benidipine has been researched along with dihydropyridines in 221 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.36) | 18.7374 |
| 1990's | 50 (22.62) | 18.2507 |
| 2000's | 101 (45.70) | 29.6817 |
| 2010's | 57 (25.79) | 24.3611 |
| 2020's | 10 (4.52) | 2.80 |
| Authors | Studies |
|---|---|
| Karasawa, A; Kubo, K; Sano, J; Shirakura, S | 2 |
| Karasawa, A; Lefer, AM; Ma, XL; Rochester, JA | 1 |
| Gotoh, Y; Imaizumi, Y; Watanabe, M; Yamamoto, M | 1 |
| Abe, K; Kanazawa, M; Kohzuki, M; Kudo, K; Omata, K; Sato, M; Takeuchi, K; Tsunoda, K; Yasujima, M; Yoshida, K | 3 |
| Gotoh, Y; Imaizumi, Y; Kawai, T; Kumadani, S; Watanabe, M | 1 |
| Ishii, A | 1 |
| Fukui, M; Mizokuchi, M; Shirato, I; Tang, Z; Tomino, Y; Wang, LN | 1 |
| Gomi, T; Goto, A; Hirawa, N; Ikegami, J; Kawabata, Y; Nagoshi, H; Numabe, A; Omata, M; Takeda, T; Uehara, Y | 1 |
| Esato, K; Fujimura, Y; Tsuboi, H | 1 |
| Kato, H; Ozaki, S; Suzuki, S; Takata, Y; Uegomori, T | 1 |
| Ishii, A; Toyama, J | 1 |
| Karasawa, A; Moriyama, T | 1 |
| Deguchi, T; Tanaka, H | 1 |
| Karasawa, A; Kusaka, H; Nomura, H | 2 |
| Kondo, M; Sakane, N; Umekawa, T; Wakabayashi, Y; Yoshida, T | 1 |
| Hara, K; Ito, S; Kanmasse, K; Kawamura, H; Komatsu, K; Maki, M; Mitsubayashi, H; Suzuki, K; Tsukamoto, K; Usui, W | 1 |
| Ide, S; Karasawa, A; Kondoh, M; Satoh, H | 2 |
| Harashima, H; Kajita, J; Kiwada, H; Kobayashi, S | 1 |
| Karasawa, A; Yao, K | 1 |
| Gao, F; Imada, T; Ma, H; Nagata, T; Suzuki, K | 1 |
| Kajita, J; Kobayashi, S; Yoshida, T | 1 |
| Karasawa, A; Kubo, K; Shirakura, S | 1 |
| Kobayashi, H; Kobayashi, S; Magara, H | 1 |
| Dohi, Y; Kojima, M; Sato, K | 1 |
| Abe, K; Kanazawa, M; Kohzuki, M; Yasujima, M; Yoshida, K | 1 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Hara, T; Karasawa, A; Nito, M; Ohta, Y; Sato, H; Yamada, K | 1 |
| Shimamoto, H; Shimamoto, Y | 2 |
| Fukui, M; Shou, I; Takahashi, Y; Tomino, Y; Wang, LN | 1 |
| Chasseaud, LF; Dalrymple, PD; Kobayashi, H; Kobayashi, S; Wood, SG | 1 |
| Kobayashi, K; Kobayashi, N; Kouno, K; Matsuoka, H; Yagi, S | 1 |
| Kobayashi, H; Kobayashi, S | 2 |
| Kakinoki, S; Kitabatake, A; Nomura, A; Takechi, S | 2 |
| Kosaka, N; Uchii, M | 1 |
| Asanuma, H; Hori, M; Kitakaze, M; Kuzuya, T; Minamino, T; Node, K | 1 |
| Honda, M; Kuramochi, T; Maeda, A; Takabatake, T | 1 |
| Hiwada, K; Kohara, K; Muneta, S | 1 |
| Bengtsson, T; Cannon, B; Golozoubova, V; Nedergaard, J; Zhao, J | 1 |
| Horikawa, N; Imabeppu, S; Ishii, K; Kohno, F; Kubo, K; Nakayama, K; Ogawa, T | 1 |
| Hara, K; Higashi, T; Kobayashi, K; Kobayashi, N; Matsuoka, H; Yagi, S; Yanaka, H | 1 |
| Inoue, H; Kagitani, S; Kinuno, H; Takata, M; Tomita, S; Tomoda, F; Yasumoto, K | 1 |
| Kurisu, S; Ozono, R; Teranishi, Y; Tsuru, H; Ueda, A; Yoshimizu, A | 1 |
| Karasawa, A; Kobayashi, S; Kosaka, N; Nito, M; Nomura, H; Sonoda, R; Tanaka, H; Yamaguchi, K | 1 |
| Harano, Y; Hasegawa, M; Kanazawa, A; Suzuki, M | 1 |
| Matsuda, Y; Tsukuda, E | 1 |
| Hoshide, S; Ikeda, U; Kario, K; Mitsuhashi, T; Shimada, K | 1 |
| Funabiki, K; Gohda, T; Shike, T; Shirato, I; Tashiro, K; Tomino, Y | 1 |
| Ina, Y; Nagashima, K; Nishikawa, S; Ohmori, K; Ohno, T; Sato, H; Yao, K | 1 |
| Imai, K; Ina, Y; Kobayashi, S; Nagashima, K; Ohmori, K; Santa, T; Takezawa, K; Tsunoda, M | 1 |
| Imaizumi, Y; Muraki, K; Tokuno, T; Watanabe, M | 1 |
| Dohi, Y; Nakazawa, A; Sato, K; Sugiyama, M; Takase, H; Ueda, R | 1 |
| Akioka, H; Miyazaki, M; Nakajima, O | 1 |
| Bagati, A; Gala, D; Kalke, S; Nair, KG; Shah, BV; Sood, OP | 1 |
| Otsuka, M; Shiraiwa, H; Sugawara, H; Ueki, A | 1 |
| Akashi, T; Harada, M; Hosoya, T; Ikeda, K; Nakagawa, O; Nakao, K; Tojo, K; Tokudome, G | 1 |
| Goto, A; Hayakawa, H; Hirata, Y; Kakoki, M; Kimura, K; Nagata, D; Nishimatsu, H; Omata, M; Suzuki, E | 1 |
| Hara, T; Ishi, A; Shuto, K; Ueno, H | 1 |
| Kawachi, H; Nakamura, T; Obata, JE; Onitsuka, M; Shimada, Y; Shimizu, F; Yoshida, Y | 1 |
| Christopher, TA; Gao, F; Gong, B; Karasawa, A; Lopez, BL; Ma, XL | 1 |
| Hirase, T; Hirata, K; Inoue, N; Kawashima, S; Ozaki, M; Rikitake, Y; Yamashita, T; Yokoyama, M | 1 |
| Saruta, T; Suzuki, H | 1 |
| Kobayashi, N; Kobayashi, T; Matsuoka, H; Mori, Y; Nakano, S; Tsubokou, Y | 1 |
| Abe, Y; Fujisawa, Y; Fukui, T; Kimura, S; Li, F; Nishiyama, A; Rahman, M; Tian, R; Yue, W | 1 |
| Asakura, M; Asanuma, H; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Sakata, Y; Sanada, S; Shinozaki, Y; Tada, M; Takashima, S | 1 |
| Cornélissen, G; Halberg, F; Kubo, Y; Ohkawa, S; Otsuka, K; Shinagawa, M | 1 |
| Kosaka, N; Nishiya, Y; Sugimoto, S; Uchii, M | 1 |
| Fujishima, M; Ibayashi, S; Kitayama, J; Kitazono, T; Ooboshi, H; Takada, J | 1 |
| Fujii, S; Hattori, Y; Jesmin, S; Kitabatake, A; Sakuma, I | 1 |
| Fatema, K; Hirono, O; Kaneko, K; Kubota, I; Nitobe, J; Shiga, R; Takeishi, Y | 1 |
| Iwao, H; Kawano, H; Kim, S; Zhan, Y | 1 |
| Iwao, H; Kim, S; Nakao, T; Namba, M; Zhan, Y | 1 |
| Kimura, R; Kusaka, T; Nakajima, M; Uchida, S; Yamada, S | 1 |
| Imanishi, M; Konishi, Y; Morikawa, T; Okada, N; Okumura, M | 1 |
| Ina, Y; Nagashima, K; Ohmori, K; Ohno, T; Sonoda, R; Yao, K | 1 |
| Asakura, M; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Liao, Y; Minamino, T; Node, K; Ogai, A; Ogita, H; Sanada, S; Takashima, S | 1 |
| Kishimoto, C; Shioji, K; Yuan, Z | 1 |
| Iga, A; Ito, S; Kageyama, N; Katoh, K; Kawano, T; Kusunoki, K; Nakaya, Y; Nakayama, T; Nishikado, A; Nomura, M; Okamoto, H; Saito, K; Sawa, Y; Uemura, E | 1 |
| Date, H; Eto, T; Imamura, T; Ishikawa, T; Kita, T; Matsuo, T; Matsuura, Y; Matsuyama, A; Nagoshi, T | 1 |
| Ina, Y; Ohno, T; Sato, H; Sonoda, R; Suzuki, K; Yao, K | 1 |
| Ina, Y; Ohno, T; Sato, H; Shirakura, S; Suzuki, K; Yao, K | 1 |
| Inomata, K; Tanaka, H | 1 |
| Hidekazu, H; Koji, H; Masanori, S; Mitsuharu, H; Shigefumi, S; Takanobu, A; Takeshi, I; Toshihiko, S; Yasuyuki, B | 1 |
| Kang, W; Kwon, KI; Liu, KH; Shin, JG; Yun, HY | 1 |
| Arai, M; Chen, XH; Fujiwara, H; Lu, C; Minatoguchi, S; Misao, Y; Nagai, H; Takemura, G; Uno, Y; Wang, N | 1 |
| Christopher, TA; Gao, E; Gao, F; Hu, A; Liu, HR; Lopez, BL; Ma, XL; Tao, L; Yan, WL | 1 |
| Dohi, Y; Kojima, M; Sato, K; Taniguchi, M; Ueda, R | 1 |
| Shirakura, S; Yao, K | 1 |
| Hasegawa, K; Matsubara, M | 2 |
| Fukumoto, Y; Ito, A; Shimokawa, H | 1 |
| Hibino, T; Kato, K; Matsubara, T; Suzuki, O; Tani, S; Yokoi, K; Yoneyama, A; Yoshida, T | 1 |
| Inoue, S; Tomino, Y | 1 |
| Nishio, I; Tsuda, K | 1 |
| Cha, IJ; Kang, W; Kwon, KI; Lee, DJ; Liu, KH; Shin, JG; Sunwoo, YE | 1 |
| Chen, MZ; Guo, JX; Jin, WY; Li, HY; Sun, W; Zhang, YZ | 1 |
| Kang, WK; Kwon, KI; Yun, HY | 1 |
| Asakura, M; Asano, Y; Asanuma, H; Hori, M; Kitakaze, M; Liao, Y; Minamino, T; Ogai, A; Takashima, S; Tomoike, H | 1 |
| Iwasaka, T; Nishikawa, M; Nomura, S; Omoto, S; Shouzu, A | 1 |
| Hattori, Y; Jesmin, S; Kitabatake, A; Miyauchi, T; Sakuma, I | 1 |
| Maeda, K; Nakamura, M; Watanabe, T; Yasunari, K; Yoshikawa, J | 1 |
| Aoki, M; Hashiya, N; Makino, H; Miwa, K; Morishita, R; Ogihara, T; Shimizu, H; Yamasaki, K | 1 |
| Hasegawa, K; Matsubara, M; Yao, K | 1 |
| Kang, W; Kwon, KI; Yun, HY; Yun, MH | 1 |
| Hattori, Y; Jesmin, S; Maeda, S; Miyauchi, T; Sakuma, I; Zaedi, S | 1 |
| Arakawa, E; Hasegawa, K | 1 |
| Baba, T; Hashimoto, S; Katoh, T; Midorikawa, S; Sanada, H; Watanabe, T; Yatabe, J; Yatabe, MS | 1 |
| Miki, H; Nagashima, K; Yao, K | 1 |
| Fujita, K; Ina, Y; Kobayashi, H; Kuwabara, T; Maeda, H; Sato, M; Shirakura, S; Yao, K | 1 |
| Eto, T; Kita, T; Kitamura, K; Suzuki, Y | 1 |
| Jesmin, S; Maeda, S; Miyauchi, T; Mowa, CN; Sakuma, I; Zaedi, S | 1 |
| Hosoi, M; Imanishi, M; Konishi, Y; Masada, M; Miura, K; Morikawa, T; Okada, N; Okumura, M; Shintaku, H; Yoshida, Y | 1 |
