benphothiamine has been researched along with thiamine in 148 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.35) | 18.7374 |
| 1990's | 15 (10.14) | 18.2507 |
| 2000's | 49 (33.11) | 29.6817 |
| 2010's | 64 (43.24) | 24.3611 |
| 2020's | 18 (12.16) | 2.80 |
| Authors | Studies |
|---|---|
| Bitsch, R; Grüneklee, D; Heuzeroth, L; Möller, J; Wolf, M | 1 |
| Kolomoĭskaia, MB; Latypova, GA; Petrosova, GI | 1 |
| Hanawa, T; Hidaka, M; Ikoma, R; Sugihara, M; Tsuchiya, T; Watanabe, A | 1 |
| Kaneda, Y; Yamamoto, J | 1 |
| Federlin, K; Lindemann, A; Stracke, H | 1 |
| Loew, D | 1 |
| Di Rocco, M; Patrini, C; Rimini, A; Rindi, G | 1 |
| Haase, W; Kaumeier, S; Kretschmar, C | 1 |
| Freudenthaler, S; Gleiter, CH; Gundert-Remy, U; Schreeb, KH; Vormfelde, SV | 1 |
| Mincheva, L; Mitkov, M; Pavlova, M; Simeonov, S; Troev, D | 1 |
| Bitsch, R; Greb, A | 1 |
| Hilbig, R; Rahmann, H | 1 |
| Danilov, AB; Sadekov, RA; Veĭn, AM | 1 |
| Kempler, P; Nagybéganyi, E; Ory, I; Pál, B; Porochnavec, M; Winkler, G | 1 |
| Bitsch, R; Frank, T; Maiwald, J; Stein, G | 2 |
| Bitsch, I; Netzel, M; Ziems, M | 1 |
| Bitsch, I; Borsch, C; Jung, KH; Netzel, M; Noll, E; Ziems, M | 1 |
| Balabolkin, MI; Kreminskaia, VM | 1 |
| Bitsch, I; Bitsch, R; Frank, T; Geyer, J; Hoppe, PP; Krämer, K; Netzel, M | 1 |
| Ayazpoor, U | 1 |
| Bitsch, I; Bretzel, RG; Federlin, KF; Geyer, J; Hammes, HP; Köpcke, W; Mavrakis, K; Netzel, M; Sauerland, C; Stracke, H; Werkmann, D | 1 |
| Anisimova, EI; Danilov, AB | 1 |
| Allione, A; La Selva, M; Molinar Min, A; Molinatti, GM; Pomero, F; Porta, M | 1 |
| Bergfeld, R; Bierhaus, A; Brownlee, M; Du, X; Edelstein, D; Giardino, I; Hammes, HP; Hannak, D; Ju, Q; Lin, J; Matsumura, T; Nawroth, P; Neumaier, M; Taguchi, T | 1 |
| Monnier, VM; Obrenovich, ME | 1 |
| Ahmed, N; Babaei-Jadidi, R; Battah, S; Karachalias, N; Thornalley, PJ | 1 |
| FUKUI, S; MAEDA, Y; OISHI, N | 1 |
| Kempler, P | 2 |
| Bezzubenko, LA; Manuĭlov, OE | 1 |
| Haupt, E; Köpcke, W; Ledermann, H | 1 |
| Suzuki, S | 1 |
| Imaizumi, T; Yamagishi, S | 1 |
| Nakamura, J | 1 |
| Ahmed, N; Babaei-Jadidi, R; Karachalias, N; Kupich, C; Thornalley, PJ | 1 |
| Ceylan-Isik, AF; Li, Q; Li, SY; Ren, J; Wu, S | 1 |
| Ren, J; Wu, S | 1 |
| Caram-Salas, NL; Granados-Soto, V; Medina-Santillán, R; Reyes-García, G; Rocha-González, HI; Sánchez-Ramírez, GM; Vidal-Cantú, GC | 1 |
| Campesi, I; Emanueli, C; Gadau, S; Graiani, G; Invernici, G; Madeddu, P; Meloni, M; Spillmann, F; Todaro, M; Van Linthout, S; Ward, K | 1 |
| Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C | 1 |
| Feccia, T; Federici, M; Fukamizu, A; Lauro, D; Lauro, R; Marchetti, V; Menghini, R; Rizza, S; Vivanti, A | 1 |
| Gnezdilov, AV; Medvedeva, LA; Samoĭlova, NV; Slashchuk, IuI; Syrovegin, AV; Zagorul'ko, OI | 1 |
| Gawlowski, T; Götting, C; Horstmann, T; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D; Uribarri, J; Vlassara, H | 1 |
| Bilski, B; Małecka, SA; Poprawski, K | 1 |
| Jermendy, G | 1 |
| Kempler, P; Várkonyi, T | 1 |
| Götting, C; Kleesiek, K; Negrean, M; Salomon, J; Stirban, A; Stratmann, B; Tschoepe, D | 1 |
| Chappell, AS; D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Smith, TR; Wang, F; Wernicke, JF | 1 |
| Achenbach, U; Bretzel, RG; Federlin, K; Gaus, W; Stracke, H | 1 |
| Bahner, U; Dette, EM; Heidland, A; Schmid, U; Schupp, N; Stopper, H; Winkler, M | 1 |
| Bettendorff, L; Evrard, B; Gangolf, M; Piette, M; Plumier, JC; Seyen, S; Volvert, ML | 1 |
| Beltramo, E; Berrone, E; Porta, M; Tarallo, S | 3 |
| Brownlee, M; Du, X; Edelstein, D | 1 |
| Balakumar, P; Chakkarwar, VA; Singh, M | 1 |
| Ramana, KV; Subramanyam, S; Yadav, UC | 1 |
| Du, J; Majumdar, AP; Patel, BB; Rishi, AK; Sarkar, FH; Tarca, AL; Wali, A; Yu, Y | 1 |
| Maksimov, NI; Opolonskiĭĭ, DV | 1 |
| Beltramo, E; Berrone, E; Nizheradze, K; Porta, M; Tarallo, S | 1 |
| Maksimov, NI; Opolonskiĭ, DV | 1 |
| Balakumar, P; Reddy, K; Verma, S | 1 |
| Levin, OS; Moseĭkin, IA | 1 |
| Caporali, A; Emanueli, C; Katare, RG; Madeddu, P; Meloni, M; Oikawa, A | 1 |
| Balakumar, P; Krishan, P; Rohilla, A; Solairaj, P; Thangathirupathi, A | 1 |
| Kalariya, NM; Ramana, KV; Srivastava, SK; Yadav, UC | 1 |
| Babaei-Jadidi, R; Karachalias, N; Rabbani, N; Thornalley, PJ | 1 |
| Chen, J; Dong, W; Fei, G; Gong, N; Gu, F; Pan, X; Qin, Y; Sun, X; Xu, TL; Xu, Z; Yu, M; Yu, Z; Zhao, J; Zhao, L; Zhong, C | 1 |
| Achenbach, U; Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Kleefstra, N; Klooster, A; Mijnhout, GS; Navis, GJ; Slingerland, RJ; van Oeveren, W | 1 |
| Kempler, P; Winkler, G | 1 |
| Caporali, A; Emanueli, C; Katare, R; Madeddu, P | 1 |
| Du, Y; Kern, TS; Kowluru, A | 1 |
| Adaikalakoteswari, A; Ehrlich, G; Gross, ML; Hammes, HP; Kihm, LP; Klein, J; Mertes, L; Müller-Krebs, S; Nawroth, PP; Schwenger, V; Thornalley, PJ; Zeier, M | 1 |
