benextramine has been researched along with cystamine in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (44.30) | 18.7374 |
| 1990's | 33 (41.77) | 18.2507 |
| 2000's | 8 (10.13) | 29.6817 |
| 2010's | 3 (3.80) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boquet, I; Kraus, JL; Laras, Y; Moret, V; Norreel, JC; Rolland, A | 1 |
| Hexum, TD; Li, W; MacDonald, RG | 2 |
| Gürdal, H; Onaran, HO; Tulunay, FC | 1 |
| McAuley, MA; Westfall, TC | 1 |
| McFarland, JW; Newcomb, DM; Olson, JA; Rice, JR; Ricketts, AP | 1 |
| Clark, JT | 1 |
| Chu, SS; Doughty, MB; Hu, L; Li, K; Tessel, R | 1 |
| Håkanson, R; Vaz, CA; Wahlestedt, C; Zukowska-Grojec, Z | 1 |
| Dieudonne, MN; Giudicelli, Y; Pecquery, R | 1 |
| Lafontan, M; Langin, D; Paris, H | 1 |
| Black, JW; Shankley, NP | 1 |
| Chu, SS; Doughty, MB; Li, K; Miller, DW; Tessel, RE | 1 |
| Tabrizchi, R; Triggle, CR | 1 |
| Koike, K; Maeda, O; Takayanagi, I | 1 |
| Andersson, RG; Grundström, N; Karlsson, JO | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Mauriege, P | 1 |
| Chan, SL; Hurst, RD; Morgan, NG | 1 |
| Hasselblatt, A; Schulz, A | 1 |
| Insel, PA; McKernan, RM; Strickland, WR | 1 |
| Purdy, RE; Weber, MA | 1 |
| Furnace, G; Hamilton, CA; Reid, JL; Sumner, DJ | 1 |
| Bond, RA; Charlton, KG; Clarke, DE | 2 |
| Angeli, P; Brasili, L; Cassinelli, A; Melchiorre, C | 1 |
| Nichols, AJ; Ruffolo, RR | 1 |
| Murray, DL; Purdy, RE; Stupecky, GL | 1 |
| Berlan, M; Lafontan, M; Taouis, M | 1 |
| Hirst, GD; Lew, MJ | 1 |
| Alvarez, M; Granados, R; Mauleón, D; Rosell, G; Salas, M; Sallés, J; Valls, N | 1 |
| Galitzky, J; Paris, H; Taouis, M | 1 |
| Furman, BL; Smith, M | 1 |
| Brasili, L; Cristalli, G; Giardinà, D; Melchiorre, C; Picchio, MT; Quaglia, W | 1 |
| de Jonge, A; Mathy, MJ; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| Angeli, P; Brancia, E; Brasili, L; Giardinà, D; Melchiorre, C; Quaglia, W | 1 |
| Belleau, B; Benfey, BG; Brasili, L; Melchiorre, C | 2 |
| Belleau, B; Benfey, BG; Benfey, TJ; Melchiorre, C | 1 |
| Belleau, B; Benfey, BG; Melchiorre, C | 1 |
| Belleau, B; Benfey, BG; Melchiorre, C; Montambault, M | 1 |
| Atlas, D; Plotek, Y | 1 |
| Coates, J; Weetman, DF | 1 |
| Gallucci, P; Melchiorre, C | 1 |
| Kirpekar, SM | 1 |
| Angus, JA; Lew, MJ | 1 |
| Angeli, P; Brancia, E; Brasili, L; Melchiorre, C | 1 |
| Chaudhry, A; Vohra, MM | 1 |