| Kanai, S; Miyashita, Y; Oyama, T; Sasaki, H; Shirai, K; Yamamura, S | 1 |
| Arakawa, E; Hasegawa, K; Ina, Y; Kohno, H; Ohno, T; Sato, H; Takayama, M; Yao, K | 1 |
| Kamiya, A; Matsuzaki, M; Ogihara, T; Umemoto, S | 1 |
| Hayashi, K; Iigaya, K; Kumagai, H; Onami, T; Takimoto, C | 1 |
| Ikeda, J; Matsubara, M; Yao, K | 2 |
| Arakawa, E; Hasegawa, K; Ina, Y; Matsubara, M; Takada, C; Takayama, M; Yao, K | 1 |
| Akimoto, Y; Daida, H; Suzuki, H; Yokoyama, K | 1 |
| Ando, H; Hasegawa, K; Miyaji, H; Nakanishi, K; Shibata, M; Yao, K | 1 |
| Anazawa, T; Fuji, T; Hirayama, A; Kanmatsuse, K; Kawamata, H; Kushiro, T; Matsumoto, M; Nagao, K; Onikura, M; Sato, Y; Tachibana, E; Tani, S; Watanabe, I | 1 |
| Fujita, H; Harasawa, S; Ichiyama, I; Kanmatsuse, K; Kushiro, T; Oiwa, K; Otsuka, Y; Saito, F; Takahashi, A; Takahashi, N; Uchiyama, T | 1 |
| Araki, S; Fujii, T; Isshiki, K; Kanasaki, M; Kashiwagi, A; Kimura, G; Nishimura, M; Sakaguchi, M; Sugiomoto, T; Uzu, T | 1 |
| Hamada, C; Hosaka, S; Kitamori, N; Sadoshima, T; Sato, M; Takahashi, Y | 1 |
| Cha, IJ; Kim, EY; Kim, H; Kim, HS; Kim, KB; Liu, KH; Seo, KA; Shin, JG; Yoon, YJ | 1 |
| Fuse, E; Kobayashi, H; Kuwabara, T; Mimura, N; Sugiyama, Y; Ushiki, J | 1 |
| Hioki, C; Kawada, T; Kotani, K; Sakane, N; Yoshida, T | 1 |
| Miyaguchi, S; Ota, S; Seino, H; Suzuki, S; Yabe, R; Yamazaki, T | 1 |
| Fujiwara, H; Hattori, A; Hiei, K; Io, K; Kato, T; Kawasaki, M; Matsuo, H; Minatoguchi, S; Morita, N; Nishigaki, K; Noda, T; Ojio, S; Ono, H; Sato, H; Segawa, T; Takemura, G; Tanaka, T; Ueno, K; Watanabe, S | 1 |
| Hayashi, N; Ito, N; Katsuya, T; Ogihara, T; Ohishi, M; Rakugi, H; Shiota, A; Takagi, T; Tatara, Y; Terai, M | 1 |
| Akizuki, O; Ikeda, J; Matsubara, M; Saeki, K; Sasaki, K; Yao, K | 1 |
| Fukushima, H; Kobayashi, N; Matsuoka, H; Ohno, T; Yoshida, K | 1 |
| Akizuki, O; Inayoshi, A; Kitayama, T; Kusaka, H; Matsubara, M; Sasaki, K; Shirakura, S; Yao, K | 1 |
| Fukumoto, Y; Ito, A; Shimokawa, H; Yasuda, S | 1 |
| Tsuda, K | 1 |
| Furuta, K; Hongo, M; Ishizaka, N; Koike, K; Matsuzaki, G; Nagai, R; Saito, K; Sakurai, R | 1 |
| Matsumoto, C; Shiina, K; Tomiyama, H; Yamada, J; Yamashina, A; Yoshida, M | 1 |
| Anazawa, T; Fuji, T; Furuya, S; Hirayama, A; Iida, K; Kawamata, H; Kumabe, T; Matsumoto, M; Nagao, K; Sato, Y; Takahashi, H; Tani, S | 1 |
| Chen, MD; Lin, PY; Song, YM | 1 |
| Arioka, I; Dohi, S; Sakai, K | 1 |
| Chen, XC; Fang, NY; Pan, ZH; Wang, CF; Wang, HY; Wu, H; Zhang, H; Zhang, SH; Zhong, Y | 1 |
| Masai, H; Miwa, Y; Shimizu, M | 1 |
| Abe, M; Maruyama, N; Maruyama, T; Matsumoto, K; Okada, K | 1 |
| Takayama, M; Wada, M; Yao, K | 1 |
| Hoshino, C; Kikuchi, A; Kuriyama, C; Ohta, M; Sato, N; Sugawara, S | 1 |
| Furuta, K; Hongo, M; Ishizaka, N; Koike, K; Matsuzaki, G; Nagai, R; Saito, K; Sakamoto, A; Sakurai, R | 1 |
| Hu, Z; Jiang, B; Li, X; Peng, T; Xia, Q; Yang, X | 1 |
| Dohi, Y; Kimura, G; Miyagawa, K; Nakazawa, A; Sato, K; Sugiura, T; Yamashita, S | 1 |
| Fujiwara, N; Kawagoe, Y; Koide, H; Nakamura, T; Sato, E; Sugaya, T; Ueda, Y; Yamada, S; Yamagishi, S | 1 |
| Aizawa, T; Fujimoto, Y; Ishiwata, S; Matsuno, S; Nakamura, M; Oikawa, Y; Ono, T; Yajima, J | 1 |
| Dong, YF; Fukuda, M; Kataoka, K; Kim-Mitsuyama, S; Nakamura, T; Nako, H; Ogawa, H; Yamamoto, E | 1 |
| Hirayama, K; Kitayama, T; Kosaka, H; Kusaka, H; Matsubara, M; Sasaki, K; Yoda, N | 1 |
| Futenma, A; Imai, H; Kimura, Y; Maeda, K; Miura, N; Suga, N; Yamada, H | 1 |
| Guo, L; Hu, Z; Jiang, B; Li, XH; Pei, F; Peng, T; Song, J; Xia, Q; Yang, XD | 1 |
| Kitakaze, M; Liao, YL; Luo, Q; Xi, F; Xuan, WL | 1 |
| Cheng, XW; Hirashiki, A; Izawa, H; Jin, Z; Kuzuya, M; Murohara, T; Nagata, K; Nishizawa, T; Noda, A; Obata, K; Okumura, K; Sasaki, T; Shi, GP; Takeshita, K | 1 |
| Abe, M; Fujita, T; Maruyama, N; Maruyama, T; Matsumoto, K; Matsumoto, S; Okada, K; Soma, M | 2 |
| Fukumoto, Y; Inoue, Y; Minatoguchi, S; Nishigaki, K; Shimokawa, H; Sueda, S; Urata, H; Yamanouchi, Y; Yasuda, S | 1 |
| Akbayram, S; Akgün, C; Caksen, H; Doğan, M; Geylani, H; Sarı, N; Taşkın, AG | 1 |
| Inagaki, K; Kumagai, I; Makino, H; Miyoshi, T; Nakamura, E; Ogura, T; Otsuka, F; Suzuki, J; Tanabe, K; Tsukamoto, N | 1 |
| Kageyama, S; Saito, I; Saruta, T; Suzuki, H | 2 |
| Funahashi, J; Inayoshi, A; Kusaka, H; Matsubara, M; Sugimoto, Y; Takahashi, S | 1 |
| Fan, W; Qi, W | 1 |
| Abe, K; Eto, T; Higaki, J; Ito, S; Kamiya, A; Kikuchi, K; Matsuoka, H; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Suzuki, H; Suzuki, N; Tei, C; Umemoto, S | 1 |
| Teo, KK | 1 |
| Fukamachi, S; Nakamura, M; Sugita, K; Tokura, Y | 1 |
| Furusho, H; Kaneko, S; Kitano, K; Ohtani, K; Okajima, M; Takamura, M; Takashima, S; Usui, S; Yamamoto, K | 1 |
| Higaki, J; Ito, S; Kamiya, A; Matsuoka, H; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Shimamoto, K; Suzuki, H; Umemoto, S | 2 |
| Shinozaki, K | 1 |
| Gumustas, M; Karadas, N; Ozkan, SA; Sanli, S | 1 |
| Kazama, I; Maruyama, Y; Matsubara, M | 1 |
| Baek, SH; Chae, SC; Cho, MC; Choi, DJ; Ha, JW; Ihm, SH; Jeon, HK; Kim, DS; Kim, KH; Kim, KS; Lim, DS | 1 |
| Tomino, Y | 1 |
| Higaki, J; Ito, S; Kitagawa, K; Matsumoto, M; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Suzuki, H; Umemoto, S | 1 |
| Hu, Y; Wu, G; Xu, K; Xu, M | 1 |
| Minatoguchi, S | 1 |
| Ando, K; Fujita, T; Isshiki, M; Kashihara, N; Nakanishi, T; Nangaku, M; Nishizawa, Y; Nitta, K; Rakugi, H; Shimosawa, T; Takahashi, K; Tomita, K; Yokoyama, H | 1 |
| Kazama, I | 2 |
| Akhtar, M; Akhtar, MS; Ali, J; Ansari, SH; Haque, SE; Hassan, MQ; Najmi, AK | 1 |
| Hirayama, A; Nagao, K; Takahashi, A; Tani, S | 1 |
| Baba, A; Ejima, Y; Endo, Y; Kazama, I; Matsubara, M; Toyama, H | 1 |
| Balcazar, DE; Bellera, CL; Bruno-Blanch, LE; Carrillo, C; Casassa, AF; Gálvez, J; Gavernet, L; Labriola, CA; Palestro, PH; Romano, PS; Talevi, A; Vanrell, MC | 1 |
| Cai, DZ; Liao, JC; Ma, ZP; Zhao, C | 1 |
| Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Umemoto, S | 2 |
| He, GW; Hou, HT; Liu, XC; Marinko, M; Novakovic, A; Wang, J; Wang, ZQ; Yang, Q | 1 |
| Hirayama, A; Kanai, T; Kasamaki, Y; Kunimoto, S; Takayama, T; Yajima, Y; Yoda, S | 1 |
| Akhtar, M; Akhtar, MS; Ali, J; Haque, SE; Hassan, MQ; Najmi, AK | 1 |
| Bisenieks, E; Duburs, G; Gall Troselj, K; Krauze, A; Poikans, J; Velena, A; Zarkovic, N | 1 |
| Endo, T; Gohbara, M; Kimura, K | 1 |
| Dai, B; Lv, J; Mei, C; Wang, Y; Xue, C; Yang, B; Yu, S; Zhao, G; Zhou, C | 1 |
| Arslan Nayki, U; Atakan Al, R; Balci, G; Cankaya, M; Suleyman, B; Suleyman, H; Unlubilgin, E | 1 |
| Kario, K; Kawana, M; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Umemoto, S | 1 |
| Adachi, T; Aonuma, K; Nogami, A; Sato, A | 1 |
| Canbolat, S; Nurullahoglu Atalik, KE | 1 |
| Chien, CM; Nguyen, PTT; Ryu, JY; Shin, JG; Shon, J; Sunwoo, YE | 1 |
| Cai, C; Chen, W; Liu, QH; Shen, J; Wen, N; Yang, Y | 1 |
| Furui, K; Morishima, I; Morita, Y; Takagi, K; Yoshida, R | 1 |
| Alba Soto, CD; Areco, Y; Bellera, CL; Buchholz, B; Carrillo, C; Gelpi, RJ; Kelly, J; Miranda, C; Quarroz Braghini, J; Sbaraglini, ML; Talevi, A | 1 |
| Hayashi, K; Makino, H; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Umemoto, S | 1 |
| Choi, DK; Kim, DK; Kim, JH; Kim, JW; Kwon, OB; Lee, DS; Lee, H; Lee, J; Lee, S; Min, SH; Yu, JH | 1 |
| Abdelsattar, AT; Alamodi, AA; Masoud, AT; Mohammed, OM; Nso, N; Payton, M; Shareef, MA; Sofy, AA | 1 |
| Ding, L; Jiang, P; Li, L; Liu, S; Lu, W; Xu, X; Yang, C; Zhou, P | 1 |
| Fan, L; Wang, B; Wang, H; Wang, Y; Yang, J; Zhang, C | 1 |
| Bender, A; Chen, X; Li, Y; Meng, Q; Yang, J; Zhang, Y | 1 |
