benfluorex and fenfluramine

benfluorex has been researched along with fenfluramine in 144 studies

Research

Studies (144)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (10.42)	18.7374
1990's	37 (25.69)	18.2507
2000's	17 (11.81)	29.6817
2010's	74 (51.39)	24.3611
2020's	1 (0.69)	2.80

Authors

Authors	Studies
Bowley, M; Brindley, DN; Burditt, SL; Cooling, J; Glenny, HP; Lawson, N; Pritchard, PH; Sturton, RG	1
Asmal, AC; Deppe, W; Leary, WP; Lockett, CJ	1
Brindley, DN	2
Sodoyez, JC; Sodoyez-Goffaux, F	2
Da Tos, V; Del Prato, S; Dorella, M; Riccio, A; Vigili de Kreutzenberg, S	1
Brun, JM	1
Bailey, CJ; Day, C; Page, T; Thornburn, CC	1
Arnaud, O; Auclair, M; Mazière, C; Mazière, JC; Mora, L	1
al-Sieni, AI; Brindley, DN; Hales, P; Russell, JC	1
Duthel, JM; Franceschini, A; Vallon, JJ	1
Boine, L; Cavallo-Perin, P; Cobelli, C; Estivi, P; Galletti, R; Pacini, G; Pagano, G	1
di Martino, G; Federico, P; Jacono, G; Mattera, E	1
Akester, H; Brindley, DN; Derrick, GP; Finnerty, C; Irvine, CD; Macdonald, IA; Patmore, RD; Saxton, J; Spencer, H; Yule-Smith, A	1
Di Fede, G; Renda, G; Rini, GB	1
Ranquin, R	1
Berruto, M; Blasi, F; Cosentini, R; Sommariva, D	1
Beynen, AC; Geelen, MJ	1
Bereksi-Reguig, K; Escousse, A; Goudonnet, H; Mounié, J; Truchot, R	1
Debeer, LJ; Declercq, PE; Mannaerts, GP; Van Veldhoven, P	1
Bichi, LA; Franklin, CS; Slusarczyk, H; Turner, P	1
Geelen, MJ	1
Glikmanas, M; Tramoni, M	1
Brems, HM; De Witte, P	1
Glikmanas, M	1
Bourdeaux, M; Chauvet, M; Dell'Amico, M; Lafont, H; Orsière, T	1
Beer, NA; Beer, RM; Colombo, C; Jakubowicz, DJ; Nestler, JE	1
Geelen, MJ; Schmitz, MG; Tielens, AG; van den Heuvel, JM	1
Da Tos, V; De Biasi, L; Del Prato, S; Dorella, M; Marescotti, MC; Riccio, A; Tiengo, A; Vigili de Kreutzenberg, S	1
Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW	2
Bolli, GB; De Feo, P; De Gregoris, P; Lavielle, R	1
Bailbé, D; Blondel, O; Picarel, F; Portha, B; Serradas, P	1
Cooney, GJ; Kusunoki, M; Pan, DA; Storlien, LH	1
Arnaud, O; Duhault, J; Espinal, J; Lacour, F	1
Jenkins, AB; Kusunoki, M; Oakes, ND; Pan, DA; Storlien, LH	1
Bailbe, D; Blondel, O; Portha, B; Serradas, P	1
Bourdeaux, MJ; Chauvet, MM; Dell'Amico, MH; Orsière, TG	1
Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G	1
Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC	1
Camps, M; Castelló, A; Chillarón, J; Furriols, M; Muñoz, P; Palacín, M; Testar, X; Zorzano, A	1
Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC; Wood, GO	1
Ravel, D	1
Fields, M; Lewis, CG	1
Bauduceau, B; Brun, JM; Guillon-Metz, F; Leutenegger, M; Martin, C; Nicolino-Peltier, C; Richard, JL; Vannereau, D	1
Bennani, N; El Madani, T; Hadjiisky, P; Marquié, G; Pieraggi, MT; Ravel, D; Seguin, L; Solera, ML	1
Bonerandi, JJ; Chaine, B; Folchetti, G; Hesse, S; Jean-Pastor, MJ; Morand, JJ	1
Drain, P	1
Gumà, A; Muñoz, P; Palacín, M; Sevilla, L; Testar, X; Zorzano, A	1
Andres, E; Blicklé, JF; Brogard, JM; Neyrolles, N	1
Bazex, J; Loche, F; Thouvenin, MD	1
Girard, J; Kohl, C; Pégorier, JP; Ravel, D	1
Anguera Ferrando, N; Batalla Sahún, N; Casañas Muñoz, R; Castro Cels, A; Pujadas Capmany, R; Rafel Ribera, J	1
Del Prato, S; Erkelens, DW; Leutenegger, M	1
Cerea, M; Conte, U; Gazzaniga, A; Maroni, A; Sangalli, ME; Zema, L	1
Bouchard, C; Brás, A; Eilers, M; Marquardt, J; Medema, RH	1
Gao, C; Milgrom, E; Shen, WC; Wang, L	1
Brezina, V; Horn, CC; Weiss, KR	1
Larschan, E; Winston, F	1
Peterson, CL; Wolner, B	1
Balamotis, MA; Berk, AJ; Handa, H; Stevens, JL; Wang, G; Yamaguchi, Y	1
Alawi, H; Andre, M; dos Santos, LC; Francillard, M; Khalid, AK; Koev, D; Moore, R; Moulin, P; Picandet, B; Serban, V	2
Bagheri, H; Bruneval, P; Montastruc, JL; Moreau, M; Noize, P; Pathak, A; Sauer, M	1
Boutet, K; Carlhant-Kowalski, D; Frachon, I; Gut-Gobert, C; Humbert, M; Jobic, Y; Leroyer, C; Simonneau, G; Sitbon, O	1
Ozer, C; Sari Kiliçaslan, SM	1
Andréjak, M; Caus, T; Henon, P; Leleu, F; Peltier, M; Rusinaru, D; Sevestre, H; Tribouilloy, C; Tribouilloy, L	1
Maccaroni, E; Malpezzi, L; Masciocchi, N; Panzeri, W	1
Etienne, Y; Frachon, I; Humbert, M; Jobic, Y; Le Gal, G; Leroyer, C	1
Gueffet, JP; Piriou, N; Trochu, JN	1
Cai, K; Caruthers, SD; Huang, W; Lanza, GM; Wickline, SA; Williams, TA; Winter, PM; Zhang, H	1
Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A	1
Beuck, S; Gougoulidis, V; Kwiatkowska, D; Pokrywka, A; Schänzer, W; Schlörer, N; Sigmund, G; Thevis, M; Thomas, A	1
Benkimoun, P	3
Cosyns, B; Droogmans, S; Van Camp, G	1
Blanchard-Lemoine, B; Eicher, JC; Etienne, Y; Gueffet, JP; Habib, G; Hénon, P; Jobic, Y; Le Ven, F; Maréchaux, S; Rousseau, J; Tribouilloy, C	1
Braillon, A	2
Casassus, B	1
Mullard, A	2
Nau, JY	4
Hill, C	1
Frachon, I	1
Mauduit, L	1
Menard, J	1
Evans, S; Waller, P	1
Canet, E; Guardiola, B; Tsouderos, Y; Vincent, L	1
Castellant, P; Etienne, Y; Fatemi, M; Frachon, I; Jobic, Y; Quintin-Roué, I	1
Avierinos, JF; Boudes, A; Habib, G; Lavoute, C; Le Dolley, Y; Loundou, AD; Michel, N; Renard, S; Salem, A; Villacampa, C	1
Andréjak, M; Jeu, A; Jobic, Y; Maréchaux, S; Rusinaru, D; Tribouilloy, C	1
Butler, D	1
Andréjak, M; Rusinaru, D; Tribouilloy, C	1
Kmietowicz, Z	1
Barrio, M; Céolin, R; Maccaroni, E; Malpezzi, L; Masciocchi, N; Rietveld, IB; Tamarit, JL	1
Fournier, A; Zureik, M	1
Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L	1
Bergot, E; Bourdin, A; Chaumais, MC; Cottin, V; Dromer, C; Frachon, I; Habib, G; Humbert, M; Jaïs, X; Lamblin, N; Montani, D; Pison, C; Poubeau, P; Prevot, G; Reynaud-Gaubert, M; Sanchez, O; Savale, L; Simonneau, G; Sitbon, O; Tubert-Bitter, P	1
Damase-Michel, C; Hurault-Delarue, C; Lacroix, I; Montastruc, JL	1
Bruckert, E; Derumeaux, G; Ernande, L; Gavini, F; Moulin, P; Picandet, B; Rousset, H; Senn, S; Serusclat, A; Servan, E; Van Gaal, L	1
Watson, R	1
Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Tribouilloy, C	1
Frachon, I; Hill, C; Nicot, P	1
Athavankar, S; Cohen, T; Kiselyuk, A; Lee, SH; Levine, F; Piran, R	1
Andréjak, M; Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Tribouilloy, C	1
Borer, JS	1
Abou Taam, M; Bagheri, H; Bouscaren, N; Cantaloube, L; Herxheimer, A; Montastruc, F; Montastruc, JL; Pochard, L; Roche, G; Rossard, C	1
Andréjak, M; Maréchaux, S; Peltier, M; Szymanski, C; Tribouilloy, C	1
Bruneval, P; Ennezat, PV; Etienne, Y; Jobic, Y	1
Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Szymanski, C; Tribouilloy, C	1
Assoun, B; Augier, C; Bruneval, P; Chavanon, O; Ennezat, PV; Lantuejoul, S; Maréchaux, S; Melloul, E; Salvat, M; Tribouilloy, C	1
Bruneval, P; Ennezat, PV; Iung, B; Jobic, Y; Plurien, F	1
Cambon, D; Leclercq, F	1
Bruneval, P; Czitrom, D; Ennezat, PV; Malergue, MC	1