| Mottram, DR; Thakar, Y | 1 |
| Amobi, NI; Smith, IC | 1 |
| Corsi, M; Palea, S; Rimland, JM; Trist, DG | 1 |
| Hasegawa, T; Maeda, Y; Nabeshima, T; Yamada, K | 1 |
| Bolognesi, ML; Donatini, A; Ferri, S; Melchiorre, C; Romualdi, P | 1 |
| Badia, A; Sallés, J | 1 |
| Reis, DJ; Sun, MK | 1 |
| Gastoł-Lewińska, L; Smiałowska, M; Tokarski, K | 1 |
| Chaurasia, C; Doughty, MB; Misse, G; Tessel, R | 1 |
| Elliott, SR; Pearce, WJ | 1 |
| Arletti, R; Benelli, A; Bertolini, A; Menozzi, B; Poggioli, R | 1 |
| Chaurasia, CS; Doughty, MB; Li, K | 1 |
| Glavin, GB; Penner, SB; Smyth, DD | 1 |
| Ernst, S; Lyte, M | 1 |
| Dong, X; Doughty, MB; Miller, DW; Misse, GA; Tessel, RE | 1 |
| Docherty, JR; Kearns, S; O'Rourke, M | 1 |
| Corsi, M; Palea, S; Ratti, E; Rimland, JM; Trist, DG | 1 |
| Saxena, PR; Stam, WB; Van der Graaf, PH | 1 |
| Daniels, AJ; Harrington, WW; Hashim, MA; Leban, JJ; Matthews, J; Spaltenstein, A; Tadepalli, AS | 1 |
| Martin, JR | 1 |
| Beer, MS; Stanton, JA | 1 |
| Horike, K; Houchi, H; Itoh, K; Katoh, I; Kitagawa, T; Tamaki, T; Yoshizumi, M | 1 |
| Parker, MS; Parker, SL | 1 |
| Heijnen, CJ; Kavelaars, A; Rouppe van der Voort, C; van de Pol, M | 1 |
| Berggren, PO; Bokvist, K; Buschard, K; Gromada, J; Hansen, J; Høy, M; Juhl, K; Xiao-Gang, W | 1 |
| Angeli, P; Bolognesi, ML; Buccioni, M; Marucci, G; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V | 1 |
| Amobi, NI; Guillebaud, J; Kaisary, AV; Smith, IC; Turner, E | 1 |
| Bailey, SR; Berhane, Y; Elliott, J | 1 |
| Bodenstein, J; Brink, CB; Venter, DP | 1 |
| Black, JW; Leff, P; Shankley, NP; Wood, J | 1 |
| Angus, JA; Rajasekaran, P; Wright, CE | 1 |
| Cozza, G; Di Paolo, ML; Milelli, A; Minarini, A; Minniti, E; Rosini, M; Sarno, S; Ursini, F; Zonta, F | 1 |
1 review(s) available for benextramine and cystamine
| Article | Year |
|---|---|
Support for a role for feedback regulation of norepinephrine release.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Cocaine; Cystamine; Diethylamines; Drug Synergism; Electric Stimulation; Ephedrine; Feedback; Naphthalenes; Norepinephrine; Phenoxybenzamine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Synaptic Membranes | 1984 |
78 other study(ies) available for benextramine and cystamine
| Article | Year |
|---|---|
Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.