| Albayrak, A; Arslan, R; Bayraktar, M; Bekmez, H; Çelik, M; Kaya, Z; Koçak, MN; Tavaci, T; Tekin, E | 1 |
| Altuner, D; Arslan, R; Bedir, F; Çoban, TA; Kocaturk, H; Suleyman, H; Turangezli, Ö | 1 |
| Furui, M; Inagaki, K; Kamei, H; Matsubara, T | 1 |
| Altaysan, AI; Attimarad, M; Balgoname, AA; Chohan, MS; David, M; Kotnal, RB; Molina, EIP; Nair, AB; Shafi, S; Shinu, P; Sreeharsha, N; Venugopala, KN | 1 |
11 review(s) available for benidipine and dihydropyridines
| Article | Year |
|---|---|
[A case of primary aldosteronism presenting hypokalemic myopathy induced by benidipine hydrochloride; a dihydropyridine calcium channel blocker].
Topics: Calcium Channel Blockers; Dihydropyridines; Humans; Hyperaldosteronism; Hypokalemia; Hypokalemic Periodic Paralysis; Male; Middle Aged; Muscular Diseases | 2000 |
Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker.
Topics: Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, T-Type; Clinical Trials as Topic; Diabetic Nephropathies; Dihydropyridines; Drug Evaluation, Preclinical; Endothelial Cells; Heart; Humans; Hypertension; Kidney; Renal Circulation; Vasodilator Agents | 2006 |
[COPE trial].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Japan; Male; Middle Aged; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Stroke | 2006 |
[Novel actions of calcium channel blockers].
Topics: Amlodipine; Animals; Azetidinecarboxylic Acid; Calcium Channel Blockers; Depression; Dihydropyridines; Evidence-Based Medicine; Heart Rate; Humans; Hypertension; Kidney Diseases; Proteinuria; Sympathetic Nervous System | 2006 |
Prognostic effects of calcium channel blockers in patients with vasospastic angina--a meta-analysis.
Topics: Amlodipine; Angina Pectoris; Asian People; Calcium Channel Blockers; Coronary Vasospasm; Dihydropyridines; Diltiazem; Humans; Nifedipine; Prognosis; Treatment Outcome | 2010 |
Renoprotective effects of the L-/T-type calcium channel blocker benidipine in patients with hypertension.
Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Hypertension; Kidney; Kidney Diseases | 2013 |
Vasospastic angina and Ca channel blockers.
Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Vasospasm; Dihydropyridines; Humans; Prognosis; Risk Factors | 2013 |
Physiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Disease Progression; Electrophysiological Phenomena; Humans; Immunologic Factors; Kidney; Kv1.3 Potassium Channel; Leukocytes; Macrolides; Membrane Potentials; Renal Insufficiency, Chronic; T-Lymphocytes | 2015 |
Roles of lymphocyte kv1.3-channels in the pathogenesis of renal diseases and novel therapeutic implications of targeting the channels.
Topics: Animals; Dihydropyridines; Humans; Kidney Diseases; Kv1.3 Potassium Channel; Lymphocyte Activation; Lymphocytes | 2015 |
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.
Topics: Amlodipine; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cattle; Dihydropyridines; Epithelial Cells; Humans; Hydrogen; Lipoproteins, LDL; Mice; Microsomes; Mitochondria; Niacinamide; Nifedipine; Nitrobenzenes; Oxidants; Oxidative Stress; Piperazines | 2016 |
Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis.
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Treatment Outcome; Vasodilator Agents | 2020 |
49 trial(s) available for benidipine and dihydropyridines
| Article | Year |
|---|---|
Benidipine counteracts sodium-induced alterations in systemic and regional hemodynamics.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Regional Blood Flow; Single-Blind Method; Sodium, Dietary | 1997 |
Absorption, metabolism and excretion after oral administration of a new Ca antagonist, 14C-benidipine hydrochloride to man.
Topics: Adult; Area Under Curve; Biological Availability; Blood Proteins; Calcium Channel Blockers; Chromatography, Gas; Chromatography, High Pressure Liquid; Dihydropyridines; Electrochemistry; Feces; Half-Life; Humans; Intestinal Absorption; Male; Protein Binding | 1997 |
Salt enhances responsiveness of terminal aortic vascular bed to sympathetic activity.
Topics: Aged; Aorta; Arginine Vasopressin; Calcium Channel Blockers; Diet, Sodium-Restricted; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Mesenteric Arteries; Norepinephrine; Prazosin; Renal Artery; Sodium Chloride, Dietary; Sympathetic Nervous System; Sympatholytics; Vascular Resistance | 1997 |
Effects of benidipine hydrochloride on 24-hour blood pressure and blood pressure response to mental stress in elderly patients with essential hypertension.
Topics: Administration, Oral; Aged; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Mental Processes; Middle Aged; Regression Analysis; Stress, Physiological | 1999 |
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine.
Topics: Apolipoproteins; Arteriosclerosis; Blood Glucose; Blood Platelets; Blood Pressure; Calcium; Calcium Channel Blockers; Catecholamines; Dihydropyridines; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin; Insulin Resistance; Intracellular Fluid; Male; Middle Aged; Treatment Outcome | 1999 |
Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Female; Humans; Hypertension; Indoles; Kidney Function Tests; Lipids; Male; Middle Aged; Nitrates; Nitrites | 2000 |
Effect of the calcium antagonist benidipine hydrochloride on 24-h ambulatory blood pressure in patients with mild to moderate hypertension in a double-blind study against placebo.
Topics: Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Pulse | 2000 |
Clinical trial of benidipine in mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Reference Values; Severity of Illness Index; Treatment Outcome | 1999 |
Effects of short- and long-acting calcium channel blockers on the relationship between blood pressure and physical activity.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Cross-Over Studies; Dihydropyridines; Exercise; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Systole | 2001 |
Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of stroke.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Chronotherapy; Circadian Rhythm; Cross-Over Studies; Dihydropyridines; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Nifedipine; Stroke | 2001 |
Effects of benidipine hydrochloride on autonomic nervous activity in hypertensive patients with high- and low-salt diets.
Topics: Aged; Autonomic Nervous System; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Diet, Sodium-Restricted; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Sodium, Dietary | 2003 |
Antihypertensive effects of long-acting calcium channel blockers on hemodialysis days--a randomized crossover trial between benidipine and nifedipine CR.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Dihydropyridines; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Renal Dialysis | 2004 |
Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects. Relationship between blood pressure and oxidative stress.
Topics: Aged; Antioxidants; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus; Dihydropyridines; Female; Humans; Hypertension; Male; Myocardial Ischemia; Oxidative Stress; Risk Factors; Thiobarbituric Acid Reactive Substances | 2004 |
Effects of calcium antagonists in hypertensive patients with renal dysfunction: a prospective, randomized, parallel trial comparing benidipine and nifedipine.
Topics: Calcium Channel Blockers; Dihydropyridines; Disease Progression; Female; Humans; Hypertension; Hypertension, Renovascular; Male; Middle Aged; Nifedipine; Prospective Studies | 2004 |
Assessing the bioequivalence of 4- and 8-mg benidipine tablets in healthy volunteers after a single oral dose.