| Kornienko, AM; Kornienko, RA | 1 |
| Ramana, KV; Shoeb, M | 1 |
| Déciga-Campos, M; Flores-Murrieta, F; Montiel-Ruiz, RM; Reyes-García, G | 1 |
| Castilho, G; de Souza Pinto, R; Inada, NM; Machado-Lima, A; Nakandakare, ER; Paim, BA; Passarelli, M; Vercesi, AE | 1 |
| Chand, P; Garg, N; Kaur, L; Syngle, A; Vohra, K | 1 |
| Zaĭtseva, OV | 1 |
| Diep, LM; Fraser, DA; Hanssen, KF; Hovden, IA; Nilsen, KB; Seljeflot, I; Sveen, KA | 1 |
| Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Groenier, KH; Heeringa, P; Kleefstra, N; Navis, GJ; Schalkwijk, CG; Scheijen, JL | 1 |
| Antoniv, TV; Antoniv, VF; Efimochkina, KV; Kakupshev, AU; Popadiuk, VI | 1 |
| Fei, GQ; Jin, LR; Pan, XL; Sun, XJ; Zhao, L; Zhao, N; Zhong, CJ | 1 |
| Angelini, G; Avolio, E; Beltrami, AP; Cesselli, D; Emanueli, C; Katare, R; Madeddu, P; Munasinghe, PE; Muthukrishnan, D; Oikawa, A | 1 |
| Bridges, AS; Coleman, JL; Fitzpatrick, BJ; Hurt, JK; Taylor-Blake, B; Vihko, P; Zylka, MJ | 1 |
| Atanesian, AG; Kosiakov, SIa | 1 |
| Zhestikova, MG | 1 |
| Engelen, L; Schalkwijk, CG; Stehouwer, CD | 1 |
| Duarte, FV; Gomes, AP; Palmeira, CM; Rolo, AP; Teodoro, JS; Varela, AT | 1 |
| Garg, S; Syngle, A; Vohra, K | 1 |
| Jordao, AA; Portari, GV; Vannucchi, H | 1 |
| Murashko, NK | 1 |
| Makhova, AA; Shikh, EV; Zhuravleva, MV | 1 |
| Pop, A; Stirban, A; Tschoepe, D | 1 |
| Harisa, GI | 1 |
| Asghar, M; Kousar, S; Sheikh, MA | 1 |
| Fischer, A; Heckermann, S; Pop, A; Stirban, A; Tschoepe, D | 1 |
| Butler, MG; Campbell, J; He, J; Manzardo, AM; Penick, EC; Poje, A | 1 |
| Cheng, Z; Gu, Z; Guo, X; Li, S; Liu, X; Xie, F; Yu, P | 1 |
| Samir, A; Segin, VB; Sergienko, AA; Sergienko, VA | 1 |
| Minareci, E; Nacitarhan, C; Sadan, G | 1 |
| Jung, KH; Lee, EJ; Lee, JH; Lee, KH; Paik, JY; Park, JW; Quach, CH | 1 |
| Gor, D; Rangoonwala, AN; Raval, AD; Thakker, D; Walia, R | 1 |
| Abdelwahab, NS; Fayed, AS; Hegazy, MA | 1 |
| Bjelobaba, I; Bozic, I; Laketa, D; Lavrnja, I; Milenkovic, I; Nedeljkovic, N; Pekovic, S; Savic, D | 1 |
| An, DT; Espinoza, JL; Kondo, Y; Nakao, S; Sasaki, M; Sugimori, N; Takami, A; Trung, LQ; Wakayama, T | 1 |
| Butler, MG; Manzardo, AM; Pendleton, T; Penick, EC; Poje, A | 1 |
| Carter, SG; Varadi, G; Zhu, Z | 1 |
| Deminice, R; Jordão, AA; Ovidio, PP; Portari, GV | 1 |
| Bao, W; Chen, Z; Fei, G; Guan, Y; Pan, S; Pan, X; Ren, S; Zhong, C | 1 |
| Fayed, AS; Hegazy, MA; Wahab, NS | 1 |
| Han, S; Hong, T; Lee, J; Lee, S; Park, G; Park, WS; Seo, Y; Youn, S | 1 |
| Arora, S; Elwadhi, D; Gupta, M; Rastogi, R; Verma, P | 1 |
| Anthony, DC; Bazhenova, N; Bettendorff, L; Lesch, KP; Markova, N; Strekalova, T; Svistunov, A; Vignisse, J | 1 |
| Anthony, DC; Bazhenova, N; Bettendorff, L; Caron, N; Coumans, B; Gorlova, A; Lakaye, B; Malgrange, B; Markova, N; Pavlov, D; Sambon, M; Shevtsova, E; Strekalova, T; Svistunov, A; Vignisse, J; Wins, P | 1 |
| Jermendy, G; Kempler, P; Keresztes, K; Körei, A; Lengyel, C; Martos, T; Nyiraty, S; Putz, Z; Stirban, A; Várkonyi, T | 1 |
| Colakoglu, N; Kaman, D; Ustuner, MA | 1 |
| Ahuja, M; Beal, MF; Bettendorff, L; Calingasan, NY; Dumont, M; Elipenahli, C; Gazaryan, IG; Gerges, M; Gibson, GE; Hushpulian, DM; Jainuddin, S; Kaidery, NA; Smirnova, NA; Stack, C; Starkov, AA; Starkova, N; Tapias, V; Thomas, B; Vignisse, J; Wakade, S; Xu, H | 1 |
| Belur, PD; Howarth, FC; Ojha, S; Raj, V; Subramanya, SB | 1 |
| Karkowski, G; Kielczewski, S; Kuniewicz, M; Lelakowski, J | 1 |
| Anthony, DC; Babaevskaya, D; Bettendorff, L; Gorlova, A; Lesсh, KP; Pavlov, D; Ponomarev, ED; Proshin, A; Sambon, M; Shafarevich, I; Strekalova, T | 1 |
| Bhagwat, NM; Dalwadi, P; Joshi, AS; Thakur, DS | 1 |
| Gonçalves, ÁC; Moreira, EJS; Portari, GV | 1 |
| Bartlett, MG; Byrnes, CC; Jonus, HC; Kim, J; Said, HM; Valle, ML; Zastre, JA | 1 |
| Ahmed, LA; El-Khatib, A; Galal, O; Hassan, OF; Mansour, DF | 1 |
| Crowley, DC; Evans, M; Guthrie, N; Langston, J; Sulley, AM | 1 |
| Božić, I; Djedovic, N; Lavrnja, I; Miljković, Đ | 1 |
| Gonçalves, AC; Moraes, RCM; Portari, GV; Singulani, MP; Torrão, ADS | 1 |
| Gaus, W; Pop-Busui, R; Schuerholz, T; Schumacher, J; Stirban, OA; Zeller-Stefan, H; Ziegler, D | 1 |
| Bettendorff, L; Chen, H; Chen, Z; Cirio, R; Flowers, SA; Fonzetti, P; Franchino-Elder, J; Gerber, LM; Gibson, GE; Grandville, T; Habeck, C; Hirsch, JA; Jordan, B; Luchsinger, JA; Schupf, N; Stern, Y; Xu, H | 1 |
| Erdogan, E; Erdogan, MA; Erdogan, MM; Koc, S; Turk, A; Yalcin, A | 1 |
| Cao, W; Chen, H; Chen, W; Li, H; Li, X; Lin, P; Liu, C; Sheng, L; Xu, H; Yang, M; Yuan, F; Zhong, C | 1 |
| Abbas, SS; Badawey, AM; Bakr, MA; Hegazy, MA | 1 |
| Bettendorff, L; Sambon, M; Wins, P | 1 |
| Qian, T; Qiu, H; Sang, S; Xu, Y; Zhao, L; Zhong, C | 1 |
| Kato, A; Kato, K; Niimi, N; Nishito, Y; Sango, K; Takaku, S; Tatsumi, Y; Yako, H | 1 |
