benextramine and cystamine

benextramine has been researched along with cystamine in 79 studies

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-199035 (44.30)18.7374
1990's33 (41.77)18.2507
2000's8 (10.13)29.6817
2010's3 (3.80)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boquet, I; Kraus, JL; Laras, Y; Moret, V; Norreel, JC; Rolland, A1
Hexum, TD; Li, W; MacDonald, RG2
Gürdal, H; Onaran, HO; Tulunay, FC1
McAuley, MA; Westfall, TC1
McFarland, JW; Newcomb, DM; Olson, JA; Rice, JR; Ricketts, AP1
Clark, JT1
Chu, SS; Doughty, MB; Hu, L; Li, K; Tessel, R1
Håkanson, R; Vaz, CA; Wahlestedt, C; Zukowska-Grojec, Z1
Dieudonne, MN; Giudicelli, Y; Pecquery, R1
Lafontan, M; Langin, D; Paris, H1
Black, JW; Shankley, NP1
Chu, SS; Doughty, MB; Li, K; Miller, DW; Tessel, RE1
Tabrizchi, R; Triggle, CR1
Koike, K; Maeda, O; Takayanagi, I1
Andersson, RG; Grundström, N; Karlsson, JO1
Berlan, M; Galitzky, J; Lafontan, M; Mauriege, P1
Chan, SL; Hurst, RD; Morgan, NG1
Hasselblatt, A; Schulz, A1
Insel, PA; McKernan, RM; Strickland, WR1
Purdy, RE; Weber, MA1
Furnace, G; Hamilton, CA; Reid, JL; Sumner, DJ1
Bond, RA; Charlton, KG; Clarke, DE2
Angeli, P; Brasili, L; Cassinelli, A; Melchiorre, C1
Nichols, AJ; Ruffolo, RR1
Murray, DL; Purdy, RE; Stupecky, GL1
Berlan, M; Lafontan, M; Taouis, M1
Hirst, GD; Lew, MJ1
Alvarez, M; Granados, R; Mauleón, D; Rosell, G; Salas, M; Sallés, J; Valls, N1
Galitzky, J; Paris, H; Taouis, M1
Furman, BL; Smith, M1
Brasili, L; Cristalli, G; Giardinà, D; Melchiorre, C; Picchio, MT; Quaglia, W1
de Jonge, A; Mathy, MJ; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B1
Angeli, P; Brancia, E; Brasili, L; Giardinà, D; Melchiorre, C; Quaglia, W1
Belleau, B; Benfey, BG; Brasili, L; Melchiorre, C2
Belleau, B; Benfey, BG; Benfey, TJ; Melchiorre, C1
Belleau, B; Benfey, BG; Melchiorre, C1
Belleau, B; Benfey, BG; Melchiorre, C; Montambault, M1
Atlas, D; Plotek, Y1
Coates, J; Weetman, DF1
Gallucci, P; Melchiorre, C1
Kirpekar, SM1
Angus, JA; Lew, MJ1
Angeli, P; Brancia, E; Brasili, L; Melchiorre, C1
Chaudhry, A; Vohra, MM1
Mottram, DR; Thakar, Y1
Amobi, NI; Smith, IC1
Corsi, M; Palea, S; Rimland, JM; Trist, DG1
Hasegawa, T; Maeda, Y; Nabeshima, T; Yamada, K1
Bolognesi, ML; Donatini, A; Ferri, S; Melchiorre, C; Romualdi, P1
Badia, A; Sallés, J1
Reis, DJ; Sun, MK1
Gastoł-Lewińska, L; Smiałowska, M; Tokarski, K1
Chaurasia, C; Doughty, MB; Misse, G; Tessel, R1
Elliott, SR; Pearce, WJ1
Arletti, R; Benelli, A; Bertolini, A; Menozzi, B; Poggioli, R1
Chaurasia, CS; Doughty, MB; Li, K1
Glavin, GB; Penner, SB; Smyth, DD1
Ernst, S; Lyte, M1
Dong, X; Doughty, MB; Miller, DW; Misse, GA; Tessel, RE1
Docherty, JR; Kearns, S; O'Rourke, M1
Corsi, M; Palea, S; Ratti, E; Rimland, JM; Trist, DG1
Saxena, PR; Stam, WB; Van der Graaf, PH1
Daniels, AJ; Harrington, WW; Hashim, MA; Leban, JJ; Matthews, J; Spaltenstein, A; Tadepalli, AS1
Martin, JR1
Beer, MS; Stanton, JA1
Horike, K; Houchi, H; Itoh, K; Katoh, I; Kitagawa, T; Tamaki, T; Yoshizumi, M1
Parker, MS; Parker, SL1
Heijnen, CJ; Kavelaars, A; Rouppe van der Voort, C; van de Pol, M1
Berggren, PO; Bokvist, K; Buschard, K; Gromada, J; Hansen, J; Høy, M; Juhl, K; Xiao-Gang, W1
Angeli, P; Bolognesi, ML; Buccioni, M; Marucci, G; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V1
Amobi, NI; Guillebaud, J; Kaisary, AV; Smith, IC; Turner, E1
Bailey, SR; Berhane, Y; Elliott, J1
Bodenstein, J; Brink, CB; Venter, DP1
Black, JW; Leff, P; Shankley, NP; Wood, J1
Angus, JA; Rajasekaran, P; Wright, CE1
Cozza, G; Di Paolo, ML; Milelli, A; Minarini, A; Minniti, E; Rosini, M; Sarno, S; Ursini, F; Zonta, F1