Topics: Administration, Oral; Adult; Area Under Curve; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Generic; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Tablets; Therapeutic Equivalency | 2005 |
Benidipine, a long-acting calcium channel blocker, inhibits oxidative stress in polymorphonuclear cells in patients with essential hypertension.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Flow Cytometry; Humans; Hypertension; Male; Middle Aged; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Vasodilator Agents | 2005 |
Pharmacokinetics and pharmacodynamics of benidipine using a slow receptor-binding model.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Heart Rate; Humans; Models, Biological; Vasodilator Agents | 2005 |
Elevation of serum soluble E- and P-selectin in patients with hypertension is reversed by benidipine, a long-acting calcium channel blocker.
Topics: Blotting, Western; Calcium Channel Blockers; Case-Control Studies; Cell Adhesion Molecules; Dihydropyridines; E-Selectin; Female; Humans; Hypertension; Male; Middle Aged; P-Selectin | 2005 |
Long-term anti-hypertensive therapy with benidipine improves arterial stiffness over blood pressure lowering.
Topics: Adult; Antihypertensive Agents; Arteries; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Dihydropyridines; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nicardipine; Pulse; Regression Analysis | 2005 |
Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Diastole; Dihydropyridines; Drug Therapy, Combination; Female; Heparin; Humans; Hypertension; Lipid Metabolism; Lipids; Lipoprotein Lipase; Male; Systole; Tetrazoles | 2006 |
Renoprotective effect and cost-effectiveness of using benidipine, a calcium channel blocker, to lower the dose of angiotensin receptor blocker in hypertensive patients with albuminuria.
Topics: Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Cost-Benefit Analysis; Dihydropyridines; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Kidney; Male; Middle Aged | 2007 |
Benidipine attenuates glomerular hypertension and reduces albuminuria in patients with metabolic syndrome.
Topics: Albuminuria; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension, Renal; Kidney Glomerulus; Male; Metabolic Syndrome; Middle Aged; Renal Circulation; Treatment Outcome | 2007 |
Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study.
Topics: Aged; Amlodipine; Calcium Channel Blockers; Dihydropyridines; Female; Guideline Adherence; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Middle Aged; Proteinuria; Pulse; Renin-Angiotensin System | 2007 |
Electron paramagnetic resonance investigation on modulatory effect of benidipine on membrane fluidity of erythrocytes in essential hypertension.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Arginine; Blood Pressure; Blood Viscosity; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Female; Humans; Hypertension; Male; Membrane Fluidity; Middle Aged; Nitric Oxide; Treatment Outcome | 2008 |
Effects of azelnidipine on the autonomic functions and its influence on arterial stiffness and endothelial functions.
Topics: Aged; Arteries; Autonomic Pathways; Azetidinecarboxylic Acid; Brachial Artery; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Endothelium, Vascular; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pulse; Vasodilation | 2008 |
Efficacy and safety of benidipine therapy of essential hypertension in elderly Chinese patients.
Topics: Aged; Albuminuria; Antihypertensive Agents; Arteries; Blood Pressure; China; Dihydropyridines; Female; Humans; Hypertension; Male | 2008 |
Differential effects of calcium-channel blockers on vascular endothelial function in patients with coronary spastic angina.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Coronary Vasospasm; Dihydropyridines; Diltiazem; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Vasodilation; Verapamil | 2009 |
Comparison of the antiproteinuric effects of the calcium channel blockers benidipine and amlodipine administered in combination with angiotensin receptor blockers to hypertensive patients with stage 3-5 chronic kidney disease.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Protective Agents; Proteinuria | 2009 |
A comparative study of the renoprotective effects of benidipine and valsartan in primary hypertensive patients with proteinuria.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Proteinuria; Renal Circulation; Tetrazoles; Valine; Valsartan | 2009 |
Renoprotective effect of calcium channel blockers in combination with an angiotensin receptor blocker in elderly patients with hypertension. A randomized crossover trial between benidipine and amlodipine.
Topics: Aged; Aged, 80 and over; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Imidazoles; Male; Renal Insufficiency, Chronic; Tetrazoles | 2010 |
Comparative effects of benidipine and amlodipine on proteinuria, urinary 8-OHdG, urinary L-FABP, and inflammatory and atherosclerosis markers in early-stage chronic kidney disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Amlodipine; Atherosclerosis; Biomarkers; Calcium Channel Blockers; Deoxyguanosine; Dihydropyridines; Fatty Acid-Binding Proteins; Female; Humans; Inflammation; Kidney Failure, Chronic; Male; Proteinuria | 2010 |
Effects of treatment with once-daily nifedipine CR and twice-daily benidipine on prevention of symptomatic attacks in patients with coronary spastic angina pectoris-Adalat Trial vs Coniel in Tokyo against Coronary Spastic Angina (ATTACK CSA).
Topics: Acetylcholine; Angina Pectoris; Blood Pressure; Coronary Vasospasm; Dihydropyridines; Electrocardiography, Ambulatory; Ergonovine; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nitrates; Vasodilator Agents | 2010 |
[Renal protective effects of benidipine and valsartan in primary hypertension patients with proteinuria].
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Proteinuria; Tetrazoles; Valine; Valsartan | 2010 |
Comparison between the antiproteinuric effects of the calcium channel blockers benidipine and cilnidipine in combination with angiotensin receptor blockers in hypertensive patients with chronic kidney disease.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Creatinine; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Male; Proteinuria; Receptors, Angiotensin; Renal Insufficiency, Chronic | 2010 |
Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria.
Topics: Aged; Albuminuria; Aldosterone; Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Diabetic Nephropathies; Dihydropyridines; Female; Glomerular Filtration Rate; Glomerulonephritis; Humans; Hypertension; Male; Middle Aged; Nephrosclerosis; Potassium; Severity of Illness Index; Sodium | 2011 |
Antihypertensive efficacy and safety of benidipine and its effects on cardiac structure and function in elderly Chinese patients with mild to moderate hypertension: an open-label, long-term study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; China; Dihydropyridines; Echocardiography; Female; Heart; Heart Function Tests; Heart Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney Function Tests; Male; Middle Aged; Myocardium; Patient Compliance; Prospective Studies | 2011 |
Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Incidence; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Outcome Assessment, Health Care; Prospective Studies; Risk Factors; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Stroke; Treatment Outcome | 2011 |
Treatment of hypertension in patients 85 years of age or older: a J-BRAVE substudy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Prospective Studies | 2011 |
Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Incidence; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2012 |
Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Essential Hypertension; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Vascular Stiffness | 2013 |
Combination therapy for hypertension in patients with CKD: a subanalysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events trial.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2013 |
Comparison of the antialbuminuric effects of benidipine and hydrochlorothiazide in Renin-Angiotensin System (RAS) inhibitor-treated hypertensive patients with albuminuria: the COSMO-CKD (COmbination Strategy on Renal Function of Benidipine or Diuretics Tr
Topics: Adult; Aged; Albuminuria; Amlodipine; Blood Pressure; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic; Renin-Angiotensin System | 2014 |
Effects of the T/L-type calcium channel blocker benidipine on albuminuria and plasma aldosterone concentration. A pilot study involving switching from L-type calcium channel blockers to benidipine.
Topics: Aged; Albuminuria; Aldosterone; Blood Pressure; Calcium Channel Blockers; Creatinine; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Pilot Projects; Prospective Studies; Renin | 2014 |
Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Diuretics; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Prospective Studies; Risk Factors; Stroke; Thiazides | 2016 |
Improvements in Augmentation Index and Urinary Albumin Excretion With Benidipine in Hypertensive Patients With Chronic Kidney Disease.
Topics: Aged; Albuminuria; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hypertension; Male; Prospective Studies; Renal Insufficiency, Chronic | 2016 |
Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2017 |
Comparison of efficacy and safety between benidipine and hydrochlorothiazide in fosinopril-treated hypertensive patients with chronic kidney disease: protocol for a randomised controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; China; Dihydropyridines; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Fosinopril; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Kidney; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Proteinuria; Renal Insufficiency, Chronic; Research Design; Treatment Outcome; Young Adult | 2017 |
Effects of Calcium-Channel Blocker Benidipine-Based Combination Therapy on Cardiac Events - Subanalysis of the COPE Trial.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Thiazides; Treatment Outcome | 2018 |
Effect of rifampin on enantioselective disposition and anti-hypertensive effect of benidipine.
Topics: Adult; Antihypertensive Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Healthy Volunteers; Humans; Hypertension; Male; Rifampin; Stereoisomerism; Young Adult | 2019 |
161 other study(ies) available for benidipine and dihydropyridines
| Article | Year |
|---|---|
Protective effect of benidipine against the development of glomerular sclerosis in experimental nephrotic syndrome.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Glomerulosclerosis, Focal Segmental; Kidney; Male; Nephrotic Syndrome; Protamines; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley; Urine | 1992 |
Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats.
Topics: Animals; Arachidonic Acid; Benzoquinones; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Dihydropyridines; Evans Blue; Lipoxygenase Inhibitors; Male; Methacrylates; Nicardipine; Rats; Rats, Inbred Strains; Thromboxane-A Synthase; Ticlopidine | 1992 |
Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusion.
Topics: Acetylcholine; Animals; Blood Pressure; Calcium Channel Blockers; Celiac Artery; Constriction; Dihydropyridines; Endothelium, Vascular; Ischemia; Kinetics; Male; Mesenteric Arteries; Myocardial Depressant Factor; Rats; Rats, Inbred Strains; Shock; Vasodilation | 1991 |
Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Potentials; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium; Nerve Block; Nifedipine; Substance Withdrawal Syndrome | 1990 |
Calcium channel blockers reverse the sustained elevation of blood pressure induced by chronic infusion of endothelin in conscious rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelins; Hypertension; Male; Nifedipine; Peptides; Rats; Rats, Inbred Strains; Sodium | 1990 |
Chronic effects of synthetic endothelin on blood pressure and sodium excretion in rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Endothelins; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Sodium; Time Factors; Urine | 1990 |
Slow onset of and recovery from Ca blocking action of benidipine in rat aorta and portal vein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Portal Vein; Rats; Rats, Inbred Strains | 1989 |
Effects of antihypertensive drugs on renal function and atrial natriuretic polypeptide in spontaneously hypertensive rats with renal ablation.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Calcium Channel Blockers; Captopril; Dihydropyridines; Indapamide; Kidney; Male; Nephrectomy; Nifedipine; Rats; Rats, Inbred SHR; Reference Values | 1989 |
Inhibition of 3H-nitrendipine binding in rat aortic and cerebral cortex membranes by the new dihydropyridine calcium antagonist benidipine hydrochloride.