Topics: Animals; Aza Compounds; Cell Movement; Disulfides; Drug Design; Lateral Ventricles; Macrocyclic Compounds; Mice; Neurons; Peptides, Cyclic; Polyamines | 2008 |
Role of sulfhydryl groups in Y2 neuropeptide Y receptor binding activity.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Cattle; Cystamine; Electrophoresis, Polyacrylamide Gel; Hippocampus; In Vitro Techniques; Membranes; Neuropeptide Y; Receptors, Neuropeptide Y; Receptors, Neurotransmitter; Sulfhydryl Compounds | 1992 |
Role of alpha-adrenoceptors in the effects of buspirone and 5-carboxamidotryptamine in rabbit isolated thoracic aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Buspirone; Cystamine; Dose-Response Relationship, Drug; Drug Interactions; Ketanserin; Methysergide; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Vasoconstriction | 1992 |
Possible location and function of neuropeptide Y receptor subtypes in the rat mesenteric arterial bed.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Drug Interactions; Male; Mesenteric Arteries; Neuropeptide Y; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Neuropeptide Y; Receptors, Neurotransmitter | 1992 |
Further investigation of anticoccidial activity of 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Biotransformation; Cells, Cultured; Chickens; Coccidiosis; Coccidiostats; Cystamine; Eimeria tenella; Imidazoles; Indazoles; Intestines; Ligands; Poultry Diseases; Yohimbine | 1992 |
Benextramine, a putative neuropeptide Y receptor antagonist, attenuates the termination of receptivity.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Estradiol; Female; Male; Ovariectomy; Posture; Progesterone; Rats; Receptors, Neuropeptide Y; Sexual Behavior, Animal | 1992 |
Benextramine-neuropeptide Y (NPY) binding site interactions: characterization of 3H-NPY binding site heterogeneity in rat brain.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cystamine; Male; Membranes; Molecular Sequence Data; Neuropeptide Y; Peptide YY; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Sensitivity and Specificity; Tritium | 1992 |
Benextramine irreversibly inhibits [125I]neuropeptide Y affinity labeling of the Y2 binding protein in bovine hippocampus.
Topics: Affinity Labels; Animals; Carrier Proteins; Cattle; Cross-Linking Reagents; Cystamine; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Membranes; Neuropeptide Y; Succinimides | 1991 |
Norepinephrine and neuropeptide Y: vasoconstrictor cooperation in vivo and in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Consciousness; Cystamine; Drug Synergism; Inositol Phosphates; Male; Neuropeptide Y; Norepinephrine; Prazosin; Pulmonary Artery; Radioligand Assay; Rats; Rats, Inbred Strains; Vasoconstrictor Agents | 1990 |
Evidence against the "spare" receptor nature of alpha 2-adrenoceptors in hamster white fat cells.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Cell Membrane; Cricetinae; Cyclic AMP; Cystamine; Kinetics; Male; Mesocricetus; Quinoxalines; Receptors, Adrenergic, alpha | 1990 |
Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Binding Sites; Brimonidine Tartrate; Cell Membrane; Cystamine; Dioxanes; Dioxins; Epinephrine; Female; Humans; Idazoxan; Magnesium Chloride; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Tritium; Yohimbine | 1990 |
Interpretation of agonist affinity estimations: the question of distributed receptor states.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Cystamine; Kinetics; Mathematics; Models, Biological; Muscle, Smooth, Vascular; Pargyline; Phenoxybenzamine; Potassium Chloride; Rabbits; Receptors, Cell Surface; Serotonin | 1990 |
Benextramine: a long-lasting neuropeptide Y receptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cystamine; Membranes; Rats; Rats, Inbred Strains; Receptors, Neuropeptide Y; Receptors, Neurotransmitter | 1990 |
Benextramine and nifedipine distinguish between sub-classes of alpha 1-adrenoceptors.
Topics: Animals; Blood Pressure; Body Temperature; Cystamine; Decerebrate State; Diastole; Male; Methoxamine; Nifedipine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Effect of aging on presynaptic alpha 2-adrenoceptor mechanisms in guinea pig ileum.
Topics: Aging; Animals; Clonidine; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Norepinephrine; Receptors, Adrenergic, alpha; Synapses | 1989 |
Characterization of pigment aggregating alpha 2-adrenoceptors of fish melanophores by use of different agonists after partial irreversible receptor inactivation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cystamine; Fishes; In Vitro Techniques; Melanophores; Pigments, Biological; Receptors, Adrenergic, alpha | 1989 |
Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists.
Topics: Adenosine Deaminase; Adenylyl Cyclase Inhibitors; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Brimonidine Tartrate; Cystamine; Female; Guanosine Triphosphate; Humans; Lipolysis; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Effects of benextramine on the adrenergic inhibition of insulin secretion in isolated rat pancreatic islets.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Carbachol; Cell Separation; Clonidine; Cystamine; Epinephrine; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Dual action of clonidine on insulin release: suppression, but stimulation when alpha 2-adrenoceptors are blocked.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Mice | 1989 |
Selective blockade and recovery of cell surface alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. Studies with the irreversible antagonist benextramine.