Arnaud-Crozat, E; Bellemin, JP; Bruneval, P; Ennezat, PV; Fleury, JP; Maréchaux, S; Obadia, JF; Ramadan, R; Senellart, F; Touati, G; Tribouilloy, C	1
Assoun, B; Augier, C; Banfi, C; Blanchard-Lemoine, B; Bogino, E; Brochet, E; Bruneval, P; Chavanon, O; Copin, MC; Czitrom, D; Dambrin, C; du Fretay, XH; Ennezat, PV; Fabre, O; Greffe, L; Grisoli, D; Gueffet, JP; Guillou, L; Ikoli, JF; Jobic, Y; Lantuejoul, S; Malergue, MC; Maréchaux, S; Morera, P; Nazeyrollas, P; Patra, O; Petit-Eisenmann, H; Piriou, N; Remadi, JP; Roudaut, R; Tribouilloy, C; Trochu, JN; Vincentelli, A	1
Alavi, Z; Didier, R; Etienne, Y; Jobic, Y; Le Ven, F; Porcher, R	1
Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC	1
Dyer, O	1
Harris, AP; Ismail, KA; Lencinas, A; Martopullo, I; Nunez, M; Runyan, RB; Selmin, OI	1
Attias, D; Bonnet, N; Bruneval, P; Eugène, M	1
Benkebil, M; Solé, E; Trinh, NTH	1
Göldner, V; Karst, U	1

Reviews

12 review(s) available for benfluorex and fenfluramine

Article	Year
[Mode of action of benfluorex. Recent data]. Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28 Topics: Animals; Arteriosclerosis; Diabetes Mellitus, Type 2; Drug Interactions; Fatty Acids; Female; Fenfluramine; Humans; Hydrocortisone; Hyperinsulinism; Hyperlipidemias; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Obesity; Rats	1992
Short-term inhibition of fatty acid biosynthesis in isolated hepatocytes by mono-aromatic compounds. Toxicology, 1982, Volume: 24, Issue:3-4 Topics: Acetyl-CoA Carboxylase; Aminosalicylic Acid; Animals; Benzene Derivatives; Benzoates; Benzoic Acid; Carbohydrate Metabolism; Clofibrate; Coumaric Acids; Fatty Acids; Fenfluramine; Halofenate; Hydroxybenzoates; Lipids; Liver; Models, Biological; Oxidation-Reduction; Parabens; Rats; Salicylates; Salicylic Acid	1982
The peripheral actions of antiobesity drugs. International journal of obesity, 1982, Volume: 6, Issue:4 Topics: 5-Hydroxytryptophan; Animals; Appetite Depressants; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Fenfluramine; Glucose; Humans; In Vitro Techniques; Indoles; Mazindol; Muscles; Rats; Receptors, Serotonin; Serotonin	1982
Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Hypothalamus; Insulin Resistance; Models, Biological; Obesity; Syndrome	1993
Effects of benfluorex on in vivo patterns of insulin resistance induced by diets rich in fat or fructose. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet, Diabetic; Dietary Carbohydrates; Dietary Fats; Fenfluramine; Fructose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Muscles; Rats; Triglycerides	1993
[Benfluorex (Mediator) and non-insulin-dependent diabetes]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1997 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hypolipidemic Agents; Insulin	1997
[Benfluorex (Mediator): non-insulin-dependent diabetes and hypertriglyceridemia]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1998 Topics: Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hypertriglyceridemia	1998
[Current status of the treatment of type 2 diabetes mellitus. The revival of insulin-resistance drugs]. La Revue de medecine interne, 1999, Volume: 20 Suppl 3 Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exercise; Fenfluramine; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Lactones; Lipase; Metformin; Orlistat; Peroxisome Proliferators; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone	1999
Benfluorex: analysis of a drug-related public health crisis. Diabetes & metabolism, 2011, Volume: 37, Issue:3 Topics: Attitude to Health; Communications Media; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; Humans; Iatrogenic Disease; Public Health; Treatment Failure	2011
[Benfluorex and valvular heart disease]. Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11 Topics: Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Cross-Sectional Studies; Echocardiography; Female; Fenfluramine; Follow-Up Studies; France; Heart Valves; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Norfenfluramine; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals	2011
[About the settlement of litigations concerning the harm caused by benfluorex (Mediator®)]. Presse medicale (Paris, France : 1983), 2013, Volume: 42, Issue:4 Pt 1 Topics: Aortic Valve Insufficiency; Appetite Depressants; Causality; Compensation and Redress; Cross-Sectional Studies; Diagnosis, Differential; Drug Industry; Drugs, Generic; Eligibility Determination; Expert Testimony; Fenfluramine; France; Humans; Mitral Valve Insufficiency; Probability; Risk Factors	2013
Adverse effects of benfluorex on heart valves and pulmonary circulation. Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:7 Topics: Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary; Hypolipidemic Agents; Norfenfluramine; Pulmonary Circulation; Randomized Controlled Trials as Topic; Receptor, Serotonin, 5-HT2B	2014

Trials

16 trial(s) available for benfluorex and fenfluramine

Article	Year
[Mechanisms of hypoglycemic action of benfluorex]. Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28 Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Fenfluramine; Fructosamine; Glycated Hemoglobin; Hexosamines; Humans; Hypolipidemic Agents; Insulin; Liver; Male; Middle Aged	1992
[Antidiabetic efficacy of benfluorex. Clinical data]. Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28 Topics: Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Fenfluramine; Humans; Hypolipidemic Agents; Insulin; Lactates; Male; Metformin; Middle Aged; Obesity	1992
Benfluorex and blood glucose control in non insulin-dependent diabetic patients. Journal of endocrinological investigation, 1991, Volume: 14, Issue:2 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fenfluramine; Humans; Hypolipidemic Agents; Islets of Langerhans; Male; Middle Aged	1991
Effects of benfluorex in obese patients with metabolic disorders. The British journal of clinical practice, 1989, Volume: 43, Issue:6 Topics: Blood Glucose; Female; Fenfluramine; Hormones; Humans; Hypolipidemic Agents; Lipids; Male; Metabolic Diseases; Middle Aged; Obesity	1989
Effects of benfluorex on patients with endogenous hypertriglyceridaemia. Current medical research and opinion, 1987, Volume: 10, Issue:8 Topics: Adult; Aged; Body Weight; Double-Blind Method; Female; Fenfluramine; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Triglycerides	1987
Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:2 Topics: Aged; Aging; Androgens; Blood Glucose; Blood Pressure; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Fenfluramine; Humans; Hydrocortisone; Hypertension; Hypolipidemic Agents; Insulin Antagonists; Male; Middle Aged; Placebos	1995