| Anderson, ET; Bhawal, R; Fu, Q; Gibson, GE; Zhang, S | 1 |
| Al-Hasani, H; Bönhof, GJ; Herder, C; Icks, A; Knebel, B; Kuss, O; Reule, C; Roden, M; Sipola, G; Strassburger, K; Strom, A; Wollmann, JC; Ziegler, D | 1 |
| Allowitz, KV; Baloch, OA; Harames, K; Ramana, KV; Taylor, JR; Yoo, JJ | 1 |
| Cardinali, CAEF; Donato, J; Gonçalves, AC; Guerra-Shinohara, EM; Kleinridders, A; Leboucher, A; Lima, GCA; Moraes, RCM; Portari, GV; Torrão, ADS | 1 |
| Bettendorff, L | 1 |
18 review(s) available for benphothiamine and thiamine
| Article | Year |
|---|---|
Pharmacokinetics of thiamine derivatives especially of benfotiamine.
Topics: Absorption; Adjuvants, Immunologic; Administration, Oral; Animals; Biological Availability; Chelating Agents; Half-Life; Humans; Nerve Fibers; Thiamine | 1996 |
[Treatment of neuropathies].
Topics: Adjuvants, Immunologic; Capsaicin; Diabetic Neuropathies; Diagnosis, Differential; Humans; Liver Diseases; Peripheral Nervous System Diseases; Randomized Controlled Trials as Topic; Thiamine; Treatment Outcome | 2004 |
[Role of mitochondrial dysfunction in pathogenesis of diabetic microangiopathy].
Topics: Antioxidants; Coenzymes; Diabetic Angiopathies; DNA Damage; DNA, Mitochondrial; Drug Design; Electron Transport; Humans; Insulin Resistance; Mitochondria; Mitochondrial Diseases; Mutation; Oxidative Stress; Signal Transduction; Superoxides; Thiamine; Transcription Factors; Ubiquinone | 2005 |
[Progress on the drug therapy for diabetic microangiopathies: AGE inhibitors].
Topics: Animals; Clinical Trials as Topic; Depression, Chemical; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Humans; Oxidative Stress; Pyridoxamine; Thiadiazoles; Thiamine; Thiazoles; Thiazolidines | 2005 |
[Development of therapeutic agents for diabetic neuropathies].
Topics: Aldehyde Reductase; Antioxidants; C-Peptide; Diabetic Neuropathies; Drug Design; Enzyme Inhibitors; Genetic Therapy; Glycation End Products, Advanced; Hedgehog Proteins; Humans; Indoles; Maleimides; Nerve Growth Factor; Oxidative Stress; Polymers; Protein Kinase C; Rhodanine; Thiadiazoles; Thiamine; Thiazoles; Thiazolidines; Trans-Activators; Vascular Endothelial Growth Factor A | 2005 |
[Prophylactic and therapeutic application of thiamine (vitamin B1)--a new point of view].
Topics: Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus; Diabetic Angiopathies; Humans; Pain; Rats; Thiamine; Thiamine Deficiency | 2006 |
Diabetic neuropathy: new strategies for treatment.
Topics: Aldehyde Reductase; Amines; Analgesics; Anticonvulsants; Antidepressive Agents; Antioxidants; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Pregabalin; Thiamine; Thioctic Acid; Thiophenes | 2008 |
Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications.
Topics: Animals; Clinical Trials as Topic; Diabetes Complications; Glucose; Humans; Hypoglycemic Agents; Intracellular Space; Models, Biological; Thiamine | 2008 |
The multifaceted therapeutic potential of benfotiamine.
Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypoglycemic Agents; Thiamine | 2010 |
[Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy].
Topics: Adjuvants, Immunologic; Antioxidants; Blood Vessels; Diabetic Neuropathies; Hexosamines; Humans; Oxidative Stress; Polymers; Protein Kinase C; Risk Factors; Thiamine; Thioctic Acid | 2010 |
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Enzyme Inhibitors; Evidence-Based Medicine; Female; Glycation End Products, Advanced; Guanidines; Humans; Hyperglycemia; Male; Pyridoxamine; Thiamine; Thiazoles; Treatment Outcome | 2013 |
[A relationship between analgesic and neurotropic effects by the example of milgamma].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cytochrome P-450 Enzyme System; Diabetic Neuropathies; Drug Synergism; Drug Therapy, Combination; Glucose; Glycation End Products, Advanced; Glycosylation; Humans; Neuralgia; Neuroprotective Agents; Pain Measurement; Randomized Controlled Trials as Topic; Thiamine; Treatment Outcome; Vitamin B Complex | 2012 |
Vitamin B and its derivatives for diabetic kidney disease.
Topics: Albuminuria; Diabetic Nephropathies; Folic Acid; Humans; Pyridoxamine; Randomized Controlled Trials as Topic; Selection Bias; Thiamine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins | 2015 |
Advances in the management of diabetic neuropathy.
Topics: Adjuvants, Immunologic; Amines; Anticonvulsants; Antidepressive Agents; Antioxidants; Cardiovascular Diseases; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Drug Therapy, Combination; Duloxetine Hydrochloride; Evidence-Based Medicine; Gabapentin; gamma-Aminobutyric Acid; Humans; Pregabalin; Randomized Controlled Trials as Topic; Thiamine; Thioctic Acid; Treatment Outcome | 2017 |
Therapeutic potential of benfotiamine and its molecular targets.
