bendazac-lysine has been researched along with bendazac* in 2 studies
2 other study(ies) available for bendazac-lysine and bendazac
Article | Year |
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Bendazac decreases in vitro glycation of human lens crystallins. Decrease of in vitro protein glycation by bendazac.
Bendazac has been used as an anti-cataractogenic drug. It has been reported that this acts by preventing protein denaturation. In this study the ability of bendazac to inhibit in vitro glycation of human lens crystallins was evaluated. Possible effects of bendazac were detected by incubation of WS crystallins with the reducing sugars glucose and fructose. The efficiency of bendazac was evaluated by means of selected parameters including: browning, glycation (measured as tyrosine content) and specific NTP-fluorescence. The results showed clearly that bendazac (bendazac L-lysine and sodium) inhibits the early stages of protein glycation, as well as the formation of fluorescent advanced glycation products. Bendazac lysine (20 mM) proved to be more effective in inhibiting fluorescence development (67% inhibition) that the corresponding sodium salt (35% inhibition). No significant differences were found with respect to furosine levels; about 40% inhibition was produced with either bendazac lysine or sodium salt bendazac clearly inhibits glycation of human lens crystallins, as can be efficiently monitored by following specific changes in lens protein fluorescence. These results may constitute a new and relevant therapeutic approach to monitoring cataract development. Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Crystallins; Dose-Response Relationship, Drug; Fluorescence; Fructose; Glucose; Glycation End Products, Advanced; Glycosylation; Humans; Indazoles; Lens, Crystalline | 1995 |
A comparative study of the oral absorption in man of bendazac and its lysine salt.
Topics: Absorption; Administration, Oral; Adult; Anti-Inflammatory Agents; Female; Humans; Indazoles; Male; Pyrazoles; Tablets; Time Factors | 1982 |