Mechanism(s) of the blood glucose lowering action of benfluorex. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Appetite Depressants; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Fenfluramine; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Male; Middle Aged; Triglycerides	1993
Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Fenfluramine; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Middle Aged; Obesity	1993
Anti-hyperglycaemic mechanisms of benfluorex in type II diabetes mellitus. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids, Nonesterified; Fenfluramine; Gluconeogenesis; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Lactates; Liver; Middle Aged	1993
Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. Diabetes care, 1993, Volume: 16, Issue:4 Topics: Apolipoprotein A-I; Apolipoproteins B; Appetite Depressants; Blood Glucose; C-Peptide; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fenfluramine; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Lipids; Middle Aged; Multivariate Analysis; Obesity; Placebos; Triglycerides	1993
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:10 Topics: 3-Hydroxybutyric Acid; Appetite Depressants; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids, Nonesterified; Fenfluramine; Glucose; Glycerol; Humans; Hydroxybutyrates; Insulin; Insulin Resistance; Insulin Secretion; Middle Aged; Obesity; Placebos	1996
Added benfluorex in obese insulin-requiring type 2 diabetes. Diabetes & metabolism, 1998, Volume: 24, Issue:1 Topics: Adolescent; Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Monitoring, Physiologic; Obesity; Postprandial Period	1998
Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients. Acta diabetologica, 2003, Volume: 40, Issue:1 Topics: Appetite Depressants; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Fenfluramine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Placebos; Retreatment; Treatment Failure; Treatment Outcome	2003
Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study. Diabetes care, 2006, Volume: 29, Issue:3 Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Fenfluramine; Glycated Hemoglobin; Humans; Male; Middle Aged; Sulfonylurea Compounds	2006
Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18 to 34-week, open-label, extension period. Diabetes & metabolism, 2009, Volume: 35, Issue:1 Topics: Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fenfluramine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Placebos; Safety; Selective Serotonin Reuptake Inhibitors; Sulfonylurea Compounds; Young Adult	2009
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus. PloS one, 2012, Volume: 7, Issue:6 Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Fenfluramine; Glycated Hemoglobin; Heart Valve Diseases; Humans; Hypoglycemic Agents; Male; Middle Aged; Treatment Outcome	2012

Other Studies

116 other study(ies) available for benfluorex and fenfluramine

Article	Year
The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue. The Biochemical journal, 1977, Sep-15, Volume: 166, Issue:3 Topics: Adipose Tissue; Animals; Ethanol; Fenfluramine; Glucose; Glycerides; Glycolipids; Liver; Male; Rats	1977
The effects of benfluramate on carbohydrate metabolism in obesity. Research communications in chemical pathology and pharmacology, 1977, Volume: 18, Issue:1 Topics: Adult; Blood Glucose; Body Weight; Carbohydrate Metabolism; Female; Fenfluramine; Humans; Kinetics; Lactates; Male; Obesity; Oxidation-Reduction	1977
[Effects of chronic administration of benfluorex on the pharmacokinetics of iodine 123 labelled insulin in Zucker obese rats (fa/fa)]. Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28 Topics: Administration, Oral; Animals; Fenfluramine; Hypolipidemic Agents; Insulin; Insulin Resistance; Iodine Radioisotopes; Kidney; Liver; Rats; Rats, Zucker	1992
Acute effect of benfluorex on glucose metabolism. Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2 Topics: Animals; Blood Glucose; Fenfluramine; Glucose; Glycogen; Hypolipidemic Agents; Insulin; Liver; Male; Muscles; Rats; Rats, Inbred Strains	1992
The liver metabolite S-422 of the hypolipidaemic drug benfluorex decreases cholesterol esterification in fibroblasts and monocyte-like cells. European journal of clinical pharmacology, 1991, Volume: 41, Issue:4 Topics: Acyl Coenzyme A; Apolipoproteins; Cholesterol; Cholesterol Esters; Esterification; Fenfluramine; Fibroblasts; Humans; Hypolipidemic Agents; Lipoproteins, LDL; Liver; Oleic Acid; Oleic Acids; Receptors, Cell Surface; Receptors, Lipoprotein	1991
Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex. Biochimica et biophysica acta, 1991, Aug-20, Volume: 1085, Issue:1 Topics: Adipose Tissue; Animals; Body Weight; Feeding Behavior; Female; Fenfluramine; Glucose; Hormones; Hypolipidemic Agents; Insulin; Lipids; Male; Obesity; Rats; Triglycerides	1991
[Specific detection of urinary sympathomimetic amines for control of anti-doping by gas chromatography-mass spectroscopy]. Journal of chromatography, 1991, Mar-22, Volume: 541, Issue:1-2 Topics: Amphetamines; Benzphetamine; Doping in Sports; Fenfluramine; Gas Chromatography-Mass Spectrometry; Humans; Sympathomimetics	1991
Effects of chronic administration of benfluorex to rats on the metabolism of corticosterone, glucose, triacylglycerols, glycerol and fatty acid. Biochemical pharmacology, 1988, Feb-15, Volume: 37, Issue:4 Topics: Animals; Appetite Depressants; Blood Glucose; Body Weight; Corticosterone; Eating; Fatty Acids; Fenfluramine; Glucose; Glycerol; Lipoprotein Lipase; Male; Rats; Rats, Inbred Strains; Triglycerides	1988
Possibilities for the management of multiple metabolic disorders with benfluorex. Bollettino della Societa italiana di biologia sperimentale, 1987, Apr-30, Volume: 63, Issue:4 Topics: Adult; Appetite Depressants; Fenfluramine; Humans; Male; Metabolic Diseases; Middle Aged	1987
Effects of benfluorex on sterol biosynthesis in incubated human blood mononuclear cells. Drugs under experimental and clinical research, 1986, Volume: 12, Issue:11 Topics: Blood Cells; Fenfluramine; Humans; In Vitro Techniques; Mevalonic Acid; Sterols	1986
[Inductive effects of N-(benzoyloxy-2-ethyl)norfenfluramine (benfluorex) on hepatic microsomal enzymes in rats]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1983, Volume: 177, Issue:4 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Fenfluramine; Glucosyltransferases; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1983
Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver. Biochemical pharmacology, 1984, Apr-01, Volume: 33, Issue:7 Topics: Animals; Catalase; Fenfluramine; Fenofibrate; Glutamate Dehydrogenase; Hypolipidemic Agents; Liver; Male; Microbodies; Mitochondria, Liver; Propionates; Rats; Rats, Inbred Strains	1984
Mechanisms responsible for the inhibitory effects of benfluorex on hepatic intermediary metabolism. Biochemical pharmacology, 1983, Jun-01, Volume: 32, Issue:11 Topics: Animals; Benzoates; Benzoic Acid; Energy Metabolism; Fatty Acid Synthases; Fatty Acids; Female; Fenfluramine; Glucose; Glycine; In Vitro Techniques; Male; Mitochondria, Liver; Pyruvates; Rats; Rats, Inbred Strains	1983
[Value of benfluorex in the treatment of metabolic disorders associated with diabetes]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1981 Topics: Diabetes Complications; Fenfluramine; Humans; Metabolic Diseases	1981
Co-administration of benfluorex with oral anticoagulant therapy. Current medical research and opinion, 1980, Volume: 6, Issue:7 Topics: Administration, Oral; Adult; Aged; Anticoagulants; Drug Interactions; Female; Fenfluramine; Heart Diseases; Humans; Male; Middle Aged; Prothrombin Time	1980
[Efficacy of benfluorex in the treatment of multiple metabolic overloads: preliminary results concerning 1609 cases]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1980 Topics: Body Weight; Carbohydrate Metabolism; Fenfluramine; Humans; Hypolipidemic Agents; Lipid Metabolism; Metabolic Diseases	1980
In vitro influence of benfluorex and its main metabolites on rat liver microsomal membrane properties. Chemico-biological interactions, 1995, Aug-18, Volume: 97, Issue:3 Topics: Animals; Benzoates; Benzoic Acid; Cholesterol Esters; Fenfluramine; Fluorescent Dyes; Hypolipidemic Agents; Lipid Metabolism; Male; Membrane Fluidity; Microsomes, Liver; Molecular Structure; Rats; Rats, Wistar; Sterol O-Acyltransferase	1995
Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats. Biochemical pharmacology, 1993, Nov-02, Volume: 46, Issue:9 Topics: Aging; Animals; Body Weight; Fenfluramine; Glucose; Glycogen; Insulin; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylases; Rats; Rats, Sprague-Dawley	1993
Insulin resistance, hyperinsulinemia and diabetes--contribution of benfluorex. Prague, 11 September 1992. Symposium proceedings. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Animals; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance	1993
Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fenfluramine; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Rats; Rats, Wistar; Time Factors	1993
Effect of chronic benfluorex treatment on interaction of insulin 123I with liver receptors in fa/fa Zucker rats. Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1 Topics: Animals; Blood Glucose; Fatty Acids, Nonesterified; Fenfluramine; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Iodine Radioisotopes; Islets of Langerhans; Kidney; Liver; Organ Size; Rats; Rats, Zucker; Receptor, Insulin; Recombinant Proteins; Reference Values; Triglycerides	1993
Improvement in glucose tolerance of insulin resistant rats after chronic or acute administration of benfluorex. Life sciences, 1993, Volume: 53, Issue:20 Topics: Administration, Oral; Animals; Blood Glucose; Drug Administration Schedule; Fenfluramine; Glucose Intolerance; Glucose Tolerance Test; Hypolipidemic Agents; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Time Factors	1993
Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex. Diabetes, 1993, Volume: 42, Issue:3 Topics: Analysis of Variance; Animals; Diet; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Fenfluramine; Fructose; Glucose Clamp Technique; Hypolipidemic Agents; Insulin Resistance; Male; Rats; Rats, Wistar; Starch; Syndrome	1993
Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. Diabetes, 1993, Volume: 42, Issue:4 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Fenfluramine; Glucose Clamp Technique; Hyperglycemia; Hypolipidemic Agents; Insulin; Insulin Resistance; Liver; Rats; Rats, Wistar; Reference Values	1993
Effects of benfluorex metabolites on membrane fluidity and insulin-related processes. European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3 Topics: Animals; Cells, Cultured; Fenfluramine; Hypolipidemic Agents; Insulin; Liver; Male; Membrane Fluidity; Rats; Rats, Wistar	1995
Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat. Canadian journal of physiology and pharmacology, 1996, Volume: 74, Issue:8 Topics: Animals; Body Weight; Disease Models, Animal; Eating; Female; Fenfluramine; Hypolipidemic Agents; Insulin; Male; Obesity; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Triglycerides	1996
Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats. Biochemical pharmacology, 1996, Dec-13, Volume: 52, Issue:11 Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Fenfluramine; Glucose Transporter Type 4; Hypoglycemic Agents; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin	1996
Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats. Atherosclerosis, 1997, Jul-25, Volume: 132, Issue:2 Topics: Animals; Arteriosclerosis; Fenfluramine; Hypolipidemic Agents; Insulin Resistance; Male; Obesity; Rats; Rats, Mutant Strains	1997
Benfluorex, a hypotriglyceridemic drug, reduces lipid peroxidation and alleviates adverse metabolic complications of copper deficiency. Nutrition (Burbank, Los Angeles County, Calif.), 1997, Volume: 13, Issue:10 Topics: Amylases; Analysis of Variance; Animals; Body Weight; Cohort Studies; Copper; Diet; Fasting; Fenfluramine; Fructose; Heart; Hematocrit; Hypertriglyceridemia; Hypolipidemic Agents; Insulin; Iron; Lipid Peroxidation; Liver; Male; Organ Size; Pancreas; Random Allocation; Rats; Triglycerides	1997
Metabolic and anti-atherogenic effects of long-term benfluorex in dyslipidemic insulin-resistant sand rats (Psammomys obesus). Life sciences, 1998, Volume: 63, Issue:1 Topics: Animal Nutritional Physiological Phenomena; Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol, Dietary; Female; Fenfluramine; Gerbillinae; Glucose Tolerance Test; Hyperlipidemias; Hypolipidemic Agents; Insulin Resistance; Lipids; Liver; Male; Rats	1998
[Urticaria and anaphylactic shock from benfluorex. Two case reports]. Annales de dermatologie et de venereologie, 1998, Volume: 125, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Anaphylaxis; Appetite Depressants; Female; Fenfluramine; France; Humans; Middle Aged; Obesity; Urticaria	1998
Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding. Life sciences, 1999, Volume: 64, Issue:1 Topics: Aging; Animals; Biological Transport; Blood Glucose; Blotting, Northern; Body Weight; Deoxyglucose; Dietary Fats; Energy Intake; Fenfluramine; Glucose Transporter Type 4; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley	1999
Pityriasis-rosea-like eruption due to benfluorex. Dermatology (Basel, Switzerland), 2000, Volume: 201, Issue:1 Topics: Adult; Drug Eruptions; Female; Fenfluramine; Humans; Hypolipidemic Agents; Pityriasis Rosea	2000
Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes, 2002, Volume: 51, Issue:8 Topics: Acetyl Coenzyme A; Animals; Carnitine O-Palmitoyltransferase; Fasting; Fatty Acids; Fenfluramine; Gene Expression Regulation, Enzymologic; Glucokinase; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Hydroxymethylglutaryl-CoA Synthase; Lactates; Liver; Oxidation-Reduction; Pyruvate Kinase; Pyruvates; Rats; RNA, Messenger; Serotonin Agents; Transcription, Genetic	2002
[Valvular heart disease associated with benfluorex]. Revista espanola de cardiologia, 2003, Volume: 56, Issue:2 Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Middle Aged; Treatment Outcome	2003
A study on the release mechanism of drugs from hydrophilic partially coated perforated matrices. Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:9 Topics: Chemistry, Pharmaceutical; Drug Compounding; Fenfluramine; Hypromellose Derivatives; Kinetics; Methylcellulose; Metoprolol; Solubility; Solvents; Tablets; Time Factors	2003
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. The EMBO journal, 2004, Jul-21, Volume: 23, Issue:14 Topics: Animals; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Cyclin D2; Cyclins; Fenfluramine; Fibroblasts; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Genes, ras; Mice; NIH 3T3 Cells; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Positive Transcriptional Elongation Factor B; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Rats; Retroviridae; Signal Transduction; Transcription Factor TFIIH; Transcription Factors; Transcription Factors, TFII	2004
On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces cerevisiae: evidence for enhanced recruitment of coactivators and altered nucleosome structures. The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41 Topics: ATP-Binding Cassette Transporters; Blotting, Northern; Chromatin; DNA; DNA-Binding Proteins; Fenfluramine; Fungal Proteins; Histones; Immunoprecipitation; Micrococcal Nuclease; Models, Genetic; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; TATA-Box Binding Protein; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation	2004
Modeling neuromuscular modulation in Aplysia. III. Interaction of central motor commands and peripheral modulatory state for optimal behavior. Journal of neurophysiology, 2005, Volume: 93, Issue:3 Topics: Action Potentials; Animals; Aplysia; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Fenfluramine; Models, Biological; Motor Neurons; Muscle Contraction; Neuromuscular Junction; Neuropeptides; Nonlinear Dynamics; Peptides; Potassium; Time Factors	2005
The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription. Molecular and cellular biology, 2005, Volume: 25, Issue:1 Topics: Blotting, Northern; Caffeine; Chromatin; Chromatin Immunoprecipitation; Cloning, Molecular; Cross-Linking Reagents; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; Fenfluramine; Galactokinase; Galactose; Genetic Complementation Test; Glucose; Immunoprecipitation; Models, Biological; Mutation; Phenotype; Plasmids; Promoter Regions, Genetic; Protein Binding; RNA; RNA Polymerase III; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription Factors; Transcription, Genetic; Up-Regulation	2005
ATP-dependent and ATP-independent roles for the Rad54 chromatin remodeling enzyme during recombinational repair of a DNA double strand break. The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Blotting, Southern; Chromatin; DNA; DNA Damage; DNA Helicases; DNA Repair; DNA Repair Enzymes; Fenfluramine; Fungal Proteins; Genome; Humans; Hydrolysis; Immunoprecipitation; Micrococcal Nuclease; Models, Genetic; Plasmids; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Time Factors	2005
Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Molecular cell, 2005, Mar-04, Volume: 17, Issue:5 Topics: Acetylation; Animals; Chromatin; Chromatin Immunoprecipitation; DNA Primers; DNA-Binding Proteins; Early Growth Response Protein 1; Escherichia coli; Fenfluramine; Histones; Immediate-Early Proteins; MAP Kinase Signaling System; Methylation; Mice; Mice, Transgenic; Models, Biological; Models, Genetic; Mutation; Oligonucleotide Array Sequence Analysis; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Temperature; Transcription Factors; Transcription, Genetic	2005
Valvular heart disease in a patient taking benfluorex. Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:6 Topics: Female; Fenfluramine; Glucose Intolerance; Humans; Middle Aged; Mitral Valve Insufficiency; Tricuspid Valve Insufficiency	2006
Fenfluramine-like cardiovascular side-effects of benfluorex. The European respiratory journal, 2009, Volume: 33, Issue:3 Topics: Appetite Depressants; Cardiovascular Diseases; Diabetes Mellitus; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Mitral Valve; Overweight; Selective Serotonin Reuptake Inhibitors	2009
Effects of benfluorex-vitamin C supplementation on cutaneous capillaries of diabetic rats. Cell biology international, 2009, Volume: 33, Issue:3 Topics: Animals; Ascorbic Acid; Capillaries; Dermis; Diabetes Mellitus, Experimental; Dietary Supplements; Disease Models, Animal; Endothelial Cells; Fenfluramine; Hypolipidemic Agents; Rats; Rats, Wistar	2009
Benfluorex: negative data in France, but still on the market. Neuropsychiatric disorders, pulmonary hypertension and heart valve damage. Prescrire international, 2009, Volume: 18, Issue:101 Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Nervous System Diseases	2009
Restrictive organic mitral regurgitation associated with benfluorex therapy. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2010, Volume: 11, Issue:7 Topics: Aged; Appetite Depressants; Body Mass Index; Cardiomyopathy, Restrictive; Diabetes Mellitus; Drug Therapy, Combination; Dyslipidemias; Echocardiography, Doppler, Color; Female; Fenfluramine; Hospitals, University; Humans; Male; Medical Records; Middle Aged; Mitral Valve Insufficiency; Obesity; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Time Factors	2010