Reviews

1 review(s) available for benextramine and cystamine

ArticleYear
Support for a role for feedback regulation of norepinephrine release.
    Federation proceedings, 1984, Volume: 43, Issue:5

    Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Cocaine; Cystamine; Diethylamines; Drug Synergism; Electric Stimulation; Ephedrine; Feedback; Naphthalenes; Norepinephrine; Phenoxybenzamine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Synaptic Membranes

1984

Other Studies

78 other study(ies) available for benextramine and cystamine

ArticleYear
Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.
    Bioorganic & medicinal chemistry letters, 2008, Jan-01, Volume: 18, Issue:1

    Topics: Animals; Aza Compounds; Cell Movement; Disulfides; Drug Design; Lateral Ventricles; Macrocyclic Compounds; Mice; Neurons; Peptides, Cyclic; Polyamines

2008
Role of sulfhydryl groups in Y2 neuropeptide Y receptor binding activity.
    The Journal of biological chemistry, 1992, Apr-15, Volume: 267, Issue:11

    Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Cattle; Cystamine; Electrophoresis, Polyacrylamide Gel; Hippocampus; In Vitro Techniques; Membranes; Neuropeptide Y; Receptors, Neuropeptide Y; Receptors, Neurotransmitter; Sulfhydryl Compounds

1992
Role of alpha-adrenoceptors in the effects of buspirone and 5-carboxamidotryptamine in rabbit isolated thoracic aorta.
    General pharmacology, 1992, Volume: 23, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Buspirone; Cystamine; Dose-Response Relationship, Drug; Drug Interactions; Ketanserin; Methysergide; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Vasoconstriction

1992
Possible location and function of neuropeptide Y receptor subtypes in the rat mesenteric arterial bed.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Drug Interactions; Male; Mesenteric Arteries; Neuropeptide Y; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Neuropeptide Y; Receptors, Neurotransmitter

1992
Further investigation of anticoccidial activity of 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Biotransformation; Cells, Cultured; Chickens; Coccidiosis; Coccidiostats; Cystamine; Eimeria tenella; Imidazoles; Indazoles; Intestines; Ligands; Poultry Diseases; Yohimbine