Topics: Animals; Diabetic Angiopathies; Humans; Signal Transduction; Thiamine | 2018 |
Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Humans; Neuroprotection; Neuroprotective Agents; Thiamine | 2021 |
Therapeutic potential of vitamin B
Topics: COVID-19 Drug Treatment; Diabetes Mellitus; Humans; Thiamine; Vitamins | 2022 |
Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases.
Topics: Animals; Coenzymes; Humans; Neurodegenerative Diseases; Thiamine; Thiamine Pyrophosphate | 2023 |
38 trial(s) available for benphothiamine and thiamine
| Article | Year |
|---|---|
A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.
Topics: Administration, Oral; Aged; Capsules; Diabetic Neuropathies; Double-Blind Method; Drug Combinations; Female; Glycated Hemoglobin; Humans; Male; Median Nerve; Middle Aged; Neural Conduction; Perception; Peroneal Nerve; Pyridoxine; Sensory Thresholds; Thiamine; Time Factors; Vibration; Vitamin B 12 | 1996 |
[Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation].
Topics: Adult; Alcoholism; Cytidine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Peripheral Nervous System Diseases; Pyridoxine; Thiamine; Treatment Outcome; Uridine | 1996 |
Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate.
Topics: Adult; Area Under Curve; Biological Availability; Double-Blind Method; Erythrocytes; Female; Humans; Male; Thiamine | 1997 |
Therapeutic efficacy of "Milgamma" in patients with painful diabetic neuropathy.
Topics: Adult; Aged; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Pain; Thiamine; Vitamin B 12; Vitamin B Complex | 1997 |
Comparative bioavailability of various thiamine derivatives after oral administration.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Fursultiamin; Half-Life; Humans; Middle Aged; Thiamine; Transketolase | 1998 |
[Diabetic polyneuropathy treatment by milgamma-100 preparation].
Topics: Adult; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Pyridoxine; Thiamine; Treatment Outcome | 1998 |
Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy.
Topics: Adult; Aged; Blood Glucose; Chelating Agents; Cholesterol; Diabetic Neuropathies; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Thiamine; Triglycerides | 1999 |
Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD).
Topics: Chromatography, High Pressure Liquid; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Thiamine; Thiamine Monophosphate | 1999 |
High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine.
Topics: Administration, Oral; Adult; Area Under Curve; Erythrocytes; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phosphorylation; Renal Dialysis; Thiamine; Thiamine Pyrophosphate; Transketolase | 2000 |
[Bendotiamine efficacy in alcoholic polyneuropathy therapy].
Topics: Adjuvants, Immunologic; Adult; Alcoholic Neuropathy; Chronic Disease; Humans; Male; Severity of Illness Index; Thiamine | 2001 |
[Milgamma in the treatment of chronic neurosensory hypoacusis].
Topics: Adjuvants, Immunologic; Adult; Aged; Chronic Disease; Hearing Loss, Sensorineural; Humans; Middle Aged; Thiamine; Vitamin B 6 | 2004 |
Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study).
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pain; Placebos; Severity of Illness Index; Thiamine; Treatment Outcome | 2005 |
[Neurometabolic therapy of diabetic neuropathy].
Topics: Adjuvants, Immunologic; Analgesics, Non-Narcotic; Antioxidants; Blood Glucose; Carbamazepine; Diabetic Neuropathies; Drug Therapy, Combination; Follow-Up Studies; Humans; Middle Aged; Pain; Pentoxifylline; Picolines; Thiamine; Thioctic Acid; Treatment Outcome; Vasodilator Agents | 2006 |
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
Topics: Adjuvants, Immunologic; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypertriglyceridemia; Laser-Doppler Flowmetry; Microcirculation; Middle Aged; Oxidative Stress; Thiamine; Vascular Cell Adhesion Molecule-1; Vascular Diseases | 2006 |
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathies; Diclofenac; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Lipids; Male; Meloxicam; Middle Aged; Neuralgia; Pentoxifylline; Selective Serotonin Reuptake Inhibitors; Thiamine; Thiazines; Thiazoles; Thioctic Acid; Thiophenes; Time; Vitamin B 12 | 2007 |
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study.
Topics: Adjuvants, Immunologic; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos; Safety; Sensory Thresholds; Thiamine | 2008 |
Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients.
Topics: Aged; Antimutagenic Agents; Cell Separation; Cells, Cultured; Diabetic Nephropathies; DNA Damage; Female; Ferric Compounds; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lymphocytes; Male; Micronucleus Tests; Microscopy, Fluorescence; Middle Aged; Oxidation-Reduction; Pilot Projects; Prospective Studies; Renal Dialysis; Single-Blind Method; Thiamine; Transketolase | 2008 |
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Glycation End Products, Advanced; Hexosamines; Humans; Hyperglycemia; Intramolecular Oxidoreductases; Male; Oxidative Stress; Thiamine; Thioctic Acid; Time Factors; Treatment Outcome | 2008 |
[Structural and functional changes of arterial vessels in patients with ischemic heart disease and metabolic syndrome].
Topics: Adult; Body Mass Index; Coronary Vessels; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Myocardial Ischemia; Thiamine; Ultrasonography; Vasoconstriction; Vasodilation | 2009 |
[Correction of metabolic disturbances in patients with stable effort angina and metabolic syndrome].
Topics: Adjuvants, Immunologic; Adult; Angina Pectoris; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Lipids; Male; Metabolic Syndrome; Middle Aged; Thiamine; Treatment Outcome | 2009 |
[Vitamin B complex (milgamma) in the treatment of vertebrogenic lumbosacral radiculopathy].
Topics: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Diclofenac; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lumbosacral Plexus; Male; Pain Measurement; Radiculopathy; Thiamine; Time Factors; Treatment Outcome | 2009 |
A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy.
Topics: Adjuvants, Immunologic; Adult; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Drug Therapy, Combination; Female; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney Tubules; Male; Membrane Glycoproteins; Middle Aged; Placebos; Receptors, Virus; Thiamine | 2010 |
The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Biomarkers; Diabetes Mellitus, Type 1; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Peripheral Nerves; Thiamine; Young Adult | 2012 |
Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.
Topics: Aged; Biomarkers; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endothelial Cells; Endothelium; Female; Glycation End Products, Advanced; Humans; Inflammation; Inflammation Mediators; Male; Middle Aged; Thiamine; Treatment Outcome | 2012 |
Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Blood Sedimentation; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Osteoarthritis; Pain Measurement; Pyridoxamine; Thiamine; Treatment Outcome; Vitamin B 12; Walking | 2013 |
[Neuropathy pain: tactic of treatment].
Topics: Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Thiamine; Treatment Outcome; Ukraine | 2012 |
A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes.