Topics: Binding, Competitive; Cell Compartmentation; Cell Membrane; Cyclic AMP; Cystamine; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Receptors, Adrenergic, alpha; Tumor Cells, Cultured; Yohimbine | 1988 |
Angiotensin II amplification of alpha-adrenergic vasoconstriction: role of receptor reserve.
Topics: Angiotensin II; Animals; Cystamine; Dose-Response Relationship, Drug; Drug Interactions; Femoral Artery; Male; Nifedipine; Norepinephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine | 1988 |
Recovery of alpha-adrenoreceptor mediated responses and binding site number after intravenous benextramine in the rabbit.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Brain; Clonidine; Cystamine; Injections, Intravenous; Male; Membranes; Phenoxybenzamine; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Spleen; Time Factors | 1985 |
Responses to norepinephrine resistant to inhibition by alpha and beta adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Nordefrin; Norepinephrine; Receptors, Adrenergic; Reserpine; Yohimbine | 1986 |
Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1986 |
The relationship between alterations in alpha 1-adrenoceptor reserve by phenoxybenzamine and benextramine and the sensitivity of cirazoline-induced pressor responses to inhibition by nifedipine.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cystamine; Denervation; Imidazoles; Male; Nifedipine; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Receptors for 5-hydroxytryptamine in rabbit blood vessels: activation of alpha adrenoceptors in rabbit thoracic aorta.
Topics: Animals; Aorta, Thoracic; Cystamine; Dose-Response Relationship, Drug; Lysergic Acid Diethylamide; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reserpine; Serotonin; Vasoconstriction; Vasomotor System | 1987 |
Alpha 2-adrenergic receptor turnover in adipose tissue and kidney: irreversible blockade of alpha 2-adrenergic receptors by benextramine.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Clonidine; Cricetinae; Cystamine; Dose-Response Relationship, Drug; Kidney; Lipid Mobilization; Male; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1987 |
Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cystamine; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Quinoxalines; Receptors, Adrenergic | 1986 |
Lack of involvement of alpha-adrenoceptors in sympathetic neural vasoconstriction in the hindquarters of the rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Electric Stimulation; Female; Gagging; Hindlimb; Male; Norepinephrine; Phenoxybenzamine; Phentolamine; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction | 1987 |
Structure-activity relationships among di- and tetramine disulfides related to benextramine.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Disulfides; Male; Norepinephrine; Rats; Stereoisomerism; Structure-Activity Relationship | 1987 |
In vitro study of alpha 2-adrenoceptor turnover and metabolism using the adenocarcinoma cell line HT29.
Topics: Adenocarcinoma; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Cell Line; Cell Membrane; Colonic Neoplasms; Cyclic AMP; Cystamine; Kinetics; Phenoxybenzamine; Prazosin; Receptors, Adrenergic, alpha; Yohimbine | 1987 |
Augmentation of glucose induced insulin secretion by pertussis vaccine, phentolamine and benextramine: involvement of mechanisms additional to prevention of the inhibitory actions of catecholamines in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Catecholamines; Clonidine; Cystamine; Epinephrine; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pertussis Toxin; Pertussis Vaccine; Phentolamine; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1988 |
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Cystamine; Epinephrine; Humans; Male; Muscle Contraction; Platelet Aggregation Inhibitors; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vas Deferens | 1988 |
Effects of the irreversible alpha-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in pithed rats.
Topics: Animals; Azepines; Clonidine; Cystamine; Decerebrate State; Diastole; Dose-Response Relationship, Drug; Imidazoles; Male; Nifedipine; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoconstriction | 1985 |
Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors.