1992
Benextramine, a putative neuropeptide Y receptor antagonist, attenuates the termination of receptivity.
    Physiology & behavior, 1992, Volume: 52, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Estradiol; Female; Male; Ovariectomy; Posture; Progesterone; Rats; Receptors, Neuropeptide Y; Sexual Behavior, Animal

1992
Benextramine-neuropeptide Y (NPY) binding site interactions: characterization of 3H-NPY binding site heterogeneity in rat brain.
    Neuropeptides, 1992, Volume: 23, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cystamine; Male; Membranes; Molecular Sequence Data; Neuropeptide Y; Peptide YY; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Sensitivity and Specificity; Tritium

1992
Benextramine irreversibly inhibits [125I]neuropeptide Y affinity labeling of the Y2 binding protein in bovine hippocampus.
    European journal of pharmacology, 1991, May-25, Volume: 207, Issue:1

    Topics: Affinity Labels; Animals; Carrier Proteins; Cattle; Cross-Linking Reagents; Cystamine; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Membranes; Neuropeptide Y; Succinimides

1991
Norepinephrine and neuropeptide Y: vasoconstrictor cooperation in vivo and in vitro.
    The American journal of physiology, 1990, Volume: 258, Issue:3 Pt 2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Consciousness; Cystamine; Drug Synergism; Inositol Phosphates; Male; Neuropeptide Y; Norepinephrine; Prazosin; Pulmonary Artery; Radioligand Assay; Rats; Rats, Inbred Strains; Vasoconstrictor Agents

1990
Evidence against the "spare" receptor nature of alpha 2-adrenoceptors in hamster white fat cells.
    Biochemistry international, 1990, Volume: 20, Issue:4

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Cell Membrane; Cricetinae; Cyclic AMP; Cystamine; Kinetics; Male; Mesocricetus; Quinoxalines; Receptors, Adrenergic, alpha

1990
Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites.
    Molecular pharmacology, 1990, Volume: 37, Issue:6

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Binding Sites; Brimonidine Tartrate; Cell Membrane; Cystamine; Dioxanes; Dioxins; Epinephrine; Female; Humans; Idazoxan; Magnesium Chloride; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Tritium; Yohimbine

1990
Interpretation of agonist affinity estimations: the question of distributed receptor states.
    Proceedings of the Royal Society of London. Series B, Biological sciences, 1990, Jun-22, Volume: 240, Issue:1299

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Cystamine; Kinetics; Mathematics; Models, Biological; Muscle, Smooth, Vascular; Pargyline; Phenoxybenzamine; Potassium Chloride; Rabbits; Receptors, Cell Surface; Serotonin

1990
Benextramine: a long-lasting neuropeptide Y receptor antagonist.
    European journal of pharmacology, 1990, Aug-21, Volume: 185, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cystamine; Membranes; Rats; Rats, Inbred Strains; Receptors, Neuropeptide Y; Receptors, Neurotransmitter

1990
Benextramine and nifedipine distinguish between sub-classes of alpha 1-adrenoceptors.
    Life sciences, 1989, Volume: 45, Issue:26

    Topics: Animals; Blood Pressure; Body Temperature; Cystamine; Decerebrate State; Diastole; Male; Methoxamine; Nifedipine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha

1989
Effect of aging on presynaptic alpha 2-adrenoceptor mechanisms in guinea pig ileum.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1989, Volume: 92, Issue:2

    Topics: Aging; Animals; Clonidine; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Norepinephrine; Receptors, Adrenergic, alpha; Synapses

1989
Characterization of pigment aggregating alpha 2-adrenoceptors of fish melanophores by use of different agonists after partial irreversible receptor inactivation.
    British journal of pharmacology, 1989, Volume: 97, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cystamine; Fishes; In Vitro Techniques; Melanophores; Pigments, Biological; Receptors, Adrenergic, alpha