Topics: Adult; Aged; Antioxidants; Autonomic Pathways; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Endothelium, Vascular; Fasting; Female; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Pilot Projects; Postprandial Period; Thiamine | 2013 |
Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment.
Topics: Adult; Aged; Chelating Agents; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fluorescence; Glycation End Products, Advanced; Humans; Hyperglycemia; Male; Middle Aged; Postprandial Period; Reproducibility of Results; Skin; Thiamine | 2013 |
Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence.
Topics: Adult; Alcoholism; Algorithms; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Female; Humans; Longitudinal Studies; Male; Middle Aged; Sex Characteristics; Thiamine; Thiamine Deficiency; Treatment Outcome; Young Adult | 2013 |
Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride.
Topics: Administration, Oral; Adult; Biological Availability; Cross-Over Studies; Female; Hippurates; Humans; Male; Thiamine; Young Adult | 2014 |
Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity.
Topics: Adult; Alcoholism; Depression; Double-Blind Method; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Thiamine; Young Adult | 2015 |
Comparative Pharmacokinetic Analysis of Thiamine and Its Phosphorylated Metabolites Administered as Multivitamin Preparations.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Fursultiamin; Humans; Male; Therapeutic Equivalency; Thiamine; Young Adult | 2016 |
Randomized open-label trial of baclofen for relapse prevention in alcohol dependence.
Topics: Adult; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Craving; GABA-B Receptor Agonists; Humans; Middle Aged; Motivational Interviewing; Secondary Prevention; Thiamine; Time Factors; Treatment Outcome | 2017 |
Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Topics: Acetylcarnitine; Adult; Angelica; Berberine Alkaloids; Caffeine; Chronic Pain; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Glutamates; Humans; Hydrochloric Acid; Male; Middle Aged; Pain Management; Plant Bark; Plant Extracts; Plant Roots; Salix; Sex Factors; Thiamine; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin D; Vitamins; Young Adult | 2020 |
Treatment with benfotiamine in patients with diabetic sensorimotor polyneuropathy: A double-blind, randomized, placebo-controlled, parallel group pilot study over 12 months.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Double-Blind Method; Humans; Pilot Projects; Polyneuropathies; Thiamine | 2020 |
Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Brain; Cognitive Dysfunction; Disease Progression; Ethylene Glycols; Female; Fluorodeoxyglucose F18; Glycation End Products, Advanced; Humans; Male; Positron-Emission Tomography; Radiopharmaceuticals; Thiamine; Treatment Outcome | 2020 |
Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects.
Topics: Administration, Oral; Adolescent; Adult; Double-Blind Method; Drug Tolerance; Female; Healthy Volunteers; Humans; Male; Middle Aged; Thiamine; Young Adult | 2021 |
BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Humans; Polyneuropathies; Quality of Life; Thiamine | 2022 |
92 other study(ies) available for benphothiamine and thiamine
| Article | Year |
|---|---|
Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative.
Topics: Adult; Biological Availability; Erythrocytes; Humans; Male; Solubility; Thiamine; Transketolase; Water | 1991 |
[Physical work capacity in diabetes mellitus under treatment].
Topics: Adult; Diabetes Mellitus; Drug Combinations; Exercise Test; Female; Humans; Inosine Diphosphate; Pyridoxal Phosphate; Thiamine; Work Capacity Evaluation | 1989 |
New oral dosage form for elderly patients. II. Release behavior of benfotiamine from silk fibroin gel.
Topics: Adjuvants, Immunologic; Administration, Oral; Aging; beta-Cyclodextrins; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Cyclodextrins; Dosage Forms; Fibroins; Gels; Humans; Mastication; Solubility; Thiamine | 1995 |
Excretion of intracorporeal cadmium with S-benzoylthiamin monophosphate.
Topics: Adult; Animals; Cadmium; Chelating Agents; Hair; Humans; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Middle Aged; Thiamine | 1995 |
A 6-month-old girl with cardiomyopathy who nearly died.
Topics: Adjuvants, Immunologic; Cardiomyopathy, Dilated; Female; Humans; Infant; Injections, Intramuscular; Thiamine | 1997 |
[The effectiveness of the neurotropic agents: benfotiamin combinations].
Topics: Adjuvants, Immunologic; Diabetic Neuropathies; Humans; Thiamine | 1995 |
Comparative autoradiographic investigations on the tissue distribution of benfotiamine versus thiamine in mice.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Autoradiography; Injections, Intravenous; Male; Mice; Thiamine; Tissue Distribution | 1998 |
Biokinetic parameters and metabolism of S-benzoylthiamine-O-monophosphate.
Topics: Humans; Kinetics; Male; Thiamine; Tissue Distribution | 2000 |
Effect of high-dosed thiamine hydrochloride and S-benzoyl-thiamine-O-monophosphate on thiamine-status after chronic ethanol administration.
Topics: Animals; Ethanol; Male; Nutritional Status; Rats; Rats, Wistar; Thiamine; Thiamine Deficiency; Thiamine Pyrophosphate | 2000 |
[Diabetic neuropathy].
Topics: Acupuncture Therapy; Adjuvants, Immunologic; Antioxidants; Combined Modality Therapy; Diabetic Neuropathies; Humans; Lipid Peroxidation; NAD; NADP; Nitric Oxide Synthase; Paresthesia; Severity of Illness Index; Thiamine; Thioctic Acid; Treatment Outcome | 2000 |
Bioavailability of water- and lipid-soluble thiamin compounds in broiler chickens.
Topics: Animals; Biological Availability; Chickens; Chromatography, High Pressure Liquid; Erythrocytes; Lipids; Male; Solubility; Thiamine; Transketolase; Water | 2000 |
[Chronic alcohol abuse. Benfotiamine in alcohol damage is a must].
Topics: Alcoholic Neuropathy; Alcoholism; Humans; Thiamine; Treatment Outcome; Workplace | 2001 |
Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Glycosylation; Lysine; Male; Neural Conduction; Oxidation-Reduction; Peripheral Nerves; Rats; Rats, Wistar; Reference Values; Thiamine; Time Factors | 2001 |
Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose.
Topics: Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Fluorescence; Glucose; Glycation End Products, Advanced; Humans; Thiamine | 2001 |
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Enzyme Activation; Glucose; Glycation End Products, Advanced; Humans; Hyperglycemia; Male; NF-kappa B; Protein Kinase C; Random Allocation; Rats; Rats, Wistar; Retina; Thiamine; Transketolase; Uridine Diphosphate N-Acetylglucosamine | 2003 |
Vitamin B1 blocks damage caused by hyperglycemia.
Topics: Aging; Animals; Cattle; Diabetic Angiopathies; Glucose Intolerance; Glycation End Products, Advanced; Humans; Hyperglycemia; Rats; Thiamine; Transketolase | 2003 |
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.
Topics: Albuminuria; Animals; Chelating Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Male; Pentose Phosphate Pathway; Rats; Rats, Sprague-Dawley; Thiamine; Transketolase | 2003 |
Action of S-benzoylthiamine monophosphate on yeast.