Thermal and X-ray powder diffraction structural characterization of two benfluorex hydrochloride polymorphs. Journal of pharmaceutical and biomedical analysis, 2010, Sep-21, Volume: 53, Issue:1 Topics: Chemistry, Pharmaceutical; Crystallization; Differential Thermal Analysis; Drug Stability; Fenfluramine; Models, Molecular; Molecular Structure; Phase Transition; Powder Diffraction; X-Ray Diffraction	2010
Benfluorex and unexplained valvular heart disease: a case-control study. PloS one, 2010, Apr-12, Volume: 5, Issue:4 Topics: Aged; Case-Control Studies; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents; Male; Middle Aged; Mitral Valve Insufficiency; Odds Ratio; Retrospective Studies; Single-Blind Method	2010
Benfluorex: increasing reports of valve disorders. Prescrire international, 2010, Volume: 19, Issue:105 Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Product Recalls and Withdrawals	2010
Valvular heart disease associated with benfluorex. Archives of cardiovascular diseases, 2010, Volume: 103, Issue:5 Topics: Appetite Depressants; Diuretics; Echocardiography, Doppler, Color; Female; Fenfluramine; Furosemide; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Hypolipidemic Agents; Middle Aged; Treatment Outcome	2010
MR molecular imaging of aortic angiogenesis. JACC. Cardiovascular imaging, 2010, Volume: 3, Issue:8 Topics: Animals; Aorta; Appetite Depressants; Atherosclerosis; Body Weight; Cholesterol; Disease Models, Animal; Eating; Fenfluramine; Insulin; Integrin alphaVbeta3; Leptin; Magnetic Resonance Angiography; Male; Metabolic Syndrome; Nanoparticles; Neovascularization, Pathologic; Obesity; Rats; Time Factors; Triglycerides	2010
Benfluorex: yet more valve disorders. Prescrire international, 2010, Volume: 19, Issue:107 Topics: Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents	2010
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:12 Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; Diabetes Mellitus; Female; Fenfluramine; France; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Hospitalization; Humans; Male; Medical Record Linkage; Middle Aged; Mitral Valve Insufficiency; Pharmacoepidemiology; Risk	2010
Screening for benfluorex and its major urinary metabolites in routine doping controls. Analytical and bioanalytical chemistry, 2011, Volume: 401, Issue:2 Topics: Chromatography, Liquid; Doping in Sports; Fenfluramine; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Performance-Enhancing Substances; Reference Standards; Sensitivity and Specificity; Substance Abuse Detection; Tandem Mass Spectrometry	2011
French doctors demand to know why drug stayed on the market for so long. BMJ (Clinical research ed.), 2010, Dec-03, Volume: 341 Topics: Attitude of Health Personnel; Diabetes Mellitus, Type 2; Fenfluramine; France; Humans; Hypoglycemic Agents; Safety-Based Drug Withdrawals	2010
Benfluorex: EU marketing authorisation finally withdrawn. Prescrire international, 2010, Volume: 19, Issue:109 Topics: European Union; Fenfluramine; France; Hypolipidemic Agents; Legislation, Drug; Marketing	2010
Benfluorex: the last chapter of drug-induced valvular heart disease? European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4 Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Europe; Fenfluramine; France; Guanfacine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Multicenter Studies as Topic; Quinidine; United States	2011
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4 Topics: Appetite Depressants; Body Mass Index; Comorbidity; Dose-Response Relationship, Drug; Echocardiography, Transesophageal; Female; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Middle Aged; Obesity; Registries; Retrospective Studies; Risk Factors; Treatment Outcome	2011
Challenging special interest groups: whistleblowers may help. Help them! Psychotherapy and psychosomatics, 2011, Volume: 80, Issue:2 Topics: Appetite Depressants; Conflict of Interest; Drug Industry; Drug Substitution; Ethics, Medical; Europe; Fenfluramine; Health Policy; Humans; Male; Mass Screening; Prostatic Neoplasms; Quality Assurance, Health Care; Safety Management; Safety-Based Drug Withdrawals; Societies, Medical; Urology; Whistleblowing	2011
Drug scandal exposes French regulators to public ire. Nature medicine, 2011, Volume: 17, Issue:2 Topics: Drug and Narcotic Control; Drug Industry; Fenfluramine; France; Humans; Hypoglycemic Agents	2011
Mediator scandal rocks French medical community. Lancet (London, England), 2011, Mar-12, Volume: 377, Issue:9769 Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidemic Agents; Legislation, Drug; Marketing; Safety-Based Drug Withdrawals	2011
[What were the indications for the Mediator in 1979?]. Revue medicale suisse, 2011, Feb-09, Volume: 7, Issue:281 Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Obesity; Safety-Based Drug Withdrawals	2011
[Number of deaths attributable to benfluorex]. Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:5 Topics: Cause of Death; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; Humans; Hypolipidemic Agents	2011
[Benfluorex (Mediator®), our vigilance in question]. Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:5 Topics: Appetite Depressants; Fenfluramine; Humans; Product Surveillance, Postmarketing	2011
Benfluorex: how many deaths? Prescrire international, 2011, Volume: 20, Issue:113 Topics: Appetite Depressants; Familial Primary Pulmonary Hypertension; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Safety-Based Drug Withdrawals	2011
[Mediator, the police of the medication in question]. Soins; la revue de reference infirmiere, 2011, Issue:754 Topics: Appetite Depressants; Fenfluramine; France; Humans; Hypolipidemic Agents; Product Surveillance, Postmarketing	2011
Mediator: who's to blame? Lancet (London, England), 2011, Jun-11, Volume: 377, Issue:9782 Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Humans; Hypolipidemic Agents; Legislation, Drug; Safety-Based Drug Withdrawals	2011
Mediator: who's to blame? Lancet (London, England), 2011, Jun-11, Volume: 377, Issue:9782 Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Humans; Legislation, Drug; Safety-Based Drug Withdrawals	2011
Mediator: who's to blame? Lancet (London, England), 2011, Jun-11, Volume: 377, Issue:9782 Topics: Appetite Depressants; Diabetes Mellitus, Type 2; Drug Industry; Fenfluramine; France; Glycated Hemoglobin; Humans; Hypolipidemic Agents; Safety-Based Drug Withdrawals	2011