1989
Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2

    Topics: Adenosine Deaminase; Adenylyl Cyclase Inhibitors; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Brimonidine Tartrate; Cystamine; Female; Guanosine Triphosphate; Humans; Lipolysis; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine

1989
Effects of benextramine on the adrenergic inhibition of insulin secretion in isolated rat pancreatic islets.
    Journal of molecular endocrinology, 1989, Volume: 2, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Carbachol; Cell Separation; Clonidine; Cystamine; Epinephrine; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors

1989
Dual action of clonidine on insulin release: suppression, but stimulation when alpha 2-adrenoceptors are blocked.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Mice

1989
Selective blockade and recovery of cell surface alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. Studies with the irreversible antagonist benextramine.
    Molecular pharmacology, 1988, Volume: 33, Issue:1

    Topics: Binding, Competitive; Cell Compartmentation; Cell Membrane; Cyclic AMP; Cystamine; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Receptors, Adrenergic, alpha; Tumor Cells, Cultured; Yohimbine

1988
Angiotensin II amplification of alpha-adrenergic vasoconstriction: role of receptor reserve.
    Circulation research, 1988, Volume: 63, Issue:4

    Topics: Angiotensin II; Animals; Cystamine; Dose-Response Relationship, Drug; Drug Interactions; Femoral Artery; Male; Nifedipine; Norepinephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine

1988
Recovery of alpha-adrenoreceptor mediated responses and binding site number after intravenous benextramine in the rabbit.
    Journal of autonomic pharmacology, 1985, Volume: 5, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Brain; Clonidine; Cystamine; Injections, Intravenous; Male; Membranes; Phenoxybenzamine; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Spleen; Time Factors

1985
Responses to norepinephrine resistant to inhibition by alpha and beta adrenoceptor antagonists.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Nordefrin; Norepinephrine; Receptors, Adrenergic; Reserpine; Yohimbine

1986
Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum.
    Life sciences, 1986, May-05, Volume: 38, Issue:18

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta

1986
The relationship between alterations in alpha 1-adrenoceptor reserve by phenoxybenzamine and benextramine and the sensitivity of cirazoline-induced pressor responses to inhibition by nifedipine.
    European journal of pharmacology, 1986, Jul-31, Volume: 126, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cystamine; Denervation; Imidazoles; Male; Nifedipine; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha

1986
Receptors for 5-hydroxytryptamine in rabbit blood vessels: activation of alpha adrenoceptors in rabbit thoracic aorta.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Animals; Aorta, Thoracic; Cystamine; Dose-Response Relationship, Drug; Lysergic Acid Diethylamide; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reserpine; Serotonin; Vasoconstriction; Vasomotor System

1987
Alpha 2-adrenergic receptor turnover in adipose tissue and kidney: irreversible blockade of alpha 2-adrenergic receptors by benextramine.
    Molecular pharmacology, 1987, Volume: 31, Issue:1

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Clonidine; Cricetinae; Cystamine; Dose-Response Relationship, Drug; Kidney; Lipid Mobilization; Male; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine

1987
Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cystamine; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Quinoxalines; Receptors, Adrenergic

1986
Lack of involvement of alpha-adrenoceptors in sympathetic neural vasoconstriction in the hindquarters of the rabbit.
    British journal of pharmacology, 1987, Volume: 90, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Electric Stimulation; Female; Gagging; Hindlimb; Male; Norepinephrine; Phenoxybenzamine; Phentolamine; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction

1987
Structure-activity relationships among di- and tetramine disulfides related to benextramine.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:7

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Disulfides; Male; Norepinephrine; Rats; Stereoisomerism; Structure-Activity Relationship

1987
In vitro study of alpha 2-adrenoceptor turnover and metabolism using the adenocarcinoma cell line HT29.
    Molecular pharmacology, 1987, Volume: 32, Issue:5

    Topics: Adenocarcinoma; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Cell Line; Cell Membrane; Colonic Neoplasms; Cyclic AMP; Cystamine; Kinetics; Phenoxybenzamine; Prazosin; Receptors, Adrenergic, alpha; Yohimbine