Topics: Saccharomyces cerevisiae; Thiamine; Yeast, Dried; Yeasts | 1962 |
[Oral benfotiamine therapy. Thus you protect the nerves of diabetic patients].
Topics: Administration, Oral; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination; Humans; Placebos; Prodrugs; Pyridoxine; Thiamine; Time Factors; Vitamin B 12; Vitamin B 6 | 2004 |
[Diabetes mellitus. Retinal lesions should not exist!].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Activation; Glycated Hemoglobin; Prodrugs; Rats; Thiamine; Time Factors; Transketolase | 2004 |
High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Complications; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Glycosylation; Hyperlipidemias; Rats; Thiamine | 2005 |
High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Heart Ventricles; Male; Mice; Muscle Cells; Myocardial Contraction; Streptozocin; Thiamine; Treatment Outcome; Ventricular Dysfunction, Left | 2006 |
Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha.
Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glutathione; Glutathione Disulfide; Glycation End Products, Advanced; Male; Mice; Oxidative Stress; Protein Carbonylation; Thiamine; Thromboplastin; Tumor Necrosis Factor-alpha | 2006 |
Benfotiamine relieves inflammatory and neuropathic pain in rats.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Forelimb; Formaldehyde; Inflammation; Injections, Subcutaneous; Ligation; Neuralgia; Rats; Rats, Wistar; Spinal Nerves; Thiamine | 2006 |
Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Body Weight; Caspase 3; Caspase Inhibitors; Caspases; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dietary Supplements; Endothelial Cells; Enzyme Activation; Hemodynamics; Immunohistochemistry; Ischemia; Male; Mice; Mice, Inbred Strains; Muscle, Skeletal; Neovascularization, Physiologic; Oxidative Stress; Proto-Oncogene Proteins c-akt; Random Allocation; Stem Cells; Thiamine | 2006 |
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Glucose; Homeostasis; Humans; Hyperglycemia; Pericytes; Polymers; Reactive Oxygen Species; Retina; Reverse Transcriptase Polymerase Chain Reaction; Sorbitol; Thiamine; Transketolase; Umbilical Cord | 2006 |
Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling.
Topics: Androstadienes; Cell Differentiation; Cell Division; Cells, Cultured; Endothelial Cells; Forkhead Transcription Factors; Glucose; Humans; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Stem Cells; Thiamine; Wortmannin | 2006 |
Evaluating thiamine deficiency in patients with diabetes.
Topics: Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Thiamine; Thiamine Deficiency; Transketolase | 2006 |
Benfotiamine. Monograph.
Topics: Alcoholic Neuropathy; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Humans; Renal Insufficiency, Chronic; Thiamine | 2006 |
Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method.
Topics: Adiponectin; Analysis of Variance; Body Mass Index; Chelating Agents; Cooking; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Food Handling; Hot Temperature; Humans; Hypoglycemic Agents; Male; Middle Aged; Postprandial Period; Thiamine | 2007 |
Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives.
Topics: Animals; Cell Line, Tumor; Lipids; Male; Mice; Mice, Inbred C57BL; Solubility; Structure-Activity Relationship; Thiamine | 2008 |
Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Chelating Agents; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endothelium, Vascular; Fenofibrate; Humans; Hypolipidemic Agents; Lisinopril; Oxidative Stress; Proteinuria; Rats; Rats, Wistar; Superoxides; Thiamine; Thiobarbituric Acid Reactive Substances; Vascular Diseases; Vasodilation | 2009 |
Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Aqueous Humor; Cyclooxygenase 2; Cytokines; Escherichia coli; Leukocytes; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Lew; Thiamine; Uveitis | 2009 |
Schlafen 3, a novel gene, regulates colonic mucosal growth during aging.
Topics: Aging; Animals; Gene Expression Profiling; Gene Expression Regulation; HCT116 Cells; Humans; Intestinal Mucosa; Male; Phosphoinositide-3 Kinase Inhibitors; Proteins; Rats; Rats, Inbred F344; Thiamine | 2009 |
Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Line; Cells, Cultured; Diabetic Retinopathy; DNA Fragmentation; Gene Expression Regulation; Glucose; Humans; Hyperglycemia; In Situ Nick-End Labeling; Models, Biological; Osmotic Pressure; Pericytes; Proto-Oncogene Proteins c-bcl-2; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity; Statistics, Nonparametric; Thiamine; Time Factors; Tumor Suppressor Protein p53 | 2009 |
Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cytoprotection; Diabetic Retinopathy; DNA Fragmentation; Endothelial Cells; Extracellular Matrix; Gene Expression Regulation; Glucose; Humans; Hyperglycemia; Pericytes; Retinal Vessels; RNA, Messenger; Species Specificity; Thiamine | 2009 |
The defensive effect of benfotiamine in sodium arsenite-induced experimental vascular endothelial dysfunction.
Topics: Animals; Arsenites; Endothelium, Vascular; Enzyme Inhibitors; Microscopy, Electron, Scanning; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Sodium Compounds; Thiamine; Thiobarbituric Acid Reactive Substances; Vasodilation | 2010 |
[Treatment of neuropathies].
Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Amines; Analgesics; Antioxidants; Capsaicin; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Polyneuropathies; Pregabalin; Sensory System Agents; Thiamine; Thioctic Acid; Thiophenes | 2010 |
Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Blood Flow Velocity; Blotting, Western; Carrier Proteins; Cells, Cultured; Chromones; Diabetes Mellitus, Experimental; Diastole; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart Failure; Immunohistochemistry; Mice; Microfilament Proteins; Morpholines; Oxidative Stress; Proto-Oncogene Proteins c-pim-1; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Thiamine; Up-Regulation | 2010 |
Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Line; Cytochromes c; Cytoprotection; Cytotoxicity, Immunologic; Enzyme Activation; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Potential, Mitochondrial; Mice; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Thiamine | 2010 |
Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes.
Topics: Adjuvants, Immunologic; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Kidney Glomerulus; Male; Mass Spectrometry; Models, Biological; Oxidative Stress; Proteins; Rats; Rats, Sprague-Dawley; Retina; Thiamine; Vitamin B Complex | 2010 |
Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Cortex; Cognition; Cognition Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Fursultiamin; Glycogen Synthase Kinases; Isoenzymes; Maze Learning; Memory; Mice; Mice, Transgenic; Phosphorylation; Plaque, Amyloid; Presenilin-1; Swimming; tau Proteins; Thiamine | 2010 |
Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response.
Topics: Animals; Blotting, Western; Chelating Agents; Echocardiography; Glucosephosphate Dehydrogenase; Male; Mice; Microscopy, Fluorescence; Myocardial Infarction; Neurotransmitter Agents; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiamine | 2010 |
[Diabetic neuropathies and angiopathies. Compensating for thiamine deficiency].