Mitral and aortic valvular disease associated with benfluorex use. The Journal of heart valve disease, 2011, Volume: 20, Issue:3 Topics: Aortic Valve; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents; Middle Aged; Mitral Valve; Ultrasonography	2011
[The French are wary of their drugs]. Revue medicale suisse, 2011, May-25, Volume: 7, Issue:296 Topics: Appetite Depressants; Body Mass Index; Cause of Death; Drugs, Generic; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; Product Surveillance, Postmarketing	2011
Valvular heart disease associated with benfluorex therapy: high prevalence in patients with unexplained restrictive valvular heart disease. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:9 Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents; Male; Middle Aged; Mitral Valve	2011
France toughens conflict rules. Nature, 2011, Oct-11, Volume: 478, Issue:7368 Topics: Conflict of Interest; Drug Approval; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; France; Humans; Product Surveillance, Postmarketing	2011
How can benfluorex-related heart valve disease be identified by echocardiography? Archives of cardiovascular diseases, 2011, Volume: 104, Issue:10 Topics: Aortic Valve Insufficiency; Appetite Depressants; Echocardiography, Doppler, Color; Female; Fenfluramine; Humans; Hypolipidemic Agents; Mitral Valve Insufficiency; Predictive Value of Tests	2011
European drug regulator is being investigated by fraud agency. BMJ (Clinical research ed.), 2011, Nov-08, Volume: 343 Topics: Appetite Depressants; Conflict of Interest; Drug Industry; European Union; Fenfluramine; France; Fraud; Humans; London	2011
Pressure-temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: a case of enantiotropic behavior. Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:3 Topics: Crystallization; Drug Stability; Fenfluramine; Hypolipidemic Agents; Phase Transition; Pressure; Temperature	2012
Lessons from the Mediator scandal. Prescrire international, 2011, Volume: 20, Issue:122 Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Humans; Legislation, Drug; Marketing; Safety-Based Drug Withdrawals	2011
Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France. Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:4 Topics: Adult; Aged; Appetite Depressants; Cohort Studies; Databases, Factual; Female; Fenfluramine; France; Heart Valve Diseases; Hospitalization; Humans; Incidence; Male; Middle Aged	2012
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:2 Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Hypolipidemic Agents; Mitral Valve Insufficiency	2012
Appetite suppressant was probably responsible for 1300 deaths, study shows. BMJ (Clinical research ed.), 2012, Feb-09, Volume: 344 Topics: Appetite Depressants; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; France; Heart Valve Diseases; Humans	2012
Top adviser at the European Medicines Agency quits suddenly. BMJ (Clinical research ed.), 2012, Apr-11, Volume: 344 Topics: Appetite Depressants; Consultants; Drug Approval; Drug Recalls; European Union; Fenfluramine; Government Agencies; Humans; Marketing of Health Services; Product Surveillance, Postmarketing; Public Health	2012
In the wake of the Mediator scandal: some progress in France, but apathy at the European level. Prescrire international, 2012, Volume: 21, Issue:126 Topics: Drug Approval; Drug Industry; Drug-Related Side Effects and Adverse Reactions; European Union; Fenfluramine; France; Humans; Legislation, Drug; Safety-Based Drug Withdrawals	2012
Pulmonary hypertension associated with benfluorex exposure. The European respiratory journal, 2012, Volume: 40, Issue:5 Topics: Adult; Aged; Appetite Depressants; Familial Primary Pulmonary Hypertension; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Male; Middle Aged; Retrospective Studies	2012
Can benfluorex induce congenital malformations? Diabetes & metabolism, 2012, Volume: 38, Issue:4 Topics: Animals; Appetite Depressants; Female; Fenfluramine; France; Heart Defects, Congenital; Humans; Mice; Pregnancy	2012
European legislators tighten rules on drug safety. BMJ (Clinical research ed.), 2012, Sep-18, Volume: 345 Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Diabetes Mellitus, Type 2; Europe; Fenfluramine; Government Regulation; Heart Valve Diseases; Humans; Legislation, Drug; Pharmacovigilance; Product Surveillance, Postmarketing	2012
Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study. Circulation, 2012, Dec-11, Volume: 126, Issue:24 Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Diabetes Mellitus; Echocardiography; Europe; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Product Surveillance, Postmarketing; Prospective Studies; Risk Factors; Safety-Based Drug Withdrawals; Single-Blind Method	2012
Benfluorex: lesions on a bioprosthetic heart valve too. Prescrire international, 2012, Volume: 21, Issue:131 Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Bioprosthesis; Device Removal; Drug Administration Schedule; Female; Fenfluramine; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Mitral Valve Insufficiency; Prosthesis Design; Prosthesis Failure; Reoperation; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome	2012
Benfluorex: in utero exposure. Prescrire international, 2013, Volume: 22, Issue:135 Topics: Abnormalities, Drug-Induced; Appetite Depressants; Female; Fenfluramine; Humans; Organogenesis; Pregnancy; Risk Assessment; Risk Factors	2013
Benfluorex and cardiac valve disease: long delay in publication. Prescrire international, 2013, Volume: 22, Issue:135 Topics: Access to Information; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Information Dissemination; Patient Safety; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Time Factors; Ultrasonography	2013
Identification of alverine and benfluorex as HNF4α activators. ACS chemical biology, 2013, Aug-16, Volume: 8, Issue:8 Topics: Cell Line; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fenfluramine; Gene Expression Regulation; Hepatocyte Nuclear Factor 4; Humans; Models, Molecular; Molecular Structure; Propylamines; Protein Binding	2013
Mediator scandal engulfs French compensation body. Lancet (London, England), 2013, May-25, Volume: 381, Issue:9880 Topics: Compensation and Redress; Ethics, Medical; Fenfluramine; France; Humans; Hypoglycemic Agents; Safety-Based Drug Withdrawals	2013
Exposure to benfluorex: left heart valve disease very common. Prescrire international, 2013, Volume: 22, Issue:140 Topics: Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidemic Agents; Safety-Based Drug Withdrawals	2013