1987
Augmentation of glucose induced insulin secretion by pertussis vaccine, phentolamine and benextramine: involvement of mechanisms additional to prevention of the inhibitory actions of catecholamines in rats.
    Acta endocrinologica, 1988, Volume: 118, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Catecholamines; Clonidine; Cystamine; Epinephrine; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pertussis Toxin; Pertussis Vaccine; Phentolamine; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella

1988
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:9

    Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Cystamine; Epinephrine; Humans; Male; Muscle Contraction; Platelet Aggregation Inhibitors; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vas Deferens

1988
Effects of the irreversible alpha-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in pithed rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 329, Issue:4

    Topics: Animals; Azepines; Clonidine; Cystamine; Decerebrate State; Diastole; Dose-Response Relationship, Drug; Imidazoles; Male; Nifedipine; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoconstriction

1985
Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Animals; Atrial Function; Biological Assay; Carbachol; Chemical Phenomena; Chemistry; Cystamine; Disulfides; Guinea Pigs; Histamine; Ileum; Isoproterenol; Jejunum; Male; Muscle Contraction; Polyamines; Rats; Receptors, Adrenergic, alpha; Serotonin; Structure-Activity Relationship; Trachea; Vas Deferens

1985
Potentiation and inhibition of nicotinic effects on striated muscle by the tetramine disulfide benextramine.
    Canadian journal of physiology and pharmacology, 1980, Volume: 58, Issue:8

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Anura; Carbachol; Cystamine; Drug Synergism; In Vitro Techniques; Muscle Contraction; Physostigmine; Receptors, Cholinergic; Receptors, Nicotinic

1980
Inhibition by the tetramine disulphide, benextramine, of cardiac chronotropic histamine H2-receptor-mediated effects.
    British journal of pharmacology, 1982, Volume: 75, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Cimetidine; Cystamine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Time Factors

1982
Presynaptic effect of clonidine antagonized by the tetramine disulphide, benextramine.
    British journal of pharmacology, 1982, Volume: 75, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Clonidine; Cocaine; Cystamine; Female; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Neurons; Phentolamine; Synapses

1982
Inhibition of adrenaline-induced platelet aggregation by the alpha-adrenoceptor blocking drug benextramine.
    British journal of pharmacology, 1982, Volume: 76, Issue:2

    Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Collagen; Cystamine; Epinephrine; Humans; Phentolamine; Platelet Aggregation; Quinidine; Verapamil

1982
Characterization of benextramine as an irreversible alpha-adrenergic blocker and as a blocker of potassium-activated calcium channels.
    European journal of biochemistry, 1983, Jul-01, Volume: 133, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Calcium Channel Blockers; Cystamine; In Vitro Techniques; Potassium; Rats; Synaptosomes

1983
Demonstration of alpha 1s-adrenoceptors after exposure of the rat anococcygeus to benextramine.
    British journal of pharmacology, 1983, Volume: 80, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; In Vitro Techniques; Male; Muscle Contraction; Muscles; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha

1983
The irreversible alpha-blocker benextramine interacts with two different thiol groups.
    Il Farmaco; edizione scientifica, 1983, Volume: 38, Issue:12

    Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Calcium; Cystamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Sulfhydryl Compounds; Vas Deferens

1983
Reversible inhibition of neuronal uptake by benextramine, an irreversible presynaptic alpha-adrenoceptor antagonist.
    European journal of pharmacology, 1984, Feb-10, Volume: 98, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Biogenic Amines; Cystamine; Desipramine; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Neurons; Norepinephrine; Phenoxybenzamine; Rabbits; Species Specificity; Sympathetic Nervous System

1984
N,N''-(dithio-2,1-ethanediyl)bis[N'-(pyrrol-2-ylmethyl)-1, 6,- hexanediamine] (pyrextramine), a new irreversible alpha 1-adrenoreceptor blocking agent of the tetramine disulfide class.
    European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Vas Deferens