Topics: Adjuvants, Immunologic; Diabetic Angiopathies; Diabetic Neuropathies; Humans; Thiamine; Thiamine Deficiency | 2010 |
PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine.
Topics: Analysis of Variance; Animals; Aorta; Blotting, Western; Cattle; Cell Death; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Cells; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Protein Phosphatase 2; Rats; Rats, Inbred Lew; RNA, Small Interfering; Thiamine; Transfection | 2010 |
Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis.
Topics: Albuminuria; Animals; Fibrosis; Glycation End Products, Advanced; Kidney; Male; Peritoneal Dialysis; Peritoneum; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiamine; Transketolase; Uremia; Vascular Endothelial Growth Factor A | 2011 |
[Sensorineural hearing loss: New prospects for therapy].
Topics: Adjuvants, Immunologic; Administration, Oral; Aged; Audiometry; Disease Progression; Dose-Response Relationship, Drug; Follow-Up Studies; Hearing; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Humans; Middle Aged; Retrospective Studies; Thiamine; Treatment Outcome | 2011 |
[Prevention of complications in diabetes mellitus. Interdisciplinary collaboration to control sequelae].
Topics: Adjuvants, Immunologic; Animals; Cooperative Behavior; Cross-Sectional Studies; Diabetes Complications; Diabetic Angiopathies; Diabetic Neuropathies; Germany; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incidence; Interdisciplinary Communication; Thiamine | 2011 |
Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Adhesion; Cell Death; Cell Line; Cyclooxygenase 2; Dinoprostone; Epoprostenol; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Inflammation; Leukotrienes; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Protein-Lysine 6-Oxidase; Signal Transduction; Thiamine; Thromboxane B2 | 2012 |
Antinociceptive interaction between benfotiamine and resveratrol in capsaicin-induced licking.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Mice, Inbred ICR; Resveratrol; Stilbenes; Thiamine | 2009 |
Inhibition of macrophage oxidative stress prevents the reduction of ABCA-1 transporter induced by advanced glycated albumin.
Topics: Animals; Antioxidants; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cells, Cultured; Glycation End Products, Advanced; Guanidines; Humans; Macrophages; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Serum Albumin; Serum Albumin, Human; Thiamine | 2012 |
Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Brachial Artery; C-Reactive Protein; Disability Evaluation; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; India; Linear Models; Male; Middle Aged; Multivariate Analysis; Pyridoxamine; Severity of Illness Index; Surveys and Questionnaires; Thiamine; Time Factors; Treatment Outcome; Vasodilation; Vitamin B 12; Vitamin B Complex; Young Adult | 2012 |
[Cochleovestibular disorders: approaches to diagnostics and treatment].
Topics: Adjuvants, Immunologic; Adult; Cochlear Diseases; Female; Humans; Injections, Intramuscular; Male; Neuroprotective Agents; Recovery of Function; Thiamine; Treatment Outcome; Vestibular Diseases; Vestibular Function Tests; Vestibule, Labyrinth; Vestibulocochlear Nerve; Vestibulocochlear Nerve Diseases; Vitamin B Complex | 2011 |
Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment.
Topics: Apoptosis; Cell Communication; Cell Proliferation; Cells, Cultured; Coculture Techniques; Diabetic Retinopathy; Endothelial Cells; Glucose; Humans; Microvessels; Models, Biological; Pericytes; Retinal Vessels; Thiamine | 2012 |
[The importance of the pharmaceutical form and the routes of administration of B-group vitamins for the efficacious treatment of neurosensorial hearing loss].
Topics: Adult; Biopharmaceutics; Cochlear Nerve; Hearing Loss, Sensorineural; Humans; Male; Nerve Regeneration; Riboflavin; Thiamine; Treatment Outcome; Vitamin B Complex | 2012 |
Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose.
Topics: Amyloid beta-Peptides; Cell Survival; Glucose; Glycogen Synthase Kinase 3; HEK293 Cells; Humans; Thiamine | 2012 |
Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes.
Topics: Animals; Antigens, CD; Antigens, Ly; Apoptosis; Biomarkers; Blood Glucose; Cell Proliferation; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endoglin; Flow Cytometry; Glucosephosphate Dehydrogenase; Glycation End Products, Advanced; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Membrane Proteins; Mice; Myocytes, Cardiac; Oxidative Stress; Pentose Phosphate Pathway; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-pim-1; Receptors, Cell Surface; RNA Interference; Signal Transduction; Stem Cells; Superoxides; Thiamine; Transfection; Transketolase | 2013 |
Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.
Topics: Acid Phosphatase; Administration, Oral; Analgesics; Animals; Ganglia, Spinal; Male; Mice; Mice, Knockout; Neurons, Afferent; Phosphorylation; Protein Tyrosine Phosphatases; Spinal Cord; Substrate Specificity; Thiamine | 2012 |
[The role of neurotropic therapy in the treatment of acute sensorineural impairment of hearing following a viral infection].
Topics: Acute Disease; Adjuvants, Immunologic; Adult; Biological Availability; Cochlear Nerve; Drug Monitoring; Drug Therapy, Combination; Ear, Inner; Female; Hearing Loss, Sensorineural; Hearing Tests; Humans; Injections, Intramuscular; Male; Middle Aged; Neuroprotective Agents; Thiamine; Treatment Outcome; Virus Diseases | 2012 |
[The optimization of the treatment of the vertebrogenic pain syndrome: neurotrophic treatment potentiates the effect of nonsteroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Drug Therapy, Combination; Humans; Thiamine; Vitamin B 12; Vitamin B Complex | 2012 |
Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.
Topics: Azaserine; Diabetes Mellitus; Glucose; Glycolysis; Hep G2 Cells; Hexosamines; Humans; Hyperglycemia; Membrane Potential, Mitochondrial; Mitochondria; NAD; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Protein Carbonylation; Reactive Oxygen Species; Thiamine | 2013 |
Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration.
Topics: Alcoholic Intoxication; Animals; Liver; Male; Rats; Rats, Wistar; Thiamine; Vitamins | 2013 |
Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats.
Topics: Animals; Antioxidants; Aryldialkylphosphatase; Catalase; Cisplatin; DNA Damage; Glutathione Peroxidase; Glutathione Reductase; Kidney; Malondialdehyde; Oxidative Stress; Protective Agents; Rats; Reactive Oxygen Species; Superoxide Dismutase; Thiamine | 2013 |
Antiglycation activity of thiamin-HCl and benfotiamine in diabetic condition.
Topics: Blood Glucose; Chelating Agents; Diabetes Mellitus; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Glycosylation; Humans; Thiamine; Vitamin B Complex | 2012 |
[The effect of long-chain polyunsaturated higher ω-3 fatty acids, benfotiamine and α-lipoic acid on the lipid metabolism in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy].
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Glycated Hemoglobin; Humans; Lipid Metabolism; Male; Middle Aged; Thiamine; Thioctic Acid; Triglycerides | 2013 |
The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes.
