical ganglion of the rat (author's transl)].
Topics: Animals; Benserazide; Catecholamines; Chromaffin System; Ganglia, Autonomic; Guanethidine; Iproniazid; Levodopa; Male; Rats; Rats, Inbred Strains; Reserpine; Tyrosine | 1976 |
Effects of halothane and nitrous oxide anaesthesia on 5-HT turn-over in the rat brain.
Topics: 5-Hydroxytryptophan; Anesthesia; Animals; Benserazide; Brain; Halothane; Hydroxyindoleacetic Acid; Male; Nitrous Oxide; Pargyline; Rats; Serotonin; Time Factors; Tryptophan; Tyrosine | 1975 |
Thyroid state and brain monoamine metabolism.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain; Dihydroxyphenylalanine; Hyperthyroidism; Hypothyroidism; Male; Parathyroid Glands; Rats; Thyroid Gland; Thyroidectomy; Thyroxine; Tryptophan; Tyrosine | 1975 |
Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.
Topics: Animals; Benserazide; Benzophenones; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Electrochemistry; Erythrocytes; Half-Life; In Vitro Techniques; Levodopa; Male; Nitrophenols; Norepinephrine; Rats; Rats, Inbred Strains; Tolcapone; Tyrosine | 1990 |
Simple automated high-performance liquid chromatographic column-switching technique for the measurement of dopa and 3-O-methyldopa in plasma.
Topics: Animals; Autoanalysis; Benserazide; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Electrochemistry; Humans; In Vitro Techniques; Indicators and Reagents; Male; Rats; Specimen Handling; Tyrosine | 1990 |
Treatment of idiopathic parkinsonism with L-dopa in the absence and presence of decarboxylase inhibitors: effects on plasma levels of L-dopa, dopa decarboxylase, catecholamines and 3-O-methyl-dopa.
Topics: Administration, Oral; Aged; Benserazide; Carboxy-Lyases; Catecholamines; Dopa Decarboxylase; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Phenytoin; Time Factors; Tyrosine | 1989 |
Re-evaluation of the L-dopa loading effect on dopamine metabolism in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Effects of 5-hydroxytryptamine, dopamine, and aromatic L-amino acids on growth hormone (GH)-releasing factor-stimulated GH release in rat anterior pituitaries.
Topics: Animals; Benserazide; Carbidopa; Dopamine; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Kinetics; Levodopa; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Serotonin; Tyrosine | 1987 |
Inhibition of decarboxylase and levels of dopa and 3-O-methyldopa: a comparative study of benserazide versus carbidopa in rodents and of Madopar standard versus Madopar HBS in volunteers.
Topics: Administration, Oral; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Carbidopa; Delayed-Action Preparations; Dihydroxyphenylalanine; Dogs; Dopa Decarboxylase; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hydrazines; Kidney; Levodopa; Liver; Male; Mice; Rats; Time Factors; Tyrosine | 1987 |
Single-dose pharmacokinetics of Madopar HBS in patients and effect of food and antacid on the absorption of Madopar HBS in volunteers.
Topics: Adult; Antacids; Benserazide; Biological Availability; Delayed-Action Preparations; Drug Combinations; Eating; Gastric Mucosa; Humans; Hydrazines; Levodopa; Middle Aged; Stomach; Tyrosine | 1987 |
Dopaminergic neurons: drug-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow.
Topics: Animals; Apomorphine; Benserazide; Brain; Brain Chemistry; Dihydroxyphenylalanine; Dioxoles; Dopamine; Fluorometry; Hydroxybutyrates; Lactones; Male; Neurons; Phenylacetates; Piperazines; Pyrimidines; Rats; Synaptic Transmission; Time Factors; Tritium; Tyrosine; Tyrosine 3-Monooxygenase | 1974 |
Brain catechol synthesis: control by train tyrosine concentration.
Topics: Alanine; Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Fenclonine; Histidine; Leucine; Lysine; Male; Phenylalanine; Rats; Tryptophan; Tyrosine | 1974 |
Protriptyline induced inhibition of the in vivo 3H-noradrenaline synthesis from 3H-L-dopa in the rat brain.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Brain Chemistry; Catecholamines; Cerebral Ventricles; Chromatography, Ion Exchange; Dibenzocycloheptenes; Homovanillic Acid; Injections; Levodopa; Male; Norepinephrine; Propylamines; Rats; Specific Pathogen-Free Organisms; Spectrometry, Fluorescence; Time Factors; Tritium; Tyrosine | 1974 |
[Effects of injections of different substrates and an enzyme inhibitor on pigmentation in normal and albino Locusta migratoria L. (Orthop.)].