1984
Antagonism by the tetramine disulfide benextramine of the inhibitory effects mediated by prejunctional alpha 2-adrenoceptors and by postjunctional histamine H2 receptors in the mouse vas deferens.
    Canadian journal of physiology and pharmacology, 1984, Volume: 62, Issue:9

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; Dose-Response Relationship, Drug; Histamine; In Vitro Techniques; Male; Mice; Receptors, Adrenergic, alpha; Receptors, Histamine; Receptors, Histamine H2; Vas Deferens

1984
The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:10

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nordefrin; Phenethylamines; Receptors, Adrenergic, alpha

1984
Reactivation by cysteamine of vascular alpha adrenoceptors blocked by the tetramine disulfide benextramine and interaction of benextramine with phenoxybenzamine.
    Canadian journal of physiology and pharmacology, 1980, Volume: 58, Issue:12

    Topics: Animals; Aorta; Cystamine; Cysteamine; Dose-Response Relationship, Drug; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha

1980
Differential inhibition in the human vas deferens by phenoxybenzamine: a possible mechanism for its contraceptive action.
    Journal of reproduction and fertility, 1995, Volume: 103, Issue:2

    Topics: Adrenergic alpha-Antagonists; Calcium; Clonidine; Contraceptive Agents, Male; Cystamine; Humans; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Prazosin; Vas Deferens

1995
Discrimination by benextramine between the NPY-Y1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein.
    British journal of pharmacology, 1995, Volume: 115, Issue:1

    Topics: Animals; Culture Techniques; Cystamine; Humans; Male; Neuropeptide Y; Peptides; Rabbits; Receptors, Neuropeptide Y; Saphenous Vein; Vas Deferens

1995
Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-D-aspartate-induced aversive behavior.
    European journal of pharmacology, 1995, Mar-06, Volume: 275, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Calcitonin; Cystamine; GABA Antagonists; Injections, Spinal; Male; Mice; Morphine; N-Methylaspartate; Naloxone; Phentolamine; Pindolol; Piperazines; Propranolol; Receptors, Neurotransmitter; Ritanserin; Serotonin Antagonists; Tropanes

1995
Binding profile of benextramine at neuropeptide Y receptor subtypes in rat brain areas.
    European journal of pharmacology, 1994, Nov-14, Volume: 265, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Brain Stem; Computer Simulation; Cystamine; Diamines; Frontal Lobe; Hippocampus; Male; Parietal Lobe; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y

1994
Selective enrichment with alpha 1A- and alpha 1B-adrenoceptor subtypes in rat brain cortical membranes.
    European journal of pharmacology, 1994, Feb-15, Volume: 266, Issue:3

    Topics: Adrenergic alpha-Antagonists; Alkylating Agents; Alkylation; Animals; Binding Sites; Cerebral Cortex; Clonidine; Cystamine; Dihydropyridines; Dioxanes; Phenoxybenzamine; Phentolamine; Prazosin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha

1994
Intrathecal kynurenate but not benextramine blocks hypoxic sympathoexcitation in chemodenervated anesthetized rats.
    Journal of the autonomic nervous system, 1994, Volume: 47, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Cystamine; Hypoxia; Injections, Spinal; Kynurenic Acid; Male; Medulla Oblongata; Muscimol; Rats; Rats, Sprague-Dawley; Spinal Cord; Stereotaxic Techniques; Sympathectomy, Chemical; Sympathetic Nervous System

1994
The role of alpha-1 adrenergic receptors in the stimulating effect of neuropeptide Y (NPY) on rat behavioural activity.
    Neuropeptides, 1994, Volume: 26, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Cystamine; Frontal Lobe; Male; Motor Activity; Neuropeptide Y; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha

1994
Nonpeptide peptidomimetic antagonists of the neuropeptide Y receptor: benextramine analogs with selectivity for the peripheral Y2 receptor.
    Journal of medicinal chemistry, 1994, Jul-08, Volume: 37, Issue:14

    Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cystamine; Male; Molecular Sequence Data; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Structure-Activity Relationship

1994
Effects of maturation on alpha-adrenergic receptor affinity and occupancy in small cerebral arteries.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Cerebral Arteries; Cystamine; Dose-Response Relationship, Drug; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Sheep; Vasoconstriction; Yohimbine

1994
Benextramine, an NPY antagonist, improves sexual behavior in male rats.
    Neuropeptides, 1994, Volume: 26, Issue:5

    Topics: Animals; Cystamine; Female; Male; Neuropeptide Y; Rats; Rats, Wistar; Sexual Behavior, Animal

1994
Benextramine-neuropeptide Y receptor interactions: contribution of the benzylic moieties to [3H]neuropeptide Y displacement activity.
    Journal of medicinal chemistry, 1993, Jan-22, Volume: 36, Issue:2

    Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Binding Sites; Brain; Cystamine; Drug Interactions; Male; Molecular Sequence Data; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Structure-Activity Relationship

1993
Effects of neuropeptide Y and [Leu31,Pro34] neuropeptide Y on experimental gastric lesion formation and gastric secretion in the rat.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Gastric Acid; Gastric Mucosa; Immobilization; Ligation; Male; Neuropeptide Y; Pepsin A; Pylorus; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Stomach; Stomach Ulcer; Stress, Physiological

1993
Alpha and beta adrenergic receptor involvement in catecholamine-induced growth of gram-negative bacteria.
    Biochemical and biophysical research communications, 1993, Jan-29, Volume: 190, Issue:2

    Topics: Alprenolol; Catecholamines; Cystamine; Escherichia coli; Isoproterenol; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stereoisomerism; Yersinia enterocolitica

1993
Characterization of vascular postsynaptic neuropeptide Y receptor function and regulation. 1. NPY-induced constriction in isolated rat femoral artery rings is mediated by both Y1 and Y2 receptors: evidence from benextramine protection studies.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: Animals; Cystamine; Drug Antagonism; Femoral Artery; In Vitro Techniques; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Synapses; Vasoconstriction

1993
Investigation of the actions of chloroethylclonidine in rat aorta.
    British journal of pharmacology, 1995, Volume: 115, Issue:8

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxathiins; Phenoxybenzamine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spiperone; Xylazine; Yohimbine

1995
Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.
    British journal of pharmacology, 1995, Volume: 116, Issue:5

    Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuropeptide Y; Peptide Fragments; Prostate; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Suramin; Vas Deferens

1995
Benextramine acts as an irreversible noncompetitive antagonist of U46619-mediated contraction of the rat small mesenteric artery.
    European journal of pharmacology, 1996, Apr-11, Volume: 300, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Animals; Cystamine; Male; Mesenteric Arteries; Muscle Contraction; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents

1996
Hemodynamic characterization of a novel neuropeptide Y receptor antagonist.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:5

    Topics: Anesthesia; Animals; Cystamine; Dogs; Hemodynamics; Hypertension; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Neuropeptide Y

1996
Pressor effect of the putative M1 muscarinic receptor agonist MCN-A-343 in the conscious rat.
    Life sciences, 1996, Volume: 59, Issue:22

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Adrenal Medulla; Adrenergic Agonists; Adrenergic Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cystamine; Drug Interactions; Guanethidine; Male; Muscarinic Agonists; Neuropeptide Y; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Yohimbine

1996
Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding.
    European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Cell Line; Clone Cells; Cystamine; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium

1997
Neuropeptide Y as a stimulator of Na+ -dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Calcium; Cells, Cultured; Cystamine; Heart; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Sodium