Topics: Analgesics; Analgesics, Opioid; Animals; Body Weight; Diabetes Mellitus, Experimental; Fentanyl; Formaldehyde; Hot Temperature; Male; Mice; Nociception; Pain Measurement; Reaction Time; Receptors, Opioid, mu; Thiamine | 2014 |
Annexin V imaging detects diabetes-accelerated apoptosis and monitors the efficacy of benfotiamine treatment in ischemic limbs of mice.
Topics: Animals; Annexin A5; Apoptosis; Cell Line, Tumor; Diabetes Mellitus, Experimental; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Mice; Mice, Inbred C57BL; Streptavidin; Thiamine | 2014 |
A novel spectral resolution and simultaneous determination of multicomponent mixture of Vitamins B1, B6, B12, Benfotiamine and Diclofenac in tablets and capsules by derivative and MCR-ALS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, High Pressure Liquid; Diclofenac; Least-Squares Analysis; Limit of Detection; Multivariate Analysis; Spectrophotometry; Tablets; Thiamine; Vitamin B 12; Vitamin B 6; Vitamins | 2015 |
Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Cell Survival; Cyclooxygenase 2; Cytokines; Cytoskeleton; HSP70 Heat-Shock Proteins; Lipopolysaccharides; Mice; Microglia; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiamine | 2015 |
Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Cycle; Cell Proliferation; Chelating Agents; Humans; Leukemia, Myeloid, Acute; Phosphorylation; Thiamine; Tumor Cells, Cultured | 2015 |
Pharmacokinetics of the transdermal delivery of benfotiamine.
Topics: Administration, Cutaneous; Animals; Diabetic Neuropathies; Drug Delivery Systems; Guinea Pigs; Male; Muscle, Skeletal; Peripheral Nervous System Diseases; Skin; Thiamine | 2016 |
Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication.
Topics: Alcoholic Intoxication; Animals; Disease Models, Animal; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Wistar; Thiamine | 2016 |
Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease.
Topics: Adjuvants, Immunologic; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Humans; Longitudinal Studies; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiamine; Thiazoles | 2016 |
Chromatographic Analysis of a Multicomponent Mixture of B1, B6, B12, Benfotiamine, and Diclofenac; Part I: HPLC and UPLC Methods for the Simultaneous Quantification of These Five Components in Tablets and Capsules.
Topics: Capsules; Chromatography, High Pressure Liquid; Diclofenac; Tablets; Thiamine; Vitamin B Complex | 2016 |
Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice.
Topics: Animals; Avoidance Learning; Brain; Cognition Disorders; Conditioning, Psychological; Disease Models, Animal; Extinction, Psychological; Fear; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Stress, Psychological; Swimming; Thiamine; Time Factors; Vitamin B Complex | 2017 |
Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Glycogen Synthase Kinase 3; Hippocampus; Male; Mice, Inbred C57BL; Neurogenesis; Thiamine; Thiamine Pyrophosphate | 2017 |
Effects of benfotiamine and coenzyme Q10 on kidney damage induced gentamicin.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Gentamicins; Kidney; Male; Mice; Oxidative Stress; Random Allocation; Rats, Wistar; Thiamine; Ubiquinone | 2017 |
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.
Topics: Amyloid beta-Peptides; Animals; Antioxidant Response Elements; Brain; Disease Models, Animal; Humans; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Transgenic; Neuroprotection; NF-E2-Related Factor 2; Oxidative Stress; Protein Aggregation, Pathological; Signal Transduction; tau Proteins; Tauopathies; Thiamine | 2018 |
Ortner's syndrome after cryoballoon ablation.
Topics: Adjuvants, Immunologic; Atrial Fibrillation; Catheter Ablation; Cryosurgery; Humans; Middle Aged; Pulmonary Veins; Syndrome; Thiamine; Vocal Cord Paralysis | 2019 |
Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice.
Topics: Aggression; Animals; Antioxidants; Brain; Depression; Male; Mice, Inbred BALB C; Neuronal Plasticity; Oxidative Stress; Receptors, AMPA; Receptors, Serotonin; Thiamine; Ultrasonic Waves | 2019 |
Neonatal diabetes mellitus: remission induced by novel therapy.
Topics: Administration, Oral; Anemia, Megaloblastic; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Frameshift Mutation; Glycated Hemoglobin; Hearing Loss, Sensorineural; Humans; Thiamine; Thiamine Deficiency; Treatment Outcome | 2019 |
Benfotiamine supplementation prevents oxidative stress in anterior tibialis muscle and heart.
Topics: Animals; Dietary Supplements; Heart; Liver; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Oxidative Stress; Physical Conditioning, Animal; Sedentary Behavior; Thiamine | 2019 |
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Confidence Intervals; Dietary Supplements; Female; Humans; Inhibitory Concentration 50; Intracellular Space; Mice, Nude; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Thiamine; Thiamine Pyrophosphate | 2020 |
Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Biomarkers; Cardiotoxins; Disease Models, Animal; Electrocardiography; Enzyme Inhibitors; Humans; Inflammation Mediators; Isoproterenol; Male; Myocardial Infarction; Myocardium; NADPH Oxidases; Oxidative Stress; Rats; Rats, Wistar; Thiamine | 2020 |
Benfotiamine Reduces Dendritic Cell Inflammatory Potency.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Dendritic Cells; Inflammation; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Signal Transduction; Thiamine; Tumor Necrosis Factor-alpha | 2021 |
Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration.
Topics: Alzheimer Disease; Animals; Brain; Cognition; Humans; Rats; Thiamine; Thiamine Pyrophosphate | 2020 |
Protective effect of benfotiamine on methotrexate induced gastric damage in rats.
Topics: Animals; Antioxidants; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Thiamine | 2021 |
Implementation of Two Chromatographic Methods for Simultaneous Quantitation of Thioctic Acid, Benfotiamine and Cyanocobalamin.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Reproducibility of Results; Thiamine; Thioctic Acid; Vitamin B 12 | 2021 |
The impact of thiamine deficiency and benfotiamine treatment on Nod-like receptor protein-3 inflammasome in microglia.
Topics: Adjuvants, Immunologic; Animals; Cell Line; Male; Mice; Mice, Inbred C57BL; Microglia; Receptors, Cell Surface; Thiamine; Thiamine Deficiency; Treatment Outcome | 2021 |
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Survival; Citric Acid Cycle; Diabetic Nephropathies; Disease Models, Animal; Female; Glucose; Glycolysis; Humans; Hyperglycemia; Indoles; Mice; Neurons; Poly(ADP-ribose) Polymerases; Primary Cell Culture; Pyruvic Acid; Rats; Schwann Cells; Thiamine | 2021 |
Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer's Disease.
Topics: Alzheimer Disease; Biomarkers; Case-Control Studies; Chromatography, Liquid; Humans; Lipids; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Pilot Projects; Thiamine | 2021 |
Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Rats; Streptozocin; Thiamine | 2022 |