Topics: Animals; Aorta; Binding, Competitive; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; In Vitro Techniques; Male; Membranes; Microsomes; Myocardium; Nitrendipine; Rats; Rats, Inbred Strains; Stereoisomerism | 1989 |
Effect of benidipine on decreasing glomerular expansion in the experimental nephrotic syndrome.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Kidney Glomerulus; Male; Nephrotic Syndrome; Organ Size; Rats; Rats, Sprague-Dawley | 1995 |
Possible linkage between renal injury and cardiac remodeling in Dahl salt-sensitive rats treated with the calcium channel antagonist benidipine.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Hemodynamics; Hypertension, Renal; Kidney; Myocardium; Rats; Rats, Inbred Strains; Sodium, Dietary | 1995 |
Efficacy of benidipine hydrochloride on myocardial ischemia and reperfusion.
Topics: Animals; Calcium Channel Blockers; Creatine Kinase; Dihydropyridines; Heart Arrest, Induced; Heart Rate; Monitoring, Physiologic; Myocardial Ischemia; Myocardial Reperfusion Injury; Rabbits; Temperature; Ventricular Function; Ventricular Pressure | 1995 |
Effects of benidipine hydrochloride on contractions induced by some contractile agents in isolated cerebral and mesenteric arteries of dogs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Dogs; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Binding properties of (+/-)[3H]benidipine hydrochloride to rat heart membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Male; Membranes; Myocardium; Nitrendipine; Rats; Rats, Wistar | 1993 |
Cardiovascular effects of benidipine and amlodipine in isolated tissues and anesthetized dogs.
Topics: Amlodipine; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Dogs; Electric Stimulation; Female; Heart; In Vitro Techniques; Injections, Intravenous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Papillary Muscles | 1994 |
[The protective effect of benidipine hydrochloride against hypoxic myocardial injury of cultured mouse fetal heart cells].
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Cell Death; Cell Hypoxia; Cells, Cultured; Dihydropyridines; Fetal Heart; Heart; L-Lactate Dehydrogenase; Mice; Oxygen; Partial Pressure | 1995 |
Effects of benidipine on renal function in anesthetized spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Glomerular Filtration Rate; Hypertension; Kidney; Kidney Function Tests; Kidney Tubules; Lithium; Male; Rats; Rats, Inbred SHR; Renal Plasma Flow; Urodynamics | 1994 |
Mechanism of anti-obesity action of benidipine hydrochloride in mice.
Topics: Adipose Tissue, Brown; Analysis of Variance; Animals; Body Weight; Calcium Channel Blockers; Dihydropyridines; Eating; Female; Mice; Mice, Inbred ICR; Obesity | 1994 |
[Effect of calcium antagonist (benidipine) and alpha 1 blocker (urapidil) on renal hemodynamic responses to two acute environmental stresses in spontaneously hypertensive rats (SHR)].
Topics: Acute Disease; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Dihydropyridines; Female; Hypertension; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Stress, Physiological; Vascular Resistance | 1994 |
Anti-proliferative effects of benidipine hydrochloride in porcine cultured vascular smooth muscle cells and in rats subjected to balloon catheter-induced endothelial denudation.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Catheterization; Cell Division; Cells, Cultured; Dihydropyridines; DNA; Endothelium, Vascular; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Swine; Thymidine | 1994 |
Effects of benidipine hydrochloride (Coniel), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious, spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Heart Rate; Injections, Intravenous; Male; Microspheres; Rats; Rats, Inbred SHR; Regional Blood Flow; Vascular Resistance | 1994 |
Protective effects of benidipine against myocardial damage following ischemia and reperfusion in the isolated perfused rat heart.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Thromboxane A2; Vascular Resistance; Vasoconstrictor Agents | 1994 |
Inhibitory action of benidipine on balloon catheterization-induced intimal thickening of the carotid artery in rats.
Topics: Animals; Calcium Channel Blockers; Carotid Arteries; Catheterization; Cell Division; Dihydropyridines; DNA; Endothelium, Vascular; Histocytochemistry; Male; Rats; Rats, Sprague-Dawley | 1994 |
Radioautographic study of benidipine hydrochloride. Localization in the mesenteric artery of spontaneously hypertensive rat.
Topics: Animals; Autoradiography; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; In Vitro Techniques; Injections, Intravenous; Male; Mesenteric Arteries; Microscopy, Electron; Nitrendipine; Rats; Rats, Inbred SHR; Tissue Fixation | 1994 |
Effect of benidipine hydrochloride on regional blood flow of the adipose tissue in anesthetized rats.
Topics: Adipose Tissue; Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Heart Rate; Injections, Intravenous; Male; Rats; Rats, Wistar; Regional Blood Flow; Vascular Resistance | 1994 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Carotid Artery, Common; Dihydropyridines; Lactates; Lactic Acid; Male; Nicardipine; Nifedipine; Phosphocreatine; Potassium; Rats; Rats, Wistar; Sodium; Verapamil | 1993 |
Determination of benidipine hydrochloride in human plasma by capillary column gas chromatography-negative ion chemical ionization mass spectrometry.
Topics: Adult; Calcium Channel Blockers; Dihydropyridines; Gas Chromatography-Mass Spectrometry; Humans; Ions; Male; Reproducibility of Results; Sensitivity and Specificity | 1993 |
Benidipine improves endothelial function in renal resistance arteries of hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Heart Rate; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Time Factors; Todralazine; Vascular Resistance | 1996 |
Effects of benidipine, a calcium antagonist, on urinary kallikrein excretion and renal impairment in experimental diabetes.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Captopril; Diabetes Mellitus, Experimental; Dihydropyridines; Kallikreins; Male; Proteinuria; Radioimmunoassay; Rats; Rats, Inbred WKY; Streptozocin | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Effects of benidipine, a long-acting calcium antagonist, on renal functions in anaesthetized spontaneously hypertensive rats.
Topics: Amlodipine; Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Diuresis; Kidney; Kidney Function Tests; Lithium; Male; Natriuresis; Rats; Rats, Inbred SHR | 1995 |
Suppressive effects of benidipine on the development of hypertension and renal lesions in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hypertension; Kidney; Male; Organ Size; Rats; Rats, Inbred SHR | 1995 |
Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP).
Topics: Animals; Antioxidants; Blood Pressure; Calcium Channel Blockers; Catalase; Cerebrovascular Disorders; Creatine; Dihydropyridines; Drug Therapy, Combination; Glutathione Peroxidase; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Male; Organ Size; Oxidoreductases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; Superoxide Dismutase | 1997 |
Effect of benidipine on microvascular remodeling and coronary flow reserve in two-kidney, one clip Goldblatt hypertension.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Male; Microcirculation; Rats; Rats, Sprague-Dawley | 1997 |
Relationship between plasma concentration and antihypertensive effect of the dihydropyridine calcium antagonist, benidipine, in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Calcium Channel Blockers; Dihydropyridines; Half-Life; Hypertension; Injections, Intravenous; Male; Molecular Structure; Rats; Rats, Inbred SHR; Rats, Wistar; Species Specificity; Splanchnic Circulation | 1997 |
How a dihydropyridine calcium channel blocker, benidipine, acts on ambulatory blood pressure influenced by daily physical activity.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Humans; Middle Aged; Physical Exertion | 1997 |
Absorption, distribution, metabolism and excretion of 14C-labelled enantiomers of the calcium channel blocker benidipine after oral administration to rat.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dihydropyridines; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism | 1998 |
Effect of benidipine hydrochloride, a dihydropyridine-type calcium antagonist, on the function of mouse osteoblastic cells.
Topics: Alkaline Phosphatase; Animals; Calcitriol; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Mice; Osteoblasts | 1998 |
A Ca channel blocker, benidipine, increases coronary blood flow and attenuates the severity of myocardial ischemia via NO-dependent mechanisms in dogs.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Energy Metabolism; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Vasodilation | 1999 |
A calcium antagonist protects against doxorubicin-induced impairment of calcium handling in neonatal rat cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Signaling; Cardiomyopathies; Cells, Cultured; Dihydropyridines; Doxorubicin; Heart; Ion Transport; Isoproterenol; Myocardial Contraction; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta | 1999 |
Benidipine induces thermogenesis in brown adipose tissue by releasing endogenous noradrenaline: a possible mechanism for the anti-obesity effect of calcium antagonists.
Topics: Adipose Tissue, Brown; Adrenergic beta-Antagonists; Animals; Body Temperature Regulation; Calcium Channel Blockers; Cricetinae; Dihydropyridines; Male; Mice; Norepinephrine; Obesity; Propranolol; Rats; Rats, Sprague-Dawley | 1999 |
Arteriolar and venular vasodilating properties of benidipine hydrochloride, a 1,4-dihydropyridine Ca2+ antagonist with long-lasting action, assessed in rat mesenteric microcirculation.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Arterioles; Blood Flow Velocity; Blood Vessels; Calcium Channel Blockers; Dihydropyridines; Male; Mesentery; Microcirculation; Platelet Aggregation; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents; Venules | 1999 |
Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Dihydropyridines; DNA Primers; Heart Ventricles; Hypertension, Renovascular; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Effects of a novel calcium antagonist, benidipine hydrochloride, on platelet responsiveness to mental stress in patients with essential hypertension.
Topics: Adult; Aged; beta-Thromboglobulin; Blood Platelets; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stress, Psychological | 1999 |
Vasodilating effect of benidipine hydrochloride in the renal and hindquarter vascular regions (supplied by terminal aorta) of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Heart Rate; Hindlimb; Injections, Intravenous; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Wistar; Regional Blood Flow; Renal Circulation; Vascular Resistance; Vasodilator Agents | 1999 |
[Effects of benidipine hydrochloride (Coniel) on blood pressure, heart rate and plasma norepinephrine concentration in spontaneously hypertensive rats].
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart Rate; Hypertension; Male; Nifedipine; Norepinephrine; Rats; Rats, Inbred SHR | 1999 |
Effect of benidipine on depolarizing stimulation-induced increase of intracellular calcium concentration in cultured mouse hippocampal neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electric Stimulation; Hippocampus; Mice; Neurons; Nicardipine; Nifedipine | 1999 |
Is there any difference between intermediate-acting and long-acting calcium antagonists in diurnal blood pressure and autonomic nervous activity in hypertensive coronary artery disease patients?