1997
Ligand association with the rabbit kidney and brain Y1, Y2 and Y5-like neuropeptide Y (NPY) receptors shows large subtype-related differences in sensitivity to chaotropic and alkylating agents.
    Regulatory peptides, 2000, Feb-08, Volume: 87, Issue:1-3

    Topics: Alkylating Agents; Amiloride; Amino Acid Sequence; Animals; Brain; CHO Cells; Clonidine; Cricetinae; Cystamine; Ethylmaleimide; Gastrointestinal Hormones; GTP-Binding Protein alpha Subunits, Gs; Guinea Pigs; Humans; Hypothalamus; Kidney; Ligands; Mesylates; Molecular Sequence Data; Peptide Fragments; Peptide YY; Rabbits; Radioligand Assay; Receptors, Neuropeptide Y; Sodium Cholate; Sulfhydryl Compounds; Urea

2000
Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors.
    Journal of neuroimmunology, 2000, Aug-01, Volume: 108, Issue:1-2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Cells, Cultured; Cystamine; Dexamethasone; Enzyme Activation; Humans; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Monocytes; Norepinephrine; Phosphorylation; Phytohemagglutinins; Receptors, Adrenergic, alpha-1; RNA, Messenger; Transcriptional Activation; Yohimbine

2000
Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells.
    The Journal of biological chemistry, 2001, Jan-12, Volume: 276, Issue:2

    Topics: Adenylate Cyclase Toxin; Animals; Calcineurin; Cells, Cultured; Clorgyline; Cyclosporine; Cystamine; Diazoxide; Exocytosis; Glucagon; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Indoles; Islets of Langerhans; Male; Membrane Potentials; Nitriles; Oligodeoxyribonucleotides, Antisense; Pertussis Toxin; Phentolamine; Potassium Channels; Proto-Oncogene Proteins; Pyrethrins; Rats; Rats, Inbred Lew; Virulence Factors, Bordetella

2001
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.
    Journal of medicinal chemistry, 2001, Feb-01, Volume: 44, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Cystamine; Disulfides; In Vitro Techniques; Male; Polyamines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Structure-Activity Relationship; Vas Deferens

2001
Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens.
    British journal of pharmacology, 2002, Volume: 136, Issue:1

    Topics: Adrenergic alpha-Antagonists; Cystamine; Dibenzylchlorethamine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha-1; Vas Deferens; Vasoconstrictor Agents

2002
Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.
    American journal of veterinary research, 2003, Volume: 64, Issue:9

    Topics: Adrenergic alpha-Agonists; Animals; Biogenic Amines; Blood Platelets; Cecum; Cystamine; Femoral Artery; Femoral Vein; Fluoxetine; Horses; In Vitro Techniques; Isometric Contraction; Ketanserin; Male; Muscle, Smooth, Vascular; Platelet Activation; Serotonin Antagonists; Vasoconstriction

2003
Phenoxybenzamine and benextramine, but not 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride, display irreversible noncompetitive antagonism at G protein-coupled receptors.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cyclic AMP; Cystamine; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Humans; Inositol Phosphates; Ligands; Phenoxybenzamine; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Second Messenger Systems; Serotonin Receptor Agonists; Signal Transduction

2005
An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. 1985.
    British journal of pharmacology, 2010, Volume: 160 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Cystamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; History, 20th Century; In Vitro Techniques; Male; Models, Theoretical; Pharmacokinetics; Phenoxybenzamine; Rabbits; Receptors, Drug; Serotonin; Serotonin Agents

2010
Novel technique to determine the pK
    European journal of pharmacology, 2017, Apr-05, Volume: 800

    Topics: Animals; Clonidine; Cystamine; Desipramine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Male; Mesenteric Arteries; Mice; Norepinephrine; Rats; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Synaptic Transmission; Yohimbine

2017
Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach.
    The FEBS journal, 2019, Volume: 286, Issue:24

    Topics: Cystamine; Enzyme Activation; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2019