Topics: Animals; Atrial Function; Biological Assay; Carbachol; Chemical Phenomena; Chemistry; Cystamine; Disulfides; Guinea Pigs; Histamine; Ileum; Isoproterenol; Jejunum; Male; Muscle Contraction; Polyamines; Rats; Receptors, Adrenergic, alpha; Serotonin; Structure-Activity Relationship; Trachea; Vas Deferens | 1985 |
Potentiation and inhibition of nicotinic effects on striated muscle by the tetramine disulfide benextramine.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Anura; Carbachol; Cystamine; Drug Synergism; In Vitro Techniques; Muscle Contraction; Physostigmine; Receptors, Cholinergic; Receptors, Nicotinic | 1980 |
Inhibition by the tetramine disulphide, benextramine, of cardiac chronotropic histamine H2-receptor-mediated effects.
Topics: Adrenergic alpha-Antagonists; Animals; Cimetidine; Cystamine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Time Factors | 1982 |
Presynaptic effect of clonidine antagonized by the tetramine disulphide, benextramine.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Clonidine; Cocaine; Cystamine; Female; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Neurons; Phentolamine; Synapses | 1982 |
Inhibition of adrenaline-induced platelet aggregation by the alpha-adrenoceptor blocking drug benextramine.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Collagen; Cystamine; Epinephrine; Humans; Phentolamine; Platelet Aggregation; Quinidine; Verapamil | 1982 |
Characterization of benextramine as an irreversible alpha-adrenergic blocker and as a blocker of potassium-activated calcium channels.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Calcium Channel Blockers; Cystamine; In Vitro Techniques; Potassium; Rats; Synaptosomes | 1983 |
Demonstration of alpha 1s-adrenoceptors after exposure of the rat anococcygeus to benextramine.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; In Vitro Techniques; Male; Muscle Contraction; Muscles; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1983 |
The irreversible alpha-blocker benextramine interacts with two different thiol groups.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Calcium; Cystamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Sulfhydryl Compounds; Vas Deferens | 1983 |
Reversible inhibition of neuronal uptake by benextramine, an irreversible presynaptic alpha-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Biogenic Amines; Cystamine; Desipramine; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Neurons; Norepinephrine; Phenoxybenzamine; Rabbits; Species Specificity; Sympathetic Nervous System | 1984 |
N,N''-(dithio-2,1-ethanediyl)bis[N'-(pyrrol-2-ylmethyl)-1, 6,- hexanediamine] (pyrextramine), a new irreversible alpha 1-adrenoreceptor blocking agent of the tetramine disulfide class.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Vas Deferens | 1984 |
Antagonism by the tetramine disulfide benextramine of the inhibitory effects mediated by prejunctional alpha 2-adrenoceptors and by postjunctional histamine H2 receptors in the mouse vas deferens.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; Dose-Response Relationship, Drug; Histamine; In Vitro Techniques; Male; Mice; Receptors, Adrenergic, alpha; Receptors, Histamine; Receptors, Histamine H2; Vas Deferens | 1984 |
The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nordefrin; Phenethylamines; Receptors, Adrenergic, alpha | 1984 |
Reactivation by cysteamine of vascular alpha adrenoceptors blocked by the tetramine disulfide benextramine and interaction of benextramine with phenoxybenzamine.
Topics: Animals; Aorta; Cystamine; Cysteamine; Dose-Response Relationship, Drug; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1980 |
Differential inhibition in the human vas deferens by phenoxybenzamine: a possible mechanism for its contraceptive action.
Topics: Adrenergic alpha-Antagonists; Calcium; Clonidine; Contraceptive Agents, Male; Cystamine; Humans; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Prazosin; Vas Deferens | 1995 |
Discrimination by benextramine between the NPY-Y1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein.