Topics: Autonomic Nervous System; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Coronary Disease; Delayed-Action Preparations; Dihydropyridines; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Treatment Outcome | 2000 |
Effect of calcium channel blockers, nifedipine and benidipine, on death of cultured mouse mesangi al cells.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cycloheximide; Dihydropyridines; Glomerular Mesangium; L-Lactate Dehydrogenase; Mice; Nifedipine; Protein Synthesis Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
Benidipine inhibits apoptosis during ischaemic acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Blood Urea Nitrogen; Calcium Channel Blockers; Creatinine; Dihydropyridines; In Situ Nick-End Labeling; Ischemia; Kidney Cortex; Kidney Tubules; Male; Rats; Rats, Wistar | 2000 |
New approach for measurement of sympathetic nervous abnormality in conscious, spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Heart Rate; Hypertension; Male; Norepinephrine; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System | 2000 |
Protective effect of benidipine against the abnormal electrical activity in single ventricular myocytes of the guinea pig under simulated ischemic conditions and reperfusion.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury | 2000 |
Possible involvement of endothelin-1 in cardioprotective effects of benidipine.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cardiomegaly; Cells, Cultured; Dihydropyridines; Endothelin-1; Hypertension; Leucine; Muscle Fibers, Skeletal; Myocardium; Nifedipine; Rats; Rats, Wistar; Thymidine; Tritium | 2000 |
Effects of vasodilatory antihypertensive agents on endothelial dysfunction in rats with ischemic acute renal failure.
Topics: Acetylcholine; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Body Weight; Calcium Channel Blockers; Celiprolol; Creatinine; Desoxycorticosterone; Dihydropyridines; Endothelium, Vascular; Imidazoles; Imidazolidines; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2000 |
Effects of benidipine hydrochloride on cerebrovascular lesions in salt-loaded stroke-prone spontaneously hypertensive rats: evaluation by magnetic resonance imaging.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Brain; Cerebrovascular Disorders; Dihydropyridines; Disease Models, Animal; Magnetic Resonance Imaging; Male; Psychomotor Performance; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Vasodilator Agents | 2000 |
Benidipine, a long-acting calcium-channel blocker, prevents the progression to end-stage renal failure in a rat mesangioproliferative glomerulonephritis.
Topics: Actins; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Creatinine; Dihydropyridines; Disease Models, Animal; Disease Progression; Fluorescent Antibody Technique; Glomerulonephritis, Membranoproliferative; Hydralazine; Kidney Failure, Chronic; Kidney Glomerulus; Male; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Transforming Growth Factor beta; Vasodilator Agents | 2000 |
Anti-apoptotic effect of benidipine, a long-lasting vasodilating calcium antagonist, in ischaemic/reperfused myocardial cells.
Topics: Animals; Apoptosis; Blood Pressure; Calcium; Calcium Channel Blockers; Dihydropyridines; Heart Rate; In Situ Nick-End Labeling; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rabbits; Vasodilator Agents; Ventricular Function, Left | 2001 |
A calcium channel blocker, benidipine, inhibits intimal thickening in the carotid artery of mice by increasing nitric oxide production.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Carotid Artery, Common; Cell Division; Dihydropyridines; Endothelium, Vascular; Growth Inhibitors; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 2001 |
Effects of calcium antagonist, benidipine, on the progression of chronic renal failure in the elderly: a 1-year follow-up.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Creatine; Dihydropyridines; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Retrospective Studies; Treatment Outcome | 2001 |
Benidipine inhibits expression of ET-1 and TGF-beta1 in Dahl salt-sensitive hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Calcium Channel Blockers; Dihydropyridines; Endothelin-1; Endothelins; Gene Expression; Heart Ventricles; Hypertension; Male; Myocardium; Organ Size; Protein Precursors; Rats; Rats, Inbred Dahl; Receptor, Endothelin A; Receptors, Endothelin; RNA, Messenger; Sodium Chloride, Dietary; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2001 |
Benidipine dilates both pre- and post-glomerular arteriole in the canine kidney.
Topics: Animals; Arterioles; Capillary Permeability; Dihydropyridines; Dogs; Glomerular Filtration Rate; Homeostasis; Kidney; Kidney Glomerulus; Renal Circulation; Vascular Resistance; Vasodilation; Vasodilator Agents | 2001 |
Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-dependent mechanisms in canine hearts.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Calcium Channel Blockers; Dihydropyridines; Dogs; Enzyme Inhibitors; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxidase | 2001 |
A potent 1,4-dihydropyridine L-type calcium channel blocker, benidipine, promotes osteoblast differentiation.
Topics: Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Cell Line; Cytosol; Dihydropyridines; DNA; DNA Primers; Dose-Response Relationship, Drug; Extracellular Matrix; Mice; Osteoblasts; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats.
Topics: Acetylcholine; Amides; Animals; Basilar Artery; Body Weight; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Male; Muscle Relaxants, Central; Nitric Oxide Donors; Nitroprusside; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasodilation; Vasodilator Agents | 2002 |
Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodelling in a Type II diabetic rat model.
Topics: Animals; Calcium Channel Blockers; Capillaries; Collagen; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dihydropyridines; Disease Models, Animal; Endothelial Growth Factors; Fibroblast Growth Factor 2; Gene Expression Regulation; Lymphokines; Male; Neovascularization, Pathologic; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred Strains; RNA, Messenger; Species Specificity; Transcription, Genetic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Long-term effects of benidipine hydrochloride on severe left ventricular hypertrophy and collagen metabolism in patients with essential hypertension.
Topics: Administration, Oral; Aged; Calcium Channel Blockers; Collagen; Dihydropyridines; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinase 1; Middle Aged; Tissue Inhibitor of Metalloproteinase-1 | 2002 |
Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker.
Topics: Albuminuria; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Genetic Predisposition to Disease; Hypertension; Kidney Glomerulus; Male; Phosphorylation; Proteinuria; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Platelet-Derived Growth Factor beta; Stroke; Tyrosine | 2002 |
Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Calcium Channel Blockers; Cilazapril; Dihydropyridines; Drug Therapy, Combination; Heart Failure; Hypertension; Kidney; Natriuretic Peptide, Brain; Organ Size; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Survival Rate; Systole; Transforming Growth Factor beta | 2002 |
In vivo receptor binding of benidipine and amlodipine in mesenteric arteries and other tissues of spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Area Under Curve; Blood Proteins; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Drug Interactions; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Protein Binding; Rats; Rats, Inbred SHR; Tissue Distribution | 2002 |
Effects of benidipine on glomerular hemodynamics and proteinuria in patients with nondiabetic nephropathy.
Topics: Aged; Arterioles; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Kidney Diseases; Kidney Glomerulus; Male; Middle Aged; Natriuresis; Proteinuria; Vascular Resistance | 2002 |
Protective effects of benidipine on hydrogen peroxide-induced injury in rat isolated hearts.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Dihydropyridines; Heart; Hydrogen Peroxide; Male; Myocardium; Organ Culture Techniques; Oxidants; Rats; Rats, Wistar | 2003 |
Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats.
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Enzyme Inhibitors; Heart Rate; Heart Ventricles; Kinetics; Male; Mitogen-Activated Protein Kinases; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Ribosomal Protein S6 Kinases, 70-kDa | 2003 |
Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase.
Topics: Acute Disease; Animals; Autoimmune Diseases; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heart Rate; Myocarditis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Tyrosine | 2003 |
Hyperkalemia induced by the calcium channel blocker, benidipine.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hyperkalemia; Hypertension; Risk Assessment; Severity of Illness Index | 2003 |
Effects of benidipine and candesartan on kidney and vascular function in hypertensive Dahl rats.
Topics: Albuminuria; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Hypertension; Kidney; Male; Mesenteric Artery, Superior; Rats; Rats, Inbred Dahl; Tetrazoles; Vasodilation; Vasodilator Agents | 2003 |
Renoprotective effects of benidipine in combination with angiotensin II type 1 receptor blocker in hypertensive Dahl rats.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Calcium Channel Blockers; Creatinine; Dihydropyridines; Drug Therapy, Combination; Hypertension, Renal; Kidney; Male; Rats; Rats, Inbred Dahl; Tetrazoles | 2003 |
Protective effect of benidipine against sodium azide-induced cell death in cultured neonatal rat cardiac myocytes.
Topics: Adenosine Triphosphate; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Captopril; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dihydropyridines; Dipeptides; Dose-Response Relationship, Drug; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria, Muscle; Myocytes, Cardiac; Nifedipine; Rats; Rats, Sprague-Dawley; Sodium Azide; Tetrazoles | 2003 |
Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Creatine Kinase; Dihydropyridines; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrobenzenes; Piperazines; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Function, Left | 2004 |
Determination of benidipine in human plasma using liquid chromatography-tandem mass spectrometry.
Topics: Area Under Curve; Calcium Channel Blockers; Chromatography, Liquid; Dihydropyridines; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2004 |
Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits.
Topics: Animals; Dihydropyridines; Hemodynamics; Hydroxyl Radical; Male; Myocardial Infarction; Nitric Oxide; Protein Kinase C; Rabbits | 2004 |
Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Coronary Vessels; Cytochromes c; Dihydropyridines; Flavonoids; Male; Mitochondria; Mitogen-Activated Protein Kinase 3; Myocardial Ischemia; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2004 |
Combined effects of benidipine and diltiazem in a rat model of experimental angina.
Topics: Angina Pectoris; Animals; Arginine Vasopressin; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Male; Rats; Rats, Inbred Strains; Time Factors; Vasoconstrictor Agents | 2004 |
Effects of benidipine, a dihydropyridine-Ca2+ channel blocker, on expression of cytokine-induced adhesion molecules and chemoattractants in human aortic endothelial cells.
Topics: Antioxidants; Aorta; Calcium Channel Blockers; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Chemokine CCL2; Chemotactic Factors; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereoisomerism; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2004 |
Changing characteristics of patients with vasospastic angina in the era of new calcium channel blockers.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Amlodipine; Angina Pectoris, Variant; Calcium Channel Blockers; Cohort Studies; Diabetes Complications; Dihydropyridines; Female; Humans; Hyperlipidemias; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Prognosis; Smoking; Survival Rate; Vasodilator Agents | 2004 |
Benidipine, a dihydropyridine-calcium channel blocker, prevents lysophosphatidylcholine-induced injury and reactive oxygen species production in human aortic endothelial cells.
Topics: Antioxidants; Aorta; Calcium Channel Blockers; Caspase 3; Caspase 7; Caspases; Cells, Cultured; Dihydropyridines; Endothelial Cells; Enzyme Activation; Humans; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species | 2005 |
A calcium channel blocker, benidipine, improves cell membrane fluidity in human subjects via a nitric oxide-dependent mechanism. An electron paramagnetic resonance investigation.
Topics: Aged; Arginine; Calcium Channel Blockers; Cell Membrane; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocytes; Female; Hemorheology; Humans; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Viscosity | 2004 |
Analysis of benidipine enantiomers in human plasma by liquid chromatography-mass spectrometry using a macrocyclic antibiotic (Vancomycin) chiral stationary phase column.
Topics: Calcium Channel Blockers; Chromatography, Liquid; Dihydropyridines; Humans; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2005 |
[Effect of benidipine on plasma level of calcitonin gene-related peptide in essential hypertension].
Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged | 2004 |
Benidipine, a long-acting calcium channel blocker, inhibits cardiac remodeling in pressure-overloaded mice.