Topics: Albinism; Amino Acids; Animals; Ascorbic Acid; Benserazide; Folic Acid; Grasshoppers; Nialamide; Pigmentation; Reserpine; Tryptophan; Tyrosine | 1974 |
Aterial blood pressure in dogs: effects of m-tyrosine alone or in combination with inhibitors of aromatic amino acid decarboxylase; relative hypotensive potencies of L-dopa, DL-m-tyrosine, and L-m-tyrosine.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Blood Pressure; Carbidopa; Dihydroxyphenylalanine; Dogs; Female; Heart Rate; Hydrazines; Male; Tyrosine | 1974 |
Action of m-tyrosine in experimental models: evidence for possible antiparkinsonian activity.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Benserazide; Brain Chemistry; Denervation; Dihydroxyphenylalanine; Haplorhini; Histocytochemistry; Hydroxydopamines; Models, Biological; Rats; Receptors, Drug; Reserpine; Spectrometry, Fluorescence; Substantia Nigra; Tremor; Tyrosine | 1973 |
On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan.
Topics: Administration, Oral; Amino Acids; Animals; Benserazide; Carbon Radioisotopes; Carboxy-Lyases; Dopa Decarboxylase; Kidney; Leucine; Liver; Male; Phenylalanine; Rats; Time Factors; Tryptophan; Tyramine; Tyrosine; Valine | 1974 |
The differential effects of amphetamine and methylphenidate on the biosynthesis of [3H]dopa from [3H]tyrosine in mouse striata in vivo.
Topics: Amphetamine; Animals; Benserazide; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Male; Methylphenidate; Mice; Synaptosomes; Tyrosine | 1982 |
Possible role of octopamine and tyramine in the antihypertensive and antidepressant effects of tyrosine.
Topics: Animals; Benserazide; Blood Pressure; Brain; Ethanol; Ethylene Glycols; Gas Chromatography-Mass Spectrometry; Male; Octopamine; Phenols; Phenylacetates; Phenylethyl Alcohol; Rats; Rats, Inbred Strains; Tyramine; Tyrosine | 1982 |
L-dopa competes with tyrosine and tryptophan for human brain uptake.
Topics: Aged; Benserazide; Blood-Brain Barrier; Brain; Female; Humans; Levodopa; Male; Parkinson Disease; Tryptophan; Tyrosine | 1980 |
The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Benserazide; Benzophenones; Catalepsy; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Synergism; Haloperidol; Kinetics; Levodopa; Male; Mice; Mice, Inbred C57BL; Nitrophenols; Tolcapone; Tyrosine | 1994 |
3-O-methyldopa attenuates the effects of Madopar on the haloperidol-induced cataleptic behavior and the locomotor activity in the mouse.
Topics: Animals; Benserazide; Catalepsy; Drug Combinations; Haloperidol; Levodopa; Male; Mice; Motor Activity; Tyrosine | 1994 |
Clinical pharmacology of the new COMT inhibitor CGP 28,014.
Topics: Amidines; Animals; Benserazide; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Isoquinolines; Kinetics; Methoxyhydroxyphenylglycol; Norepinephrine; Pyridones; Rats; Tyrosine; Vanilmandelic Acid | 1993 |
Catecholamine content and in vitro catecholamine synthesis in peripheral human lymphocytes.
Topics: Adult; alpha-Methyltyrosine; Aromatic Amino Acid Decarboxylase Inhibitors; B-Lymphocytes; Benserazide; Catecholamines; Chromatography, High Pressure Liquid; Disulfiram; Dopamine; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Female; Fusaric Acid; Humans; Levodopa; Male; Methyltyrosines; Norepinephrine; T-Lymphocytes; Tyrosine; Tyrosine 3-Monooxygenase | 1996 |
Tyrosine and tryptophan derivatives in pig lumbar cerebrospinal fluid. Effects of subchronic administration of dopa associated with benserazide.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Benserazide; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Kynurenine; Levodopa; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Swine; Tryptamines; Tryptophan; Tyrosine | 1996 |
The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Kidney; Liver; Male; Neurons; Parkinson Disease; Rats; Tyrosine | 2000 |
Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Biomarkers; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Progression; Dopa Decarboxylase; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Japan; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Prospective Studies; Treatment Outcome; Tyrosine | 2011 |