Topics: Animals; Culture Techniques; Cystamine; Humans; Male; Neuropeptide Y; Peptides; Rabbits; Receptors, Neuropeptide Y; Saphenous Vein; Vas Deferens | 1995 |
Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-D-aspartate-induced aversive behavior.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Calcitonin; Cystamine; GABA Antagonists; Injections, Spinal; Male; Mice; Morphine; N-Methylaspartate; Naloxone; Phentolamine; Pindolol; Piperazines; Propranolol; Receptors, Neurotransmitter; Ritanserin; Serotonin Antagonists; Tropanes | 1995 |
Binding profile of benextramine at neuropeptide Y receptor subtypes in rat brain areas.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Brain Stem; Computer Simulation; Cystamine; Diamines; Frontal Lobe; Hippocampus; Male; Parietal Lobe; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 1994 |
Selective enrichment with alpha 1A- and alpha 1B-adrenoceptor subtypes in rat brain cortical membranes.
Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Alkylation; Animals; Binding Sites; Cerebral Cortex; Clonidine; Cystamine; Dihydropyridines; Dioxanes; Phenoxybenzamine; Phentolamine; Prazosin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1994 |
Intrathecal kynurenate but not benextramine blocks hypoxic sympathoexcitation in chemodenervated anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Cystamine; Hypoxia; Injections, Spinal; Kynurenic Acid; Male; Medulla Oblongata; Muscimol; Rats; Rats, Sprague-Dawley; Spinal Cord; Stereotaxic Techniques; Sympathectomy, Chemical; Sympathetic Nervous System | 1994 |
The role of alpha-1 adrenergic receptors in the stimulating effect of neuropeptide Y (NPY) on rat behavioural activity.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Cystamine; Frontal Lobe; Male; Motor Activity; Neuropeptide Y; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1994 |
Nonpeptide peptidomimetic antagonists of the neuropeptide Y receptor: benextramine analogs with selectivity for the peripheral Y2 receptor.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cystamine; Male; Molecular Sequence Data; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Structure-Activity Relationship | 1994 |
Effects of maturation on alpha-adrenergic receptor affinity and occupancy in small cerebral arteries.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Cerebral Arteries; Cystamine; Dose-Response Relationship, Drug; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Sheep; Vasoconstriction; Yohimbine | 1994 |
Benextramine, an NPY antagonist, improves sexual behavior in male rats.
Topics: Animals; Cystamine; Female; Male; Neuropeptide Y; Rats; Rats, Wistar; Sexual Behavior, Animal | 1994 |
Benextramine-neuropeptide Y receptor interactions: contribution of the benzylic moieties to [3H]neuropeptide Y displacement activity.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Binding Sites; Brain; Cystamine; Drug Interactions; Male; Molecular Sequence Data; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Structure-Activity Relationship | 1993 |
Effects of neuropeptide Y and [Leu31,Pro34] neuropeptide Y on experimental gastric lesion formation and gastric secretion in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Gastric Acid; Gastric Mucosa; Immobilization; Ligation; Male; Neuropeptide Y; Pepsin A; Pylorus; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Stomach; Stomach Ulcer; Stress, Physiological | 1993 |
Alpha and beta adrenergic receptor involvement in catecholamine-induced growth of gram-negative bacteria.
Topics: Alprenolol; Catecholamines; Cystamine; Escherichia coli; Isoproterenol; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stereoisomerism; Yersinia enterocolitica | 1993 |
Characterization of vascular postsynaptic neuropeptide Y receptor function and regulation. 1. NPY-induced constriction in isolated rat femoral artery rings is mediated by both Y1 and Y2 receptors: evidence from benextramine protection studies.
Topics: Animals; Cystamine; Drug Antagonism; Femoral Artery; In Vitro Techniques; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Synapses; Vasoconstriction | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxathiins; Phenoxybenzamine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spiperone; Xylazine; Yohimbine | 1995 |
Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuropeptide Y; Peptide Fragments; Prostate; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Suramin; Vas Deferens | 1995 |
Benextramine acts as an irreversible noncompetitive antagonist of U46619-mediated contraction of the rat small mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Animals; Cystamine; Male; Mesenteric Arteries; Muscle Contraction; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Hemodynamic characterization of a novel neuropeptide Y receptor antagonist.