Frequency of drug-induced valvular heart disease in patients previously exposd to benfluorex: a multicentre prospective study. European heart journal, 2013, Volume: 34, Issue:46 Topics: Analysis of Variance; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Diabetes Mellitus; Dyslipidemias; Echocardiography; Female; Fenfluramine; Humans; Hypolipidemic Agents; Male; Middle Aged; Mitral Valve Insufficiency; Obesity; Prospective Studies; Risk Factors	2013
Drug-induced valve disease and considerations of benefit versus risk. European heart journal, 2013, Volume: 34, Issue:46 Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Humans; Hypolipidemic Agents; Male; Mitral Valve Insufficiency	2013
Analysis of patients' narratives posted on social media websites on benfluorex's (Mediator® ) withdrawal in France. Journal of clinical pharmacy and therapeutics, 2014, Volume: 39, Issue:1 Topics: Adverse Drug Reaction Reporting Systems; Communication; Female; Fenfluramine; France; Humans; Internet; Middle Aged; Safety-Based Drug Withdrawals; Social Media	2014
Identifying drug-related disorders: a probabilistic approach. Prescrire international, 2013, Volume: 22, Issue:144 Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Probability	2013
[Jacques Servier (1922-2014) or the schizophrenic metaphor of Mediator]. Revue medicale suisse, 2014, Apr-30, Volume: 10, Issue:428 Topics: Drug Industry; Fenfluramine; France; History, 20th Century; History, 21st Century; Humans	2014
Benfluorex: left heart valve disease very common. Prescrire international, 2014, Volume: 23, Issue:149 Topics: Appetite Depressants; Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans	2014
Benfluorex-induced mitral stenosis: a misknown etiology. International journal of cardiology, 2014, Dec-20, Volume: 177, Issue:3 Topics: Female; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Hypolipidemic Agents; Middle Aged; Mitral Valve Stenosis; Ultrasonography	2014
Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study. European heart journal. Cardiovascular Imaging, 2015, Volume: 16, Issue:2 Topics: Aged; Appetite Depressants; Case-Control Studies; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; United States; United States Food and Drug Administration	2015
Benfluorex: An active toxin for the development of aortic valve stenosis. International journal of cardiology, 2015, Feb-15, Volume: 181 Topics: Aged; Aortic Valve Stenosis; Appetite Depressants; Female; Fenfluramine; Humans; Middle Aged	2015
Calcifications in benfluorex-induced valve heart disease: a misknown association. Cardiology, 2015, Volume: 130, Issue:2 Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Calcinosis; Fenfluramine; Heart Valve Diseases; Humans; Male; Mitral Valve Insufficiency	2015
Clinical and echographic characteristics of patients exposed to fenfluramin or its derivatives: Results of a prospective, single-centre, observational study. Archives of cardiovascular diseases, 2015, Volume: 108, Issue:3 Topics: Aged; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Diseases; Humans; Male; Prospective Studies; Ultrasonography	2015
Fatal dynamic mitral regurgitation as a presentation of benfluorex-Induced valvular heart toxicity. International journal of cardiology, 2015, Apr-01, Volume: 184 Topics: Aged; Appetite Depressants; Autopsy; Echocardiography; Fatal Outcome; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Male; Mitral Valve; Mitral Valve Insufficiency; Obesity; Stroke Volume; Ventricular Dysfunction, Left	2015
Operative finding of aortic cusp prolapse in benfluorex-induced aortic regurgitation. International journal of cardiology, 2015, Volume: 186 Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Aortic Valve Prolapse; Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Intraoperative Period; Male; Middle Aged	2015
Drug-induced aortic valve stenosis: An under recognized entity. International journal of cardiology, 2016, Oct-01, Volume: 220 Topics: Adult; Aged; Aged, 80 and over; Aortic Valve Stenosis; Female; Fenfluramine; Humans; Male; Methysergide; Middle Aged; Retrospective Studies	2016
Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex? PloS one, 2016, Volume: 11, Issue:8 Topics: Aged; Appetite Depressants; Female; Fenfluramine; France; Heart Valve Diseases; Humans; Male; Markov Chains; Middle Aged; Rheumatic Heart Disease; Risk Factors	2016
Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. Medicine, 2017, Volume: 96, Issue:2 Topics: Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Hypertension, Pulmonary; Middle Aged; Postoperative Complications	2017
Revue medicale suisse, 2016, Sep-21, Volume: 12, Issue:531 Topics: Appetite Depressants; Blood Pressure; Fenfluramine; Genomics; Humans; Hypertension; Motion Pictures; Physicians; Professional Misconduct; Sexual Behavior	2016
France to prosecute its drug regulator and Servier in scandal over diabetes drug. BMJ (Clinical research ed.), 2017, 09-11, Volume: 358 Topics: Drug and Narcotic Control; Drug Industry; Fenfluramine; France; Fraud; Heart Valve Diseases; Homicide; Humans; Hypoglycemic Agents; Marketing; Mortality; Safety-Based Drug Withdrawals	2017
Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart. Toxicology letters, 2018, Mar-15, Volume: 285 Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Echocardiography; Environmental Pollutants; Fenfluramine; Genes, Reporter; Heart; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Humans; Myocardium; Transcription, Genetic; Trichloroethylene	2018
Benfluorex-induced severe primary tricuspid and mitral regurgitation requiring a double-valve replacement. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2018, 07-01, Volume: 54, Issue:1 Topics: Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Hypolipidemic Agents; Mitral Valve Insufficiency; Tricuspid Valve Insufficiency	2018
Benefits of combining change-point analysis with disproportionality analysis in pharmacovigilance signal detection. Pharmacoepidemiology and drug safety, 2019, Volume: 28, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Aortic Valve Insufficiency; Appetite Depressants; Data Interpretation, Statistical; Databases, Factual; Fenfluramine; France; Humans; Pharmacovigilance	2019
Benfluorex: adverse effects reviewed, 1976-2015. Prescrire international, 2017, Volume: 26, Issue:179 Topics: Appetite Depressants; Fenfluramine; France; Humans	2017
Benfluorex metabolism complemented by electrochemistry-mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2023, Oct-25, Volume: 235 Topics: Diabetes Mellitus, Type 2; Electrochemistry; Fenfluramine; Humans; Norfenfluramine; Tandem Mass Spectrometry	2023