Topics: Animals; Biomarkers; Calcium Channel Blockers; Cardiomegaly; Cells, Cultured; Collagen Type IV; Dihydropyridines; Disease Progression; Gene Expression Regulation; Heart Failure; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Myocytes, Cardiac; Natriuretic Peptide, Brain; Nitric Oxide; Signal Transduction; Ventricular Remodeling | 2005 |
Benidipine improves oxidized LDL-dependent monocyte and endothelial dysfunction in hypertensive patients with type 2 diabetes mellitus.
Topics: Aged; Autoantibodies; Biomarkers; Diabetes Mellitus, Type 2; Dihydropyridines; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Monocytes; Oxidation-Reduction; Retrospective Studies; Time Factors; Vasodilator Agents | 2005 |
The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model.
Topics: Age Factors; Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Dihydropyridines; Disease Models, Animal; Down-Regulation; Endothelin-1; Insulin Resistance; Male; Myocardium; Rats; Rats, Inbred OLETF; Rats, Long-Evans | 2004 |
A calcium-channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension.
Topics: Aged; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Forearm; Hepatocyte Growth Factor; Humans; Hyperemia; Hypertension; Middle Aged; Nitroglycerin; Time Factors; Vasodilator Agents | 2005 |
Benidipine, a dihydropyridine-calcium channel blocker, inhibits lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release.
Topics: Apoptosis; Calcium Channel Blockers; Cell Line; Cytoprotection; Dihydropyridines; Endothelial Cells; Endothelium, Vascular; Humans; Lysophosphatidylcholines; Nitric Oxide; Nitric Oxide Synthase Type III; Umbilical Veins | 2006 |
Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats.
Topics: Animals; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Male; Rats; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Remodeling | 2006 |
Benidipine, a calcium channel blocker, regulates proliferation and phenotype of vascular smooth muscle cells.
Topics: Animals; Aorta, Abdominal; Biomarkers; Blotting, Western; Calcium Channel Blockers; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Phenotype; Polymerase Chain Reaction; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa | 2006 |
Combined effects of benidipine and diltiazem on cardiohemodynamics in anesthetized dogs.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Calibration; Coronary Circulation; Dihydropyridines; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Heart; Hemodynamics; Injections, Intravenous | 2006 |
Reversal of elevated cardiac expression of TGFbeta1 and endothelin-1 in OLETF diabetic rats by long-acting calcium antagonist.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Hydrazines; Insulin; Male; Random Allocation; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Transforming Growth Factor beta | 2006 |
Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats.
Topics: Animals; Biopterins; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Kidney; Male; Nitric Oxide; Proteinuria; Rats; Rats, Inbred OLETF; Rats, Long-Evans | 2006 |
Effects of combination of angiotensin receptor blocker and calcium channel blocker on ox-LDL levels and cardiovascular dysfunction in Dahl rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Heart; Hypotension; Lipoproteins, LDL; Male; Muscle, Smooth, Vascular; Organ Size; Phenylephrine; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Tetrazoles; Time Factors; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Effects of benidipine, a long-lasting dihydropyridine-Ca2+ channel blocker, on cerebral blood flow autoregulation in spontaneously hypertensive rats.
Topics: Administration, Oral; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Carbon Dioxide; Cerebral Cortex; Dihydropyridines; Hypertension; Male; Oxygen; Rats; Rats, Inbred SHR; Rats, Wistar; Species Specificity; Tetrazoles; Ultrasonography, Doppler, Pulsed; Vascular Resistance | 2006 |
Effects of benidipine in a rat model for experimental angina.
Topics: Amlodipine; Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred Strains | 2006 |
Comparison of the antiatherosclerotic effects of dihydropyridine calcium channel blocker and HMG-CoA reductase inhibitor on hypercholesterolemic rabbits.
Topics: Animals; Aorta, Thoracic; Atherosclerosis; Calcium Channel Blockers; Cholesterol; Dihydropyridines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperplasia; Male; Pravastatin; Rabbits; RNA, Messenger; Scavenger Receptors, Class E; Time Factors; Tunica Intima; Up-Regulation; Vascular Cell Adhesion Molecule-1; Vasodilation | 2007 |
Clinical efficacy of benidipine for vasospastic angina pectoris.
Topics: Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Coronary Vasospasm; Cyclic GMP; Dihydropyridines; Diltiazem; Female; Heart Rate; Humans; Male; Middle Aged; Nitric Oxide; Treatment Failure; Treatment Outcome; Vasodilator Agents | 2007 |
Benidipine, a dihydropyridine-Ca2+ channel blocker, increases the endothelial differentiation of endothelial progenitor cells in vitro.
Topics: Animals; Calcium Channel Blockers; Cell Differentiation; Dihydropyridines; Endothelial Cells; Endothelium, Vascular; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protective Agents; Proto-Oncogene Proteins c-akt; Stem Cells | 2006 |
A case of vasospastic angina showing resolution of coronary vasospasm in acetylcholine provocation test corresponding to regression of coronary atherosclerosis.
Topics: Acetylcholine; Angina Pectoris; Angina Pectoris, Variant; Anticholesteremic Agents; Cholinergic Agents; Coronary Artery Disease; Coronary Vasospasm; Dihydropyridines; Humans; Hypercholesterolemia; Male; Middle Aged; Pravastatin; Ultrasonography; Vasodilator Agents | 2008 |
Effects of compression on the interaction between 1,4-dihydropyridine compounds and lactose monohydrate (II): differences in powder properties of 1,4-dihydropyridine compounds.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Dihydropyridines; Lactose; Nitrobenzenes; Particle Size; Piperazines; Powders; Pressure; Tablets; Temperature | 2007 |
Characterization of benidipine and its enantiomers' metabolism by human liver cytochrome P450 enzymes.
Topics: Biotransformation; Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Dihydropyridines; DNA, Complementary; Humans; Isoenzymes; Liver; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Proadifen; Stereoisomerism | 2007 |
Effect of benidipine on simvastatin metabolism in human liver microsomes.
Topics: Algorithms; Area Under Curve; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Microsomes, Liver; Models, Biological; Molecular Structure; Simvastatin | 2007 |
Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, benidipine hydrochloride in rats.
Topics: Adipose Tissue, Brown; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Gene Expression; Hydrochloric Acid; Hypertension; Ion Channels; Male; Mitochondrial Proteins; Muscle, Skeletal; Rats; Rats, Inbred SHR; Rats, Wistar; Thermogenesis; Uncoupling Protein 1; Uncoupling Protein 3; Up-Regulation | 2007 |
Effect of benidipine hydrochloride, a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Analysis after switching from cilnidipine to benidipine.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Diabetes Complications; Dihydropyridines; Female; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Proteinuria; Retrospective Studies | 2007 |
Effects of benidipine and some other calcium channel blockers on the prognosis of patients with vasospastic angina. Cohort study with evaluation of the ergonovine coronary spasm induction test.
Topics: Adult; Aged; Aging; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cohort Studies; Coronary Angiography; Coronary Stenosis; Coronary Vasospasm; Diabetes Complications; Dihydropyridines; Diltiazem; Ergonovine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Oxytocics; Prognosis; Risk Factors | 2007 |
Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Hypertension; Male; NADP; Neutrophils; Oxidative Stress; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Sodium Chloride, Dietary; Stroke | 2008 |
Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts.
Topics: Animals; Atrial Natriuretic Factor; Cardiotonic Agents; Collagen Type I; Dihydropyridines; Gene Expression; Heart Failure; Hypertension, Renal; Intercellular Adhesion Molecule-1; Myosin Heavy Chains; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Inbred Dahl; Scavenger Receptors, Class E; Superoxide Dismutase; Superoxide Dismutase-1; Transcription Factor RelA; Transforming Growth Factor beta1; Vascular Cell Adhesion Molecule-1; Vasodilator Agents; Ventricular Function; Ventricular Remodeling | 2008 |
Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line; Cytochrome P-450 CYP11B2; Dihydropyridines; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Membrane Potentials; Patch-Clamp Techniques; Potassium Chloride; RNA, Messenger; Steroid 11-beta-Hydroxylase; Tetrazoles; Valine; Valsartan | 2008 |
Prognostic effects of benidipine in patients with vasospastic angina: comparison with diltiazem and amlodipine.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Diseases; Cohort Studies; Coronary Vasospasm; Dihydropyridines; Diltiazem; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Risk Factors | 2008 |
Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Fibrosis; Heart; In Vitro Techniques; Losartan; Metabolic Syndrome; Muscle Relaxation; Myocardium; Nitrates; Nitrites; Rats; Rats, Inbred OLETF; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Treatment of coronary spastic angina with a statin in addition to a calcium channel blocker: a pilot study.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Cholesterol, HDL; Cholesterol, LDL; Coronary Vasospasm; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipoproteins, LDL; Male; Malondialdehyde; Middle Aged; Pilot Projects; Pravastatin | 2008 |
The effects of calcium channel blocker benidipine and calmodulin antagonist W7 on GDP-binding capacity of brown adipose tissue in mice.
Topics: Adipose Tissue, Brown; Animals; Calcium Channel Blockers; Calmodulin; Dihydropyridines; Enzyme Inhibitors; Female; Guanosine Diphosphate; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Sulfonamides; Thermogenesis | 2009 |
Prognostic effects of calcium channel blockers on cardiac events, stroke and end-stage renal disease in patients with angina pectoris. Retrospective comparative study of benidipine, diltiazem and nifedipine.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Heart Diseases; Humans; Kidney Failure, Chronic; Male; Nifedipine; Prognosis; Proportional Hazards Models; Retrospective Studies; Stroke; Treatment Outcome | 2008 |
The dihydropyridine calcium channel blocker benidipine prevents lysophosphatidylcholine-induced endothelial dysfunction in rat aorta.
Topics: Administration, Oral; Animals; Antioxidants; Aorta; Calcium; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Endothelial Cells; Endothelium, Vascular; Fluorescence Recovery After Photobleaching; Lysophosphatidylcholines; Male; Rats; Rats, Sprague-Dawley | 2009 |
Effects of benidipine, a long-acting T-type calcium channel blocker, on home blood pressure and renal function in patients with essential hypertension: a retrospective, 'real-world' comparison with amlodipine.
Topics: Adult; Aged; Albuminuria; Amlodipine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Retrospective Studies | 2009 |
Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome.
Topics: AMP-Activated Protein Kinases; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Channel Blockers; Carnitine O-Palmitoyltransferase; Cholesterol; Dihydropyridines; Disease Models, Animal; Kidney; Lipid Metabolism; Losartan; Male; Metabolic Syndrome; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Superoxides; Triglycerides | 2010 |
Benidipine, a dihydropyridine L-type/T-type calcium channel blocker, affords additive benefits for prevention of cardiorenal injury in hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Enzyme-Linked Immunosorbent Assay; Heart; Heart Rate; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2010 |
The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Topics: Aldosterone; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, T-Type; Cell Line; Dihydropyridines; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Models, Molecular; Molecular Conformation; Mutation; Pyridines; Receptors, Mineralocorticoid; Spironolactone; Stereoisomerism | 2010 |
Effects of combination therapy with angiotensin II type I receptor blockers and calcium channel blockers on renal function in hypertensive patients/a retrospective, "real-world" comparative study.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Creatinine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hypertension; Kaplan-Meier Estimate; Kidney; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Nifedipine; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Treatment Outcome | 2010 |
[Antihypertrophic effect of dihydropyridines calcium channel blockers is dependent on their potential of blocking N-type calcium channel].
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cardiomegaly; Dihydropyridines; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nifedipine | 2010 |
Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Coronary Circulation; Diastole; Dihydropyridines; Heart Failure; Heart Ventricles; Hypertension; Male; Neovascularization, Physiologic; Nitrendipine; Rats; Rats, Inbred Dahl | 2010 |
Benidipine hydrochloride intoxication in a child.
Topics: Calcium Channel Blockers; Charcoal; Dihydropyridines; Female; Glucose; Humans; Infant; Lactulose; Treatment Outcome | 2012 |
Effects of eplerenone on nephrotic syndrome in a patient with renovascular hypertension.
Topics: Amlodipine; Antihypertensive Agents; Dihydropyridines; Eplerenone; Humans; Hypertension, Renovascular; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Nephrotic Syndrome; Proteinuria; Radiography; Spironolactone; Treatment Outcome | 2011 |
Effect of antihypertensive treatment on cardiovascular events in elderly hypertensive patients: Japan's Benidipine Research on Antihypertensive Effects in the Elderly (J-BRAVE).
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Prospective Studies; Risk Factors | 2011 |
Mechanism underlying the block of human Cav3.2 T-type Ca2+ channels by benidipine, a dihydropyridine Ca2+ channel blocker.
Topics: Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; HEK293 Cells; Humans; Ion Channel Gating | 2011 |
Is there an optimal combination of antihypertensives for preventing cardiovascular events?
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Male; Sodium Chloride Symporter Inhibitors; Stroke | 2011 |
Cutaneous pseudolymphoma due to benidipine hydrochloride with massive infiltration of eosinophils.
Topics: Aged; Aged, 80 and over; Dihydropyridines; Drug Eruptions; Eosinophils; Female; Humans; Pseudolymphoma | 2011 |
Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice.
Topics: Aldosterone; Animals; Apoptosis; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Down-Regulation; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Oxidative Stress; Ventricular Dysfunction, Left | 2012 |
[Shortening of donepezil-induced QTc prolongation with a change in the interacting drug, after electrocardiograph monitoring by community pharmacists: a case report].
Topics: Aged, 80 and over; Amlodipine; Cholinesterase Inhibitors; Community Pharmacy Services; Dihydropyridines; Donepezil; Drug Interactions; Electrocardiography, Ambulatory; Female; Humans; Indans; Pharmacists; Piperidines; Risk; Risk Management; Torsades de Pointes | 2012 |
Voltammetric and RP-LC assay for determination of benidipine HCl.
Topics: Calcium Channel Blockers; Chromatography, Liquid; Dihydropyridines; Electrochemical Techniques; Electrodes; Hydrolysis; Oxidation-Reduction; Sensitivity and Specificity; Tablets; Temperature | 2012 |
Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Kv1.3 Potassium Channel; Male; Membrane Potentials; Mice; Nifedipine; Thymocytes | 2013 |
Effects of a benidipine-based combination therapy on the risk of stroke according to stroke subtype: the COPE trial.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; Blood Pressure; Brain Ischemia; Dihydropyridines; Diuretics; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Rate; Humans; Hypertension; Intracranial Hemorrhages; Kaplan-Meier Estimate; Male; Middle Aged; Risk Factors; Stroke; Survival Analysis; Vasodilator Agents | 2013 |
Benidipine protects kidney through inhibiting ROCK1 activity and reducing the epithelium-mesenchymal transdifferentiation in type 1 diabetic rats.
Topics: Animals; Calcium Channel Blockers; Cell Transdifferentiation; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dihydropyridines; Epithelial-Mesenchymal Transition; Fibrosis; Kidney; Male; Rats; Rats, Wistar; rho-Associated Kinases | 2013 |
Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Cytoprotection; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation Mediators; Isoproterenol; Lipid Peroxidation; Male; Myocardial Infarction; Myocardium; Myofibrils; Oxidative Stress; Rats, Wistar; Time Factors | 2015 |
Benidipine suppresses in situ proliferation of leukocytes and slows the progression of renal fibrosis in rat kidneys with advanced chronic renal failure.
Topics: Animals; Blood Urea Nitrogen; Calcium Channel Blockers; Cell Proliferation; Creatinine; Cytokines; Dihydropyridines; Disease Models, Animal; Disease Progression; Fibrosis; Kidney; Kidney Failure, Chronic; Kv1.3 Potassium Channel; Leukocytes; Male; Nephrectomy; Rats; Rats, Sprague-Dawley | 2014 |
Computer-guided drug repurposing: identification of trypanocidal activity of clofazimine, benidipine and saquinavir.
Topics: Animals; Clofazimine; Cysteine Endopeptidases; Dihydropyridines; Drug Repositioning; Female; Male; Mice; Molecular Docking Simulation; Protein Conformation; Protozoan Proteins; Saquinavir; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells.
Topics: Animals; Calcium Channel Blockers; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Dihydropyridines; Female; Femur; Mesenchymal Stem Cells; Mice, Inbred C57BL; Osteoblasts; Osteocalcin; Osteogenesis; Vasodilator Agents; Wnt Signaling Pathway | 2015 |
Effect of Benidipine in Human Internal Mammary Artery and Clinical Implications.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Mammary Arteries; Myography; Potassium Chloride; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2016 |
Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage.
Topics: Animals; Antipyrine; Apoptosis; C-Reactive Protein; Calcium Channel Blockers; Caspase 3; Dihydropyridines; Edaravone; Female; Free Radical Scavengers; Isoproterenol; Male; Malondialdehyde; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Rats, Wistar | 2016 |
A case of initial rhythm of pulseless electrical activity caused by vasospastic angina.
Topics: Angiocardiography; Cardiopulmonary Resuscitation; Coronary Angiography; Coronary Vasospasm; Dihydropyridines; Electrophysiologic Techniques, Cardiac; Heart Arrest; Humans; Isosorbide Dinitrate; Male; Middle Aged; Treatment Outcome; Vasodilator Agents | 2016 |
Prevention of infertility induced by ovarian ischemia reperfusion injury by benidipine in rats: Biochemical, gene expression, histopathological and immunohistochemical evaluation.
Topics: Animals; Apoptosis; Dihydropyridines; Female; Gene Expression; Glutathione; Infertility, Female; Interleukin-1beta; Malondialdehyde; Models, Animal; Ovary; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2017 |
Life-Threatening Ventricular Arrhythmia Following Exercise-Induced Vasospastic Myocardial Ischemia at the Site of a Myocardial Bridge With Progressive J-Wave Manifestation.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Dihydropyridines; Electrocardiography; Exercise Test; Humans; Magnetic Resonance Imaging; Male; Myocardial Ischemia; Treatment Outcome; Ventricular Dysfunction | 2018 |
Moderate hypothermia and responses to calcium channel blockers - Role of the nitric oxide.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cold Temperature; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypothermia, Induced; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase Type III; Vasodilation; Vasodilator Agents; Verapamil | 2018 |
Benidipine, an anti-hypertensive drug, relaxes mouse airway smooth muscle.
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Respiratory System | 2019 |
Dissociation of coronary computed tomography and stress myocardial scintigraphy: a case of vasospasm.
Topics: Angina Pectoris; Computed Tomography Angiography; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; Dihydropyridines; Exercise Test; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Physical Exertion; Predictive Value of Tests; Vasoconstriction; Vasodilator Agents | 2019 |
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Chronic Disease; Clofazimine; Combined Modality Therapy; Dihydropyridines; Female; Humans; Mice; Mice, Inbred C3H; Nitroimidazoles; Trypanocidal Agents; Vero Cells | 2019 |
Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-analysis of the COPE Trial
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Humans; Hypertension; Japan; Outpatients | 2020 |
Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells.
Topics: Animals; Antihypertensive Agents; Apoptosis; Calcium Channel Blockers; Calcium Channels; Carcinoma, Ovarian Epithelial; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dihydropyridines; Drug Repositioning; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Neoplastic Stem Cells; Nitrobenzenes; Ovarian Neoplasms; Paclitaxel; Piperazines; Signal Transduction; Tumor Microenvironment | 2020 |
T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication.
Topics: Animals; Antiviral Agents; Calcium Channel Blockers; Calcium Channels, T-Type; Calcium Signaling; Chlorocebus aethiops; Dihydropyridines; Gene Expression Regulation, Viral; HeLa Cells; Herpes Genitalis; Herpesvirus 2, Human; Host-Pathogen Interactions; Humans; Piperazines; Vero Cells; Virus Replication | 2021 |
Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro.
Topics: Alkaline Phosphatase; Animals; Antihypertensive Agents; Bone Morphogenetic Protein 2; Cell Cycle; Cell Proliferation; Cells, Cultured; Dihydropyridines; Mice; Osteoblasts; Osteogenesis; Smad Proteins; Stem Cells | 2021 |
Computational drug repositioning for ischemic stroke: neuroprotective drug discovery.
Topics: Algorithms; Animals; Apoptosis; Cell Line; Computational Biology; Dihydropyridines; Drug Discovery; Drug Repositioning; Humans; Ischemic Stroke; Mice; Neuroprotective Agents; Nifedipine; Oxidative Stress | 2021 |
An antihypertensive agent benidipine is an effective neuroprotective and antiepileptic agent: an experimental rat study.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Brain; Dihydropyridines; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Wistar; Valproic Acid | 2021 |
Effect of adenosine triphosphate, benidipine and their combinations on bevacizumab-induced kidney damage in rats.
Topics: Adenosine Triphosphate; Animals; Bevacizumab; Dihydropyridines; Kidney; Malondialdehyde; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A | 2021 |
Gingival enlargement improvement following medication change from amlodipine to benidipine and periodontal therapy.
Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Female; Gingival Hyperplasia; Gingival Overgrowth; Humans; Hypertension | 2022 |
Sensitivity Enhanced Ecofriendly UV Spectrophotometric Methods for Quality Control of Telmisartan and Benidipine Formulations: Comparison of Whiteness and Greenness with HPLC Methods.
Topics: Chromatography, High Pressure Liquid; Dihydropyridines; Quality Control; Spectrophotometry; Telmisartan | 2022 |