Topics: Anesthesia; Animals; Cystamine; Dogs; Hemodynamics; Hypertension; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 1996 |
Pressor effect of the putative M1 muscarinic receptor agonist MCN-A-343 in the conscious rat.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Adrenal Medulla; Adrenergic Agonists; Adrenergic Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cystamine; Drug Interactions; Guanethidine; Male; Muscarinic Agonists; Neuropeptide Y; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Yohimbine | 1996 |
Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Cell Line; Clone Cells; Cystamine; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium | 1997 |
Neuropeptide Y as a stimulator of Na+ -dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cells, Cultured; Cystamine; Heart; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Sodium | 1997 |
Ligand association with the rabbit kidney and brain Y1, Y2 and Y5-like neuropeptide Y (NPY) receptors shows large subtype-related differences in sensitivity to chaotropic and alkylating agents.
Topics: Alkylating Agents; Amiloride; Amino Acid Sequence; Animals; Brain; CHO Cells; Clonidine; Cricetinae; Cystamine; Ethylmaleimide; Gastrointestinal Hormones; GTP-Binding Protein alpha Subunits, Gs; Guinea Pigs; Humans; Hypothalamus; Kidney; Ligands; Mesylates; Molecular Sequence Data; Peptide Fragments; Peptide YY; Rabbits; Radioligand Assay; Receptors, Neuropeptide Y; Sodium Cholate; Sulfhydryl Compounds; Urea | 2000 |
Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Cells, Cultured; Cystamine; Dexamethasone; Enzyme Activation; Humans; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Monocytes; Norepinephrine; Phosphorylation; Phytohemagglutinins; Receptors, Adrenergic, alpha-1; RNA, Messenger; Transcriptional Activation; Yohimbine | 2000 |
Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells.
Topics: Adenylate Cyclase Toxin; Animals; Calcineurin; Cells, Cultured; Clorgyline; Cyclosporine; Cystamine; Diazoxide; Exocytosis; Glucagon; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Indoles; Islets of Langerhans; Male; Membrane Potentials; Nitriles; Oligodeoxyribonucleotides, Antisense; Pertussis Toxin; Phentolamine; Potassium Channels; Proto-Oncogene Proteins; Pyrethrins; Rats; Rats, Inbred Lew; Virulence Factors, Bordetella | 2001 |
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Cystamine; Disulfides; In Vitro Techniques; Male; Polyamines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Structure-Activity Relationship; Vas Deferens | 2001 |
Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens.
Topics: Adrenergic alpha-Antagonists; Cystamine; Dibenzylchlorethamine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha-1; Vas Deferens; Vasoconstrictor Agents | 2002 |
Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.
Topics: Adrenergic alpha-Agonists; Animals; Biogenic Amines; Blood Platelets; Cecum; Cystamine; Femoral Artery; Femoral Vein; Fluoxetine; Horses; In Vitro Techniques; Isometric Contraction; Ketanserin; Male; Muscle, Smooth, Vascular; Platelet Activation; Serotonin Antagonists; Vasoconstriction | 2003 |
Phenoxybenzamine and benextramine, but not 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride, display irreversible noncompetitive antagonism at G protein-coupled receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cyclic AMP; Cystamine; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Humans; Inositol Phosphates; Ligands; Phenoxybenzamine; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Second Messenger Systems; Serotonin Receptor Agonists; Signal Transduction | 2005 |
An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. 1985.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Cystamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; History, 20th Century; In Vitro Techniques; Male; Models, Theoretical; Pharmacokinetics; Phenoxybenzamine; Rabbits; Receptors, Drug; Serotonin; Serotonin Agents | 2010 |
Novel technique to determine the pK
Topics: Animals; Clonidine; Cystamine; Desipramine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Male; Mesenteric Arteries; Mice; Norepinephrine; Rats; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Synaptic Transmission; Yohimbine | 2017 |
Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach.
Topics: Cystamine; Enzyme Activation; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |